|
Name |
Accession |
Description |
Interval |
E-value |
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
20-371 |
5.82e-115 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 338.79 E-value: 5.82e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 20 DVVTPINVATTYKYNDENLTKladlDLSTDYFRTPVYSRLSHPNSEQVEELIGSI-TDAHAIAYSSGLGAIFAAFTHLNP 98
Cdd:cd00614 2 AVAPPIYQTSTFVFPSPAEAA----DLFALREGGYIYSRIGNPTVDALEKKLAALeGGEAALAFSSGMAAISTVLLALLK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 99 S---KVAIGKGYHGTHGIADLFTRIKGLTQISIN-DDLNQL-----GKDDVIFLETPVNPDGEVFDIQYYADIAHSKGAK 169
Cdd:cd00614 78 AgdhVVASDDLYGGTYRLFERLLPKLGIEVTFVDpDDPEALeaaikPETKLVYVESPTNPTLKVVDIEAIAELAHEHGAL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 170 LVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAKFELVSDRVYLGTNIANLESFLLIRSLRTYE 249
Cdd:cd00614 158 LVVDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 250 LRILQQSRNATEIVEFLSKNrekyPNITKITHGSL---QTEEFVKKQQPnGHSPVFAIELD-SEENAKAFPSKLKYFHHA 325
Cdd:cd00614 238 LRMERHSENALKVAEFLEKH----PKVERVYYPGLpshPQHELAKKQMS-GYGGVFSFELKgGLEAAKKFLNALKLFSLA 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2696122183 326 TSLGGVESLIEWRAMSDSS-----------CSPKLLRVSVGIENVKDLIADFQQALD 371
Cdd:cd00614 313 VSLGGVESLVEHPASMTHSqlppeeraaagITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
3-373 |
9.28e-95 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 288.10 E-value: 9.28e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 3 GISTNLIHAADGQSRVTD-VVTPINVATTYKYNDENLTKLADLDLSTDYfrtpVYSRLSHPNSEQVEELIGSITDA-HAI 80
Cdd:COG0626 2 GPATRAVHAGRDPDPQTGaVSPPIYLTSTFVFPSAEALAARFAGEEGGY----IYSRYGNPTRRALEEALAALEGGeAAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 81 AYSSGLGAIFAA-FTHLNPSK--VAIGKGYHGTHGIAD-LFTRIkGLT----QISINDDLNQL--GKDDVIFLETPVNPD 150
Cdd:COG0626 78 AFASGMAAISAVlLALLKAGDhvVASDDLYGGTRRLLDkVLARF-GIEvtfvDPTDLAAVEAAirPNTKLVFLETPSNPT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 151 GEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAKFELVSDRVYLG 230
Cdd:COG0626 157 LEVVDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 231 TNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLSKNrekyPNITKITHGSLQTE---EFVKKQQpNGHSPVFAIELD 307
Cdd:COG0626 237 AVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAH----PAVARVYYPGLPSHpghELAKRQM-SGFGGMLSFELK 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2696122183 308 -SEENAKAFPSKLKYFHHATSLGGVESLIEWRA-MSDSSCSPK----------LLRVSVGIENVKDLIADFQQALDTL 373
Cdd:COG0626 312 gGREAARRFLDALKLFTLAVSLGGVESLITHPAtMTHRSLPPEeraalgitdgLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
5-371 |
2.00e-78 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 245.61 E-value: 2.00e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 5 STNLIHAADGQSRVTD-VVTPINVATTYKYNDENLtkladldlSTDYFrtpvYSRLSHPNSEQVEELIGSITDA-HAIAY 82
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGaVSVPIYLTSTYVFDFAGE--------EGGYD----YSRSGNPTRDVLEERIAALEGGaAALAF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 83 SSGLGAIFAAFTHLNPSK---VAIGKGYHGTHgiaDLFTRIK---GLTQISIN-DDLNQLGK-----DDVIFLETPVNPD 150
Cdd:pfam01053 69 SSGMAAITAAILALLKAGdhiVATDDLYGGTY---RLFNKVLprfGIEVTFVDtSDPEDLEAaikpnTKAVYLETPTNPL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 151 GEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAKFELVSDRVYLG 230
Cdd:pfam01053 146 LKVVDIEAIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 231 TNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQTE---EFVKKQQpNGHSPVFAIELD 307
Cdd:pfam01053 226 AVLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFL----ESHPKVEKVYYPGLPSHpghELAKRQM-KGFGGMLSFELK 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2696122183 308 SE-ENAKAFPSKLKYFHHATSLGGVESLIEWRA-MSDSSCSPK----------LLRVSVGIENVKDLIADFQQALD 371
Cdd:pfam01053 301 GGlEAAKKFLDNLKLFSLAVSLGGVESLISHPAtMTHASIPPEereaagitddLIRLSVGIEDVDDLIADLKQALE 376
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
22-370 |
1.56e-60 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 199.67 E-value: 1.56e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 22 VTPINVATTYKYNDENLTKLADldlstdyfrtpvYSRLSHPNSEQVEELIGSITDAH-AIAYSSGLGAIFAAFTHLNPSK 100
Cdd:TIGR01329 19 SMPIYQTATFKQPLAIENGPYD------------YTRSGNPTRTALESLLAKLDKADrAFAFSSGMAALDVITRLLNNGD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 101 VAIGKG--YHGTHGIADLFTRIKGLTQISIN----DDLNQ-LG-KDDVIFLETPVNPDGEVFDIQYYADIAHSKGAKLVI 172
Cdd:TIGR01329 87 EIIAGDdlYGGTDRLLTQVVPRSGVVVVHVDttdlDKVKAaLGpKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 173 DSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKakfelVSDRVYL-----GTNIANLESFLLIRSLRT 247
Cdd:TIGR01329 167 DNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEE-----IAKKVYFlqnstGSGLAPFDCWLLLRGIKT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 248 YELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQTEE--FVKKQQPNGHSPVFAIELDSEENAKAFPSKLKYFHHA 325
Cdd:TIGR01329 242 LAIRIEKQQENARAIAMFL----STHPRVKKVRYAGLPSHPgfHLHFSQAKGAGSVLSFETGSVALSKRLVEATKLFSIT 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2696122183 326 TSLGGVESLIEWRA-MSDSSCSPK----------LLRVSVGIENVKDLIADFQQAL 370
Cdd:TIGR01329 318 VSFGSVNSLISMPCfMSHASIPAEvreerglpedLVRLSVGIEDVDDLISDLDIAF 373
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
2-371 |
1.03e-59 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 197.56 E-value: 1.03e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 2 TGISTNLIHAadGQS---RVTDVVTPINVATTYKYNDENltkladlDLSTDYfrtpVYSRLSHPNSEQVEELIGSITDA- 77
Cdd:PRK07811 11 QGFATRAIHA--GYEpdpATGAVNPPIYASSTFAQDGVG-------GLRGGY----EYARTGNPTRTALEEQLAALEGGa 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 78 HAIAYSSGLGAIFAAF-THLNP-SKVAIGK-GYHGTHG-IADLFTRIK-GLTQISINDdLNQLG-----KDDVIFLETPV 147
Cdd:PRK07811 78 YGRAFSSGMAATDCLLrAVLRPgDHIVIPNdAYGGTFRlIDKVFTRWGvEYTPVDLSD-LDAVRaaitpRTKLIWVETPT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 148 NPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPkakfELVSDRV 227
Cdd:PRK07811 157 NPLLSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDE----ELDEAFA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 228 YL----GTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQTE--EFVKKQQPNGHSPV 301
Cdd:PRK07811 233 FLqngaGAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFL----AGHPEVSTVLYPGLPSHpgHEVAARQMRGFGGM 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2696122183 302 FAIEL-DSEENAKAFPSKLKYFHHATSLGGVESLIEW-RAMSDSSCS------PK-LLRVSVGIENVKDLIADFQQALD 371
Cdd:PRK07811 309 VSVRLaGGEEAARDFCARTKVFTLAESLGGVESLIEHpSAMTHASTAgsqlevPDdLVRLSVGIEDVADLLADLEQALG 387
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
20-373 |
2.78e-59 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 196.89 E-value: 2.78e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 20 DVVTPINVATTYKYNDENltklADLDLSTDYFRTPVYSRLSHPNSEQVEELIGSITDAH-AIAYSSGLGAIFAA-FTHLN 97
Cdd:PRK08249 26 ATQVPVVLSVAYGYDDID----EWYDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEaATAFSTGMAAISNTlYTFLK 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 98 PSK--VAIGKGYHGTHGIadlFTRIKGLTQISI----NDDLNQLGKD-----DVIFLETPVNPDGEVFDIQYYADIAHSK 166
Cdd:PRK08249 102 PGDrvVSIKDTYGGTNKI---FTEFLPRMGVDVtlceTGDHEQIEAEiakgcDLLYLETPTNPTLKIVDIERLAAAAKKV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 167 GAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLtkDPKAKFELVsdRVYLGTNIANLESF---LLIR 243
