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Conserved domains on  [gi|47215800|emb|CAG02854|]
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unnamed protein product [Tetraodon nigroviridis]

Protein Classification

Clathrin_H_link and CLH domain-containing protein( domain architecture ID 12019188)

protein containing domains Clathrin_propel, Clathrin_H_link, CLH, and Clathrin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1465-1607 1.94e-41

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 149.35  E-value: 1.94e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    1465 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1544
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47215800    1545 QAHLWGELVFLYDKYEEYDNAIITMMSHPADAwkeGQFKDIVTKVANVELYYKAVHFYLEFKP 1607
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
1089-1228 2.07e-37

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 137.79  E-value: 2.07e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    1089 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYI-NRLDNYDAPDIAN 1167
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47215800    1168 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPPVWSQLAKAQLQK 1228
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
886-1021 1.29e-34

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 129.70  E-value: 1.29e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     886 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNP--ERFLRENPYYDSRVVGKYCE 963
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     964 KRDPH-LACVAYERGQCDQELIHVCNENS-LFKSLSRYLVRRKNPELWASVLLETNNYRR 1021
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
575-708 1.24e-33

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 127.01  E-value: 1.24e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     575 EPLADITQIVDVFMEYNLIQQCTSFLLDALKNNrPMEGALQTRLLEMNLVHAPQVADAILGNqMFTHYDRAHVAQLCEKA 654
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 47215800     655 GLLQRALEHYTDLYDIKRAVVHT--HLLNPEWLVNFFGS-LSVEDSLECLRAMLSAN 708
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 390-455 1.66e-31

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


:

Pssm-ID: 463995  Cd Length: 66  Bit Score: 118.08  E-value: 1.66e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47215800    390 NLAGAEELFARKFNTLFAAGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 455
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
CLH smart00299
Clathrin heavy chain repeat homology;
720-877 1.07e-29

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.83  E-value: 1.07e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     720 ASKYHEQLTTQALTQLFESFKSFEGLFYFLGSIVNF-SQDPEVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLK 798
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     799 vfasesrrlaaegldsspqEAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NSLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 877
Cdd:smart00299   81 -------------------KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1655-1752 5.21e-18

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 82.30  E-value: 5.21e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800   1655 ACVQVKQLPLVKPYLRSVQN---HNNKSVNEALNNLFIIEEDFAALRTSIDAYDNFDNISLAQGLEKHELIEFRRiaaYL 1731
Cdd:pfam00637   16 LFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKADLYEEAV---IL 92

                           90       100
                   ....*....|....*....|.
gi 47215800   1732 FKGNNRWKQSVELCKKDKLYK 1752
Cdd:pfam00637   93 YKKIGNWKEAISLLKKLGDYK 113
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 365-388 1.65e-10

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


:

Pssm-ID: 462732  Cd Length: 24  Bit Score: 57.45  E-value: 1.65e-10
                           10        20
                   ....*....|....*....|....
gi 47215800    365 EENIIPYITNVLQNPDLALRMAVR 388
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 232-268 5.06e-08

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 50.49  E-value: 5.06e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47215800    232 AAGFAQFKMEGNTEESTLFCFAVRGQAGGKLHIIEVG 268
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 330-364 2.56e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.79  E-value: 2.56e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47215800    330 NRISGETIFVTAPHEPTAGIIGVN--RKGQVLSVCVE 364
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 290-322 4.30e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 4.30e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 47215800    290 AQNDFPVAMQISSKQDVVFLITKYGYIHLYDLE 322
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 53-89 8.72e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 8.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47215800     53 GINPANIGFSTLTMESDKFICVREKVGeQAQVVIIDM 89
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 182-221 1.03e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.17  E-value: 1.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47215800    182 LAGCQIINYRTDAKQKWLLLIGISaqqNRVMGAMQLYSVD 221
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1465-1607 1.94e-41

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 149.35  E-value: 1.94e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    1465 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1544
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47215800    1545 QAHLWGELVFLYDKYEEYDNAIITMMSHPADAwkeGQFKDIVTKVANVELYYKAVHFYLEFKP 1607
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
1089-1228 2.07e-37

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 137.79  E-value: 2.07e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    1089 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYI-NRLDNYDAPDIAN 1167
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47215800    1168 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPPVWSQLAKAQLQK 1228
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
886-1021 1.29e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 129.70  E-value: 1.29e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     886 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNP--ERFLRENPYYDSRVVGKYCE 963
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     964 KRDPH-LACVAYERGQCDQELIHVCNENS-LFKSLSRYLVRRKNPELWASVLLETNNYRR 1021
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1089-1229 5.88e-34

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 128.14  E-value: 5.88e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800   1089 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYINRLDNYDAPDIAN 1167
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47215800   1168 IAISNELFEEAFAIFRKFDVNTSAVqVLIEHIGNLDRAYEFAERCNEPPVWSQLAKAQLQKG 1229
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
575-708 1.24e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 127.01  E-value: 1.24e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     575 EPLADITQIVDVFMEYNLIQQCTSFLLDALKNNrPMEGALQTRLLEMNLVHAPQVADAILGNqMFTHYDRAHVAQLCEKA 654
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 47215800     655 GLLQRALEHYTDLYDIKRAVVHT--HLLNPEWLVNFFGS-LSVEDSLECLRAMLSAN 708
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 390-455 1.66e-31

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 118.08  E-value: 1.66e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47215800    390 NLAGAEELFARKFNTLFAAGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 455
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1465-1607 1.41e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.51  E-value: 1.41e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800   1465 LHIVVHADELEELINYYQDRGYFEELITMLEAALGL-ERAHMGMFTELAILYSKF-KPQKMREHLELFWSrVNIPKVLRA 1542
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47215800   1543 AEQAHLWGELVFLYDKYEEYDNAIitMMSHPADAWKEGQfkDIVTKVANVELYYKAVHFYLEFKP 1607
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 896-1023 6.89e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.59  E-value: 6.89e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    896 DELVAEVEKRNRLKLLLPWLEARIHEG-CEEPATHNALAKIYIDSN--NNPERFLRENPYYDSRVVGKYCEKRDPH-LAC 971
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESALKEDsRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 47215800    972 VAYERGQCDQELIHVCNENSLFKSLSRYLVRRKNPELWASVLLETNNYRRPL 1023
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
720-877 1.07e-29

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.83  E-value: 1.07e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     720 ASKYHEQLTTQALTQLFESFKSFEGLFYFLGSIVNF-SQDPEVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLK 798
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     799 vfasesrrlaaegldsspqEAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NSLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 877
Cdd:smart00299   81 -------------------KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 575-712 5.29e-28

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 111.19  E-value: 5.29e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    575 EPLADITQIVDVFMEYNLIQQCTSFLLDALKNNRPMEGALQTRLLEMNLVHAP-QVADAILgnQMFTHYDRAHVAQLCEK 653
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    654 AGLLQRALEHYTDLYDIKRAV-VHTHLLNPEWLVNFFGSLSVEDSLECLRAMLSANIRQN 712
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 722-877 1.13e-23

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 98.48  E-value: 1.13e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    722 KYHEQLTTQALTQLFESFKSFEGLFYFLGSIVNFS--QDPEVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLkv 799
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC-- 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47215800    800 fasesrrlaaegldsspQEAKLTDQLPLIIVCdrFDFVHDLV-LYLYRNSLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 877
Cdd:pfam00637   81 -----------------EKADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1655-1752 5.21e-18

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 82.30  E-value: 5.21e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800   1655 ACVQVKQLPLVKPYLRSVQN---HNNKSVNEALNNLFIIEEDFAALRTSIDAYDNFDNISLAQGLEKHELIEFRRiaaYL 1731
Cdd:pfam00637   16 LFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKADLYEEAV---IL 92

                           90       100
                   ....*....|....*....|.
gi 47215800   1732 FKGNNRWKQSVELCKKDKLYK 1752
Cdd:pfam00637   93 YKKIGNWKEAISLLKKLGDYK 113
CLH smart00299
Clathrin heavy chain repeat homology;
1618-1752 3.56e-11

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 62.68  E-value: 3.56e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    1618 SPRLDHTRAVNFFSKVGllllilllllllpllscwpcacvqvkQLPLVKPYLRSVQNHNnkSVNEALNNLFIIEEDFAAL 1697
Cdd:smart00299    5 SDPIDVSEVVELFEKRN--------------------------LLEELIPYLESALKLN--SENPALQTKLIELYAKYDP 56

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 47215800    1698 RTSIDAYDNFdnislaqglekHELIEFRRIAAYLFKGNNrWKQSVELCKKDKLYK 1752
Cdd:smart00299   57 QKEIERLDNK-----------SNHYDIEKVGKLCEKAKL-YEEAVELYKKDGNFK 99
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 365-388 1.65e-10

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 57.45  E-value: 1.65e-10
                           10        20
                   ....*....|....*....|....
gi 47215800    365 EENIIPYITNVLQNPDLALRMAVR 388
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 232-268 5.06e-08

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 50.49  E-value: 5.06e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47215800    232 AAGFAQFKMEGNTEESTLFCFAVRGQAGGKLHIIEVG 268
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 330-364 2.56e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.79  E-value: 2.56e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47215800    330 NRISGETIFVTAPHEPTAGIIGVN--RKGQVLSVCVE 364
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 290-322 4.30e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 4.30e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 47215800    290 AQNDFPVAMQISSKQDVVFLITKYGYIHLYDLE 322
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 53-89 8.72e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 8.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47215800     53 GINPANIGFSTLTMESDKFICVREKVGeQAQVVIIDM 89
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1165-1259 3.17e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 3.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800 1165 IANIAISNELFEEAFAIFRKF----DVNTSAVQVLI---EHIGNLDRAYEFAERC-----NEPPVWSQLAKAQLQKGLVK 1232
Cdd:COG2956   82 LAQDYLKAGLLDRAEELLEKLleldPDDAEALRLLAeiyEQEGDWEKAIEVLERLlklgpENAHAYCELAELYLEQGDYD 161

                         90       100       110
                 ....*....|....*....|....*....|..
gi 47215800 1233 EAIDSYIKA-----DDPSAYMEVGQAAAQSGR 1259
Cdd:COG2956  162 EAIEALEKAlkldpDCARALLLLAELYLEQGD 193
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1171-1259 4.74e-04

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 44.77  E-value: 4.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800 1171 SNELFEEAFAIFR----KFDVntsAVQvliehIGNLDRAYEFAERCNEPPVWSQLAKAQLQKGLVKEAIDSYIKADDPSA 1246
Cdd:cd22947  324 SQGLKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSG 395

                         90       100
                 ....*....|....*....|....*.
gi 47215800 1247 YM-------------EVGQAAAQSGR 1259
Cdd:cd22947  396 LLllysstgdkegleELAELAEAAGK 421
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 182-221 1.03e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.17  E-value: 1.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47215800    182 LAGCQIINYRTDAKQKWLLLIGISaqqNRVMGAMQLYSVD 221
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1465-1607 1.94e-41

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 149.35  E-value: 1.94e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    1465 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1544
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47215800    1545 QAHLWGELVFLYDKYEEYDNAIITMMSHPADAwkeGQFKDIVTKVANVELYYKAVHFYLEFKP 1607
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
1089-1228 2.07e-37

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 137.79  E-value: 2.07e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    1089 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYI-NRLDNYDAPDIAN 1167
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47215800    1168 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPPVWSQLAKAQLQK 1228
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
886-1021 1.29e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 129.70  E-value: 1.29e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     886 IMVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNP--ERFLRENPYYDSRVVGKYCE 963
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     964 KRDPH-LACVAYERGQCDQELIHVCNENS-LFKSLSRYLVRRKNPELWASVLLETNNYRR 1021
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1089-1229 5.88e-34

