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Conserved domains on  [gi|1984976480|emb|CAE5363489|]
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unnamed protein product, partial [Corethron pennatum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 79-209 1.16e-23

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


:

Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 97.70  E-value: 1.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  79 TPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAA--DGGGTVLVVAPVRELALQLAAVAGSlLGEGADASVRLA 156
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDklDNGPQALVLAPTRELAEQIYEELKK-LGKGLGLKVASL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1984976480 157 ARGVPPPA-ADELAGASVLVGTPSELRTLVEggaAAEFVAALSGIVLDEVDVLL 209
Cdd:pfam00270  80 LGGDSRKEqLEKLKGPDILVGTPGRLLDLLQ---ERKLLKNLKLLVLDEAHRLL 130
HELICc smart00490
helicase superfamily c-terminal domain;
496-537 7.61e-07

helicase superfamily c-terminal domain;


:

Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 46.82  E-value: 7.61e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1984976480  496 RFLVAPEEAARGLHLDDVDAVFLVGRPASAASYLHLAGRVGR 537
Cdd:smart00490  39 KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
 
Name Accession Description Interval E-value
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 79-209 1.16e-23

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 97.70  E-value: 1.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  79 TPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAA--DGGGTVLVVAPVRELALQLAAVAGSlLGEGADASVRLA 156
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDklDNGPQALVLAPTRELAEQIYEELKK-LGKGLGLKVASL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1984976480 157 ARGVPPPA-ADELAGASVLVGTPSELRTLVEggaAAEFVAALSGIVLDEVDVLL 209
Cdd:pfam00270  80 LGGDSRKEqLEKLKGPDILVGTPGRLLDLLQ---ERKLLKNLKLLVLDEAHRLL 130
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 70-209 1.67e-23

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 97.90  E-value: 1.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  70 LSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALS-----AAADGGGT-VLVVAPVRELALQLAAVAgS 143
Cdd:cd00268     5 LKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEkllpePKKKGRGPqALVLAPTRELAMQIAEVA-R 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1984976480 144 LLGEGADASVRLAARGVPP-PAADELA-GASVLVGTPSELRTLVEGGaaAEFVAALSGIVLDEVDVLL 209
Cdd:cd00268    84 KLGKGTGLKVAAIYGGAPIkKQIEALKkGPDIVVGTPGRLLDLIERG--KLDLSNVKYLVLDEADRML 149
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
70-209 2.33e-18

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 87.51  E-value: 2.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  70 LSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALS---AAADGGGTVLVVAPVRELALQLAAVAgSLLG 146
Cdd:COG0513    17 LAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQrldPSRPRAPQALILAPTRELALQVAEEL-RKLA 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1984976480 147 EGADASVRLAARGVPP-PAADELA-GASVLVGTPSELRTLVEGGAaaefvAALSGI---VLDEVDVLL 209
Cdd:COG0513    96 KYLGLRVATVYGGVSIgRQIRALKrGVDIVVATPGRLLDLIERGA-----LDLSGVetlVLDEADRML 158
DEXDc smart00487
DEAD-like helicases superfamily;
78-210 5.95e-16

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 76.38  E-value: 5.95e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480   78 PTPIQSASAAVASAGE-DVLLVAPTGSGKSLAYLLPALSAAADG-GGTVLVVAPVRELALQLAAVAGSLLGEGADASVRL 155
Cdd:smart00487   9 LRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEALKRGkGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGL 88

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1984976480  156 AARGVPPPAADELAG--ASVLVGTPSELRTLVEGGaaAEFVAALSGIVLDEVDVLLP 210
Cdd:smart00487  89 YGGDSKREQLRKLESgkTDILVTTPGRLLDLLEND--KLSLSNVDLVILDEAHRLLD 143
PTZ00110 PTZ00110
helicase; Provisional
 53-209 3.09e-11

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 65.95  E-value: 3.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  53 PPPTRTLSEL-FPAFApsLSALRLA---SPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPA---LSAAA----DGG 121
Cdd:PTZ00110  126 PKPVVSFEYTsFPDYI--LKSLKNAgftEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAivhINAQPllryGDG 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 122 GTVLVVAPVRELALQLAAVAGSLlgeGADASVR--LAARGVP--PPAADELAGASVLVGTPSELRTLVEGGaaaefVAAL 197
Cdd:PTZ00110  204 PIVLVLAPTRELAEQIREQCNKF---GASSKIRntVAYGGVPkrGQIYALRRGVEILIACPGRLIDFLESN-----VTNL 275

                         170
                  ....*....|....*
gi 1984976480 198 SGI---VLDEVDVLL 209
Cdd:PTZ00110  276 RRVtylVLDEADRML 290
HELICc smart00490
helicase superfamily c-terminal domain;
496-537 7.61e-07

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 46.82  E-value: 7.61e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1984976480  496 RFLVAPEEAARGLHLDDVDAVFLVGRPASAASYLHLAGRVGR 537
Cdd:smart00490  39 KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 496-537 2.49e-06

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 46.43  E-value: 2.49e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1984976480 496 RFLVAPEEAARGLHLDDVDAVFLVGRPASAASYLHLAGRVGR 537
Cdd:pfam00271  66 DVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGR 107
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 496-537 3.14e-06

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 46.73  E-value: 3.14e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1984976480 496 RFLVAPEEAARGLHLDDVDAVFLVGRPASAASYLHLAGRVGR 537
Cdd:cd18787    79 RVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGR 120
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
 497-537 3.78e-04

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 43.04  E-value: 3.78e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1984976480 497 FLVAPEEAARGLHLDDVDAVFLVGRPASAASYLHLAGRVGR 537
Cdd:PRK04837  308 ILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGR 348
 
Name Accession Description Interval E-value
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 79-209 1.16e-23

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 97.70  E-value: 1.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  79 TPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAA--DGGGTVLVVAPVRELALQLAAVAGSlLGEGADASVRLA 156
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDklDNGPQALVLAPTRELAEQIYEELKK-LGKGLGLKVASL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1984976480 157 ARGVPPPA-ADELAGASVLVGTPSELRTLVEggaAAEFVAALSGIVLDEVDVLL 209
Cdd:pfam00270  80 LGGDSRKEqLEKLKGPDILVGTPGRLLDLLQ---ERKLLKNLKLLVLDEAHRLL 130
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 70-209 1.67e-23

