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Conserved domains on  [gi|2245399233|sp|E9FR69|]
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RecName: Full=Iodotyrosine deiodinase; AltName: Full=Halotyrosine dehalogenase

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 103-295 2.58e-125

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


:

Pssm-ID: 380320  Cd Length: 192  Bit Score: 355.31  E-value: 2.58e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 103 FYRRMNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIIEAEEEINYKQRMGDVWVQD 182
Cdd:cd02144     1 FYELMKKRRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKRKIREAAEEEEKEFYEKRMGEEWVWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 183 LQPVGTTWVKEYLTEAPWLILIFKQVHGFKRNGQKKIHYYNEISVSIATGFLLAAIQEAGLVTVTTTPLNcGPSIRVLLG 262
Cdd:cd02144    81 LKPLGTNWEKPYLTEAPYLIVVFKQKYGVLPDGKKKKHYYNEESVGIAVGILLAALHNAGLVTLTHTPSP-MPFLRDLLG 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2245399233 263 RPVNEKLLLLLPVGYPKVGATVPDFKRKPLHDI 295
Cdd:cd02144   160 RPKNEKPLLLLPVGYPAEDATVPDLKRKPLEEI 192
 
Name Accession Description Interval E-value
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 103-295 2.58e-125

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 355.31  E-value: 2.58e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 103 FYRRMNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIIEAEEEINYKQRMGDVWVQD 182
Cdd:cd02144     1 FYELMKKRRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKRKIREAAEEEEKEFYEKRMGEEWVWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 183 LQPVGTTWVKEYLTEAPWLILIFKQVHGFKRNGQKKIHYYNEISVSIATGFLLAAIQEAGLVTVTTTPLNcGPSIRVLLG 262
Cdd:cd02144    81 LKPLGTNWEKPYLTEAPYLIVVFKQKYGVLPDGKKKKHYYNEESVGIAVGILLAALHNAGLVTLTHTPSP-MPFLRDLLG 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2245399233 263 RPVNEKLLLLLPVGYPKVGATVPDFKRKPLHDI 295
Cdd:cd02144   160 RPKNEKPLLLLPVGYPAEDATVPDLKRKPLEEI 192
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 103-295 1.12e-27

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 104.94  E-value: 1.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 103 FYRRMNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRqiiEAEEEINykqrmgdvwvqd 182
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLA---EALAEAN------------ 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 183 lqpvgttwvKEYLTEAPWLILIFKQvhgfKRNGQKKIHYYNEISVSIATGFLLAAIQEAGLVTVTTTPLNcGPSIRVLLG 262
Cdd:COG0778    66 ---------QEWVADAPVLIVVCAD----PDRSEKVPERYALLDAGIAAQNLLLAARALGLGTCWIGGFD-PEKVRELLG 131

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2245399233 263 RPVNEKLLLLLPVGYPKvgATVPDFKRKPLHDI 295
Cdd:COG0778   132 LPEGEEPVALLALGYPA--EELNPRPRKPLEEV 162
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 109-277 1.16e-21

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 89.37  E-value: 1.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 109 QRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIieAEEEINYKQRMGDVWVQDLQPVGT 188
Cdd:pfam00881   3 QRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEA--ALELLLVEPAAALLLLLRRDANLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 189 TWVKEYLTEAPWLILIFKQVHGFKRNGQKKIHYYNEISVSIATG-FLLAAiQEAGLVTVTTTPLNcGPSIRVLLGRPVNE 267
Cdd:pfam00881  81 LLLQDFLRGAPVLIVITASLSTYLRKAAERAYREALLDAGAAAQnLLLAA-TSLGLGSCPIGGFD-AAAVRELLGLPDDE 158

                         170
                  ....*....|
gi 2245399233 268 KLLLLLPVGY 277
Cdd:pfam00881 159 RLVGLIAVGY 168
PRK13294 PRK13294
F420-0--gamma-glutamyl ligase; Provisional
 109-178 7.56e-07

