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Conserved domains on  [gi|119572635|gb|EAW52250|]
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zinc finger protein 553, isoform CRA_a [Homo sapiens]

Protein Classification

zf-H2C2_2 and COG5048 domain-containing protein( domain architecture ID 11779706)

protein containing domains SFP1, zf-H2C2_2, and COG5048

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-600 2.25e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 190 RPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCG--ICGKGFGDSSARIKHQRTHrGEQPPRPVVPRRQPSRAATAATQG 267
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH-HNNPSDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 268 PKAQDKPYICTDCgkrfvlSCSLLSHQRSHlgpkPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC-------PECGKGF 340
Cdd:COG5048  111 SSSSSNSNDNNLL------SSHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpaNSLSKDP 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 341 ADSSARVKHLRTHSGERPHACPecdrTFSLSSTLLRHRLTHMEPQDFSFPGLFPYPLLIPSPPPPPLGTSPPLTPRSPSH 420
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSEN----SPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 421 SGEPFGLPGLEPEPG--GPQAGEPPPPLAGDKPHKCPECGKGFRRSSDLVKH--HRVHTGE--KPYLCPE--CGKGFADS 492
Cdd:COG5048  257 ASESPRSSLPTASSQssSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 493 SARVKHLRTHRGERARPPPPSTLLRPHNPPGPvpmaPRPRVRAQPSG---PSQPHVC--GFCGKEFPRSSDLVKHRRTHT 567
Cdd:COG5048  337 DALKRHILLHTSISPAKEKLLNSSSKFSPLLN----NEPPQSLQQYKdlkNDKKSETlsNSCIRNFKRDSNLSLHIITHL 412

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 119572635 568 GEKP--YKCAECGKGFGDSSARIKHQRGHLVLTPF 600
Cdd:COG5048  413 SFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
zf-H2C2_2 pfam13465
Zinc-finger double domain;
126-149 1.24e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....
gi 119572635  126 DLVKHQRTHTGEKPYKCGVCGKGF 149
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 51-215 1.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635  51 FKEEDLAPDHEVgnaSLKPEGIQNWDDlwvqreglgkPQPRDRGPRLLGEPRWGQASSDRAAVCGEcgksfRQMSDLVKH 130
Cdd:COG5189  280 FEESSLGFDYEF---IHKSVGNKEIRG----------GISTGEMIDVRKLPCTNSSSNGKLAHGGE-----RNIDTPSRM 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 131 QRThTGEKPYKCGV--CGKGFGDSSArIKHQRTHSGEKPYRARPPAQgppkIPRSRIPAGERPTICGECGKSFRQSSDLv 208
Cdd:COG5189  342 LKV-KDGKPYKCPVegCNKKYKNQNG-LKYHMLHGHQNQKLHENPSP----EKMNIFSAKDKPYRCEVCDKRYKNLNGL- 414


                 ....*..
gi 119572635 209 KHQRTHT 215
Cdd:COG5189  415 KYHRKHS 421
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-600 2.25e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 190 RPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCG--ICGKGFGDSSARIKHQRTHrGEQPPRPVVPRRQPSRAATAATQG 267
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH-HNNPSDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 268 PKAQDKPYICTDCgkrfvlSCSLLSHQRSHlgpkPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC-------PECGKGF 340
Cdd:COG5048  111 SSSSSNSNDNNLL------SSHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpaNSLSKDP 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 341 ADSSARVKHLRTHSGERPHACPecdrTFSLSSTLLRHRLTHMEPQDFSFPGLFPYPLLIPSPPPPPLGTSPPLTPRSPSH 420
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSEN----SPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 421 SGEPFGLPGLEPEPG--GPQAGEPPPPLAGDKPHKCPECGKGFRRSSDLVKH--HRVHTGE--KPYLCPE--CGKGFADS 492
Cdd:COG5048  257 ASESPRSSLPTASSQssSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 493 SARVKHLRTHRGERARPPPPSTLLRPHNPPGPvpmaPRPRVRAQPSG---PSQPHVC--GFCGKEFPRSSDLVKHRRTHT 567
Cdd:COG5048  337 DALKRHILLHTSISPAKEKLLNSSSKFSPLLN----NEPPQSLQQYKdlkNDKKSETlsNSCIRNFKRDSNLSLHIITHL 412

