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Conserved domains on  [gi|55729233|emb|CAH91352|]
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hypothetical protein [Pongo abelii]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 464-560 2.27e-35

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 129.44  E-value: 2.27e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 464 LKVPGNVTAVLGQTLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQD--KGPSKASVNCDENSRLVSLTLNPVTRADEGW 541
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEgvVPGGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                        90
                ....*....|....*....
gi 55729233 542 YWCGVKQGHFYGETAAVYV 560
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-126 3.89e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 111.34  E-value: 3.89e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233  24 GPEEVNSVEGNSVSITCYYPPTsvNRHTRKYWCRQGaSGRCITLISSEGYVSNnyaGRANLTNFPENGTFVVNIAQLSRD 103
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWG-SEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....
gi 55729233 104 DSGRYKCGLGIN-IRGLSFDVSLE 126
Cdd:cd05716  77 DAGWYWCGVGDDgDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 356-457 4.77e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 111.34  E-value: 4.77e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 356 PTVVKGVAGGSVAVLCPYNPKESKSIKYWCLWegaQNGRCSLLVESQGQVKEqyeGRLSLLEEPGNGTFTVILNQLTSQD 435
Cdd:cd05716   4 PEVVTGVEGGSVTIQCPYPPKYASSRKYWCKW---GSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|..
gi 55729233 436 AGFYWCLNNGDTRWRTTVEIKI 457
Cdd:cd05716  78 AGWYWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 239-331 9.36e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 93.23  E-value: 9.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 239 KPEPQLVYEDLRGSVTFHCALGLEVANVAKFLCRESSEeNCDVVINTLGKRAPafeGRILLNPQDKDGSFSVVITGLRKE 318
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSE-GCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90
                ....*....|...
gi 55729233 319 DAGRYLCGAHSDG 331
Cdd:cd05716  77 DAGWYWCGVGDDG 89
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 134-236 2.05e-19

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 83.60  E-value: 2.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 134 LNDTKVYTVDVGRTVTINCPFKTENAPKTKSLYKQIGLSPVLVIDSTGYVNPnymGRIHLDVQGTGqLVFSVVINRLRLS 213
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDN-GVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....
gi 55729233 214 DAGQYLCQAG-YGSNSNKKNADLQ 236
Cdd:cd05716  77 DAGWYWCGVGdDGDRGLTVQVKLV 100
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 464-560 2.27e-35

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 129.44  E-value: 2.27e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 464 LKVPGNVTAVLGQTLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQD--KGPSKASVNCDENSRLVSLTLNPVTRADEGW 541
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEgvVPGGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                        90
                ....*....|....*....
gi 55729233 542 YWCGVKQGHFYGETAAVYV 560
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-126 3.89e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 111.34  E-value: 3.89e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233  24 GPEEVNSVEGNSVSITCYYPPTsvNRHTRKYWCRQGaSGRCITLISSEGYVSNnyaGRANLTNFPENGTFVVNIAQLSRD 103
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWG-SEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....
gi 55729233 104 DSGRYKCGLGIN-IRGLSFDVSLE 126
Cdd:cd05716  77 DAGWYWCGVGDDgDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 356-457 4.77e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 111.34  E-value: 4.77e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 356 PTVVKGVAGGSVAVLCPYNPKESKSIKYWCLWegaQNGRCSLLVESQGQVKEqyeGRLSLLEEPGNGTFTVILNQLTSQD 435
Cdd:cd05716   4 PEVVTGVEGGSVTIQCPYPPKYASSRKYWCKW---GSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|..
gi 55729233 436 AGFYWCLNNGDTRWRTTVEIKI 457
Cdd:cd05716  78 AGWYWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 239-331 9.36e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 93.23  E-value: 9.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 239 KPEPQLVYEDLRGSVTFHCALGLEVANVAKFLCRESSEeNCDVVINTLGKRAPafeGRILLNPQDKDGSFSVVITGLRKE 318
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSE-GCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90
                ....*....|...
gi 55729233 319 DAGRYLCGAHSDG 331
Cdd:cd05716  77 DAGWYWCGVGDDG 89
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 134-236 2.05e-19