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 97.90  E-value: 1.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  70 LSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALS-----AAADGGGT-VLVVAPVRELALQLAAVAgS 143
Cdd:cd00268     5 LKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEkllpePKKKGRGPqALVLAPTRELAMQIAEVA-R 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1984976480 144 LLGEGADASVRLAARGVPP-PAADELA-GASVLVGTPSELRTLVEGGaaAEFVAALSGIVLDEVDVLL 209
Cdd:cd00268    84 KLGKGTGLKVAAIYGGAPIkKQIEALKkGPDIVVGTPGRLLDLIERG--KLDLSNVKYLVLDEADRML 149
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 92-210 1.14e-21

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 91.31  E-value: 1.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAAADGGGTVLVVAPVRELALQLAAVAGSLLGEGADASVRLAARGVPPPAADELAGA 171
Cdd:cd00046     1 GENVLITAPTGSGKTLAALLAALLLLLKKGKKVLVLVPTKALALQTAERLRELFGPGIRVAVLVGGSSAEEREKNKLGDA 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1984976480 172 SVLVGTPSELRTLVEgGAAAEFVAALSGIVLDEVDVLLP 210
Cdd:cd00046    81 DIIIATPDMLLNLLL-REDRLFLKDLKLIIVDEAHALLI 118
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
70-209 2.33e-18

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 87.51  E-value: 2.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  70 LSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALS---AAADGGGTVLVVAPVRELALQLAAVAgSLLG 146
Cdd:COG0513    17 LAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQrldPSRPRAPQALILAPTRELALQVAEEL-RKLA 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1984976480 147 EGADASVRLAARGVPP-PAADELA-GASVLVGTPSELRTLVEGGAaaefvAALSGI---VLDEVDVLL 209
Cdd:COG0513    96 KYLGLRVATVYGGVSIgRQIRALKrGVDIVVATPGRLLDLIERGA-----LDLSGVetlVLDEADRML 158
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
 78-211 1.08e-17

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 81.48  E-value: 1.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSA----AADGGGTVLVVAPVRELALQLaAVAGSLLGEGADASV 153
Cdd:cd17957    13 PTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKlgkpRKKKGLRALILAPTRELASQI-YRELLKLSKGTGLRI 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1984976480 154 RLAARGVPPPAADELA---GASVLVGTPSELRTLVEGGAaaefvAALSGI---VLDEVDVLLPP 211
Cdd:cd17957    92 VLLSKSLEAKAKDGPKsitKYDILVSTPLRLVFLLKQGP-----IDLSSVeylVLDEADKLFEP 150
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
 64-209 1.88e-17

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 81.09  E-value: 1.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  64 PAFAPSLSALRLASPTPIQSAS-AAVASAGEDVLLVAPTGSGKSLAYLLPALSAAADG-----GGTV--LVVAPVRELAL 135
Cdd:cd17964     3 PSLLKALTRMGFETMTPVQQKTlKPILSTGDDVLARAKTGTGKTLAFLLPAIQSLLNTkpagrRSGVsaLIISPTRELAL 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1984976480 136 QLAAVAGSLLGEGADASVRLAARGVPPPAAD---ELAGASVLVGTPSELRTLVEGGAAAEFVAALSGIVLDEVDVLL 209
Cdd:cd17964    83 QIAAEAKKLLQGLRKLRVQSAVGGTSRRAELnrlRRGRPDILVATPGRLIDHLENPGVAKAFTDLDYLVLDEADRLL 159
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
 70-209 1.03e-16

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 78.77  E-value: 1.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  70 LSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALS-------AAADGGGTVLVVAPVRELALQLAAVAG 142
Cdd:cd17960     5 VAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEillkrkaNLKKGQVGALIISPTRELATQIYEVLQ 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1984976480 143 SLL-GEGADASVRLAARGVPPPAADEL---AGASVLVGTPSELRTLVEGGAAAEFVAALSGIVLDEVDVLL 209
Cdd:cd17960    85 SFLeHHLPKLKCQLLIGGTNVEEDVKKfkrNGPNILVGTPGRLEELLSRKADKVKVKSLEVLVLDEADRLL 155
DEXDc smart00487
DEAD-like helicases superfamily;
78-210 5.95e-16

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 76.38  E-value: 5.95e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480   78 PTPIQSASAAVASAGE-DVLLVAPTGSGKSLAYLLPALSAAADG-GGTVLVVAPVRELALQLAAVAGSLLGEGADASVRL 155
Cdd:smart00487   9 LRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEALKRGkGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGL 88

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1984976480  156 AARGVPPPAADELAG--ASVLVGTPSELRTLVEGGaaAEFVAALSGIVLDEVDVLLP 210
Cdd:smart00487  89 YGGDSKREQLRKLESgkTDILVTTPGRLLDLLEND--KLSLSNVDLVILDEAHRLLD 143
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
 70-209 3.61e-15

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 74.21  E-value: 3.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  70 LSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPAL-----SAAADGGGTVLVVAPVRELALQLAAVaGSL 144
Cdd:cd17947     5 LSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILerllyRPKKKAATRVLVLVPTRELAMQCFSV-LQQ 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1984976480 145 LGEGADASVRLAARGVPPPAAD-EL-AGASVLVGTPSELRTLVEGGAAAEfVAALSGIVLDEVDVLL 209
Cdd:cd17947    84 LAQFTDITFALAVGGLSLKAQEaALrARPDIVIATPGRLIDHLRNSPSFD-LDSIEILVLDEADRML 149
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
 69-209 2.10e-14

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 72.23  E-value: 2.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  69 SLSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPAL--------SAAADGGGTVLVVAPVRELALQLAAV 140
Cdd:cd17961     8 AIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIqkilkakaESGEEQGTRALILVPTRELAQQVSKV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 141 AGSL------------LGEGADASVRLAARGVPPpaadelagaSVLVGTPSELRTLVEGGaAAEFVAALSGIVLDEVDVL 208
Cdd:cd17961    88 LEQLtaycrkdvrvvnLSASSSDSVQRALLAEKP---------DIVVSTPARLLSHLESG-SLLLLSTLKYLVIDEADLV 157


                  .
gi 1984976480 209 L 209
Cdd:cd17961   158 L 158
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
 69-209 3.33e-14

