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Conserved domains on  [gi|30180057|emb|CAD84057|]
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TPR repeat [Nitrosomonas europaea ATCC 19718]

Protein Classification

type IV pilus biogenesis/stability protein PilF/PilW( domain architecture ID 11494436)

type IV pilus biogenesis/stability protein PilF/PilW is an outer membrane lipoprotein that is required for multimerization and localization of type IV pilus secretin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 8-246 6.83e-106

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


:

Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 306.57  E-value: 6.83e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057     8 GVLGFLVWLAGCGHAPvqekPTPEELKQRALQS-AKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYM 86
Cdd:TIGR02521   1 LALVFLLALTGCVTTP----DVPRSSRTTDRNKaAKIRVQLALGYLEQGDLEVAKENLDKALEHDPDDYLAYLALALYYQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057    87 DLQEDDRAEWNFERGLGITPNDPDIRNNFGWFLCQRKPdgIEQAIGHFMAAVRDPLYETPERTYTNAGLCVLKQNDFERA 166
Cdd:TIGR02521  77 QLGELEKAEDSFRRALTLNPNNGDVLNNYGTFLCQQGK--YEQAMQQFEQAIEDPLYPQPARSLENAGLCALKAGDFDKA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   167 QSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQKRFP 246
Cdd:TIGR02521 155 EKYLTRALQIDPQRPESLLELAELYYLRGQYKDARAYLERYQQTYNQTAESLWLGIRIARALGDVAAAQRYGAQLQKLFP 234
 
Name Accession Description Interval E-value
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 8-246 6.83e-106

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 306.57  E-value: 6.83e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057     8 GVLGFLVWLAGCGHAPvqekPTPEELKQRALQS-AKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYM 86
Cdd:TIGR02521   1 LALVFLLALTGCVTTP----DVPRSSRTTDRNKaAKIRVQLALGYLEQGDLEVAKENLDKALEHDPDDYLAYLALALYYQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057    87 DLQEDDRAEWNFERGLGITPNDPDIRNNFGWFLCQRKPdgIEQAIGHFMAAVRDPLYETPERTYTNAGLCVLKQNDFERA 166
Cdd:TIGR02521  77 QLGELEKAEDSFRRALTLNPNNGDVLNNYGTFLCQQGK--YEQAMQQFEQAIEDPLYPQPARSLENAGLCALKAGDFDKA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   167 QSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQKRFP 246
Cdd:TIGR02521 155 EKYLTRALQIDPQRPESLLELAELYYLRGQYKDARAYLERYQQTYNQTAESLWLGIRIARALGDVAAAQRYGAQLQKLFP 234
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
41-244 4.83e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 80.82  E-value: 4.83e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  41 AKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGWFLC 120
Cdd:COG0457   8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQ 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 121 QRKpdGIEQAIGHFMAAVR-DPLYetpERTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKK 199
Cdd:COG0457  88 ALG--RYEEALEDYDKALElDPDD---AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEE 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 30180057 200 AWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQKR 244
Cdd:COG0457 163 ALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQAL 207
TPR_19 pfam14559
Tetratricopeptide repeat;
160-215 2.05e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 38.72  E-value: 2.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 30180057   160 QNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYPPAP 215
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDP 56
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 158-227 3.35e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 41.99  E-value: 3.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30180057   158 LKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRylqtyPPAPG--SLWLAVRIARA 227
Cdd:PRK11447  614 QQRGDYAAARAAYQRVLTREPGNADARLGLIEVDIAQGDLAAARAQLAK-----LPATAndSLNTQRRVALA 680
Menin cd14456
Scaffolding protein menin encoded by the MEN1 gene; MEN1 is the gene responsible for multiple ...
 20-62 8.45e-03

Scaffolding protein menin encoded by the MEN1 gene; MEN1 is the gene responsible for multiple endocrine neoplasia type 1, and it has been characterized as a tumor suppressor gene that encodes a protein called menin. Menin is mostly found in the nucleus and can regulate gene expression in a positive and in a negative way, and it has been shown to interact with transcription activators, transcription repressors, cell signaling proteins, and various other proteins. It plays major roles in DNA repair, the regulation of the cell cycle, and chromatin remodeling.


