NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1975448569|emb|CAE3241560|]
View 

unnamed protein product, partial [Hemiselmis andersenii]

Protein Classification

DEXDc domain-containing protein( domain architecture ID 10447116)

DEXDc domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 171-345 1.80e-28

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


:

Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 108.87  E-value: 1.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 171 RPIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAF 250
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 251 ADRSDRGGGNYVNTTQIVIATAGQLNFMLKKgTIPTKDLKLVIADEVDDIFSQksdGRTDGTDqiisqiiQRIERQRRRP 330
Cdd:pfam00270  81 GGDSRKEQLEKLKGPDILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDM---GFGPDLE-------EILRRLPKKR 149

                         170
                  ....*....|....*
gi 1975448569 331 QILFFSATIGDDALD 345
Cdd:pfam00270 150 QILLLSATLPRNLED 164
 
Name Accession Description Interval E-value
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 171-345 1.80e-28

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 108.87  E-value: 1.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 171 RPIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAF 250
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 251 ADRSDRGGGNYVNTTQIVIATAGQLNFMLKKgTIPTKDLKLVIADEVDDIFSQksdGRTDGTDqiisqiiQRIERQRRRP 330
Cdd:pfam00270  81 GGDSRKEQLEKLKGPDILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDM---GFGPDLE-------EILRRLPKKR 149

                         170
                  ....*....|....*
gi 1975448569 331 QILFFSATIGDDALD 345
Cdd:pfam00270 150 QILLLSATLPRNLED 164
DEXDc smart00487
DEAD-like helicases superfamily;
163-362 1.50e-25

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 102.18  E-value: 1.50e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569  163 NEQGQFTVRPIQAATLPVSLAG-HNLVATAETGSGKTMCFATVALAAVsKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTS 241
Cdd:smart00487   2 EKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEAL-KRGKGGRVLVLVPTRELAEQWAEELKKLGPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569  242 LNNQVTCAF--ADRSDRGGGNYVNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIfsqKSDGRTDgtdqiisQI 319
Cdd:smart00487  81 LGLKVVGLYggDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRL---LDGGFGD-------QL 150

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1975448569  320 IQRIERQRRRPQILFFSATIGDDALDPDDRALRNMIEHCVGRR 362
Cdd:smart00487 151 EKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFT 193
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 172-353 2.31e-25

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 101.75  E-value: 2.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPC----PQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVT 247
Cdd:cd00268    15 PIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKkgrgPQALVLAPTRELAMQIAEVARKLGKGTGLKVA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 248 CAFadrsdrGGGNY-------VNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD------------DIFSQKSDGR 308
Cdd:cd00268    95 AIY------GGAPIkkqiealKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADrmldmgfeedveKILSALPKDR 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1975448569 309 tdgtdqiisqiiqrierqrrrpQILFFSATIGDDALDPDDRALRN 353
Cdd:cd00268   169 ----------------------QTLLFSATLPEEVKELAKKFLKN 191
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
172-339 3.03e-21

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 94.44  E-value: 3.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKP-CPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAF 250
Cdd:COG0513    27 PIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPrAPQALILAPTRELALQVAEELRKLAKYLGLRVATVY 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 251 adrsdrGGGNYV-------NTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD------------DIFSQKSDGRtdg 311
Cdd:COG0513   107 ------GGVSIGrqiralkRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADrmldmgfiedieRILKLLPKER--- 177

                         170       180
                  ....*....|....*....|....*...
gi 1975448569 312 tdqiisqiiqrierqrrrpQILFFSATI 339
Cdd:COG0513   178 -------------------QTLLFSATM 186
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 172-298 9.31e-14

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 72.14  E-value: 9.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNN-QVT--C 248
Cdd:PRK11776   29 PIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTRELADQVAKEIRRLARFIPNiKVLtlC 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1975448569 249 afadrsdrGG-------GNYVNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:PRK11776  109 --------GGvpmgpqiDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEAD 157
 
Name Accession Description Interval E-value
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 171-345 1.80e-28

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 108.87  E-value: 1.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 171 RPIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAF 250
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 251 ADRSDRGGGNYVNTTQIVIATAGQLNFMLKKgTIPTKDLKLVIADEVDDIFSQksdGRTDGTDqiisqiiQRIERQRRRP 330
Cdd:pfam00270  81 GGDSRKEQLEKLKGPDILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDM---GFGPDLE-------EILRRLPKKR 149

                         170
                  ....*....|....*
gi 1975448569 331 QILFFSATIGDDALD 345
Cdd:pfam00270 150 QILLLSATLPRNLED 164
DEXDc smart00487
DEAD-like helicases superfamily;
163-362 1.50e-25

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 102.18  E-value: 1.50e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569  163 NEQGQFTVRPIQAATLPVSLAG-HNLVATAETGSGKTMCFATVALAAVsKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTS 241
Cdd:smart00487   2 EKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEAL-KRGKGGRVLVLVPTRELAEQWAEELKKLGPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569  242 LNNQVTCAF--ADRSDRGGGNYVNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIfsqKSDGRTDgtdqiisQI 319
Cdd:smart00487  81 LGLKVVGLYggDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRL---LDGGFGD-------QL 150

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1975448569  320 IQRIERQRRRPQILFFSATIGDDALDPDDRALRNMIEHCVGRR 362
Cdd:smart00487 151 EKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFT 193
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 172-353 2.31e-25

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 101.75  E-value: 2.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPC----PQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVT 247
Cdd:cd00268    15 PIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKkgrgPQALVLAPTRELAMQIAEVARKLGKGTGLKVA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 248 CAFadrsdrGGGNY-------VNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD------------DIFSQKSDGR 308
Cdd:cd00268    95 AIY------GGAPIkkqiealKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADrmldmgfeedveKILSALPKDR 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1975448569 309 tdgtdqiisqiiqrierqrrrpQILFFSATIGDDALDPDDRALRN 353
Cdd:cd00268   169 ----------------------QTLLFSATLPEEVKELAKKFLKN 191
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 173-341 3.46e-22

