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Conserved domains on  [gi|329138862|tpg|DAA07549|]
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TPA: Pat1p [Saccharomyces cerevisiae S288C]

Protein Classification

PAT1 family protein( domain architecture ID 1001013)

PAT1 family protein similar to Saccharomyces cerevisiae DNA topoisomerase 2-associated protein PAT1, an activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation

Gene Ontology:  GO:0003723

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 1-785 9.49e-82

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 279.23  E-value: 9.49e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862    1 MSFFGLENS----------------------GNARDGPLDFEESYKGYGEHELEENDYLNDETFGDNV--------QVGT 50
Cdd:pfam09770   1 MSFFGFDTTlphntaapgfsqahdpfaglsgGDDDDDALDFEDTYDGLGDQLDETGDAFNDDTFGGGGggddvsagPVGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862   51 DFDF-GN------------------PHSSGSSGNAIGGNGVGATARSYVAATAEGISGP-RT--DGTAAAGPL-DLKPME 107
Cdd:pfam09770  81 DFDFfGQtakvsdaieeeqvrfnrqQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPvRTgyEKYKEPEPIpDLQVDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  108 SLWSTapppAMAPSPQSTMAPAPAPQQMAPLQP---ILSMQDLE----------------------------------RQ 150
Cdd:pfam09770 161 SLWGV----APKKAAAPAPAPQPAAQPASLPAPsrkMMSLEEVEaamraqakkpaqqpapapaqppaappaqqaqqqqQF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  151 QRQMQQQFMNFHAMGHPQGLPQGPPQQQFPMQPASGQPGPSQFAPPPPPPGVNVNMNQMPMGPVQV---PVQASPSPIGM 227
Cdd:pfam09770 237 PPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQIlqnPNRLSAARVGY 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  228 SNTPSPGPVVGATKMPLQSGRRSKR------------DLSPEEQRRLQIRHAK----VEKIL---KYSGLMTPRDKDFIT 288
Cdd:pfam09770 317 PQNPQPGVQPAPAHQAHRQQGSFGRqapiithpqqlaQLSEEEKAAYLDEEAKrakrNHKIFllsKDNGLMTPQDKNFIT 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  289 RYQLSQIV----------TEDPYNEDFYFQVYKIIqRGGITSESNKGL--IARAYLEHSGHRLGG---RYKRTDIALQRM 353
Cdd:pfam09770 397 RIQLQQLVsatgnpneqgTDASLSEDFYYQVYSQI-RGGPRQHPSQPLsnFAQTYLFQTGSRQGGmrrQGRGAENHMQRM 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  354 QSQVEKAVTVAKERPsklKDQQAAAGNSsqdnkqantvLGKISSTlNSKNPRRQLQIPRQQPSDPdalkdvtdsltnvdl 433
Cdd:pfam09770 476 EQQVQRAVEAAKNKP---KNKQLVIEGS----------LGKISFS-NAKTPKPLLNIKRPESSND--------------- 526

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  434 assgssstgssaaavasKQRRRSSYafnnGNGATNLNKSGGKKFILELIETVYEEILDLEANLRN-----GQQTDSTAM- 507
Cdd:pfam09770 527 -----------------AHRPGSAK----KQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKmppppTEDSDPELIe 585

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  508 ----------------WEALHIDDS--SYDVNPFISMLSFDKGIKIMPRIFNFLDKQQKLKILQKIFNELSHLQIIilss 569
Cdd:pfam09770 586 khmewrstlqalnaklWQELKVHEPigSTTPHPFIAFLSHPKGKKAIPRIFRHLSQEQRTTILTMIVVHLDQLDVV---- 661

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  570 YKTTPKPTLTQL-----KKVDLFQMIILKIIVSFLsNNSNFIEIMGLLLQLIRNNNVSFLTTSKIGLNLITILISRAALI 644
Cdd:pfam09770 662 RGAQVTDGETQLnaamrEEIELFSQAVMPSLFTYV-NELGLDIVTGLLGLILTRTNVDLIARTRIGLSMLTMILSRAELL 740

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  645 KQdssrSNILSSPEISTWNEIYDKLFTSLESKIQLIFP-PREYNDHImrlqndkfmdeaYIWQFLASLALSGKLN-HQRI 722
Cdd:pfam09770 741 KQ----SGGGTEQDWEQWEQTYNRFFDRLEPTLPYIFPgSVNTGDDV------------YVWQFLAAMGIGASPDqQQRL 804

                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 329138862  723 IIdEVRDEIFATINEAETLqkkEKELSvlpqrSQELdtelksiiynkeklyQDLNLFLNVMGL 785
Cdd:pfam09770 805 VL-AVKDRVMDTVALSKTL---PPDMA-----AQRL---------------GNVNLFMRSIGL 843
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 1-785 9.49e-82

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 279.23  E-value: 9.49e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862    1 MSFFGLENS----------------------GNARDGPLDFEESYKGYGEHELEENDYLNDETFGDNV--------QVGT 50
Cdd:pfam09770   1 MSFFGFDTTlphntaapgfsqahdpfaglsgGDDDDDALDFEDTYDGLGDQLDETGDAFNDDTFGGGGggddvsagPVGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862   51 DFDF-GN------------------PHSSGSSGNAIGGNGVGATARSYVAATAEGISGP-RT--DGTAAAGPL-DLKPME 107
Cdd:pfam09770  81 DFDFfGQtakvsdaieeeqvrfnrqQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPvRTgyEKYKEPEPIpDLQVDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  108 SLWSTapppAMAPSPQSTMAPAPAPQQMAPLQP---ILSMQDLE----------------------------------RQ 150
Cdd:pfam09770 161 SLWGV----APKKAAAPAPAPQPAAQPASLPAPsrkMMSLEEVEaamraqakkpaqqpapapaqppaappaqqaqqqqQF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  151 QRQMQQQFMNFHAMGHPQGLPQGPPQQQFPMQPASGQPGPSQFAPPPPPPGVNVNMNQMPMGPVQV---PVQASPSPIGM 227
Cdd:pfam09770 237 PPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQIlqnPNRLSAARVGY 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  228 SNTPSPGPVVGATKMPLQSGRRSKR------------DLSPEEQRRLQIRHAK----VEKIL---KYSGLMTPRDKDFIT 288
Cdd:pfam09770 317 PQNPQPGVQPAPAHQAHRQQGSFGRqapiithpqqlaQLSEEEKAAYLDEEAKrakrNHKIFllsKDNGLMTPQDKNFIT 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  289 RYQLSQIV----------TEDPYNEDFYFQVYKIIqRGGITSESNKGL--IARAYLEHSGHRLGG---RYKRTDIALQRM 353
Cdd:pfam09770 397 RIQLQQLVsatgnpneqgTDASLSEDFYYQVYSQI-RGGPRQHPSQPLsnFAQTYLFQTGSRQGGmrrQGRGAENHMQRM 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  354 QSQVEKAVTVAKERPsklKDQQAAAGNSsqdnkqantvLGKISSTlNSKNPRRQLQIPRQQPSDPdalkdvtdsltnvdl 433
Cdd:pfam09770 476 EQQVQRAVEAAKNKP---KNKQLVIEGS----------LGKISFS-NAKTPKPLLNIKRPESSND--------------- 526

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  434 assgssstgssaaavasKQRRRSSYafnnGNGATNLNKSGGKKFILELIETVYEEILDLEANLRN-----GQQTDSTAM- 507
Cdd:pfam09770 527 -----------------AHRPGSAK----KQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKmppppTEDSDPELIe 585

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  508 ----------------WEALHIDDS--SYDVNPFISMLSFDKGIKIMPRIFNFLDKQQKLKILQKIFNELSHLQIIilss 569
Cdd:pfam09770 586 khmewrstlqalnaklWQELKVHEPigSTTPHPFIAFLSHPKGKKAIPRIFRHLSQEQRTTILTMIVVHLDQLDVV---- 661

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  570 YKTTPKPTLTQL-----KKVDLFQMIILKIIVSFLsNNSNFIEIMGLLLQLIRNNNVSFLTTSKIGLNLITILISRAALI 644
Cdd:pfam09770 662 RGAQVTDGETQLnaamrEEIELFSQAVMPSLFTYV-NELGLDIVTGLLGLILTRTNVDLIARTRIGLSMLTMILSRAELL 740

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  645 KQdssrSNILSSPEISTWNEIYDKLFTSLESKIQLIFP-PREYNDHImrlqndkfmdeaYIWQFLASLALSGKLN-HQRI 722
Cdd:pfam09770 741 KQ----SGGGTEQDWEQWEQTYNRFFDRLEPTLPYIFPgSVNTGDDV------------YVWQFLAAMGIGASPDqQQRL 804

                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 329138862  723 IIdEVRDEIFATINEAETLqkkEKELSvlpqrSQELdtelksiiynkeklyQDLNLFLNVMGL 785
Cdd:pfam09770 805 VL-AVKDRVMDTVALSKTL---PPDMA-----AQRL---------------GNVNLFMRSIGL 843
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 1-785 9.49e-82

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 279.23  E-value: 9.49e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862    1 MSFFGLENS----------------------GNARDGPLDFEESYKGYGEHELEENDYLNDETFGDNV--------QVGT 50
Cdd:pfam09770   1 MSFFGFDTTlphntaapgfsqahdpfaglsgGDDDDDALDFEDTYDGLGDQLDETGDAFNDDTFGGGGggddvsagPVGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862   51 DFDF-GN------------------PHSSGSSGNAIGGNGVGATARSYVAATAEGISGP-RT--DGTAAAGPL-DLKPME 107
Cdd:pfam09770  81 DFDFfGQtakvsdaieeeqvrfnrqQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPvRTgyEKYKEPEPIpDLQVDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  108 SLWSTapppAMAPSPQSTMAPAPAPQQMAPLQP---ILSMQDLE----------------------------------RQ 150
Cdd:pfam09770 161 SLWGV----APKKAAAPAPAPQPAAQPASLPAPsrkMMSLEEVEaamraqakkpaqqpapapaqppaappaqqaqqqqQF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  151 QRQMQQQFMNFHAMGHPQGLPQGPPQQQFPMQPASGQPGPSQFAPPPPPPGVNVNMNQMPMGPVQV---PVQASPSPIGM 227
Cdd:pfam09770 237 PPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQIlqnPNRLSAARVGY 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  228 SNTPSPGPVVGATKMPLQSGRRSKR------------DLSPEEQRRLQIRHAK----VEKIL---KYSGLMTPRDKDFIT 288
Cdd:pfam09770 317 PQNPQPGVQPAPAHQAHRQQGSFGRqapiithpqqlaQLSEEEKAAYLDEEAKrakrNHKIFllsKDNGLMTPQDKNFIT 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  289 RYQLSQIV----------TEDPYNEDFYFQVYKIIqRGGITSESNKGL--IARAYLEHSGHRLGG---RYKRTDIALQRM 353
Cdd:pfam09770 397 RIQLQQLVsatgnpneqgTDASLSEDFYYQVYSQI-RGGPRQHPSQPLsnFAQTYLFQTGSRQGGmrrQGRGAENHMQRM 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  354 QSQVEKAVTVAKERPsklKDQQAAAGNSsqdnkqantvLGKISSTlNSKNPRRQLQIPRQQPSDPdalkdvtdsltnvdl 433
Cdd:pfam09770 476 EQQVQRAVEAAKNKP---KNKQLVIEGS----------LGKISFS-NAKTPKPLLNIKRPESSND--------------- 526

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  434 assgssstgssaaavasKQRRRSSYafnnGNGATNLNKSGGKKFILELIETVYEEILDLEANLRN-----GQQTDSTAM- 507
Cdd:pfam09770 527 -----------------AHRPGSAK----KQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKmppppTEDSDPELIe 585

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  508 ----------------WEALHIDDS--SYDVNPFISMLSFDKGIKIMPRIFNFLDKQQKLKILQKIFNELSHLQIIilss 569
Cdd:pfam09770 586 khmewrstlqalnaklWQELKVHEPigSTTPHPFIAFLSHPKGKKAIPRIFRHLSQEQRTTILTMIVVHLDQLDVV---- 661

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  570 YKTTPKPTLTQL-----KKVDLFQMIILKIIVSFLsNNSNFIEIMGLLLQLIRNNNVSFLTTSKIGLNLITILISRAALI 644
Cdd:pfam09770 662 RGAQVTDGETQLnaamrEEIELFSQAVMPSLFTYV-NELGLDIVTGLLGLILTRTNVDLIARTRIGLSMLTMILSRAELL 740

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329138862  645 KQdssrSNILSSPEISTWNEIYDKLFTSLESKIQLIFP-PREYNDHImrlqndkfmdeaYIWQFLASLALSGKLN-HQRI 722
Cdd:pfam09770 741 KQ----SGGGTEQDWEQWEQTYNRFFDRLEPTLPYIFPgSVNTGDDV------------YVWQFLAAMGIGASPDqQQRL 804

                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 329138862  723 IIdEVRDEIFATINEAETLqkkEKELSvlpqrSQELdtelksiiynkeklyQDLNLFLNVMGL 785
Cdd:pfam09770 805 VL-AVKDRVMDTVALSKTL---PPDMA-----AQRL---------------GNVNLFMRSIGL 843
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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