Pssm-ID: 271218  Cd Length: 437  Bit Score: 37.23  E-value: 8.45e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 30180057  20 GHAPVQEKPTPEELKQRALQSAKIH---------TELAGQYYHRGQYRVAIE 62
Cdd:cd14456 279 EISPTPGRPPCLKLFNEAISSARKYyrnhhvypyTYLGGYYYRHGKYREALR 330
 
Name Accession Description Interval E-value
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 8-246 6.83e-106

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 306.57  E-value: 6.83e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057     8 GVLGFLVWLAGCGHAPvqekPTPEELKQRALQS-AKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYM 86
Cdd:TIGR02521   1 LALVFLLALTGCVTTP----DVPRSSRTTDRNKaAKIRVQLALGYLEQGDLEVAKENLDKALEHDPDDYLAYLALALYYQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057    87 DLQEDDRAEWNFERGLGITPNDPDIRNNFGWFLCQRKPdgIEQAIGHFMAAVRDPLYETPERTYTNAGLCVLKQNDFERA 166
Cdd:TIGR02521  77 QLGELEKAEDSFRRALTLNPNNGDVLNNYGTFLCQQGK--YEQAMQQFEQAIEDPLYPQPARSLENAGLCALKAGDFDKA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   167 QSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQKRFP 246
Cdd:TIGR02521 155 EKYLTRALQIDPQRPESLLELAELYYLRGQYKDARAYLERYQQTYNQTAESLWLGIRIARALGDVAAAQRYGAQLQKLFP 234
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
41-244 4.83e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 80.82  E-value: 4.83e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  41 AKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGWFLC 120
Cdd:COG0457   8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQ 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 121 QRKpdGIEQAIGHFMAAVR-DPLYetpERTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKK 199
Cdd:COG0457  88 ALG--RYEEALEDYDKALElDPDD---AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEE 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 30180057 200 AWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQKR 244
Cdd:COG0457 163 ALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQAL 207
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 39-250 6.40e-18

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 80.93  E-value: 6.40e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  39 QSAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGwF 118
Cdd:COG2956  40 ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLA-E 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 119 LCQRKPDGiEQAIGHFMAAVRdpLYETPERTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVK 198
Cdd:COG2956 119 IYEQEGDW-EKAIEVLERLLK--LGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYE 195

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 30180057 199 KAWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQKRFPDSRE 250
Cdd:COG2956 196 EAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL 247
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 31-244 2.77e-17

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 79.00  E-value: 2.77e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  31 EELKQRALQSAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPD 110
Cdd:COG2956  66 QKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 111 IRNNFGwfLCQRKPDGIEQAIGHFMAAVRdpLYETPERTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVEL 190
Cdd:COG2956 146 AYCELA--ELYLEQGDYDEAIEALEKALK--LDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAEL 221

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 30180057 191 DFSRGEVKKAWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQKR 244
Cdd:COG2956 222 YEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
35-244 1.82e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.81  E-value: 1.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  35 QRALQ----SAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPD 110
Cdd:COG0457  32 EKALEldpdDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAE 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 111 IRNNFGWFLCQRKpdGIEQAIGHFMAAVRdpLYETPERTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVEL 190
Cdd:COG0457 112 ALYNLGLALLELG--RYDEAIEAYERALE--LDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAA 187

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 30180057 191 DFSRGEVKKAWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQKR 244
Cdd:COG0457 188 LALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALY 241
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 31-263 3.35e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 71.95  E-value: 3.35e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  31 EELKQRALQSAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPD 110
Cdd:COG3914  68 AAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAE 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 111 IRNNFGwfLCQRKPDGIEQAIGHFMAAVR-DPlyETPErTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVE 189
Cdd:COG3914 148 AYLNLG--EALRRLGRLEEAIAALRRALElDP--DNAE-ALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLF 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 190 LDFSRG--EVKKAWAAINRYLQTYPPAPGSLWLAvriarANGDVNAETNYAFQLQ--KRFPDS--REARESRAGRLNHER 263
Cdd:COG3914 223 ALRQACdwEVYDRFEELLAALARGPSELSPFALL-----YLPDDDPAELLALARAwaQLVAAAaaPELPPPPNPRDPDRK 297
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 4-261 7.33e-13

