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Conserved domains on  [gi|803432598|emb|CCW43579|]
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gp120, partial [HIV-1 M:CRF15_H_ARN_pl_H9]

Protein Classification

envelope glycoprotein 120( domain architecture ID 2)

envelope glycoprotein 120 (GP120) plays a key role during the first step of viral infection

Gene Ontology:  GO:0019062
PubMed:  27384653|25163695

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GP120 super family cl02884
Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss: ...
1-297 1.79e-120

Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.


The actual alignment was detected with superfamily member pfam00516:

Pssm-ID: 278917  Cd Length: 525  Bit Score: 355.24  E-value: 1.79e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598    1 PQEIDLGNVTENFNMWKNNMVEQMHEDIISLWDESLKPCVKLTPLCVTLNCS----HQITTHNITNNVTDMR-------- 68
Cdd:pfam00516  48 PQEIILVNVTEAFDAWKNDMTEQAHEDIIHLFDQSIKPCVKLTPLCVALKCSdlkgDTNTPNPRTSSSTTSRpnssaari 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598   69 ------------------EGMKNCSFNMTTELRDKSKNVYSLFYRLDIVPIDGnnNNNNSEYRLINCNVSTIKQACPKVT 130
Cdd:pfam00516 128 imekgncienntcaglgyEEIKNCEFNIKTGIEGDKKKEYADFWKLDDIPCDN--DTAGTCYKLRHCNTSIIKEACDKHS 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598  131 FDPIPIHYCAPAGYAILKCKDKNFNGTGP-CKNVSTVQCTHGIKPVVSTQLLLNGSLAEEEVVI----RSENITNNAKTI 205
Cdd:pfam00516 206 FDAIPFHYCAPAGFAILKCNDKNFNGFEPkCTKVSAAQCTHGIEPQTSTQFGFNGSLAEEETVIywhgRSVNFTDNAKTI 285
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598  206 IVQFDEP--VQITCTRPNNNTRQGVHI--GPGQVFYATGEVIG-DVRQAHCDVSATDWDKALQKVATKLGKHF------- 273
Cdd:pfam00516 286 IVQLNKYynLEINCKRPGNKTRKPIRImrGPGRAFVFHGKIGNmRPRQAHCNFGRAKWNEALKEIAQKLREHPrykgfgd 365
                         330       340
                  ....*....|....*....|....*
gi 803432598  274 NKTIIFTE-SSGGDLEITTHSFNCG 297
Cdd:pfam00516 366 NGKIIFTKpGAGGDPEIAFHSFNCG 390
 
Name Accession Description Interval E-value
GP120 pfam00516
Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss: ...
1-297 1.79e-120

Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.


Pssm-ID: 278917  Cd Length: 525  Bit Score: 355.24  E-value: 1.79e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598    1 PQEIDLGNVTENFNMWKNNMVEQMHEDIISLWDESLKPCVKLTPLCVTLNCS----HQITTHNITNNVTDMR-------- 68
Cdd:pfam00516  48 PQEIILVNVTEAFDAWKNDMTEQAHEDIIHLFDQSIKPCVKLTPLCVALKCSdlkgDTNTPNPRTSSSTTSRpnssaari 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598   69 ------------------EGMKNCSFNMTTELRDKSKNVYSLFYRLDIVPIDGnnNNNNSEYRLINCNVSTIKQACPKVT 130
Cdd:pfam00516 128 imekgncienntcaglgyEEIKNCEFNIKTGIEGDKKKEYADFWKLDDIPCDN--DTAGTCYKLRHCNTSIIKEACDKHS 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598  131 FDPIPIHYCAPAGYAILKCKDKNFNGTGP-CKNVSTVQCTHGIKPVVSTQLLLNGSLAEEEVVI----RSENITNNAKTI 205
Cdd:pfam00516 206 FDAIPFHYCAPAGFAILKCNDKNFNGFEPkCTKVSAAQCTHGIEPQTSTQFGFNGSLAEEETVIywhgRSVNFTDNAKTI 285
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598  206 IVQFDEP--VQITCTRPNNNTRQGVHI--GPGQVFYATGEVIG-DVRQAHCDVSATDWDKALQKVATKLGKHF------- 273
Cdd:pfam00516 286 IVQLNKYynLEINCKRPGNKTRKPIRImrGPGRAFVFHGKIGNmRPRQAHCNFGRAKWNEALKEIAQKLREHPrykgfgd 365
                         330       340
                  ....*....|....*....|....*
gi 803432598  274 NKTIIFTE-SSGGDLEITTHSFNCG 297
Cdd:pfam00516 366 NGKIIFTKpGAGGDPEIAFHSFNCG 390
 
Name Accession Description Interval E-value
GP120 pfam00516
Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss: ...
1-297 1.79e-120

Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.


Pssm-ID: 278917  Cd Length: 525  Bit Score: 355.24  E-value: 1.79e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598    1 PQEIDLGNVTENFNMWKNNMVEQMHEDIISLWDESLKPCVKLTPLCVTLNCS----HQITTHNITNNVTDMR-------- 68
Cdd:pfam00516  48 PQEIILVNVTEAFDAWKNDMTEQAHEDIIHLFDQSIKPCVKLTPLCVALKCSdlkgDTNTPNPRTSSSTTSRpnssaari 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598   69 ------------------EGMKNCSFNMTTELRDKSKNVYSLFYRLDIVPIDGnnNNNNSEYRLINCNVSTIKQACPKVT 130
Cdd:pfam00516 128 imekgncienntcaglgyEEIKNCEFNIKTGIEGDKKKEYADFWKLDDIPCDN--DTAGTCYKLRHCNTSIIKEACDKHS 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598  131 FDPIPIHYCAPAGYAILKCKDKNFNGTGP-CKNVSTVQCTHGIKPVVSTQLLLNGSLAEEEVVI----RSENITNNAKTI 205
Cdd:pfam00516 206 FDAIPFHYCAPAGFAILKCNDKNFNGFEPkCTKVSAAQCTHGIEPQTSTQFGFNGSLAEEETVIywhgRSVNFTDNAKTI 285
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803432598  206 IVQFDEP--VQITCTRPNNNTRQGVHI--GPGQVFYATGEVIG-DVRQAHCDVSATDWDKALQKVATKLGKHF------- 273
Cdd:pfam00516 286 IVQLNKYynLEINCKRPGNKTRKPIRImrGPGRAFVFHGKIGNmRPRQAHCNFGRAKWNEALKEIAQKLREHPrykgfgd 365
                         330       340
                  ....*....|....*....|....*
gi 803432598  274 NKTIIFTE-SSGGDLEITTHSFNCG 297
Cdd:pfam00516 366 NGKIIFTKpGAGGDPEIAFHSFNCG 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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