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 93.02  E-value: 3.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 173 IQAATLPVSLAG--HNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAF 250
Cdd:cd17963    20 IQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQIGEVVEKMGKFTGVKVALAV 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 251 ADRSDRGGGNYVNttQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQksDGRTDgtdqiisQIIQRIERQRRRP 330
Cdd:cd17963   100 PGNDVPRGKKITA--QIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDT--QGHGD-------QSIRIKRMLPRNC 168

                         170
                  ....*....|.
gi 1975448569 331 QILFFSATIGD 341
Cdd:cd17963   169 QILLFSATFPD 179
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
172-339 3.03e-21

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 94.44  E-value: 3.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKP-CPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAF 250
Cdd:COG0513    27 PIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPrAPQALILAPTRELALQVAEELRKLAKYLGLRVATVY 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 251 adrsdrGGGNYV-------NTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD------------DIFSQKSDGRtdg 311
Cdd:COG0513   107 ------GGVSIGrqiralkRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADrmldmgfiedieRILKLLPKER--- 177

                         170       180
                  ....*....|....*....|....*...
gi 1975448569 312 tdqiisqiiqrierqrrrpQILFFSATI 339
Cdd:COG0513   178 -------------------QTLLFSATM 186
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 172-298 5.67e-19

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 83.85  E-value: 5.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAFA 251
Cdd:cd17943    15 PIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKKIGKKLEGLKCEVFI 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1975448569 252 drsdrgGGNYVNT-------TQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:cd17943    95 ------GGTPVKEdkkklkgCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEAD 142
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
 172-298 2.94e-16

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 76.64  E-value: 2.94e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPC-----PQVLIMAHNRPLLDQLCDEMEKLCTSLNNQV 246
Cdd:cd17966    15 AIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLergdgPIVLVLAPTRELAQQIQQEANKFGGSSRLRN 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 247 TCAF--ADRS------DRGggnyvntTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:cd17966    95 TCVYggAPKGpqirdlRRG-------VEICIATPGRLIDFLDQGKTNLRRVTYLVLDEAD 147
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
 172-302 8.91e-15

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 72.06  E-value: 8.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVS-----KTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQV 246
Cdd:cd17952    15 PIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMdqrelEKGEGPIAVIVAPTRELAQQIYLEAKKFGKAYNLRV 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1975448569 247 TCAFadrsdrGGGNYVNTTQ-------IVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFS 302
Cdd:cd17952    95 VAVY------GGGSKWEQAKalqegaeIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFD 151
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
 172-302 1.64e-14

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 71.85  E-value: 1.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFA------TVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQ 245
Cdd:cd17961    19 LIQSKAIPLALEGKDILARARTGSGKTAAYAlpiiqkILKAKAESGEEQGTRALILVPTRELAQQVSKVLEQLTAYCRKD 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1975448569 246 VTCA-FADRSDRGGGNYV--NTTQIVIATAGQLNFMLKKGTIPTKD-LKLVIADEVDDIFS 302
Cdd:cd17961    99 VRVVnLSASSSDSVQRALlaEKPDIVVSTPARLLSHLESGSLLLLStLKYLVIDEADLVLS 159
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
 172-298 1.91e-14

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 71.75  E-value: 1.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKP----------CPQVLIMAHNRPLLDQLCDEMEKLCts 241
Cdd:cd17967    25 PVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPpsvgrgrrkaYPSALILAPTRELAIQIYEEARKFS-- 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1975448569 242 LNNQVTCAFAdrsdrGGGNYVNTTQ--------IVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:cd17967   103 YRSGVRSVVV-----YGGADVVHQQlqllrgcdILVATPGRLVDFIERGRISLSSIKFLVLDEAD 162
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
 172-356 2.59e-14

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 71.17  E-value: 2.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPL---LDQLCDEMEKlctSLNNQVTC 248
Cdd:cd17940    24 PIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELalqTSQVCKELGK---HMGVKVMV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 249 AFADRSDRGGGNYV-NTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQKSDGRTDgtdqiisqiiQRIERQR 327
Cdd:cd17940   101 TTGGTSLRDDIMRLyQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQDFQPIIE----------KILNFLP 170

                         170       180
                  ....*....|....*....|....*....
gi 1975448569 328 RRPQILFFSATIGDDALDPDDRALRNMIE 356
Cdd:cd17940   171 KERQILLFSATFPLTVKNFMDRHMHNPYE 199
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
 172-301 3.05e-14

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 70.70  E-value: 3.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAV--SKTKPCPQVLIMAHNRPLLDQLCDEMEKLCtsLNNQVTCA 249
Cdd:cd17957    15 PIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLgkPRKKKGLRALILAPTRELASQIYRELLKLS--KGTGLRIV 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1975448569 250 FADRSDRGGGNYV----NTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIF 301
Cdd:cd17957    93 LLSKSLEAKAKDGpksiTKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLF 148
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
 172-298 4.53e-14

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 70.81  E-value: 4.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPC--------PQVLIMAHNRPLLDQLCDEMEKLCTSLN 243
Cdd:cd17945    15 PIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLdeetkddgPYALILAPTRELAQQIEEETQKFAKPLG 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1975448569 244 NQVTCAFADRSDRGGGNYV-NTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:cd17945    95 IRVVSIVGGHSIEEQAFSLrNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEAD 150
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
 172-338 7.02e-14

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 70.35  E-value: 7.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHN---------LVATAETGSGKTMCFATVALAAVSK-TKPCPQVLIMAHNRPLLDQLCDEMEKLCTS 241
Cdd:cd17956    15 PVQAAVIPWLLPSSKstppyrpgdLCVSAPTGSGKTLAYVLPIVQALSKrVVPRLRALIVVPTKELVQQVYKVFESLCKG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 242 LNNQVTCAFADRSDRG---------GGNYVNTTQIVIATAGQL--------NFMLKKgtiptkdLKLVIADEVDDIFSQ- 303
Cdd:cd17956    95 TGLKVVSLSGQKSFKKeqklllvdtSGRYLSRVDILVATPGRLvdhlnstpGFTLKH-------LRFLVIDEADRLLNQs 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1975448569 304 ---------KSDGRTDGTDQIISQIIQRIERQRRRPQILFFSAT 338
Cdd:cd17956   168 fqdwletvmKALGRPTAPDLGSFGDANLLERSVRPLQKLLFSAT 211
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 172-298 9.31e-14