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 71.25  E-value: 3.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  69 SLSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAA-------DGGGTVLVVAPVRELALQLAAVA 141
Cdd:cd17966     4 ELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINaqpplerGDGPIVLVLAPTRELAQQIQQEA 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1984976480 142 GSLlgeGADASVRLAA--RGVP--PPAADELAGASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:cd17966    84 NKF---GGSSRLRNTCvyGGAPkgPQIRDLRRGVEICIATPGRLIDFLDQGKTN--LRRVTYLVLDEADRML 150
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
 78-209 4.61e-14

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 70.96  E-value: 4.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPAL--------SAAADGGGTVLVVAPVRELALQLAAVAGSLLGEGA 149
Cdd:cd17958    13 PSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFihldlqpiPREQRNGPGVLVLTPTRELALQIEAECSKYSYKGL 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1984976480 150 DaSVRLAARGVPPPAADELA-GASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:cd17958    93 K-SVCVYGGGNRNEQIEDLSkGVDIIIATPGRLNDLQMNNVIN--LKSITYLVLDEADRML 150
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 70-209 1.04e-13

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 70.01  E-value: 1.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  70 LSALRLA---SPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSA-------AADGGGtVLVVAPVRELALQLAA 139
Cdd:cd17941     2 LKGLKEAgfiKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKlyrerwtPEDGLG-ALIISPTRELAMQIFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 140 V-----------AGSLLGeGADASVRLaargvpppaaDELAGASVLVGTPSelRTLVEGGAAAEFVAA-LSGIVLDEVDV 207
Cdd:cd17941    81 VlrkvgkyhsfsAGLIIG-GKDVKEEK----------ERINRMNILVCTPG--RLLQHMDETPGFDTSnLQMLVLDEADR 147


                  ..
gi 1984976480 208 LL 209
Cdd:cd17941   148 IL 149
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
 53-209 1.46e-13

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 70.77  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  53 PPPTRTLSE--LFPAFAPSLSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAADGGGT------- 123
Cdd:cd18052    39 PPAILTFEEanLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTassfsev 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 124 ----VLVVAPVRELALQ--LAAVAGSLlgegaDASVR--LAARGVPPP--AADELAGASVLVGTPSELRTLVEGGAAAef 193
Cdd:cd18052   119 qepqALIVAPTRELANQifLEARKFSY-----GTCIRpvVVYGGVSVGhqIRQIEKGCHILVATPGRLLDFIGRGKIS-- 191

                         170
                  ....*....|....*.
gi 1984976480 194 VAALSGIVLDEVDVLL 209
Cdd:cd18052   192 LSKLKYLILDEADRML 207
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
 78-209 1.84e-13

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 70.09  E-value: 1.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPAL-----SAAADGGGT----VLVVAPVRELALQLAAVAGSlLGEG 148
Cdd:cd17948    13 PTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIqrllrYKLLAEGPFnaprGLVITPSRELAEQIGSVAQS-LTEG 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1984976480 149 ADASVR--LAARGVPPPAADELAGASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:cd17948    92 LGLKVKviTGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYS--LEQLRHLVLDEADTLL 152
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
 53-209 1.90e-12

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 66.96  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  53 PPPTRTLSEL-FPAFAPSLSALR-LASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPAL------SAAADGGGTV 124
Cdd:cd18049    20 PKPVLNFYEAnFPANVMDVIARQnFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIvhinhqPFLERGDGPI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 125 -LVVAPVRELALQLAAVAGSlLGEGADASVRLAARGVP--PPAADELAGASVLVGTPSELRTLVEGGAAAefVAALSGIV 201
Cdd:cd18049   100 cLVLAPTRELAQQVQQVAAE-YGRACRLKSTCIYGGAPkgPQIRDLERGVEICIATPGRLIDFLEAGKTN--LRRCTYLV 176


                  ....*...
gi 1984976480 202 LDEVDVLL 209
Cdd:cd18049   177 LDEADRML 184
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
 69-209 2.74e-12

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 65.71  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  69 SLSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPAL-SAAADGGGT-VLVVAPVRELALQLA---AVAGS 143
Cdd:cd17955    13 QCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILqRLSEDPYGIfALVLTPTRELAYQIAeqfRALGA 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1984976480 144 LLGegadASVRLAARGVPPPA-ADELAG-ASVLVGTPSELRTLVEGGAAAEFVAALSG-IVLDEVDVLL 209
Cdd:cd17955    93 PLG----LRCCVIVGGMDMVKqALELSKrPHIVVATPGRLADHLRSSDDTTKVLSRVKfLVLDEADRLL 157
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
 74-209 4.94e-12

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 66.57  E-value: 4.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  74 RLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPAL------SAAADGGGTV-LVVAPVRELALQLAAVAGSlLG 146
Cdd:cd18050    81 NFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIvhinhqPYLERGDGPIcLVLAPTRELAQQVQQVADD-YG 159

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1984976480 147 EGADASVRLAARGVP--PPAADELAGASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:cd18050   160 KSSRLKSTCIYGGAPkgPQIRDLERGVEICIATPGRLIDFLEAGKTN--LRRCTYLVLDEADRML 222
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 71-209 5.53e-12

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 65.30  E-value: 5.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  71 SALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAA--------DGGGTVLVVAPVRELALQLAAVAG 142
Cdd:cd17949     7 SKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLsleprvdrSDGTLALVLVPTRELALQIYEVLE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 143 SLL-------------GEGAD---ASVRlaargvpppaadelAGASVLVGTPSelRTLVEGGAAAEF-VAALSGIVLDEV 205
Cdd:cd17949    87 KLLkpfhwivpgyligGEKRKsekARLR--------------KGVNILIATPG--RLLDHLKNTQSFdVSNLRWLVLDEA 150


                  ....
gi 1984976480 206 DVLL 209
Cdd:cd17949   151 DRLL 154
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
 78-209 9.98e-12

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 64.24  E-value: 9.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSA--AADGGGTVLVVAPVRELALQLAAVAGSlLGEGADASVrL 155
Cdd:cd17940    22 PSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKidPKKDVIQALILVPTRELALQTSQVCKE-LGKHMGVKV-M 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1984976480 156 AARGVPPPAADEL---AGASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:cd17940   100 VTTGGTSLRDDIMrlyQTVHVLVGTPGRILDLAKKGVAD--LSHCKTLVLDEADKLL 154
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 78-209 2.01e-11