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 68.19  E-value: 7.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057     4 LIRTGVLGFLVWLAGCGhapvqeKPTPEELkqraLQSAKihtelagQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGL 83
Cdd:TIGR02917   2 IKITALLCIALALSACG------DQSPEEL----IEAAK-------SYLQKNKYKAAIIQLKNALQKDPNDAEARFLLGK 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057    84 VYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGW-FLCQRKPDgieQAIGHFMAAVRDPLYETPErTYTNAGLCVLKQND 162
Cdd:TIGR02917  65 IYLALGDYAAAEKELRKALSLGYPKNQVLPLLARaYLLQGKFQ---QVLDELPGKTLLDDEGAAE-LLALRGLAYLGLGQ 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   163 FERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYPPAPGSLWLAVRIARANGD---VNAETNYAF 239
Cdd:TIGR02917 141 LELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNielALAAYRKAI 220

                         250       260
                  ....*....|....*....|..
gi 30180057   240 QLQKRFPDSREARESRAGRLNH 261
Cdd:TIGR02917 221 ALRPNNIAVLLALATILIEAGE 242
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
68-212 1.95e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.03  E-value: 1.95e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  68 LQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGWFLCQRKpdGIEQAIGHFMAAVR-DPLYetp 146
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLG--RYEEALADYEQALElDPDD--- 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30180057 147 ERTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYP 212
Cdd:COG0457  76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDP 141
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 46-256 2.31e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.14  E-value: 2.31e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  46 ELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGW-FLCQRKP 124
Cdd:COG2956  13 FKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQdYLKAGLL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 125 DgieQAIGHFMAAVRDPLYEtpERTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAI 204
Cdd:COG2956  93 D---RAEELLEKLLELDPDD--AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEAL 167

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 30180057 205 NRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQKRFPDSREARESRA 256
Cdd:COG2956 168 EKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLA 219
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 39-212 1.13e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.98  E-value: 1.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  39 QSAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGWF 118
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 119 LcqrkpdgieqaighfmaavrdplyetpertytnaglcvLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVK 198
Cdd:COG4783  82 L--------------------------------------LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPD 123

                       170
                ....*....|....
gi 30180057 199 KAWAAINRYLQTYP 212
Cdd:COG4783 124 EAIAALEKALELDP 137
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 60-227 1.00e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 58.09  E-value: 1.00e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  60 AIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGWFLcqrkpdgieqaighfmaavr 139
Cdd:COG4235   2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEAL-------------------- 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 140 dplyetpertytnaglcvLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYPPAPGSLW 219
Cdd:COG4235  62 ------------------LAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARL 123


                ....*...
gi 30180057 220 LAVRIARA 227
Cdd:COG4235 124 LEASIAEA 131
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
84-178 7.90e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.71  E-value: 7.90e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  84 VYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGWFLCQRKpdGIEQAIGHFMAAVRDPLYetpERTYTNAGLCVLKQNDF 163
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQG--RYDEAIALEKALKLDPNN---AEALLNLAELLLELGDY 75

                        90
                ....*....|....*
gi 30180057 164 ERAQSYFQEALVIRP 178
Cdd:COG3063  76 DEALAYLERALELDP 90
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 28-203 9.93e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 55.47  E-value: 9.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057    28 PTPEELKQRALQSAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPN 107
Cdd:TIGR02917 248 KHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPN 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   108 DPDIRnnfgwflcqRKPDGIEQAIGHFMAAVR--DPLYETPER---TYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPL 182
Cdd:TIGR02917 328 SHQAR---------RLLASIQLRLGRVDEAIAtlSPALGLDPDdpaALSLLGEAYLALGDFEKAAEYLAKATELDPENAA 398

                         170       180
                  ....*....|....*....|.
gi 30180057   183 ARLGLVELDFSRGEVKKAWAA 203
Cdd:TIGR02917 399 ARTQLGISKLSQGDPSEAIAD 419
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 35-178 3.69e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.50  E-value: 3.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  35 QRALQSAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNN 114
Cdd:COG5010  14 LLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYN 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30180057 115 FGWFLCQRKpdGIEQAIGHFMAAVRdpLYETPERTYTNAGLCVLKQNDFERAQSYFQEALVIRP 178
Cdd:COG5010  94 LALLYSRSG--DKDEAKEYYEKALA--LSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
40-174 8.22e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 51.45  E-value: 8.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  40 SAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDirNNFGWFL 119
Cdd:COG4785 106 LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPE--RALWLYL 183

