conserved hypothetical sugar phosphate isomerase protein [Candidatus Kuenenia stuttgartiensis]
SIS domain-containing protein( domain architecture ID 10141873)
SIS (sugar isomerase) domain-containing protein similar to Mycobacterium gastri 6-phospho-3-hexuloisomerase (PHI, EC 5.3.1.27) that catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
SIS_PHI | cd05005 | Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ... |
19-197 | 9.60e-86 | ||||
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI. : Pssm-ID: 240138 [Multi-domain] Cd Length: 179 Bit Score: 250.57 E-value: 9.60e-86
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Name | Accession | Description | Interval | E-value | ||||
SIS_PHI | cd05005 | Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ... |
19-197 | 9.60e-86 | ||||
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI. Pssm-ID: 240138 [Multi-domain] Cd Length: 179 Bit Score: 250.57 E-value: 9.60e-86
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RuMP_HxlB | TIGR03127 | 6-phospho 3-hexuloisomerase; Members of this protein family are 6-phospho 3-hexuloisomerase ... |
23-200 | 4.30e-62 | ||||
6-phospho 3-hexuloisomerase; Members of this protein family are 6-phospho 3-hexuloisomerase (PHI), or the PHI domain of a fusion protein. This enzyme is part of the ribulose monophosphate (RuMP) pathway, which in one direction removes the toxic metabolite formaldehyde by assimilation into fructose-6-phosphate. In the other direction, in species lacking a complete pentose phosphate pathway, the RuMP pathway yields ribulose-5-phosphate, necessary for nucleotide biosynthesis, at the cost of also yielding formaldehyde. These latter species tend usually have a formaldehyde-activating enzyme to attach formaldehyde to the C1 carrier tetrahydromethanopterin. Pssm-ID: 132171 [Multi-domain] Cd Length: 179 Bit Score: 190.60 E-value: 4.30e-62
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RpiR | COG1737 | DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ... |
29-150 | 1.01e-23 | ||||
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription]; Pssm-ID: 441343 [Multi-domain] Cd Length: 286 Bit Score: 94.99 E-value: 1.01e-23
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SIS | pfam01380 | SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
47-149 | 3.02e-17 | ||||
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway. Pssm-ID: 426230 [Multi-domain] Cd Length: 131 Bit Score: 74.26 E-value: 3.02e-17
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PRK15482 | PRK15482 | HTH-type transcriptional regulator MurR; |
26-164 | 1.14e-12 | ||||
HTH-type transcriptional regulator MurR; Pssm-ID: 185379 [Multi-domain] Cd Length: 285 Bit Score: 65.10 E-value: 1.14e-12
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Name | Accession | Description | Interval | E-value | ||||
SIS_PHI | cd05005 | Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ... |
19-197 | 9.60e-86 | ||||
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI. Pssm-ID: 240138 [Multi-domain] Cd Length: 179 Bit Score: 250.57 E-value: 9.60e-86
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RuMP_HxlB | TIGR03127 | 6-phospho 3-hexuloisomerase; Members of this protein family are 6-phospho 3-hexuloisomerase ... |
23-200 | 4.30e-62 | ||||
6-phospho 3-hexuloisomerase; Members of this protein family are 6-phospho 3-hexuloisomerase (PHI), or the PHI domain of a fusion protein. This enzyme is part of the ribulose monophosphate (RuMP) pathway, which in one direction removes the toxic metabolite formaldehyde by assimilation into fructose-6-phosphate. In the other direction, in species lacking a complete pentose phosphate pathway, the RuMP pathway yields ribulose-5-phosphate, necessary for nucleotide biosynthesis, at the cost of also yielding formaldehyde. These latter species tend usually have a formaldehyde-activating enzyme to attach formaldehyde to the C1 carrier tetrahydromethanopterin. Pssm-ID: 132171 [Multi-domain] Cd Length: 179 Bit Score: 190.60 E-value: 4.30e-62
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RpiR | COG1737 | DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ... |
29-150 | 1.01e-23 | ||||
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription]; Pssm-ID: 441343 [Multi-domain] Cd Length: 286 Bit Score: 94.99 E-value: 1.01e-23
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SIS_RpiR | cd05013 | RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ... |
39-149 | 1.70e-22 | ||||
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate. Pssm-ID: 240144 [Multi-domain] Cd Length: 139 Bit Score: 88.05 E-value: 1.70e-22
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SIS | pfam01380 | SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
47-149 | 3.02e-17 | ||||
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway. Pssm-ID: 426230 [Multi-domain] Cd Length: 131 Bit Score: 74.26 E-value: 3.02e-17
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PRK15482 | PRK15482 | HTH-type transcriptional regulator MurR; |
26-164 | 1.14e-12 | ||||
HTH-type transcriptional regulator MurR; Pssm-ID: 185379 [Multi-domain] Cd Length: 285 Bit Score: 65.10 E-value: 1.14e-12
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PRK11557 | PRK11557 | MurR/RpiR family transcriptional regulator; |
29-139 | 2.62e-12 | ||||
MurR/RpiR family transcriptional regulator; Pssm-ID: 183195 [Multi-domain] Cd Length: 278 Bit Score: 64.02 E-value: 2.62e-12
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SIS_Kpsf | cd05014 | KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ... |
54-148 | 2.83e-12 | ||||
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway. Pssm-ID: 240145 [Multi-domain] Cd Length: 128 Bit Score: 61.02 E-value: 2.83e-12
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GutQ | COG0794 | D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ... |
27-148 | 4.30e-12 | ||||
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440557 [Multi-domain] Cd Length: 317 Bit Score: 63.46 E-value: 4.30e-12
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AgaS | COG2222 | Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ... |
26-145 | 5.50e-09 | ||||
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 441824 [Multi-domain] Cd Length: 336 Bit Score: 54.52 E-value: 5.50e-09
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PRK14101 | PRK14101 | bifunctional transcriptional regulator/glucokinase; |
23-150 | 1.17e-08 | ||||
bifunctional transcriptional regulator/glucokinase; Pssm-ID: 184507 [Multi-domain] Cd Length: 638 Bit Score: 54.15 E-value: 1.17e-08
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SIS_PGI_PMI_1 | cd05017 | The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ... |
53-128 | 1.29e-08 | ||||
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain. Pssm-ID: 240148 [Multi-domain] Cd Length: 119 Bit Score: 51.11 E-value: 1.29e-08
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PRK08674 | PRK08674 | bifunctional phosphoglucose/phosphomannose isomerase; Validated |
47-128 | 1.87e-08 | ||||
bifunctional phosphoglucose/phosphomannose isomerase; Validated Pssm-ID: 181536 [Multi-domain] Cd Length: 337 Bit Score: 53.06 E-value: 1.87e-08
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SIS_GlmS_GlmD_1 | cd05008 | SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ... |
53-145 | 4.21e-08 | ||||
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction. Pssm-ID: 240141 [Multi-domain] Cd Length: 126 Bit Score: 49.80 E-value: 4.21e-08
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PRK11337 | PRK11337 | MurR/RpiR family transcriptional regulator; |
12-148 | 8.70e-07 | ||||
MurR/RpiR family transcriptional regulator; Pssm-ID: 183089 [Multi-domain] Cd Length: 292 Bit Score: 48.22 E-value: 8.70e-07
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SIS_1 | cd05710 | A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ... |
86-142 | 1.78e-06 | ||||
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Pssm-ID: 240214 [Multi-domain] Cd Length: 120 Bit Score: 45.26 E-value: 1.78e-06
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SIS_Etherase | cd05007 | N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ... |
90-146 | 2.05e-06 | ||||
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate. Pssm-ID: 240140 [Multi-domain] Cd Length: 257 Bit Score: 46.75 E-value: 2.05e-06
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SIS | cd04795 | SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
54-127 | 3.76e-06 | ||||
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Pssm-ID: 240112 [Multi-domain] Cd Length: 87 Bit Score: 43.52 E-value: 3.76e-06
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G6PI_arch | TIGR02128 | bifunctional phosphoglucose/phosphomannose isomerase; This bifunctional isomerase is a member ... |
52-128 | 8.77e-06 | ||||
bifunctional phosphoglucose/phosphomannose isomerase; This bifunctional isomerase is a member of the larger PGI superfamily and only distantly related to other glucose-6-phosphate isomerases. The family is limited to the archaea. Pssm-ID: 273988 [Multi-domain] Cd Length: 308 Bit Score: 45.12 E-value: 8.77e-06
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PRK11302 | PRK11302 | DNA-binding transcriptional regulator HexR; Provisional |
90-148 | 2.06e-05 | ||||
DNA-binding transcriptional regulator HexR; Provisional Pssm-ID: 183082 [Multi-domain] Cd Length: 284 Bit Score: 43.83 E-value: 2.06e-05
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gutQ | PRK11543 | arabinose-5-phosphate isomerase GutQ; |
19-147 | 2.57e-05 | ||||
arabinose-5-phosphate isomerase GutQ; Pssm-ID: 183186 [Multi-domain] Cd Length: 321 Bit Score: 43.60 E-value: 2.57e-05
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murQ | PRK05441 | N-acetylmuramic acid-6-phosphate etherase; Reviewed |
90-146 | 3.69e-05 | ||||
N-acetylmuramic acid-6-phosphate etherase; Reviewed Pssm-ID: 235467 [Multi-domain] Cd Length: 299 Bit Score: 43.23 E-value: 3.69e-05
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PRK13938 | PRK13938 | phosphoheptose isomerase; Provisional |
94-148 | 2.09e-04 | ||||
phosphoheptose isomerase; Provisional Pssm-ID: 139997 [Multi-domain] Cd Length: 196 Bit Score: 40.49 E-value: 2.09e-04
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GmhA | COG0279 | Phosphoheptose isomerase [Carbohydrate transport and metabolism]; |
93-149 | 1.07e-03 | ||||
Phosphoheptose isomerase [Carbohydrate transport and metabolism]; Pssm-ID: 440048 [Multi-domain] Cd Length: 189 Bit Score: 38.17 E-value: 1.07e-03
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SIS_GmhA | cd05006 | Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ... |
93-149 | 2.43e-03 | ||||
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh). Pssm-ID: 240139 [Multi-domain] Cd Length: 177 Bit Score: 37.10 E-value: 2.43e-03
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Blast search parameters | ||||
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