NCBI Conserved Domain Search

Conserved domains on [gi|221360449|emb|CAX16456|]

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tetracycline resistance protein Tet(A), partial [Aeromonas sp. 08111]

Protein Classification

TCR/Tet family MFS transporter( domain architecture ID 13024400)

TCR/Tet family major facilitator superfamily (MFS) transporter functions as a metal-tetracycline/H(+) antiporter that confers tetracycline resistance (TCR) by an active tetracycline efflux

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

MFS_TetA

cd17388

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...

8-292

5.36e-138

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 394.70 E-value: 5.36e-138

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDLV-HSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIR 86
Cdd:cd17388   18 IMPVLPTLLREFVgDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  87 RIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLP 166
Cdd:cd17388   98 RIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLP 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 167 ESHKGERRPLRR-EALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGILHSL 245
Cdd:cd17388  178 ESLPPERRRAFRwRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHAL 257

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 221360449 246 AQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17388  258 FQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILI 304

Name

Accession

Description

Interval

E-value

MFS_TetA

cd17388

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...

8-292

5.36e-138

Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 394.70 E-value: 5.36e-138

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDLV-HSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIR 86
Cdd:cd17388   18 IMPVLPTLLREFVgDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  87 RIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLP 166
Cdd:cd17388   98 RIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLP 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 167 ESHKGERRPLRR-EALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGILHSL 245
Cdd:cd17388  178 ESLPPERRRAFRwRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHAL 257

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 221360449 246 AQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17388  258 FQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILI 304

2_A_01_02

TIGR00880

Multidrug resistance protein;

30-168

1.23e-27

Multidrug resistance protein;

Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 104.27 E-value: 1.23e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   30 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVAG-AYIADIT 108
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221360449  109 DGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSP-HAPFFAAAALNGLNFLTGCFLLPES 168
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGwRAPFLFLAILALAAFILLAFLLPET 141

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

8-292

3.63e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 108.14 E-value: 3.63e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDLVHSndvTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRR 87
Cdd:COG2814   29 VLPALPLIAADLGAS---PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAAR 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  88 IVAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTGCFLL 165
Cdd:COG2814  106 FLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLRLL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 166 PESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQlvgqvpaALWDIFGEDRFHWDATTIGISLAAFGILHSL 245
Cdd:COG2814  186 PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALF-------TYLPLYLQEVLGLSASAAGLLLALFGLGGVL 258

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 221360449 246 AQaMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:COG2814  259 GA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF 304

MFS_1

pfam07690

Major Facilitator Superfamily;

4-281

8.74e-17

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.38 E-value: 8.74e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449    4 ASA*IMPVLPGLLRDLVHSNDVTAhyGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVL 83
Cdd:pfam07690  11 GRSLLGPALPLLLAEDLGISPTEI--GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   84 YIRRIVAGITGATGAVAG-AYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTG 161
Cdd:pfam07690  89 LVLRVLQGLGAGALFPAAlALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  162 CFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALwdIFGEDRFHWDATTIGISLAAFGI 241
Cdd:pfam07690 169 LLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL--PLYQEVLGLSALLAGLLLGLGGL 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 221360449  242 LhSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFA 281
Cdd:pfam07690 247 L-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL 285

PRK09874

multidrug efflux MFS transporter MdtG;

1-141

1.72e-06

multidrug efflux MFS transporter MdtG;

Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 48.76 E-value: 1.72e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   1 TLSASA*IMPVLPGLLRDLvhsnDVTAHY------GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIM 74
Cdd:PRK09874  26 TGAAFSLVMPFLPLYVEQL----GVTGHSalnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLM 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221360449  75 ATAPFLWVLYIRRIVAGITGATGAVAGAYIADITDGDERARHFGFMSAcfgfGMVAGPVLGGLMGGF 141
Cdd:PRK09874 102 GLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLST----GGVSGALLGPLAGGL 164

Name

Accession

Description

Interval

E-value

MFS_TetA

cd17388

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...

8-292

5.36e-138

Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 394.70 E-value: 5.36e-138

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDLV-HSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIR 86
Cdd:cd17388   18 IMPVLPTLLREFVgDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  87 RIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLP 166
Cdd:cd17388   98 RIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLP 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 167 ESHKGERRPLRR-EALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGILHSL 245
Cdd:cd17388  178 ESLPPERRRAFRwRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHAL 257

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 221360449 246 AQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17388  258 FQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILI 304

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

8-292

1.19e-49

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 167.76 E-value: 1.19e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRR 87
Cdd:cd17330   15 VFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLAR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  88 IVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMG-GFSPHAPFFAAAALNGLNFLTGCFLLP 166
Cdd:cd17330   95 FLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLStPYGYALPFLVAAALALLNLVLVLFFLP 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 167 eshkgerrPLRRealnplasfrwargmtvvaaLMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGILHSLA 246
Cdd:cd17330  175 --------PLRR--------------------LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILA 226

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 221360449 247 QAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17330  227 QLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAA 272

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

8-292

3.61e-30

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 116.91 E-value: 3.61e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDLVHSNdvtAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRR 87
Cdd:cd17325   15 IIPILPLYAESLGASV---AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  88 IVAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTGCFLL 165
Cdd:cd17325   92 FLQGLaSAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVLALLLL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 166 PESHKGERRPLRREALNPLASFRWARGMTvVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGILHSL 245
Cdd:cd17325  172 PEPRPPPNKRAVSAARLRSGLRLLLRDRR-LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 221360449 246 AQaMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17325  251 SQ-PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLA 296

MFS_SLC22A18

cd17331

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...

9-292

8.23e-29

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 113.08 E-value: 8.23e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   9 MPVLPGLLRDLVHSNdvtAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRI 88
Cdd:cd17331   20 QPVLPYLTKKLGVDS---VVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  89 VAgITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTGCFLLPE 167
Cdd:cd17331   97 PS-VFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKkFGEQAAALVAAVGSLLSIVLVILLIPS 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 168 SHKGERRPLRRE-ALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPA----ALWDIFGEDRFHWDATTIGISLAAFGIL 242
Cdd:cd17331  176 NTKSKREKEAKEsASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIgmfqSMFSLVAMDFFGLTPEENGYLMSYAGVL 255

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 221360449 243 HSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17331  256 GMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLL 305

2_A_01_02

TIGR00880

Multidrug resistance protein;

30-168

1.23e-27

Multidrug resistance protein;

Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 104.27 E-value: 1.23e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   30 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVAG-AYIADIT 108
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221360449  109 DGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSP-HAPFFAAAALNGLNFLTGCFLLPES 168
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGwRAPFLFLAILALAAFILLAFLLPET 141

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

8-292

3.63e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 108.14 E-value: 3.63e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDLVHSndvTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRR 87
Cdd:COG2814   29 VLPALPLIAADLGAS---PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAAR 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  88 IVAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTGCFLL 165
Cdd:COG2814  106 FLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLRLL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 166 PESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQlvgqvpaALWDIFGEDRFHWDATTIGISLAAFGILHSL 245
Cdd:COG2814  186 PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALF-------TYLPLYLQEVLGLSASAAGLLLALFGLGGVL 258

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 221360449 246 AQaMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:COG2814  259 GA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF 304

MFS_MFSD9

cd17390

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...