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 119572635 568 GEKP--YKCAECGKGFGDSSARIKHQRGHLVLTPF 600
Cdd:COG5048  413 SFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-581 7.80e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.80e-05
                          10        20
                  ....*....|....*....|....
gi 119572635  558 DLVKHRRTHTGEKPYKCAECGKGF 581
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
126-149 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....
gi 119572635  126 DLVKHQRTHTGEKPYKCGVCGKGF 149
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 51-215 1.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635  51 FKEEDLAPDHEVgnaSLKPEGIQNWDDlwvqreglgkPQPRDRGPRLLGEPRWGQASSDRAAVCGEcgksfRQMSDLVKH 130
Cdd:COG5189  280 FEESSLGFDYEF---IHKSVGNKEIRG----------GISTGEMIDVRKLPCTNSSSNGKLAHGGE-----RNIDTPSRM 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 131 QRThTGEKPYKCGV--CGKGFGDSSArIKHQRTHSGEKPYRARPPAQgppkIPRSRIPAGERPTICGECGKSFRQSSDLv 208
Cdd:COG5189  342 LKV-KDGKPYKCPVegCNKKYKNQNG-LKYHMLHGHQNQKLHENPSP----EKMNIFSAKDKPYRCEVCDKRYKNLNGL- 414


                 ....*..
gi 119572635 209 KHQRTHT 215
Cdd:COG5189  415 KYHRKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 113-134 1.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|..
gi 119572635  113 VCGECGKSFRQMSDLVKHQRTH 134
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-571 2.51e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635  429 GLEpEPGGPQAGEPPPPLAGDKPHKCPE----CGKGFRRSSDLVKHHRVHtgeKPYLCPEcgkgfadsSARVKHLRTHRG 504
Cdd:PHA03247 2539 GLE-ELASDDAGDPPPPLPPAAPPAAPDrsvpPPRPAPRPSEPAVTSRAR---RPDAPPQ--------SARPRAPVDDRG 2606

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119572635  505 ERARPPPPSTLLRPHNPPGPVPMAPRPRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRTHTGEKP 571
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA 2673
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-600 2.25e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 190 RPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCG--ICGKGFGDSSARIKHQRTHrGEQPPRPVVPRRQPSRAATAATQG 267
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH-HNNPSDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 268 PKAQDKPYICTDCgkrfvlSCSLLSHQRSHlgpkPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC-------PECGKGF 340
Cdd:COG5048  111 SSSSSNSNDNNLL------SSHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpaNSLSKDP 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 341 ADSSARVKHLRTHSGERPHACPecdrTFSLSSTLLRHRLTHMEPQDFSFPGLFPYPLLIPSPPPPPLGTSPPLTPRSPSH 420
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSEN----SPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 421 SGEPFGLPGLEPEPG--GPQAGEPPPPLAGDKPHKCPECGKGFRRSSDLVKH--HRVHTGE--KPYLCPE--CGKGFADS 492
Cdd:COG5048  257 ASESPRSSLPTASSQssSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 493 SARVKHLRTHRGERARPPPPSTLLRPHNPPGPvpmaPRPRVRAQPSG---PSQPHVC--GFCGKEFPRSSDLVKHRRTHT 567
Cdd:COG5048  337 DALKRHILLHTSISPAKEKLLNSSSKFSPLLN----NEPPQSLQQYKdlkNDKKSETlsNSCIRNFKRDSNLSLHIITHL 412

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 119572635 568 GEKP--YKCAECGKGFGDSSARIKHQRGHLVLTPF 600
Cdd:COG5048  413 SFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
114-500 8.69e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 8.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 114 CGECGKSFRQMSDLVKHQRTHTGEKPYKCGV--CGKGFGDSSARIKHQRTH----------------------------- 162
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHhnnpsdlnskslplsnskasssslsssss 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 163 -------------SGEKPYRARPPAQGPPKIPRSRIPAGERPTICGE--------------CGKSFRQSSDLVKHQRTHT 215
Cdd:COG5048  116 nsndnnllsshslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslSKDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 216 GEKPYKCGicgkgFGDSSARIKHQRTHRGEQPPRPVVPRRQPS--RAATAATQGPKAQDKPYICTDCGKRFVLS-----C 288
Cdd:COG5048  196 IPSSSENS-----PLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlSPKSLLSQSPSSLSSSDSSSSASESPRSSlptasS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 289 SLLSHQRSHLGP-----KPFGCDVCGKEFARGSDLVKHLR--VHTGE--KPYLCPE--CGKGFADSSARVKHLRTHSGER 357
Cdd:COG5048  271 QSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 358 PHACPECDRTFSLSStllrhrLTHMEPQDFSFPglfpypllipsppppplgtsppLTPRSPSHSGEPFGLPGLEPEPGGP 437
Cdd:COG5048  351 PAKEKLLNSSSKFSP------LLNNEPPQSLQQ----------------------YKDLKNDKKSETLSNSCIRNFKRDS 402

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119572635 438 QAGEPPPPLAGDKPH--KCPECGKGFRRSSDLVKHHRVHTgEKPYLCPECGKGFADSSARVKHLR 500
Cdd:COG5048  403 NLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-600 9.88e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 9.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 300 PKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC--PECGKGFADSSARVKHLRTHSGERPHAC--PECDRTFSLSSTLL 375
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 376 R--------------HRLTHMEPQDFSFPGLFPY--PLLIPSPPPPPLGTSPPLTPRSPSHSGEPFGLPGLEPEPGGPQA 439
Cdd:COG5048  111 SssssnsndnnllssHSLPPSSRDPQLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 440 GEPPPPlagdKPHKCPECGKGFRRSSDLVKHHRVHTGEKPYLCPECGKGFADSSarVKHLRTHRGERARPPPPSTLLRPH 519
Cdd:COG5048  191 NVSTSI----PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 520 NPPGPVPMA-PRPRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRT--HTGE--KPYKCAE--CGKGFGDSSARIKHQR 592
Cdd:COG5048  265 LPTASSQSSsPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344


                 ....*...
gi 119572635 593 GHLVLTPF 600
Cdd:COG5048  345 LHTSISPA 352
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-581 7.80e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.80e-05
                          10        20
                  ....*....|....*....|....
gi 119572635  558 DLVKHRRTHTGEKPYKCAECGKGF 581
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
317-341 8.11e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.11e-05
                          10        20
                  ....*....|....*....|....*
gi 119572635  317 DLVKHLRVHTGEKPYLCPECGKGFA 341
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 452-474 1.18e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 1.18e-04
                          10        20
                  ....*....|....*....|...
gi 119572635  452 HKCPECGKGFRRSSDLVKHHRVH 474
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
126-149 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....
gi 119572635  126 DLVKHQRTHTGEKPYKCGVCGKGF 149
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
206-229 1.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.85e-04
                          10        20
                  ....*....|....*....|....
gi 119572635  206 DLVKHQRTHTGEKPYKCGICGKGF 229
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
466-490 2.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.66e-04
                          10        20
                  ....*....|....*....|....*
gi 119572635  466 DLVKHHRVHTGEKPYLCPECGKGFA 490
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 194-214 4.29e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 4.29e-04
                          10        20
                  ....*....|....*....|.
gi 119572635  194 CGECGKSFRQSSDLVKHQRTH 214
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 216-284 4.92e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 4.92e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119572635 216 GEKPYKCGI--CGKGFGDSSArIKHQRTHRGEQPPRPVVPRRQPsraataaTQGPKAQDKPYICTDCGKRF 284
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNG-LKYHMLHGHQNQKLHENPSPEK-------MNIFSAKDKPYRCEVCDKRY 408
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
525-592 6.10e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 6.10e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 525 VPMAPRPRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRTHTGEKPYKCA--ECGKGFGDSSARIKHQR 592
Cdd:COG5048   15 VLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLR 84
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-369 7.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.45e-04
                          10        20
                  ....*....|....*....|..
gi 119572635  348 KHLRTHSGERPHACPECDRTFS 369
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 51-215 1.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635  51 FKEEDLAPDHEVgnaSLKPEGIQNWDDlwvqreglgkPQPRDRGPRLLGEPRWGQASSDRAAVCGEcgksfRQMSDLVKH 130
Cdd:COG5189  280 FEESSLGFDYEF---IHKSVGNKEIRG----------GISTGEMIDVRKLPCTNSSSNGKLAHGGE-----RNIDTPSRM 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635 131 QRThTGEKPYKCGV--CGKGFGDSSArIKHQRTHSGEKPYRARPPAQgppkIPRSRIPAGERPTICGECGKSFRQSSDLv 208
Cdd:COG5189  342 LKV-KDGKPYKCPVegCNKKYKNQNG-LKYHMLHGHQNQKLHENPSP----EKMNIFSAKDKPYRCEVCDKRYKNLNGL- 414


                 ....*..
gi 119572635 209 KHQRTHT 215
Cdd:COG5189  415 KYHRKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 113-134 1.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|..
gi 119572635  113 VCGECGKSFRQMSDLVKHQRTH 134
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 544-566 1.81e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.81e-03
                          10        20
                  ....*....|....*....|...
gi 119572635  544 HVCGFCGKEFPRSSDLVKHRRTH 566
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-571 2.51e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119572635  429 GLEpEPGGPQAGEPPPPLAGDKPHKCPE----CGKGFRRSSDLVKHHRVHtgeKPYLCPEcgkgfadsSARVKHLRTHRG 504
Cdd:PHA03247 2539 GLE-ELASDDAGDPPPPLPPAAPPAAPDrsvpPPRPAPRPSEPAVTSRAR---RPDAPPQ--------SARPRAPVDDRG 2606

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119572635  505 ERARPPPPSTLLRPHNPPGPVPMAPRPRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRTHTGEKP 571
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA 2673
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 220-242 7.02e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.02e-03
                          10        20
                  ....*....|....*....|...
gi 119572635  220 YKCGICGKGFGDSSARIKHQRTH 242
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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