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 128.14  E-value: 5.88e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800   1089 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYINRLDNYDAPDIAN 1167
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47215800   1168 IAISNELFEEAFAIFRKFDVNTSAVqVLIEHIGNLDRAYEFAERCNEPPVWSQLAKAQLQKG 1229
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
575-708 1.24e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 127.01  E-value: 1.24e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     575 EPLADITQIVDVFMEYNLIQQCTSFLLDALKNNrPMEGALQTRLLEMNLVHAPQVADAILGNqMFTHYDRAHVAQLCEKA 654
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 47215800     655 GLLQRALEHYTDLYDIKRAVVHT--HLLNPEWLVNFFGS-LSVEDSLECLRAMLSAN 708
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 390-455 1.66e-31

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 118.08  E-value: 1.66e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47215800    390 NLAGAEELFARKFNTLFAAGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 455
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1465-1607 1.41e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 118.51  E-value: 1.41e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800   1465 LHIVVHADELEELINYYQDRGYFEELITMLEAALGL-ERAHMGMFTELAILYSKF-KPQKMREHLELFWSrVNIPKVLRA 1542
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47215800   1543 AEQAHLWGELVFLYDKYEEYDNAIitMMSHPADAWKEGQfkDIVTKVANVELYYKAVHFYLEFKP 1607
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 896-1023 6.89e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.59  E-value: 6.89e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    896 DELVAEVEKRNRLKLLLPWLEARIHEG-CEEPATHNALAKIYIDSN--NNPERFLRENPYYDSRVVGKYCEKRDPH-LAC 971
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESALKEDsRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 47215800    972 VAYERGQCDQELIHVCNENSLFKSLSRYLVRRKNPELWASVLLETNNYRRPL 1023
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
720-877 1.07e-29

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.83  E-value: 1.07e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     720 ASKYHEQLTTQALTQLFESFKSFEGLFYFLGSIVNF-SQDPEVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLK 798
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800     799 vfasesrrlaaegldsspqEAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NSLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 877
Cdd:smart00299   81 -------------------KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 575-712 5.29e-28

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 111.19  E-value: 5.29e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    575 EPLADITQIVDVFMEYNLIQQCTSFLLDALKNNRPMEGALQTRLLEMNLVHAP-QVADAILgnQMFTHYDRAHVAQLCEK 653
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    654 AGLLQRALEHYTDLYDIKRAV-VHTHLLNPEWLVNFFGSLSVEDSLECLRAMLSANIRQN 712
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 722-877 1.13e-23

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 98.48  E-value: 1.13e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    722 KYHEQLTTQALTQLFESFKSFEGLFYFLGSIVNFS--QDPEVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLkv 799
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC-- 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47215800    800 fasesrrlaaegldsspQEAKLTDQLPLIIVCdrFDFVHDLV-LYLYRNSLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 877
Cdd:pfam00637   81 -----------------EKADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1655-1752 5.21e-18

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 82.30  E-value: 5.21e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800   1655 ACVQVKQLPLVKPYLRSVQN---HNNKSVNEALNNLFIIEEDFAALRTSIDAYDNFDNISLAQGLEKHELIEFRRiaaYL 1731
Cdd:pfam00637   16 LFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKADLYEEAV---IL 92

                           90       100
                   ....*....|....*....|.
gi 47215800   1732 FKGNNRWKQSVELCKKDKLYK 1752
Cdd:pfam00637   93 YKKIGNWKEAISLLKKLGDYK 113
CLH smart00299
Clathrin heavy chain repeat homology;
1618-1752 3.56e-11

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 62.68  E-value: 3.56e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800    1618 SPRLDHTRAVNFFSKVGllllilllllllpllscwpcacvqvkQLPLVKPYLRSVQNHNnkSVNEALNNLFIIEEDFAAL 1697
Cdd:smart00299    5 SDPIDVSEVVELFEKRN--------------------------LLEELIPYLESALKLN--SENPALQTKLIELYAKYDP 56