F420-0--gamma-glutamyl ligase; Provisional


Pssm-ID: 183957 [Multi-domain]  Cd Length: 448  Bit Score: 50.01  E-value: 7.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 109 QRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLE--------MKQQIRQIIEA----EEEINYKQRMG 176
Cdd:PRK13294  259 LRRSVREFSDDPVDPEAVRRAVAAALTAPAPHHTRPVRFVWLRSAAvrtrlldaMRDAWRADLRAdglsEESIARRVRRG 338


                  ..
gi 2245399233 177 DV 178
Cdd:PRK13294  339 DI 340
 
Name Accession Description Interval E-value
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 103-295 2.58e-125

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 355.31  E-value: 2.58e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 103 FYRRMNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIIEAEEEINYKQRMGDVWVQD 182
Cdd:cd02144     1 FYELMKKRRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKRKIREAAEEEEKEFYEKRMGEEWVWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 183 LQPVGTTWVKEYLTEAPWLILIFKQVHGFKRNGQKKIHYYNEISVSIATGFLLAAIQEAGLVTVTTTPLNcGPSIRVLLG 262
Cdd:cd02144    81 LKPLGTNWEKPYLTEAPYLIVVFKQKYGVLPDGKKKKHYYNEESVGIAVGILLAALHNAGLVTLTHTPSP-MPFLRDLLG 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2245399233 263 RPVNEKLLLLLPVGYPKVGATVPDFKRKPLHDI 295
Cdd:cd02144   160 RPKNEKPLLLLPVGYPAEDATVPDLKRKPLEEI 192
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 103-295 1.12e-27

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 104.94  E-value: 1.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 103 FYRRMNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRqiiEAEEEINykqrmgdvwvqd 182
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLA---EALAEAN------------ 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 183 lqpvgttwvKEYLTEAPWLILIFKQvhgfKRNGQKKIHYYNEISVSIATGFLLAAIQEAGLVTVTTTPLNcGPSIRVLLG 262
Cdd:COG0778    66 ---------QEWVADAPVLIVVCAD----PDRSEKVPERYALLDAGIAAQNLLLAARALGLGTCWIGGFD-PEKVRELLG 131

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2245399233 263 RPVNEKLLLLLPVGYPKvgATVPDFKRKPLHDI 295
Cdd:COG0778   132 LPEGEEPVALLALGYPA--EELNPRPRKPLEEV 162
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 109-277 1.16e-21

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 89.37  E-value: 1.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 109 QRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIieAEEEINYKQRMGDVWVQDLQPVGT 188
Cdd:pfam00881   3 QRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEA--ALELLLVEPAAALLLLLRRDANLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 189 TWVKEYLTEAPWLILIFKQVHGFKRNGQKKIHYYNEISVSIATG-FLLAAiQEAGLVTVTTTPLNcGPSIRVLLGRPVNE 267
Cdd:pfam00881  81 LLLQDFLRGAPVLIVITASLSTYLRKAAERAYREALLDAGAAAQnLLLAA-TSLGLGSCPIGGFD-AAAVRELLGLPDDE 158

                         170
                  ....*....|
gi 2245399233 268 KLLLLLPVGY 277
Cdd:pfam00881 159 RLVGLIAVGY 168
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 107-277 5.99e-20

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 83.89  E-value: 5.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 107 MNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQiieaeeEINYKQRMgdvwvqdlqpv 186
Cdd:cd02062     1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAK------LAAPNQKF----------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 187 gttwvkeyLTEAPWLILIFKQvhgfkrngQKKIHYYNEISVSIATGFLLAAIQEAGLVTVTTTPLNCGPS-IRVLLGRPV 265
Cdd:cd02062    64 --------IAGAPVVIVVVAD--------PDKSRPWALEDAGAAAQNLLLAAAALGLGSCWIGGFDFREDkVRELLGIPE 127

                         170
                  ....*....|..
gi 2245399233 266 NEKLLLLLPVGY 277
Cdd:cd02062   128 NLRPVALIAIGY 139
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 110-277 2.94e-16