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 30180057 120 CQRKPDGieqaighfmAAVRDPLYETPERTYtnaglcvLKQNDFERAQSYFQEAL 174
Cdd:COG4785 184 AERKLDP---------EKALALLLEDWATAY-------LLQGDTEEARELFKLAL 222
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 55-252 1.79e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.01  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057    55 GQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFG-WFLCQRKPdgiEQAIGH 133
Cdd:TIGR02917 343 GRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGiSKLSQGDP---SEAIAD 419

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   134 F------------------------------MAAVRDPLYETPER--TYTNAGLCVLKQNDFERAQSYFQEALVIRPGYP 181
Cdd:TIGR02917 420 LetaaqldpelgradlllilsylrsgqfdkaLAAAKKLEKKQPDNasLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFF 499

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30180057   182 LARLGLVELDFSRGEVKKAWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQKRFPDSREAR 252
Cdd:TIGR02917 500 PAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPA 570
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
51-139 1.89e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.86  E-value: 1.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  51 YYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEwNFERGLGITPNDPDIRNNFGWFLCQRKpdGIEQA 130
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELG--DYDEA 78


                ....*....
gi 30180057 131 IGHFMAAVR 139
Cdd:COG3063  79 LAYLERALE 87
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 158-256 1.17e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 46.14  E-value: 1.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 158 LKQNDFERAQSYFQEALVIRPGYPL---ARLGLVELDFSRGEVKKAWAAINRYLQTYP---PAPGSLWLAVRIARANGDV 231
Cdd:COG1729   4 LKAGDYDEAIAAFKAFLKRYPNSPLapdALYWLGEAYYALGDYDEAAEAFEKLLKRYPdspKAPDALLKLGLSYLELGDY 83

                        90       100
                ....*....|....*....|....*
gi 30180057 232 NAETNYAFQLQKRFPDSREARESRA 256
Cdd:COG1729  84 DKARATLEELIKKYPDSEAAKEARA 108
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 39-251 1.44e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.93  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057    39 QSAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGWF 118
Cdd:TIGR02917 429 ELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARI 508

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   119 lcQRKPDGIEQAIGHFMAAVRdplyETPERTYTNAGLCVL--KQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGE 196
Cdd:TIGR02917 509 --DIQEGNPDDAIQRFEKVLT----IDPKNLRAILALAGLylRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQ 582

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 30180057   197 VKKAWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQKRFPDSREA 251
Cdd:TIGR02917 583 LKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALA 637
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 35-252 1.91e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057    35 QRALQSAKIHTELAGQYYHRGQYRVAIEEAEIA-LQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRN 113
Cdd:TIGR02917  84 SLGYPKNQVLPLLARAYLLQGKFQQVLDELPGKtLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKL 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   114 NFGWF-LCQRKPDG------------------------IEQAIGHFMAAV---RDPLYETPE--RTYTNAGLCVLKQNDF 163
Cdd:TIGR02917 164 GLAQLaLAENRFDEaralidevltadpgnvdalllkgdLLLSLGNIELALaayRKAIALRPNniAVLLALATILIEAGEF 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   164 ERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNYAFQLQK 243
Cdd:TIGR02917 244 EEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILK 323


                  ....*....
gi 30180057   244 RFPDSREAR 252
Cdd:TIGR02917 324 YAPNSHQAR 332
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 158-256 2.82e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.77  E-value: 2.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 158 LKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNY 237
Cdd:COG4235  28 LRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAA 107

                        90
                ....*....|....*....
gi 30180057 238 AFQLQKRFPDSREARESRA 256
Cdd:COG4235 108 WQKLLALLPADAPARLLEA 126
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 47-230 8.23e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 8.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057    47 LAGQY-YHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGWFLCQRKpd 125
Cdd:TIGR02917 198 LKGDLlLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKK-- 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   126 GIEQAIGHFMAAVR-DPLYeTPERTYtnAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAI 204
Cdd:TIGR02917 276 NYEDARETLQDALKsAPEY-LPALLL--AGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATL 352

                         170       180
                  ....*....|....*....|....*.
gi 30180057   205 NRYLQTYPPAPGSLWLAVRIARANGD 230
Cdd:TIGR02917 353 SPALGLDPDDPAALSLLGEAYLALGD 378
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 150-248 1.24e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.03  E-value: 1.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 150 YTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYPPAPGSLWLAVRIARANG 229
Cdd:COG4783  41 FALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALG 120