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 72.14  E-value: 9.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNN-QVT--C 248
Cdd:PRK11776   29 PIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTRELADQVAKEIRRLARFIPNiKVLtlC 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1975448569 249 afadrsdrGG-------GNYVNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:PRK11776  109 --------GGvpmgpqiDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEAD 157
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 184-338 1.31e-13

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 67.43  E-value: 1.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 184 GHNLVATAETGSGKTMCFATVALAAVSKTKpcPQVLIMAHNRPLLDQLCDEMEKLctsLNNQVTCAFADRSDRGGGNYVN 263
Cdd:cd00046     1 GENVLITAPTGSGKTLAALLAALLLLLKKG--KKVLVLVPTKALALQTAERLREL---FGPGIRVAVLVGGSSAEEREKN 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1975448569 264 TTQ---IVIATAGQLNFMLK-KGTIPTKDLKLVIADEVDDIfsqksDGRTDGTDqiiSQIIQRIERQRRRPQILFFSAT 338
Cdd:cd00046    76 KLGdadIIIATPDMLLNLLLrEDRLFLKDLKLIIVDEAHAL-----LIDSRGAL---ILDLAVRKAGLKNAQVILLSAT 146
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
 174-356 1.41e-13

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 68.89  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 174 QAATLPVSLaGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAFadr 253
Cdd:cd17939    25 QRAIVPIIK-GRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQIQKVVKALGDYMGVKVHACI--- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 254 sdrGGGNYVNT-------TQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQksdGRTDgtdqiisQIIQRIERQ 326
Cdd:cd17939   101 ---GGTSVREDrrklqygPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSR---GFKD-------QIYDIFQFL 167

                         170       180       190
                  ....*....|....*....|....*....|
gi 1975448569 327 RRRPQILFFSATIGDDALDPDDRALRNMIE 356
Cdd:cd17939   168 PPETQVVLFSATMPHEVLEVTKKFMRDPVR 197
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
 172-298 1.94e-13

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 68.26  E-value: 1.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVAL------AAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLctSLNN- 244
Cdd:cd17958    15 PIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFihldlqPIPREQRNGPGVLVLTPTRELALQIEAECSKY--SYKGl 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1975448569 245 QVTCAFadrsdrGGGNYVNT-------TQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:cd17958    93 KSVCVY------GGGNRNEQiedlskgVDIIIATPGRLNDLQMNNVINLKSITYLVLDEAD 147
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
 172-298 6.90e-13

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 66.80  E-value: 6.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAFA 251
Cdd:cd17962    15 PIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKELMKGLPPMKTALLV 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1975448569 252 DRSDRGGGNY--VNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:cd17962    95 GGLPLPPQLYrlQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEAD 143
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
 173-343 3.38e-12

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 65.06  E-value: 3.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 173 IQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAFAd 252
Cdd:cd17950    28 VQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTRELAFQISNEYERFSKYMPNVKTAVFF- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 253 rsdrGGGNY--------VNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQkSDGRTDGTDQIISQIIQRie 324
Cdd:cd17950   107 ----GGVPIkkdievlkNKCPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLEQ-LDMRRDVQEIFRATPHDK-- 179

                         170
                  ....*....|....*....
gi 1975448569 325 rqrrrpQILFFSATIGDDA 343
Cdd:cd17950   180 ------QVMMFSATLSKEI 192
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
 171-341 4.07e-12

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 65.43  E-value: 4.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 171 RP--IQAATLPVSLAG--HNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQ---LCDEMEKLCtsln 243
Cdd:cd18048    40 RPskIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQCLCLSPTFELALQtgkVVEEMGKFC---- 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 244 NQVTCAFADRSDRGGGNYVNTTQIVIATAGQ-LNFMLKKGTIPTKDLKLVIADEVDDIFSQKsdGRTDGTdqiisqiIQR 322
Cdd:cd18048   116 VGIQVIYAIRGNRPGKGTDIEAQIVIGTPGTvLDWCFKLRLIDVTNISVFVLDEADVMINVQ--GHSDHS-------VRV 186

                         170
                  ....*....|....*....
gi 1975448569 323 IERQRRRPQILFFSATIGD 341
Cdd:cd18048   187 KRSMPKECQMLLFSATFED 205
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
 172-298 5.03e-12

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 64.53  E-value: 5.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLA-GHNLVATAETGSGKTMCFATVALAAVSKTKPCPQ-----VLIMAHNRPLLDQLCDEMEKLCTSLNN- 244
Cdd:cd17964    19 PVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRrsgvsALIISPTRELALQIAAEAKKLLQGLRKl 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1975448569 245 QVTCAFADRSDRGGGNYVNT--TQIVIATAGQLNFMLK--KGTIPTKDLKLVIADEVD 298
Cdd:cd17964    99 RVQSAVGGTSRRAELNRLRRgrPDILVATPGRLIDHLEnpGVAKAFTDLDYLVLDEAD 156
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
 172-302 5.58e-12

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 64.26  E-value: 5.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAFa 251
Cdd:cd17954    25 KIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFALVLAPTRELAQQISEQFEALGSSIGLKSAVLV- 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 252 drsdrGGGNYVNTT-------QIVIATAGQLNFMLK--KGtIPTKDLKLVIADEVDDIFS 302
Cdd:cd17954   104 -----GGMDMMAQAialakkpHVIVATPGRLVDHLEntKG-FSLKSLKFLVMDEADRLLN 157
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
 172-301 5.89e-12

