NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|313742146|emb|CBY65610|]
View 

unnamed protein product [Homo sapiens]

Protein Classification

eukaryotic translation initiation factor 4E( domain architecture ID 10483299)

eukaryotic translation initiation factor 4E (EIF4E) recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of secondary structures of mRNAs

CATH:  3.30.760.10
PubMed:  30636602|31074051
SCOP:  4001578

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
IF4E pfam01652
Eukaryotic initiation factor 4E;
38-197 1.80e-88

Eukaryotic initiation factor 4E;


:

Pssm-ID: 460281  Cd Length: 158  Bit Score: 257.45  E-value: 1.80e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146   38 PLQNRWALWF-FKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLIT 116
Cdd:pfam01652   1 PLQNTWTLWYdTKPDKSKSYEDNLKKIGTFDTVEDFWSLYNHIKPPSELPPGSDYHLFKEGIKPMWEDPANKNGGKWIIR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146  117 LNKQQRrsdLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIG 196
Cdd:pfam01652  81 LKKKGL---LDRLWEDLLLALIGEQFDEDSDEICGAVVSVRKKEDKISIWTRDASDEEAVLKIGKKLKEVLGLPPNTKIE 157

                  .
gi 313742146  197 Y 197
Cdd:pfam01652 158 Y 158
 
Name Accession Description Interval E-value
IF4E pfam01652
Eukaryotic initiation factor 4E;
38-197 1.80e-88

Eukaryotic initiation factor 4E;


Pssm-ID: 460281  Cd Length: 158  Bit Score: 257.45  E-value: 1.80e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146   38 PLQNRWALWF-FKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLIT 116
Cdd:pfam01652   1 PLQNTWTLWYdTKPDKSKSYEDNLKKIGTFDTVEDFWSLYNHIKPPSELPPGSDYHLFKEGIKPMWEDPANKNGGKWIIR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146  117 LNKQQRrsdLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIG 196
Cdd:pfam01652  81 LKKKGL---LDRLWEDLLLALIGEQFDEDSDEICGAVVSVRKKEDKISIWTRDASDEEAVLKIGKKLKEVLGLPPNTKIE 157

                  .
gi 313742146  197 Y 197
Cdd:pfam01652 158 Y 158
CDC33 COG5053
Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];
36-214 1.92e-47

Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227386  Cd Length: 217  Bit Score: 155.44  E-value: 1.92e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146  36 KHPLQNRWALWFFKN--DKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRW 113
Cdd:COG5053   36 KHPLAFHWTLWFLKPpeDGLESWSDLLKSIITFETVEEFWYILHNISDASRLPRKSDYNVFREGIRPEWEDEANMNGGKW 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146 114 lITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKI 193
Cdd:COG5053  116 -SFQLKGKGCDRLDELWLRTLLAAIGETLDPTGSEIGGVVGNMRKGFYKLAIWTRNCNNKDVLGAIGNEFKQVLELSDVE 194
                        170       180
                 ....*....|....*....|.
gi 313742146 194 VIGYQSHadTATKSGSTTKNR 214
Cdd:COG5053  195 TLEYKAH--ESSKLGSYHAKT 213
PTZ00040 PTZ00040
translation initiation factor E4; Provisional
38-179 6.05e-16

translation initiation factor E4; Provisional


Pssm-ID: 240238  Cd Length: 233  Bit Score: 73.69  E-value: 6.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146  38 PLQNRWALW----FFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYS---------------LFKDGI 98
Cdd:PTZ00040  39 PLSYKWVIWeqvvKETIRKSNDYKDYTKPLASFDSVQKFWQLWFNIPQPSELLTGKRMIressdgsehvvdavmIFKDGI 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146  99 EPMWEDEKNKRGGRWLITLN-KQQRRSDLDRFWLETLLCLIGESFDDYS--------DDVCGAVVNVRakgdkIAIWTTE 169
Cdd:PTZ00040 119 QPMWEDPMNATGGHFEYRFWpTDVSPGQIDEYWNNLVLALIGSSLEHSSlingirlvDKLSGRFGVIR-----IEIWFTN 193
                        170
                 ....*....|
gi 313742146 170 CENREAVTHI 179
Cdd:PTZ00040 194 LGDQSDRNQL 203
 
Name Accession Description Interval E-value
IF4E pfam01652
Eukaryotic initiation factor 4E;
38-197 1.80e-88

Eukaryotic initiation factor 4E;


Pssm-ID: 460281  Cd Length: 158  Bit Score: 257.45  E-value: 1.80e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146   38 PLQNRWALWF-FKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLIT 116
Cdd:pfam01652   1 PLQNTWTLWYdTKPDKSKSYEDNLKKIGTFDTVEDFWSLYNHIKPPSELPPGSDYHLFKEGIKPMWEDPANKNGGKWIIR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146  117 LNKQQRrsdLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIG 196
Cdd:pfam01652  81 LKKKGL---LDRLWEDLLLALIGEQFDEDSDEICGAVVSVRKKEDKISIWTRDASDEEAVLKIGKKLKEVLGLPPNTKIE 157

                  .
gi 313742146  197 Y 197
Cdd:pfam01652 158 Y 158
CDC33 COG5053
Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];
36-214 1.92e-47

Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227386  Cd Length: 217  Bit Score: 155.44  E-value: 1.92e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146  36 KHPLQNRWALWFFKN--DKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRW 113
Cdd:COG5053   36 KHPLAFHWTLWFLKPpeDGLESWSDLLKSIITFETVEEFWYILHNISDASRLPRKSDYNVFREGIRPEWEDEANMNGGKW 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146 114 lITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKI 193
Cdd:COG5053  116 -SFQLKGKGCDRLDELWLRTLLAAIGETLDPTGSEIGGVVGNMRKGFYKLAIWTRNCNNKDVLGAIGNEFKQVLELSDVE 194
                        170       180
                 ....*....|....*....|.
gi 313742146 194 VIGYQSHadTATKSGSTTKNR 214
Cdd:COG5053  195 TLEYKAH--ESSKLGSYHAKT 213
PTZ00040 PTZ00040
translation initiation factor E4; Provisional
38-179 6.05e-16

translation initiation factor E4; Provisional


Pssm-ID: 240238  Cd Length: 233  Bit Score: 73.69  E-value: 6.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146  38 PLQNRWALW----FFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYS---------------LFKDGI 98
Cdd:PTZ00040  39 PLSYKWVIWeqvvKETIRKSNDYKDYTKPLASFDSVQKFWQLWFNIPQPSELLTGKRMIressdgsehvvdavmIFKDGI 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313742146  99 EPMWEDEKNKRGGRWLITLN-KQQRRSDLDRFWLETLLCLIGESFDDYS--------DDVCGAVVNVRakgdkIAIWTTE 169
Cdd:PTZ00040 119 QPMWEDPMNATGGHFEYRFWpTDVSPGQIDEYWNNLVLALIGSSLEHSSlingirlvDKLSGRFGVIR-----IEIWFTN 193
                        170
                 ....*....|
gi 313742146 170 CENREAVTHI 179
Cdd:PTZ00040 194 LGDQSDRNQL 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure