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Conserved domains on  [gi|119581002|gb|EAW60598|]
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chromosome 17 open reading frame 37, isoform CRA_a [Homo sapiens]

Protein Classification

SelT/SelW/SelH family protein( domain architecture ID 10020357)

SelT/SelW/SelH family protein is a selenoprotein that possesses a thioredoxin-like fold and a conserved CXXC or CxxU (U is selenocysteine) motif near the N terminus, suggesting a redox function

CATH:  3.40.30.10
Gene Ontology:  GO:0016020
PubMed:  17503775|1400197|22479358
SCOP:  4002953

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CXXU_selWTH TIGR02174
selT/selW/selH selenoprotein domain; This model represents a domain found in both bacteria and ...
 116-186 3.02e-31

selT/selW/selH selenoprotein domain; This model represents a domain found in both bacteria and animals, including animal proteins SelT, SelW, and SelH, all of which are selenoproteins. In a CXXC motif near the N-terminus of the domain, selenocysteine may replace the second Cys. Proteins with this domain may include an insert of about 70 amino acids. This model is broader than the current SelW model pfam05169 in Pfam.


:

Pssm-ID: 274013  Cd Length: 73  Bit Score: 108.91  E-value: 3.02e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119581002  116 IVVEYCEPCGFEATYLELASAVKEQYPGIEIE--SRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRR 186
Cdd:TIGR02174   1 VEVEYCGSCGYKPRAAELKQALLEEFPDLEIEgeNTPPTTGAFEVEVNGQLVWSKLEGGGFPEPEELKQLIRD 73
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 12-110 2.54e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.38  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581002   12 GKPGTPGDRAREGGSgPDPAPARGASSGAALRGQNVAVAETRRGRPNATLGPSPLQRPRPVTcPRFASHPEAGARAEPAA 91
Cdd:PHA03247 2752 GGPARPARPPTTAGP-PAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL-APAAALPPAASPAGPLP 2829

                          90
                  ....*....|....*....
gi 119581002   92 MSGEPGQTSVAPPPEEVEP 110
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPP 2848
 
Name Accession Description Interval E-value
CXXU_selWTH TIGR02174
selT/selW/selH selenoprotein domain; This model represents a domain found in both bacteria and ...
 116-186 3.02e-31

selT/selW/selH selenoprotein domain; This model represents a domain found in both bacteria and animals, including animal proteins SelT, SelW, and SelH, all of which are selenoproteins. In a CXXC motif near the N-terminus of the domain, selenocysteine may replace the second Cys. Proteins with this domain may include an insert of about 70 amino acids. This model is broader than the current SelW model pfam05169 in Pfam.


Pssm-ID: 274013  Cd Length: 73  Bit Score: 108.91  E-value: 3.02e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119581002  116 IVVEYCEPCGFEATYLELASAVKEQYPGIEIE--SRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRR 186
Cdd:TIGR02174   1 VEVEYCGSCGYKPRAAELKQALLEEFPDLEIEgeNTPPTTGAFEVEVNGQLVWSKLEGGGFPEPEELKQLIRD 73
Rdx pfam10262
Rdx family; This entry is an approximately 100 residue region of selenoprotein-T, conserved ...
 115-186 1.98e-23

Rdx family; This entry is an approximately 100 residue region of selenoprotein-T, conserved from plants to humans. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding. Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. However, despite its binding to UGTR and that its mRNA is up-regulated in extended asphyxia, the function of the protein and hence of this region of it is unknown. Selenoprotein W contains selenium as selenocysteine in the primary protein structure and levels of this selenoprotein are affected by selenium.


Pssm-ID: 463032  Cd Length: 74  Bit Score: 88.74  E-value: 1.98e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119581002  115 RIVVEYCEPCGFEATYLELASAVKEQYPG--IEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRR 186
Cdd:pfam10262   1 RVTIEYCTQCGWLLRAAWLAQELLSTFPDelGEVALIPGTGGAFEVTLDGELVWSRKEDGGFPEPKELKQLVRD 74
COG3526 COG3526
Predicted selenoprotein, Rdx family [General function prediction only];
115-185 2.33e-10

Predicted selenoprotein, Rdx family [General function prediction only];


