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Conserved domains on  [gi|524088742|emb|CCY67708|]
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putative uncharacterized protein [Clostridium sp. CAG:678]

Protein Classification

suppressor of fused domain protein( domain architecture ID 10523843)

suppressor of fused (Sufu) domain protein similar to Bacillus subtilis antitoxin YqcF, a component of a type II toxin-antitoxin (TA) system that neutralizes the RNase activity of cognate toxin YqcG

Gene Ontology:  GO:0005737
PubMed:  20836087

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SUFU pfam05076
Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila ...
 34-185 1.40e-24

Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.


:

Pssm-ID: 461543  Cd Length: 171  Bit Score: 94.30  E-value: 1.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524088742   34 IDLMICENCPDEGITSYGTIGLFNCNIGL---TYEEKPLCMELLAACASSIEDFANIVTTTAFEIM---------DGKSV 101
Cdd:pfam05076   5 LDILSIPDTPEPGHWHYVTLGLSDLPMDEpedLEEDSGPRAELTFRLPKDEESLADEPPTWPLNLLqnlarypfkEGTWL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524088742  102 YPGYIFD--DVVSMYIgNSDMEHILLTYPFlWGDVHNSV--FDDITVAYLMAVPISDKEKEYCLKNGLDAL-ESVFEEKQ 176
Cdd:pfam05076  85 GPGHTIPngGPIPLAE-NTDLTGLLLVEPL-DDEELGALetPGGKKVNFLQLVPITEEELEYALEKGADALlELLLEEGP 162


                  ....*....
gi 524088742  177 IDIFDIFRP 185
Cdd:pfam05076 163 IDITDLNRK 171
 
Name Accession Description Interval E-value
SUFU pfam05076
Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila ...
 34-185 1.40e-24

Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.


Pssm-ID: 461543  Cd Length: 171  Bit Score: 94.30  E-value: 1.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524088742   34 IDLMICENCPDEGITSYGTIGLFNCNIGL---TYEEKPLCMELLAACASSIEDFANIVTTTAFEIM---------DGKSV 101
Cdd:pfam05076   5 LDILSIPDTPEPGHWHYVTLGLSDLPMDEpedLEEDSGPRAELTFRLPKDEESLADEPPTWPLNLLqnlarypfkEGTWL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524088742  102 YPGYIFD--DVVSMYIgNSDMEHILLTYPFlWGDVHNSV--FDDITVAYLMAVPISDKEKEYCLKNGLDAL-ESVFEEKQ 176
Cdd:pfam05076  85 GPGHTIPngGPIPLAE-NTDLTGLLLVEPL-DDEELGALetPGGKKVNFLQLVPITEEELEYALEKGADALlELLLEEGP 162


                  ....*....
gi 524088742  177 IDIFDIFRP 185
Cdd:pfam05076 163 IDITDLNRK 171
 
Name Accession Description Interval E-value
SUFU pfam05076
Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila ...
 34-185 1.40e-24

Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.


Pssm-ID: 461543  Cd Length: 171  Bit Score: 94.30  E-value: 1.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524088742   34 IDLMICENCPDEGITSYGTIGLFNCNIGL---TYEEKPLCMELLAACASSIEDFANIVTTTAFEIM---------DGKSV 101
Cdd:pfam05076   5 LDILSIPDTPEPGHWHYVTLGLSDLPMDEpedLEEDSGPRAELTFRLPKDEESLADEPPTWPLNLLqnlarypfkEGTWL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524088742  102 YPGYIFD--DVVSMYIgNSDMEHILLTYPFlWGDVHNSV--FDDITVAYLMAVPISDKEKEYCLKNGLDAL-ESVFEEKQ 176
Cdd:pfam05076  85 GPGHTIPngGPIPLAE-NTDLTGLLLVEPL-DDEELGALetPGGKKVNFLQLVPITEEELEYALEKGADALlELLLEEGP 162


                  ....*....
gi 524088742  177 IDIFDIFRP 185
Cdd:pfam05076 163 IDITDLNRK 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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