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 83.60  E-value: 2.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 134 LNDTKVYTVDVGRTVTINCPFKTENAPKTKSLYKQIGLSPVLVIDSTGYVNPnymGRIHLDVQGTGqLVFSVVINRLRLS 213
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDN-GVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....
gi 55729233 214 DAGQYLCQAG-YGSNSNKKNADLQ 236
Cdd:cd05716  77 DAGWYWCGVGdDGDRGLTVQVKLV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-127 1.60e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 67.48  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233    24 GPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQ--GASGRCITLISSEGYVSNNYAGRANLTNFPENGTFVVNIAQLS 101
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQppGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 55729233   102 RDDSGRYKCGLGIN-IRGLSFDVSLEV 127
Cdd:pfam07686  82 LSDSGTYTCAVIPSgEGVFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 355-441 1.06e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 62.09  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233   355 SPTVVKGVAGGSVAVLCPYNPKESKSI--KYWCLWEGAQNGRCSLLVESQGQVKEQYEGRLSLLEEPGNGTFTVILNQLT 432
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAStsVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81


                  ....*....
gi 55729233   433 SQDAGFYWC 441
Cdd:pfam07686  82 LSDSGTYTC 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 467-560 3.47e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 57.13  E-value: 3.47e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233    467 PGNVTAVLGQTLKvpchFPCKFSSYEKYWCKWNNTGCQALPSQDKgpskasVNCDENSRLVSLTLNPVTRADEGWYWCGV 546
Cdd:smart00410   1 PPSVTVKEGESVT----LSCEASGSPPPEVTWYKQGGKLLAESGR------FSVSRSGSTSTLTISNVTPEDSGTYTCAA 70

                           90
                   ....*....|....*
gi 55729233    547 KQGHFYGE-TAAVYV 560
Cdd:smart00410  71 TNSSGSASsGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 138-237 2.64e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 54.43  E-value: 2.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233    138 KVYTVDVGRTVTINCPFKTENAPkTKSLYKQiGLSPVLvidstgyvnpnYMGRIHLDVQGTGqlvFSVVINRLRLSDAGQ 217
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPP-EVTWYKQ-GGKLLA-----------ESGRFSVSRSGST---STLTISNVTPEDSGT 65

                           90       100
                   ....*....|....*....|
gi 55729233    218 YLCQAGYGSNSNKKNADLQV 237
Cdd:smart00410  66 YTCAATNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 466-546 5.74e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 5.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233   466 VPGNVTAVLGQTLKVPCHFPCKFS--SYEKYWCKWNNTG----CQALPSQDKGPSKA----SVNCDENSRLVSLTLNPVT 535
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSeaSTSVYWYRQPPGKgptfLIAYYSNGSEEGVKkgrfSGRGDPSNGDGSLTIQNLT 81

                          90
                  ....*....|.
gi 55729233   536 RADEGWYWCGV 546
Cdd:pfam07686  82 LSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-127 5.02e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.49  E-value: 5.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233     25 PEEVNSVEGNSVSITCYYpptSVNRHTRKYWCRQGAsgrcITLISSEGYVSNNYAGRANLTnfpengtfvvnIAQLSRDD 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA---SGSPPPEVTWYKQGG----KLLAESGRFSVSRSGSTSTLT-----------ISNVTPED 62

                           90       100
                   ....*....|....*....|...
gi 55729233    105 SGRYKCGLGINIRGLSFDVSLEV 127
Cdd:smart00410  63 SGTYTCAATNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 141-238 1.52e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 41.67  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233   141 TVDVGRTVTINCPFKTENAPKT--KSLYKQ---IGLSPVLVIDSTGYVNPNYMGRIHLdVQGTGQLVFSVVINRLRLSDA 215
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSMSEAStsVYWYRQppgKGPTFLIAYYSNGSEEGVKKGRFSG-RGDPSNGDGSLTIQNLTLSDS 85

                          90       100
                  ....*....|....*....|....
gi 55729233   216 GQYLCQAGY-GSNSNKKNADLQVL 238
Cdd:pfam07686  86 GTYTCAVIPsGEGVFGKGTRLTVL 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 240-340 2.77e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 40.90  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233   240 PEPQLVYEDlrGSVTFHC--ALGLEVANVAKFLCRESSEENCDVVI----NTLGKraPAFEGRILLNPQDKDGSFSVVIT 313
Cdd:pfam07686   3 PREVTVALG--GSVTLPCtySSSMSEASTSVYWYRQPPGKGPTFLIayysNGSEE--GVKKGRFSGRGDPSNGDGSLTIQ 78

                          90       100
                  ....*....|....*....|....*..
gi 55729233   314 GLRKEDAGRYLCGAHSDGQLQEGSPIQ 340
Cdd:pfam07686  79 NLTLSDSGTYTCAVIPSGEGVFGKGTR 105
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 356-455 4.46e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.80  E-value: 4.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233    356 PTVVKGVAGGSVAVLCPYNPKESKSIkYWCLwegaqngrcsllvesQGQVKEQYEGRLSLLEEPGNGTFTviLNQLTSQD 435
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEV-TWYK---------------QGGKLLAESGRFSVSRSGSTSTLT--ISNVTPED 62

                           90       100
                   ....*....|....*....|...
gi 55729233    436 AGFYWCL---NNGDTRWRTTVEI 455
Cdd:smart00410  63 SGTYTCAatnSSGSASSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 267-337 5.00e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 5.00e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55729233    267 AKFLCRESSEENCDVVINTLGKRAPAFEGRILLNPQDkdGSFSVVITGLRKEDAGRYLCGAHSDGQLQEGS 337
Cdd:smart00410  12 VTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSRSG--STSTLTISNVTPEDSGTYTCAATNSSGSASSG 80
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 464-560 2.27e-35

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 129.44  E-value: 2.27e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 464 LKVPGNVTAVLGQTLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQD--KGPSKASVNCDENSRLVSLTLNPVTRADEGW 541
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEgvVPGGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                        90
                ....*....|....*....
gi 55729233 542 YWCGVKQGHFYGETAAVYV 560
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-126 3.89e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 111.34  E-value: 3.89e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233  24 GPEEVNSVEGNSVSITCYYPPTsvNRHTRKYWCRQGaSGRCITLISSEGYVSNnyaGRANLTNFPENGTFVVNIAQLSRD 103
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWG-SEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....
gi 55729233 104 DSGRYKCGLGIN-IRGLSFDVSLE 126
Cdd:cd05716  77 DAGWYWCGVGDDgDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 356-457 4.77e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 111.34  E-value: 4.77e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 356 PTVVKGVAGGSVAVLCPYNPKESKSIKYWCLWegaQNGRCSLLVESQGQVKEqyeGRLSLLEEPGNGTFTVILNQLTSQD 435
Cdd:cd05716   4 PEVVTGVEGGSVTIQCPYPPKYASSRKYWCKW---GSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|..
gi 55729233 436 AGFYWCLNNGDTRWRTTVEIKI 457
Cdd:cd05716  78 AGWYWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 239-331 9.36e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 93.23  E-value: 9.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 239 KPEPQLVYEDLRGSVTFHCALGLEVANVAKFLCRESSEeNCDVVINTLGKRAPafeGRILLNPQDKDGSFSVVITGLRKE 318
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSE-GCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90
                ....*....|...
gi 55729233 319 DAGRYLCGAHSDG 331
Cdd:cd05716  77 DAGWYWCGVGDDG 89
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 134-236 2.05e-19

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 83.60  E-value: 2.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 134 LNDTKVYTVDVGRTVTINCPFKTENAPKTKSLYKQIGLSPVLVIDSTGYVNPnymGRIHLDVQGTGqLVFSVVINRLRLS 213
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDN-GVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....
gi 55729233 214 DAGQYLCQAG-YGSNSNKKNADLQ 236
Cdd:cd05716  77 DAGWYWCGVGdDGDRGLTVQVKLV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-127 1.60e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 67.48  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233    24 GPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQ--GASGRCITLISSEGYVSNNYAGRANLTNFPENGTFVVNIAQLS 101
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQppGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 55729233   102 RDDSGRYKCGLGIN-IRGLSFDVSLEV 127
Cdd:pfam07686  82 LSDSGTYTCAVIPSgEGVFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 355-441 1.06e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 62.09  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233   355 SPTVVKGVAGGSVAVLCPYNPKESKSI--KYWCLWEGAQNGRCSLLVESQGQVKEQYEGRLSLLEEPGNGTFTVILNQLT 432
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAStsVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81


                  ....*....
gi 55729233   433 SQDAGFYWC 441
Cdd:pfam07686  82 LSDSGTYTC 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 467-560 3.47e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 57.13  E-value: 3.47e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233    467 PGNVTAVLGQTLKvpchFPCKFSSYEKYWCKWNNTGCQALPSQDKgpskasVNCDENSRLVSLTLNPVTRADEGWYWCGV 546
Cdd:smart00410   1 PPSVTVKEGESVT----LSCEASGSPPPEVTWYKQGGKLLAESGR------FSVSRSGSTSTLTISNVTPEDSGTYTCAA 70