8-286

4.52e-26

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 105.00 E-value: 4.52e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDLVHSNDVTahyGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRR 87
Cdd:cd17390   15 ILPLLSTHIRSLGASPTVI---GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  88 IVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGG----LMGGFSPHAPFFAAAALngLNFLTGCF 163
Cdd:cd17390   92 IPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGhlaeTDGGFYYVALLCSAIFI--LNAGLVWF 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 164 LLPEshkgerrplrrealnplasfrwargmtvVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGILH 243
Cdd:cd17390  170 LLSK----------------------------LWDLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLG 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 221360449 244 SLAQAMITGPVAARLGERRALMLGM-IADGTGYILLAFATRGWM 286
Cdd:cd17390  222 ALSGFLVGRILKLYKNNEYLLLLHSfILLALSLLGLALAPSIWL 265

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

10-292

2.03e-19

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 86.86 E-value: 2.03e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  10 PVLPGLLRDLVHSndvTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIV 89
Cdd:cd17474   20 PILPAIAEALGAS---PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  90 AGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPES 168
Cdd:cd17474   97 QGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEP 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 169 HKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVgqvpAALWDIFGEDRFHWDATTIGISLAAFGILHSLAqA 248
Cdd:cd17474  177 KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAF----LTYLPFLLELLYGISPIIIGLLFAGWSVLLALG-S 251

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 221360449 249 MITGP-VAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17474  252 LFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIV 296

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

1-292

9.06e-19

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 85.32 E-value: 9.06e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   1 TLSASA*IMPVLPGLLRDLVHSNDVTAhyGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGaavdYTIMATAPF- 79
Cdd:cd17473   11 TVMAGAAIAPALPAIAQHFVPNSELLV--PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLL----YGIGGVAGLf 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  80 ---LWVLYIRRIVAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSpHAPFFAAAALNG 155
Cdd:cd17473   85 ldsLYALLASRALLGIgVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIG-WRAPFLVYLLAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 156 LNFLTGCFLLPEShKGERRPLRREALNPLASFRWARgmtVVAALMAVFFIMQLVGQVPAALWDIFGEdRFHWDATTIGIS 235
Cdd:cd17473  164 PVLILVLLFLPEP-ARKSKSAASPGAATAAALPWKR---VLPIYFLAFLAMLLFYVIPIQLPFLLQE-RGGGSAALIGLA 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 221360449 236 LAAFGILHSLAqAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17473  239 LAIASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAI 294

MFS_MFSD14

cd17387

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...

30-286

1.51e-18

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 84.78 E-value: 1.51e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  30 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPflWVLYIRRIVAGITGATGAVAGAYIADITD 109
Cdd:cd17387   39 GLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISP--WWYFAMISVSGIFSVTFSVIFAYVADITT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 110 GDERARHFGFMSACFGFGMVAGPVLGG-LMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALN------ 182
Cdd:cd17387  117 EEERSTAYGLVSATFAASLVTSPALGAyLSESYGDNLVVLVATIVALLDICFILLAVPESLPEKMRPASWGAPIsweqad 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 183 PLASFRWARGMTVVAALMAVFFIMQL--VGQ---VPAALWDIFGedrfhWDATTIGISLAAFGILHSLAQAMITGPVAAR 257
Cdd:cd17387  197 PFASLRKVGKDKTVLLICITVFLSYLpeAGQyssFFVYLKQVMG-----FEYEEVAAFIAVVGILSITAQTLLLSILMRS 271

                        250       260
                 ....*....|....*....|....*....
gi 221360449 258 LGERRALMLGMIADGTGYILLAFATRGWM 286
Cdd:cd17387  272 IGAKNTILLGLGFQMLQLAWYGFGSQHWM 300

MFS_MFSD10

cd17389

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...

2-136

4.93e-18

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 83.09 E-value: 4.93e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   2 LSASA*IMPVLPGLL---------------RDLVHS------NDVTAHY------GILLALYALMQFACAPVLGALSDRF 54
Cdd:cd17389   12 LLAFTIILPLFPSLLdyygqnddsglyslqISSVDWfrdaigAPDERRYnsvlfgGLIGSLFSLLQFLSSPITGAASDVY 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  55 GRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVL 134
Cdd:cd17389   92 GRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMI 171


                 ..
gi 221360449 135 GG 136
Cdd:cd17389  172 GA 173

MFS_1

pfam07690

Major Facilitator Superfamily;

4-281

8.74e-17

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.38 E-value: 8.74e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449    4 ASA*IMPVLPGLLRDLVHSNDVTAhyGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVL 83
Cdd:pfam07690  11 GRSLLGPALPLLLAEDLGISPTEI--GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   84 YIRRIVAGITGATGAVAG-AYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTG 161
Cdd:pfam07690  89 LVLRVLQGLGAGALFPAAlALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  162 CFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALwdIFGEDRFHWDATTIGISLAAFGI 241
Cdd:pfam07690 169 LLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL--PLYQEVLGLSALLAGLLLGLGGL 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 221360449  242 LhSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFA 281
Cdd:pfam07690 247 L-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL 285

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

8-288

3.06e-16

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 78.02 E-value: 3.06e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDLVHSNDVTahyGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRR 87
Cdd:cd17489   15 LLPVLPLYAHDLGGSEAVA---GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  88 IVAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLP 166
Cdd:cd17489   92 LIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVK 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 167 EsHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVgqvpAALWDIFGEDRFHWDAttiGISLAAFGILhSLA 246
Cdd:cd17489  172 D-PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAI----STFLPLYAAERGISNA---GLFFTVYAIA-LLL 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 221360449 247 QAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAF 288
Cdd:cd17489  243 SRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLL 284

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

1-292

5.65e-16

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 77.08 E-value: 5.65e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   1 TLSASA*IMPVLPGLLRDLVHSNdvtAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFL 80
Cdd:cd06174    8 TGLARGLISPLLPALLQSFGLSA---SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  81 WVLYIRRIVAGITGA-TGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFL 159
Cdd:cd06174   85 WLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 160 TGCFLL----PESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGIS 235
Cdd:cd06174  165 AAILLLlvvpDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLL 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 221360449 236 LAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd06174  245 LSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL 301

MFS_MdfA_MDR_like

cd17320

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...

8-286

3.09e-15

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 74.92 E-value: 3.09e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDL-VHSNDVTAHYGILLALYALMQFacapVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIR 86
Cdd:cd17320   18 YLPALPAIARDLgASASAVQLTLSAYLLGFALGQL----LYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  87 RIVAGITGATGAV-AGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGG-LMGGFSPHAPFFAAAALNGLNFLTGCFL 164
Cdd:cd17320   94 RFLQGLGAAAGSVvARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGlLLLFFGWRAIFVFLALLGLLLLLLVLLF 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 165 LPESHKGERR-----PLRREALNPLASFRWARGMTVVAALMAVFFIMqlvgqvpAALWDIFGEDRFHWDATTIGISLAAF 239
Cdd:cd17320  174 LPETLPEEKRkpllsSLLRAYKRVLKNRRFLGYALALGLSFAGLFAY-------LAAAPFIYIEQLGLSPAQFGLLFALN 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 221360449 240 GILHSLAqAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWM 286
Cdd:cd17320  247 AIALILG-SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGG 292

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

30-292

6.33e-15

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 74.19 E-value: 6.33e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  30 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVAG-AYIADIT 108
Cdd:cd17329   38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASeAMIADVT 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 109 DGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFR 188
Cdd:cd17329  118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 189 WARgmTVVAALMAVFFIMQLVGQVPAALwDIFGEDRFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGM 268
Cdd:cd17329  198 RDR--AFLLFLLASFLISLIYFQLESTL-PVYVVEILGLGESLLGLLLALNALLIVLLQ-FPVARLVERFRLRKILMIGI 273

                        250       260
                 ....*....|....*....|....
gi 221360449 269 IADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17329  274 LLFAIGFAVLAFANTLAVLILAMI 297

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

14-292

9.38e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 73.35 E-value: 9.38e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  14 GLLRDLVHSNDVTAHY-GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI 92
Cdd:cd17324   20 GLLPDIARDFGVSVAQaGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  93 T-GATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTGCFLLP---E 167
Cdd:cd17324  100 AhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQlLGWRAAFLAIAVLALLAALLLWRLLPslpP 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 168 SHKGERRPLRREAL---NPLASFRWARGMTVVAALMAVFFIMQLvgqvpaalwdiFGEDRFHWDATTIGISLAAFGILhS 244
Cdd:cd17324  180 KKPGSLGLLSSLLLllrNPRLRLAYLITFLLFGGFFALYTYLAP-----------FLTDVPGFSSSAIIGLLLLFGVA-G 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 221360449 245 LAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17324  248 VVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLV 295

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

4-138

7.24e-14

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.07 E-value: 7.24e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   4 ASA*IMPVLPGLLRDLVHSNdvTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVL 83
Cdd:cd17325  214 AFGALEPFLPLYAAELGGLS--PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLL 291

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 221360449  84 YIRRIVAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17325  292 LLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

1-285

5.52e-13

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 68.44 E-value: 5.52e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   1 TLSASA*IMPVLPGLLRDL-VHSNDVTAHY-GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAP 78
Cdd:cd17391    8 TGIGFSLIAPFLPLYIEQLgVTSGGLVELWsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVT 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  79 FLWVLYIRRIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPFFAAAALNGLN 157
Cdd:cd17391   88 NVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADlFGIRNVFFITGGLLFLA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 158 FLTGCFLLPESHKGERrplRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWDIFGED--RFHWDATTI-GI 234
Cdd:cd17391  168 FLLTLFFVKEDFKPVE---KKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQlmGDASNLAFIsGL 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 221360449 235 SLAAFGiLHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGW 285
Cdd:cd17391  245 VFSATG-VSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPW 294

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

30-288

1.72e-12

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.80 E-value: 1.72e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  30 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI-TGATGAVAGAYIADIT 108
Cdd:COG0738   46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLgLGLLDVAANPYVAALG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 109 DgDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFR 188
Cdd:COG0738  126 P-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLK 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 189 WARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGM 268
Cdd:COG0738  205 SLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR-FLGGFLLKRFGPVRLLRLSA 283

                        250       260
                 ....*....|....*....|
gi 221360449 269 IADGTGYILLAFATRGWMAF 288
Cdd:COG0738  284 LLAAVGLLLALLAPGPWLAL 303

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

30-292

2.21e-12

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 66.48 E-value: 2.21e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  30 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPF-----LWVLYIRRIVAGITGATGAVA-GAY 103
Cdd:cd06173   37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALlgslsLWLLLVLAFLLGIASAFFGPArQAL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 104 IADITDGDERARHFGFMSACFGFGMVAGPVLGGLM-GGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALN 182
Cdd:cd06173  117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLvALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRD 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 183 PLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGIlHSLAQAMITGPVAARLGERR 262
Cdd:cd06173  197 LREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV-GALLGALLLGRLSKRRRRGR 275

                        250       260       270
                 ....*....|....*....|....*....|
gi 221360449 263 ALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd06173  276 LLLIGALLLGLALLVLGLSPSLWLLLAALF 305

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

26-270

7.95e-12

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 64.45 E-value: 7.95e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  26 TAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATG-AVAGAYI 104
Cdd:COG0477   48 SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLmPGALALI 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 105 ADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPL 184
Cdd:COG0477  128 AELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 185 ASFRWARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRAL 264
Cdd:COG0477  208 LAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287


                 ....*.
gi 221360449 265 MLGMIA 270
Cdd:COG0477  288 LLLLAL 293

MFS_Azr1_MDR_like

cd17502

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...

36-138

7.98e-12

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 64.51 E-value: 7.98e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  36 YALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGItGATGAVAGAY--IADITDGDER 113
Cdd:cd17502   39 YLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGI-GGGGLMSLAFiiIADLVPPRER 117

                         90       100
                 ....*....|....*....|....*
gi 221360449 114 ARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17502  118 GKYQGYIGAVFGIASVAGPLIGGAF 142

MFS_SLC46

cd17386

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...

15-292

9.05e-12

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 64.61 E-value: 9.05e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  15 LLRDLVHSNDVTAHYGILLALYALMqfaCAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMA------TAPFLWVLYIRRI 88
Cdd:cd17386   21 VTQNFVYAANFYLYMNLMGSIPPLF---SSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVlivyftTVPSVWWFYLSAI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  89 VAGITGATGAVAG---AYIADITDGDERARHFGFMSACFGFGMVAGPVLGG-LMGGFSPHAPFFAAAALNGLNFLTGCFL 164
Cdd:cd17386   98 PLALFGGFTAFLSasfAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGhLFKALGYAWSFSISAALLLIALLYILFF 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 165 LpeshkgerrplrrealnplasfrwargmTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLaAFGILHS 244
Cdd:cd17386  178 L----------------------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFS-TLGSLIY 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 221360449 245 LAQAMITGPVAARLGERRALMLGMIA---DGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17386  229 LTGMLGGVLLLRCLLKMSDSTLAMLGlasHILSSLLFAFATNTWMMYLAAV 279

MFS_MFSD8

cd17326

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...

26-138

1.06e-11

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 64.54 E-value: 1.06e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  26 TAHYGILLALYALMQFACAPVLGALSDRFG-RRPVLLVSLAGAAVDYTI-----MATAPFLWVLYIRRIVAGITGATGAV 99
Cdd:cd17326   35 ASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILyalaeYFPSNRKYVMLVARFLIGVGAGNVAV 114

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 221360449 100 AGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17326  115 LRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAF 153

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

36-292

2.30e-11

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 63.35 E-value: 2.30e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  36 YALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGA-TGAVAGAYIADITDGDERA 114
Cdd:cd17321   40 YLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAaIMPASLALIAATFPGERRG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 115 RHFGFMSACFGFGMVAGPVLGGLMGGFsphapfFAAAALNGLNFLTGCFLLPEShkgerrplRREALNPLASFrwargmT 194
Cdd:cd17321  120 RALGLWGAVVGIGAALGPLLGGLLLEL------FGWRWIFLINVPIGLVALLLA--------RTFSGAVLAAF------L 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 195 VVAALMAVFFIMQLVGQvpaalwdifgeDRFHWDATTIGISLAAFGILhSLAQAMITGPVAARLGERRALMLGMIADGTG 274
Cdd:cd17321  180 LGAALGGLLFLLPLYLQ-----------GVLGYSPLQAGLALLPLALA-MLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247

                        250
                 ....*....|....*...
gi 221360449 275 YILLAFATRGWMAFPIMV 292
Cdd:cd17321  248 LLLLALLGADSSVWLLLP 265

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

26-292

2.93e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 63.36 E-value: 2.93e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  26 TAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATG-AVAGAYI 104
Cdd:COG2223   39 AAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSfAVGIALV 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 105 ADITDGDERARHFGFMSACFGFG-MVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNP 183
Cdd:COG2223  119 SKWFPPDRRGLALGLAAGGGNLGaAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 184 LASFRwargmTVVAALMAVFFIMQLVGQVPAALW-DIFGEDRFHWDATTIGISLAAFGILHSLAQAmITGPVAARLGERR 262
Cdd:COG2223  199 LEALR-----DPRFWLLSLLYFGTFGSFIGFSSWlPPYLVDQFGLSAATAGLLAALFALLGALGRP-LGGWLSDRIGGRR 272

                        250       260       270
                 ....*....|....*....|....*....|
gi 221360449 263 ALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:COG2223  273 VLLIVFALMALGLLLLALALGSLWLFLVLF 302

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

1-141

2.06e-10

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 60.74 E-value: 2.06e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   1 TLSASA*IMPVLPGLLRDLVHSNDVTAHY-GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPF 79
Cdd:cd17391  213 IQLANQSIEPILTLYIRQLMGDASNLAFIsGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQT 292

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221360449  80 LWVLYIRRIVAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGF 141
Cdd:cd17391  293 PWQLGILRFLLGLaTGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAH 355

MFS_Tpo1_MDR_like

cd17323

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...

4-141

5.19e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 59.51 E-value: 5.19e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   4 ASA*IMPVLPGLLRDLvHSNDVTAHYGILLALYAlmqFACAP-VLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWV 82
Cdd:cd17323   14 GSSIYSPALPQIAEDF-HVSEEVANLGVSLFVLG---FGLGPlIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAM 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  83 LYIRRIVAGITGATG-AVAGAYIADITDGDERarhfGFMSACFGFGMVAGPVLGGLMGGF 141
Cdd:cd17323   90 LIILRFLQGFFGSSPlAIGAGTIADLFTPEER----GKAMGVYSLGPLLGPALGPIIGGF 145

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

27-292

7.56e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.15 E-value: 7.56e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  27 AHYGILLALYALMQFACAPVLGALSDRFG-----RRPVLLVSLAGAAVDYTIMATAPF------LWVLYIRRIVAGITGA 95
Cdd:COG2211   46 ALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDlsptgkLIYALVTYLLLGLAYT 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  96 TGAVA-GAYIADIT-DGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLN--FLTGCFLLPESHKG 171
Cdd:COG2211  126 LVNIPySALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFavLGLLAFLLTFFGTK 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 172 ERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGILhSLAQAMIT 251
Cdd:COG2211  206 ERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLA-ALLGAPLW 284

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 221360449 252 GPVAARLGERRALMLGMIADGTGYILLAFATRG--WMAFPIMV 292
Cdd:COG2211  285 PRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGnlWLLLVLAA 327

MFS_YajR_like

cd17472

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...

8-227

2.77e-09

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 57.23 E-value: 2.77e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDLVHSNDVTAhyGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRR 87
Cdd:cd17472   15 VLPVLSVYAKSLPGATPTLI--GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGR 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  88 IVAGItGATGAVAGAYIADITDGDERARHFGFMSACFGF----GMVAGPVLGGLMGgfsPHAPFFAAAALNGLNFLTGCF 163
Cdd:cd17472   93 ALQGS-GAISSVVMALLADLTREENRTKAMALIGASIGIafaiSMVLGPLLAAHLG---VSGLFLITAILSLVSLLILLF 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 164 LLPES--HKGERRPLRREALNPLASFRWAR----GMTVVAALMAVFFImqlvgqVPAALWDIFGEDRFHW 227
Cdd:cd17472  169 FVPDPpkIVQISEKEKKKLKKLLKNKRLLRldfsIFILHFVLMAFFYI------LPLLLTQLGGGKGQLW 232

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

31-138

3.91e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.78 E-value: 3.91e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  31 ILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI-TGATGAVAGAYIADITD 109
Cdd:cd17370  238 LLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLyMGAQESIERAAVADLVP 317

                         90       100
                 ....*....|....*....|....*....
gi 221360449 110 GDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17370  318 AELRGTAYGLFNTVVGIGWLLASLIAGYL 346

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

27-138

4.61e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.42 E-value: 4.61e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  27 AHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI-TGATGAVAGAYIA 105
Cdd:COG2271   45 AQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIA 124

                         90       100       110
                 ....*....|....*....|....*....|...
gi 221360449 106 DITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:COG2271  125 EWFPPKERGRALGIFNAGGPLGGALAPPLLGWL 157

MFS_LmrB_MDR_like

cd17503

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...

45-292

1.15e-08

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 55.27 E-value: 1.15e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  45 PVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGA-VAGAYIADITDGDERarhfGFMSAC 123
Cdd:cd17503   49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKR----GAAMGL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 124 FGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLlpeshkgerrplrreaLNPLASFRWARGMTVVAALMAVF 203
Cdd:cd17503  125 VGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALL----------------LAPLLDLRLFKDRNFTLGLLLSF 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 204 FIMQLVGQVPAALwDIFGEDRFHWDATTIGISLAAFGILHSLAqAMITGPVAARLGERRALMLGMIADGTGYILLAFAT- 282
Cdd:cd17503  189 LLGLGLFGAMFLL-PLYLQNVLGYSAFESGLVLAPGGLASAIL-SPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTp 266

                        250
                 ....*....|...
gi 221360449 283 ---RGWMAFPIMV 292
Cdd:cd17503  267 dtsLWLIILPLFI 279

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

23-141

1.43e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.29 E-value: 1.43e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  23 NDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPF--LWVLYIRRIVAGIT-GATGAV 99
Cdd:COG2211  260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnLWLLLVLAALAGIGlGAILVL 339

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 221360449 100 AGAYIADITDGDERA---RHFGFMSACFGFGMVAGPVLGGLMGGF 141
Cdd:COG2211  340 PWAMLADVVDYDEWKtgrRREGLYFGIFTFAIKLGQALAGALAGL 384

MFS_MMR_MDR_like

cd17504

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...

6-280

2.50e-08

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 54.51 E-value: 2.50e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   6 A*IMPVLPGLLRDLvhsNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYI 85
Cdd:cd17504   13 TMLSPALPTIQREF---GTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  86 RRIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLL 165
Cdd:cd17504   90 GRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 166 PESHKGERRPLrreALNPLAsfrwargMTVVAALMAVFFIMQLVGQVPAALWDIFGedrfhwdATTIGISLAAFGILhSL 245
Cdd:cd17504  170 DLRLLRRRNVL---LANITA-------LLAGFGMFMVFQLLPQLLQLPTPTGFGLG-------ITEAGLLLLPGALV-ML 231

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 221360449 246 AQAMITGPVAARLGERRALMLGMIADGTGYILLAF 280
Cdd:cd17504  232 IAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLAL 266

MFS_Set

cd17471

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...

4-292

7.02e-08

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 52.93 E-value: 7.02e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   4 ASA*IMPVLPGLLRDLVHSNDVTahYGILLALYALMQFACAPVLGALSDR-FGRRPVLLVSLAGAAVDYTIMA-TAPFLW 81
Cdd:cd17471   11 AGAFVLPYLSLFLTEELGASPLQ--IGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAfLRNYWV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  82 VLYIRRIVAGITGATGAVAGAYIADITDGDERARHFGFMS---ACFGFGMVAGPVLGG-LMGGFSPHAPFFAAAALNGLN 157
Cdd:cd17471   89 LLLVGVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNSvlrAAFSLAWVIGPPLAFlLLDVLGFTGLFLLAALLYLVV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 158 FLTGCFLLPEshkgeRRPLRREALNPLASFRWARGMTVVAaLMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISL- 236
Cdd:cd17471  169 ALLVLFLLPS-----VKPPAQKATPASSLVKAPVNRRLLL-LFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFg 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 221360449 237 --AAFGILhslaqAMI-TGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17471  243 laAALEIP-----IMLlAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQL 296

efflux_Bcr_CflA

TIGR00710

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...

9-174

7.44e-08

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.

Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 52.77 E-value: 7.44e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449    9 MPVLPGLLRDLVHSNDVTAHygiLLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRI 88
Cdd:TIGR00710  25 LPAFPEIAADLSTPASIVQM---TLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   89 VAGITGATGAV-AGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNG-LNFLTGCFLLP 166
Cdd:TIGR00710 102 VQAFGASAGSViSQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGiLLSALIFFILP 181


                  ....*...
gi 221360449  167 ESHKGERR 174
Cdd:TIGR00710 182 ETLPYEAR 189

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

27-138

1.72e-07

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.83 E-value: 1.72e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  27 AHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVA-GAYIA 105
Cdd:cd17489  227 SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPAlQALAV 306

                         90       100       110
                 ....*....|....*....|....*....|...
gi 221360449 106 DITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17489  307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV 339

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

11-138

2.93e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.08 E-value: 2.93e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  11 VLPGLLRDLVHSNDVTAHYGILLAL-YALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIV 89
Cdd:cd17328   17 TIAGVLPDIQSDFLIDDSLAGLLQTvFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 221360449  90 AGITGATGA-VAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17328   97 VGIGEASYSpIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLV 146

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

4-281

4.42e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 50.63 E-value: 4.42e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   4 ASA*IMPVLPGLLRDLVHSNDVTahyGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVL 83
Cdd:cd17477   11 GSGLLLPLLSLRLEREGVSTALI---GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVW 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  84 YIRRIVAGITGATGAVAG-AYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMG--GFSPHAPFFAAAALNGLNFLT 160
Cdd:cd17477   88 FLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGtaGALPFLIAAVLLLLALVPLLL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 161 GCFLLPESHKGERRPLRRealnplasFRWARGMTVVAALMAVFFIMQLVGQVPaalwdIFGEdRFHWDATTIGISLAAFG 240
Cdd:cd17477  168 TRRAAPEIEEAESISLRR--------LLRIAPLALLGAFVAGFLEGAFYSLLP-----LYGL-RLGLSVAQAALLLAAFV 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 221360449 241 ILHSLAQAMItGPVAARLGERRALMLGMIADGTGYILLAFA 281
Cdd:cd17477  234 LGGLLLQWPL-GWLADRFDRRRVLLGCALLGALAALLLPLV 273

MFS_SLC46A1_PCFT

cd17449

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...

25-136

6.68e-07

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 50.19 E-value: 6.68e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  25 VTAHY-------GILLALYALMqfacapVLGALSDRFGRRPVLLVSLAG----AAVDYTIMATAPFLWVLYIRRIVAGIT 93
Cdd:cd17449   62 LTAHWnlyinlgGFLVGLFSVT------LLGPWSDSVGRRPVLILPSLGlalqAAVYLLVMYLQLHVAYFLIGRILSGLL 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 221360449  94 GATGAV-AG--AYIADITDGDERARHFGFMSACFGFGMVAGPVLGG 136
Cdd:cd17449  136 GDFNGIlAGcfAYVADVSDRRSRTFRVAVLEACLGLAGMLASIIGG 181

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

30-138

8.34e-07

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.48 E-value: 8.34e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  30 GILLALYALMQFACAPVLGALSDRFGRRPVLLV-SLAGAAVDYTIMATAPFLWVLYIRRIVAG-ITGATGAVAGAYIADI 107
Cdd:cd17477  226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGcALLGALAALLLPLVPGLPLALLVLLFLWGgAAGPLYTLALALAGDR 305

                         90       100       110
                 ....*....|....*....|....*....|.
gi 221360449 108 TDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17477  306 LPGDELVAANAALLLLYGLGSVIGPLLAGAL 336

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

30-138

9.99e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.52 E-value: 9.99e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  30 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI-TGATGAVAGAYIADIT 108
Cdd:cd17316   39 GLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFA 118

                         90       100       110
                 ....*....|....*....|....*....|
gi 221360449 109 DGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17316  119 PSKRRGFALGLLQSGWALGALLAALVASLL 148

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

10-292

1.08e-06

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 49.49 E-value: 1.08e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  10 PVLPGLLRDLVHSNDVTahyGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIV 89
Cdd:COG2807   39 PLLPEIRADLGLSATQA---GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  90 AGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGG-LMGGFSPHAPFFAAAALNGLNFLTGCFLLPES 168
Cdd:COG2807  116 IGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVpLAAALGWRGALAVWALLALLALLLWLPLLRRR 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 169 HKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMqLVGQVPAALWDIfgedrfHWDATTIGISLAAFGILhSLAQA 248
Cdd:COG2807  196 PAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYA-VVAWLPPILRDA------GLSAATAGLLLSLFQLA-GIPGS 267

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 221360449 249 MITGPVAARLGERRALMLGMIADG-TGYILLAFATRGWMAFPIMV 292
Cdd:COG2807  268 LLVPLLADRLGDRRPLLLLLGLLGlAGLLGLLLAPGSLPWLWAVL 312

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

26-130

1.55e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.82 E-value: 1.55e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  26 TAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGIT-GATGAVAGAYI 104
Cdd:COG2814  242 ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALV 321

                         90       100
                 ....*....|....*....|....*.
gi 221360449 105 ADITDGDERARHFGFMSACFGFGMVA 130
Cdd:COG2814  322 AELAPPEARGRASGLYNSAFFLGGPL 347

PRK09874

multidrug efflux MFS transporter MdtG;

1-141

1.72e-06

multidrug efflux MFS transporter MdtG;

Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 48.76 E-value: 1.72e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   1 TLSASA*IMPVLPGLLRDLvhsnDVTAHY------GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIM 74
Cdd:PRK09874  26 TGAAFSLVMPFLPLYVEQL----GVTGHSalnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLM 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221360449  75 ATAPFLWVLYIRRIVAGITGATGAVAGAYIADITDGDERARHFGFMSAcfgfGMVAGPVLGGLMGGF 141
Cdd:PRK09874 102 GLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLST----GGVSGALLGPLAGGL 164

MFS_YxlH_like

cd17490

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...

9-138

3.47e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 47.99 E-value: 3.47e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   9 MPVLPGLLRDLVHSNDVTahyGILLALYALMQFACAPVLGALSDRFGRR-PVLLVSLAGAAVDYTIMATAPFLWVLYIRR 87
Cdd:cd17490   16 VPFLSPYAESLGASLSMI---GIILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIAR 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 221360449  88 IVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17490   93 FLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLI 143

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

11-138

3.76e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.57 E-value: 3.76e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  11 VLPGLLRDLVHSNDVTAhyGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPF-LWVLYIRRIV 89
Cdd:COG2223  227 WLPPYLVDQFGLSAATA--GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLL 304

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 221360449  90 AGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:COG2223  305 LGLaLGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354

2A0119

TIGR00898

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

44-101

4.20e-06

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 47.70 E-value: 4.20e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 221360449   44 APVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVAG 101
Cdd:TIGR00898 144 SFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQA 201

MFS_GLUT6_8_Class3_like

cd17358

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...

10-192

5.83e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 47.18 E-value: 5.83e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  10 PVLPGLLRDLVHSNDVT----AHYGILLALYALmqFACAPVlGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYI 85
Cdd:cd17358   23 PALPSLMSDNSLSLPLTvaqfSWFGSLLTLGAL--IGALLS-GKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  86 RRIVAGIT-GATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALnglnFLTGCFL 164
Cdd:cd17358  100 GRFLAGFGgGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRTLALIGAIPPVV----FLILLFF 175

                        170       180
                 ....*....|....*....|....*...
gi 221360449 165 LPESHKGERRPLRREALnpLASFRWARG 192
Cdd:cd17358  176 IPESPRWLAKKGREEEA--EKSLQFLRG 201

MFS_MFSD6

cd17335

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...

3-290

9.25e-06

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 46.42 E-value: 9.25e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   3 SASA*IMPVLPGLLRDLVHSNDVTahyGILLALYALMQFACAPVLGALSDRFG-RRPVLLVSLAGAAVDYTIMATAP--F 79
Cdd:cd17335   11 AALGSLLPFLSVYLKQLGLSPTQI---GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAqiF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  80 LWVLYIRRIVAGITGA----TGAVAGAYIADITDGDERARHFGfmSACFGFGMV-AGPVLGGLMGGFSPHAPFFAAAALN 154
Cdd:cd17335   88 WLLLLLVILGAFFSAPvvplVDSITLQYLGEERERYGKQRLWG--SIGFGIAALlVGILIDRSSTYKNYTIAFYVFAVLM 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 155 GLNFLTGCFLLPESHKGERRPLRREALNPLASFRWargmtvvAALMAVFFIMQLVGQVpaalwdIFGEDRFHWDAttIGI 234
Cdd:cd17335  166 LLALLLALKFPFRPKHPEPNENTGGLLALLRNPRV-------LAFLLVAFLMGFGHGL------IYSFLFWHLQD--LGG 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221360449 235 SLAAFGILHSLAQA------MITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPI 290
Cdd:cd17335  231 SKTLIGLLWTVGVVseipffFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPI 292

MFS_SLC18A3_VAChT

cd17383

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...

