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Conserved domains on  [gi|40641372|emb|CAE51232|]
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adenylate kinase, partial [Actinobacillus pleuropneumoniae]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11478412)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

CATH:  3.40.50.300
EC:  2.7.4.-
Gene Ontology:  GO:0050145|GO:0016310|GO:0046872
PubMed:  2841070
SCOP:  3002021

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-151 3.24e-100

adenylate kinase; Reviewed


:

Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 286.28  E-value: 3.24e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADAL----KDSGVKIDLVLEF 76
Cdd:PRK00279  34 MLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKELGIKLDAVIEI 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40641372   77 DVADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYYTA 151
Cdd:PRK00279 114 DVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKRLEVYHKQTAPLIDYYKK 188
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-151 3.24e-100

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 286.28  E-value: 3.24e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADAL----KDSGVKIDLVLEF 76
Cdd:PRK00279  34 MLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKELGIKLDAVIEI 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40641372   77 DVADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYYTA 151
Cdd:PRK00279 114 DVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKRLEVYHKQTAPLIDYYKK 188
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-149 3.67e-94

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 270.85  E-value: 3.67e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372   1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADAL----KDSGVKIDLVLEF 76
Cdd:COG0563  34 MLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIEL 113

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40641372  77 DVADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:COG0563 114 DVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRADDNEETVRKRLEVYHEQTAPLIDYY 186
ADK pfam00406
Adenylate kinase;
1-150 1.79e-87

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 253.00  E-value: 1.79e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372     1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADALKD---SGVKIDLVLEFD 77
Cdd:pfam00406  30 LLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEALEElleRGIKLDYVIEFD 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40641372    78 VADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYYT 150
Cdd:pfam00406 110 VPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNEETVKKRLETYHKQTKPLIDYYK 182
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-149 2.34e-73

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 218.26  E-value: 2.34e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372     1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQ-PDCANGFLLDGFPRTIPQADALKDSG-VKIDLVLEFDV 78
Cdd:TIGR01351  33 LLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQnDDNENGFILDGFPRTLSQAEALDALLeEPIDAVIELDV 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40641372    79 ADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:TIGR01351 113 PDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDTEEVVKKRLEVYKEQTEPLIDYY 183
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-149 1.09e-68

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 205.93  E-value: 1.09e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372   1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADALKDS---GVKIDLVLEFD 77
Cdd:cd01428  33 LLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELldeGIKPDKVIELD 112

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40641372  78 VADEVIVERMSGRRVHQPSGRTYHVvynppkveGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:cd01428 113 VPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSDDNEETIKKRLEVYKEQTAPLIDYY 176
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-151 3.24e-100

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 286.28  E-value: 3.24e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADAL----KDSGVKIDLVLEF 76
Cdd:PRK00279  34 MLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKELGIKLDAVIEI 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40641372   77 DVADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYYTA 151
Cdd:PRK00279 114 DVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKRLEVYHKQTAPLIDYYKK 188
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-149 3.67e-94

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 270.85  E-value: 3.67e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372   1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADAL----KDSGVKIDLVLEF 76
Cdd:COG0563  34 MLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIEL 113

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40641372  77 DVADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:COG0563 114 DVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRADDNEETVRKRLEVYHEQTAPLIDYY 186
ADK pfam00406
Adenylate kinase;
1-150 1.79e-87

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 253.00  E-value: 1.79e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372     1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADALKD---SGVKIDLVLEFD 77
Cdd:pfam00406  30 LLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEALEElleRGIKLDYVIEFD 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40641372    78 VADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYYT 150
Cdd:pfam00406 110 VPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNEETVKKRLETYHKQTKPLIDYYK 182
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-149 2.34e-73

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 218.26  E-value: 2.34e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372     1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQ-PDCANGFLLDGFPRTIPQADALKDSG-VKIDLVLEFDV 78
Cdd:TIGR01351  33 LLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQnDDNENGFILDGFPRTLSQAEALDALLeEPIDAVIELDV 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40641372    79 ADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:TIGR01351 113 PDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDTEEVVKKRLEVYKEQTEPLIDYY 183
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-149 1.09e-68

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 205.93  E-value: 1.09e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372   1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADALKDS---GVKIDLVLEFD 77
Cdd:cd01428  33 LLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELldeGIKPDKVIELD 112

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40641372  78 VADEVIVERMSGRRVHQPSGRTYHVvynppkveGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:cd01428 113 VPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSDDNEETIKKRLEVYKEQTAPLIDYY 176
PLN02674 PLN02674
adenylate kinase
 1-150 8.73e-53

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 167.37  E-value: 8.73e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQA----DALKDSGVKIDLVLEF 76
Cdd:PLN02674  65 MLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKGFILDGFPRTVVQAqkldEMLAKQGAKIDKVLNF 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40641372   77 DVADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYYT 150
Cdd:PLN02674 145 AIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLIQRKDDTAAVLKSRLEAFHKQTEPVIDYYA 218
adk PRK02496
adenylate kinase; Provisional
 1-149 9.05e-39

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 129.48  E-value: 9.05e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADALKDSGVKI----DLVLEF 76
Cdd:PRK02496  35 ILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLDELLQEIgqsgERVVNL 114

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40641372   77 DVADEVIVERMSGRRvhqpsgrtyhvvynppkvegkddvtgedliiRQDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:PRK02496 115 DVPDDVVVERLLARG-------------------------------RKDDTEEVIRRRLEVYREQTAPLIDYY 156
PLN02842 PLN02842
nucleotide kinase
 1-150 2.08e-37

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 133.45  E-value: 2.08e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPD-CANGFLLDGFPRTIPQADALKDSGVKIDLVLEFDVA 79
Cdd:PLN02842  31 LLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDaKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVP 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40641372   80 DEVIVERMSGRRVHQPSGRTYHVVYNPPkvegKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYYT 150
Cdd:PLN02842 111 DEILIDRCVGRRLDPVTGKIYHIKNFPP----ESEEIKARLITRPDDTEEKVKARLQIYKKNAEAILSTYS 177
PRK13808 PRK13808
adenylate kinase; Provisional
 1-150 5.67e-36

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 126.54  E-value: 5.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADA----LKDSGVKIDLVLEF 76
Cdd:PRK13808  34 MLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAANGFILDGFPRTVPQAEAldalLKDKQLKLDAVVEL 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40641372   77 DVADEVIVERMSgRRVHQPSGRtyhvvynppkvegkddvtGEDliIRQDDKPETVLERLAIYHKQTKPLIAYYT 150
Cdd:PRK13808 114 RVNEGALLARVE-TRVAEMRAR------------------GEE--VRADDTPEVLAKRLASYRAQTEPLVHYYS 166
PRK14532 PRK14532
adenylate kinase; Provisional
 1-149 6.77e-36

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 122.24  E-value: 6.77e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADA----LKDSGVKIDLVLEF 76
Cdd:PRK14532  34 MLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAGGAIFDGFPRTVAQAEAldkmLASRGQKIDVVIRL 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40641372   77 DVADEVIVERMSGRRVHQpsGRTyhvvynppkvegkddvtgedliirqDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:PRK14532 114 KVDDEALIERIVKRFEEQ--GRP-------------------------DDNPEVFVTRLDAYNAQTAPLLPYY 159
PRK14528 PRK14528
adenylate kinase; Provisional
 1-151 4.76e-35

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 120.12  E-value: 4.76e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADA----LKDSGVKIDLVLEF 76
Cdd:PRK14528  35 ILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQADAldalLKNEGKSIDKAINL 114

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40641372   77 DVADEVIVERMSGRRVhqpsgrtyhvvynppkVEGkddvtgedliiRQDDKPETVLERLAIYHKQTKPLIAYYTA 151
Cdd:PRK14528 115 EVPDGELLKRLLGRAE----------------IEG-----------RADDNEATIKNRLDNYNKKTLPLLDFYAA 162
PRK14530 PRK14530
adenylate kinase; Provisional
 17-149 7.15e-35

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 120.66  E-value: 7.15e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372   17 KALMDEGKLVPDELTVALVKDRIAQpdcANGFLLDGFPRTIPQADALKDSgVKIDLVLEFDVADEVIVERMSGRRVHQPS 96
Cdd:PRK14530  57 GEYMDAGELVPDAVVNEIVEEALSD---ADGFVLDGYPRNLEQAEYLESI-TDLDVVLYLDVSEEELVDRLTGRRVCPDC 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 40641372   97 GRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:PRK14530 133 GANYHVEFNQPEEEGVCDECGGELIQRDDDTEETVRERLDVFEENTEPVIEHY 185
PRK14526 PRK14526
adenylate kinase; Provisional
 1-150 1.18e-33

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 117.26  E-value: 1.18e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADALkDSGVKIDLVLEFDVAD 80
Cdd:PRK14526  34 LFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDNFILDGFPRNINQAKAL-DKFLPNIKIINFLIDE 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372   81 EVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIAYYT 150
Cdd:PRK14526 113 ELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDDKEESLKTRLQEYKLQTKPLIEFYS 182
PLN02459 PLN02459
probable adenylate kinase
 3-151 1.88e-29

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 107.63  E-value: 1.88e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    3 RAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRI--AQPDCANGFLLDGFPRTIPQADALKDSgVKIDLVLEFDVAD 80
Cdd:PLN02459  65 REEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLeaGEEEGESGFILDGFPRTVRQAEILEGV-TDIDLVVNLKLRE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372   81 EVIVERMSGRRVHQPSGRTYHV-------------VYNPPKVEGKDDVTgeDLIIRQDDKPETVLERLAIYHKQTKPLIA 147
Cdd:PLN02459 144 EVLVEKCLGRRICSECGKNFNVadidlkgedgrpgIVMPPLLPPPECAS--KLITRADDTEEVVKARLRVYKEESQPVED 221


                 ....
gi 40641372  148 YYTA 151
Cdd:PLN02459 222 FYRK 225
PRK14529 PRK14529
adenylate kinase; Provisional
 1-149 2.00e-27

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 101.72  E-value: 2.00e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDcANGFLLDGFPRTIPQA----DALKDSGVKIDLVLEF 76
Cdd:PRK14529  34 IFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDG-KNGWLLDGFPRNKVQAeklwEALQKEGMKLDYVIEI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372   77 DVADEVIVERMSGRRV-----HQPSgrtyHVVYNPPKVEGKD-DVTGEDLIIRQDDKPETVL-ERLAIYHK-QTKPLIAY 148
Cdd:PRK14529 113 LLPREVAKNRIMGRRLckndnNHPN----NIFIDAIKPDGDVcRVCGGELSTRADDQDEEAInKRHDIYYDtETGTLAAA 188


                 .
gi 40641372  149 Y 149
Cdd:PRK14529 189 Y 189
PRK14527 PRK14527
adenylate kinase; Provisional
 1-151 1.02e-26

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 99.09  E-value: 1.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDcANGFLLDGFPRTIPQADA----LKDSGVKIDLVLEF 76
Cdd:PRK14527  40 ILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGME-PVRVIFDGFPRTLAQAEAldrlLEELGARLLAVVLL 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40641372   77 DVADEVIVERMSGRRVHQpsgrtyhvvynppkvegkddvtgedliIRQDDKPETVLERLAIYHKQTKPLIAYYTA 151
Cdd:PRK14527 119 EVPDEELIRRIVERARQE---------------------------GRSDDNEETVRRRQQVYREQTQPLVDYYEA 166
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1-149 2.56e-25

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 96.41  E-value: 2.56e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQP--DCANGFLLDGFPRTIPQADALKDSgVKIDLVLEFDV 78
Cdd:PTZ00088  40 ILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVtdDCFKGFILDGFPRNLKQCKELGKI-TNIDLFVNIYL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372   79 ADEVIVERMSGRRVHQPSGRTYHVV------YN-PPKVEGKDDVT---GEDLIIRQDDKPETVLERLAIYHKQTKPLIAY 148
Cdd:PTZ00088 119 PRNILIKKLLGRRICNTCNRNFNIAhirsdpYDmPPILPPADCEGckgNPKLQKRSDDTEEIVAHRLNTYESTNSPIIQF 198


                 .
gi 40641372  149 Y 149
Cdd:PTZ00088 199 F 199
PRK14531 PRK14531
adenylate kinase; Provisional
 1-149 6.47e-24

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 91.41  E-value: 6.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIaQPDCANGFLLDGFPRTIPQADALK----DSGVKIDLVLEF 76
Cdd:PRK14531  36 LLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL-KALNSGGWLLDGFPRTVAQAEALEplleELKQPIEAVVLL 114

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40641372   77 DVADEVIVERMSGRRvhqpsgrtyhvvynppkvegkddvtgedliiRQDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:PRK14531 115 ELDDAVLIERLLARG-------------------------------RADDNEAVIRNRLEVYREKTAPLIDHY 156
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 1-149 1.37e-22

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 88.20  E-value: 1.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372     1 MFRAAIK-EGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADA---LKDSGVKIDLVLEF 76
Cdd:TIGR01359  33 LLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSKKFLIDGFPRNEENLEAwekLMDNKVNFKFVLFF 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40641372    77 DVADEVIVERMSGRrvHQPSGRTyhvvynppkvegkddvtgedliirqDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:TIGR01359 113 DCPEETMIKRLLKR--GQTSGRV-------------------------DDNIETLKKRFRTYNEETLPIIEHF 158
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 1-149 1.67e-20

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 82.94  E-value: 1.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372     1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRI-AQPDCANGFLLDGFPRTIPQADALKDSGVKIDLVLEFDVA 79
Cdd:TIGR01360  37 LLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMvAALGTSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCS 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    80 DEVIVERMSGRRvhQPSGRTyhvvynppkvegkddvtgedliirqDDKPETVLERLAIYHKQTKPLIAYY 149
Cdd:TIGR01360 117 EDTMVKRLLKRA--ETSGRV-------------------------DDNEKTIKKRLETYYKATEPVIAYY 159
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 90-125 1.10e-17

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 71.34  E-value: 1.10e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 40641372    90 RRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQD 125
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
AAA_17 pfam13207
AAA domain;
1-91 1.94e-14

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 65.72  E-value: 1.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372     1 MFRAAIKEGTelGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANGFLLDGFPRTIPQADALKD------SGVKIDLVL 74
Cdd:pfam13207  29 LLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAII 106

                          90
                  ....*....|....*..
gi 40641372    75 EFDVADEVIVERMSGRR 91
Cdd:pfam13207 107 LLEADPEEILERRLKDR 123
PLN02200 PLN02200
adenylate kinase family protein
 1-150 5.56e-12

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 61.06  E-value: 5.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40641372    1 MFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDcANGFLLDGFPRTIPQADALKDS-GVKIDLVLEFDVA 79
Cdd:PLN02200  77 LLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSD-NNKFLIDGFPRTEENRIAFERIiGAEPNVVLFFDCP 155

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40641372   80 DEVIVERMSGRRvhqpsgrtyhvvynppkvEGkddvtgedliiRQDDKPETVLERLAIYHKQTKPLIAYYT 150
Cdd:PLN02200 156 EEEMVKRVLNRN------------------QG-----------RVDDNIDTIKKRLKVFNALNLPVIDYYS 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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