                           90
                   ....*....|....*
gi 55729233    547 KQGHFYGE-TAAVYV 560
Cdd:smart00410  71 TNSSGSASsGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 138-237 2.64e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 54.43  E-value: 2.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233    138 KVYTVDVGRTVTINCPFKTENAPkTKSLYKQiGLSPVLvidstgyvnpnYMGRIHLDVQGTGqlvFSVVINRLRLSDAGQ 217
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPP-EVTWYKQ-GGKLLA-----------ESGRFSVSRSGST---STLTISNVTPEDSGT 65

                           90       100
                   ....*....|....*....|
gi 55729233    218 YLCQAGYGSNSNKKNADLQV 237
Cdd:smart00410  66 YTCAATNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 466-546 5.74e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 5.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233   466 VPGNVTAVLGQTLKVPCHFPCKFS--SYEKYWCKWNNTG----CQALPSQDKGPSKA----SVNCDENSRLVSLTLNPVT 535
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSeaSTSVYWYRQPPGKgptfLIAYYSNGSEEGVKkgrfSGRGDPSNGDGSLTIQNLT 81

                          90
                  ....*....|.
gi 55729233   536 RADEGWYWCGV 546
Cdd:pfam07686  82 LSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 141-231 1.33e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 44.63  E-value: 1.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 141 TVDVGRTVTINCPFKTENAPKTKSLYKQI-GLSPVLVI---DSTGYVNPNYMGRIHLDVQGTGQlvFSVVINRLRLSDAG 216
Cdd:cd00099   9 SVQEGESVTLSCEVSSSFSSTYIYWYRQKpGQGPEFLIylsSSKGKTKGGVPGRFSGSRDGTSS--FSLTISNLQPEDSG 86

                        90
                ....*....|....*
gi 55729233 217 QYLCQAGYGSNSNKK 231
Cdd:cd00099  87 TYYCAVSESGGTDKL 101
IgV_PD1 cd16088
Immunoglobulin (Ig)-like domain of Programmed Cell Death 1 (PD1); The members here are ...
 20-111 2.84e-05

Immunoglobulin (Ig)-like domain of Programmed Cell Death 1 (PD1); The members here are composed of the immunoglobulin (Ig)-like domain of Programmed Cell Death 1 (PD1; also known as CD279/cluster of differentiation 279). PD1 is a cell surface receptor that is expressed on T cells and pro-B cells. The protein's structure includes an extracellular IgV domain followed by a transmembrane region and an intracellular tail. Activation of CD4+ T cells, CD8+ T cells, NKT cells, B cells, and monocytes induces PD-1 expression, immediately after which it binds two distinct ligands, PD-L1 (also known as B7-H1 or CD274/cluster of differentiation 274) and PD-L2, also known as B7-DC. PD-1 plays an important role in down regulating the immune system by preventing the activation of T-cells, reducing autoimmunity and promoting self-tolerance. The inhibitory effect of PD-1 is accomplished by promoting apoptosis in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells. A class of drugs that target PD-1, known as the PD-1 inhibitors, activate the immune system to attack tumors and treat cancer. Comparisons between the mouse PD-1 (mPD-1) and human PD-1 (hPD-1) reveals that unlike the mPD-1 which has a conventional IgSF V-set domain, hPD-1 lacks a C" strand, and instead the C' and D strands are connected by a long and flexible loop. In addition, the BC loop is not stabilized by disulfide bonding to the F strand of the ligand binding beta sheet. These differences result in different binding affinities of human and mouse PD-1 for their ligands.


Pssm-ID: 409509  Cd Length: 112  Bit Score: 44.03  E-value: 2.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233  20 SPIFGPEEVNSVEGNSVSITCYYPPTSvnRHTRKYWCRQGASGRCITLIS-SEGYVSNNYAGRANLTNFPENGTFVVNIA 98
Cdd:cd16088   1 PPTFSPALLVVTEGANATFTCSFSNTS--ESFVLNWYRLSPSNQTDKLAAfPEDRSQPGQDWRFRVTQLPNGRDFHMSVV 78

                        90
                ....*....|...
gi 55729233  99 QLSRDDSGRYKCG 111
Cdd:cd16088  79 RARRNDSGTYLCG 91
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 127-230 4.27e-05