Cdd:PRK08249 179 GALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVC--GSKELMEQV--YHYREINGATMDPMsayLILR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 244 SLRTYELRILQQSRNATEIVEFLsKNREK-----YPNITkiTHGSLQteefVKKQQPNGHSPVFAIELDSE-ENAKAFPS 317
Cdd:PRK08249 255 GMKTLKLRVRQQQESAMALAKYL-QTHPKveavyYPGLE--THPNHE----IAKAQMRGFGGILSFVLKGGmDTVKRLLP 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2696122183 318 KLKYFHHATSLGGVESLI-EWRAMSDSSCSPK----------LLRVSVGIENVKDLIADFQQALDTL 373
Cdd:PRK08249 328 KLRYAHRAANLGAVETIYgPARTTSHVENTLEeraalgipegLVRISVGIEDTEDLIADLEQAFAHL 394
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
21-370 |
7.60e-59 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 195.50 E-value: 7.60e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 21 VVTPINVATTYKYNDENLTKLADldlstdyfrtpvYSRLSHPNSEQVEELIGSITD-AHAIAYSSGLGAIFAAFT-HLNP 98
Cdd:PRK08045 23 VVPPIHLSSTYNFTGFNEPRAHD------------YSRRGNPTRDVVQRALAELEGgAGAVLTNTGMSAIHLVTTvFLKP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 99 SK--VAIGKGYHGTHGIADLFTRiKGLTQISINDDLNQLG-------KDDVIFLETPVNPDGEVFDIQYYADIAHSKGAK 169
Cdd:PRK08045 91 GDllVAPHDCYGGSYRLFDSLAK-RGCYRVLFVDQGDEQAlraalaeKPKLVLVESPSNPLLRVVDIAKICHLAREAGAV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 170 LVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPkakfELVSDRVYLGTNI----ANLESFLLIRSL 245
Cdd:PRK08045 170 SVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDP----DVVTELAWWANNIgvtgGAFDSYLLLRGL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 246 RTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSL---QTEEFVKKQQpNGHSPVFAIELDSEENA-KAFPSKLKY 321
Cdd:PRK08045 246 RTLVPRMELAQRNAQAIVKYL----QTQPLVKKLYHPSLpenQGHEIAARQQ-KGFGAMLSFELDGDEQTlRRFLGGLSL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 322 FHHATSLGGVESLIEWRA-MSDSSCSPK----------LLRVSVGIENVKDLIADFQQAL 370
Cdd:PRK08045 321 FTLAESLGGVESLISHAAtMTHAGMAPEaraaagisetLLRISTGIEDGEDLIADLENGF 380
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
2-373 |
8.19e-58 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 192.42 E-value: 8.19e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 2 TGISTNLIHAADGQSRVTDVVT-PINVATTYKYNDENLTKLADldlstdyfrtpvYSRLSHPNSEQVEELIGSITD-AHA 79
Cdd:PRK06176 1 MRMQTKLIHGGISEDTTTGAVSvPIYQTSTYRQDAIGRPKGYE------------YSRSGNPTRFALEELIADLEGgVKG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 80 IAYSSGLGAIFAAFTHLNPSK-VAIGKG-YHGTHGIADLFTRIKGLTQISIN-DDLNQLGK-----DDVIFLETPVNPDG 151
Cdd:PRK06176 69 FAFASGLAGIHAVFSLFQSGDhVLLGDDvYGGTFRLFDKVLVKNGLSCTIIDtSDLSQIKKaikpnTKALYLETPSNPLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 152 EVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAKFELVSDRVYLGT 231
Cdd:PRK06176 149 KITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 232 NIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQTEEF--VKKQQPNGHSPVFAIELDSE 309
Cdd:PRK06176 229 VLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFL----EKHPKVEKVYYPGLPTHPNheLAKKQMRGFSGMLSFTLKND 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2696122183 310 ENAKAFPSKLKYFHHATSLGGVESLIEWRAMSDSSCSPK-----------LLRVSVGIENVKDLIADFQQALDTL 373
Cdd:PRK06176 305 SEAVAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKeqreaagirdgLVRLSVGIEHEQDLLEDLEQAFAKI 379
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
3-371 |
1.63e-55 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 187.54 E-value: 1.63e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 3 GISTNLIHAadGQSR--VTD-VVTPINVATTYKYND----ENLTKLADLDlstdyfrtPVYSRLSHPNSEQVEELIGSIT 75
Cdd:COG2873 7 GFETLALHA--GQEPdpTTGaRAVPIYQTTSYVFDDaehaADLFALKEPG--------NIYTRIMNPTTDVLEKRIAALE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 76 D-AHAIAYSSGLGAIFAAFT-------HLnpskVAIGKGYHGTHgiaDLFTRIkgLTQISIN------DDLNQLGK--DD 139
Cdd:COG2873 77 GgVAALATASGQAAITLAILnlaeagdHI----VASSSLYGGTY---NLFAHT--LPRLGIEvrfvdpDDPEAFEAaiDP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 140 ---VIFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILL---- 212
Cdd:COG2873 148 ntkAIFGETIGNPALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVdggn 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 213 -------------TKDP------------------KAKFELVSDrvyLGTNIANLESFLLIRSLRTYELRILQQSRNATE 261
Cdd:COG2873 228 fdwaangkfpeltEPDPsyhglvyteafgnaafitKARVQLLRD---LGAALSPFNAFLLLQGLETLSLRMERHVENALK 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 262 IVEFLsknrEKYPNITKITHGSLQ---TEEFVKKQQPNGHSPVFAIELD-SEENAKAFPSKLKYFHHATSLGGVESLI-- 335
Cdd:COG2873 305 VAEFL----EAHPKVAWVNYPGLPshpYHELAQKYLPKGAGGVLTFGLKgGREAGKKFIDSLKLFSHLANIGDAKSLVih 380
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 2696122183 336 ------------EWRAmsdSSCSPKLLRVSVGIENVKDLIADFQQALD 371
Cdd:COG2873 381 pastthsqlseeEQAA---AGVTPDLIRLSVGIEDIDDIIADLDQALA 425
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
4-371 |
3.21e-55 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 186.13 E-value: 3.21e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 4 ISTNLIHAADGQSRVTDVV-TPINVATTYKYNDenltkladldlsTDYFRTPVYSRLSHPNSEQVEELIGSITDA-HAIA 81
Cdd:PRK08064 7 IDTLLLHNQYKHDKQTGAVnVPIYHASTFHQFD------------FDTFGKYDYSRSGNPTREALEDIIAELEGGtKGFA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 82 YSSGLGAIFAAFTHLnpSK---VAIGKG-YHGTHG-IADLFTRIkGLTQISIN-DDLNQLGKD-----DVIFLETPVNPD 150
Cdd:PRK08064 75 FASGMAAISTAFLLL--SKgdhVLISEDvYGGTYRmITEVLSRF-GIEHTFVDmTNLEEVAQNikpntKLFYVETPSNPL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 151 GEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAKFELVSDRVYLG 230
Cdd:PRK08064 152 LKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 231 TNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQTEE--FVKKQQPNGHSPVFAIELDS 308
Cdd:PRK08064 232 AVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYL----QEHPKVQNVYYPGLQTHLgfDIQQSQATSAGAVLSFTLQS 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2696122183 309 EENAKAFPSKLKYFHHATSLGGVESLIEWRAMSDSSCSPK-----------LLRVSVGIENVKDLIADFQQALD 371
Cdd:PRK08064 308 EEAVRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKeerdergitdgLLRLSVGLENVDDLIADFEQALS 381
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
2-371 |
1.78e-54 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 184.62 E-value: 1.78e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 2 TGISTNLIHAA-DGQSRVTDVVTPINVATTYKYNDENLTKLADLDLSTDYFrtpvYSRLSHPNSEQVEELIGSITDAHA- 79
Cdd:PRK07503 8 TGFSTRAIHHGyDPLDHGGALVPPVYLTATFAFPTAEYGAECFAGEEEGHF----YSRISNPTLALLEQRMASLEGGEAa 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 80 IAYSSGLGAIFAAF-THLNP-SKVAIGKGYHG------THGIADLFTRIkglTQISINDDLNQLG----KDDVIFLETPV 147
Cdd:PRK07503 84 VALASGMGAITATLwTLLRPgDEVIVDQTLYGctfaflHHGLGEFGVTV---RHVDLTDPAALKAaisdKTRMVYFETPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 148 NPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLT-KDPKAKFELVSDR 226
Cdd:PRK07503 161 NPNMRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGgKALADRIRLEGLK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 227 VYLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQT---EEFVKKQ--QPNGhspV 301
Cdd:PRK07503 241 DMTGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWL----ARHPAVELVHYPGLPSfaqHALAQRQmaLPGG---M 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 302 FAIELDSEENA-KAFPSKLKYFHHATSLGGVESLIEWRA-MSDSSCSPK----------LLRVSVGIENVKDLIADFQQA 369
Cdd:PRK07503 314 IAFELKGGIAAgRRFMNALQLFARAVSLGDAESLAQHPAsMTHSTYTPEeraehgisegLVRLSVGLEDVADILADLAQA 393
|
..