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 64.71  E-value: 5.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPC-----PQVLIMAHNRPLLDQLCDEMEKLCTSLNNQV 246
Cdd:cd17953    37 PIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPVkpgegPIGLIMAPTRELALQIYVECKKFSKALGLRV 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1975448569 247 TCAFadrsdrgGGNYVN--------TTQIVIATAGQLNFML--KKGTIPT-KDLKLVIADEVDDIF 301
Cdd:cd17953   117 VCVY-------GGSGISeqiaelkrGAEIVVCTPGRMIDILtaNNGRVTNlRRVTYVVLDEADRMF 175
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
 172-301 7.28e-12

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 66.15  E-value: 7.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVAL-------AAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNN 244
Cdd:PRK04837   33 PIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFhyllshpAPEDRKVNQPRALIMAPTRELAVQIHADAEPLAQATGL 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1975448569 245 QVTCAFadrsdrGGGNY-------VNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIF 301
Cdd:PRK04837  113 KLGLAY------GGDGYdkqlkvlESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMF 170
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
 172-300 8.90e-12

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 66.41  E-value: 8.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLN--NQVTCA 249
Cdd:PRK11634   31 PIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRELAVQVAEAMTDFSKHMRgvNVVALY 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1975448569 250 FADRSD------RGGgnyvntTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDI 300
Cdd:PRK11634  111 GGQRYDvqlralRQG------PQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEM 161
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
 164-303 1.68e-11

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 62.76  E-value: 1.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 164 EQGQFTVRPIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQ----VLIMAHNRPLLDQLCDEMEKLC 239
Cdd:cd17942     7 EMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPRngtgVIIISPTRELALQIYGVAKELL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1975448569 240 TslNNQVTCAFAdrsdRGGGN-------YVNTTQIVIATAGQ-LNFMLKKGTIPTKDLKLVIADEVDDIFSQ 303
Cdd:cd17942    87 K--YHSQTFGIV----IGGANrkaeaekLGKGVNILVATPGRlLDHLQNTKGFLYKNLQCLIIDEADRILEI 152
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
 172-298 4.26e-11

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 62.68  E-value: 4.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCF----------ATVALAAVSKTKPcPQVLIMAHNRPLLDQLCDEMEKLC-- 239
Cdd:cd18052    68 PVQKYAIPIILAGRDLMACAQTGSGKTAAFllpvltgmmkEGLTASSFSEVQE-PQALIVAPTRELANQIFLEARKFSyg 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 240 -----------TSLNNQvtcafADRSDRGggnyvntTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:cd18052   147 tcirpvvvyggVSVGHQ-----IRQIEKG-------CHILVATPGRLLDFIGRGKISLSKLKYLILDEAD 204
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
 174-355 9.51e-11

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 60.54  E-value: 9.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 174 QAATLPVsLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQV-TCAfad 252
Cdd:cd18046    27 QRAIMPC-IKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELAQQIQKVVMALGDYMGIKChACI--- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 253 rsdrGGGNYVNTTQ-------IVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQksdGRTDgtdqiisQIIQRIER 325
Cdd:cd18046   103 ----GGTSVRDDAQklqagphIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSR---GFKD-------QIYDIFQK 168

                         170       180       190
                  ....*....|....*....|....*....|
gi 1975448569 326 QRRRPQILFFSATIGDDALDPDDRALRNMI 355
Cdd:cd18046   169 LPPDTQVVLLSATMPNDVLEVTTKFMRDPI 198
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
 171-341 1.22e-10

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 60.32  E-value: 1.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 171 RPIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNnqVTCAF 250
Cdd:cd17955    23 TPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRELAYQIAEQFRALGAPLG--LRCCV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 251 AdrsdRGGGNYVNTTQ-------IVIATAGQLNFMLKKGTIPTKDLKLV---------------IADEVDDIFSQKSDGR 308
Cdd:cd17955   101 I----VGGMDMVKQALelskrphIVVATPGRLADHLRSSDDTTKVLSRVkflvldeadrlltgsFEDDLATILSALPPKR 176

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1975448569 309 tdgtdqiisqiiqrierqrrrpQILFFSATIGD 341
Cdd:cd17955   177 ----------------------QTLLFSATLTD 187
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
 172-357 1.57e-10

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 60.25  E-value: 1.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVS------KTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNnq 245
Cdd:cd17944    15 PIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQedqqprKRGRAPKVLVLAPTRELANQVTKDFKDITRKLS-- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 246 VTCAFADRSDRGGGNYV-NTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQksdGRTDGTDqiISQIIQRIE 324
Cdd:cd17944    93 VACFYGGTPYQQQIFAIrNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDM---GFAEQVE--EILSVSYKK 167

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1975448569 325 RQRRRPQILFFSATIGDDALDPDDRALRNMIEH 357
Cdd:cd17944   168 DSEDNPQTLLFSATCPDWVYNVAKKYMKSQYEQ 200
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
 172-301 1.96e-10

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 60.46  E-value: 1.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTK-------PCPQVLIMAHNRPLLDQLCDEMEKLCTSLNN 244
Cdd:cd17948    15 TVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKllaegpfNAPRGLVITPSRELAEQIGSVAQSLTEGLGL 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1975448569 245 QVTCAfadrsdrGGGNYVNT--------TQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIF 301
Cdd:cd17948    95 KVKVI-------TGGRTKRQirnphfeeVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLL 152
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
 174-303 3.19e-10

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 59.02  E-value: 3.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 174 QAATLPVsLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAFadr 253
Cdd:cd18045    27 QRAIKPI-IKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELAVQIQKVLLALGDYMNVQCHACI--- 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1975448569 254 sdrgGGNYVNT--------TQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQ 303
Cdd:cd18045   103 ----GGTSVGDdirkldygQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNK 156
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
 172-298 3.95e-10