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 43.41  E-value: 4.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 127 VSQDPGLLndtkvyTVDVGRTVTINCPFKTENAPktkSL--YKQI-GLSPVLVIDSTGYVNPNYMGRIHLDVQGTGQLvF 203
Cdd:cd04983   1 VTQSPQSL------SVQEGENVTLNCNYSTSTFY---YLfwYRQYpGQGPQFLIYISSDSGNKKKGRFSATLDKSRKS-S 70

                        90       100
                ....*....|....*....|....*..
gi 55729233 204 SVVINRLRLSDAGQYLCQAGYGSNSNK 230
Cdd:cd04983  71 SLHISAAQLSDSAVYFCALSESGGTGK 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-127 5.02e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.49  E-value: 5.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233     25 PEEVNSVEGNSVSITCYYpptSVNRHTRKYWCRQGAsgrcITLISSEGYVSNNYAGRANLTnfpengtfvvnIAQLSRDD 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA---SGSPPPEVTWYKQGG----KLLAESGRFSVSRSGSTSTLT-----------ISNVTPED 62

                           90       100
                   ....*....|....*....|...
gi 55729233    105 SGRYKCGLGINIRGLSFDVSLEV 127
Cdd:smart00410  63 SGTYTCAATNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 141-238 1.52e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 41.67  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233   141 TVDVGRTVTINCPFKTENAPKT--KSLYKQ---IGLSPVLVIDSTGYVNPNYMGRIHLdVQGTGQLVFSVVINRLRLSDA 215
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSMSEAStsVYWYRQppgKGPTFLIAYYSNGSEEGVKKGRFSG-RGDPSNGDGSLTIQNLTLSDS 85

                          90       100
                  ....*....|....*....|....
gi 55729233   216 GQYLCQAGY-GSNSNKKNADLQVL 238
Cdd:pfam07686  86 GTYTCAVIPsGEGVFGKGTRLTVL 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 240-340 2.77e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 40.90  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233   240 PEPQLVYEDlrGSVTFHC--ALGLEVANVAKFLCRESSEENCDVVI----NTLGKraPAFEGRILLNPQDKDGSFSVVIT 313
Cdd:pfam07686   3 PREVTVALG--GSVTLPCtySSSMSEASTSVYWYRQPPGKGPTFLIayysNGSEE--GVKKGRFSGRGDPSNGDGSLTIQ 78

                          90       100
                  ....*....|....*....|....*..
gi 55729233   314 GLRKEDAGRYLCGAHSDGQLQEGSPIQ 340
Cdd:pfam07686  79 NLTLSDSGTYTCAVIPSGEGVFGKGTR 105
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 356-455 4.46e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.80  E-value: 4.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233    356 PTVVKGVAGGSVAVLCPYNPKESKSIkYWCLwegaqngrcsllvesQGQVKEQYEGRLSLLEEPGNGTFTviLNQLTSQD 435
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEV-TWYK---------------QGGKLLAESGRFSVSRSGSTSTLT--ISNVTPED 62

                           90       100
                   ....*....|....*....|...
gi 55729233    436 AGFYWCL---NNGDTRWRTTVEI 455
Cdd:smart00410  63 SGTYTCAatnSSGSASSGTTLTV 85
Ig_Neurocan cd05902
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 365-441 5.22e-04

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Unlike aggrecan which is widely distributed in connective tissue and extracellular matrices, neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409483  Cd Length: 121  Bit Score: 40.59  E-value: 5.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 365 GSVAVLC-------PYNPKESKSIKYWCLWEGAQNGRCSLLVESQG--QVKEQYEGRLSLLEEPGN-GTFTVILNQLTSQ 434
Cdd:cd05902  13 SSVLLPCvftlppsASSPPEGPRIKWTKLSTSGGQQQRPVLVARDNvvRVAKAFQGRVSLPGYPKNrYNASLVLSRLRYS 92


                ....*..
gi 55729233 435 DAGFYWC 441
Cdd:cd05902  93 DSGTYRC 99
IgI_2_JAM1 cd20950
Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF ...
 141-226 6.01e-04

Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains; The members here are composed of the second Ig-like domain of Junctional adhesion molecule-1 (JAM1). JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The second Ig-like domain of JAM1 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous but lacks a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors.