gi 2696122183 370 LD 371
Cdd:PRK07503 394 LD 395
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
54-373 |
1.96e-54 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 183.27 E-value: 1.96e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 54 PVYSRLSHPNSEQVEELIGSITDAHAIAYSSGLGAIFAA-FTHLNPSKVAI--GKGYHGTHGIADLFTRIKGLTQISI-- 128
Cdd:PRK07582 43 DTYGRASNPTWRALEAALGELEGAEALVFPSGMAAITAVlRALLRPGDTVVvpADGYYQVRALAREYLAPLGVTVREApt 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 129 -NDDLNQLGKDDVIFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLL 207
Cdd:PRK07582 123 aGMAEAALAGADLVLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 208 AGILLTKDPKAKFELVSDRVYLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLSKNRE----KYPNI-TKITHG 282
Cdd:PRK07582 203 LGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAvrgvRYPGLpGDPAHE 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 283 slqteefVKKQQPNGHSPVFAIELDSEENAKAFPSKLKYFHHATSLGGVESLIEWRAMSDSSCSPKLLRVSVGIENVKDL 362
Cdd:PRK07582 283 -------VAARQMRRFGGLVSFELADAAAAERFVAASRLVVAATSFGGVHTSADRRARWGDAVPEGFVRLSCGIEDTDDL 355
|
330
....*....|.
gi 2696122183 363 IADFQQALDTL 373
Cdd:PRK07582 356 VADLERALDAL 366
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
3-371 |
3.90e-54 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 183.18 E-value: 3.90e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 3 GISTNLIHAADGQ-SRVTDVVTPINVATTYKYndENLTKLADLDLSTDyfRTPVYSRLSHPNSEQVEELIGSITDA-HAI 80
Cdd:PRK06434 8 GFNTRAVQSGELRdPRFGNVTTPIFETSTFVY--PNSEKEAYMDSTRG--MPYIYTRWGNPTVQAFEEKYAVLENAeHAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 81 AYSSGLGAIFAAFTHL-NPSK--VAIGKGYHGTHgiaDLFTRIKGLTQISIN----DDLNQLGKD----DVIFLETPVNP 149
Cdd:PRK06434 84 SFSSGMGAITSAILSLiKKGKriLSISDLYGQTF---YFFNKVLKTLGIHVDyidtDRLNSLDFDpsnyDLIYAESITNP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 150 DGEVFDIQYYADIAHskGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAKFELVSDRVYL 229
Cdd:PRK06434 161 TLKVPDIKNVSSFCH--ENDVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 230 GTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLSKNrekyPNITKITHGSLQteefVKKQQPNGHSPVFAIELDSE 309
Cdd:PRK06434 239 GSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDS----KKISNVYYPDTE----IGKKVLRGFGGMLSFELRSM 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2696122183 310 ENAKAFPSKLKYFHHATSLGGVESLIEWRA-MSDSSCSPK----------LLRVSVGIENVKDLIADFQQALD 371
Cdd:PRK06434 311 EDVHKFIRNLEIPMVAASLGGVESLITLPVeTSHSSLSPEererlgisdnLVRFSIGIEDIDDLIKDIENALS 383
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
55-373 |
6.85e-54 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 182.72 E-value: 6.85e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 55 VYSRLSHPNSEQVEELIGSITDAHA-IAYSSGLGAIFAA-FTHLNPSK-VAIGKGYHG------THGIADLFTRIKGLTQ 125
Cdd:PRK06234 57 IYSRLGNPTSTEVENKLALLEGGEAaVVAASGMGAISSSlWSALKAGDhVVASDTLYGctfallNHGLTRYGVEVTFVDT 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 126 ISINDDLNQLGKD-DVIFLETPVNPDGEVFDIQYYADIAHS--KGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGG 202
Cdd:PRK06234 137 SNLEEVRNALKANtKVVYLETPANPTLKVTDIKAISNIAHEnnKECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 203 HSDLLAGILLTKDP---KAKFELVSDRVylGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKI 279
Cdd:PRK06234 217 HGDVIAGFVVGKEEfinQVKLFGIKDMT--GSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFL----ESHPAVEKV 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 280 THGSLQTEEF--VKKQQPNGHSPVFAIELDSE-ENAKAFPSKLKYFHHATSLGGVESLIEWRA-MSDSSCSPK------- 348
Cdd:PRK06234 291 YYPGLESFEYyeLAKKQMSLPGAMISFELKGGvEEGKVVMNNVKLATLAVSLGDAETLIQHPAsMTHSPYTAEerkeagi 370
|
330 340
....*....|....*....|....*...
gi 2696122183 349 ---LLRVSVGIENVKDLIADFQQALDTL 373
Cdd:PRK06234 371 sdgLVRLSVGLEDVDDIIADLKQALDLI 398
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
6-371 |
2.14e-53 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 180.69 E-value: 2.14e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 6 TNLIHAA-DGQSRVTDVVTPINVATTYKynDENLTKladldlSTDYfrtpVYSRLSHPNSEQVEELIGSITDAHA-IAYS 83
Cdd:PRK07671 5 TKLIHGGiIGDPSTGAVSVPIYQVSTYK--QEAVGK------HQGY----EYSRTGNPTRAALEELIAVLEGGHAgFAFG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 84 SGLGAIFAAFTHLNPSK--VAIGKGYHGTHgiaDLFTRIkgLTQISI------NDDLNQLGK-----DDVIFLETPVNPD 150
Cdd:PRK07671 73 SGMAAITAVMMLFSSGDhvILTDDVYGGTY---RVMTKV--LNRFGIehtfvdTSNLEEVEEairpnTKAIYVETPTNPL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 151 GEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAKFELVSDRVYLG 230
Cdd:PRK07671 148 LKITDIKKISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 231 TNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQTE--EFVKKQQPNGHSPVFAIELDS 308
Cdd:PRK07671 228 GILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFL----NNHPAVNKVYYPGLPSHpnHELAKEQANGFGGMISFDVGS 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2696122183 309 EENAKAFPSKLKYFHHATSLGGVESLIEWRA-MSDSSCSPK----------LLRVSVGIENVKDLIADFQQALD 371
Cdd:PRK07671 304 EETANKVLERLQYFTLAESLGAVESLISIPSqMTHASIPADrrkelgitdgLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
6-370 |
2.26e-53 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 181.03 E-value: 2.26e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 6 TNLIHAADGQSRVTDVVTPINVATTYKYNDEnltkladlDLSTDYFRTPVYSRLSHPNSEQVEELIGSITDA-HAIAYSS 84
Cdd:PRK08574 5 TDAVRGYRGSDPYGSLQPPIYLTALFRQEGE--------AYPSDRGFDLKYSREENPTLRPLEEALAKLEGGvDALAFNS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 85 GLGAIFAAF-THLNP-SKVAIGK-GYHGTHGIADLFTRIKGLTQI------SINDDLNQlGKDDVIFLETPVNPDGEVFD 155
Cdd:PRK08574 77 GMAAISTLFfSLLKAgDRVVLPMeAYGTTLRLLKSLEKFGVKVVLaypsteDIIEAIKE-GRTKLVFIETMTNPTLKVID 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 156 IQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAKFELVSDRVYLGTNIAN 235
Cdd:PRK08574 156 VPEVAKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 236 LESFLLIRSLRTYELRILQQSRNATEIVEFLS---KNRE-KYPNITKITHGSLQTEEFVKKQqpngHSPVFAIELD-SEE 310
Cdd:PRK08574 236 FEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSehpKVAEvYYPGLPSDPYHGVAKRLFGKDL----YGGVVSFRVKgGRD 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2696122183 311 NAKAFPSKLKYFHHATSLGGVESLIEWRAMSDSSCSPK-----------LLRVSVGIENVKDLIADFQQAL 370
Cdd:PRK08574 312 AVLKFLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEedrkalgitedLVRLSVGLEDVEDLIEDLDQAL 382
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
4-371 |
3.84e-53 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 180.02 E-value: 3.84e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 4 ISTNLIHAADGQSRVTD-VVTPINVATTYKYndenltklADLDLSTDYfrtpVYSRLSHPNSEQVEELIGSITDA-HAIA 81
Cdd:PRK07269 7 INTILAQAGIKSDEATGaLVTPLHFSTTYQH--------PEFGQSTGF----DYTRTKNPTRAKLEETLAAIESAdYALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 82 YSSGLGAIFAAFTHLnP--SKVAIGKGYHGthGIADLFTRIKGLTQISI------NDDLNQLGKD-DVIFLETPVNPDGE 152
Cdd:PRK07269 75 TSSGMSAIVLAFSVF-PvgSKVVAVRDLYG--GSFRWFNQQEKEGRFHFtyanteEELIAAIEEDtDIVYIETPTNPLMV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 153 VFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAKFELVSDRVYLGTN 232
Cdd:PRK07269 152 EFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 233 IANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHgslqteefvkkqqpNGHSPVFAIELDSEENA 312
Cdd:PRK07269 232 LSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFL----KKSPAVKEVLY--------------TGKGGMISFKVADETRI 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 313 KAFPSKLKYFHHATSLGGVESLIEWRAMSDSSCSPK-----------LLRVSVGIENVKDLIADFQQALD 371
Cdd:PRK07269 294 PHILNSLKVFTFAESLGGVESLITYPTTQTHADIPAevrhsygltddLLRLSIGIEDARDLIADLKQALE 363
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
1-370 |
7.58e-50 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 171.42 E-value: 7.58e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 1 MTGISTNLIHAADGQSRVTDVV-TPINVATTYKYndenltklADLDLSTDYfrtpVYSRLSHPNSEQVEELIGSITDAHA 79
Cdd:PRK08247 2 MSTIETKLAQIGNRSDERTGTVnPPVYFSTAYRH--------EGIGESTGF----DYSRTGNPTRGVLEQAIADLEGGDQ 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 80 -IAYSSGLGAI---FAAFThlNPSKVAIGKG-YHGTHGIADLFTRIKGLTQISIN-DDLNQL-----GKDDVIFLETPVN 148
Cdd:PRK08247 70 gFACSSGMAAIqlvMSLFR--SGDELIVSSDlYGGTYRLFEEHWKKWNVRFVYVNtASLKAIeqaitPNTKAIFIETPTN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 149 PDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDpkakfELVSDRVY 228
Cdd:PRK08247 148 PLMQETDIAAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKG-----QELCERLA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 229 -----LGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLSKNREK----YPNITKITHGSLQTEEFVKKqqpnghs 299
Cdd:PRK08247 223 yyqnaAGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVtdvlYPGRGGMLSFRLQDEEWVNP------- 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 300 pvfaieldseenakaFPSKLKYFHHATSLGGVESLIEWRAMSDSSCSP-----------KLLRVSVGIENVKDLIADFQQ 368
Cdd:PRK08247 296 ---------------FLKSLKLITFAESLGGVESFITYPATQTHADIPeeiriangvcnRLLRFSVGIENVEDLIADLKQ 360
|
..