Pssm-ID: 442748  Cd Length: 93  Bit Score: 55.21  E-value: 2.33e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119581002 115 RIVVEYCEPCGF--EATYL--ELASAVKEQYPGIEIESrlGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIR 185
Cdd:COG3526    5 RVEIEYCTQCGWllRAAWMaqELLTTFGEELGEVALVP--GTGGVFEVRVDGELIWDRKEDGGFPEAKELKQRVR 77
PHA03247 PHA03247
large tegument protein UL36; Provisional
 12-110 2.54e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.38  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581002   12 GKPGTPGDRAREGGSgPDPAPARGASSGAALRGQNVAVAETRRGRPNATLGPSPLQRPRPVTcPRFASHPEAGARAEPAA 91
Cdd:PHA03247 2752 GGPARPARPPTTAGP-PAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL-APAAALPPAASPAGPLP 2829

                          90
                  ....*....|....*....
gi 119581002   92 MSGEPGQTSVAPPPEEVEP 110
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPP 2848
 
Name Accession Description Interval E-value
CXXU_selWTH TIGR02174
selT/selW/selH selenoprotein domain; This model represents a domain found in both bacteria and ...
 116-186 3.02e-31

selT/selW/selH selenoprotein domain; This model represents a domain found in both bacteria and animals, including animal proteins SelT, SelW, and SelH, all of which are selenoproteins. In a CXXC motif near the N-terminus of the domain, selenocysteine may replace the second Cys. Proteins with this domain may include an insert of about 70 amino acids. This model is broader than the current SelW model pfam05169 in Pfam.


Pssm-ID: 274013  Cd Length: 73  Bit Score: 108.91  E-value: 3.02e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119581002  116 IVVEYCEPCGFEATYLELASAVKEQYPGIEIE--SRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRR 186
Cdd:TIGR02174   1 VEVEYCGSCGYKPRAAELKQALLEEFPDLEIEgeNTPPTTGAFEVEVNGQLVWSKLEGGGFPEPEELKQLIRD 73
Rdx pfam10262
Rdx family; This entry is an approximately 100 residue region of selenoprotein-T, conserved ...
 115-186 1.98e-23

Rdx family; This entry is an approximately 100 residue region of selenoprotein-T, conserved from plants to humans. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding. Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. However, despite its binding to UGTR and that its mRNA is up-regulated in extended asphyxia, the function of the protein and hence of this region of it is unknown. Selenoprotein W contains selenium as selenocysteine in the primary protein structure and levels of this selenoprotein are affected by selenium.


Pssm-ID: 463032  Cd Length: 74  Bit Score: 88.74  E-value: 1.98e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119581002  115 RIVVEYCEPCGFEATYLELASAVKEQYPG--IEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRR 186
Cdd:pfam10262   1 RVTIEYCTQCGWLLRAAWLAQELLSTFPDelGEVALIPGTGGAFEVTLDGELVWSRKEDGGFPEPKELKQLVRD 74
COG3526 COG3526
Predicted selenoprotein, Rdx family [General function prediction only];
115-185 2.33e-10

Predicted selenoprotein, Rdx family [General function prediction only];


Pssm-ID: 442748  Cd Length: 93  Bit Score: 55.21  E-value: 2.33e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119581002 115 RIVVEYCEPCGF--EATYL--ELASAVKEQYPGIEIESrlGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIR 185
Cdd:COG3526    5 RVEIEYCTQCGWllRAAWMaqELLTTFGEELGEVALVP--GTGGVFEVRVDGELIWDRKEDGGFPEAKELKQRVR 77
PHA03247 PHA03247
large tegument protein UL36; Provisional
 12-110 2.54e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.38  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581002   12 GKPGTPGDRAREGGSgPDPAPARGASSGAALRGQNVAVAETRRGRPNATLGPSPLQRPRPVTcPRFASHPEAGARAEPAA 91
Cdd:PHA03247 2752 GGPARPARPPTTAGP-PAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL-APAAALPPAASPAGPLP 2829

                          90
                  ....*....|....*....
gi 119581002   92 MSGEPGQTSVAPPPEEVEP 110
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPP 2848
PHA03247 PHA03247
large tegument protein UL36; Provisional
 14-110 3.69e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.00  E-value: 3.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581002   14 PGTPGDRAREGGSGPDPAPARGASSGAALRGQNVAVAETRRGRPNATLGPSPLQRPR-PVTCPRFASHPEAGARAEPAAM 92
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAaPAAGPPRRLTRPAVASLSESRE 2796

                          90
                  ....*....|....*...
gi 119581002   93 SGePGQTSVAPPPEEVEP 110
Cdd:PHA03247 2797 SL-PSPWDPADPPAAVLA 2813
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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