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 74.62  E-value: 2.94e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 110 RRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIIEAEEEINYKQRMGDVWVQDLQPVGTT 189
Cdd:cd20610     4 RRSIRKFKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIEKIGISIKKKNEEIARLLEKVFAEKPIRFRKFR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 190 WVKEYLTEAPWLILIFKQVHgfkrngqKKIHYYNEI--SVSIAT-GFLLAAIQEaGLVTV-TTTPLNCGPSIRVLLGRPV 265
Cdd:cd20610    84 RFFTLFGGAPVLVVVYTEPY-------KPPEERKPDlqSVSAAIqNLLLAAHAL-GLGTCwMTGPLYAEDEIEEILEIPD 155

                         170
                  ....*....|..
gi 2245399233 266 NEKLLLLLPVGY 277
Cdd:cd20610   156 DKELVAVTPLGY 167
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 108-294 4.02e-12

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 62.99  E-value: 4.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 108 NQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNlemkqqirqiiEAEEEInyKQRMGDVwvqdlqPVG 187
Cdd:cd02136     3 KSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTG-----------KARERL--KKAFFGA------PVA 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 188 ttwvkeylteapwLILIFKQVHGFkrngqkkihyYNEISVSIATG-FLLAAiQEAGLVTVtttPLNCGPS----IRVLLG 262
Cdd:cd02136    64 -------------LFLTMDKVLGP----------WSWFDLGAFLQnLMLAA-HALGLGTC---PQGALAGypdvVRKELG 116

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2245399233 263 RPVNEKLLLLLPVGYPKVGATVPDFKRKPLHD 294
Cdd:cd02136   117 IPDDEELVCGIALGYPDPDAPVNQFRTPREPL 148
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 103-299 1.02e-11

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 62.10  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 103 FYRRMNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIIEAeeeinykqrmgdvwvqd 182
Cdd:cd02139     1 VYEAIKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKEKLAEAANG----------------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 183 lqpvgttwvKEYLTEAPWLI-LIFKQVHGFKRNGQKkihyYNEISVSIATGFL-LAAIQEaGLVTvtttplnC------G 254
Cdd:cd02139    64 ---------QKFIAEAPVVIvACADPSESGMGCGKP----YYLVDVAIAMEHLvLAATEE-GLGT-------CwigafdE 122

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2245399233 255 PSIRVLLGRPVNEKLLLLLPVGYPKVgaTVPDFKRKPLHDImVHY 299
Cdd:cd02139   123 DKVKEILGIPEEYRVVALTPLGYPAE--EPPPRPRKPLEEI-VFY 164
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 107-291 4.32e-11

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 60.24  E-value: 4.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 107 MNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNlemKQQIRQIIEAEeeinykqrmgdvwvqdlqPV 186
Cdd:cd02151     3 LKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVDD---KETLKKLSECK------------------PH 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 187 GTTWVKeyltEAPWLILIFKQvhgfkrngQKKIHYYNEISvSIATGFLLAAIQEAGL----VTVTTTPLNCGPS----IR 258
Cdd:cd02151    62 GSAFLK----GAPAAIVVLAD--------TEKSDTWIEDA-SIAATYIQLAAESLGLgscwIQIRNRETQDGKTaeeyVR 128

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2245399233 259 VLLGRPVNEKLLLLLPVGYpkvgatvPDFKRKP 291
Cdd:cd02151   129 ELLGIPENYRVLCIIALGY-------PDEEKPP 154
BluB cd02145
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ...
 104-290 7.36e-11

5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.