gi 2696122183 369 AL 370
Cdd:PRK08247 361 AF 362
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
56-372 |
8.20e-50 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 173.68 E-value: 8.20e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 56 YSRLSHPNSEQVEELIGSITDA-HAIAYSSGLGAIfAAFTHLNPSKVAIGKG---YHGTHGIADLFTRIKGLTQISIN-D 130
Cdd:PLN02509 127 YTRSGNPTRDALESLLAKLDKAdRAFCFTSGMAAL-SAVTHLIKNGEEIVAGddvYGGSDRLLSQVVPRSGVVVKRVNtT 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 131 DLNQLG-----KDDVIFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSD 205
Cdd:PLN02509 206 NLDEVAaaigpQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSD 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 206 LLAGILLTKDPKAKFELVSDRVYLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLSknreKYPNITKITHGSLQ 285
Cdd:PLN02509 286 VMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLS----SHPRVKKVYYAGLP 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 286 TE--EFVKKQQPNGHSPVFAIELDSEENAKAFPSKLKYFHHATSLGGVESLIEWRA-MSDSSC----------SPKLLRV 352
Cdd:PLN02509 362 DHpgHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCfMSHASIpaevrearglTEDLVRI 441
|
330 340
....*....|....*....|
gi 2696122183 353 SVGIENVKDLIADFQQALDT 372
Cdd:PLN02509 442 SAGIEDVDDLISDLDIAFRT 461
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
55-373 |
2.43e-49 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 170.41 E-value: 2.43e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 55 VYSRLSHPNSEQVEELIGSITDAH-AIAYSSGLGAIFA---AFTHLNpSKVAIGKGYHG-THGiadLFTRIKGLTQI--- 126
Cdd:PRK06767 54 IYSRLGNPTVKLFEERMAVLEGGEeALAFGSGMAAISAtliGFLKAG-DHIICSNGLYGcTYG---FLEVLEEKFMIths 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 127 -----SINDDLNQLGKDDV-IFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFF 200
Cdd:PRK06767 130 fcdmeTEADIENKIRPNTKlIFVETPINPTMKLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYI 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 201 GGHSDLLAGILLTKDPKAKFELVSDRVYLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsKNREK-----YPN 275
Cdd:PRK06767 210 GGHGDVVAGVTICKTRALAEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFL-KNHDAvegvwYPE 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 276 ItkithgslqteEFVKKQQPNGHSpVFAIELD-SEENAKAFPSKLKYFHHATSLGGVESLIEWRAMSDSSCSP------- 347
Cdd:PRK06767 289 G-----------ELASRQMKRGGG-VISFSIKgGKEETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPaelrqem 356
|
330 340 350
....*....|....*....|....*....|
gi 2696122183 348 ----KLLRVSVGIENVKDLIADFQQALDTL 373
Cdd:PRK06767 357 giydNLIRLSVGLESWEDIVSDLEQALKKI 386
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
2-369 |
1.64e-47 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 165.84 E-value: 1.64e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 2 TGISTNLIHAAdgqsrvtdVVTPINVATTYKYndENLTKLADLDlstdyfrtpvYSRLSHPNSEQVEELIGSI-TDAHAI 80
Cdd:PRK08861 13 TGIESDSQYHA--------VVPPIYLSTNYGF--PAFGEVPKYD----------YTRSGNPNRGLLEQTLSELeSGKGAV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 81 AYSSGLGAI---FAAFTHLNPSKVAIGKGYHGTHgiaDLF-TRI-KGLTQISINDDLNQLG-------KDDVIFLETPVN 148
Cdd:PRK08861 73 VTNCGTSALnlwVSALLGPDDLIVAPHDCYGGTY---RLFnTRAnKGDFKVQFVDQSDAAAldaalakKPKLILLETPSN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 149 PDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAKFELVSDRVY 228
Cdd:PRK08861 150 PLVRVVDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNC 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 229 LGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLSKNrekyPNITKITHGSLQT---EEFVKKQQpNGHSPVFAIE 305
Cdd:PRK08861 230 IGATGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQ----SLVGTIYHPSLPEhpgHEIAKKQQ-SGFGSMLSFE 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2696122183 306 LD-SEENAKAFPSKLKYFHHATSLGGVESLI------EWRAMSDSS-----CSPKLLRVSVGIENVKDLIADFQQA 369
Cdd:PRK08861 305 FAgSFEQLKVFVKALALFSLAESLGGVESLIchpasmTHRAMGEEAlaeagVSQQLLRLSVGLEDAQDLIADLDQA 380
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
55-371 |
2.46e-47 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 166.00 E-value: 2.46e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 55 VYSRLSHPNSEQVEELIGSITDAHAIA-YSSGLGAIFAA-FTHLNPSKVAIGKG--YHGTHG-IADLFTRI--------K 121
Cdd:PRK07049 76 VYSRFNHPNSEIVEDRLAVYEGAESAAlFSSGMSAIATTlLAFVRPGDVILHSQplYGGTETlLAKTFRNFgvgavgfaD 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 122 GLTQISIN---DDLNQLGKDDVIFLETPVNPDGEVFDIQYYADIAHSKGAK------LVIDSTFAPPPLSDPFKFGADLV 192
Cdd:PRK07049 156 GLSEAAIGaaaEAAAAKGRVSLILIETPANPTNSLVDVAAVRRVADAIEARqghrpiIACDNTLLGPVFQKPLEHGADLS 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 193 VHSATKFFGGHSDLLAGILLTKdpKAKFELV-SDRVYLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLSKNre 271
Cdd:PRK07049 236 VYSLTKYVGGHSDLVAGAVLGR--KALIRQVrALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDH-- 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 272 kyPNITKIT-HGSLQTEEFVKK---QQPNGHSPVFAIELD-SEENAKAFPSKLKYFHHATSLGGVESLIEWRA-MSDSSC 345
Cdd:PRK07049 312 --PKVEKLHyLPFLDPDSAYGAvykRQCTGAGSTFSFDIKgGQAAAFRFLNALQIFKLAVSLGGTESLASHPAsMTHSGV 389
|
330 340 350
....*....|....*....|....*....|....*.
gi 2696122183 346 ----------SPKLLRVSVGIENVKDLIADFQQALD 371
Cdd:PRK07049 390 padvrerigvLESTIRLSIGIEHPDDLIADLAQALD 425
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
140-370 |
1.90e-44 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 158.23 E-value: 1.90e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 140 VIFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAK 219
Cdd:PRK08776 148 LVLIETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELH 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 220 FELVSDRVYLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQTE--EFVKKQQPNG 297
Cdd:PRK08776 228 QQLVWWANALGLTGSPFDAFLTLRGLRTLDARLRVHQENADAIAALL----DGHAAVNQVYYPGLASHpgHALAARQQKG 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 298 HSPVFAIELDSEENA-KAFPSKLKYFHHATSLGGVESLIEWRA-MSDSSCSPK----------LLRVSVGIENVKDLIAD 365
Cdd:PRK08776 304 FGAMLSFELEGGEAAvRAFVDGLRYFTLAESLGGVESLIAHPAsMTHAAMTAEaraaagisdgLLRLSVGIESAEDLLID 383
|
....*
gi 2696122183 366 FQQAL 370
Cdd:PRK08776 384 LRAGL 388
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
21-373 |
7.68e-44 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 155.76 E-value: 7.68e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 21 VVTPINVATTYKYNDenltkladldlsTDYFRtpvYSRLSHPNSEQVEELIGSITDAH-AIAYSSGLGAI-FAAFTHLNP 98
Cdd:PRK06460 19 ITTPIYQTTAYHYPE------------GEKYR---YSREANPTVLELTKKIVELENAEmGVAFSSGMGAIsTTALALLKP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 99 -SKVAI-----GKGYHgthgiadLFTRIkgLTQISINDDLNQLGKD-----------DVIFLETPVNPDGEVFDIQYYAD 161
Cdd:PRK06460 84 gNSVLVhrdmfGRSYR-------FFTDY--LKNWGVNVDASNPGSDniiekakskryDVVFVENITNPLLRVVDITELSK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 162 IAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILltkdpKAKFELVSD----RVYLGTNIANLE 237
Cdd:PRK06460 155 VCKENGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLA-----AGYGKLLNVidqmRRTLGTSLDPHA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 238 SFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQTEE--FVKKQQPNGHSPVFAIELD-SEENAKA 314
Cdd:PRK06460 230 AYLTLRGIKTLKIRMDVINRNAEQIAEFL----EGHPKVVKVYYPGLKSHVdyEIARRVLKGFGGVLSFEVNgGQESALK 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 315 FPSKLKYFHHATSLGGVESLIEWRA-MSDSSCSPK----------LLRVSVGIENVKDLIADFQQALDTL 373
Cdd:PRK06460 306 VMKSLKLIIPAQTLGGVNSVISHPAtMSHRTLSLEerkivgitdsLLRLSVGIEDVNDLIEDLDRALSTL 375
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
6-370 |
6.98e-43 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 154.52 E-value: 6.98e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 6 TNLIHAADGQSRVTDV-VTPINVATTYKYND----ENLTKLADldlstdyfrtP--VYSRLSHPNSEQVEELIGSITDA- 77
Cdd:PRK07812 16 TKQIHAGQTPDPATNArALPIYQTTSYTFDDtdhaAALFGLAE----------PgnIYTRIMNPTQDVVEQRIAALEGGv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 78 HAIAYSSGLGAIFAAFTHLNPSK---VAIGKGYHGTHgiaDLF--TRIKGLTQISINDDLNQLGK--------DDVIFLE 144
Cdd:PRK07812 86 AALLLASGQAAETFAILNLAGAGdhiVSSPRLYGGTY---NLFhyTLPKLGIEVSFVEDPDDLDAwraavrpnTKAFFAE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 145 TPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILL------------ 212
Cdd:PRK07812 163 TISNPQIDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVdggtfdwtqgrf 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 213 ----TKDP-----------------KAKFELVSDrvyLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrE 271
Cdd:PRK07812 243 pgftTPDPsyhgvvfaelgppayalKARVQLLRD---LGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFL----E 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 272 KYPNITKITHGSLQTE---EFVKKQQPNGHSPVFAIELDSE-ENAKAFPSKLKYFHHATSLGGVESLIEWRAMSDSS--- 344
Cdd:PRK07812 316 ARDEVASVNYAGLPSSpwyERAKRLAPKGTGAVLSFELAGGvEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSqlt 395
|
410 420 430
....*....|....*....|....*....|....
gi 2696122183 345 --------CSPKLLRVSVGIENVKDLIADFQQAL 370
Cdd:PRK07812 396 peeqlatgVTPGLVRLAVGIEGIDDILADLEAGF 429
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
3-370 |
3.89e-40 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 146.78 E-value: 3.89e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 3 GISTNLIHAADGQSRVTDV-VTPINVATTYKYND-ENLTKLADLDLSTDyfrtpVYSRLSHPNSEQVEELIGSITDAHA- 79
Cdd:PRK05994 7 GFATLAVHAGAQPDPTTGArATPIYQTTSFVFNDaDHAASLFGLQAFGN-----IYTRITNPTNAVLEERVAALEGGTAa 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 80 IAYSSGLGAIFAAF-THLNPSK--VAIGKGYHG-----THGiadlFTRIKGLTQISINDDLNQL-----GKDDVIFLETP 146
Cdd:PRK05994 82 LAVASGHAAQFLVFhTLLQPGDefIAARKLYGGsinqfGHA----FKSFGWQVRWADADDPASFeraitPRTKAIFIESI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 147 VNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILL-------TKDPkaK 219
Cdd:PRK05994 158 ANPGGTVTDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVdggtfdwSKSG--K 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 220 FELVSD-----------------------RVY----LGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLSknreK 272
Cdd:PRK05994 236 YPMLSEprpeyhglvlhetfgnfafaiaaRVLglrdLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLK----G 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 273 YPNITKITHGSLQTE---EFVKKQQPNGHSPVFAIEL-DSEENAKAFPSKLKYFHHATSLGGVESLI------EWRAMSD 342
Cdd:PRK05994 312 HPKVSWVNYAGLPDDpyhALAQKYSPKGAGAVFTFGLkGGYEAGVKLVSSLKLFSHLANIGDTRSLVihpastTHRQLTD 391
|
410 420 430
....*....|....*....|....*....|...
gi 2696122183 343 -----SSCSPKLLRVSVGIENVKDLIADFQQAL 370
Cdd:PRK05994 392 eqkvaAGAGPDVVRLSIGIEDVDDIIADLEQAL 424
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
55-370 |
5.02e-39 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 144.22 E-value: 5.02e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 55 VYSRLSHPNSEQVEELIGSITD-AHAIAYSSGLGAIFAAFTHLNPSK---VAIGKGYHGTHGIADLFTRIKGLTQISIN- 129
Cdd:PRK08248 57 IYTRIMNPTTDVFEKRIAALEGgIGALAVSSGQAAITYSILNIASAGdeiVSSSSLYGGTYNLFAHTLPKLGITVKFVDp 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 130 DDLNQL-----GKDDVIFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHS 204
Cdd:PRK08248 137 SDPENFeaaitDKTKALFAETIGNPKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 205 DLLAGI-----------------LLTKDP------------------KAKFELVSDrvyLGTNIANLESFLLIRSLRTYE 249
Cdd:PRK08248 217 TSIGGVivdsgkfdwkgsgkfpgLTEPDPsyhglvytdavgeaayitKARVQLLRD---LGAALSPFNSFLLLQGLETLH 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 250 LRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQTE---EFVKKQQPNGHSPVFAIELD-SEENAKAFPSKLKYFHHA 325
Cdd:PRK08248 294 LRMERHSENALAVAKFL----EEHEAVEWVSYPGLPSHpsyELAKKYLPKGQGAILTFGIKgGVEAGKKLIDSVKLFSHL 369
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2696122183 326 TSLGGVESLIEWRAMS-----------DSSCSPKLLRVSVGIENVKDLIADFQQAL 370
Cdd:PRK08248 370 ANVGDSKSLIIHPASTthqqlseeeqlAAGVTPGLVRLSVGTEAIDDILDDLRQAI 425
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
21-371 |
2.03e-38 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 142.35 E-value: 2.03e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 21 VVTPINVATTYKYND-ENLTKLADLDLSTDyfrtpVYSRLSHPNSEQVEELIGSITDA-HAIAYSSGLGAIFAAFTHLNP 98
Cdd:PRK06084 21 VAVPIYQTTSYAFDDtQHGADLFDLKVPGN-----IYTRIMNPTNDVLEQRVAALEGGvGALAVASGMAAITYAIQTIAE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 99 SK---VAIGKGYHGTHGI-ADLFTRIKGLTQISINDDLNQL-----GKDDVIFLETPVNPDGEVFDIQYYADIAHSKGAK 169
Cdd:PRK06084 96 AGdniVSVAKLYGGTYNLlAHTLPRIGIETRFAAHDDIAALealidERTKAVFCESIGNPAGNIIDIQALADAAHRHGVP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 170 LVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLT------KDPKAKFELVS--DRVYLGTN--------- 232
Cdd:PRK06084 176 LIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDsgkfpwAEHKERFALLNtpDPSYHGVTyteafgpaa 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 233 ----------------IANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQTE-EFVKKQQP 295
Cdd:PRK06084 256 figrcrvvplrnmgaaLSPFNAFLILQGLETLALRMERHTENALKVARYL----QQHPQVAWVKYAGLPDHpEHELARRY 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 296 NGHSPV----FAIELDSEENAKaFPSKLKYFHHATSLGGVESL------IEWRAMSD-----SSCSPKLLRVSVGIENVK 360
Cdd:PRK06084 332 MGGKPAsilsFGIKGGQAAGAR-FIDALKLVVRLVNIGDAKSLachpasTTHRQLNDeelekAGVSRDMVRLSIGIEHID 410
|
410
....*....|.
gi 2696122183 361 DLIADFQQALD 371
Cdd:PRK06084 411 DIIADLAQALD 421
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
52-370 |
5.60e-38 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 140.22 E-value: 5.60e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 52 RTPVYSRLSHPNSEQVEELIGSITDAH-AIAYSSGLGAIFA---AFTHLNPSKVAIGKGYHGTHgiaDLFTRIKGLTQIS 127
Cdd:PRK05968 53 VRPIYSRGDNPTVRAFEEMLAKLEGAEdARGFASGMAAISStvlSFVEPGDRIVAVRHVYPDAF---RLFETILKRMGVE 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 128 IN--------DDLNQLGKDDVIFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKF 199
Cdd:PRK05968 130 VDyvdgrdeeAVAKALPGAKLLYLESPTSWVFELQDVAALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKY 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 200 FGGHSDLLAGILLTkdPKAKFELVSDRV--YLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNIT 277
Cdd:PRK05968 210 LGGHSDTVAGVVAG--SKEHIARINAEAypYLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRL----KAHPVVE 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 278 KITHGSLQTEefvKKQQPNGHSPVFAIELDSEENAKAFPSKLKYFHHATSLGGVESLI-------EWRAMSDS----SCS 346
Cdd:PRK05968 284 RVCHPALANH---PPAGLSGTSGLFSFIFREGIDVRAFADALKLFRLGVSWGGHESLVvpaevvlQQKAQPNSaarfGVS 360
|
330 340
....*....|....*....|....
gi 2696122183 347 PKLLRVSVGIENVKDLIADFQQAL 370
Cdd:PRK05968 361 PRSVRLHVGLEGTEALWADLEQAL 384
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
55-371 |
3.43e-37 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 138.21 E-value: 3.43e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 55 VYSRLSHPNSEQVEELIGSITDAHA-IAYSSGLGAIFA-------AFTHLNPSKVAIGKgyhgthgIADLFTRIkgLTQI 126
Cdd:PRK08133 54 IYSRFTNPTVTMFQERLAALEGAEAcVATASGMAAILAvvmallqAGDHVVSSRSLFGS-------TVSLFEKI--FARF 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 127 SINDDLNQLGKDD-----------VIFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHS 195
Cdd:PRK08133 125 GIETTFVDLTDLDawraavrpntkLFFLETPSNPLTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHS 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 196 ATKFFGGHSDLLAGILLTKDpkakfELVsDRVY-----LGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknr 270
Cdd:PRK08133 205 ATKYLDGQGRVLGGAVVGSK-----ELM-EEVFgflrtAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWL---- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 271 EKYPNITKITHGSLQTE---EFVKKQQPNGHSPVfAIELDS-EENAKAFPSKLKYFHHATSLGGVESLI----------- 335
Cdd:PRK08133 275 EAHPGVERVFYPGLPSHpqhELAKRQQKGGGAIV-SFEVKGgREAAWRVIDATRLISITANLGDTKTTIthpattthgrl 353
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2696122183 336 --EWRA---MSDSscspkLLRVSVGIENVKDLIADFQQALD 371
Cdd:PRK08133 354 spEARAaagITEG-----LIRVAVGLEDVADIKADLARGLA 389
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
23-370 |
1.73e-36 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 137.18 E-value: 1.73e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 23 TPINVATTYKYND-ENLTKLADLDLSTDyfrtpVYSRLSHPNSEQVEELIGSITD-AHAIAYSSGLGAIFAAFTHLNPSK 100
Cdd:PRK08134 29 VPIHLTTSFVFRDsDHAAALFNLERAGH-----VYSRISNPTVAVLEERVAALEGgVGAIATASGQAALHLAIATLMGAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 101 ---VAIGKGYHGTH----------GIADLFTRIKGL----TQISINDDLnqlgkddvIFLETPVNPDGEVFDIQYYADIA 163
Cdd:PRK08134 104 shiVASSALYGGSHnllhytlrrfGIETTFVKPGDIdgwrAAIRPNTRL--------LFGETLGNPGLEVLDIPTVAAIA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 164 HSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGIL----------------LT-------------K 214
Cdd:PRK08134 176 HEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLvdggrfdweasgkfpeLTepyagfhgmvfaeE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 215 DPKAKFELVSDRVYL---GTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLSKNrekyPNITKITHGSLQTE---E 288
Cdd:PRK08134 256 STVAAFLLRARREGLrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASH----PAVARVAHPELESHpdhA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 289 FVKKQQPNGHSPVFAIELD-SEENAKAFPSKLKYFHHATSLGGVESLI-----------EWRAMSDSSCSPKLLRVSVGI 356
Cdd:PRK08134 332 LAKRLLPRGAGSVFSFDLKgGRAAGRKFIESLKLFSHLANVGDARSLVihpastthfrmDAAALAAAGIGEGTIRLSIGL 411
|
410
....*....|....
gi 2696122183 357 ENVKDLIADFQQAL 370
Cdd:PRK08134 412 EDADDLIDDLKRAL 425
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
3-373 |
9.24e-36 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 135.38 E-value: 9.24e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 3 GISTNLIHAadGQSRVTDVVT---PINVATTYKYNDENLTK----LADLDlstdyfrtPVYSRLSHPNSEQVEELIGSIT 75
Cdd:PRK05613 13 GFETRSIHA--GQSVDSDTSArnlPIYQTTSYVFDSAEHAKqrfaLEDLG--------PIYSRLTNPTVEALENRIASLE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 76 D-AHAIAYSSGLGAIFAAFTHLNPSkvaigkgyhGTHGIADlfTRIKGLTQISINDDLNQLGKDdVIFLETP-------- 146
Cdd:PRK05613 83 GgVHAVAFASGQAAETAAILNLAGA---------GDHIVTS--PRLYGGTETLFLVTLNRLGIE-VTFVENPddpeswqa 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 147 --------------VNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILL 212
Cdd:PRK05613 151 avqpntkaffgetfANPQADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 213 ---------------------TKDP-----------------KAKFELVSDRvylGTNIANLESFLLIRSLRTYELRILQ 254
Cdd:PRK05613 231 dggkfdwtverdgkpvfpyfvTPDPayhglkyadlgapafglKARAGLLRDT---GATLSPFNAWVTAQGLDTLSLRLER 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 255 QSRNATEIVEFLsknrEKYPNITKITHGSLQTEEFVKKQQPNGHS---PVFAIELD-SEENAKAFPSKLKYFHHATSLGG 330
Cdd:PRK05613 308 HNENAIKVAEFL----NNHEKVAKVNFAGLKDSPWYATKEKLGLKytgSVLSFDIKgGKDEAWAFIDALKLHSNLANIGD 383
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 2696122183 331 VESLI-----------EWRAMSDSSCSPKLLRVSVGIENVKDLIADFQQALDTL 373
Cdd:PRK05613 384 VRSLVvhpattthsqsDEAGLARAGITQATVRLSVGIEDIDDIIADLEGGFAAI 437
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
55-370 |
9.28e-36 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 134.48 E-value: 9.28e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 55 VYSRLSHPNSEQVEELIGSITDAHA-IAYSSGLGAIFAAFTHL--NPSKVAIGKGYHGTHGIA--DLFTRIKGLTQISIN 129
Cdd:PRK07810 63 VYSRYGNPTVSMFEERLRLIEGAEAcFATASGMSAVFTALGALlgAGDRLVAARSLFGSCFVVcnEILPRWGVETVFVDG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 130 DDLNQLGK-----DDVIFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHS 204
Cdd:PRK07810 143 EDLSQWEEalsvpTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQG 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 205 DLLAGILLtkdpkAKFELVSDRV-----YLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKI 279
Cdd:PRK07810 223 RVLGGAIL-----GDREYIDGPVqklmrHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFL----EGHPAVRWV 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 280 THGSLQTE---EFVKKQQPNGHSpVFAIELD-SEENAK----AFPSKLKYFHHATSLGGVESLI-------------EWR 338
Cdd:PRK07810 294 RYPFLPSHpqyDLAKRQMSGGGT-VVTFELDaPEDAAKkrafEVLDKLRVIDISNNLGDAKSLIthpattthramgpEGR 372
|
330 340 350
....*....|....*....|....*....|....*
gi 2696122183 339 A---MSDSscspkLLRVSVGIENVKDLIADFQQAL 370
Cdd:PRK07810 373 AaigLGDG-----VVRLSVGLEDTDDLIADLDRAL 402
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
55-372 |
1.81e-34 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 131.03 E-value: 1.81e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 55 VYSRLSHPNSEQVEELIGSITDAH-AIAYSSGLGAIFAAFthLNPSK----VAIGKGYHGT--HGIADLFTRIKGLTQIS 127
Cdd:PRK07504 58 IYSRYSNPTVDMFEKRMCALEGAEdARATASGMAAVTAAI--LCQVKagdhVVAARALFGScrYVVETLLPRYGIESTLV 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 128 INDDLNQLGK-----DDVIFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGG 202
Cdd:PRK07504 136 DGLDLDNWEKavrpnTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDG 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 203 HSDLLAGILLTKDPKAKFELVSDRVYLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLSKNrekyPNITKITHG 282
Cdd:PRK07504 216 QGRCLGGVVLSDKAWIEEHLQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGH----PKVARVIYP 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 283 SLQTE---EFVKKQQPNGhSPVFAIELD-SEENAKAFPSKLKYFHHATSLGGVESLI-------------EWRAmsDSSC 345
Cdd:PRK07504 292 GRADHpqaDIIAKQMTGG-STLVAFELKgGKEAAFRFLNALKIVRISNNLGDAKSLIthpattthknlspEARA--ELGI 368
|
330 340
....*....|....*....|....*..
