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Conserved domains on  [gi|357427698|emb|CBS90643|]
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Cobalt transporter, subunit B (plasmid) [Azospirillum lipoferum 4B]

Protein Classification

CbtB domain-containing protein( domain architecture ID 10559970)

cobalt transporter subunit (CbtB) domain-containing protein may act as a cobalt transporter acting in concert with vitamin B12 biosynthesis systems

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CbtB pfam09489
Probable cobalt transporter subunit (CbtB); This entry represents a family of proteins which ...
 28-62 3.65e-11

Probable cobalt transporter subunit (CbtB); This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of a single transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localization with a protein (CbtA) predicted to have five additional transmembrane segments.


:

Pssm-ID: 430641  Cd Length: 50  Bit Score: 51.98  E-value: 3.65e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 357427698  28 ILLGSFLLYGVGFAQPQQIHDAAHDARHSFAFPCH 62
Cdd:pfam09489 16 LLLGLGLVFGVGFSQAPALHDAAHDTRHAAGFPCH 50
 
Name Accession Description Interval E-value
CbtB pfam09489
Probable cobalt transporter subunit (CbtB); This entry represents a family of proteins which ...
 28-62 3.65e-11

Probable cobalt transporter subunit (CbtB); This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of a single transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localization with a protein (CbtA) predicted to have five additional transmembrane segments.


Pssm-ID: 430641  Cd Length: 50  Bit Score: 51.98  E-value: 3.65e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 357427698  28 ILLGSFLLYGVGFAQPQQIHDAAHDARHSFAFPCH 62
Cdd:pfam09489 16 LLLGLGLVFGVGFSQAPALHDAAHDTRHAAGFPCH 50
CbtB TIGR02459
cobalt transporter subunit CbtB (proposed); This model represents a family of proteins which ...
 1-62 3.90e-09

cobalt transporter subunit CbtB (proposed); This model represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of a single trans-membrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localization with a protein (CbtA) predicted to have five additional trans-membrane segments.


Pssm-ID: 131512  Cd Length: 60  Bit Score: 47.13  E-value: 3.90e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 357427698   1 MTTRSIHTAAGSATRSAAQTAVAAFaaILLGSFLLYGVGFAQPQQIHDAAHDARHSFAFPCH 62
Cdd:TIGR02459  1 MSTNSLTSSAASSVSAARLAAALVA--ALLGLFLVYFVGFSHIDAVHNAAHDTRHSAAFPCH 60
 
Name Accession Description Interval E-value
CbtB pfam09489
Probable cobalt transporter subunit (CbtB); This entry represents a family of proteins which ...
 28-62 3.65e-11

Probable cobalt transporter subunit (CbtB); This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of a single transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localization with a protein (CbtA) predicted to have five additional transmembrane segments.


Pssm-ID: 430641  Cd Length: 50  Bit Score: 51.98  E-value: 3.65e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 357427698  28 ILLGSFLLYGVGFAQPQQIHDAAHDARHSFAFPCH 62
Cdd:pfam09489 16 LLLGLGLVFGVGFSQAPALHDAAHDTRHAAGFPCH 50
CbtB TIGR02459
cobalt transporter subunit CbtB (proposed); This model represents a family of proteins which ...
 1-62 3.90e-09

cobalt transporter subunit CbtB (proposed); This model represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of a single trans-membrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localization with a protein (CbtA) predicted to have five additional trans-membrane segments.


Pssm-ID: 131512  Cd Length: 60  Bit Score: 47.13  E-value: 3.90e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 357427698   1 MTTRSIHTAAGSATRSAAQTAVAAFaaILLGSFLLYGVGFAQPQQIHDAAHDARHSFAFPCH 62
Cdd:TIGR02459  1 MSTNSLTSSAASSVSAARLAAALVA--ALLGLFLVYFVGFSHIDAVHNAAHDTRHSAAFPCH 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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