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 63.05  E-value: 2.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPAL-SAAADGGGT-VLVVAPVRELALQLAAVAGSL--LGEGADASV 153
Cdd:cd17943    13 PSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALeSLDLERRHPqVLILAPTREIAVQIHDVFKKIgkKLEGLKCEV 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1984976480 154 RLAARGVpppAAD--ELAGASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:cd17943    93 FIGGTPV---KEDkkKLKGCHIAVGTPGRIKQLIELGALN--VSHVRLFVLDEADKLM 145
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
 78-209 2.53e-11

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 63.27  E-value: 2.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSA-------AADGGG-----TVLVVAPVRELALQLAAVA---- 141
Cdd:cd17967    23 PTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKlledgppSVGRGRrkaypSALILAPTRELAIQIYEEArkfs 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1984976480 142 -GSLLgegadaSVRLAARGVPP--PAADELAGASVLVGTPSELRTLVEGGaaaefVAALSGI---VLDEVDVLL 209
Cdd:cd17967   103 yRSGV------RSVVVYGGADVvhQQLQLLRGCDILVATPGRLVDFIERG-----RISLSSIkflVLDEADRML 165
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
 69-209 2.86e-11

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 63.41  E-value: 2.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  69 SLSALRLASPTPIQSAS-AAVASAGEDVLLVAPTGSGKSLAYLLPAL-----------SAAADGGGTVLVVAPVRELALQ 136
Cdd:cd17946     4 ALADLGFSEPTPIQALAlPAAIRDGKDVIGAAETGSGKTLAFGIPILerllsqkssngVGGKQKPLRALILTPTRELAVQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 137 ----LAAVA-------GSLLGeGAdASV---RLAARgvpppaadelaGASVLVGTPSELRTLVEggAAAEFVAALSGI-- 200
Cdd:cd17946    84 vkdhLKAIAkytnikiASIVG-GL-AVQkqeRLLKK-----------RPEIVVATPGRLWELIQ--EGNEHLANLKSLrf 148

                         170
                  ....*....|
gi 1984976480 201 -VLDEVDVLL 209
Cdd:cd17946   149 lVLDEADRML 158
PTZ00110 PTZ00110
helicase; Provisional
 53-209 3.09e-11

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 65.95  E-value: 3.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  53 PPPTRTLSEL-FPAFApsLSALRLA---SPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPA---LSAAA----DGG 121
Cdd:PTZ00110  126 PKPVVSFEYTsFPDYI--LKSLKNAgftEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAivhINAQPllryGDG 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 122 GTVLVVAPVRELALQLAAVAGSLlgeGADASVR--LAARGVP--PPAADELAGASVLVGTPSELRTLVEGGaaaefVAAL 197
Cdd:PTZ00110  204 PIVLVLAPTRELAEQIREQCNKF---GASSKIRntVAYGGVPkrGQIYALRRGVEILIACPGRLIDFLESN-----VTNL 275

                         170
                  ....*....|....*
gi 1984976480 198 SGI---VLDEVDVLL 209
Cdd:PTZ00110  276 RRVtylVLDEADRML 290
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 61-209 4.11e-11

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 64.96  E-value: 4.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  61 ELFPAFAPSLSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAAD------GGGTVLVVAPVRELA 134
Cdd:PRK11192    7 ELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDfprrksGPPRILILTPTRELA 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1984976480 135 LQLAAVAgSLLGEGADASVRLAARGVP-PPAADELAG-ASVLVGTPSELRTLVEGGAA-AEFVAALsgiVLDEVDVLL 209
Cdd:PRK11192   87 MQVADQA-RELAKHTHLDIATITGGVAyMNHAEVFSEnQDIVVATPGRLLQYIKEENFdCRAVETL---ILDEADRML 160
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
 78-209 1.32e-10

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 60.64  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAADGGGT--VLVVAPVRELALQLAAVAGSLLGEGADASVRL 155
Cdd:cd17962    13 PTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNpsALILTPTRELAVQIEDQAKELMKGLPPMKTAL 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1984976480 156 AARGVP-PPAADELA-GASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:cd17962    93 LVGGLPlPPQLYRLQqGVKVIIATPGRLLDILKQSSVE--LDNIKIVVVDEADTML 146
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
 70-206 1.59e-10

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 60.51  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  70 LSALR---LASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAADG-------GGTVLVVAPVRELALQLAA 139
Cdd:cd17952     2 LNAIRkqeYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQrelekgeGPIAVIVAPTRELAQQIYL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1984976480 140 VAgSLLGEGADASVRLAARGVPP-PAADEL-AGASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVD 206
Cdd:cd17952    82 EA-KKFGKAYNLRVVAVYGGGSKwEQAKALqEGAEIVVATPGRLIDMVKKKATN--LQRVTYLVLDEAD 147
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
 73-241 1.85e-10

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 60.80  E-value: 1.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  73 LRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSA----------AADGGGTVLVVAPVRELALQLAAVA- 141
Cdd:cd17945     8 LGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYisrlppldeeTKDDGPYALILAPTRELAQQIEEETq 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 142 --GSLLGEGAdASVrlaargVPPPAADELA-----GASVLVGTPSEL------RTLVeggaaaefVAALSGIVLDEVDVL 208
Cdd:cd17945    88 kfAKPLGIRV-VSI------VGGHSIEEQAfslrnGCEILIATPGRLldclerRLLV--------LNQCTYVVLDEADRM 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1984976480 209 L-----PPPTK---AVRTSLDGHKNRDNKNLTADERNKAKQ 241
Cdd:cd17945   153 IdmgfePQVTKildAMPVSNKKPDTEEAEKLAASGKHRYRQ 193
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
 70-137 2.61e-10

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 60.47  E-value: 2.61e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1984976480  70 LSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALS------AAADGGGTV-LVVAPVRELALQL 137
Cdd:cd17953    27 IKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRhikdqrPVKPGEGPIgLIMAPTRELALQI 101
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
 92-205 2.85e-10

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 62.93  E-value: 2.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAAA-DGGGTVLVVAPVRELAL-QLAAVAG--SLLGEGADASV---------RLAAR 158
Cdd:COG1205    71 GKNVVIATPTASGKSLAYLLPVLEALLeDPGATALYLYPTKALARdQLRRLRElaEALGLGVRVATydgdtppeeRRWIR 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1984976480 159 gvpppaadelAGASVLVGTPSEL-RTLVEGGAA-AEFVAALSGIVLDEV 205
Cdd:COG1205   151 ----------EHPDIVLTNPDMLhYGLLPHHTRwARFFRNLRYVVIDEA 189
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 79-205 2.97e-10

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 59.58  E-value: 2.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  79 TPIQSAS-AAVASAGEDVLLVAPTGSGKSLAYLLPALSAAADGGGTVLVVAPVRELALQLAAVAGSLLGEGADASVRLAa 157
Cdd:cd17921     3 NPIQREAlRALYLSGDSVLVSAPTSSGKTLIAELAILRALATSGGKAVYIAPTRALVNQKEADLRERFGPLGKNVGLLT- 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1984976480 158 rGVPPPAADELAGASVLVGTPSELRTLVEGGaAAEFVAALSGIVLDEV 205
Cdd:cd17921    82 -GDPSVNKLLLAEADILVATPEKLDLLLRNG-GERLIQDVRLVVVDEA 127
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
 79-209 4.46e-10

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 59.30  E-value: 4.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  79 TPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPA------LSAAADGGGTVLVVAPVRELALQLAAVAGSLLGEGADAS 152
Cdd:cd17942    14 TEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAiellykLKFKPRNGTGVIIISPTRELALQIYGVAKELLKYHSQTF 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1984976480 153 VRLAARGVPPPAADELA-GASVLVGTPSelRTLVEGGAAAEFVAA-LSGIVLDEVDVLL 209
Cdd:cd17942    94 GIVIGGANRKAEAEKLGkGVNILVATPG--RLLDHLQNTKGFLYKnLQCLIIDEADRIL 150
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
 53-209 7.29e-10

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 61.34  E-value: 7.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  53 PPPTRTLSE--LFPAFAPSLSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAA---------DGG 121
Cdd:PLN00206  117 PPPILSFSScgLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCtirsghpseQRN 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 122 GTVLVVAPVRELALQLAAVAgSLLGEGADASVRLAARGVPPPAadEL----AGASVLVGTPSELRTLVEGGAAAefVAAL 197
Cdd:PLN00206  197 PLAMVLTPTRELCVQVEDQA-KVLGKGLPFKTALVVGGDAMPQ--QLyriqQGVELIVGTPGRLIDLLSKHDIE--LDNV 271

                         170
                  ....*....|..
gi 1984976480 198 SGIVLDEVDVLL 209
Cdd:PLN00206  272 SVLVLDEVDCML 283
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
 78-209 8.26e-10

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 58.49  E-value: 8.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAAdgggtVLVVAPVRELALQLAAVAGSLLGEGADASVR--L 155
Cdd:cd17938    22 PTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV-----ALILEPSRELAEQTYNCIENFKKYLDNPKLRvaL 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1984976480 156 AARGVPPPAADEL--AGASVLVGTPSELRTLVEGGaaaefVAALSGI---VLDEVDVLL 209
Cdd:cd17938    97 LIGGVKAREQLKRleSGVDIVVGTPGRLEDLIKTG-----KLDLSSVrffVLDEADRLL 150
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
 78-209 1.16e-09

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 58.10  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSA--AADGGGTVLVVAPVRELALQLAAVAGSLlgeGADASVRL 155
Cdd:cd17954    23 PTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQAllENPQRFFALVLAPTRELAQQISEQFEAL---GSSIGLKS 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1984976480 156 A--ARGVPPPA-ADELA-GASVLVGTPSELRTLVEGGAAAEFVaALSGIVLDEVDVLL 209
Cdd:cd17954   100 AvlVGGMDMMAqAIALAkKPHVIVATPGRLVDHLENTKGFSLK-SLKFLVMDEADRLL 156
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
 67-209 1.33e-09

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 60.63  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  67 APSLSALR---LASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALS--AAADGGGTVLVVAPVRELALQLAAVA 141
Cdd:PRK11634   15 APILEALNdlgYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHnlDPELKAPQILVLAPTRELAVQVAEAM 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 142 GSLL-------------GEGADASVRlAARGvpppaadelaGASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVL 208
Cdd:PRK11634   95 TDFSkhmrgvnvvalygGQRYDVQLR-ALRQ----------GPQIVVGTPGRLLDHLKRGTLD--LSKLSGLVLDEADEM 161


                  .
gi 1984976480 209 L 209
Cdd:PRK11634  162 L 162
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
 78-208 8.53e-09

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 55.77  E-value: 8.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPAL----SAAADGGGTVLVVAPVRELALQLAAVaGSLLGEGADASV 153
Cdd:cd17959    24 PTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIeklkAHSPTVGARALILSPTRELALQTLKV-TKELGKFTDLRT 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1984976480 154 RLAARGVpppAADELAGA-----SVLVGTPSE-LRTLVEGG---AAAEFVaalsgiVLDEVDVL 208
Cdd:cd17959   103 ALLVGGD---SLEEQFEAlasnpDIIIATPGRlLHLLVEMNlklSSVEYV------VFDEADRL 157
DEXHc_RecQ1 cd18015
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ...
 56-129 1.52e-08

DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350773 [Multi-domain]  Cd Length: 209  Bit Score: 55.06  E-value: 1.52e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1984976480  56 TRTLSELFpafapSLSALRlasptPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSaaadGGGTVLVVAP 129
Cdd:cd18015     7 KDTLKNVF-----KLEKFR-----PLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALC----SDGFTLVVSP 66
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
 69-186 2.06e-08

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 54.65  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  69 SLSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAAD---------GGGTV-LVVAPVRELALQLA 138
Cdd:cd17951     4 GLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEqekklpfikGEGPYgLIVCPSRELARQTH 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1984976480 139 AVAGS---LLGEGADASVR--LAARGVPPPAADELA--GASVLVGTPSELRTLVE 186
Cdd:cd17951    84 EVIEYyckALQEGGYPQLRclLCIGGMSVKEQLEVIrkGVHIVVATPGRLMDMLN 138
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
 94-157 3.86e-08

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 54.18  E-value: 3.86e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1984976480  94 DVLLVAPTGSGKSLAYLLPALSAAADGGGT---VLVVAPVRELALQLAAVAgSLLGEGADASVRLAA 157
Cdd:cd17956    38 DLCVSAPTGSGKTLAYVLPIVQALSKRVVPrlrALIVVPTKELVQQVYKVF-ESLCKGTGLKVVSLS 103
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
 80-209 5.19e-08

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 53.31  E-value: 5.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  80 PIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAADGGGT--------VLVVAPVRELALQLAAvagsllgEGADA 151
Cdd:cd17944    15 PIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPrkrgrapkVLVLAPTRELANQVTK-------DFKDI 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1984976480 152 SVRLAAR----GVP-PPAADEL-AGASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:cd17944    88 TRKLSVAcfygGTPyQQQIFAIrNGIDILVGTPGRIKDHLQNGRLD--LTKLKHVVLDEVDQML 149
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
 74-209 8.48e-08

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 53.51  E-value: 8.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  74 RLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALS----------AAADGGG--------TVLVVAPVRELAL 135
Cdd:cd18051    40 RYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSqiyeqgpgesLPSESGYygrrkqypLALVLAPTRELAS 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 136 QLaavagsllgegADASVRLAARGVPPPA-----AD------ELA-GASVLVGTPSELRTLVE-GGAAAEFVAALsgiVL 202
Cdd:cd18051   120 QI-----------YDEARKFAYRSRVRPCvvyggADigqqmrDLErGCHLLVATPGRLVDMLErGKIGLDYCKYL---VL 185


                  ....*..
gi 1984976480 203 DEVDVLL 209
Cdd:cd18051   186 DEADRML 192
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 102-209 1.31e-07

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 52.19  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 102 GSGKSLAYLLPALSA--AADGGGTVLVVAPVRELALQLAAVAgSLLGEGADASVRLAARGVPPPaADELAGASVLVGTPS 179
Cdd:cd17963    43 GTGKTAAFVLAMLSRvdPTLKSPQALCLAPTRELARQIGEVV-EKMGKFTGVKVALAVPGNDVP-RGKKITAQIVIGTPG 120

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1984976480 180 ELRTLVeggaaAEFVAALSGI---VLDEVDVLL 209
Cdd:cd17963   121 TVLDWL-----KKRQLDLKKIkilVLDEADVML 148
DEXHc_Hrq1-like cd17923
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ...
 92-204 2.59e-07

DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350681 [Multi-domain]  Cd Length: 182  Bit Score: 51.05  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAAA-DGGGTVLVVAPVRELAL-QLAAVAGSLLGEGADASVRLAARGVPPPAADELA 169
Cdd:cd17923    15 GRSVVVTTGTASGKSLCYQLPILEALLrDPGSRALYLYPTKALAQdQLRSLRELLEQLGLGIRVATYDGDTPREERRAII 94

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1984976480 170 --GASVLVGTPSELRTLV--EGGAAAEFVAALSGIVLDE 204
Cdd:cd17923    95 rnPPRILLTNPDMLHYALlpHHDRWARFLRNLRYVVLDE 133
DEXHc_LHR-like cd17922
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ...
 92-209 2.61e-07

DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350680 [Multi-domain]  Cd Length: 166  Bit Score: 50.66  E-value: 2.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAAADGGGT---VLVVAPVRELAL-QLAAVAGSLLGEGAD-----------ASVRLA 156
Cdd:cd17922     1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEKgvqVLYISPLKALINdQERRLEEPLDEIDLEipvavrhgdtsQSEKAK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1984976480 157 ARGVPPpaadelagaSVLVGTPSELRTLVEGGAAAEFVAALSGIVLDEVDVLL 209
Cdd:cd17922    81 QLKNPP---------GILITTPESLELLLVNKKLRELFAGLRYVVVDEIHALL 124
DEXHc_RecQ cd17920
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ...
 92-129 3.65e-07

DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.


Pssm-ID: 350678 [Multi-domain]  Cd Length: 200  Bit Score: 50.61  E-value: 3.65e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAaadgGGTVLVVAP 129
Cdd:cd17920    27 GRDVLVVMPTGGGKSLCYQLPALLL----DGVTLVVSP 60
HELICc smart00490
helicase superfamily c-terminal domain;
496-537 7.61e-07

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 46.82  E-value: 7.61e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1984976480  496 RFLVAPEEAARGLHLDDVDAVFLVGRPASAASYLHLAGRVGR 537
Cdd:smart00490  39 KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
DEXHc_RecQ4-like cd18018
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ...
 92-129 1.14e-06

DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.


Pssm-ID: 350776 [Multi-domain]  Cd Length: 201  Bit Score: 49.18  E-value: 1.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAAADGGGTVLVVAP 129
Cdd:cd18018    27 GRSTLVVLPTGAGKSLCYQLPALLLRRRGPGLTLVVSP 64
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 496-537 2.49e-06

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 46.43  E-value: 2.49e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1984976480 496 RFLVAPEEAARGLHLDDVDAVFLVGRPASAASYLHLAGRVGR 537
Cdd:pfam00271  66 DVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGR 107
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 496-537 3.14e-06

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 46.73  E-value: 3.14e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1984976480 496 RFLVAPEEAARGLHLDDVDAVFLVGRPASAASYLHLAGRVGR 537
Cdd:cd18787    79 RVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGR 120
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 62-209 3.22e-06

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 49.80  E-value: 3.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  62 LFPAFAPSLSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSA--AADGGGTVLVVAPVRELALQlaa 139
Cdd:PRK11776   11 LPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKldVKRFRVQALVLCPTRELADQ--- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480 140 VAGSLlgegadasvRLAAR------------GVP-PPAADELA-GASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEV 205
Cdd:PRK11776   88 VAKEI---------RRLARfipnikvltlcgGVPmGPQIDSLEhGAHIIVGTPGRILDHLRKGTLD--LDALNTLVLDEA 156


                  ....
gi 1984976480 206 DVLL 209
Cdd:PRK11776  157 DRML 160
Lhr COG1201
Lhr-like helicase [Replication, recombination and repair];
74-134 4.27e-06

Lhr-like helicase [Replication, recombination and repair];