gi 2696122183 346 SPKLLRVSVGIENVKDLIADFQQALDT 372
Cdd:PRK07504 369 SEGFLRLSAGLEDTDDLIEDLAAALKK 395
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
25-356 |
3.74e-32 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 125.26 E-value: 3.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 25 INVATTYKY-NDENLTKL--ADLDLSTDYFrtpVYSRLSHPNSEQVEELIGSITDAHAiAY--SSGLGAIFAAFTHLNPS 99
Cdd:PLN02242 39 IEASATFTVmEPDTMRRMfsGELGPDRDFY---IYSRHFNPTVLNLGRQMAALEGTEA-AYctASGMSAISSVLLQLCSS 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 100 K---VAIGKGYHGTHGI-ADLFTRIKGLTQISIN-DDLN------QLGKDDVIFLETPVNPDGEVFDIQYYADIAHSKGA 168
Cdd:PLN02242 115 GghvVASNTLYGGTHALlAHFLPRKCNITTTFVDiTDLEavkkavVPGKTKVLYFESISNPTLTVADIPELARIAHEKGV 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 169 KLVIDSTFAPPPLSdPFKFGADLVVHSATKFFGGHSDLLAG--------------------ILL--TKDPKAKFELvSDR 226
Cdd:PLN02242 195 TVVVDNTFAPMVLS-PARLGADVVVHSISKFISGGADIIAGavcgpaelvnsmmdlhhgalMLLgpTMNPKVAFEL-SER 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 227 vylgtnIANLesfllirslrtyELRILQQSRNATEIVEFLSKNREK--YPNITKITHGSLqteefVKKQQPNGH--SPVF 302
Cdd:PLN02242 273 ------LPHL------------SLRMKEHCRRAMEYAKRMKELGLKviYPGLEDHPQHAL-----LKSMANKGYgfGGLL 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2696122183 303 AIELDSEENAKAFPSKLKYFHH----ATSLGGVESLIEWRAMSDSS-----------CSPKLLRVSVGI 356
Cdd:PLN02242 330 CLDMDTEERANRLMRYLQNSTQfgfmAVSLGYYETLMSCSGSSTSSeldpeekaaagISPGLVRMSVGY 398
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
65-370 |
2.54e-28 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 114.14 E-value: 2.54e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 65 EQVEELIGSitdAHAIAYSSGLGAI---FAAFTHLNPSKVAIGKGYHGTHGIADLFTRIKGLT----QISINDDLNQLGK 137
Cdd:PRK05967 71 KAIDALEGS---AGTILVPSGLAAVtvpFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEveyyDPEIGAGIAKLMR 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 138 DD--VIFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGIlLTKD 215
Cdd:PRK05967 148 PNtkVVHTEAPGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGT-VSAN 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 216 PKAKFELVSDRVYLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQT--EEFVKKQ 293
Cdd:PRK05967 227 EKCWPQLLEAHGTLGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWL----EGRPDVARVLHPALPSfpGHEIWKR 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 294 QPNGHSPVFAIELDSEE-----NAKAFPSKLKYFHHATSLGGVESLIEWRAMSDSSCS--PK---LLRVSVGIENVKDLI 363
Cdd:PRK05967 303 DFSGASGIFSFVLAAGPekgkaKAHAFLDALEIFGLGYSWGGYESLALHVKLGDRTVAkaPYagpVIRLQIGLEDVPDLK 382
|
....*..
gi 2696122183 364 ADFQQAL 370
Cdd:PRK05967 383 ADLERGF 389
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
22-373 |
2.72e-28 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 114.05 E-value: 2.72e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 22 VTPINVATTYKYndENLTKLADLDL-STDYFRtpvYSRLSHPNSEQVEELIGSITDA-HAIAYSSGLGAI----FA---A 92
Cdd:PRK07050 29 VTPVARASTVVF--PDLATMRALDWrQDVQWR---YGLHATPTSLALAQRLAEIEGGrHALLQPSGLAAIslvyFGlvkA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 93 FTH-LNPSKVaigkgYHGTHGIADLFTRIKGLT----QISINDDLNQLGKDD--VIFLETPVNPDGEVFDIQYYADIAHS 165
Cdd:PRK07050 104 GDDvLIPDNA-----YGPNRDHGEWLARDFGITvrfyDPLIGAGIADLIQPNtrLIWLEAPGSVTMEVPDVPAITAAARA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 166 KGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTKDPKAKFELVSDRVYLGTNIANLESFLLIRSL 245
Cdd:PRK07050 179 RGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIGVSADDCSLVLRGL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 246 RTYELRILQQSRNATEIVEFLsKNRekyPNITKITHGSLQT----EEFvkKQQPNGHSPVFAIELDSE---ENAKAFPSK 318
Cdd:PRK07050 259 PSLQVRLAAHDRSALEVAEWL-KAR---PEIATVLHPALPDcpghAFW--MRDFTGAGGLFSVVFDERyspAQVDAFVEA 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2696122183 319 LKYFHHATSLGGVESLiewrAMSDSSCSPK---------LLRVSVGIENVKDLIADFQQALDTL 373
Cdd:PRK07050 333 LELFAIGWSWGGACSL----AMPYDVASMRtakwphrgtLVRLYIGLEDEADLIADLEQALEAA 392
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
24-373 |
6.69e-28 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 112.86 E-value: 6.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 24 PINVATTYKYNDenLTKLADLdlstdyFRTP----VYSRLSHPNSEQVEELIGSITDAHA-IAYSSGLGAIFAAFT---- 94
Cdd:PRK05939 13 PIHTSVTYGYED--ARDLIDV------FQGKkpgfTYARQGTPTTAALEAKITKMEGGVGtVCFATGMAAIAAVFLtllr 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 95 ---HLNPSKVAIGKgyhgTHgiaDLFTRIKGL-TQISIND--DLNQLgKDDV------IFLETPVNPDGEVFDIQYYADI 162
Cdd:PRK05939 85 agdHLVSSQFLFGN----TN---SLFGTLRGLgVEVTMVDatDVQNV-AAAIrpntrmVFVETIANPGTQVADLAGIGAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 163 AHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILL------------------TKDPKA------ 218
Cdd:PRK05939 157 CRERGLLYVVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTdtglfdwsaypnifpayrKGDPQQwgltqi 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 219 KFELVSDrvyLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQT--EEFVKKQQPN 296
Cdd:PRK05939 237 RKKGLRD---MGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFL----EAHPKVARVYYPGLAShpQHARATELFR 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 297 GHSPVFAIELDSEENAKAFPSKLKYFHHATSLGGVESLI-------------EWRA---MSDSscspkLLRVSVGIENVK 360
Cdd:PRK05939 310 HYGGLLSFELADGIDCFDFLNRLKLVIKATHLGDTRTLVipvaptiyyemgaERRAsmgIADS-----LIRVSVGIEDEA 384
|
410
....*....|...
gi 2696122183 361 DLIADFQQALDTL 373
Cdd:PRK05939 385 DLIADFEQALDAT 397
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
140-371 |
4.07e-27 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 110.59 E-value: 4.07e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 140 VIFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGIlLTKDPKAK 219
Cdd:PRK09028 149 VLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGT-ATANEKHW 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 220 FELVSDRVYLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLsknrEKYPNITKITHGSLQT---EEFVKKQQPN 296
Cdd:PRK09028 228 DQLREHSYLMGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWL----ATRPEVDHVRHPAFETcpgHEFFKRDFSG 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 297 GHSPV-FAIELDSEENAKAFPSKLKYFHHATSLGGVESLI-------EWRAMSDSSCSPKLLRVSVGIENVKDLIADFQQ 368
Cdd:PRK09028 304 SNGLFsFVLKQGDPKAVTALVEGMQHFKMGFSWGGFESLIlgvfginKLRTATNWDFSKPLIRLHIGLEDVDDLIADLEA 383
|
...
gi 2696122183 369 ALD 371
Cdd:PRK09028 384 GFE 386
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
140-365 |
2.36e-20 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 91.30 E-value: 2.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 140 VIFLETPVNPDGEVFDIQYYADIAHSKGAKLVI--DSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGILLTkdpK 217
Cdd:PRK08114 150 VVFLESPGSITMEVHDVPAIVAAVRSVNPDAVImiDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVA---N 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 218 AK-FELVSDRVYLGTNIANLES-FLLIRSLRTYELRILQQSRNATEIVEFLSKNrekyPNITKITHGSLQT---EEFVKK 292
Cdd:PRK08114 227 ARcWEQLRENSYLMGQMVDADTaYMTSRGLRTLGVRLRQHEESSLKVAEWLAEH----PEVARVNHPALPGckgHEFWKR 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 293 QQpNGHSPVFAIELDSEENAKAFPSKLKYFHH---ATSLGGVESLI---------EWRAMSDSSCSPKLLRVSVGIENVK 360
Cdd:PRK08114 303 DF-TGSSGLFSFVLKKKLTDEQLANYLDNFSLfsmAYSWGGFESLIlanqpeeiaAIRPAGEVDFTGTLIRLHIGLEDVD 381
|
....*
gi 2696122183 361 DLIAD 365
Cdd:PRK08114 382 DLIAD 386
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
22-370 |
1.91e-18 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 86.26 E-value: 1.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 22 VTPINVATTYKYN-DENLTKLADLDlSTDYfrtpVYSRLSHPNSEQVEELIGSITDA-HAIAYSSGLGAIFAAFTHLNPS 99
Cdd:PRK06702 25 VLPLYQSTTYKYDtSDDLAALFNLE-AEGY----IYTRIGNPTLAAFEQKLAELEGGvGAVATASGQAAIMLAVLNICSS 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 100 K---VAIGKGYHGTHGIADLFTRIKGLTQISIN-----DDLNQLGKDD--VIFLETPVNPDGEVFDIQYYADIAHSKGAK 169
Cdd:PRK06702 100 GdhlLCSSTVYGGTFNLFGVSLRKLGIDVTFFNpnltaDEIVALANDKtkLVYAESLGNPAMNVLNFKEFSDAAKELEVP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 170 LVIDSTFAPPPLSDPFKFGADLVVHSATKFFGGHSDLLAGI----------------LLTKDP----------------- 216
Cdd:PRK06702 180 FIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIvidggnfdwtngkypeLVEPDPsyhgvsyvqnfgaaayi 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 217 -KAKFELVSDrvyLGTNIANLESFLLIRSLRTYELRILQQSRNATEIVEFLSKNREkypnITKITHGSLQTEE---FVKK 292
Cdd:PRK06702 260 vKARVQLLRD---YGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHER----IEWVNYPGLDSNEnysLAQK 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 293 QQPNGHSPVFAIELDSE-ENAKAFPSKLKYFHHATSLGGVESLI------EWRAMSD-----SSCSPKLLRVSVGIENVK 360
Cdd:PRK06702 333 YLKKGASGVLTFGIKGGlEAAKEFIANVKLATLVTHVADARTCVihpastTHRQLSAedqrlAGVTSDLIRLSVGIEDVS 412
|
410
....*....|
gi 2696122183 361 DLIADFQQAL 370
Cdd:PRK06702 413 DIIADLEAAL 422
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
78-202 |
5.30e-09 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 55.08 E-value: 5.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 78 HAIAYSSGLGAIFAAF-THLNPSKVAIG--KGYHGTHGIADlftRIKGLTQISINDDLNQLGKDDV-------------- 140
Cdd:cd01494 19 KAVFVPSGTGANEAALlALLGPGDEVIVdaNGHGSRYWVAA---ELAGAKPVPVPVDDAGYGGLDVaileelkakpnval 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2696122183 141 IFLETPVNPDGEVFDIQYYADIAHSKGAKLVIDSTFA----PPPLSDPFKFGADLVVHSATKFFGG 202
Cdd:cd01494 96 IVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAggasPAPGVLIPEGGADVVTFSLHKNLGG 161
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
95-215 |
1.93e-04 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 43.09 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 95 HLNPSKVAIGKGYHGTHGIAdlFTRIKGLTQISINDDLNQLGKDDV--IFLETPvNPDGEVFDIQYYADIAHSKGAKLVI 172
Cdd:COG0403 163 DVHPQTRAVLKTYAEPLGIE--VVEVPDEDGVTDLEALKALLDDDVagVLVQYP-NFFGVIEDLRAIAEAAHAAGALVIV 239
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 2696122183 173 --DstfappPLS-----DPFKFGADLVVHSATKF-----FGG-HsdllAGILLTKD 215
Cdd:COG0403 240 aaD------PLSlgllkPPGELGADIVVGEGQRLgvplgFGGpH----AGFFATRE 285
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
88-215 |
4.84e-04 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 41.97 E-value: 4.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 88 AIFAAFTHLNPSKVAIGKGYHgTHGIADLFTRIKGLTQISINDDLNQLGKDDV-----IFLETPvNPDGEVFDIQYYADI 162
Cdd:pfam02347 144 ALAARASKKKGKKFVVDKDVH-PQTLEVLKTRAKPFGIEIVEVDYTEEGVTDLkdvfgVLVQYP-NTDGRIEDYKELIEL 221
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2696122183 163 AHSKGAkLVIDST--FAPPPLSDPFKFGADLVVHSATKF-----FGG-HsdllAGILLTKD 215
Cdd:pfam02347 222 AHQRKS-LVVVAAdlLALTLLKPPGEFGADIAVGSAQRFgvplgYGGpH----AGFFAVKK 277
|
|
| PLN02414 |
PLN02414 |
glycine dehydrogenase (decarboxylating) |
118-208 |
6.61e-04 |
|
glycine dehydrogenase (decarboxylating)
Pssm-ID: 178035 [Multi-domain] Cd Length: 993 Bit Score: 41.67 E-value: 6.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 118 TRIKGLTQISINDDLNQL--GKDDV--IFLETPvNPDGEVFDIQYYADIAHSKGAKLVIDSTF-APPPLSDPFKFGADLV 192
Cdd:PLN02414 211 TRADGLGLEVVVADEKDFdySSGDVcgVLVQYP-ATDGEVLDYAEFVKNAHANGVKVVMATDLlALTMLKPPGEWGADIV 289
|
90 100
....*....|....*....|..
gi 2696122183 193 VHSATKF-----FGG-HSDLLA 208
Cdd:PLN02414 290 VGSAQRFgvpmgYGGpHAAFLA 311
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
100-204 |
2.60e-03 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 39.52 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 100 KVAIGKGYHGTHgIADLFTRIKGLTQISINDDLNQLGKDDVIFLETPVNPD------------GEVFD-IQYYADIAHSK 166
Cdd:cd00613 110 KVLVPDSAHPTN-PAVARTRGEPLGIEVVEVPSDEGGTVDLEALKEEVSEEvaalmvqypntlGVFEDlIKEIADIAHSA 188
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2696122183 167 GAKLVIDStfAPPPLS---DPFKFGADLVVHSATKFFGGHS 204
Cdd:cd00613 189 GALVYVDG--DNLNLTglkPPGEYGADIVVGNLQKTGVPHG 227
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
139-268 |
3.67e-03 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 38.86 E-value: 3.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 139 DVIFLETPVNPDGEVFD---IQYYADIAHSKGAKLVIDSTFA--------PPPLSDPFKFGADLVVHSATKFFGghsdlL 207
Cdd:cd00609 134 KLLYLNNPNNPTGAVLSeeeLEELAELAKKHGILIISDEAYAelvydgepPPALALLDAYERVIVLRSFSKTFG-----L 208
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2696122183 208 AGI----LLTKDPK--AKFELVSDRVYLGTNIANLESFLLIRSLRTYELRILQQS--RNATEIVEFLSK 268
Cdd:cd00609 209 PGLrigyLIAPPEEllERLKKLLPYTTSGPSTLSQAAAAAALDDGEEHLEELRERyrRRRDALLEALKE 277
|
|
| HisC |
COG0079 |
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ... |
139-216 |
9.42e-03 |
|
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 439849 [Multi-domain] Cd Length: 341 Bit Score: 37.80 E-value: 9.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2696122183 139 DVIFLETPVNPDGEVF---DIQYYADiAHSKGAKLVIDST---FAPPPLSdpfkfGADL--------VVHSATKFFG--- 201
Cdd:COG0079 138 DLVFLCNPNNPTGTLLpreELEALLE-ALPADGLVVVDEAyaeFVPEEDS-----ALPLlarypnlvVLRTFSKAYGlag 211
|
90 100
....*....|....*....|..
gi 2696122183 202 -------GHSDLLAGILLTKDP 216
Cdd:COG0079 212 lrlgyaiASPELIAALRRVRGP 233
|
|
| |
