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Conserved domains on  [gi|674574518|emb|CDS41447|]
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protein groucho 2 [Echinococcus multilocularis]

Protein Classification

TLE_N and WD40 domain-containing protein( domain architecture ID 13692432)

TLE_N and WD40 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 15-138 9.89e-66

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


:

Pssm-ID: 461094  Cd Length: 117  Bit Score: 216.14  E-value: 9.89e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518   15 IKFSVPDACDRIKDELSYLQQQCHTLKVECERLTQEKTELHRIYMVYYELAYGLNVEIHKqvnvffhrslQTEISKRLGA 94
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK----------QTEIAKRLNA 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 674574518   95 IIAQVLPYLPQEHQAQVAAAVERAKQVTLPELNNLISQHQLLFA 138
Cdd:pfam03920  71 ICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQA 114
WD40 COG2319
WD40 repeat [General function prediction only];
694-988 1.80e-29

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.94  E-value: 1.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 694 HGEVVCAVMINSSTRHIYTGGK-GTVKLWDLAaataegaptvSKSPLATmdcLQG-GNYIRSIKMGQEGNLLVVGGEASV 771
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA----------TGKLLRT---LTGhSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 772 VSIWDMggLTPRPKGEIDIGVQACYAVAVSNDSKLCYFCQSDGVISVWDLHNQSQIRRLQGHGDGASCVDLSATCAQLWT 851
Cdd:COG2319  186 VRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 852 GGLDKTVRNWDIREmHRQIAQFN-FNSQIFSLAKSPTEEWVAAGMESDEIELF--APGRMdRYRLRMHESCVLSLKFAHS 928
Cdd:COG2319  264 GSADGTVRLWDLAT-GELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWdlATGKL-LRTLTGHTGAVRSVAFSPD 341

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 674574518 929 GAWFASTGKDSWLNAWRPPWGANLFRVKE-SLSVLSCDISADDRHLVTGSGDRRASIYEIN 988
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
PPE super family cl35037
PPE-repeat protein [Function unknown];
81-286 2.20e-03

PPE-repeat protein [Function unknown];


The actual alignment was detected with superfamily member COG5651:

Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 41.42  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  81 HRSLQTEISKRLGAIIAQVLPYLPQEHQAQVAAAVERAKQVTLPELNNlisqhQLLFAGANPIGGQLAAAFPPPGIPGLP 160
Cdd:COG5651  180 LLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPG-----NTGFAGTGAAAGAAAAAAAAAAAAGAG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 161 QPPSSTVNGAGTLSSSPAGGVNSLSGTLLSLPGAPPNPFAPPITSASGPNVSTTTPNAGAFLGAPTSTSPGFPNSNLAQS 240
Cdd:COG5651  255 ASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAGAALGAGAAA 334

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 674574518 241 QSAMAAAMAAMAAGLQTNSAAAFGFPNSQTPNSSPAGLAANSLLPN 286
Cdd:COG5651  335 AAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASG 380
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 152-440 3.74e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  152 PPPGIPGLPQPPSsTVNGAGTLSSSPAGGVNSLSGTLLSLPGAPPNPFAPPITSASGpnvSTTTPNAGAflGAPTSTSPG 231
Cdd:PHA03247 2712 PHALVSATPLPPG-PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP---APAPPAAPA--AGPPRRLTR 2785

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  232 FPNSNLAQSQSAMAAAMAAMAAglqtnSAAAFGFPNSQTPNSSPAGLAANsllPNMMSPTAlsalmgdksmdekqraaaa 311
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADP-----PAAVLAPAAALPPAASPAGPLPP---PTSAQPTA------------------- 2838

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  312 AVAAAMTAAVAQQQCGGLTGVDPTAMMATianmSQSAPGTGFDLSHtacaaaaAAAAAAGVLPPPPPAPAPPQPPSGLPS 391
Cdd:PHA03247 2839 PPPPPGPPPPSLPLGGSVAPGGDVRRRPP----SRSPAAKPAAPAR-------PPVRRLARPAVSRSTESFALPPDQPER 2907

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 674574518  392 APAPLPEVPPTAAAVPPIPPLPSSAEPPRLHSPQALGASSPTQPARASS 440
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 15-138 9.89e-66

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 216.14  E-value: 9.89e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518   15 IKFSVPDACDRIKDELSYLQQQCHTLKVECERLTQEKTELHRIYMVYYELAYGLNVEIHKqvnvffhrslQTEISKRLGA 94
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK----------QTEIAKRLNA 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 674574518   95 IIAQVLPYLPQEHQAQVAAAVERAKQVTLPELNNLISQHQLLFA 138
Cdd:pfam03920  71 ICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQA 114
WD40 COG2319
WD40 repeat [General function prediction only];
694-988 1.80e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.94  E-value: 1.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 694 HGEVVCAVMINSSTRHIYTGGK-GTVKLWDLAaataegaptvSKSPLATmdcLQG-GNYIRSIKMGQEGNLLVVGGEASV 771
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA----------TGKLLRT---LTGhSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 772 VSIWDMggLTPRPKGEIDIGVQACYAVAVSNDSKLCYFCQSDGVISVWDLHNQSQIRRLQGHGDGASCVDLSATCAQLWT 851
Cdd:COG2319  186 VRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 852 GGLDKTVRNWDIREmHRQIAQFN-FNSQIFSLAKSPTEEWVAAGMESDEIELF--APGRMdRYRLRMHESCVLSLKFAHS 928
Cdd:COG2319  264 GSADGTVRLWDLAT-GELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWdlATGKL-LRTLTGHTGAVRSVAFSPD 341

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 674574518 929 GAWFASTGKDSWLNAWRPPWGANLFRVKE-SLSVLSCDISADDRHLVTGSGDRRASIYEIN 988
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 689-986 3.14e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.51  E-value: 3.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 689 IQTIE-HGEVVCAVMINSSTRHIYTGGK-GTVKLWDLAAATAEGAPTVSKSPLATMDCLQGGNYirsikmgqegnlLVVG 766
Cdd:cd00200    2 RRTLKgHTGGVTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY------------LASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 767 GEASVVSIWDMGglTPRPKGEIdIGV-QACYAVAVSNDSKLCYFCQSDGVISVWDLHNQSQIRRLQGHGDGASCVDLSAT 845
Cdd:cd00200   70 SSDKTIRLWDLE--TGECVRTL-TGHtSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 846 CAQLWTGGLDKTVRNWDIREMHRqIAQFN-FNSQIFSLAKSPTEEWVAAGMESDEIELFAPgRMDR--YRLRMHESCVLS 922
Cdd:cd00200  147 GTFVASSSQDGTIKLWDLRTGKC-VATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKclGTLRGHENGVNS 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 674574518 923 LKFAHSGAWFASTGKDSWLNAWRppwgANLFRVKESL-----SVLSCDISADDRHLVTGSGDRRASIYE 986
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLsghtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 823-862 3.89e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.89e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 674574518   823 NQSQIRRLQGHGDGASCVDLSATCAQLWTGGLDKTVRNWD 862
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
825-862 1.00e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 674574518  825 SQIRRLQGHGDGASCVDLSATCAQLWTGGLDKTVRNWD 862
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PPE COG5651
PPE-repeat protein [Function unknown];
81-286 2.20e-03

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 41.42  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  81 HRSLQTEISKRLGAIIAQVLPYLPQEHQAQVAAAVERAKQVTLPELNNlisqhQLLFAGANPIGGQLAAAFPPPGIPGLP 160
Cdd:COG5651  180 LLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPG-----NTGFAGTGAAAGAAAAAAAAAAAAGAG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 161 QPPSSTVNGAGTLSSSPAGGVNSLSGTLLSLPGAPPNPFAPPITSASGPNVSTTTPNAGAFLGAPTSTSPGFPNSNLAQS 240
Cdd:COG5651  255 ASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAGAALGAGAAA 334

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 674574518 241 QSAMAAAMAAMAAGLQTNSAAAFGFPNSQTPNSSPAGLAANSLLPN 286
Cdd:COG5651  335 AAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASG 380
PHA03247 PHA03247
large tegument protein UL36; Provisional
 152-440 3.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  152 PPPGIPGLPQPPSsTVNGAGTLSSSPAGGVNSLSGTLLSLPGAPPNPFAPPITSASGpnvSTTTPNAGAflGAPTSTSPG 231
Cdd:PHA03247 2712 PHALVSATPLPPG-PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP---APAPPAAPA--AGPPRRLTR 2785

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  232 FPNSNLAQSQSAMAAAMAAMAAglqtnSAAAFGFPNSQTPNSSPAGLAANsllPNMMSPTAlsalmgdksmdekqraaaa 311
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADP-----PAAVLAPAAALPPAASPAGPLPP---PTSAQPTA------------------- 2838

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  312 AVAAAMTAAVAQQQCGGLTGVDPTAMMATianmSQSAPGTGFDLSHtacaaaaAAAAAAGVLPPPPPAPAPPQPPSGLPS 391
Cdd:PHA03247 2839 PPPPPGPPPPSLPLGGSVAPGGDVRRRPP----SRSPAAKPAAPAR-------PPVRRLARPAVSRSTESFALPPDQPER 2907

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 674574518  392 APAPLPEVPPTAAAVPPIPPLPSSAEPPRLHSPQALGASSPTQPARASS 440
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 15-138 9.89e-66

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 216.14  E-value: 9.89e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518   15 IKFSVPDACDRIKDELSYLQQQCHTLKVECERLTQEKTELHRIYMVYYELAYGLNVEIHKqvnvffhrslQTEISKRLGA 94
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK----------QTEIAKRLNA 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 674574518   95 IIAQVLPYLPQEHQAQVAAAVERAKQVTLPELNNLISQHQLLFA 138
Cdd:pfam03920  71 ICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQA 114
WD40 COG2319
WD40 repeat [General function prediction only];
694-988 1.80e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.94  E-value: 1.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 694 HGEVVCAVMINSSTRHIYTGGK-GTVKLWDLAaataegaptvSKSPLATmdcLQG-GNYIRSIKMGQEGNLLVVGGEASV 771
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA----------TGKLLRT---LTGhSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 772 VSIWDMggLTPRPKGEIDIGVQACYAVAVSNDSKLCYFCQSDGVISVWDLHNQSQIRRLQGHGDGASCVDLSATCAQLWT 851
Cdd:COG2319  186 VRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 852 GGLDKTVRNWDIREmHRQIAQFN-FNSQIFSLAKSPTEEWVAAGMESDEIELF--APGRMdRYRLRMHESCVLSLKFAHS 928
Cdd:COG2319  264 GSADGTVRLWDLAT-GELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWdlATGKL-LRTLTGHTGAVRSVAFSPD 341

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 674574518 929 GAWFASTGKDSWLNAWRPPWGANLFRVKE-SLSVLSCDISADDRHLVTGSGDRRASIYEIN 988
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 689-986 3.14e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.51  E-value: 3.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 689 IQTIE-HGEVVCAVMINSSTRHIYTGGK-GTVKLWDLAAATAEGAPTVSKSPLATMDCLQGGNYirsikmgqegnlLVVG 766
Cdd:cd00200    2 RRTLKgHTGGVTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY------------LASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 767 GEASVVSIWDMGglTPRPKGEIdIGV-QACYAVAVSNDSKLCYFCQSDGVISVWDLHNQSQIRRLQGHGDGASCVDLSAT 845
Cdd:cd00200   70 SSDKTIRLWDLE--TGECVRTL-TGHtSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 846 CAQLWTGGLDKTVRNWDIREMHRqIAQFN-FNSQIFSLAKSPTEEWVAAGMESDEIELFAPgRMDR--YRLRMHESCVLS 922
Cdd:cd00200  147 GTFVASSSQDGTIKLWDLRTGKC-VATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKclGTLRGHENGVNS 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 674574518 923 LKFAHSGAWFASTGKDSWLNAWRppwgANLFRVKESL-----SVLSCDISADDRHLVTGSGDRRASIYE 986
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLsghtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
690-988 1.96e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 1.96e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 690 QTIEHGEVVCAVMINSSTRHIYTGGKGTVKLWDLAAATAEGAPTVSKSPlatmdclqggnyIRSIKMGQEGNLLVVGGEA 769
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA------------VLSVAFSPDGRLLASASAD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 770 SVVSIWDMggLTPRPKGEIDIGVQACYAVAVSNDSKLCYFCQSDGVISVWDLHNQSQIRRLQGHGDGASCVDLSATCAQL 849
Cdd:COG2319  100 GTVRLWDL--ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 850 WTGGLDKTVRNWDIREmHRQIAQFN-FNSQIFSLAKSPTEEWVAAGMESDEIELF-APGRMDRYRLRMHESCVLSLKFAH 927
Cdd:COG2319  178 ASGSDDGTVRLWDLAT-GKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWdLATGKLLRTLTGHSGSVRSVAFSP 256

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 674574518 928 SGAWFASTGKDSWLNAWRPPWGANLFRVKESLS-VLSCDISADDRHLVTGSGDRRASIYEIN 988
Cdd:COG2319  257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 795-988 1.08e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 1.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 795 CYAVAVSNDSKLCYFCQSDGVISVWDLHNQSQIRRLQGHGDGASCVDLSATCAQLWTGGLDKTVRNWDIR--EMHRQIAQ 872
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLEtgECVRTLTG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 873 fnFNSQIFSLAKSPTEEWVAAGMESDEIELF-APGRMDRYRLRMHESCVLSLKFAHSGaWFASTGK-DSWLNAWRppwgA 950
Cdd:cd00200   92 --HTSYVSSVAFSPDGRILSSSSRDKTIKVWdVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSqDGTIKLWD----L 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 674574518 951 NLFRVKESL-----SVLSCDISADDRHLVTGSGDRRASIYEIN 988
Cdd:cd00200  165 RTGKCVATLtghtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 685-862 5.52e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 5.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 685 STKVIQTIE-HGEVVCAVMINSSTRHIYTGGK-GTVKLWDLAaataegaptvSKSPLATMDclqgG--NYIRSIKMGQEG 760
Cdd:cd00200  124 TGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQdGTIKLWDLR----------TGKCVATLT----GhtGEVNSVAFSPDG 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 761 NLLVVGGEASVVSIWDMggLTPRPKGEIDIGVQACYAVAVSNDSKLCYFCQSDGVISVWDLHNQSQIRRLQGHGDGASCV 840
Cdd:cd00200  190 EKLLSSSSDGTIKLWDL--STGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267

                        170       180
                 ....*....|....*....|..
gi 674574518 841 DLSATCAQLWTGGLDKTVRNWD 862
Cdd:cd00200  268 AWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
684-894 2.51e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 2.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 684 HSTKVIQTIE-HGEVVCAVMINSSTRHIYTGGK-GTVKLWDLAaataegaptvSKSPLATmdcLQG-GNYIRSIKMGQEG 760
Cdd:COG2319  192 ATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSAdGTVRLWDLA----------TGKLLRT---LTGhSGSVRSVAFSPDG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 761 NLLVVGGEASVVSIWDMGglTPRPKGEIDIGVQACYAVAVSNDSKLCYFCQSDGVISVWDLHNQSQIRRLQGHGDGASCV 840
Cdd:COG2319  259 RLLASGSADGTVRLWDLA--TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 674574518 841 DLSATCAQLWTGGLDKTVRNWDIREMHRQIAQFNFNSQIFSLAKSPTEEWVAAG 894
Cdd:COG2319  337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
685-864 7.53e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 7.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 685 STKVIQTIE-HGEVVCAVMINSSTRHIYTGGK-GTVKLWDLAaataegaptvSKSPLATMDclQGGNYIRSIKMGQEGNL 762
Cdd:COG2319  235 TGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLA----------TGELLRTLT--GHSGGVNSVAFSPDGKL 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 763 LVVGGEASVVSIWDMGglTPRPKGEIDIGVQACYAVAVSNDSKLCYFCQSDGVISVWDLHNQSQIRRLQGHGDGASCVDL 842
Cdd:COG2319  303 LASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                        170       180
                 ....*....|....*....|..
gi 674574518 843 SATCAQLWTGGLDKTVRNWDIR 864
Cdd:COG2319  381 SPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 827-989 4.51e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 4.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 827 IRRLQGHGDGASCVDLSATCAQLWTGGLDKTVRNWDIREMHRQIAQFNFNSQIFSLAKSPTEEWVAAGMESDEIELF-AP 905
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 906 GRMDRYRLRMHESCVLSLKFAHSGAWFASTGKDSWLNAWRPPWGANLFRVKE-SLSVLSCDISADDRHLVTGSGDRRASI 984
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKL 161


                 ....*
gi 674574518 985 YEINY 989
Cdd:cd00200  162 WDLRT 166
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 823-862 3.89e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.89e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 674574518   823 NQSQIRRLQGHGDGASCVDLSATCAQLWTGGLDKTVRNWD 862
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
825-862 1.00e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 674574518  825 SQIRRLQGHGDGASCVDLSATCAQLWTGGLDKTVRNWD 862
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PPE COG5651
PPE-repeat protein [Function unknown];
81-286 2.20e-03

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 41.42  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  81 HRSLQTEISKRLGAIIAQVLPYLPQEHQAQVAAAVERAKQVTLPELNNlisqhQLLFAGANPIGGQLAAAFPPPGIPGLP 160
Cdd:COG5651  180 LLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPG-----NTGFAGTGAAAGAAAAAAAAAAAAGAG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 161 QPPSSTVNGAGTLSSSPAGGVNSLSGTLLSLPGAPPNPFAPPITSASGPNVSTTTPNAGAFLGAPTSTSPGFPNSNLAQS 240
Cdd:COG5651  255 ASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAGAALGAGAAA 334

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 674574518 241 QSAMAAAMAAMAAGLQTNSAAAFGFPNSQTPNSSPAGLAANSLLPN 286
Cdd:COG5651  335 AAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASG 380
PHA03247 PHA03247
large tegument protein UL36; Provisional
 152-440 3.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  152 PPPGIPGLPQPPSsTVNGAGTLSSSPAGGVNSLSGTLLSLPGAPPNPFAPPITSASGpnvSTTTPNAGAflGAPTSTSPG 231
Cdd:PHA03247 2712 PHALVSATPLPPG-PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP---APAPPAAPA--AGPPRRLTR 2785

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  232 FPNSNLAQSQSAMAAAMAAMAAglqtnSAAAFGFPNSQTPNSSPAGLAANsllPNMMSPTAlsalmgdksmdekqraaaa 311
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADP-----PAAVLAPAAALPPAASPAGPLPP---PTSAQPTA------------------- 2838

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518  312 AVAAAMTAAVAQQQCGGLTGVDPTAMMATianmSQSAPGTGFDLSHtacaaaaAAAAAAGVLPPPPPAPAPPQPPSGLPS 391
Cdd:PHA03247 2839 PPPPPGPPPPSLPLGGSVAPGGDVRRRPP----SRSPAAKPAAPAR-------PPVRRLARPAVSRSTESFALPPDQPER 2907

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 674574518  392 APAPLPEVPPTAAAVPPIPPLPSSAEPPRLHSPQALGASSPTQPARASS 440
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
WD40 COG2319
WD40 repeat [General function prediction only];
687-779 4.24e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 4.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674574518 687 KVIQTIE-HGEVVCAVMINSSTRHIYTGGK-GTVKLWDLAaataegaptvSKSPLATmdcLQG-GNYIRSIKMGQEGNLL 763
Cdd:COG2319  321 KLLRTLTgHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLA----------TGELLRT---LTGhTGAVTSVAFSPDGRTL 387

                         90
                 ....*....|....*.
gi 674574518 764 VVGGEASVVSIWDMGG 779
Cdd:COG2319  388 ASGSADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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