30-142

1.73e-05

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 45.77 E-value: 1.73e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  30 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVAG-AYIAD-I 107
Cdd:cd17383   33 GVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGlAMIADrF 112

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 221360449 108 TDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFS 142
Cdd:cd17383  113 TEEAERSKALGIALAFISFGCLVAPPFGGILYEFA 147

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

12-138

2.45e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.25 E-value: 2.45e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  12 LPGLLRDLVHSNDVTAhyGILLALYALMQFACAPVLGALSDRFGRR--PVLLVSLAGAAVDYTIMATAPFLWVLYIRRIV 89
Cdd:COG2271  203 LPTYLVEVRGLSLAQA--GLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFL 280

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 221360449  90 AGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:COG2271  281 AGFgLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

26-142

2.67e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.87 E-value: 2.67e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  26 TAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVAGA-YI 104
Cdd:cd17319   37 PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIkAL 116

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 221360449 105 ADITDGDERARHFGFMSACFGFG-MVAGPVLGGLMGGFS 142
Cdd:cd17319  117 AEWFPARERGRATGLFNSGAPLGaAIGPPLSGWLLLLFG 155

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

5-292

3.60e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 3.60e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   5 SA*IMPVLPGLLRDLVHSNdvtAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLY 84
Cdd:cd17478   12 QGFLPALLPLLIAKLGLSY---AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  85 IRRIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLmggFSPHAPFFAAAALNGLNFLTGCFL 164
Cdd:cd17478   89 LLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAA---LVALFGGLGLLILLIIPGLAVALL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 165 LPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFhWDATTIGISLAAFGILHS 244
Cdd:cd17478  166 LLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSLFLFAGA 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 221360449 245 LAQaMITGPVAARLGERRALMLGMIAdGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17478  245 IGT-LIGGPLSDRFGRRRVIIASLLL-AAPFLLLFLLTPGIWSYILLV 290

MFS_YcxA_like

cd17355

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...

24-138

4.02e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.57 E-value: 4.02e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  24 DVTAHYGILLALYALMQfacaPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI--TGATGAVAG 101
Cdd:cd17355   39 VISLAFTVGLLAFGLAQ----PFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGggAGTLAAVAF 114

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 221360449 102 AYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17355  115 ATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAAL 151

MFS_SLC22

cd17317

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...

34-135

4.29e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.49 E-value: 4.29e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  34 ALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGAT-GAVAGAYIADITDGDE 112
Cdd:cd17317   32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGiFTVGFVLGMEIVGPKY 111

                         90       100
                 ....*....|....*....|...
gi 221360449 113 RARHFGFMSACFGFGMVAGPVLG 135
Cdd:cd17317  112 RSFVGILFGLFWALGYMLLALLA 134

MFS_SLC18A1_2_VAT1_2

cd17384

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...

8-142

4.95e-05

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 44.10 E-value: 4.95e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   8 IMPVLPGLLRDLVHsndvtahYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRR 87
Cdd:cd17384   19 VVPIIPDYLNENVR-------VGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLAR 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 221360449  88 IVAGITGATGAVAG-AYIADI-TDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFS 142
Cdd:cd17384   92 ALQGVGSACSSVAGmGMLASLyPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFV 148

MFS_HMIT_like

cd17360

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...

11-115

5.11e-05

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 44.18 E-value: 5.11e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  11 VLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVA 90
Cdd:cd17360   19 ALLYIKDDLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLV 98

                         90       100
                 ....*....|....*....|....*.
gi 221360449  91 GI-TGATGAVAGAYIADITDGDERAR 115
Cdd:cd17360   99 GLgVGIASMTVPLYIAEAAPPRIRGR 124

Sugar_tr

pfam00083

Sugar (and other) transporter;

29-135

7.47e-05

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.80 E-value: 7.47e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   29 YGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPF---LWVLYIRRIVAGI-TGATGAVAGAYI 104
Cdd:pfam00083  48 SGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGkwsVYQLIVGRVLVGIgVGGASVLAPMYI 127

                          90       100       110
                  ....*....|....*....|....*....|.
gi 221360449  105 ADITDgderARHFGFMSACFGFGMVAGPVLG 135
Cdd:pfam00083 128 SEIAP----KKLRGALGSLYQLAITFGILLA 154

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

27-138

1.33e-04

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.97 E-value: 1.33e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  27 AHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMA---TAPFLWVLYIRRIVAGITGATGAVAGAY 103
Cdd:cd17316  213 ATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFyllSGSPTLLLLLLFILSFFVGGVWGALYAY 292

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 221360449 104 IADITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17316  293 LAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327

MFS_FucP_MFSD4_like

cd17333

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...

48-282

1.37e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.08 E-value: 1.37e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  48 GALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI-TGATGAVAGAYIADITDGDeRARHFGFMSACFGF 126
Cdd:cd17333   52 GFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLgAGILDTGANTFVGALFEES-SATRLNVLHGFFGL 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 127 GMVAGPVLGGLMG--GFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFF 204
Cdd:cd17333  131 GALIGPLIATSLLtsELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFL 210

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221360449 205 IMqlVGQVPAALWDI-FGEDRFHWDATTIGISLAAFGILhSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFAT 282
Cdd:cd17333  211 YV--GAETAFSSWVPsYLVEKKHVSDGLAGYLLSGFWVG-ITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAP 286

MFS_SLC18B1

cd17385

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...

31-138

1.96e-04

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 42.59 E-value: 1.96e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  31 ILLALYALMqfacAPVLGALSDRFGRRPVLLVS-LAGAAVDYTIMATAPF------LWVLYIRRIVAGItgatgAVAGAY 103
Cdd:cd17385  244 ILAGSYAIS----APLWGWLSDKKKIPKWLMVIgSIITGVGFLLLGPAPLlpikseLWMVIIGLVLLGL-----SLGAAL 314

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 221360449 104 IADITDGDERARHFGF-------------MSACFGFGMVAGPVLGGLM 138
Cdd:cd17385  315 VPTFPELLNCAREYGFpdnlstyglvsglFNAAFSLGAFIGPTLGGFL 362

emrD

PRK11652

multidrug transporter EmrD;

10-138

2.12e-04

multidrug transporter EmrD;

Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 42.20 E-value: 2.12e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  10 PVLPGLLRDL-VHSNDVTAHYGILLALYALMQFacapVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRI 88
Cdd:PRK11652  29 PAIADMARDLnVREGAVQAVMAAYLLTYGLSQL----FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 221360449  89 VAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:PRK11652 105 IQGLgTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLL 155

MFS_GLUT_like

cd17315

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...

48-169

2.28e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.18 E-value: 2.28e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  48 GALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGF 126
Cdd:cd17315   55 GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLgVGLASVLVPLYISEIAPAKIRGALGTLNQLMITF 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 221360449 127 GMVAGPVLGGLMG--GFSPHAPFFAAAALNGLNFLTGCFLLPESH 169
Cdd:cd17315  135 GILLAYLLGLALSlsPPGWWRLMFALAAVPALLQLLLMFFLPESR 179

PRK03893

putative sialic acid transporter; Provisional

46-129

2.39e-04

putative sialic acid transporter; Provisional

Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 42.38 E-value: 2.39e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  46 VLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGItgatgAVAGAYIADITDGDE------RARHFGF 119
Cdd:PRK03893  74 LLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGM-----GMAGEYGSSATYVIEswpkhlRNKASGF 148

                         90
                 ....*....|
gi 221360449 120 MSACFGFGMV 129
Cdd:PRK03893 149 LISGFSIGAV 158

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

4-141

2.63e-04

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 2.63e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   4 ASA*IMPVLPGLLRDLVHSNDvtAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVL 83
Cdd:cd06173  223 LGGALTVLLPLLAKEVLGGGA--AGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLL 300

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 221360449  84 YIRRIVAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGF 141
Cdd:cd06173  301 LAALFLLGLaGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA 359

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

44-138

3.11e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.80 E-value: 3.11e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  44 APVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI-TGATGAVAGAYIADITDGDERARHFGFMSA 122
Cdd:cd17365   51 ALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLgLGAAMPNAITLVSEYAPARRRSLAVTLMFC 130

                         90
                 ....*....|....*.
gi 221360449 123 CFGFGMVAGPVLGGLM 138
Cdd:cd17365  131 GYPLGAALGGFLAAAL 146

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

29-138

3.74e-04

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.44 E-value: 3.74e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  29 YGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGA-VAGAYIADI 107
Cdd:cd17329  238 LGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFpAVQTLVAAL 317

                         90       100       110
                 ....*....|....*....|....*....|.
gi 221360449 108 TDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17329  318 APPDKRGSYMGFYALAWGLGRAIGPLVGGLL 348

TRI12

pfam06609

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...

2-108

4.22e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.

Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 41.58 E-value: 4.22e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449    2 LSASA*impVLPGLLRDLVHSNDvtahYGILLALYALMQFACAPVLGALSDRFGRRPVLLVS----LAGAAVDYTIMATA 77
Cdd:pfam06609  60 LQASAS---ALPNILQDIGQSEN----QGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIAThiigLVGAIVGCTANKFN 132

                          90       100       110
                  ....*....|....*....|....*....|.
gi 221360449   78 PFLWVLYIRRIVAGITGATGAVAGAYIADIT 108
Cdd:pfam06609 133 TLLAAMTLLGVAAGPAGASPLFIGELMSNKT 163

MFS_3

pfam05977

Transmembrane secretion effector; This is a family of transport proteins. Members of this ...

37-292

6.02e-04

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.

Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 41.27 E-value: 6.02e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   37 ALMQFACAPVLGALSDRFGRRPVLLVS---LAGAAVDYTIMATAPFL--WVLYIRRIVAGITGATGAVA-GAYIADITDG 110
Cdd:pfam05977  55 TLPIFLLSIPAGALADNFDRRKIMLAGqllLALVSTLLTLLAGLGLLspWLLLGLTFLGGIGTALMDPAwQASVPELVPR 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  111 DERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLnFLTGCFLLPESHKGERRPLRREALNPL-ASFRW 189
Cdd:pfam05977 135 RDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNALSYF-AVIAALWRWKRAAPASPLPRERIFGAVrAGLRF 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  190 ARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGiLHSLAQAMITGPVAARLGERRALMLGMI 269
Cdd:pfam05977 214 TAMSRELRSVLVRAFAFGLSASAVWALLPLVARDLLDGDAIFYGILLGAVG-VGAILGALSLPRLRERLGSDRLVLLASV 292

                         250       260
                  ....*....|....*....|...
gi 221360449  270 ADGTGYILLAFATRGWMAFPIMV 292
Cdd:pfam05977 293 VTALVLLSLALAPNLWLAIPVLL 315

MFS_YcxA_like

cd17355

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...

4-138

7.00e-04

Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 7.00e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   4 ASA*IMPVLPGLLRDLVHSndvTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTI--MATAPFLW 81
Cdd:cd17355  225 AVVGLIVHLVPYLADRGIS---PAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALllLLPFPPLA 301

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 221360449  82 VLYIRRIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17355  302 LLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLL 358

MFS_OAT

cd17374

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...

44-137

8.19e-04

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 40.35 E-value: 8.19e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  44 APVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAV-AGAYIADITDGDERARHFGFMSA 122
Cdd:cd17374   52 ALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISInTLILGTEWTTPRHRALAITLTSC 131

                         90
                 ....*....|....*
gi 221360449 123 CFGFGMVagpVLGGL 137
Cdd:cd17374  132 FFSIGQM---LLAGL 143

BtlA

COG2270

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...

26-286

8.39e-04

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];

Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.52 E-value: 8.39e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  26 TAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIM--ATAPFLWVLYIRRIVAGITGATGAVA--G 101
Cdd:COG2270   51 TALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATAAlfFVAPGGLWLGLLLFVLANIGFEGSLVfyN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 102 AYIADITDGDERARHFGFMSAC----------FGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFL-LPESHK 170
Cdd:COG2270  131 AFLPDIATPEEIGRVSGLGWALgylggvllllINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLfLPERPR 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 171 GERRPLRREALNPL----ASFRWARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISL------AAFG 240
Cdd:COG2270  211 PGPAPPRGAVRAGFrelrRTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGllvqivAALG 290

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 221360449 241 ilhslaqAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWM 286
Cdd:COG2270  291 -------ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALA 329

BtlA

COG2270

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...

32-138

1.32e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];

Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.75 E-value: 1.32e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  32 LLALYALMQFACAP---VLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGIT-GATGAVAGAYIADI 107
Cdd:COG2270  276 LIVFGLLVQIVAALgalLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVmGGIQALSRSLLARL 355

                         90       100       110
                 ....*....|....*....|....*....|.
gi 221360449 108 TDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:COG2270  356 IPPGREAEFFGLYALSGKAASFLGPLLFGLV 386

MFS_ShiA_like

cd17369

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...

32-103

1.33e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.82 E-value: 1.33e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221360449  32 LLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVdytimATAPFLWVLYIRR----IVAGITGATGAVAGAY 103
Cdd:cd17369  269 AVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAAL-----FAFPFFWLLDTGStwliVLAAVVVLGVLHGMMY 339

MFS_SLC18B1

cd17385

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...

29-141

1.48e-03

Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 39.89 E-value: 1.48e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  29 YGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAV--------DYtIMATAPFLWVLYIRRIVAGITGATGAVA 100
Cdd:cd17385   36 IGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGctilfgflDR-VPDGTVFIALCFLVRIVEAVGFAAFITA 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 221360449 101 GAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGL---MGGF 141
Cdd:cd17385  115 SFAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFlyqAGGY 158

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

30-138

1.59e-03

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.47 E-value: 1.59e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  30 GILLALYALMQFACAPVLGALSDRFG-RRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVAGAYIADIT 108
Cdd:COG2807  253 GLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRA 332

                         90       100       110
                 ....*....|....*....|....*....|.
gi 221360449 109 -DGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:COG2807  333 rTPAEAAALSGMAQSVGYLLAALGPLLVGAL 363

MFS_3

pfam05977

Transmembrane secretion effector; This is a family of transport proteins. Members of this ...

2-91

1.70e-03

Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 39.73 E-value: 1.70e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449    2 LSASA*IMPVLPGLLRDLVHSNDVTahYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLW 81
Cdd:pfam05977 232 LSASA-VWALLPLVARDLLDGDAIF--YGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLW 308

                          90
                  ....*....|
gi 221360449   82 VLYIRRIVAG 91
Cdd:pfam05977 309 LAIPVLLLGG 318

MFS_YxlH_like

cd17490

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...

27-139

1.78e-03

Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 1.78e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  27 AHYGILLALYALMQFACAPVLGAL-SDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI-TGATGAVAGAYI 104
Cdd:cd17490  230 FQLGLLSIIYLLPNALASLLSGTLfYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFgTGILFPLLMSLS 309

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 221360449 105 ADITDGDERARHFGFMSACFGFGMVAGPVLGGLMG 139
Cdd:cd17490  310 IEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIIS 344

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

30-139

2.00e-03

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.09 E-value: 2.00e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  30 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI-TGATGAVAGAYIADIT 108
Cdd:cd17473  236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLV 315

                         90       100       110
                 ....*....|....*....|....*....|.
gi 221360449 109 DGDERARHFGFMSACFGFGMVAGPVLGGLMG 139
Cdd:cd17473  316 PPELRGRAMGIVTSAFFLGQFLSPLVLGPLV 346

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

30-138

2.42e-03

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.07 E-value: 2.42e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  30 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVAGAYIADITD 109
Cdd:cd17324  237 IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA 316

                         90       100
                 ....*....|....*....|....*....
gi 221360449 110 GDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd17324  317 PEARGLASSLYLAAYNLGGALGAALGGLV 345

MFS_SLC22A1_2_3

cd17379

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...