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 59.56  E-value: 3.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLA-GHNLVATAETGSGKTMCFATVALA---------AVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTS 241
Cdd:cd17946    15 PIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILErllsqkssnGVGGKQKPLRALILTPTRELAVQVKDHLKAIAKY 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1975448569 242 LNNQVTCAFadrsdrgGGNYVNTTQ--------IVIATAGQLNFMLKKGTIPTKDLK----LVIaDEVD 298
Cdd:cd17946    95 TNIKIASIV-------GGLAVQKQErllkkrpeIVVATPGRLWELIQEGNEHLANLKslrfLVL-DEAD 155
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
 166-298 4.24e-10

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 58.74  E-value: 4.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 166 GQFTvrPIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPC---PQV--LIMAHNRPLLDQLCDEMEKLCT 240
Cdd:cd17960    11 TSMT--PVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANlkkGQVgaLIISPTRELATQIYEVLQSFLE 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 241 SLNNQVTCAFA----------DRSDRGGGNyvnttqIVIATAGQLNFML--KKGTIPTKDLKLVIADEVD 298
Cdd:cd17960    89 HHLPKLKCQLLiggtnveedvKKFKRNGPN------ILVGTPGRLEELLsrKADKVKVKSLEVLVLDEAD 152
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
 172-298 5.89e-10

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 58.42  E-value: 5.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAV---SKTKPCPQVLIMAHNRPLLDQlCDEMEKLCTSLNNqVTC 248
Cdd:cd17947    15 PIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLlyrPKKKAATRVLVLVPTRELAMQ-CFSVLQQLAQFTD-ITF 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1975448569 249 AFAdrsdrGGGNYVNTTQ--------IVIATAGQLNFMLKKG-TIPTKDLKLVIADEVD 298
Cdd:cd17947    93 ALA-----VGGLSLKAQEaalrarpdIVIATPGRLIDHLRNSpSFDLDSIEILVLDEAD 146
PTZ00110 PTZ00110
helicase; Provisional
 172-298 1.84e-09

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 59.02  E-value: 1.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCF---ATVALAAVSKTKP--CPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQV 246
Cdd:PTZ00110  155 PIQVQGWPIALSGRDMIGIAETGSGKTLAFllpAIVHINAQPLLRYgdGPIVLVLAPTRELAEQIREQCNKFGASSKIRN 234

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1975448569 247 TCAFADRSDRGGGNYV-NTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:PTZ00110  235 TVAYGGVPKRGQIYALrRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEAD 287
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
183-297 4.99e-09

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 57.73  E-value: 4.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 183 AGHNLVATAETGSGKTmcfaTVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKlctslnnqvtcaFADRSDRGGGNYV 262
Cdd:COG1061    99 GGGRGLVVAPTGTGKT----VLALALAAELLRGKRVLVLVPRRELLEQWAEELRR------------FLGDPLAGGGKKD 162

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1975448569 263 NTTQIVIATAGQLNFMLKKGTIPtKDLKLVIADEV 297
Cdd:COG1061   163 SDAPITVATYQSLARRAHLDELG-DRFGLVIIDEA 196
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
 164-301 7.53e-09

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 57.27  E-value: 7.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 164 EQGQFT-VRPIQAATLPVSLAGHNLVATAETGSGKTMCFATVAL------AAVSKTKP-CPQVLIMAHNRPLLDQLCDEM 235
Cdd:PRK04537   25 ESAGFTrCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMnrllsrPALADRKPeDPRALILAPTRELAIQIHKDA 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1975448569 236 EKLCTSLNNQVTCAFadrsdrGGGNYVNTTQI-------VIATAGQL-NFMLKKGTIPTKDLKLVIADEVDDIF 301
Cdd:PRK04537  105 VKFGADLGLRFALVY------GGVDYDKQRELlqqgvdvIIATPGRLiDYVKQHKVVSLHACEICVLDEADRMF 172
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
 172-303 2.64e-08

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 53.48  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVsktkpcpQVLIMAHNRPLLDQLCDEMEKLCTSLNN-QVTCAF 250
Cdd:cd17938    24 DIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIV-------VALILEPSRELAEQTYNCIENFKKYLDNpKLRVAL 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1975448569 251 ---------ADRSDRGGGNyvnttqIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQ 303
Cdd:cd17938    97 liggvkareQLKRLESGVD------IVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQ 152
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 164-300 5.56e-08

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 52.68  E-value: 5.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 164 EQGQFT-VRPIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQ----VLIMAHNRPLLDQLCDEMEKL 238
Cdd:cd17941     6 KEAGFIkMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEdglgALIISPTRELAMQIFEVLRKV 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1975448569 239 CTslNNQVTCAFAdrsdRGGGNY------VNTTQIVIATAGQ-LNFMLKKGTIPTKDLKLVIADEVDDI 300
Cdd:cd17941    86 GK--YHSFSAGLI----IGGKDVkeekerINRMNILVCTPGRlLQHMDETPGFDTSNLQMLVLDEADRI 148
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
 172-301 5.75e-08

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 52.69  E-value: 5.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFatvALAAVSKTK-PCPQV----LIMAHNRPLLDQLCDEMEKLC--TSLnn 244
Cdd:cd17959    26 PIQRKTIPLILDGRDVVAMARTGSGKTAAF---LIPMIEKLKaHSPTVgaraLILSPTRELALQTLKVTKELGkfTDL-- 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1975448569 245 qVTCAF--ADRSDRGGGNYVNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIF 301
Cdd:cd17959   101 -RTALLvgGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRLF 158
PTZ00424 PTZ00424
helicase 45; Provisional
 173-303 6.12e-08

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 54.06  E-value: 6.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 173 IQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLcdemeklctslnNQVTCAFAD 252
Cdd:PTZ00424   54 IQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELAQQI------------QKVVLALGD 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1975448569 253 RSDRG-----GGNYV--------NTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQ 303
Cdd:PTZ00424  122 YLKVRchacvGGTVVrddinklkAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSR 185
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
 172-298 1.09e-07

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 52.32  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKtKPC------PQVLIMAHNRPLLDQLCDEMEKLCTSLNNQ 245
Cdd:cd18049    49 AIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINH-QPFlergdgPICLVLAPTRELAQQVQQVAAEYGRACRLK 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1975448569 246 VTCAFADRS--------DRGggnyvntTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:cd18049   128 STCIYGGAPkgpqirdlERG-------VEICIATPGRLIDFLEAGKTNLRRCTYLVLDEAD 181
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 171-298 1.10e-07

