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Conserved domains on  [gi|59668580|emb|CAI53713|]
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pilE protein, partial [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]

Protein Classification

type IV pilin protein( domain architecture ID 11471939)

type IV pilin protein similar to fimbrial protein PilE, which is required for pilus biogenesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
8-99 8.52e-29

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


:

Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 100.92  E-value: 8.52e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59668580   8 MKNS-RMKQSAFTLVEVLISMVIMGILVSIAYPSYLQYIQKSRRADAHATLTQDQIILERCYSQNFSYAAACGALPAFpq 86
Cdd:COG4968   1 MKKRmRRRQRGFTLIELMIVVAIIGILAAIAIPSYQDYVERARRAEAKAALLELAQAQERYYADNGSYPSALADLGLP-- 78

                        90
                ....*....|...
gi 59668580  87 TTPNGYYTINISN 99
Cdd:COG4968  79 ASTSGYYTISIAA 91
 
Name Accession Description Interval E-value
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
8-99 8.52e-29

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 100.92  E-value: 8.52e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59668580   8 MKNS-RMKQSAFTLVEVLISMVIMGILVSIAYPSYLQYIQKSRRADAHATLTQDQIILERCYSQNFSYAAACGALPAFpq 86
Cdd:COG4968   1 MKKRmRRRQRGFTLIELMIVVAIIGILAAIAIPSYQDYVERARRAEAKAALLELAQAQERYYADNGSYPSALADLGLP-- 78

                        90
                ....*....|...
gi 59668580  87 TTPNGYYTINISN 99
Cdd:COG4968  79 ASTSGYYTISIAA 91
ComP_DUS pfam16732
Type IV minor pilin ComP, DNA uptake sequence receptor; ComP-DUS is the DNA-uptake sequence ...
 44-120 1.07e-14

Type IV minor pilin ComP, DNA uptake sequence receptor; ComP-DUS is the DNA-uptake sequence receptor of pathogenic Proteobacteria. ComP is a type IV minor pilin -site on the minor type IV pilin, C one of three minor (low abundance) pilins in pathogenic Proteobacteria Neisseria species (with PilV and PilX). These modulate Tfp-mediated properties without affecting Tfp biogenesis. ComP plays a prominent role in competence at the level of DNA uptake. Comp is exposed on the surface of Neisseria filaments, and it is this that recognizes homotypic DNA through genus-specific DNA uptake sequence (DUS) motifs.


Pssm-ID: 435546  Cd Length: 83  Bit Score: 63.87  E-value: 1.07e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59668580    44 YIQKSRRADAHATLTQDQIILERCYSQNFSYAAACGALPAF-PQTTPNGYYTINISNLTATTYTLTATPVGTQAKDTE 120
Cdd:pfam16732   1 YVLKSRRADAKAALLEAAQAQERYYTQNGTYADLTALGDLAsSPTSGNGYYTISLSAATATTYTLTATPTGGQAGDSD 78
PRK10574 PRK10574
putative major pilin subunit; Provisional
 12-47 1.61e-07

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 46.95  E-value: 1.61e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 59668580   12 RMKQSAFTLVEVLISMVIMGILVSIAYPSYLQYIQK 47
Cdd:PRK10574   1 MDKQRGFTLIELMVVIAIIAILSAIGIPAYQNYLQK 36
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 15-38 2.29e-05

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 38.44  E-value: 2.29e-05
                          10        20
                  ....*....|....*....|....
gi 59668580    15 QSAFTLVEVLISMVIMGILVSIAY 38
Cdd:TIGR02532   1 QRGFTLIELLVVLAILGILALIAL 24
 
Name Accession Description Interval E-value
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
8-99 8.52e-29

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 100.92  E-value: 8.52e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59668580   8 MKNS-RMKQSAFTLVEVLISMVIMGILVSIAYPSYLQYIQKSRRADAHATLTQDQIILERCYSQNFSYAAACGALPAFpq 86
Cdd:COG4968   1 MKKRmRRRQRGFTLIELMIVVAIIGILAAIAIPSYQDYVERARRAEAKAALLELAQAQERYYADNGSYPSALADLGLP-- 78

                        90
                ....*....|...
gi 59668580  87 TTPNGYYTINISN 99
Cdd:COG4968  79 ASTSGYYTISIAA 91
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 8-74 7.25e-15

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 64.93  E-value: 7.25e-15
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 59668580   8 MKNSRMKQSAFTLVEVLISMVIMGILVSIAYPSYLQYIQKSRRADAHATLTQDQIILERCYSQNFSY 74
Cdd:COG2165   3 LRRRRRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDNGRY 69
ComP_DUS pfam16732
Type IV minor pilin ComP, DNA uptake sequence receptor; ComP-DUS is the DNA-uptake sequence ...
 44-120 1.07e-14

Type IV minor pilin ComP, DNA uptake sequence receptor; ComP-DUS is the DNA-uptake sequence receptor of pathogenic Proteobacteria. ComP is a type IV minor pilin -site on the minor type IV pilin, C one of three minor (low abundance) pilins in pathogenic Proteobacteria Neisseria species (with PilV and PilX). These modulate Tfp-mediated properties without affecting Tfp biogenesis. ComP plays a prominent role in competence at the level of DNA uptake. Comp is exposed on the surface of Neisseria filaments, and it is this that recognizes homotypic DNA through genus-specific DNA uptake sequence (DUS) motifs.