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 47215800    1698 RTSIDAYDNFdnislaqglekHELIEFRRIAAYLFKGNNrWKQSVELCKKDKLYK 1752
Cdd:smart00299   57 QKEIERLDNK-----------SNHYDIEKVGKLCEKAKL-YEEAVELYKKDGNFK 99
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 365-388 1.65e-10

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 57.45  E-value: 1.65e-10
                           10        20
                   ....*....|....*....|....
gi 47215800    365 EENIIPYITNVLQNPDLALRMAVR 388
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 232-268 5.06e-08

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 50.49  E-value: 5.06e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47215800    232 AAGFAQFKMEGNTEESTLFCFAVRGQAGGKLHIIEVG 268
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 330-364 2.56e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.79  E-value: 2.56e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47215800    330 NRISGETIFVTAPHEPTAGIIGVN--RKGQVLSVCVE 364
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 290-322 4.30e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 4.30e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 47215800    290 AQNDFPVAMQISSKQDVVFLITKYGYIHLYDLE 322
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 53-89 8.72e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 41.25  E-value: 8.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47215800     53 GINPANIGFSTLTMESDKFICVREKVGeQAQVVIIDM 89
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
Coatomer_WDAD pfam04053
Coatomer WD associated region; This region is composed of WD40 repeats.
 1184-1243 3.03e-04

Coatomer WD associated region; This region is composed of WD40 repeats.


Pssm-ID: 427679  Cd Length: 439  Bit Score: 45.30  E-value: 3.03e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800   1184 KFDVntsAVQvliehIGNLDRAYEFAERCNEPPVWSQLAKAQLQKGLVKEAIDSYIKADD 1243
Cdd:pfam04053  320 RFDL---ALE-----LGNLDVALEIAKELDDPAKWKRLGDAALSQGNIKLAEEAYQKAKD 371
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1165-1259 3.17e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 3.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800 1165 IANIAISNELFEEAFAIFRKF----DVNTSAVQVLI---EHIGNLDRAYEFAERC-----NEPPVWSQLAKAQLQKGLVK 1232
Cdd:COG2956   82 LAQDYLKAGLLDRAEELLEKLleldPDDAEALRLLAeiyEQEGDWEKAIEVLERLlklgpENAHAYCELAELYLEQGDYD 161

                         90       100       110
                 ....*....|....*....|....*....|..
gi 47215800 1233 EAIDSYIKA-----DDPSAYMEVGQAAAQSGR 1259
Cdd:COG2956  162 EAIEALEKAlkldpDCARALLLLAELYLEQGD 193
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1171-1259 4.74e-04

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 44.77  E-value: 4.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800 1171 SNELFEEAFAIFR----KFDVntsAVQvliehIGNLDRAYEFAERCNEPPVWSQLAKAQLQKGLVKEAIDSYIKADDPSA 1246
Cdd:cd22947  324 SQGLKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSG 395

                         90       100
                 ....*....|....*....|....*.
gi 47215800 1247 YM-------------EVGQAAAQSGR 1259
Cdd:cd22947  396 LLllysstgdkegleELAELAEAAGK 421
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 182-221 1.03e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.17  E-value: 1.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47215800    182 LAGCQIINYRTDAKQKWLLLIGISaqqNRVMGAMQLYSVD 221
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1164-1259 4.69e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.40  E-value: 4.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47215800 1164 DIANIAISNELFEEAFAIFRKF----DVNTSAVQVLIE---HIGNLDRAYEFAERC-----NEPPVWSQLAKAQLQKGLV 1231
Cdd:COG4783    9 ALAQALLLAGDYDEAEALLEKAleldPDNPEAFALLGEillQLGDLDEAIVLLHEAleldpDEPEARLNLGLALLKAGDY 88

                         90       100       110
                 ....*....|....*....|....*....|...
gi 47215800 1232 KEAIDSYIKA-----DDPSAYMEVGQAAAQSGR 1259
Cdd:COG4783   89 DEALALLEKAlkldpEHPEAYLRLARAYRALGR 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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