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 53.41  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 171 RP--IQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVS---KTKPCP-QVLIMAHNRPLLDQLCDEMEKLC--TSL 242
Cdd:PRK11192   23 RPtaIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLdfpRRKSGPpRILILTPTRELAMQVADQARELAkhTHL 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1975448569 243 N-NQVTcafadrsdrGGGNYVN------TTQ-IVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:PRK11192  103 DiATIT---------GGVAYMNhaevfsENQdIVVATPGRLLQYIKEENFDCRAVETLILDEAD 157
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
 172-298 2.15e-07

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 50.80  E-value: 2.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFA-TVALAAVSKTKPCPQV-------LIMAHNRPLLDQLCDEMEKLCTSLN 243
Cdd:cd17951    15 PIQMQGLPTILSGRDMIGIAFTGSGKTLVFTlPLIMFALEQEKKLPFIkgegpygLIVCPSRELARQTHEVIEYYCKALQ 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1975448569 244 N----QVTCAFAdrsdRGGGNYVNTTQ-------IVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:cd17951    95 EggypQLRCLLC----IGGMSVKEQLEvirkgvhIVVATPGRLMDMLNKKKINLDICRYLCLDEAD 156
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
 171-341 3.53e-07

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 50.49  E-value: 3.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 171 RP--IQAATLPVSLAG--HNLVATAETGSGKTMCFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLcTSLNNQV 246
Cdd:cd18047    23 RPskIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGKVIEQM-GKFYPEL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 247 TCAFADRSDRGGGNYVNTTQIVIATAGQ-LNFMLKKGTIPTKDLKLVIADEVDDIFSqkSDGRTDGTdqiisqiIQRIER 325
Cdd:cd18047   102 KLAYAVRGNKLERGQKISEQIVIGTPGTvLDWCSKLKFIDPKKIKVFVLDEADVMIA--TQGHQDQS-------IRIQRM 172

                         170
                  ....*....|....*.
gi 1975448569 326 QRRRPQILFFSATIGD 341
Cdd:cd18047   173 LPRNCQMLLFSATFED 188
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
 172-339 4.35e-07

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 51.71  E-value: 4.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCF--------ATVALAAVSKTKPcPQVLIMAHNRPLLDQLCDEMEKLCTSLN 243
Cdd:PLN00206  146 PIQMQAIPAALSGRSLLVSADTGSGKTASFlvpiisrcCTIRSGHPSEQRN-PLAMVLTPTRELCVQVEDQAKVLGKGLP 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 244 NQVTCAFadrsdrgGGNYV--------NTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQksdGRTDgtdqi 315
Cdd:PLN00206  225 FKTALVV-------GGDAMpqqlyriqQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLER---GFRD----- 289

                         170       180
                  ....*....|....*....|....
gi 1975448569 316 isqIIQRIERQRRRPQILFFSATI 339
Cdd:PLN00206  290 ---QVMQIFQALSQPQVLLFSATV 310
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 172-297 7.62e-07

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 48.80  E-value: 7.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATL-PVSLAGHNLVATAETGSGKTMC--FATVALAAVSKTKpcpqVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTC 248
Cdd:cd17921     4 PIQREALrALYLSGDSVLVSAPTSSGKTLIaeLAILRALATSGGK----AVYIAPTRALVNQKEADLRERFGPLGKNVGL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1975448569 249 AFADRSDRggGNYVNTTQIVIATAGQLNFMLKKGTIP-TKDLKLVIADEV 297
Cdd:cd17921    80 LTGDPSVN--KLLLAEADILVATPEKLDLLLRNGGERlIQDVRLVVVDEA 127
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
 172-298 1.48e-06

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 48.88  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAV----------------SKTKPCPQVLIMAHNRPLLDQLCDEM 235
Cdd:cd18051    46 PVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIyeqgpgeslpsesgyyGRRKQYPLALVLAPTRELASQIYDEA 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1975448569 236 EKlctslnnqvtcaFADRSD-RG----GGNYVNTT--------QIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:cd18051   126 RK------------FAYRSRvRPcvvyGGADIGQQmrdlergcHLLVATPGRLVDMLERGKIGLDYCKYLVLDEAD 189
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
 172-298 2.11e-06

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 48.85  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVS-----KTKPCPQVLIMAHNRPLLDQLCDEMEKLCTSLNNQV 246
Cdd:cd18050    87 PIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINhqpylERGDGPICLVLAPTRELAQQVQQVADDYGKSSRLKS 166

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 247 TCAFADRS--------DRGggnyvntTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:cd18050   167 TCIYGGAPkgpqirdlERG-------VEICIATPGRLIDFLEAGKTNLRRCTYLVLDEAD 219
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
 164-362 4.92e-06

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 48.27  E-value: 4.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 164 EQGQFTVRPIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPCPQ------VLIMAHNRPLLDQLCDEMEK 237
Cdd:PRK10590   18 EQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKgrrpvrALILTPTRELAAQIGENVRD 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 238 LCTSLNNQVTCAFADRSD-------RGGgnyvntTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQK--SDGR 308
Cdd:PRK10590   98 YSKYLNIRSLVVFGGVSInpqmmklRGG------VDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRMLDMGfiHDIR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1975448569 309 tdgtdqiisqiiQRIERQRRRPQILFFSATIGDDALDPDDRALRNMIEHCVGRR 362
Cdd:PRK10590  172 ------------RVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARR 213
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 172-298 1.36e-05

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 46.83  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKTKPC-------PQVLIMAHNRPLLDQLCDEMEKLC--TSL 242
Cdd:PRK01297  112 PIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPkerymgePRALIIAPTRELVVQIAKDAAALTkyTGL 191

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1975448569 243 NNQVTCAFADRSDRGGGNYVNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVD 298
Cdd:PRK01297  192 NVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEAD 247
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 173-298 9.55e-05