Pssm-ID: 380321  Cd Length: 196  Bit Score: 60.45  E-value: 7.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 104 YRRMNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIIEAeeeinYKQRMGDVWVQDL 183
Cdd:cd02145     1 YRVIRWRRDVRHFRPDPVPEEVLERLLQAAHLAPSVGLMQPWRFVRVRSAATRKAVHELFQR-----ANAEAAEMYTGER 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 184 QPVGTTWVKEYLTEAPWLILIF-----KQVHGFKRNGQKKIHYYNeiSVSIATGFLLAAIQE---AGLVTVtttpLNcgP 255
Cdd:cd02145    76 AAQYRTLKLEGIEEAPLQLAVFcdrarAGGHGLGRTTMPEMDLYS--SVCAVQNLWLAARAEglgVGWVSI----LD--P 147

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2245399233 256 S-IRVLLGRPVNEKLLLLLPVGYPKVGATVPDFKRK 290
Cdd:cd02145   148 DeVKRLLGIPEHWEPVAYLCIGYPEFFYDEPELEQA 183
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 110-277 1.11e-10

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 58.50  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 110 RRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNlemKQQIRQIIEAEEEINykqrmgdvwvqdlqpvgtt 189
Cdd:cd20608     7 RRSVRRFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVTD---KETLSELAKKESPSN------------------- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 190 wvkEYLTEAPWLI-LIFKQVHGFKRNGQKkihyYNEISVSIATGFLLAAIQEAGLVTVTTTPLNcGPSIRVLLGRPVNEK 268
Cdd:cd20608    65 ---GWLKDAPVIIvVCADPKDSGWLNGQN----YYLVDAAIAMQNLMLAATDLGLGTCWIGAFD-EKKVKEILGIPENIR 136


                  ....*....
gi 2245399233 269 LLLLLPVGY 277
Cdd:cd20608   137 VVALTPLGY 145
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 110-280 1.32e-10

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 58.77  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 110 RRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIieaeeeinykqrmgdvwvqdlQPVGtt 189
Cdd:cd02150     4 RRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKLDKIAEA---------------------HPYG-- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 190 wvkEYLTEAPWLILIfkqvhgfkrNGQKKIHYYNEISV---SIATGFLLAAIQEAGLVTVTTtplNCGPS------IRVL 260
Cdd:cd02150    61 ---KMLKEAPLAIVV---------CGDPSKEKAPGYWVqdcSAATENILLAAHALGLGAVWL---GVYPFeervkaIREI 125

                         170       180
                  ....*....|....*....|
gi 2245399233 261 LGRPVNEKLLLLLPVGYPKV 280
Cdd:cd02150   126 LNIPENIIPFCVIALGYPAE 145
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 110-278 2.24e-10

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 58.87  E-value: 2.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 110 RRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIR-------QIIEA----------EEEINyk 172
Cdd:cd03370     8 RRSIRKYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQaaaygqaQVTSApaviviysdmEDALA-- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 173 qRMGDVWVQDLQPVGTTWVKEYLTEApwlilifkqvhgFKRNGQKKIHYYNEISVSIATGFLLAAIQEAGLVTVTTtpLN 252
Cdd:cd03370    86 -NLEETIHPGLSEERRQREAAGLRGA------------FGKMSVEQRGQWGLAQANIALGFLLLAAQSLGYDTSPM--LG 150

                         170       180
                  ....*....|....*....|....*..
gi 2245399233 253 CGPS-IRVLLGRPVNEKLLLLLPVGYP 278
Cdd:cd03370   151 FDPEkVKALLGLPEHVTIAALVALGKP 177
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 110-277 1.76e-08

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 52.99  E-value: 1.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 110 RRSVREISSD-PVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIIEA--EEEINYKQRMGDVWvqdlqpv 186
Cdd:cd02135     7 RRSIRKFKLTgAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRERLAELLAAAaaARAPGADPEKLEKA------- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 187 gttwvKEYLTEAPWLILIfkqvhGFKRNGQKKIHYYNEI-SVSIAT-GFLLAAiQEAGLVTV-TTTPLNCGPSIRVLLGR 263
Cdd:cd02135    80 -----REKALRAPVVIAV-----VAKPDEDPKVPEWEQYaAVGAAVqNLLLAA-HALGLGAVwRTGPVTYDPAVREALGL 148

                         170
                  ....*....|....
gi 2245399233 264 PVNEKLLLLLPVGY 277
Cdd:cd02135   149 PEDERIVGFLYLGT 162
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 102-277 1.04e-07

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 50.08  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 102 EFYRRMNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIieaeeeinYKqrmgdvwvq 181
Cdd:cd20609     1 DFLELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKA--------TP--------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 182 dlqpvgttwvkeYLTEAPwLILIFKQVH--GFKRNGQKKIHYynEISVSIATGFLLAAIQEAGLVT--VtttplnCG--- 254
Cdd:cd20609    64 ------------RFFGAP-LVIVVCYDKdeSWKRPYDGKDSG--DIDAAIVATHMMLAATELGLGTcwV------GNfdp 122

                         170       180
                  ....*....|....*....|...
gi 2245399233 255 PSIRVLLGRPVNEKLLLLLPVGY 277
Cdd:cd20609   123 EKVREAFNLPENLEPVAILPLGY 145
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 107-295 5.93e-07

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 48.01  E-value: 5.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 107 MNQRRSVREISSD-PVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIIeaeeeINYKQrmgdvwvqdlqp 185
Cdd:cd02137     4 IKSRRSVRNFDPDhKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAA-----YNQPQ------------ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 186 vgttwvkeyLTEAPWLILIFKQvhgfkrngqkkihyyneISVSIATGFLLAAIQEAGLVTVTTTPLNcGPSIRVLLGRPV 265
Cdd:cd02137    67 ---------VTTASAVILVLGD-----------------LNAGLAAMNLMLAAKAKGYDTCPMGGFD-KEKVAELLNLPD 119

                         170       180       190
                  ....*....|....*....|....*....|
gi 2245399233 266 NEKLLLLLPVGYPKVGAtvPDFKRKPLHDI 295
Cdd:cd02137   120 RYVPVLLIAIGKAADKA--PRSGRLPVDEV 147
PRK13294 PRK13294
F420-0--gamma-glutamyl ligase; Provisional
 109-178 7.56e-07

F420-0--gamma-glutamyl ligase; Provisional


Pssm-ID: 183957 [Multi-domain]  Cd Length: 448  Bit Score: 50.01  E-value: 7.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 109 QRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLE--------MKQQIRQIIEA----EEEINYKQRMG 176
Cdd:PRK13294  259 LRRSVREFSDDPVDPEAVRRAVAAALTAPAPHHTRPVRFVWLRSAAvrtrlldaMRDAWRADLRAdglsEESIARRVRRG 338


                  ..
gi 2245399233 177 DV 178
Cdd:PRK13294  339 DI 340
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 107-162 4.51e-06

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 45.71  E-value: 4.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2245399233 107 MNQRRSVREI-SSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQI 162
Cdd:cd02149     6 LNFRYATKKFdPNKKISDEDLETILEALRLSPSSFGLEPWKFLVVENPELKAKLAPA 62
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 110-164 1.09e-04

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 42.07  E-value: 1.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2245399233 110 RRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNlemKQQIRQIIE 164
Cdd:cd02143     5 RRSIRRYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVVDD---PEKVRRLAE 56
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 110-245 4.82e-04

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 40.22  E-value: 4.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245399233 110 RRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVvsnlemkqqirqiieAEEEINYKQRMGDVwvqdLQPVGTT 189
Cdd:cd02138     5 RWSPRAFSPEPISEEDLLSLFEAARWAPSCFNEQPWRFVV---------------ARRDTEAFEKLLDL----LAEGNQS 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2245399233 190 WVKeyltEAPWLILIFKQVHgFKRNGqkKIHYYNEISVSIATGFLLAAIQEAGLVT 245
Cdd:cd02138    66 WAK----NAPVLIVVLAKTE-FDHNG--KPNRYALFDTGAAVANLALQATALGLVV 114
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 107-162 5.97e-04

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 40.30  E-value: 5.97e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2245399233 107 MNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQI 162
Cdd:cd02146     5 ILNHRSVRKFTDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELREKLAEL 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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