46-101

2.72e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 38.87 E-value: 2.72e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 221360449  46 VLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVAG 101
Cdd:cd17379   52 VIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTG 107

PRK11102

Bcr/CflA family multidrug efflux MFS transporter;

33-177

2.73e-03

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 38.74 E-value: 2.73e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  33 LALYALmQFACAPVL-GALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGAVA-GAYIADITDG 110
Cdd:PRK11102  32 LSAYIL-GFAIGQLFyGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVViNALMRDMFPK 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221360449 111 DERARHFGFMSACFGFGMVAGPVLGG-LMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERR-PLR 177
Cdd:PRK11102 111 EEFSRMMSFVTLVMTIAPLLAPIIGGwLLVWFSWHAIFWVLALAAILAAALVFFFIPETLPKERRqPFH 179

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

19-137

2.83e-03

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 2.83e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  19 LVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGATGA 98
Cdd:cd17478  222 LVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFP 301

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 221360449  99 VAGAYIADItdgdeRARHFGFMSA-----CFGFGMVAGPVLGGL 137
Cdd:cd17478  302 VTVVLAQEL-----LPGNVGLASGlmmglSFGLGGIGAPVLGAL 340

MFS_OFA_like

cd17353

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...

222-288

2.94e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 2.94e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221360449 222 EDRFHWDATTIGISLAAFGILHSLAqAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAF 288
Cdd:cd17353   30 SSALGWSLASVALAFTLTIVFLAIS-APFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLF 95

MFS_MFSD6

cd17335

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...

29-138

2.94e-03

Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 38.72 E-value: 2.94e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  29 YGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGIT-GATGAVAGAYIADI 107
Cdd:cd17335  235 IGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTfALVWAAAVSYASAA 314

                         90       100       110
                 ....*....|....*....|....*....|..
gi 221360449 108 TDGDERARHFGFMSA-CFGFGMVAGPVLGGLM 138
Cdd:cd17335  315 APPGLRATAQGLLQGlYFGLGGGLGSLIGGYL 346

PRK10489

enterobactin transporter EntS;

12-238

3.33e-03

enterobactin transporter EntS;

Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 38.81 E-value: 3.33e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  12 LPGLLRDLVHSndvTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMA-----TAPFLWVLYIR 86
Cdd:PRK10489  40 VPVQIQMMTGS---TLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLARGTCGLGFIGLAlnaflPEPSLLAIYLL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  87 RIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFG-FGMVAGPVLGGLM---GGFSPHAPFFAAAALNGLNFLTGC 162
Cdd:PRK10489 117 GLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVrLGSVISPALGGLLiaaGGVAWNYGLAAAGTFITLLPLLRL 196

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221360449 163 FLLPESHKGERRPLRREAlnplASFRWARGMTVVAALMAVFFIMQLVGQVpAALWDIFGEDRFHWDATTIGISLAA 238
Cdd:PRK10489 197 PALPPPPQPREHPLRSLL----AGFRFLLASPVVGGIALLGGLLTMASAV-RVLYPALADEVWQMGAAQIGLLYAA 267

MFS_HXT

cd17356

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...

26-168

3.54e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 38.39 E-value: 3.54e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  26 TAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATA-PFLWVLYIRRIVAGI-TGATGAVAGAY 103
Cdd:cd17356   44 SSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAiGKWYQLIVGRIIAGLgVGFASVLVPVY 123

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221360449 104 IADITDGDERarhfGFMSACFGFGMVAGPVLG-------GLMGGFSPHAPFFAAAALNGLNFLTGCFLLPES 168
Cdd:cd17356  124 QSEVAPKHIR----GTLVSLYQLAITIGILVAycinygtHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPES 191

MFS_OFA_like

cd17353

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...

33-292

3.84e-03

Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.36 E-value: 3.84e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  33 LALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYirrIVAGITGATGAvAGAYIADITDG-- 110
Cdd:cd17353   44 FTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLF---LGYGVLGGIGA-GIGYITPVSTAvk 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 111 ---DERARHFGFMSACFGFG-MVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLL----PESHKGERRPLRREALN 182
Cdd:cd17353  120 wfpDKRGLATGIVIAGFGLGsLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIrdppKGWVPPGVDPLANNAEN 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 183 PLASFRWARGMTVVA--ALMAVFFIMQLVGQVPAALWDIFGEDRFHWDATTIGISLAAFGILHSLAQAMItGPVAARLGE 260
Cdd:cd17353  200 SPRDYTPREMLRTPTfwLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFW-GWLSDKIGR 278

                        250       260       270
                 ....*....|....*....|....*....|..
gi 221360449 261 RRALMLGMIADGTGYILLAFATRGWMAFPIMV 292
Cdd:cd17353  279 KNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGV 310

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

1-138

5.19e-03

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.18 E-value: 5.19e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449   1 TLSASA*IMPVLPGLLRDLVHSNDVTAhyGILLALYALMQFACAPVLGALSDR-FGRRPVLLVSLAGAAVDYTIMATAPF 79
Cdd:cd06174  215 VNLAYYSFSTLLPLFLLDLGGLSVAVA--GLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPS 292

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  80 LWVLYIRRIVAGITGATG-AVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLM 138
Cdd:cd06174  293 LLLLLLLLLLLGFGLGGLlPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352

MFS_GLUT6_Class3

cd17434

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...

10-108

9.02e-03

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 37.50 E-value: 9.02e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  10 PVLPGLLRDLVHSNDVTAH----YGILLALYAlmqfaCAPVLGA--LSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVL 83
Cdd:cd17434   23 PVIPALEQGDDPRLHLNVHqiswFGSVFTLGA-----AAGGLSAmfLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWML 97

                         90       100
                 ....*....|....*....|....*.
gi 221360449  84 YIRRIVAGITGA-TGAVAGAYIADIT 108
Cdd:cd17434   98 LLGRFLTGFAGGiTAASIPVYVSEIS 123

MFS_XylE_like

cd17359

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...

48-168

9.32e-03

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 37.16 E-value: 9.32e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  48 GALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGI-TGATGAVAGAYIADITDGDERARHFGF------- 119
Cdd:cd17359   57 GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLaVGGASALVPMYIAEVAPAEIRGRLVSLnqlmivf 136

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 221360449 120 -MSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPES 168
Cdd:cd17359  137 gQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPES 186

MFS_SLC45_SUC

cd17313

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...

29-163

9.65e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 37.22 E-value: 9.65e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449  29 YGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYTIMATAPFLWVLYIRRIVAGITGAT-GAVAGAYIADI 107
Cdd:cd17313  283 GAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATiNINPYPLVSDY 362

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221360449 108 TdgDERARHFGFMSACFGF-----GMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCF 163
Cdd:cd17313  363 H--SESGRGQGTDTGLLNLaislaQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

185-288

9.79e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 37.16 E-value: 9.79e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221360449 185 ASFRWARGMTVVAALMAVFFIMQLVGQVPAALWDIFGEDrFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRAL 264
Cdd:COG2271    1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQAD-LGLSAAQLGLLASAFFLGYALGQ-IPAGLLADRFGRRRVL 78

                         90       100
                 ....*....|....*....|....
gi 221360449 265 MLGMIADGTGYILLAFATRGWMAF 288
Cdd:COG2271   79 AIGLLLWGLATLLFGFATSFWQLL 102

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01