Pssm-ID: 440814 [Multi-domain]  Cd Length: 850  Bit Score: 49.72  E-value: 4.27e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1984976480  74 RLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAADGGGT--------VLVVAPVRELA 134
Cdd:COG1201    21 RFGAPTPPQREAWPAIAAGESTLLIAPTGSGKTLAAFLPALDELARRPRPgelpdglrVLYISPLKALA 89
DinG COG1199
Rad3-related DNA helicase DinG [Replication, recombination and repair];
92-126 4.54e-06

Rad3-related DNA helicase DinG [Replication, recombination and repair];


Pssm-ID: 440812 [Multi-domain]  Cd Length: 629  Bit Score: 49.54  E-value: 4.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAAADGGGTVLV 126
Cdd:COG1199    33 GRHLLIEAGTGTGKTLAYLVPALLAARETGKKVVI 67
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
 78-209 4.60e-06

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 47.32  E-value: 4.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALS--AAADGGGTVLVVAPVRELALQLAAVAGSlLGEGADASVRL 155
Cdd:cd17939    20 PSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQriDTTVRETQALVLAPTRELAQQIQKVVKA-LGDYMGVKVHA 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1984976480 156 AARGVPPPAADEL--AGASVLVGTPSELRTLVEGGA-AAEFvaaLSGIVLDEVDVLL 209
Cdd:cd17939    99 CIGGTSVREDRRKlqYGPHIVVGTPGRVFDMLQRRSlRTDK---IKMFVLDEADEML 152
DEXHc_RecG cd17918
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ...
 94-177 2.49e-05

DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350676 [Multi-domain]  Cd Length: 180  Bit Score: 45.10  E-value: 2.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  94 DVLLVAPTGSGKSLAYLLPALsAAADGGGTVLVVAPVRELALQLAAVAGSLLgegADASVRLAARGVpppAADELAGASV 173
Cdd:cd17918    38 DRLLSGDVGSGKTLVALGAAL-LAYKNGKQVAILVPTEILAHQHYEEARKFL---PFINVELVTGGT---KAQILSGISL 110


                  ....
gi 1984976480 174 LVGT 177
Cdd:cd17918   111 LVGT 114
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
92-205 2.58e-05

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 46.94  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  92 GEDVLLVAPTGSGKSlaYLLPALSAAADGGGTVLVVAPVRELALQLAAVAGSLLGEgadasvRLAARGVPPPAADelaga 171
Cdd:COG1061   100 GGRGLVVAPTGTGKT--VLALALAAELLRGKRVLVLVPRRELLEQWAEELRRFLGD------PLAGGGKKDSDAP----- 166

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1984976480 172 sVLVGTpseLRTLVEGGAAAEFVAALSGIVLDEV 205
Cdd:COG1061   167 -ITVAT---YQSLARRAHLDELGDRFGLVIIDEA 196
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
92-205 3.41e-05

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 46.43  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAAADgGGTVLVVAPVRELALQlaaVAGSLLGEGADASVRLAAR-GVPPPAADELAG 170
Cdd:COG1204    38 GKNLVVSAPTASGKTLIAELAILKALLN-GGKALYIVPLRALASE---KYREFKRDFEELGIKVGVStGDYDSDDEWLGR 113

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1984976480 171 ASVLVGTP----SELRTlveggaAAEFVAALSGIVLDEV 205
Cdd:COG1204   114 YDILVATPekldSLLRN------GPSWLRDVDLVVVDEA 146
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
 78-209 4.65e-05

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 44.74  E-value: 4.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSA--AADGGGTVLVVAPVRELALQLAAVAgSLLGEGADASVRL 155
Cdd:cd18046    22 PSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQidTSLKATQALVLAPTRELAQQIQKVV-MALGDYMGIKCHA 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1984976480 156 AARG--VPPPAADELAGASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:cd18046   101 CIGGtsVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLR--TDYIKMFVLDEADEML 154
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
92-129 4.68e-05

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 45.90  E-value: 4.68e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSaaadGGGTVLVVAP 129
Cdd:COG0514    32 GRDALVVMPTGGGKSLCYQLPALL----LPGLTLVVSP 65
DEXHc_RecQ2_BLM cd18016
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ...
 92-153 1.27e-04

DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.


Pssm-ID: 350774 [Multi-domain]  Cd Length: 208  Bit Score: 43.28  E-value: 1.27e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAAadggGTVLVVAPVRELAL-------QLAAVAGSLLGEGADASV 153
Cdd:cd18016    32 GEDCFVLMPTGGGKSLCYQLPACVSP----GVTVVISPLRSLIVdqvqkltSLDIPATYLTGDKTDAEA 96
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
 93-209 1.71e-04

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 43.09  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  93 EDVLLVAPTGSGKSLAYLLPALSA--AADGGGTVLVVAPVRELALQLAAVAGSLLGEGADASVRLAARGVPPPAADELAg 170
Cdd:cd18048    58 QNLIAQSQSGTGKTAAFVLAMLSRvdALKLYPQCLCLSPTFELALQTGKVVEEMGKFCVGIQVIYAIRGNRPGKGTDIE- 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1984976480 171 ASVLVGTPS-------ELRTLVeggaaaefVAALSGIVLDEVDVLL 209
Cdd:cd18048   137 AQIVIGTPGtvldwcfKLRLID--------VTNISVFVLDEADVMI 174
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
 78-209 2.02e-04

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 42.84  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAADG--GGTVLVVAPVRELALQLAAVAGSlLGEGADASVRL 155
Cdd:cd18045    22 PSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQvrETQALILSPTRELAVQIQKVLLA-LGDYMNVQCHA 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1984976480 156 AARGvpPPAADELA----GASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:cd18045   101 CIGG--TSVGDDIRkldyGQHIVSGTPGRVFDMIRRRSLR--TRHIKMLVLDEADEML 154
DEXHc_archSki2 cd18028
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ...
 92-134 2.46e-04

DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350786 [Multi-domain]  Cd Length: 177  Bit Score: 41.94  E-value: 2.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAAADgGGTVLVVAPVRELA 134
Cdd:cd18028    17 GENLLISIPTASGKTLIAEMAMVNTLLE-GGKALYLVPLRALA 58
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
 497-537 3.78e-04

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 43.04  E-value: 3.78e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1984976480 497 FLVAPEEAARGLHLDDVDAVFLVGRPASAASYLHLAGRVGR 537
Cdd:PRK04837  308 ILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGR 348
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 498-537 4.20e-04