Pssm-ID: 409542  Cd Length: 97  Bit Score: 39.61  E-value: 6.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 141 TVDVGRTVTINCPFKTENAPKTKSLYKQIGLSPVLVIDSTGYVNPNYMgrihLDVQgTGQLVFSvvinRLRLSDAGQYLC 220
Cdd:cd20950   8 SATIGNRAVLTCSEPDGSPPSEYTWFKDGVVMPTNPKSTRAFSNSSYS----LDPT-TGELVFD----PLSASDTGEYSC 78


                ....*...
gi 55729233 221 QA--GYGS 226
Cdd:cd20950  79 EArnGYGT 86
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 240-325 1.13e-03

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 39.23  E-value: 1.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 240 PEPQLVYEDLRGSVTFHCALGLEVANVAKFLCR------ESSEENCDVVINTLGKRAPAF---EGRILLNpQDKDGSFSV 310
Cdd:cd05877   2 TVQAKVFSHRGGNVTLPCRYHYEPELSAPRKIRvkwtklEVDYAKEEDVLVAIGTRHKSYgsyQGRVFLR-RADDLDASL 80

                        90
                ....*....|....*
gi 55729233 311 VITGLRKEDAGRYLC 325
Cdd:cd05877  81 VITDLRLEDYGRYRC 95
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 25-110 1.36e-03

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 38.97  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233  25 PEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGASGRCITLISSEGY---VSNNYAGRANLTNFP---ENGTfvVNIA 98
Cdd:cd05718   6 PTEVTGFLGGSVTLPCSLTSPGTTKITQVTWMKIGAGSSQNVAVFHPQYgpsVPNPYAERVEFLAARlglRNAT--LRIR 83

                        90
                ....*....|..
gi 55729233  99 QLSRDDSGRYKC 110
Cdd:cd05718  84 NLRVEDEGNYIC 95
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 275-334 1.95e-03

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 38.59  E-value: 1.95e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55729233 275 SEENCDVVINTLGKRA-----PAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYLCGAHSDGQLQ 334
Cdd:cd20960  43 SDKVEKVVITYSGDRVynhyyPALKGRVAFTSNDLSGDASLNISNLKLSDTGTYQCKVKKAPGYA 107
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 135-254 2.92e-03

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 38.08  E-value: 2.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 135 NDTKVYTVDvGRTVTINCPFKTENAPKTKSLY--KQIGLSP-----VLVIDSTGYVNPNY---MGRIHLdvQGTGQLVFS 204
Cdd:cd05877   3 VQAKVFSHR-GGNVTLPCRYHYEPELSAPRKIrvKWTKLEVdyakeEDVLVAIGTRHKSYgsyQGRVFL--RRADDLDAS 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 55729233 205 VVINRLRLSDAGQYLCQAGYGsnsnkknadlqvLKPEPQLVYEDLRGSVT 254
Cdd:cd05877  80 LVITDLRLEDYGRYRCEVIDG------------LEDESVVVALRLRGVVF 117
Ig_CSPGs_LP_like cd05714
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage ...
 145-225 3.29e-03

Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409379  Cd Length: 123  Bit Score: 38.35  E-value: 3.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55729233 145 GRTVTINCPFKTENAP-------------KTKSLYKQIGLSPVLV-IDSTGYVNPNYMGRIHLDVQGTGQLVFSVVINRL 210
Cdd:cd05714  12 GGNVTLPCKFYRDPTAfgsgihkirikwtKLTSDSGYLKEVDVLVaMGNVVYHKKTYGGRVSVPLKPGSDSDASLVITDL 91

                        90
                ....*....|....*
gi 55729233 211 RLSDAGQYLCQAGYG 225
Cdd:cd05714  92 TASDYGLYRCEVIEG 106
Ig_Neurocan cd05902
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 173-237 4.57e-03

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Unlike aggrecan which is widely distributed in connective tissue and extracellular matrices, neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409483  Cd Length: 121  Bit Score: 37.89  E-value: 4.57e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55729233 173 PVLVI-DSTGYVNPNYMGRIHLDVQGTGQLVFSVVINRLRLSDAGQYLCQAGYGSNSNKKNADLQV 237
Cdd:cd05902  51 PVLVArDNVVRVAKAFQGRVSLPGYPKNRYNASLVLSRLRYSDSGTYRCEVVLGINDEQDTVPLEV 116
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 267-337 5.00e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 5.00e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55729233    267 AKFLCRESSEENCDVVINTLGKRAPAFEGRILLNPQDkdGSFSVVITGLRKEDAGRYLCGAHSDGQLQEGS 337
Cdd:smart00410  12 VTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSRSG--STSTLTISNVTPEDSGTYTCAATNSSGSASSG 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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