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 43.34  E-value: 9.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 173 IQAATLPVSLAGHNLVATAETGSGKTMCFatvALAAVSK-TKPCPQV--------LIMAHNRPLLDQLCDEMEKLCTSLN 243
Cdd:cd17949    17 IQKLAIPVLLQGRDVLVRSQTGSGKTLAY---LLPIIQRlLSLEPRVdrsdgtlaLVLVPTRELALQIYEVLEKLLKPFH 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1975448569 244 NQVTCAFAdrsdrGGGNY----------VNttqIVIATAGQLNFMLKKGT-IPTKDLKLVIADEVD 298
Cdd:cd17949    94 WIVPGYLI-----GGEKRksekarlrkgVN---ILIATPGRLLDHLKNTQsFDVSNLRWLVLDEAD 151
DEXHc_RLR cd18036
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ...
 168-297 1.06e-04

DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350794 [Multi-domain]  Cd Length: 204  Bit Score: 42.85  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 168 FTVRPIQAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKtKPCP----QVLIMAHNRPLLDQLCDEMEKLCTSLN 243
Cdd:cd18036     1 LELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEK-RRSAgekgRVVVLVNKVPLVEQQLEKFFKYFRKGY 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1975448569 244 NQVTCAFADRSDRGGGNYVNTTQIVIATAGQLNFMLKKGTIPTK----DLKLVIADEV 297
Cdd:cd18036    80 KVTGLSGDSSHKVSFGQIVKASDVIICTPQILINNLLSGREEERvylsDFSLLIFDEC 137
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
164-297 4.17e-04

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 42.19  E-value: 4.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 164 EQGQFTVRPIQAATLPVSL-AGHNLVATAETGSGKTMcfatVA-LAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLCTS 241
Cdd:COG1204    17 ERGIEELYPPQAEALEAGLlEGKNLVVSAPTASGKTL----IAeLAILKALLNGGKALYIVPLRALASEKYREFKRDFEE 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1975448569 242 LNNQVTCAFADRSDRGGgnYVNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADEV 297
Cdd:COG1204    93 LGIKVGVSTGDYDSDDE--WLGRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEA 146
PRK00254 PRK00254
ski2-like helicase; Provisional
 164-341 1.07e-03

ski2-like helicase; Provisional


Pssm-ID: 234702 [Multi-domain]  Cd Length: 720  Bit Score: 40.96  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 164 EQGQFTVRPIQAATLPVS-LAGHNLVATAETGSGKTMcFATVALAAVSKTKPCPQVLIMAhnrplLDQLCDEM------- 235
Cdd:PRK00254   18 ERGIEELYPPQAEALKSGvLEGKNLVLAIPTASGKTL-VAEIVMVNKLLREGGKAVYLVP-----LKALAEEKyrefkdw 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 236 EKLctSLNNQVTCAFADRSDRGGGNYvnttQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSqKSDGRTdgtdqi 315
Cdd:PRK00254   92 EKL--GLRVAMTTGDYDSTDEWLGKY----DIIIATAEKFDSLLRHGSSWIKDVKLVVADEIHLIGS-YDRGAT------ 158

                         170       180
                  ....*....|....*....|....*.
gi 1975448569 316 isqIIQRIERQRRRPQILFFSATIGD 341
Cdd:PRK00254  159 ---LEMILTHMLGRAQILGLSATVGN 181
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 193-297 1.17e-03

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 38.83  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 193 TGSGKTMcfatVALAAVSKTKPCPqVLIMAHNRPLLDQLCDEMEKLctslnnqvtcaFADRSDR--GGGN--YVNTTQIV 268
Cdd:cd17926    27 TGSGKTL----TALALIAYLKELR-TLIVVPTDALLDQWKERFEDF-----------LGDSSIGliGGGKkkDFDDANVV 90

                          90       100
                  ....*....|....*....|....*....
gi 1975448569 269 IATAGQLNFMLKKGTIPTKDLKLVIADEV 297
Cdd:cd17926    91 VATYQSLSNLAEEEKDLFDQFGLLIVDEA 119
ResIII pfam04851
Type III restriction enzyme, res subunit;
185-297 1.23e-03

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 39.19  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 185 HNLVATAeTGSGKTMCFATVAlAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKLctSLNNQVTCAFadrsdRGGGNY--- 261
Cdd:pfam04851  25 RGLIVMA-TGSGKTLTAAKLI-ARLFKKGPIKKVLFLVPRKDLLEQALEEFKKF--LPNYVEIGEI-----ISGDKKdes 95

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1975448569 262 VNTTQIVIATAGQLNFMLKKGTIPTKDLK--LVIADEV 297
Cdd:pfam04851  96 VDDNKIVVTTIQSLYKALELASLELLPDFfdVIIIDEA 133
DEXHc_RE_I_III_res cd18032
DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model ...
 186-297 1.50e-03

DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model includes both type I and type III restriction enzymes. Both are hetero-oligomeric proteins. Type I REs are encoded by three closely linked genes: a specificity subunit (HsdS or S) for recognizing a DNA sequence, a methylation subunit (HsdM or M) for methylating the recognized target bases, and a restriction subunit (HsdR or R) for the translocation and random cleavage of non-methylated DNA. They show diverse catalytic activities, including methyltransferase (MTase), ATP hydrolase (ATPase), DNA translocation and restriction activities. These enzymes cut at a site that differs, and is a random distance (at least 1000 bp) away, from their recognition site. Cleavage at these random sites follows a process of DNA translocation, which shows that these enzymes are also molecular motors. The recognition site is asymmetrical and is composed of two specific portions: one containing 3-4 nucleotides, and another containing 4-5 nucleotides, separated by a non-specific spacer of about 6-8 nucleotides. Type III enzymes are composed of two subunits, Res and Mod. The Mod subunit recognizes the DNA sequence specific for the system and is a modification methyltransferase; as such, it is functionally equivalent to the M and S subunits of type I restriction endonucleases. Res is required for restriction, although it has no enzymatic activity on its own. Type III enzymes recognize short 5-6 bp-long asymmetric DNA sequences and cleave 25-27 bp downstream to leave short, single-stranded 5' protrusions. They require the presence of two inversely oriented unmethylated recognition sites for restriction to occur. These enzymes methylate only one strand of the DNA, at the N-6 position of adenosyl residues, so newly replicated DNA will have only one strand methylated, which is sufficient to protect against restriction. Both type I and type III REs are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350790 [Multi-domain]  Cd Length: 163  Bit Score: 39.08  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 186 NLVATAeTGSGKTMCFATVAlAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKlctsLNNQVTCAFADRSDRGGGNYvntt 265
Cdd:cd18032    23 ALLVMA-TGTGKTYTAAFLI-KRLLEANRKKRILFLAHREELLEQAERSFKE----VLPDGSFGNLKGGKKKPDDA---- 92