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 43.01  E-value: 4.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1984976480 498 LVAPEEAARGLHLDDVDAVFLVGRPASAASYLHLAGRVGR 537
Cdd:PRK11192  299 LVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGR 338
DEXHc_cas3 cd17930
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ...
 92-156 4.25e-04

DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350688 [Multi-domain]  Cd Length: 186  Bit Score: 41.51  E-value: 4.25e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAAADGGGTVLVVA-PVRELALQLAAVAGSLLG-EGADASVRLA 156
Cdd:cd17930     1 PGLVILEAPTGSGKTEAALLWALKLAARGGKRRIIYAlPTRATINQMYERIREILGrLDDEDKVLLL 67
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 497-537 6.00e-04

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 38.45  E-value: 6.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1984976480 497 FLVAPEEAARGLHLDDVDAVFLVGRPASAASYLHLAGRVGR 537
Cdd:cd18785    25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGR 65
Cas3 COG1203
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ...
 95-147 9.36e-04

CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 440816 [Multi-domain]  Cd Length: 535  Bit Score: 41.99  E-value: 9.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1984976480  95 VLLVAPTGSGKSLAYLLPALSAAADGGGT-VLVVAPVRELALQLAAVAGSLLGE 147
Cdd:COG1203   150 FILTAPTGGGKTEAALLFALRLAAKHGGRrIIYALPFTSIINQTYDRLRDLFGE 203
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 92-159 1.10e-03

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 40.01  E-value: 1.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAAADGGGTVLVVAP----VRELALQLAAVAGSLLGEGADASVRLAARG 159
Cdd:cd17990    17 GGQVVLEAPPGAGKTTRVPLALLAELWIAGGKIIVLEPrrvaARAAARRLATLLGEAPGETVGYRVRGESRV 88
DEXHc_Hef cd18035
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ...
 96-178 1.34e-03

DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350793 [Multi-domain]  Cd Length: 181  Bit Score: 39.81  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  96 LLVAPTGSGKSLAYLLPALSAAADGGGTVLVVAPVRELALQLAAVAGSLLgEGADASVRLAARGVPPPAADELAGASVLV 175
Cdd:cd18035    20 LIVLPTGLGKTIIAILVAADRLTKKGGKVLILAPSRPLVEQHAENLKRVL-NIPDKITSLTGEVKPEERAERWDASKIIV 98


                  ...
gi 1984976480 176 GTP 178
Cdd:cd18035    99 ATP 101
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
 96-209 1.37e-03

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 40.44  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  96 LLVAPTGSGKSLAYLLPALSA------------------AADGGGT-VLVVAPVRELALQLAAVAGSlLGEGADASVRLA 156
Cdd:cd17965    65 LLAAETGSGKTLAYLAPLLDYlkrqeqepfeeaeeeyesAKDTGRPrSVILVPTHELVEQVYSVLKK-LSHTVKLGIKTF 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1984976480 157 ARGVPPPAADEL----AGASVLVGTPSELRTLVEggAAAEFVAALSGIVLDEVDVLL 209
Cdd:cd17965   144 SSGFGPSYQRLQlafkGRIDILVTTPGKLASLAK--SRPKILSRVTHLVVDEADTLF 198
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 62-144 1.39e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 41.44  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  62 LFPAFAPSLSALRLASPTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAAAD---------GGGTVLVVAPVRE 132
Cdd:PRK01297   94 LAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQtpppkerymGEPRALIIAPTRE 173

                          90
                  ....*....|..
gi 1984976480 133 LALQLAAVAGSL 144
Cdd:PRK01297  174 LVVQIAKDAAAL 185
PLN03137 PLN03137
ATP-dependent DNA helicase; Q4-like; Provisional
 92-133 1.90e-03

ATP-dependent DNA helicase; Q4-like; Provisional


Pssm-ID: 215597 [Multi-domain]  Cd Length: 1195  Bit Score: 41.03  E-value: 1.90e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1984976480   92 GEDVLLVAPTGSGKSLAYLLPALSAAadggGTVLVVAPVREL 133
Cdd:PLN03137   475 GYDVFVLMPTGGGKSLTYQLPALICP----GITLVISPLVSL 512
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 92-133 2.65e-03

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 40.47  E-value: 2.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1984976480  92 GEDVLLVAPTGSGKSLAYLLPALSAaadgGGTVLVVAPVREL 133
Cdd:PRK11057   40 GRDCLVVMPTGGGKSLCYQIPALVL----DGLTLVVSPLISL 77
PTZ00424 PTZ00424
helicase 45; Provisional
 78-209 3.04e-03

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 40.19  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPALSAA--ADGGGTVLVVAPVRELALQLAAVAGSLlgeGADASVRL 155
Cdd:PTZ00424   51 PSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIdyDLNACQALILAPTRELAQQIQKVVLAL---GDYLKVRC 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1984976480 156 AARGVPPPAADEL----AGASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:PTZ00424  128 HACVGGTVVRDDInklkAGVHMVVGTPGRVYDMIDKRHLR--VDDLKLFILDEADEML 183
DEAD-like_helicase_N cd17912
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 96-140 5.11e-03

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


Pssm-ID: 350670 [Multi-domain]  Cd Length: 81  Bit Score: 35.96  E-value: 5.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1984976480  96 LLVAPTGSGKSLAYLLPALSAAADGGGtVLVVAPVRELALQLAAV 140
Cdd:cd17912     3 LHLGPTGSGKTLVAIQKIASAMSSGKS-VLVVTPTKLLAHEILIV 46
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
 78-209 5.63e-03

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 39.41  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1984976480  78 PTPIQSASAAVASAGEDVLLVAPTGSGKSLAYLLPAL------SAAADGGGTV--LVVAPVRELALQlaavagslLGEGA 149
Cdd:PRK10590   24 PTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLqhlitrQPHAKGRRPVraLILTPTRELAAQ--------IGENV 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1984976480 150 -DASVRLAAR------GVP--PPAADELAGASVLVGTPSELRTLVEGGAAAefVAALSGIVLDEVDVLL 209
Cdd:PRK10590   96 rDYSKYLNIRslvvfgGVSinPQMMKLRGGVDVLVATPGRLLDLEHQNAVK--LDQVEILVLDEADRML 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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