Pssm-ID: 435546  Cd Length: 83  Bit Score: 63.87  E-value: 1.07e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59668580    44 YIQKSRRADAHATLTQDQIILERCYSQNFSYAAACGALPAF-PQTTPNGYYTINISNLTATTYTLTATPVGTQAKDTE 120
Cdd:pfam16732   1 YVLKSRRADAKAALLEAAQAQERYYTQNGTYADLTALGDLAsSPTSGNGYYTISLSAATATTYTLTATPTGGQAGDSD 78
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
12-92 1.72e-13

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 62.03  E-value: 1.72e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59668580  12 RMKQSAFTLVEVLISMVIMGILVSIAYPSYLQYIQKSRRADAHATLTQDQIILERCYSQNFSYAAACGALPAFPQTTPNG 91
Cdd:COG4969   2 KKKQKGFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALALASPLKTAVEECALENGSLPNCNAGDNGLPATIATK 81


                .
gi 59668580  92 Y 92
Cdd:COG4969  82 Y 82
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
8-53 2.96e-12

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 57.16  E-value: 2.96e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 59668580   8 MKNSRMKQSAFTLVEVLISMVIMGILVSIAYPSYLQYIQKSRRADA 53
Cdd:COG4970   1 MKRLRRRQRGFTLIELLVVLAILAILAAIAVPSFSSLIARQRLRAA 46
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 8-60 3.99e-10

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 53.10  E-value: 3.99e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 59668580   8 MKNSRMKQSAFTLVEVLISMVIMGILVSIAYpSYLQYIQKSR-RADAHATLTQD 60
Cdd:COG4795   1 MKRARRRQRGFTLLELLVALAIFALLLLAAY-RGLDSVLRSReRLEQQAERLQE 53
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 12-38 1.04e-07

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 44.67  E-value: 1.04e-07
                          10        20
                  ....*....|....*....|....*..
gi 59668580    12 RMKQSAFTLVEVLISMVIMGILVSIAY 38
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
PRK10574 PRK10574
putative major pilin subunit; Provisional
 12-47 1.61e-07

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 46.95  E-value: 1.61e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 59668580   12 RMKQSAFTLVEVLISMVIMGILVSIAYPSYLQYIQK 47
Cdd:PRK10574   1 MDKQRGFTLIELMVVIAIIAILSAIGIPAYQNYLQK 36
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
8-49 7.39e-07

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 44.15  E-value: 7.39e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 59668580   8 MKNSRMKQSAFTLVEVLISMVIMGILVSIAYPSYLQYIQKSR 49
Cdd:COG4537   4 KKRKLKKEKGFTLIEMLIVLLIISILLLIAVPNLTKQRETAQ 45
PilW COG4966
Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];
12-60 3.40e-06

Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];


Pssm-ID: 443992 [Multi-domain]  Cd Length: 158  Bit Score: 43.63  E-value: 3.40e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 59668580  12 RMKQSAFTLVEVLISMVIMGILVSIAYPSYLQYIQKSRRADAHATLTQD 60
Cdd:COG4966   1 RRRQRGFTLVELMVALAIGLIVLAAVLQLFLSSRRSYRTQEALARLQEN 49
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 15-38 2.29e-05

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 38.44  E-value: 2.29e-05
                          10        20
                  ....*....|....*....|....
gi 59668580    15 QSAFTLVEVLISMVIMGILVSIAY 38
Cdd:TIGR02532   1 QRGFTLIELLVVLAILGILALIAL 24
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
8-62 1.32e-04

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 38.04  E-value: 1.32e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59668580   8 MKNSRM--KQSAFTLVEVLISMVIMGI-LVSIA--YPSYLQYIQKSR-RADAhATLTQDQI 62
Cdd:COG4967   1 MSRRRRrrRQRGFTLIEVLVALVILSIgLLGLAglQAASLRSSQDARqRTQA-ALLAQDLL 60
PRK10506 PRK10506
prepilin peptidase-dependent protein;
8-53 1.36e-04

prepilin peptidase-dependent protein;


Pssm-ID: 236704 [Multi-domain]  Cd Length: 162  Bit Score: 39.21  E-value: 1.36e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 59668580    8 MKNSRMKQSAFTLVEVLISMVIMGILVSIAYPSYLQYIQKSRRADA 53
Cdd:PRK10506   1 MKRSMKKQRGYTLIELLVVMTIVSILSAWGLYGWQRWQQRQRLWQT 46
typeII_sec_gspH TIGR01708
type II secretion system protein H; This model represents GspH, protein H of the main terminal ...
 14-40 4.72e-04

type II secretion system protein H; This model represents GspH, protein H of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130769 [Multi-domain]  Cd Length: 143  Bit Score: 37.54  E-value: 4.72e-04
                          10        20
                  ....*....|....*....|....*..
gi 59668580    14 KQSAFTLVEVLISMVIMGILVSIAYPS 40
Cdd:TIGR01708   2 RQSGFTLIELLVVLAIMGLVAAAAALS 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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