                        90
                ....*....|....*....
gi 30180057 230 DVNAETNYAFQLQKRFPDS 248
Cdd:COG4783 121 RPDEAIAALEKALELDPDD 139
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 51-247 1.79e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 45.75  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057    51 YYHRGQYRVAIEE---AEIALQKKTDYAP----AYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGWFLCQRk 123
Cdd:TIGR00990 402 YYHRAQLHFIKGEfaqAGKDYQKSIDLDPdfifSHIQLGVTQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLDQ- 480

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   124 pDGIEQAIGHFMAAVR-----DPLYETPERTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVK 198
Cdd:TIGR00990 481 -NKFDEAIEKFDTAIEleketKPMYMNVLPLINKALALFQWKQDFIEAENLCEKALIIDPECDIAVATMAQLLLQQGDVD 559

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 30180057   199 KAWAAINRylqtyppapgslwlAVRIARANGDVNAETNYA------FQLQKRFPD 247
Cdd:TIGR00990 560 EALKLFER--------------AAELARTEGELVQAISYAeatrtqIQVQEDYPV 600
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 39-139 1.83e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.46  E-value: 1.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  39 QSAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGWF 118
Cdd:COG4235  15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLA 94

                        90       100
                ....*....|....*....|.
gi 30180057 119 LCQRKPdgIEQAIGHFMAAVR 139
Cdd:COG4235  95 AFQQGD--YAEAIAAWQKLLA 113
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 35-112 1.37e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057  35 QRALQ----SAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPD 110
Cdd:COG4235  41 EKALRldpdNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAP 120


                ..
gi 30180057 111 IR 112
Cdd:COG4235 121 AR 122
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 40-200 1.58e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057    40 SAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPNDPDIRNNFGWFL 119
Cdd:TIGR02917 735 SSQNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLY 814

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   120 CQRK-PDGIEQAIGHF-----MAAVRDplyetperTYtnaGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFS 193
Cdd:TIGR02917 815 LELKdPRALEYAERALklapnIPAILD--------TL---GWLLVEKGEADRALPLLRKAVNIAPEAAAIRYHLALALLA 883


                  ....*..
gi 30180057   194 RGEVKKA 200
Cdd:TIGR02917 884 TGRKAEA 890
TPR_19 pfam14559
Tetratricopeptide repeat;
160-215 2.05e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 38.72  E-value: 2.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 30180057   160 QNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYPPAP 215
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDP 56
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 158-227 3.35e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 41.99  E-value: 3.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30180057   158 LKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRylqtyPPAPG--SLWLAVRIARA 227
Cdd:PRK11447  614 QQRGDYAAARAAYQRVLTREPGNADARLGLIEVDIAQGDLAAARAQLAK-----LPATAndSLNTQRRVALA 680
OM_YfiO TIGR03302
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 140-256 3.66e-04

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 40.61  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   140 DPLYETPERTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVEL---DFSRGEVKKAWAAINRYLQTYPPAPG 216
Cdd:TIGR03302  26 DPVEEWPAEELYEEAKEALDSGDYTEAIKYFEALESRYPFSPYAEQAQLDLayaYYKSGDYAEAIAAADRFIRLHPNHPD 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 30180057   217 SLWLAVRIARANGD------------VNAETNYAfQLQKRFPDSREARESRA 256
Cdd:TIGR03302 106 ADYAYYLRGLSNYNqidrvdrdqtaaREAFEAFQ-ELIRRYPNSEYAPDAKK 156
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
158-250 3.88e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.61  E-value: 3.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 158 LKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAwAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNY 237
Cdd:COG3063   3 LKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81

                        90
                ....*....|...
gi 30180057 238 AFQLQKRFPDSRE 250
Cdd:COG3063  82 LERALELDPSALR 94
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
128-230 6.73e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.90  E-value: 6.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 128 EQAIGHFMAAVR-DPLYEtpeRTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINR 206
Cdd:COG4785  90 DLAIADFDQALElDPDLA---EAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEK 166

                        90       100
                ....*....|....*....|....*
gi 30180057 207 YLQTYPPAPG-SLWLAVRIARANGD 230
Cdd:COG4785 167 ALELDPNDPErALWLYLAERKLDPE 191
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
35-107 9.55e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 9.55e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30180057  35 QRALQ----SAKIHTELAGQYYHRGQYRVAIEeAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPN 107
Cdd:COG3063  16 EKALEldpdNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 158-256 1.68e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 1.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 158 LKQNDFERAQSYFQEALVIRPGYPLARLGLVELDFSRGEVKKAWAAINRYLQTYPPAPGSLWLAVRIARANGDVNAETNY 237
Cdd:COG4783  15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALAL 94

                        90
                ....*....|....*....
gi 30180057 238 AFQLQKRFPDSREARESRA 256
Cdd:COG4783  95 LEKALKLDPEHPEAYLRLA 113
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 31-108 2.14e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.48  E-value: 2.14e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30180057  31 EELKQRALQSAKIHTELAGQYYHRGQYRVAIEEAEIALQKKTDYAPAYNMLGLVYMDLQEDDRAEWNFERGLGITPND 108
Cdd:COG4783  62 HEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 158-215 2.39e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.77  E-value: 2.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30180057   158 LKQNDFERAQSYFQEALVIRPGYPL---ARLGLVELDFSRGEVKKAWAAINRYLQTYPPAP 215
Cdd:pfam13432   8 LRAGDYDDAAAALEAALARFPESPDaaaALLLLGLAALRQGRLAEAAAAYRAALRAAPGDP 68
YfiO pfam13525
Outer membrane lipoprotein; This outer membrane lipoprotein carries a TPR-like region towards ...
 145-256 5.50e-03

Outer membrane lipoprotein; This outer membrane lipoprotein carries a TPR-like region towards its N-terminal. YfiO in E.coli is one of three outer membrane lipoproteins that form a multicomponent YaeT complex in the outer membrane of Gram-negative bacteria that is involved in the targeting and folding of beta-barrel outer membrane proteins. YfiO is the only essential lipoprotein component of the complex. It is required for the proper assembly and/or targeting of outer membrane proteins to the outer membrane. Through its interactions with NlpB it maintains the functional integrity of the YaeT complex.


Pssm-ID: 433282 [Multi-domain]  Cd Length: 200  Bit Score: 36.92  E-value: 5.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057   145 TPERTYTnAGLCVLKQNDFERAQSYFQEALVIRPGYPL---ARLGLVELDFSRGEVKKAWAAINRYLQTYPPAP------ 215
Cdd:pfam13525   3 PASELYE-AGQTALQKGDYGDAIKKLEALDNRYPFSPYaeqAQLDLIYAYYKDADYADALAAAERFLRLYPTHPnidyvy 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 30180057   216 ---GSLWLAV--RIARANGDVNAET---NYAFQLQKRFPDSREARESRA 256
Cdd:pfam13525  82 ymrGLSNFAQdrDFFRSDRDPESARqafEDFATLIRKYPDSEYATDAEQ 130
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 136-256 6.18e-03

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 37.17  E-value: 6.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30180057 136 AAVRDPLYETPERTYTNAGLCVLKQNDFERAQSYFQEALVIRPGYPLARLGLVEL---DFSRGEVKKAWAAINRYLQTYP 212
Cdd:COG4105  21 SSFKKALKSWDAEELYEEAKEALEKGDYEKAIKLFEELEPRYPGSPYAEQAQLMLayaYYKQGDYEEAIAAADRFIKLYP 100

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 30180057 213 PAPGSLWLAVRIARAN----GDVN---AETNYAF----QLQKRFPDSREARESRA 256
Cdd:COG4105 101 NSPNADYAYYLRGLSYyeqsPDSDrdqTSTRKAIeafqELINRYPDSEYAEDAKK 155
Menin cd14456
Scaffolding protein menin encoded by the MEN1 gene; MEN1 is the gene responsible for multiple ...
 20-62 8.45e-03

Scaffolding protein menin encoded by the MEN1 gene; MEN1 is the gene responsible for multiple endocrine neoplasia type 1, and it has been characterized as a tumor suppressor gene that encodes a protein called menin. Menin is mostly found in the nucleus and can regulate gene expression in a positive and in a negative way, and it has been shown to interact with transcription activators, transcription repressors, cell signaling proteins, and various other proteins. It plays major roles in DNA repair, the regulation of the cell cycle, and chromatin remodeling.


Pssm-ID: 271218  Cd Length: 437  Bit Score: 37.23  E-value: 8.45e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 30180057  20 GHAPVQEKPTPEELKQRALQSAKIH---------TELAGQYYHRGQYRVAIE 62
Cdd:cd14456 279 EISPTPGRPPCLKLFNEAISSARKYyrnhhvypyTYLGGYYYRHGKYREALR 330
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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