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1975448569 266 QIVIATAGQLNfMLKKGTIPTKD-LKLVIADEV 297
Cdd:cd18032    93 RVVFATVQTLN-KRKRLEKFPPDyFDLIIIDEA 124
DEXHc_RecG cd17918
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ...
 186-296 1.63e-03

DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350676 [Multi-domain]  Cd Length: 180  Bit Score: 38.94  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 186 NLVATAETGSGKTMCFATVALAAVSKTKpcpQVLIMAHNRPLLDQLCDEMEKLCTSLNNQVTCAFADRSDRGGGNyvntt 265
Cdd:cd17918    38 DRLLSGDVGSGKTLVALGAALLAYKNGK---QVAILVPTEILAHQHYEEARKFLPFINVELVTGGTKAQILSGIS----- 109

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1975448569 266 qIVIATAGQLNFMLKKgtiptKDLKLVIADE 296
Cdd:cd17918   110 -LLVGTHALLHLDVKF-----KNLDLVIVDE 134
DEXHc_RIG-I cd17927
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ...
 168-296 1.86e-03

DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350685 [Multi-domain]  Cd Length: 201  Bit Score: 39.34  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 168 FTVRPIQAATLPVSLAGHNLVATAETGSGKTmcFATVALAA-VSKTKPCPQ---VLIMAHNRPLLDQLCDEMEKLCTSLN 243
Cdd:cd17927     1 FKPRNYQLELAQPALKGKNTIICLPTGSGKT--FVAVLICEhHLKKFPAGRkgkVVFLANKVPLVEQQKEVFRKHFERPG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1975448569 244 NQVTCAFADRSDR-GGGNYVNTTQIVIATAGQLNFMLKKGTIPT-KDLKLVIADE 296
Cdd:cd17927    79 YKVTGLSGDTSENvSVEQIVESSDVIIVTPQILVNDLKSGTIVSlSDFSLLVFDE 133
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
 174-249 1.87e-03

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 40.20  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 174 QAATLPVSLAGHNLVATAETGSGKTMCFATVALAAVSKtKPCPQVLIMAhnrPL--L--DQLcDEMEKLCTSLNNQVTCA 249
Cdd:COG1205    61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLE-DPGATALYLY---PTkaLarDQL-RRLRELAEALGLGVRVA 135
DEXHc_archSki2 cd18028
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ...
 172-340 3.20e-03

DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350786 [Multi-domain]  Cd Length: 177  Bit Score: 38.08  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 172 PIQAATLPVSLA-GHNLVATAETGSGKTMcfatVA-LAAVSKtkpcpqvlIMAHNR-----PLLDQLCDEMEKLCTSLNN 244
Cdd:cd18028     4 PPQAEAVRAGLLkGENLLISIPTASGKTL----IAeMAMVNT--------LLEGGKalylvPLRALASEKYEEFKKLEEI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 245 QVTCAFA----DRSDRGGGNYvnttQIVIATAGQLNFMLKKGTIPTKDLKLVIADEVDDIFSQKSDGRTDGTdqiisqiI 320
Cdd:cd18028    72 GLKVGIStgdyDEDDEWLGDY----DIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTLESI-------V 140

                         170       180
                  ....*....|....*....|
gi 1975448569 321 QRIERQRRRPQILFFSATIG 340
Cdd:cd18028   141 ARLRRLNPNTQIIGLSATIG 160
DEXDc_FANCM cd18033
DEAH-box helicase domain of FANCM; Fanconi anemia group M (FANCM) protein is a DNA-dependent ...
 185-296 4.82e-03

DEAH-box helicase domain of FANCM; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, it binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA), and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, it efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, it strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA. FANCM is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350791 [Multi-domain]  Cd Length: 182  Bit Score: 37.69  E-value: 4.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1975448569 185 HNLVATAETGSGKTMcFATVALAAVSKTKPCPQVLIMAHNRPLLDQLCDEMEKL-------CTSLNNQVtcAFADRSDrg 257
Cdd:cd18033    17 QNTLVALPTGLGKTF-IAAVVMLNYYRWFPKGKIVFMAPTKPLVSQQIEACYKItgipssqTAELTGSV--PPTKRAE-- 91

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1975448569 258 ggnYVNTTQIVIATAGQLNFMLKKGTIPTKDLKLVIADE 296
Cdd:cd18033    92 ---LWASKRVFFLTPQTLENDLKEGDCDPKSIVCLVIDE 127
DEXHc_UvrB cd17916
DEXH-box helicase domain of excinuclease ABC subunit B; Excinuclease ABC subunit B (or UvrB) ...
 193-238 7.80e-03

DEXH-box helicase domain of excinuclease ABC subunit B; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II) and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA, but its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a member of the DEAD-like helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350674 [Multi-domain]  Cd Length: 299  Bit Score: 37.96  E-value: 7.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1975448569 193 TGSGKTMCFATVaLAAVSKtkpcPqVLIMAHNRPLLDQLCDEMEKL 238
Cdd:cd17916    37 TGSGKTFTIANV-IAQVNK----P-TLVIAHNKTLAAQLYSEFKEF 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH