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Conserved domains on  [gi|119586555|gb|EAW66151|]
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myosin, heavy polypeptide 7, cardiac muscle, beta, isoform CRA_a [Homo sapiens]

Protein Classification

kinesin family protein; kinesin/myosin motor domain-containing protein( domain architecture ID 13414256)

kinesin family protein is a microtubule-dependent molecular motor that plays an important role in intracellular transport and in cell division and has ATPase-containing motor domain; similar to carboxy-terminal kinesins that contains a C-terminal domain responsible for the motor activity (it hydrolyzes ATP and binds microtubules); kinesin/myosin motor domain-containing protein may have ATPase activity and function as a molecular motor, such as kinesins and myosins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MYSc_Myh7 cd14917
class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I ...
 99-766 0e+00

class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I cardiac muscle myosin heavy chain 7 (also called CMH1, MPD1, and CMD1S). Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. It is expressed predominantly in normal human ventrical and in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


:

Pssm-ID: 276881 [Multi-domain]  Cd Length: 668  Bit Score: 1388.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14917     1 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14917    81 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14917   161 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14917   241 LGFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14917   321 QVIYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14917   401 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSNNFQKPRNIKGKPEAHFS 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14917   481 LIHYAGTVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14917   561 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 640

                         650       660
                  ....*....|....*....|....*...
gi 119586555  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14917   641 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 668
COG5022 super family cl34868
Myosin heavy chain [General function prediction only];
37-1433 0e+00

Myosin heavy chain [General function prediction only];


The actual alignment was detected with superfamily member COG5022:

Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 858.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   37 VFVPDDKQEFVKAKIVSRE--GGKVTAE--TEYGKTVTVKEDQVMQ--QNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYG 110
Cdd:COG5022    12 CWIPDEEKGWIWAEIIKEAfnKGKVTEEgkKEDGESVSVKKKVLGNdrIKLPKFDGVDDLTELSYLNEPAVLHNLEKRYN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  111 SWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKR 190
Cdd:COG5022    92 NGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGKTENAKR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  191 VIQYFAVIAAIgdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEK 270
Cdd:COG5022   172 IMQYLASVTSS-------STVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKIETYLLEK 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  271 SRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGE-TTVASIDDAEELMATDNAFDVLGFTSEEKNSM 349
Cdd:COG5022   245 SRVVHQNKNERNYHIFYQLLAGDPEELKKLLLLQN-PKDYIYLSQGGcDKIDGIDDAKEFKITLDALKTIGIDEEEQDQI 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  350 YKLTGAIMHFGNMKFKlKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAK 429
Cdd:COG5022   324 FKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALAIRDSLAK 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  430 AVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWT 509
Cdd:COG5022   403 ALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYVKEGIEWS 482

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  510 FIDFgMDLQACIDLIEK--PMGIMSILEEECMFPKATDMTFKAKLFDN-HLGKSANFQKPRNIKGKpeahFSLIHYAGIV 586
Cdd:COG5022   483 FIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK----FVVKHYAGDV 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  587 DYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADapiekgkgkakKGSSFQTVSALHRENLNKLMTNLRSTH 666
Cdd:COG5022   558 EYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEENIE-----------SKGRFPTLGSRFKESLNSLMSTLNSTQ 626

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  667 PHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI---DSRKGAE 743
Cdd:COG5022   627 PHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTwkeDTKNAVK 706

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  744 KLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMG 823
Cdd:COG5022   707 SILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRLRRL 786

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  824 VKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEK----SEARRKELEEKMVSLLQE---------------K 884
Cdd:COG5022   787 VDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQKTIKRekklRETEEVEFSLKAEVLIQKfgrslkakkrfsllkK 866

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  885 NDLQLQVQAEQDNL--------ADAEER----------------------CDQLIKNKIQLE--AKVKEMNE--RLEDEE 930
Cdd:COG5022   867 ETIYLQSAQRVELAerqlqelkIDVKSIsslklvnleleseiielkkslsSDLIENLEFKTEliARLKKLLNniDLEEGP 946

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  931 EMNAELTAKKRKLEDECSELKRDIDDLELTLakveKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ----- 1005
Cdd:COG5022   947 SIEYVKLPELNKLHEVESKLKETSEEYEDLL----KKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQlkelp 1022

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1006 -ALDDLQAEEDKVNTLTKAKvKLEQQVDDLEGSLEQEKK------VRMDLERAKRKLEGDLKLTQESIMDLEN-----DK 1073
Cdd:COG5022  1023 vEVAELQSASKIISSESTEL-SILKPLQKLKGLLLLENNqlqaryKALKLRRENSLLDDKQLYQLESTENLLKtinvkDL 1101

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1074 QQLDERLKKKDFELNAL------NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS 1147
Cdd:COG5022  1102 EVTNRNLVKPANVLQFIvaqmikLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKR 1181

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1148 ER----LEEAGGATSVQIEMnKKREAEFqKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Cdd:COG5022  1182 LYqsalYDEKSKLSSSEVND-LKNELIA-LFSKIFSGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKKFDTPASMSNE 1259

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1224 fklELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEHrskaeetqrSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1303
Cdd:COG5022  1260 ---KLLSLLNSIDNLLSSYKLEEEVLPATINSLLQYI---------NVGLFNALRTKASSLRWKSATEVNYNSEELDDWC 1327

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1304 RgkltyTQQLEDLKRQLE---EEVKAKNALAHALQSARHDCDLLREQYEEETEA-KAELQRVLSKANSEvAQWRTKYETD 1379
Cdd:COG5022  1328 R-----EFEISDVDEELEeliQAVKVLQLLKDDLNKLDELLDACYSLNPAEIQNlKSRYDPADKENNLP-KEILKKIEAL 1401

                        1450      1460      1470      1480      1490
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555 1380 AIQRTEELE-EAKKKLAQRLQE-AEEAVEAVNAKCSSLEKTKhRLQNEIEDLMVDV 1433
Cdd:COG5022  1402 LIKQELQLSlEGKDETEVHLSEiFSEEKSLISLDRNSIYKEE-VLSSLSALLTKEK 1456
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1173-1931 4.83e-32

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 137.11  E-value: 4.83e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1173 KMRRdlEEATLQHEATAAALrKKHADSVAELGEQIDNLQRVKQK----LEKEKSEFKLELDDVTSNMEQiIKAKAANLEK 1248
Cdd:TIGR02168  171 KERR--KETERKLERTRENL-DRLEDILNELERQLKSLERQAEKaeryKELKAELRELELALLVLRLEE-LREELEELQE 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1249 MCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEevkAKN 1328
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEE---LEA 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1329 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRtkyetDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1408
Cdd:TIGR02168  324 QLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELE-----ELESRLEELEEQLETLRSKVAQLELQIASL 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1409 NAKCSSLEKTKHRLQNEIEDLMVDVE--RSNAAAAALDKKQRNF---DKILAEWKQKYEESQSELESSQKEARSLSTELF 1483
Cdd:TIGR02168  399 NNEIERLEARLERLEDRRERLQQEIEelLKKLEEAELKELQAELeelEEELEELQEELERLEEALEELREELEEAEQALD 478

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1484 KLKN----------AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA---EKME------LQSA 1544
Cdd:TIGR02168  479 AAERelaqlqarldSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAalgGRLQavvvenLNAA 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1545 LEEAEASLEHEEGK--------ILRAQLEFN--QIKAEIERKLAEKDEEMEQAKR---------NHLRVVDSLQTSLDAE 1605
Cdd:TIGR02168  559 KKAIAFLKQNELGRvtflpldsIKGTEIQGNdrEILKNIEGFLGVAKDLVKFDPKlrkalsyllGGVLVVDDLDNALELA 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1606 TRSRNEALRVKKkmEGDL-----------NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1674
Cdd:TIGR02168  639 KKLRPGYRIVTL--DGDLvrpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQ 716

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1675 V-------ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ 1747
Cdd:TIGR02168  717 LrkeleelSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKE 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1748 ECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKgGKKQLQKLEARVRELENEL 1827
Cdd:TIGR02168  797 ELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIES-LAAEIEELEELIEELESEL 875

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1828 EAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR-KVQHELDE 1906
Cdd:TIGR02168  876 EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSeEYSLTLEE 955

                          810       820
                   ....*....|....*....|....*
gi 119586555  1907 AEERADIAESQVNKLRAKSRDIGTK 1931
Cdd:TIGR02168  956 AEALENKIEDDEEEARRRLKRLENK 980
 
Name Accession Description Interval E-value
MYSc_Myh7 cd14917
class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I ...
 99-766 0e+00

class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I cardiac muscle myosin heavy chain 7 (also called CMH1, MPD1, and CMD1S). Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. It is expressed predominantly in normal human ventrical and in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276881 [Multi-domain]  Cd Length: 668  Bit Score: 1388.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14917     1 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14917    81 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14917   161 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14917   241 LGFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14917   321 QVIYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14917   401 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSNNFQKPRNIKGKPEAHFS 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14917   481 LIHYAGTVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14917   561 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 640

                         650       660
                  ....*....|....*....|....*...
gi 119586555  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14917   641 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 668
Myosin_head pfam00063
Myosin head (motor domain);
87-766 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 1083.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    87 IEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYML 166
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   167 TDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKkdqspgKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGK 246
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSGSGSAGN------VGRLEEQILQSNPILEAFGNAKTVRNNNSSRFGK 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   247 FIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITnNPYDYAFISQ-GETTVASIDD 325
Cdd:pfam00063  155 YIEIQFDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGASAQLKKELRLT-NPKDYHYLSQsGCYTIDGIDD 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   326 AEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVK 405
Cdd:pfam00063  234 SEEFKITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRRIK 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   406 VGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQ-PRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEK 484
Cdd:pfam00063  314 TGRETVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDVKTiEKASFIGVLDIYGFEIFEKNSFEQLCINYVNEK 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   485 LQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANF 563
Cdd:pfam00063  394 LQQFFNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYSTF-SKHPHF 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   564 QKPRNIKgkpEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAK---- 639
Cdd:pfam00063  472 QKPRLQG---ETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFPDYETAESAAANESGKSTpkrt 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   640 KGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFR 719
Cdd:pfam00063  549 KKKRFITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQEFV 628

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 119586555   720 QRYRILNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:pfam00063  629 QRYRILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
 80-778 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 1029.80  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555     80 NPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISD 159
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    160 NAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAigdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRND 239
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVSG--------SNTEVGSVEDQILESNPILEAFGNAKTLRNN 152

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    240 NSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGET- 318
Cdd:smart00242  153 NSSRFGKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGASEELKKELGLKS-PEDYRYLNQGGCl 231

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    319 TVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQA-EPDGTEEADKSAYLMGLNSADLLK 397
Cdd:smart00242  232 TVDGIDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAAsTVKDKEELSNAAELLGVDPEELEK 311

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    398 GLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLC 477
Cdd:smart00242  312 ALTKRKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQLC 391

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    478 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLfDNH 556
Cdd:smart00242  392 INYANEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKL-NQH 469

                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    557 LGKSANFQKPRNikgKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGadapiekgkg 636
Cdd:smart00242  470 HKKHPHFSKPKK---KGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLFPSGVS---------- 536

                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    637 KAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 716
Cdd:smart00242  537 NAGSKKRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLPFD 616

                           650       660       670       680       690       700
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119586555    717 DFRQRYRILNPAAIPEGQFiDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRD 778
Cdd:smart00242  617 EFLQRYRVLLPDTWPPWGG-DAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
COG5022 COG5022
Myosin heavy chain [General function prediction only];
37-1433 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 858.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   37 VFVPDDKQEFVKAKIVSRE--GGKVTAE--TEYGKTVTVKEDQVMQ--QNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYG 110
Cdd:COG5022    12 CWIPDEEKGWIWAEIIKEAfnKGKVTEEgkKEDGESVSVKKKVLGNdrIKLPKFDGVDDLTELSYLNEPAVLHNLEKRYN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  111 SWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKR 190
Cdd:COG5022    92 NGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGKTENAKR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  191 VIQYFAVIAAIgdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEK 270
Cdd:COG5022   172 IMQYLASVTSS-------STVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKIETYLLEK 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  271 SRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGE-TTVASIDDAEELMATDNAFDVLGFTSEEKNSM 349
Cdd:COG5022   245 SRVVHQNKNERNYHIFYQLLAGDPEELKKLLLLQN-PKDYIYLSQGGcDKIDGIDDAKEFKITLDALKTIGIDEEEQDQI 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  350 YKLTGAIMHFGNMKFKlKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAK 429
Cdd:COG5022   324 FKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALAIRDSLAK 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  430 AVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWT 509
Cdd:COG5022   403 ALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYVKEGIEWS 482

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  510 FIDFgMDLQACIDLIEK--PMGIMSILEEECMFPKATDMTFKAKLFDN-HLGKSANFQKPRNIKGKpeahFSLIHYAGIV 586
Cdd:COG5022   483 FIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK----FVVKHYAGDV 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  587 DYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADapiekgkgkakKGSSFQTVSALHRENLNKLMTNLRSTH 666
Cdd:COG5022   558 EYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEENIE-----------SKGRFPTLGSRFKESLNSLMSTLNSTQ 626

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  667 PHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI---DSRKGAE 743
Cdd:COG5022   627 PHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTwkeDTKNAVK 706

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  744 KLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMG 823
Cdd:COG5022   707 SILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRLRRL 786

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  824 VKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEK----SEARRKELEEKMVSLLQE---------------K 884
Cdd:COG5022   787 VDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQKTIKRekklRETEEVEFSLKAEVLIQKfgrslkakkrfsllkK 866

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  885 NDLQLQVQAEQDNL--------ADAEER----------------------CDQLIKNKIQLE--AKVKEMNE--RLEDEE 930
Cdd:COG5022   867 ETIYLQSAQRVELAerqlqelkIDVKSIsslklvnleleseiielkkslsSDLIENLEFKTEliARLKKLLNniDLEEGP 946

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  931 EMNAELTAKKRKLEDECSELKRDIDDLELTLakveKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ----- 1005
Cdd:COG5022   947 SIEYVKLPELNKLHEVESKLKETSEEYEDLL----KKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQlkelp 1022

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1006 -ALDDLQAEEDKVNTLTKAKvKLEQQVDDLEGSLEQEKK------VRMDLERAKRKLEGDLKLTQESIMDLEN-----DK 1073
Cdd:COG5022  1023 vEVAELQSASKIISSESTEL-SILKPLQKLKGLLLLENNqlqaryKALKLRRENSLLDDKQLYQLESTENLLKtinvkDL 1101

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1074 QQLDERLKKKDFELNAL------NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS 1147
Cdd:COG5022  1102 EVTNRNLVKPANVLQFIvaqmikLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKR 1181

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1148 ER----LEEAGGATSVQIEMnKKREAEFqKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Cdd:COG5022  1182 LYqsalYDEKSKLSSSEVND-LKNELIA-LFSKIFSGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKKFDTPASMSNE 1259

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1224 fklELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEHrskaeetqrSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1303
Cdd:COG5022  1260 ---KLLSLLNSIDNLLSSYKLEEEVLPATINSLLQYI---------NVGLFNALRTKASSLRWKSATEVNYNSEELDDWC 1327

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1304 RgkltyTQQLEDLKRQLE---EEVKAKNALAHALQSARHDCDLLREQYEEETEA-KAELQRVLSKANSEvAQWRTKYETD 1379
Cdd:COG5022  1328 R-----EFEISDVDEELEeliQAVKVLQLLKDDLNKLDELLDACYSLNPAEIQNlKSRYDPADKENNLP-KEILKKIEAL 1401

                        1450      1460      1470      1480      1490
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555 1380 AIQRTEELE-EAKKKLAQRLQE-AEEAVEAVNAKCSSLEKTKhRLQNEIEDLMVDV 1433
Cdd:COG5022  1402 LIKQELQLSlEGKDETEVHLSEiFSEEKSLISLDRNSIYKEE-VLSSLSALLTKEK 1456
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 845-1924 3.73e-172

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 554.40  E-value: 3.73e-172
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNE 924
Cdd:pfam01576    3 QEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELES 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   925 RLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Cdd:pfam01576   83 RLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERIS 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1005 QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKD 1084
Cdd:pfam01576  163 EFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKE 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1085 FELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164
Cdd:pfam01576  243 EELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELR 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKaA 1244
Cdd:pfam01576  323 SKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAK-Q 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1245 NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEV 1324
Cdd:pfam01576  402 DSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEET 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1325 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQEAEEA 1404
Cdd:pfam01576  482 RQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQ 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1405 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFK 1484
Cdd:pfam01576  561 LEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALS 640

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1485 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1564
Cdd:pfam01576  641 LARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEV 720

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1565 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV 1644
Cdd:pfam01576  721 NMQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQL 800

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1645 KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1724
Cdd:pfam01576  801 KKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSAL 880

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1725 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1804
Cdd:pfam01576  881 QDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGT 960

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1805 ALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAE 1884
Cdd:pfam01576  961 VKSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLE 1040

                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|
gi 119586555  1885 EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1924
Cdd:pfam01576 1041 EAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
PTZ00014 PTZ00014
myosin-A; Provisional
 62-819 1.02e-128

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 425.21  E-value: 1.02e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   62 ETEYGKTVTVKEDQVMQQNPP-KFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVA 140
Cdd:PTZ00014   72 DPPTNSTFEVKPEHAFNANSQiDPMTYGDIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNTTNDWIR 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  141 AYR-GKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAViAAIGDRSKKDQspgkgtleDQ 219
Cdd:PTZ00014  152 RYRdAKDSDKLPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFAS-SKSGNMDLKIQ--------NA 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  220 IIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLD 299
Cdd:PTZ00014  223 IMAANPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYHIFYQLLKGANDEMKE 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  300 MLLITNNPyDYAFISQGETTVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFklKQREEQAEPDGTE 379
Cdd:PTZ00014  303 KYKLKSLE-EYKYINPKCLDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGNVEI--EGKEEGGLTDAAA 379

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  380 EADKS-------AYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQP 452
Cdd:PTZ00014  380 ISDESlevfneaCELLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLFLWIIRNLNATIEPPGG 459

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  453 RQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGI-----EWTfidfgmDLQACIDLI-EK 526
Cdd:PTZ00014  460 FKVFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGIsteelEYT------SNESVIDLLcGK 533

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  527 PMGIMSILEEECMFPKATDMTFKAKLFdNHLGKSANFQKPRNIKGKpeaHFSLIHYAGIVDYNIIGWLQKNKDPLNETVV 606
Cdd:PTZ00014  534 GKSVLSILEDQCLAPGGTDEKFVSSCN-TNLKNNPKYKPAKVDSNK---NFVIKHTIGDIQYCASGFLFKNKDVLRPELV 609

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  607 GLYQKSSLKLLSTLFanyagADAPIEKGKGKAKKGSSFQTVsalhrENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDN 686
Cdd:PTZ00014  610 EVVKASPNPLVRDLF-----EGVEVEKGKLAKGQLIGSQFL-----NQLDSLMSLINSTEPHFIRCIKPNENKKPLDWNS 679

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  687 PLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNpAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:PTZ00014  680 SKVLIQLHSLSILEALQLRQLGFSYRRTFAEFLSQFKYLD-LAVSNDSSLDPKEKAEKLLERSGLPKDSYAIGKTMVFLK 758

                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555  767 AGLLGLLEEMRDERLSR---IITRIQAQSRGVLARmeyKKLLERRDSLLVIQWNIR 819
Cdd:PTZ00014  759 KDAAKELTQIQREKLAAwepLVSVLEALILKIKKK---RKVRKNIKSLVRIQAHLR 811
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1173-1931 4.83e-32

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 137.11  E-value: 4.83e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1173 KMRRdlEEATLQHEATAAALrKKHADSVAELGEQIDNLQRVKQK----LEKEKSEFKLELDDVTSNMEQiIKAKAANLEK 1248
Cdd:TIGR02168  171 KERR--KETERKLERTRENL-DRLEDILNELERQLKSLERQAEKaeryKELKAELRELELALLVLRLEE-LREELEELQE 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1249 MCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEevkAKN 1328
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEE---LEA 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1329 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRtkyetDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1408
Cdd:TIGR02168  324 QLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELE-----ELESRLEELEEQLETLRSKVAQLELQIASL 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1409 NAKCSSLEKTKHRLQNEIEDLMVDVE--RSNAAAAALDKKQRNF---DKILAEWKQKYEESQSELESSQKEARSLSTELF 1483
Cdd:TIGR02168  399 NNEIERLEARLERLEDRRERLQQEIEelLKKLEEAELKELQAELeelEEELEELQEELERLEEALEELREELEEAEQALD 478

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1484 KLKN----------AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA---EKME------LQSA 1544
Cdd:TIGR02168  479 AAERelaqlqarldSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAalgGRLQavvvenLNAA 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1545 LEEAEASLEHEEGK--------ILRAQLEFN--QIKAEIERKLAEKDEEMEQAKR---------NHLRVVDSLQTSLDAE 1605
Cdd:TIGR02168  559 KKAIAFLKQNELGRvtflpldsIKGTEIQGNdrEILKNIEGFLGVAKDLVKFDPKlrkalsyllGGVLVVDDLDNALELA 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1606 TRSRNEALRVKKkmEGDL-----------NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1674
Cdd:TIGR02168  639 KKLRPGYRIVTL--DGDLvrpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQ 716

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1675 V-------ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ 1747
Cdd:TIGR02168  717 LrkeleelSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKE 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1748 ECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKgGKKQLQKLEARVRELENEL 1827
Cdd:TIGR02168  797 ELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIES-LAAEIEELEELIEELESEL 875

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1828 EAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR-KVQHELDE 1906
Cdd:TIGR02168  876 EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSeEYSLTLEE 955

                          810       820
                   ....*....|....*....|....*
gi 119586555  1907 AEERADIAESQVNKLRAKSRDIGTK 1931
Cdd:TIGR02168  956 AEALENKIEDDEEEARRRLKRLENK 980
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 840-1673 3.99e-30

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 130.95  E-value: 3.99e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKV 919
Cdd:TIGR02168  218 LKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEI 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   920 KEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 999
Cdd:TIGR02168  298 SRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEEL 377

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1000 QEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLEraKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Cdd:TIGR02168  378 EEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELL--KKLEEAELKELQAELEELEEELEELQEE 455

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT---ARAKVEKLRSDLSRELEEISER------- 1149
Cdd:TIGR02168  456 LERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfseGVKALLKNQSGLSGILGVLSELisvdegy 535

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1150 ---LEEAGGATSVQIEMNKKREAefqkmrRDLEEATLQHEATAAAL----RKKHADSVAELGEQIDNLQRVKQ---KLEK 1219
Cdd:TIGR02168  536 eaaIEAALGGRLQAVVVENLNAA------KKAIAFLKQNELGRVTFlpldSIKGTEIQGNDREILKNIEGFLGvakDLVK 609

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1220 EKSEFKLELDD------VTSNMEQII-KAKAANLEKMCRTLEDQM-----------NEHRSKAEETQRSVNDLTSQRAKL 1281
Cdd:TIGR02168  610 FDPKLRKALSYllggvlVVDDLDNALeLAKKLRPGYRIVTLDGDLvrpggvitggsAKTNSSILERRREIEELEEKIEEL 689

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1282 QTENGELSRQLDEKEALISQLtrgkltyTQQLEDLKRQLEEEVKAKNALAHALQSArhdcdllreqyEEETEAKAELQRV 1361
Cdd:TIGR02168  690 EEKIAELEKALAELRKELEEL-------EEELEQLRKELEELSRQISALRKDLARL-----------EAEVEQLEERIAQ 751

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1362 LSKANSEVAQWRTKYEtdaiQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLmvdversNAAAA 1441
Cdd:TIGR02168  752 LSKELTELEAEIEELE----ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL-------NEEAA 820

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1442 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSG 1521
Cdd:TIGR02168  821 NLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELS 900

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1522 KTIHELEKVRKQLEAEKMELQSALEEAEASLEheegkilRAQLEFNQIKAeierKLAEKDE-EMEQAKRNHLRVVDSLQt 1600
Cdd:TIGR02168  901 EELRELESKRSELRRELEELREKLAQLELRLE-------GLEVRIDNLQE----RLSEEYSlTLEEAEALENKIEDDEE- 968

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119586555  1601 sldaETRSRNEALRVKKKMEGDLNEMEIQlshanrmaaEAQKQVKSLQSLLKdtqiQLDDAVRANDDLKENIA 1673
Cdd:TIGR02168  969 ----EARRRLKRLENKIKELGPVNLAAIE---------EYEELKERYDFLTA----QKEDLTEAKETLEEAIE 1024
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1311-1929 3.73e-24

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 111.18  E-value: 3.73e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1311 QQLEDLKRQ-----------LEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVaqwrtkyetd 1379
Cdd:COG1196   200 RQLEPLERQaekaeryrelkEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAEL---------- 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1380 aiqrtEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1459
Cdd:COG1196   270 -----EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEE 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1460 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM 1539
Cdd:COG1196   345 ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELE 424

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1540 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRsrneaLRVKKKM 1619
Cdd:COG1196   425 ELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAAR-----LLLLLEA 499

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1620 EGDlnemeiqlshanrmAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQaeleelRAVVEQTERS 1699
Cdd:COG1196   500 EAD--------------YEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQ------NIVVEDDEVA 559

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1700 RKLAEQELIETSERVQLLHSqntSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1779
Cdd:COG1196   560 AAAIEYLKAAKAGRATFLPL---DKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAAL 636

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1780 LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVkgmRKSERRIKELTYQTEEDR 1859
Cdd:COG1196   637 RRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELEL---EEALLAEEEEERELAEAE 713

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1860 KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSkfrKVQHELDEAEERADIAESQVNKLRAKSRDIG 1929
Cdd:COG1196   714 EERLEEELEEEALEEQLEAEREELLEELLEEEELLE---EEALEELPEPPDLEELERELERLEREIEALG 780
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1128-1908 1.61e-19

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 95.96  E-value: 1.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1128 ARAKVEKLRSDLSRELEEISERLEEAGgatsvqiEMNKKREAEFQK----MRRDLEEATLQHEATAAaLRKKHADSVAEL 1203
Cdd:pfam15921   72 GKEHIERVLEEYSHQVKDLQRRLNESN-------ELHEKQKFYLRQsvidLQTKLQEMQMERDAMAD-IRRRESQSQEDL 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1204 GEQidnLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAAN---LEKMCRTLED-------QMNEHRSKAEETQRSVND 1273
Cdd:pfam15921  144 RNQ---LQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHegvLQEIRSILVDfeeasgkKIYEHDSMSTMHFRSLGS 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1274 LTSQRAK-LQTENGELSRQL----DEKEALISQLTRGKLTYTQQLEDLKRQL--EEEVKAkNALAHALQSARHDCDLLRE 1346
Cdd:pfam15921  221 AISKILReLDTEISYLKGRIfpveDQLEALKSESQNKIELLLQQHQDRIEQLisEHEVEI-TGLTEKASSARSQANSIQS 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1347 QYE----EETEAKAELQRVLSKANSEVAQWRTkyetdaiqrteELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR- 1421
Cdd:pfam15921  300 QLEiiqeQARNQNSMYMRQLSDLESTVSQLRS-----------ELREAKRMYEDKIEELEKQLVLANSELTEARTERDQf 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1422 ------LQNEIEDLMVDV-ERSNAAAAALDKKQRNFDKILAEwKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1494
Cdd:pfam15921  369 sqesgnLDDQLQKLLADLhKREKELSLEKEQNKRLWDRDTGN-SITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQME 447

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1495 -HLETFKRENKNLqEEISDLTEQLGSsgkTIHELEKVRKQLEAEKMELQSA---LEEAEASLEHEEGKILRAQLEFNQIK 1570
Cdd:pfam15921  448 rQMAAIQGKNESL-EKVSSLTAQLES---TKEMLRKVVEELTAKKMTLESSertVSDLTASLQEKERAIEATNAEITKLR 523

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1571 AEIERKLaekdEEMEQAKR--NHLRVVdslQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1648
Cdd:pfam15921  524 SRVDLKL----QELQHLKNegDHLRNV---QTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLE 596

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1649 SLLKDTQIQLDDAVRANDdlKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQElietSERVQLLHSQNTSLiNQK 1728
Cdd:pfam15921  597 KEINDRRLELQEFKILKD--KKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIK----QERDQLLNEVKTSR-NEL 669

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1729 KKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE----LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE-- 1802
Cdd:pfam15921  670 NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQtrntLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQsk 749

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1803 ----QIALKGGKKQLQKLEARVRELENELEA---EQKRNAESVKGMRKSERRIKEltyqteedrkNLLRLQDLVDKLQLK 1875
Cdd:pfam15921  750 iqflEEAMTNANKEKHFLKEEKNKLSQELSTvatEKNKMAGELEVLRSQERRLKE----------KVANMEVALDKASLQ 819

                          810       820       830
                   ....*....|....*....|....*....|...
gi 119586555  1876 VkAYKRQAEEAEEQANTNLskfrKVQHELDEAE 1908
Cdd:pfam15921  820 F-AECQDIIQRQEQESVRL----KLQHTLDVKE 847
PTZ00121 PTZ00121
MAEBL; Provisional
 845-1619 4.48e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 94.82  E-value: 4.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQleaKVKEMNE 924
Cdd:PTZ00121 1158 RKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAE---AVKKAEE 1234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  925 RLEDEEEmnAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNlTEEMAGLDEiiAKLTKEKKALQEAHQ 1004
Cdd:PTZ00121 1235 AKKDAEE--AKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKK-AEEKKKADE--AKKAEEKKKADEAKK 1309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1005 QALDDLQAEEDKVNT------LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDE 1078
Cdd:PTZ00121 1310 KAEEAKKADEAKKKAeeakkkADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEE 1389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1079 RLKKKDFELNALNARIE-DEQALGSQLQKKLKELQARIEELEEELEAERTA----RAKVEKLRSDLSRELEEISERLEEA 1153
Cdd:PTZ00121 1390 KKKADEAKKKAEEDKKKaDELKKAAAAKKKADEAKKKAEEKKKADEAKKKAeeakKADEAKKKAEEAKKAEEAKKKAEEA 1469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1154 GGATSVQIEMNKKREAEfqKMRRDLEEATLQ-HEATAAALRKKHADSV--AELGEQIDNLQRVKQKL---EKEKSEFKLE 1227
Cdd:PTZ00121 1470 KKADEAKKKAEEAKKAD--EAKKKAEEAKKKaDEAKKAAEAKKKADEAkkAEEAKKADEAKKAEEAKkadEAKKAEEKKK 1547

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1228 LDDVtSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ---LDEKEALISQLTR 1304
Cdd:PTZ00121 1548 ADEL-KKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEeakKAEEAKIKAEELK 1626

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1305 GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYETDAIQR 1383
Cdd:PTZ00121 1627 KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEdEKKAAEALKKEAEEAKKAEE 1706

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1384 TEELEEAKKKLAQRLQEAEEAVEavnAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNfdkilAEWKQKYEE 1463
Cdd:PTZ00121 1707 LKKKEAEEKKKAEELKKAEEENK---IKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKK-----AEEIRKEKE 1778

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1464 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE----NKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM 1539
Cdd:PTZ00121 1779 AVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGnlviNDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNN 1858

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1540 EL-QSALEEAEASLEheegKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL-RVVDSLQTSLDAETRSRNEALRVKK 1617
Cdd:PTZ00121 1859 ENgEDGNKEADFNKE----KDLKEDDEEEIEEADEIEKIDKDDIEREIPNNNMAgKNNDIIDDKLDKDEYIKRDAEETRE 1934


                  ..
gi 119586555 1618 KM 1619
Cdd:PTZ00121 1935 EI 1936
PTZ00121 PTZ00121
MAEBL; Provisional
 1156-1912 5.89e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.36  E-value: 5.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1156 ATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAElGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM 1235
Cdd:PTZ00121 1089 ADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARK-AEDARKAEEARKAEDAKRVEIARKAEDARKAE 1167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1236 EQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVndlTSQRAKLQTENGELSRQLDEKealisqltrgKLTYTQQLED 1315
Cdd:PTZ00121 1168 EARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAE---AARKAEEERKAEEARKAEDAK----------KAEAVKKAEE 1234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1316 LKRQlEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRvlsKANsEVAQWRTKYETDAIQRTEE---LEEAKK 1392
Cdd:PTZ00121 1235 AKKD-AEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEAR---KAD-ELKKAEEKKKADEAKKAEEkkkADEAKK 1309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1393 KlaqrlqeAEEAVEAVNAKCSSLEKTKhrlqnEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1472
Cdd:PTZ00121 1310 K-------AEEAKKADEAKKKAEEAKK-----KADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAK 1377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1473 KEARSLSTELFKLKNAyeeslEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKmELQSALEEAEASL 1552
Cdd:PTZ00121 1378 KKADAAKKKAEEKKKA-----DEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKK-KAEEAKKADEAKK 1451

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1553 EHEEGKilraqlefnqiKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAEtRSRNEALRVKKKMEGDLNEMEIQLSH 1632
Cdd:PTZ00121 1452 KAEEAK-----------KAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAE-EAKKKADEAKKAAEAKKKADEAKKAE 1519

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1633 ANRMAAEAQK--QVKSLQSLLKDTQIQLDDAVRANDDLKEniaiVERRNNLLQAELEELRavveqteRSRKLAEQELIET 1710
Cdd:PTZ00121 1520 EAKKADEAKKaeEAKKADEAKKAEEKKKADELKKAEELKK----AEEKKKAEEAKKAEED-------KNMALRKAEEAKK 1588

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1711 SERVQLlhSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1790
Cdd:PTZ00121 1589 AEEARI--EEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEE 1666

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1791 IKDLQHRLDEAEQiALKGGKKQLQKLEARVREleneleAEQKRNAESVKGMRKSERRIKELTYQTEEDRKnllrlqdlvd 1870
Cdd:PTZ00121 1667 AKKAEEDKKKAEE-AKKAEEDEKKAAEALKKE------AEEAKKAEELKKKEAEEKKKAEELKKAEEENK---------- 1729

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*
gi 119586555 1871 klqLKVKAYKRQAEEAE---EQANTNLSKFRKVQHELDEAEERAD 1912
Cdd:PTZ00121 1730 ---IKAEEAKKEAEEDKkkaEEAKKDEEEKKKIAHLKKEEEKKAE 1771
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1262-1589 3.80e-06

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 51.94  E-value: 3.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1262 SKAEETQRSVNDLTsqRAKLQTENGELSRQLDEKE-----ALISQLTRGKLTYTQQLEDLKRQLEEEV--KAKNALAHAL 1334
Cdd:NF033838   50 SSGNESQKEHAKEV--ESHLEKILSEIQKSLDKRKhtqnvALNKKLSDIKTEYLYELNVLKEKSEAELtsKTKKELDAAF 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1335 QSARHDCDLLREQYEEETEAKAELQRvlsKANSEVAQWRTKYETDAIqRTEELEEAKKKLaqRLQEAEEAVEAVNAKCSS 1414
Cdd:NF033838  128 EQFKKDTLEPGKKVAEATKKVEEAEK---KAKDQKEEDRRNYPTNTY-KTLELEIAESDV--EVKKAELELVKEEAKEPR 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1415 LEKTkhrlqneIEDLMVDVERSNAAAAALDKKQRnfDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1494
Cdd:NF033838  202 DEEK-------IKQAKAKVESKKAEATRLEKIKT--DREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGE 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1495 HLETFKRENKNLQEEISDLTEQLGS----SGKTIHELEK-----------------------VRKQLEAEKMELQSALEE 1547
Cdd:NF033838  273 PATPDKKENDAKSSDSSVGEETLPSpslkPEKKVAEAEKkveeakkkakdqkeedrrnyptnTYKTLELEIAESDVKVKE 352

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 119586555 1548 AEASLEHEEGKILRAQLEFNQIKAEIERKLAE----------KDEEMEQAKR 1589
Cdd:NF033838  353 AELELVKEEAKEPRNEEKIKQAKAKVESKKAEatrlekiktdRKKAEEEAKR 404
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 902-1043 2.84e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.93  E-value: 2.84e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    902 EERCDQLIKNKIQLEAKVKEMNErleDEEEMNAELTakkrkledECSELKRDIDDLELTL-AKVEKEKHATENKVKNLTE 980
Cdd:smart00787  136 EWRMKLLEGLKEGLDENLEGLKE---DYKLLMKELE--------LLNSIKPKLRDRKDALeEELRQLKQLEDELEDCDPT 204

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119586555    981 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043
Cdd:smart00787  205 ELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG 267
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 840-1017 3.23e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.31  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  840 LKSAEREKEmaSMKEEFTRLK-----------EALEKSEARRKELEEKMVSLlQEKNDLQ-------LQVQAEQDNLADA 901
Cdd:NF033838  206 IKQAKAKVE--SKKAEATRLEkiktdrekaeeEAKRRADAKLKEAVEKNVAT-SEQDKPKrrakrgvLGEPATPDKKEND 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  902 EERCDQLI-------------KNKIQLEAKVKEMNERLED--EEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK 966
Cdd:NF033838  283 AKSSDSSVgeetlpspslkpeKKVAEAEKKVEEAKKKAKDqkEEDRRNYPTNTYKTLELEIAESDVKVKEAELELVKEEA 362

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 119586555  967 EKHATENKVKNLTEEMAGLDEIIAKLTK----EKKALQEAHQQAlddlqAEEDKV 1017
Cdd:NF033838  363 KEPRNEEKIKQAKAKVESKKAEATRLEKiktdRKKAEEEAKRKA-----AEEDKV 412
growth_prot_Scy NF041483
polarized growth protein Scy;
840-1811 3.67e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 42.51  E-value: 3.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  840 LKSAE--REKEMASMKEEFTRL-KEALEKSEARRKELEEKMVSLLQEKNDLQLQVqAEQDNLADAEERCDQLIK------ 910
Cdd:NF041483  296 LASAEsaNEQRTRTAKEEIARLvGEATKEAEALKAEAEQALADARAEAEKLVAEA-AEKARTVAAEDTAAQLAKaartae 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  911 ---NKIQLEAK-----VKEMNERLEDEEEMNAE-LTAKKRKLEDECS-ELKRDIDDLELTLAKVEKEKHATENKVKNLTE 980
Cdd:NF041483  375 evlTKASEDAKattraAAEEAERIRREAEAEADrLRGEAADQAEQLKgAAKDDTKEYRAKTVELQEEARRLRGEAEQLRA 454

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  981 EMAGLDEIIakltkEKKALQEAHQQALDDLQAEEDkvnTLTKAKVkleqQVDDLEGSLEQE-KKVRMD-LERA---KRKL 1055
Cdd:NF041483  455 EAVAEGERI-----RGEARREAVQQIEEAARTAEE---LLTKAKA----DADELRSTATAEsERVRTEaIERAttlRRQA 522

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1056 EGDLKLTQESIMDLENDKQQLDERLKKkDFELNALNARIEDEQALGSQLQKKLKELqARIEELEEE-----LEAERTARA 1130
Cdd:NF041483  523 EETLERTRAEAERLRAEAEEQAEEVRA-AAERAARELREETERAIAARQAEAAEEL-TRLHTEAEErltaaEEALADARA 600

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1131 KVEKLRSDLSRELEEIseRLEEAGGATSVQiemnKKREAEFQKMRR----DLEEATLQHEATAAALRKKHADSVAEL-GE 1205
Cdd:NF041483  601 EAERIRREAAEETERL--RTEAAERIRTLQ----AQAEQEAERLRTeaaaDASAARAEGENVAVRLRSEAAAEAERLkSE 674

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1206 QIDNLQRVKqklekekSEFKLELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVND-----LTSQRAK 1280
Cdd:NF041483  675 AQESADRVR-------AEAAAAAERVGTEAAEALAAAQEEAARRRREAEETLGSARAEADQERERAREqseelLASARKR 747

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1281 LQTENGELSRQLDEKEALISQLTRGKLTYTQQLED----LKRQLEEEVKA-KNALAHALQSARhdcdllreqyeeeTEAK 1355
Cdd:NF041483  748 VEEAQAEAQRLVEEADRRATELVSAAEQTAQQVRDsvagLQEQAEEEIAGlRSAAEHAAERTR-------------TEAQ 814

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1356 AELQRVLSKANSEvaqwRTKYETDAI---QRTEELEEAKKKLAQR-LQEAEEAVEAVNAKCSSLEKtkhRLQNEIEDLMV 1431
Cdd:NF041483  815 EEADRVRSDAYAE----RERASEDANrlrREAQEETEAAKALAERtVSEAIAEAERLRSDASEYAQ---RVRTEASDTLA 887

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1432 DVERSNAAAAALDKKQRNfdKILAEwkqkyeeSQSELESSQKEARSLSTELFKLKNAYEESLehLETFKRENKNLQEEIS 1511
Cdd:NF041483  888 SAEQDAARTRADAREDAN--RIRSD-------AAAQADRLIGEATSEAERLTAEARAEAERL--RDEARAEAERVRADAA 956

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1512 DLTEQLGSsgKTIHELEKVRK---------QLEAEKMELQSALEEAEASLEHEEgkiLRAQlefnqIKAEIERKLAEKDE 1582
Cdd:NF041483  957 AQAEQLIA--EATGEAERLRAeaaetvgsaQQHAERIRTEAERVKAEAAAEAER---LRTE-----AREEADRTLDEARK 1026

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1583 EMEQAKRNHLRVVDSLQTSLDAE-----TRSRNEALRVKKKMEGDLNEM-EIQLSHANRMAAEAQKQVKSLQSLLKDTQI 1656
Cdd:NF041483 1027 DANKRRSEAAEQADTLITEAAAEadqltAKAQEEALRTTTEAEAQADTMvGAARKEAERIVAEATVEGNSLVEKARTDAD 1106

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1657 QLDDAVRanddlKENIAIVERRNNL---LQAELEEL--RAVVEQTERSR----------KLAEQELIETSERVQLLHSQN 1721
Cdd:NF041483 1107 ELLVGAR-----RDATAIRERAEELrdrITGEIEELheRARRESAEQMKsagercdalvKAAEEQLAEAEAKAKELVSDA 1181

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1722 TS-----LINQKKKMDADLSQLQTEVEEAVQEcrnAEEKAKKAITDAAMMAEELKKEQDTsahLERMKKNMEQTIKDLQH 1796
Cdd:NF041483 1182 NSeaskvRIAAVKKAEGLLKEAEQKKAELVRE---AEKIKAEAEAEAKRTVEEGKRELDV---LVRRREDINAEISRVQD 1255

                        1050
                  ....*....|....*
gi 119586555 1797 RLDEAEQIALKGGKK 1811
Cdd:NF041483 1256 VLEALESFEAPSGGG 1270
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1255-1448 4.14e-03

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 42.51  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1255 DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEkealISQlTRGKLTYTQQledlkrqleeevkakNALAHAL 1334
Cdd:NF012221 1545 DAVSKHAKQDDAAQNALADKERAEADRQRLEQEKQQQLAA----ISG-SQSQLESTDQ---------------NALETNG 1604

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1335 QSARhdcDLLREQYEEETEAKAELQRVLSKANSEVA-------QWRTKYET---DAIQR---------TEELEEAKKKLA 1395
Cdd:NF012221 1605 QAQR---DAILEESRAVTKELTTLAQGLDALDSQATyagesgdQWRNPFAGgllDRVQEqlddakkisGKQLADAKQRHV 1681

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 119586555 1396 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNaaAAALDKKQR 1448
Cdd:NF012221 1682 DNQQKVKDAVAKSEAGVAQGEQNQANAEQDIDDAKADAEKRK--DDALAKQNE 1732
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 864-1001 6.10e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 40.82  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  864 EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDqliKNKIQLEAKVKEMNERLEDEEEMN-----AELTA 938
Cdd:cd22656   110 EELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTE---KDQTALETLEKALKDLLTDEGGAIarkeiKDLQK 186

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119586555  939 KKRKLEDEC-SELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1001
Cdd:cd22656   187 ELEKLNEEYaAKLKAKIDELKALIADDEAKLAAALRLIADLTAADTDLDNLLALIGPAIPALEK 250
growth_prot_Scy NF041483
polarized growth protein Scy;
1353-1857 7.71e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 41.35  E-value: 7.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1353 EAKAELQRVLSKANSEVAQWRTKYETDAIQRTeelEEAKKKLAQRLQEAEEAVEAVNAKCsslEKTKHRLQNEIEDLMVD 1432
Cdd:NF041483  276 EARAEAEKVVAEAKEAAAKQLASAESANEQRT---RTAKEEIARLVGEATKEAEALKAEA---EQALADARAEAEKLVAE 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1433 VE---RSNAA---AAALDKKQRNFDKILAEwkqkyeesqselesSQKEARSLStelfklKNAYEESLEHLETFKRENKNL 1506
Cdd:NF041483  350 AAekaRTVAAedtAAQLAKAARTAEEVLTK--------------ASEDAKATT------RAAAEEAERIRREAEAEADRL 409

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1507 QEEISDLTEQLGSSGKtiheleKVRKQLEAEKMELQSaleeaEASLEHEEGKILRAQL--EFNQIKAEIERKLAEKDEEM 1584
Cdd:NF041483  410 RGEAADQAEQLKGAAK------DDTKEYRAKTVELQE-----EARRLRGEAEQLRAEAvaEGERIRGEARREAVQQIEEA 478

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1585 EQAKRNHLRV----VDSLQTSLDAET-RSRNEALRVKKKMEGDLNE-MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1658
Cdd:NF041483  479 ARTAEELLTKakadADELRSTATAESeRVRTEAIERATTLRRQAEEtLERTRAEAERLRAEAEEQAEEVRAAAERAAREL 558

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1659 -DDAVRANDDLKENIAIVERRnnlLQAELEELRAVVEQT--------ERSRKLAEQEL----IETSERVQLLHSQntsli 1725
Cdd:NF041483  559 rEETERAIAARQAEAAEELTR---LHTEAEERLTAAEEAladaraeaERIRREAAEETerlrTEAAERIRTLQAQ----- 630

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1726 nqkkkMDADLSQLQTE-VEEAVQECRNAEEKAKKAITDAAMMAEELKKE-QDTS--------AHLERMKKNMEQTIKDLQ 1795
Cdd:NF041483  631 -----AEQEAERLRTEaAADASAARAEGENVAVRLRSEAAAEAERLKSEaQESAdrvraeaaAAAERVGTEAAEALAAAQ 705

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555 1796 H----RLDEAEQIaLKGGKKQLQKLEARVRELENELEAEQKR-----NAESVKGMRKSERRIKELTYQTEE 1857
Cdd:NF041483  706 EeaarRRREAEET-LGSARAEADQERERAREQSEELLASARKrveeaQAEAQRLVEEADRRATELVSAAEQ 775
 
Name Accession Description Interval E-value
MYSc_Myh7 cd14917
class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I ...
 99-766 0e+00

class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I cardiac muscle myosin heavy chain 7 (also called CMH1, MPD1, and CMD1S). Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. It is expressed predominantly in normal human ventrical and in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276881 [Multi-domain]  Cd Length: 668  Bit Score: 1388.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14917     1 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14917    81 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14917   161 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14917   241 LGFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14917   321 QVIYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14917   401 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSNNFQKPRNIKGKPEAHFS 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14917   481 LIHYAGTVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14917   561 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 640

                         650       660
                  ....*....|....*....|....*...
gi 119586555  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14917   641 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 668
MYSc_class_II cd01377
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
 99-766 0e+00

class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276951 [Multi-domain]  Cd Length: 662  Bit Score: 1353.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd01377     1 ASVLHNLRERYYSDLIYTYSGLFCVAVNPYKRLPIYTEEVIDKYKGKRREEMPPHIFAIADNAYRNMLQDRENQSILITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDrSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd01377    81 ESGAGKTENTKKVIQYLASVAASSK-KKKESGKKKGTLEDQILQANPILEAFGNAKTVRNNNSSRFGKFIRIHFGSTGKI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd01377   160 AGADIETYLLEKSRVVRQAKGERNYHIFYQLLSGADPELKEKLLLTGDPSYYFFLSQGELTIDGVDDAEEFKLTDEAFDI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd01377   240 LGFSEEEKMSIFKIVAAILHLGNIKFKQRRREEQAELDGTEEADKAAHLLGVNSSDLLKALLKPRIKVGREWVTKGQNKE 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd01377   320 QVVFSVGALAKALYERLFLWLVKRINKTLDTKSKRQYFIGVLDIAGFEIFEFNSFEQLCINYTNEKLQQFFNHHMFVLEQ 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKP-MGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRniKGKPEAHF 577
Cdd:cd01377   400 EEYKKEGIEWTFIDFGLDLQPTIDLIEKPnMGILSILDEECVFPKATDKTFVEKLYSNHLGKSKNFKKPK--PKKSEAHF 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  578 SLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApieKGKGKAKKGSSFQTVSALHRENLNK 657
Cdd:cd01377   478 ILKHYAGDVEYNIDGWLEKNKDPLNENVVALLKKSSDPLVASLFKDYEESGG---GGGKKKKKGGSFRTVSQLHKEQLNK 554

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  658 LMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFiD 737
Cdd:cd01377   555 LMTTLRSTHPHFVRCIIPNEEKKPGKIDAPLVLHQLRCNGVLEGIRICRKGFPNRIIFAEFKQRYSILAPNAIPKGFD-D 633

                         650       660
                  ....*....|....*....|....*....
gi 119586555  738 SRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01377   634 GKAACEKILKALQLDPELYRIGNTKVFFK 662
MYSc_Myh3 cd14913
class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle ...
 99-766 0e+00

class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle myosin heavy chain 3 (MYHC-EMB, MYHSE1, HEMHC, SMHCE) in tetrapods including mammals, lizards, and frogs. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276878 [Multi-domain]  Cd Length: 668  Bit Score: 1312.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14913     1 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14913    81 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14913   161 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14913   241 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14913   321 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14913   401 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFS 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14913   481 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKL 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14913   561 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDS 640

                         650       660
                  ....*....|....*....|....*...
gi 119586555  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14913   641 KKACEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_Myh6 cd14916
class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac ...
 99-766 0e+00

class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac muscle myosin heavy chain 6. Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276880 [Multi-domain]  Cd Length: 670  Bit Score: 1246.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14916     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQS-PGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257
Cdd:cd14916    81 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPnANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  258 LASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFD 337
Cdd:cd14916   161 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  338 VLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNV 417
Cdd:cd14916   241 VLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  418 QQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 497
Cdd:cd14916   321 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  498 QEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHF 577
Cdd:cd14916   401 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  578 SLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIE-KGKGKAKKGSSFQTVSALHRENLN 656
Cdd:cd14916   481 SLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSgKGKGGKKKGSSFQTVSALHRENLN 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  657 KLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 736
Cdd:cd14916   561 KLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 640

                         650       660       670
                  ....*....|....*....|....*....|
gi 119586555  737 DSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14916   641 DSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 670
MYSc_Myh7b cd14927
class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta ...
 100-766 0e+00

class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta myosin heavy chain 7b (also called KIAA1512, dJ756N5.1, MYH14, MHC14). MYH7B is a slow-twitch myosin. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276953 [Multi-domain]  Cd Length: 676  Bit Score: 1229.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14927     2 SVLHNLRRRYSRWMIYTYSGLFCVTVNPYKWLPVYTAPVVAAYKGKRRSEAPPHIYAIADNAYNDMLRNRENQSMLITGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIAAIGDR-SKKDQSPGK---GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT 255
Cdd:cd14927    82 SGAGKTVNTKRVIQYFAIVAALGDGpGKKAQFLATktgGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  256 GKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNA 335
Cdd:cd14927   162 GKLASADIDIYLLEKSRVIFQQPGERSYHIYYQILSGKKPELQDMLLVSMNPYDYHFCSQGVTTVDNMDDGEELMATDHA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  336 FDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
Cdd:cd14927   242 MDILGFSPDEKYGCYKIVGAIMHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSADLLKGLLHPRVKVGNEYVTKGQ 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  416 NVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd14927   322 SVEQVVYAVGALAKATYDRMFKWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFI 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  496 LEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPR-NIKGKPE 574
Cdd:cd14927   402 LEQEEYKREGIEWVFIDFGLDLQACIDLIEKPLGILSILEEECMFPKASDASFKAKLYDNHLGKSPNFQKPRpDKKRKYE 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  575 AHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADA---PIEKGKGKAKKGSSFQTVSALH 651
Cdd:cd14927   482 AHFEVVHYAGVVPYNIVGWLDKNKDPLNETVVAIFQKSQNKLLATLYENYVGSDStedPKSGVKEKRKKAASFQTVSQLH 561

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  652 RENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIP 731
Cdd:cd14927   562 KENLNKLMTNLRATQPHFVRCIIPNETKTPGVMDPFLVLHQLRCNGVLEGIRICRKGFPNRILYADFKQRYRILNPSAIP 641

                         650       660       670
                  ....*....|....*....|....*....|....*
gi 119586555  732 EGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14927   642 DDKFVDSRKATEKLLGSLDIDHTQYQFGHTKVFFK 676
MYSc_Myh13 cd14923
class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin ...
 99-766 0e+00

class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 13 (also called MyHC-eo) in mammals, chicken, and green anole. Myh13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement. Class II myosins, also called conventional myosins, are the myosin type responsible for producing muscle contraction in muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276887 [Multi-domain]  Cd Length: 671  Bit Score: 1155.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14923     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRsKKDQSPGK--GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14923    81 ESGAGKTVNTKRVIQYFATIAVTGDK-KKEQQPGKmqGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14923   160 KLASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd14923   240 DILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQN 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14923   320 VQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAH 576
Cdd:cd14923   400 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAH 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  577 FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIE--KGKGKAKKGSSFQTVSALHREN 654
Cdd:cd14923   480 FSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAEAGDSggSKKGGKKKGSSFQTVSAVFREN 559

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  655 LNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQ 734
Cdd:cd14923   560 LNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEGQ 639

                         650       660       670
                  ....*....|....*....|....*....|..
gi 119586555  735 FIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14923   640 FIDSKNASEKLLNSIDVDREQYRFGHTKVFFK 671
MYSc_Myh8 cd14918
class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle ...
 99-766 0e+00

class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle myosin heavy chain 8 (also called MyHC-peri, MyHC-pn). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276882 [Multi-domain]  Cd Length: 668  Bit Score: 1152.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14918     1 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14918    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14918   161 ASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDI 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14918   241 LGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTVQ 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14918   321 QVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQ 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14918   401 EEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFS 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14918   481 LIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADSGAKKGAKKKGSSFQTVSALFRENLNKL 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14918   561 MTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFIDS 640

                         650       660
                  ....*....|....*....|....*...
gi 119586555  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14918   641 KKASEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_Myh2_mammals cd14912
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
 99-766 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in mammals. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276877 [Multi-domain]  Cd Length: 673  Bit Score: 1129.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14912     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGK--GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14912    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14912   161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAI 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd14912   241 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14912   321 VEQVTNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAH 576
Cdd:cd14912   401 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAH 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  577 FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGAD---APIEKGKGKAKKGSSFQTVSALHRE 653
Cdd:cd14912   481 FSLIHYAGVVDYNITGWLDKNKDPLNETVVGLYQKSAMKTLAYLFSGAQTAEgasAGGGAKKGGKKKGSSFQTVSALFRE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  654 NLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEG 733
Cdd:cd14912   561 NLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEG 640

                         650       660       670
                  ....*....|....*....|....*....|...
gi 119586555  734 QFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14912   641 QFIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 673
MYSc_Myh1_mammals cd14910
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
 99-766 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in mammals. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276875 [Multi-domain]  Cd Length: 671  Bit Score: 1127.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14910     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGK--GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14910    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEATSGKmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14910   161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAI 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd14910   241 EILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14910   321 VQQVYNAVGALAKAVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAH 576
Cdd:cd14910   401 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAH 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  577 FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPI-EKGKGKAKKGSSFQTVSALHRENL 655
Cdd:cd14910   481 FSLIHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLALLFSGAAAAEAEEgGGKKGGKKKGSSFQTVSALFRENL 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  656 NKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 735
Cdd:cd14910   561 NKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQF 640

                         650       660       670
                  ....*....|....*....|....*....|.
gi 119586555  736 IDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14910   641 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
MYSc_Myh4 cd14915
class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin ...
 99-766 0e+00

class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 4 (also called MYH2B, MyHC-2B, MyHC-IIb). Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276879 [Multi-domain]  Cd Length: 671  Bit Score: 1127.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14915     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGK--GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14915    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEAASGKmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14915   161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELMATDSAV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd14915   241 DILGFSADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14915   321 VQQVYNSVGALAKAIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAH 576
Cdd:cd14915   401 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKAEAH 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  577 FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAP-IEKGKGKAKKGSSFQTVSALHRENL 655
Cdd:cd14915   481 FSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSGMKTLAFLFSGGQTAEAEgGGGKKGGKKKGSSFQTVSALFRENL 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  656 NKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 735
Cdd:cd14915   561 NKLMTNLRSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQF 640

                         650       660       670
                  ....*....|....*....|....*....|.
gi 119586555  736 IDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14915   641 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
Myosin_head pfam00063
Myosin head (motor domain);
87-766 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 1083.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    87 IEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYML 166
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   167 TDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKkdqspgKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGK 246
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSGSGSAGN------VGRLEEQILQSNPILEAFGNAKTVRNNNSSRFGK 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   247 FIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITnNPYDYAFISQ-GETTVASIDD 325
Cdd:pfam00063  155 YIEIQFDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGASAQLKKELRLT-NPKDYHYLSQsGCYTIDGIDD 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   326 AEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVK 405
Cdd:pfam00063  234 SEEFKITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRRIK 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   406 VGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQ-PRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEK 484
Cdd:pfam00063  314 TGRETVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDVKTiEKASFIGVLDIYGFEIFEKNSFEQLCINYVNEK 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   485 LQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANF 563
Cdd:pfam00063  394 LQQFFNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYSTF-SKHPHF 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   564 QKPRNIKgkpEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAK---- 639
Cdd:pfam00063  472 QKPRLQG---ETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFPDYETAESAAANESGKSTpkrt 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   640 KGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFR 719
Cdd:pfam00063  549 KKKRFITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQEFV 628

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 119586555   720 QRYRILNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:pfam00063  629 QRYRILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc_Myh15_mammals cd14929
class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy ...
 99-766 0e+00

class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy chain 15 in mammals (also called KIAA1000) . MYH15 is a slow-twitch myosin. Myh15 is a ventricular myosin heavy chain. Myh15 is absent in embryonic and fetal muscles and is found in orbital layer of extraocular muscles at birth. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276892 [Multi-domain]  Cd Length: 662  Bit Score: 1076.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14929     1 ASVLHTLRRRYDHWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKdqspgKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14929    81 ESGAGKTVNTKHIIQYFATIAAMIESKKK-----LGALEDQIMQANPVLEAFGNAKTLRNDNSSRFGKFIRMHFGARGML 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKpELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14929   156 SSADIDIYLLEKSRVIFQQPGERNYHIFYQILSGKK-ELRDLLLVSANPSDFHFCSCGAVAVESLDDAEELLATEQAMDI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14929   235 LGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKGLIHPRIKVGNEYVTRSQNIE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14929   315 QVTYAVGALSKSIYERMFKWLVARINRVLDAKLSRQFFIGILDITGFEILDYNSLEQLCINFTNEKLQQFFNQHMFVLEQ 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14929   395 EEYRKEGIDWVSIDFGLDLQACIDLIEKPMGIFSILEEECMFPKATDLTFKTKLFDNHFGKSVHFQKPKPDKKKFEAHFE 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14929   475 LVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYISTDSAIQFGEKKRKKGASFQTVASLHKENLNKL 554

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14929   555 MTNLKSTAPHFVRCINPNVNKIPGVLDPYLVLQQLRCNGVLEGIRICREGFPNRLLYADFKQRYCILNPRTFPKSKFVSS 634

                         650       660
                  ....*....|....*....|....*...
gi 119586555  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14929   635 RKAAEELLGSLEIDHTQYRFGITKVFFK 662
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
 80-778 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 1029.80  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555     80 NPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISD 159
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    160 NAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAigdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRND 239
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVSG--------SNTEVGSVEDQILESNPILEAFGNAKTLRNN 152

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    240 NSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGET- 318
Cdd:smart00242  153 NSSRFGKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGASEELKKELGLKS-PEDYRYLNQGGCl 231

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    319 TVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQA-EPDGTEEADKSAYLMGLNSADLLK 397
Cdd:smart00242  232 TVDGIDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAAsTVKDKEELSNAAELLGVDPEELEK 311

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    398 GLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLC 477
Cdd:smart00242  312 ALTKRKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQLC 391

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    478 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLfDNH 556
Cdd:smart00242  392 INYANEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKL-NQH 469

                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    557 LGKSANFQKPRNikgKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGadapiekgkg 636
Cdd:smart00242  470 HKKHPHFSKPKK---KGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLFPSGVS---------- 536

                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    637 KAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 716
Cdd:smart00242  537 NAGSKKRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLPFD 616

                           650       660       670       680       690       700
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119586555    717 DFRQRYRILNPAAIPEGQFiDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRD 778
Cdd:smart00242  617 EFLQRYRVLLPDTWPPWGG-DAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
MYSc_Myh1_insects_crustaceans cd14909
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
 99-766 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in insects and crustaceans. Myh1 is a type I skeletal muscle myosin that in Humans is encoded by the MYH1 gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276874  Cd Length: 666  Bit Score: 1017.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14909     1 ASVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAigDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14909    81 ESGAGKTENTKKVIAYFATVGA--SKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14909   159 AGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKEMCLLSDNIYDYYIVSQGKVTVPNVDDGEEFSLTDQAFDI 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14909   239 LGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQ 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14909   319 QVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQ 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIK-GKPEAHF 577
Cdd:cd14909   399 EEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKpGQQAAHF 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  578 SLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADA-PIEKGKGKAKKGSSFQTVSALHRENLN 656
Cdd:cd14909   479 AIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGgGEQAKGGRGKKGGGFATVSSAYKEQLN 558

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  657 KLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQfi 736
Cdd:cd14909   559 SLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKILNPAGIQGEE-- 636

                         650       660       670
                  ....*....|....*....|....*....|
gi 119586555  737 DSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14909   637 DPKKAAEIILESIALDPDQYRLGHTKVFFR 666
MYSc_Myh16 cd14934
class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 ...
 100-766 0e+00

class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 pseudogene (also called MHC20, MYH16, and myh5), encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. This cd contains Myh16 in mammals. MYH16 has intermediate fibres between that of slow type 1 and fast 2B fibres, but exert more force than any other fibre type examined. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276896 [Multi-domain]  Cd Length: 659  Bit Score: 1012.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14934     2 SVLDNLRQRYTNMRIYTYSGLFCVTVNPYKWLPIYGARVANMYKGKKRTEMPPHLFSISDNAYHDMLMDRENQSMLITGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIAAIGdrskKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14934    82 SGAGKTENTKKVIQYFANIGGTG----KQSSDGKGSLEDQIIQANPVLEAFGNAKTTRNNNSSRFGKFIRIHFGTTGKLA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDVL 339
Cdd:cd14934   158 GADIESYLLEKSRVISQQAAERGYHIFYQILSNKKPELIESLLLVPNPKEYHWVSQGVTVVDNMDDGEELQITDVAFDVL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  340 GFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQ 419
Cdd:cd14934   238 GFSAEEKIGVYKLTGGIMHFGNMKFKQKPREEQAEVDTTEVADKVAHLMGLNSGELQKGITRPRVKVGNEFVQKGQNMEQ 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  420 VIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQE 499
Cdd:cd14934   318 CNNSIGALGKAVYDKMFKWLVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFVLEQE 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  500 EYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGK-PEAHFS 578
Cdd:cd14934   398 EYKREGIEWVFIDFGLDLQACIDLLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSSNFLKPKGGKGKgPEAHFE 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApiekgKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14934   478 LVHYAGTVGYNITGWLEKNKDPLNETVVGLFQKSSLGLLALLFKEEEAPAG-----SKKQKRGSSFMTVSNFYREQLNKL 552

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGqFIDS 738
Cdd:cd14934   553 MTTLHSTAPHFVRCIVPNEFKQSGVVDAHLIMHQLACNGVLEGIRICRKGFPNRLQYPEFKQRYQVLNPNVIPQG-FVDN 631

                         650       660
                  ....*....|....*....|....*...
gi 119586555  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14934   632 KKASELLLGSIDLDVNEYKIGHTKVFFR 659
COG5022 COG5022
Myosin heavy chain [General function prediction only];
37-1433 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 858.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   37 VFVPDDKQEFVKAKIVSRE--GGKVTAE--TEYGKTVTVKEDQVMQ--QNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYG 110
Cdd:COG5022    12 CWIPDEEKGWIWAEIIKEAfnKGKVTEEgkKEDGESVSVKKKVLGNdrIKLPKFDGVDDLTELSYLNEPAVLHNLEKRYN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  111 SWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKR 190
Cdd:COG5022    92 NGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGKTENAKR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  191 VIQYFAVIAAIgdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEK 270
Cdd:COG5022   172 IMQYLASVTSS-------STVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKIETYLLEK 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  271 SRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGE-TTVASIDDAEELMATDNAFDVLGFTSEEKNSM 349
Cdd:COG5022   245 SRVVHQNKNERNYHIFYQLLAGDPEELKKLLLLQN-PKDYIYLSQGGcDKIDGIDDAKEFKITLDALKTIGIDEEEQDQI 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  350 YKLTGAIMHFGNMKFKlKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAK 429
Cdd:COG5022   324 FKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALAIRDSLAK 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  430 AVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWT 509
Cdd:COG5022   403 ALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYVKEGIEWS 482

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  510 FIDFgMDLQACIDLIEK--PMGIMSILEEECMFPKATDMTFKAKLFDN-HLGKSANFQKPRNIKGKpeahFSLIHYAGIV 586
Cdd:COG5022   483 FIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK----FVVKHYAGDV 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  587 DYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADapiekgkgkakKGSSFQTVSALHRENLNKLMTNLRSTH 666
Cdd:COG5022   558 EYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEENIE-----------SKGRFPTLGSRFKESLNSLMSTLNSTQ 626

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  667 PHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI---DSRKGAE 743
Cdd:COG5022   627 PHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTwkeDTKNAVK 706

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  744 KLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMG 823
Cdd:COG5022   707 SILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRLRRL 786

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  824 VKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEK----SEARRKELEEKMVSLLQE---------------K 884
Cdd:COG5022   787 VDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQKTIKRekklRETEEVEFSLKAEVLIQKfgrslkakkrfsllkK 866

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  885 NDLQLQVQAEQDNL--------ADAEER----------------------CDQLIKNKIQLE--AKVKEMNE--RLEDEE 930
Cdd:COG5022   867 ETIYLQSAQRVELAerqlqelkIDVKSIsslklvnleleseiielkkslsSDLIENLEFKTEliARLKKLLNniDLEEGP 946

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  931 EMNAELTAKKRKLEDECSELKRDIDDLELTLakveKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ----- 1005
Cdd:COG5022   947 SIEYVKLPELNKLHEVESKLKETSEEYEDLL----KKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQlkelp 1022

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1006 -ALDDLQAEEDKVNTLTKAKvKLEQQVDDLEGSLEQEKK------VRMDLERAKRKLEGDLKLTQESIMDLEN-----DK 1073
Cdd:COG5022  1023 vEVAELQSASKIISSESTEL-SILKPLQKLKGLLLLENNqlqaryKALKLRRENSLLDDKQLYQLESTENLLKtinvkDL 1101

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1074 QQLDERLKKKDFELNAL------NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS 1147
Cdd:COG5022  1102 EVTNRNLVKPANVLQFIvaqmikLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKR 1181

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1148 ER----LEEAGGATSVQIEMnKKREAEFqKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Cdd:COG5022  1182 LYqsalYDEKSKLSSSEVND-LKNELIA-LFSKIFSGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKKFDTPASMSNE 1259

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1224 fklELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEHrskaeetqrSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1303
Cdd:COG5022  1260 ---KLLSLLNSIDNLLSSYKLEEEVLPATINSLLQYI---------NVGLFNALRTKASSLRWKSATEVNYNSEELDDWC 1327

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1304 RgkltyTQQLEDLKRQLE---EEVKAKNALAHALQSARHDCDLLREQYEEETEA-KAELQRVLSKANSEvAQWRTKYETD 1379
Cdd:COG5022  1328 R-----EFEISDVDEELEeliQAVKVLQLLKDDLNKLDELLDACYSLNPAEIQNlKSRYDPADKENNLP-KEILKKIEAL 1401

                        1450      1460      1470      1480      1490
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555 1380 AIQRTEELE-EAKKKLAQRLQE-AEEAVEAVNAKCSSLEKTKhRLQNEIEDLMVDV 1433
Cdd:COG5022  1402 LIKQELQLSlEGKDETEVHLSEiFSEEKSLISLDRNSIYKEE-VLSSLSALLTKEK 1456
MYSc cd00124
Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase ...
 99-766 0e+00

Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276950 [Multi-domain]  Cd Length: 633  Bit Score: 845.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKR-SEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd00124     1 AAILHNLRERYARDLIYTYVGDILVAVNPFKWLPLYSEEVMEKYRGKGRsADLPPHVFAVADAAYRAMLRDGQNQSILIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  178 GESGAGKTVNTKRVIQYFAVIAAigdRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257
Cdd:cd00124    81 GESGAGKTETTKLVLKYLAALSG---SGSSKSSSSASSIEQQILQSNPILEAFGNAKTVRNDNSSRFGKFIELQFDPTGR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  258 LASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLIT---NNPYDYAFISQGE-TTVASIDDAEELMATD 333
Cdd:cd00124   158 LVGASIETYLLEKSRVVSQAPGERNFHIFYQLLAGLSDGAREELKLElllSYYYLNDYLNSSGcDRIDGVDDAEEFQELL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  334 NAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREE--QAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYV 411
Cdd:cd00124   238 DALDVLGFSDEEQDSIFRILAAILHLGNIEFEEDEEDEdsSAEVADDESLKAAAKLLGVDAEDLEEALTTRTIKVGGETI 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  412 TKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL--ETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFF 489
Cdd:cd00124   318 TKPLTVEQAEDARDALAKALYSRLFDWLVNRINAALspTDAAESTSFIGILDIFGFENFEVNSFEQLCINYANEKLQQFF 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  490 NHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRn 568
Cdd:cd00124   398 NQHVFKLEQEEYEEEGIDWSFIDF-PDNQDCLDLIEgKPLGILSLLDEECLFPKGTDATFLEKLYSAHGSHPRFFSKKR- 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  569 ikgKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSlkllstlfanyagadapiekgkgkakkgssfqtvs 648
Cdd:cd00124   476 ---KAKLEFGIKHYAGDVTYDADGFLEKNKDTLPPDLVDLLRSGS----------------------------------- 517

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  649 aLHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPA 728
Cdd:cd00124   518 -QFRSQLDALMDTLNSTQPHFVRCIKPNDEKKPGLFDPELVLEQLRCAGVLEAVRIRRAGYPVRLPFDEFLKRYRILAPG 596

                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 119586555  729 AiPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd00124   597 A-TEKASDSKKAAVLALLLLLKLDSSGYQLGKTKVFLR 633
MYSc_Myh2_insects_mollusks cd14911
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
 100-766 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in insects and mollusks. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276876 [Multi-domain]  Cd Length: 674  Bit Score: 807.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14911     2 SVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIAAigDRSKKDQSPGK---------GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRI 250
Cdd:cd14911    82 SGAGKTENTKKVIQFLAYVAA--SKPKGSGAVPHpavnpavliGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  251 HFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItNNPYDYAFISQGETTVASIDDAEELM 330
Cdd:cd14911   160 NFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQ 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  331 ATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTEeADKSAYLMGLNSADLLKGLCHPRVKVGNE 409
Cdd:cd14911   239 ATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATlPDNTV-AQKIAHLLGLSVTDMTRAFLTPRIKVGRD 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  410 YVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQF 488
Cdd:cd14911   318 FVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDrTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQL 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  489 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLgksanfQKPRN 568
Cdd:cd14911   398 FNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHS------MHPKF 471

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  569 IKG--KPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY----AGADAPIEKGKGKAKKGS 642
Cdd:cd14911   472 MKTdfRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAeivgMAQQALTDTQFGARTRKG 551

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  643 SFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRY 722
Cdd:cd14911   552 MFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRY 631

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 119586555  723 RILNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14911   632 ELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQSKIFFR 674
MYSc_Myh10 cd14920
class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy ...
 100-766 0e+00

class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy chain 10 (also called NMMHCB). Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276952 [Multi-domain]  Cd Length: 673  Bit Score: 772.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14920     2 SVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14920    82 SGAGKTENTKKVIQYLAHVASSHKGRKDHNIPGE--LERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPEL-LDMLLITNNpyDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14920   160 GANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLkSDLLLEGFN--NYRFLSNGYIPIPGQQDKDNFQETMEAMHI 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTeEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNV 417
Cdd:cd14920   238 MGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASmPENT-VAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTK 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  418 QQVIYATGALAKAVYERMFNWMVTRINATLETKQpRQ--YFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd14920   317 EQADFAVEALAKATYERLFRWLVHRINKALDRTK-RQgaSFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFI 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  496 LEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFdNHLGKSANFQKPRNIKGk 572
Cdd:cd14920   396 LEQEEYQREGIEWNFIDFGLDLQPCIDLIERPAnppGVLALLDEECWFPKATDKTFVEKLV-QEQGSHSKFQKPRQLKD- 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  573 pEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFAN---YAGAD----APIEKGKGKAKKGSS-F 644
Cdd:cd14920   474 -KADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDvdrIVGLDqvtgMTETAFGSAYKTKKGmF 552

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  645 QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 724
Cdd:cd14920   553 RTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEI 632

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 119586555  725 LNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14920   633 LTPNAIPKG-FMDGKQACERMIRALELDPNLYRIGQSKIFFR 673
MYSc_Myh18 cd14932
class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain ...
 100-766 0e+00

class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain 18. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276895 [Multi-domain]  Cd Length: 676  Bit Score: 721.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14932     2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKYLPIYSEEIVNMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIAAiGDRSKKDQSP---GKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14932    82 SGAGKTENTKKVIQYLAYVAS-SFKTKKDQSSialSHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPyDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14932   161 YIVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLRSELCLEDYS-KYRFLSNGNVTIPGQQDKELFAETMEAF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTeEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
Cdd:cd14932   240 RIMSIPEEEQTGLLKVVSAVLQLGNMSFKKERNSDQASmPDDT-AAQKVCHLLGMNVTDFTRAILSPRIKVGRDYVQKAQ 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  416 NVQQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 494
Cdd:cd14932   319 TQEQAEFAVEALAKASYERMFRWLVMRINKALDkTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMF 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  495 VLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFdNHLGKSANFQKPRNIKG 571
Cdd:cd14932   399 ILEQEEYQREGIEWSFIDFGLDLQPCIELIEKPNgppGILALLDEECWFPKATDKSFVEKVV-QEQGNNPKFQKPKKLKD 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  572 kpEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY---AGADA----PIEKGKGKAKKGSSF 644
Cdd:cd14932   478 --DADFCIIHYAGKVDYKANEWLMKNMDPLNENVATLLNQSTDKFVSELWKDVdriVGLDKvagmGESLHGAFKTRKGMF 555

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  645 QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 724
Cdd:cd14932   556 RTVGQLYKEQLMNLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEI 635

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 119586555  725 LNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14932   636 LTPNAIPKG-FMDGKQACVLMVKALELDPNLYRIGQSKVFFR 676
MYSc_Myo5 cd01380
class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins ...
 99-766 0e+00

class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins that transport a variety of intracellular cargo processively along actin filaments, such as melanosomes, synaptic vesicles, vacuoles, and mRNA. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains a IQ domain and a globular DIL domain. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Note that the Dictyostelium myoVs are not contained in this child group. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276831 [Multi-domain]  Cd Length: 629  Bit Score: 698.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYG-SWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd01380     1 PAVLHNLKVRFCqRNAIYTYCGIVLVAINPYEDLPIYGEDIIQAYSGQNMGELDPHIFAIAEEAYRQMARDEKNQSIIVS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  178 GESGAGKTVNTKRVIQYFAVIAaiGDRSKKDQspgkgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257
Cdd:cd01380    81 GESGAGKTVSAKYAMRYFATVG--GSSSGETQ------VEEKVLASNPIMEAFGNAKTTRNDNSSRFGKYIEILFDKNYR 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  258 LASADIETYLLEKSRVIFQLKAERDYHIFYQILSNK-KPELLDMLLITNNpyDYAFISQGE-TTVASIDDAEELMATDNA 335
Cdd:cd01380   153 IIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCAAAsLPELKELHLGSAE--DFFYTNQGGsPVIDGVDDAAEFEETRKA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  336 FDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
Cdd:cd01380   231 LTLLGISEEEQMEIFRILAAILHLGNVEIKATRNDSASISPDDEHLQIACELLGIDESQLAKWLCKRKIVTRSEVIVKPL 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  416 NVQQVIYATGALAKAVYERMFNWMVTRINATLETKQP--RQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHM 493
Cdd:cd01380   311 TLQQAIVARDALAKHIYAQLFDWIVDRINKALASPVKekQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHV 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  494 FVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGK-SANFQKPRNIKGK 572
Cdd:cd01380   391 FKLEQEEYVKEEIEWSFIDF-YDNQPCIDLIEGKLGILDLLDEECRLPKGSDENWAQKLYNQHLKKpNKHFKKPRFSNTA 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  573 peahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLlstlfanyagadapiekgkgkakkgssfQTVSALHR 652
Cdd:cd01380   470 ----FIVKHFADDVEYQVEGFLEKNRDTVSEEHLNVLKASKNRK----------------------------KTVGSQFR 517

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  653 ENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAipE 732
Cdd:cd01380   518 DSLILLMETLNSTTPHYVRCIKPNDEKLPFTFDPKRVVQQLRACGVLETIRISAAGFPSRWTYEEFFSRYRVLLPSK--E 595

                         650       660       670
                  ....*....|....*....|....*....|....
gi 119586555  733 GQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01380   596 WLRDDKKKTCENILENLILDPDKYQFGKTKIFFR 629
MYSc_Myh11 cd14921
class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin ...
 100-766 0e+00

class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin heavy chain 11 (also called SMMHC, SMHC). The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. Inversion of the MYH11 locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Mutations in MYH11 have been described in individuals with thoracic aortic aneurysms leading to acute aortic dissections with patent ductus arteriosus. MYH11 mutations are also thought to contribute to human colorectal cancer and are also associated with Peutz-Jeghers syndrome. The mutations found in human intestinal neoplasia result in unregulated proteins with constitutive motor activity, similar to the mutant myh11 zebrafish. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276885 [Multi-domain]  Cd Length: 673  Bit Score: 698.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14921     2 SVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIAAiGDRSKKDQSPgKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14921    82 SGAGKTENTKKVIQYLAVVAS-SHKGKKDTSI-TGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPyDYAFISQGETTVASIDDAEELMATDNAFDVL 339
Cdd:cd14921   160 GANIETYLLEKSRAIRQARDERTFHIFYYLIAGAKEKMRSDLLLEGFN-NYTFLSNGFVPIPAAQDDEMFQETLEAMSIM 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  340 GFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTeEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14921   239 GFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASmPDNT-AAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  419 QVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 497
Cdd:cd14921   318 QADFAIEALAKATYERLFRWILTRVNKALDkTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILE 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  498 QEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNIKGKPE 574
Cdd:cd14921   398 QEEYQREGIEWNFIDFGLDLQPCIELIERPNnppGVLALLDEECWFPKATDKSFVEKLCTEQ-GNHPKFQKPKQLKDKTE 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  575 ahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY---AGADAPIEKGKGKAKKGSS-----FQT 646
Cdd:cd14921   477 --FSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVdriVGLDQMAKMTESSLPSASKtkkgmFRT 554

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  647 VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 726
Cdd:cd14921   555 VGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILA 634

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 119586555  727 PAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14921   635 ANAIPKG-FMDGKQACILMIKALELDPNLYRIGQSKIFFR 673
MYSc_Myh9 cd14919
class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy ...
 100-766 0e+00

class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy chain 9 (also called NMMHCA, NMHC-II-A, MHA, FTNS, EPSTS, and DFNA17). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276883 [Multi-domain]  Cd Length: 670  Bit Score: 685.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14919     2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIAAiGDRSKKDQspgkGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14919    82 SGAGKTENTKKVIQYLAHVAS-SHKSKKDQ----GELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItnNPYD-YAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14919   157 GANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLL--EPYNkYRFLSNGHVTIPGQQDKDMFQETMEAMRI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTeEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNV 417
Cdd:cd14919   235 MGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASmPDNT-AAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTK 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  418 QQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14919   314 EQADFAIEALAKATYERMFRWLVLRINKALDkTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFIL 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNIKGKp 573
Cdd:cd14919   394 EQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAgppGILALLDEECWFPKATDKSFVEKVVQEQ-GTHPKFQKPKQLKDK- 471

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  574 eAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY---AGAD-----APIEKGKGKAKKGSSFQ 645
Cdd:cd14919   472 -ADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVdriIGLDqvagmSETALPGAFKTRKGMFR 550

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  646 TVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL 725
Cdd:cd14919   551 TVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEIL 630

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|.
gi 119586555  726 NPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14919   631 TPNSIPKG-FMDGKQACVLMIKALELDSNLYRIGQSKVFFR 670
MYSc_Myh19 cd15896
class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain ...
 100-766 0e+00

class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain 19. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276899 [Multi-domain]  Cd Length: 675  Bit Score: 680.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd15896     2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIAAiGDRSKKDQSP---GKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd15896    82 SGAGKTENTKKVIQYLAHVAS-SHKTKKDQNSlalSHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPyDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd15896   161 YIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLTGAGDKLRSELLLENYN-NYRFLSNGNVTIPGQQDKDLFTETMEAF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd15896   240 RIMGIPEDEQIGMLKVVASVLQLGNMSFKKERHTDQASMPDNTAAQKVCHLMGMNVTDFTRAILSPRIKVGRDYVQKAQT 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  417 VQQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd15896   320 QEQAEFAVEALAKATYERMFRWLVMRINKALDkTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFI 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  496 LEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNIKGk 572
Cdd:cd15896   400 LEQEEYQREGIEWSFIDFGLDLQPCIDLIEKPAsppGILALLDEECWFPKATDKSFVEKVLQEQ-GTHPKFFKPKKLKD- 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  573 pEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY---AGADAPI---EKGKGKAKKGSSFQT 646
Cdd:cd15896   478 -EADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLNQSTDKFVSELWKDVdriVGLDKVSgmsEMPGAFKTRKGMFRT 556

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  647 VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 726
Cdd:cd15896   557 VGQLYKEQLSKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILT 636

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 119586555  727 PAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd15896   637 PNAIPKG-FMDGKQACVLMIKSLELDPNLYRIGQSKVFFR 675
MYSc_Myh14_mammals cd14930
class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy ...
 100-766 0e+00

class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy chain 14 (also called FLJ13881, KIAA2034, MHC16, MYH17). Its members include mammals, chickens, and turtles. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276893 [Multi-domain]  Cd Length: 670  Bit Score: 673.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14930     2 SVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14930    82 SGAGKTENTKKVIQYLAHVASSPKGRKEPGVPGE--LERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGYIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYdYAFISQGETTVASiDDAEELMATDNAFDVL 339
Cdd:cd14930   160 GANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSH-YRFLTNGPSSSPG-QERELFQETLESLRVL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  340 GFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTeEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14930   238 GFSHEEITSMLRMVSAVLQFGNIVLKRERNTDQATmPDNT-AAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  419 QVIYATGALAKAVYERMFNWMVTRINATLEtKQPRQ--YFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14930   317 QADFALEALAKATYERLFRWLVLRLNRALD-RSPRQgaSFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVL 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNIKGkp 573
Cdd:cd14930   396 EQEEYQREGIPWTFLDFGLDLQPCIDLIERPAnppGLLALLDEECWFPKATDKSFVEKVAQEQ-GGHPKFQRPRHLRD-- 472

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  574 EAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAG----------ADAPiekgKGKAKKGSS 643
Cdd:cd14930   473 QADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGivgleqvsslGDGP----PGGRPRRGM 548

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  644 FQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 723
Cdd:cd14930   549 FRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYE 628

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|...
gi 119586555  724 ILNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14930   629 ILTPNAIPKG-FMDGKQACEKMIQALELDPNLYRVGQSKIFFR 670
MYSc_Myo1 cd01378
class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, ...
 100-766 0e+00

class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. There are 5 myosin subclasses with subclasses c/h, d/g, and a/b have an IQ domain and a TH1 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276829  Cd Length: 652  Bit Score: 664.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd01378     2 AINENLKKRFENDEIYTYIGHVLISVNPFKDLGIYTDEVLESYRGKNRYEVPPHVFALADSAYRNMKSEKENQCVIISGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIAaigdrskKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd01378    82 SGAGKTEASKRIMQYIAAVS-------GGSESEVERVKDMLLASNPLLEAFGNAKTLRNDNSSRFGKYMEIQFDFKGEPV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDVL 339
Cdd:cd01378   155 GGHITNYLLEKSRVVGQIKGERNFHIFYQLLKGASQEYLQELGLQRPEQYYYYSKSGCFDVDGIDDAADFKEVLNAMKVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  340 GFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDgTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEY---VTKGQN 416
Cdd:cd01378   235 GFTEEEQDSIFRILAAILHLGNIQFAEDEEGNAAISD-TSVLDFVAYLLGVDPDQLEKALTHRTIETGGGGrsvYEVPLN 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQ-YFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHhmFV 495
Cdd:cd01378   314 VEQAAYARDALAKAIYSRLFDWIVERINKSLAAKSGGKkKVIGVLDIYGFEIFEKNSFEQFCINYVNEKLQQIFIE--LT 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  496 L--EQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFP-KATDMTFKAKLfDNHLGKSANFQKPRNIKG 571
Cdd:cd01378   392 LkaEQEEYVREGIEWTPIKY-FNNKIICDLIEeKPPGIFAILDDACLTAgDATDQTFLQKL-NQLFSNHPHFECPSGHFE 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  572 KPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADA---PIekgkgkakkgssfqTVS 648
Cdd:cd01378   470 LRRGEFRIKHYAGDVTYNVEGFLDKNKDLLFKDLKELMQSSSNPFLRSLFPEGVDLDSkkrPP--------------TAG 535

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  649 ALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPA 728
Cdd:cd01378   536 TKFKNSANALVETLMKKQPSYIRCIKPNDNKSPGEFDEELVLHQVKYLGLLENVRVRRAGFAYRQTYEKFLERYKLLSPK 615

                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 119586555  729 AIPEGQFIDsRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01378   616 TWPAWDGTW-QGGVESILKDLNIPPEEYQMGKTKIFIR 652
MYSc_Myo8 cd01383
class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated ...
 99-766 0e+00

class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated with endocytosis, cytokinesis, cell-to-cell coupling and gating at plasmodesmata. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains IQ domains Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276834  Cd Length: 647  Bit Score: 650.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRgkKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd01383     1 PSVLHNLEYRYSQDIIYTKAGPVLIAVNPFKDVPLYGNEFITAYR--QKLLDSPHVYAVADTAYREMMRDEINQSIIISG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYfavIAAIGDrskkdqspGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd01383    79 ESGAGKTETAKIAMQY---LAALGG--------GSSGIENEILQTNPILEAFGNAKTLRNDNSSRFGKLIDIHFDAAGKI 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGET-TVASIDDAEELMATDNAFD 337
Cdd:cd01383   148 CGAKIQTYLLEKSRVVQLANGERSYHIFYQLCAGASPALREKLNLKS-ASEYKYLNQSNClTIDGVDDAKKFHELKEALD 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  338 VLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNV 417
Cdd:cd01383   227 TVGISKEDQEHIFQMLAAVLWLGNISFQVIDNENHVEVVADEAVSTAASLLGCNANDLMLALSTRKIQAGGDKIVKKLTL 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  418 QQVIYATGALAKAVYERMFNWMVTRINATLET-KQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd01383   307 QQAIDARDALAKAIYASLFDWLVEQINKSLEVgKRRTGRSISILDIYGFESFQKNSFEQLCINYANERLQQHFNRHLFKL 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  497 EQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLfDNHLGKSANFqkprniKGKPEA 575
Cdd:cd01383   387 EQEEYELDGIDWTKVDF-EDNQECLDLIEkKPLGLISLLDEESNFPKATDLTFANKL-KQHLKSNSCF------KGERGG 458

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  576 HFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENL 655
Cdd:cd01383   459 AFTIRHYAGEVTYDTSGFLEKNRDLLHSDLIQLLSSCSCQLPQLFASKMLDASRKALPLTKASGSDSQKQSVATKFKGQL 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  656 NKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 735
Cdd:cd01383   539 FKLMQRLENTTPHFIRCIKPNNKQLPGVFDQDLVLQQLRCCGVLEVVRISRSGYPTRMTHQEFARRYGFLLPEDVSASQD 618

                         650       660       670
                  ....*....|....*....|....*....|.
gi 119586555  736 IDSRKGAekLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01383   619 PLSTSVA--ILQQFNILPEMYQVGYTKLFFR 647
MYSc_Myo7 cd01381
class VII myosin, motor domain; These monomeric myosins have been associated with functions in ...
 100-766 0e+00

class VII myosin, motor domain; These monomeric myosins have been associated with functions in sensory systems such as vision and hearing. Mammalian myosin VII has a tail with 2 MyTH4 domains, 2 FERM domains, and a SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276832  Cd Length: 648  Bit Score: 640.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd01381     2 GILRNLLIRYREKLIYTYTGSILVAVNPYQILPIYTAEQIRLYRNKKIGELPPHIFAIADNAYTNMKRNKRDQCVVISGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIaaigdrskkdqSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd01381    82 SGAGKTESTKLILQYLAAI-----------SGQHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKNGVIE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITnNPYDYAFISQGETTVAS-IDDAEELMATDNAFDV 338
Cdd:cd01381   151 GAKIEQYLLEKSRIVSQAPDERNYHIFYCMLAGLSAEEKKKLELG-DASDYYYLTQGNCLTCEgRDDAAEFADIRSAMKV 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQRE--EQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd01381   230 LMFTDEEIWDIFKLLAAILHLGNIKFEATVVDnlDASEVRDPPNLERAAKLLEVPKQDLVDALTTRTIFTRGETVVSPLS 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYF---IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHM 493
Cdd:cd01381   310 AEQALDVRDAFVKGIYGRLFIWIVNKINSAIYKPRGTDSSrtsIGVLDIFGFENFEVNSFEQLCINFANENLQQFFVRHI 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  494 FVLEQEEYKKEGIEWTFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNikgK 572
Cdd:cd01381   390 FKLEQEEYDKEGINWQHIEF-VDNQDVLDLIaLKPMNIMSLIDEESKFPKGTDQTMLEKLHSTH-GNNKNYLKPKS---D 464

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  573 PEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApiekgkgkaKKGSSFQTVSALHR 652
Cdd:cd01381   465 LNTSFGINHFAGVVFYDTRGFLEKNRDTFSADLLQLVQSSKNKFLKQLFNEDISMGS---------ETRKKSPTLSSQFR 535

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  653 ENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPaAIPE 732
Cdd:cd01381   536 KSLDQLMKTLSACQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRKAGYPIRHTFEEFVERYRVLVP-GIPP 614

                         650       660       670
                  ....*....|....*....|....*....|....
gi 119586555  733 GQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01381   615 AHKTDCRAATRKICCAVLGGDADYQLGKTKIFLK 648
MYSc_Myo22 cd14883
class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ ...
 100-766 0e+00

class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ motifs such as found in class V, VIII, XI, and XIII myosins. These myosins are defined by two tandem MyTH4 and FERM domains. The apicomplexan, but not diatom myosins contain 4-6 WD40 repeats near the end of the C-terminal tail which suggests a possible function of these myosins in signal transduction and transcriptional regulation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276849 [Multi-domain]  Cd Length: 661  Bit Score: 619.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14883     2 GINTNLKVRYKKDLIYTYTGSILVAVNPYKELPIYTQDIVKQYFGKRMGALPPHIFALAEAAYTNMQEDGKNQSVIISGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYfavIAAIGDRSKKdqspgkgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14883    82 SGAGKTETTKLILQY---LCAVTNNHSW--------VEQQILEANTILEAFGNAKTVRNDNSSRFGKFIEVCFDASGHIK 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKK--PELLDmLLITNNPYDYAFISQ-GETTVASIDDAEELMATDNAF 336
Cdd:cd14883   151 GAIIQDYLLEQSRITFQAPGERNYHVFYQLLAGAKhsKELKE-KLKLGEPEDYHYLNQsGCIRIDNINDKKDFDHLRLAM 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
Cdd:cd14883   230 NVLGIPEEMQEGIFSVLSAILHLGNLTFEDIDGETGALtVEDKEILKIVAKLLGVDPDKLKKALTIRQINVRGNVTEIPL 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  416 NVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd14883   310 KVQEARDNRDAMAKALYSRTFAWLVNHINSCTNPGQKNSRFIGVLDIFGFENFKVNSFEQLCINYTNEKLHKFFNHYVFK 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  496 LEQEEYKKEGIEWTFIDFgMDLQACIDLIEK-PMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNIKGKPE 574
Cdd:cd14883   390 LEQEEYEKEGINWSHIVF-TDNQECLDLIEKpPLGILKLLDEECRFPKGTDLTYLEKLHAAH-EKHPYYEKPDRRRWKTE 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  575 ahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLF-----ANYAGADAPIEKGKGKAKKGSSFQTVSA 649
Cdd:cd14883   468 --FGVKHYAGEVTYTVQGFLDKNKDTQQDDLFDLMSRSKNKFVKELFtypdlLALTGLSISLGGDTTSRGTSKGKPTVGD 545

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  650 LHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAA 729
Cdd:cd14883   546 TFKHQLQSLVDVLSATQPWYVRCIKPNSLKEPNVFDDELVLAQLRYAGMLEIIRIRKEGFPIHLTFKEFVDRYLCLDPRA 625

                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 119586555  730 IPEGQfiDSRKGAEK-LLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14883   626 RSADH--KETCGAVRaLMGLGGLPEDEWQVGKTKVFLR 661
MYSc_Myo11 cd01384
class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle ...
 99-766 0e+00

class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle transport. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle.


Pssm-ID: 276835  Cd Length: 647  Bit Score: 585.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd01384     1 PGVLHNLKVRYELDEIYTYTGNILIAVNPFKRLPhLYDAHMMEQYKGAPLGELSPHVFAVADAAYRAMINEGKSQSILVS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  178 GESGAGKTVNTKRVIQYFAviaaigDRSKKDQSPGKgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257
Cdd:cd01384    81 GESGAGKTETTKMLMQYLA------YMGGRAVTEGR-SVEQQVLESNPLLEAFGNAKTVRNNNSSRFGKFVEIQFDDAGR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  258 LASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItNNPYDYAFISQGET-TVASIDDAEELMATDNAF 336
Cdd:cd01384   154 ISGAAIRTYLLERSRVVQVSDPERNYHCFYQLCAGAPPEDREKYKL-KDPKQFHYLNQSKCfELDGVDDAEEYRATRRAM 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKlKQREEQAEPDGTEEADKS----AYLMGLNSADLLKGLCHPRVKVGNEYVT 412
Cdd:cd01384   233 DVVGISEEEQDAIFRVVAAILHLGNIEFS-KGEEDDSSVPKDEKSEFHlkaaAELLMCDEKALEDALCKRVIVTPDGIIT 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  413 KGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHH 492
Cdd:cd01384   312 KPLDPDAATLSRDALAKTIYSRLFDWLVDKINRSIGQDPNSKRLIGVLDIYGFESFKTNSFEQFCINLANEKLQQHFNQH 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  493 MFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNhLGKSANFQKPRnikg 571
Cdd:cd01384   392 VFKMEQEEYTKEEIDWSYIEF-VDNQDVLDLIEkKPGGIIALLDEACMFPRSTHETFAQKLYQT-LKDHKRFSKPK---- 465

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  572 KPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFAnyagadapiEKGKGKAKKGSSFQTVSALH 651
Cdd:cd01384   466 LSRTDFTIDHYAGDVTYQTDLFLDKNKDYVVAEHQALLNASKCPFVAGLFP---------PLPREGTSSSSKFSSIGSRF 536

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  652 RENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIp 731
Cdd:cd01384   537 KQQLQELMETLNTTEPHYIRCIKPNNLLKPGIFENANVLQQLRCGGVLEAVRISCAGYPTRKPFEEFLDRFGLLAPEVL- 615

                         650       660       670
                  ....*....|....*....|....*....|....*
gi 119586555  732 eGQFIDSRKGAEKLLSSLDIdhNQYKFGHTKVFFK 766
Cdd:cd01384   616 -KGSDDEKAACKKILEKAGL--KGYQIGKTKVFLR 647
MYSc_Myo4 cd14872
class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or ...
 99-766 1.84e-174

class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or C-terminal to their motor domain and a tail with a MyTH4 domain followed by a SH3 domain in some instances. The monomeric Acanthamoebas were the first identified members of this group and have been joined by Stramenopiles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276839  Cd Length: 644  Bit Score: 545.14  E-value: 1.84e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14872     1 AMIVHNLRKRFKNDQIYTNVGTILISVNPFKRLPLYTPTVMDQYMHKGPKEMPPHTYNIADDAYRAMIVDAMNQSILISG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAigdrskkdqspGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14872    81 ESGAGKTEATKQCLSFFAEVAG-----------STNGVEQRVLLANPILEAFGNAKTLRNNNSSRFGKWVEIHFDNRGRI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLlitNNPYDYAFISQGET-TVASIDDAEELMATDNAFD 337
Cdd:cd14872   150 CGASTENYLLEKSRVVYQIKGERNFHIFYQLLASPDPASRGGW---GSSAAYGYLSLSGCiEVEGVDDVADFEEVVLAME 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  338 VLGFTSEEKNSMYKLTGAIMHFGNMKF------KLKQREEQAEPDGTEEAdksAYLMGLNSADLLKGLCHPRVKVgneyv 411
Cdd:cd14872   227 QLGFDDADINNVMSLIAAILKLGNIEFasgggkSLVSGSTVANRDVLKEV---ATLLGVDAATLEEALTSRLMEI----- 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  412 tKGQNV-------QQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNE 483
Cdd:cd14872   299 -KGCDPtripltpAQATDACDALAKAAYSRLFDWLVKKINESMRpQKGAKTTFIGVLDIFGFEIFEKNSFEQLCINFTNE 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  484 KLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEK-PMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSan 562
Cdd:cd14872   378 KLQQHFNQYTFKLEEALYQSEGVKFEHIDF-IDNQPVLDLIEKkQPGLMLALDDQVKIPKGSDATFMIAANQTHAAKS-- 454

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  563 FQKPRNIKGKPEaHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFanyagadAPIEkgkgkAKKGS 642
Cdd:cd14872   455 TFVYAEVRTSRT-EFIVKHYAGDVTYDITGFLEKNKDTLQKDLYVLLSSSKNKLIAVLF-------PPSE-----GDQKT 521

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  643 SFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRY 722
Cdd:cd14872   522 SKVTLGGQFRKQLSALMTALNATEPHYIRCVKPNQEKRARLFDGFMSLEQLRYAGVFEAVKIRKTGYPFRYSHERFLKRY 601

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 119586555  723 RILnPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14872   602 RFL-VKTIAKRVGPDDRQRCDLLLKSLKQDFSKVQVGKTRVLYR 644
MYSc_Myo42 cd14903
class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not ...
 99-766 2.32e-172

class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276868 [Multi-domain]  Cd Length: 658  Bit Score: 540.13  E-value: 2.32e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14903     1 AAILYNVKKRFLRKLPYTYTGDICIAVNPYQWLPeLYTEEQHSKYLNKPKEELPPHVYATSVAAYNHMKRSGRNQSILVS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  178 GESGAGKTVNTKRVIQYFAVIAaigdrskkdqspgkGTLED----QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFG 253
Cdd:cd14903    81 GESGAGKTETTKILMNHLATIA--------------GGLNDstikKIIEVNPLLESFGNAKTVRNDNSSRFGKFTQLQFD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  254 ATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDmLLITNNPYDYafisQGETTVASID---DAEELM 330
Cdd:cd14903   147 KNGTLVGAKCRTYLLEKTRVISHERPERNYHIFYQLLASPDVEERL-FLDSANECAY----TGANKTIKIEgmsDRKHFA 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  331 ATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE--PDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGN 408
Cdd:cd14903   222 RTKEALSLIGVSEEKQEVLFEVLAGILHLGQLQIQSKPNDDEKSaiAPGDQGAVYATKLLGLSPEALEKALCSRTMRAAG 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  409 EYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQF 488
Cdd:cd14903   302 DVYTVPLKKDQAEDCRDALAKAIYSNVFDWLVATINASLGNDAKMANHIGVLDIFGFEHFKHNSFEQFCINYANEKLQQK 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  489 FNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRN 568
Cdd:cd14903   382 FTQDVFKTVQIEYEEEGIRWAHIDF-ADNQDVLAVIEDRLGIISLLNDEVMRPKGNEESFVSKLSSIHKDEQDVIEFPRT 460

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  569 IKgkpeAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGS-----S 643
Cdd:cd14903   461 SR----TQFTIKHYAGPVTYESLGFLEKHKDALLPDLSDLMRGSSKPFLRMLFKEKVESPAAASTSLARGARRRrggalT 536

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  644 FQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 723
Cdd:cd14903   537 TTTVGTQFKDSLNELMTTIRSTNVHYVRCIKPNSIKSPTELDHLMVVSQLRCAGVIEAIRISRAAYPNRLLHEEFLDKFW 616

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 119586555  724 ILNPAAipEGQFIDSRKGAEKLLSSLDIDH-NQYKFGHTKVFFK 766
Cdd:cd14903   617 LFLPEG--RNTDVPVAERCEALMKKLKLESpEQYQMGLTRIYFQ 658
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 845-1924 3.73e-172

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 554.40  E-value: 3.73e-172
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNE 924
Cdd:pfam01576    3 QEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELES 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   925 RLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Cdd:pfam01576   83 RLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERIS 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1005 QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKD 1084
Cdd:pfam01576  163 EFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKE 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1085 FELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164
Cdd:pfam01576  243 EELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELR 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKaA 1244
Cdd:pfam01576  323 SKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAK-Q 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1245 NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEV 1324
Cdd:pfam01576  402 DSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEET 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1325 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQEAEEA 1404
Cdd:pfam01576  482 RQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQ 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1405 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFK 1484
Cdd:pfam01576  561 LEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALS 640

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1485 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1564
Cdd:pfam01576  641 LARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEV 720

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1565 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV 1644
Cdd:pfam01576  721 NMQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQL 800

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1645 KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1724
Cdd:pfam01576  801 KKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSAL 880

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1725 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1804
Cdd:pfam01576  881 QDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGT 960

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1805 ALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAE 1884
Cdd:pfam01576  961 VKSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLE 1040

                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|
gi 119586555  1885 EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1924
Cdd:pfam01576 1041 EAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
MYSc_Myo6 cd01382
class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the ...
 102-766 9.26e-170

class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins which moves towards the plus-end of actin filaments. It is thought that myosin VI, unlike plus-end directed myosins, does not use a pure lever arm mechanism, but instead steps with a mechanism analogous to the kinesin neck-linker uncoupling model. It has been implicated in a myriad of functions including: the transport of cytoplasmic organelles, maintenance of normal Golgi morphology, endocytosis, secretion, cell migration, border cell migration during development, and in cancer metastasis playing roles in deafness and retinal development among others. While how this is accomplished is largely unknown there are several interacting proteins that have been identified such as disabled homolog 2 (DAB2), GIPC1, synapse-associated protein 97 (SAP97; also known as DLG1) and optineurin, which have been found to target myosin VI to different cellular compartments. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the minus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276833  Cd Length: 649  Bit Score: 532.59  E-value: 9.26e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  102 LYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd01382     4 LNNIRVRYSKDKIYTYVANILIAVNPYFDIPkLYSSETIKSYQGKSLGTLPPHVFAIADKAYRDMKVLKQSQSIIVSGES 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  181 GAGKTVNTKRVIQYFAVIAAIGDrskkdqspgkGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLAS 260
Cdd:cd01382    84 GAGKTESTKYILRYLTESWGSGA----------GPIEQRILEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  261 ADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLitnnpydyafisqgetTVASIDDAEELMATDNAFDVLG 340
Cdd:cd01382   154 GFVSHYLLEKSRICVQSKEERNYHIFYRLCAGAPEDLREKLL----------------KDPLLDDVGDFIRMDKAMKKIG 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  341 FTSEEKNSMYKLTGAIMHFGNMKFklkqrEEQAEPDG-----TEEADKS----AYLMGLNSADLLKGLCHpRVKVGNEYV 411
Cdd:cd01382   218 LSDEEKLDIFRVVAAVLHLGNIEF-----EENGSDSGggcnvKPKSEQSleyaAELLGLDQDELRVSLTT-RVMQTTRGG 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  412 TKGQ------NVQQVIYATGALAKAVYERMFNWMVTRINATLETKQpRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKL 485
Cdd:cd01382   292 AKGTvikvplKVEEANNARDALAKAIYSKLFDHIVNRINQCIPFET-SSYFIGVLDIAGFEYFEVNSFEQFCINYCNEKL 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  486 QQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNHLgKSANFQ 564
Cdd:cd01382   371 QQFFNERILKEEQELYEKEGLGVKEVEY-VDNQDCIDLIEaKLVGILDLLDEESKLPKPSDQHFTSAVHQKHK-NHFRLS 448

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  565 KPRniKGKPEAH--------FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApiekGKG 636
Cdd:cd01382   449 IPR--KSKLKIHrnlrddegFLIRHFAGAVCYETAQFIEKNNDALHASLESLICESKDKFIRSLFESSTNNNK----DSK 522

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  637 KAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 716
Cdd:cd01382   523 QKAGKLSFISVGNKFKTQLNLLMDKLRSTGTSFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRTSFH 602

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|
gi 119586555  717 DFRQRYRILNPAAIPEgqfIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01382   603 DLYNMYKKYLPPKLAR---LDPRLFCKALFKALGLNENDFKFGLTKVFFR 649
MYSc_Myo15 cd01387
class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, ...
 100-766 3.90e-168

class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, myosin XV appears to be expressed in sensory tissue and play a role in hearing. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are 2 MyTH4 domain, a FERM domain, and a SH3 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276838 [Multi-domain]  Cd Length: 657  Bit Score: 528.55  E-value: 3.90e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd01387     2 TVLWNLKTRYERNLIYTYIGSILVSVNPYKMFDIYGLEQVQQYSGRALGELPPHLFAIANLAFAKMLDAKQNQCVVISGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIAaigdrskkdQSPGKGTLEdQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgATGKLA 259
Cdd:cd01387    82 SGSGKTEATKLIMQYLAAVN---------QRRNNLVTE-QILEATPLLEAFGNAKTVRNDNSSRFGKYLEVFF-EGGVIV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDM--LLitnNPYDYAFISQGETT-VASIDDAEELMATDNAF 336
Cdd:cd01387   151 GAITSQYLLEKSRIVTQAKNERNYHVFYELLAGLPAQLRQKygLQ---EAEKYFYLNQGGNCeIAGKSDADDFRRLLAAM 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQRE---EQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTK 413
Cdd:cd01387   228 QVLGFSSEEQDSIFRILASVLHLGNVYFHKRQLRhgqEGVSVGSDAEIQWVAHLLQISPEGLQKALTFKVTETRRERIFT 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  414 GQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHM 493
Cdd:cd01387   308 PLTIDQALDARDAIAKALYALLFSWLVTRVNAIVYSGTQDTLSIAILDIFGFEDLSENSFEQLCINYANENLQYYFNKHV 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  494 FVLEQEEYKKEGIEWTFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRniKGK 572
Cdd:cd01387   388 FKLEQEEYIREQIDWTEIAF-ADNQPVINLIsKKPVGILHILDDECNFPQATDHSFLEKCHYHH-ALNELYSKPR--MPL 463

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  573 PEahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYagadAPIEKGKGKAKKGSSF-------Q 645
Cdd:cd01387   464 PE--FTIKHYAGQVWYQVHGFLDKNRDQLRQDVLELLVSSRTRVVAHLFSSH----RAQTDKAPPRLGKGRFvtmkprtP 537

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  646 TVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL 725
Cdd:cd01387   538 TVAARFQDSLLQLLEKMERCNPWFVRCLKPNHKKEPMLFDMDVVMAQLRYSGMLETIRIRKEGYPVRLPFQVFIDRYRCL 617

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|...
gi 119586555  726 NPAAIPEGQFIDSRkgaEKLLSSLD--IDHNQYKFGHTKVFFK 766
Cdd:cd01387   618 VALKLPRPAPGDMC---VSLLSRLCtvTPKDMYRLGATKVFLR 657
MYSc_Myo29 cd14890
class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have ...
 100-766 3.51e-167

class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have very long tail domains consisting of three IQ motifs, short coiled-coil regions, up to 18 CBS domains, a PB1 domain, and a carboxy-terminal transmembrane domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276855 [Multi-domain]  Cd Length: 662  Bit Score: 526.27  E-value: 3.51e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYML----TDRENQSI 174
Cdd:cd14890     2 SLLHTLRLRYERDEIYTYVGPILISINPYKSIPdLYSEERMLLYHGTTAGELPPHVFAIADHAYTQLIqsgvLDPSNQSI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  175 LITGESGAGKTVNTKRVIQY-------FAVIAAIGDRSKKDQSPGK-GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGK 246
Cdd:cd14890    82 IISGESGAGKTEATKIIMQYlaritsgFAQGASGEGEAASEAIEQTlGSLEDRVLSSNPLLESFGNAKTLRNDNSSRFGK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  247 FIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGETTVASIDDA 326
Cdd:cd14890   162 FIEIQFDHHGKIVGAEISNFLLEKTRIVTQNDGERNYHIFYQLLAGADEALRERLKLQT-PVEYFYLRGECSSIPSCDDA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  327 EELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEA-DKSAYLMGLNSADLLKGLCHPRVK 405
Cdd:cd14890   241 KAFAETIRCLSTIGISEENQDAVFGLLAAVLHLGNVDFESENDTTVLEDATTLQSlKLAAELLGVNEDALEKALLTRQLF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  406 VGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKL 485
Cdd:cd14890   321 VGGKTIVQPQNVEQARDKRDALAKALYSSLFLWLVSELNRTISSPDDKWGFIGVLDIYGFEKFEWNTFEQLCINYANEKL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  486 QQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILE--EEC--MFPKATDMTFKAKLFDNHLGKS 560
Cdd:cd14890   401 QRHFNQHMFEVEQVEYSNEGIDWQYITF-NDNQACLELIEgKVNGKPGIFItlDDCwrFKGEEANKKFVSQLHASFGRKS 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  561 ANFQKPRNIKGKP---------EAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTlfanyagadapi 631
Cdd:cd14890   480 GSGGTRRGSSQHPhfvhpkfdaDKQFGIKHYAGDVIYDASGFNEKNNETLNAEMKELIKQSRRSIREV------------ 547

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  632 ekgkgkakkgssfqTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPN 711
Cdd:cd14890   548 --------------SVGAQFRTQLQELMAKISLTNPRYVRCIKPNETKAPGKFDGLDCLRQLKYSGMMEAIQIRQQGFAL 613

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555  712 RILYGDFRQRYRILNPAAipegqfiDSRKGAEKLLSS-LDIDHNQYKFGHTKVFFK 766
Cdd:cd14890   614 REEHDSFFYDFQVLLPTA-------ENIEQLVAVLSKmLGLGKADWQIGSSKIFLK 662
MYSc_Myo3 cd01379
class III myosin, motor domain; Myosin III has been shown to play a role in the vision process ...
 99-766 1.33e-165

class III myosin, motor domain; Myosin III has been shown to play a role in the vision process in insects and in hearing in mammals. Myosin III, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They are characterized by an N-terminal protein kinase domain and several IQ domains. Some members also contain WW, SH2, PH, and Y-phosphatase domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276830 [Multi-domain]  Cd Length: 633  Bit Score: 520.68  E-value: 1.33e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd01379     1 DTIVSQLQKRYSRDQIYTYIGDILIAVNPFQNLGIYTEEHSRLYRGAKRSDNPPHIFAVADAAYQAMIHQKKNQCIVISG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRskkdqspgkgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd01379    81 ESGAGKTESANLLVQQLTVLGKANNR----------TLEEKILQVNPLMEAFGNARTVINDNSSRFGKYLEMKFTSTGAV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQIL----SNKKpeLLDMLLITNNPYDY-AFISQGETTVASID-DAEELMAT 332
Cdd:cd01379   151 TGARISEYLLEKSRVVHQAIGERNFHIFYYIYaglaEDKK--LAKYKLPENKPPRYlQNDGLTVQDIVNNSgNREKFEEI 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  333 DNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQ----AEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGN 408
Cdd:cd01379   229 EQCFKVIGFTKEEVDSVYSILAAILHIGDIEFTEVESNHQtdksSRISNPEALNNVAKLLGIEADELQEALTSHSVVTRG 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  409 EYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL---ETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKL 485
Cdd:cd01379   309 ETIIRNNTVEEATDARDAMAKALYGRLFSWIVNRINSLLkpdRSASDEPLSIGILDIFGFENFQKNSFEQLCINIANEQI 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  486 QQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACID-LIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHlgKSANFQ 564
Cdd:cd01379   389 QYYFNQHIFAWEQQEYLNEGIDVDLIEYE-DNRPLLDmFLQKPMGLLALLDEESRFPKATDQTLVEKFHNNI--KSKYYW 465

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  565 KPRnikgKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLStlfanyagadapiekgkgkakkgssf 644
Cdd:cd01379   466 RPK----SNALSFGIHHYAGKVLYDASGFLEKNRDTLPPDVVQLLRSSENPLVR-------------------------- 515

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  645 QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 724
Cdd:cd01379   516 QTVATYFRYSLMDLLSKMVVGQPHFVRCIKPNDSRQAGKFDREKVLKQLRYTGVLETTRIRRQGFSHRILFADFLKRYYF 595

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 119586555  725 L--NPAAIPEGqfidSRKGAEKLLSSLDIDHnqYKFGHTKVFFK 766
Cdd:cd01379   596 LafKWNEEVVA----NRENCRLILERLKLDN--WALGKTKVFLK 633
MYSc_Myo27 cd14888
class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic ...
 99-766 6.60e-165

class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276853 [Multi-domain]  Cd Length: 667  Bit Score: 520.02  E-value: 6.60e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRgKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14888     1 ASILHSLNLRFDIDEIYTFTGPILIAVNPFKTIPgLYSDEMLLKFI-QPSISKSPHVFSTASSAYQGMCNNKKSQTILIS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  178 GESGAGKTVNTKRVIQYFAViAAIGDRSKKDqspgkgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF----- 252
Cdd:cd14888    80 GESGAGKTESTKYVMKFLAC-AGSEDIKKRS------LVEAQVLESNPLLEAFGNARTLRNDNSSRFGKFIELQFsklks 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  253 ----GATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILS-----------------------NKKPELLDMLLI-T 304
Cdd:cd14888   153 krmsGDRGRLCGAKIQTYLLEKVRVCDQQEGERNYHIFYQLCAaareakntglsyeendeklakgaDAKPISIDMSSFeP 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  305 NNPYDYAFISqGETTVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQA---EPDGTEEA 381
Cdd:cd14888   233 HLKFRYLTKS-SCHELPDVDDLEEFESTLYAMQTVGISPEEQNQIFSIVAAILYLGNILFENNEACSEGavvSASCTDDL 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  382 DKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVL 460
Cdd:cd14888   312 EKVASLLGVDAEDLLNALCYRTIKTAHEFYTKPLRVDEAEDVRDALARALYSCLFDKVVERTNESIGySKDNSLLFCGVL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  461 DIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLI-EKPMGIMSILEEECM 539
Cdd:cd14888   392 DIFGFECFQLNSFEQLCINFTNERLQQFFNNFVFKCEEKLYIEEGISWNPLDFP-DNQDCVDLLqEKPLGIFCMLDEECF 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  540 FPKATDMTFKAKLFDNHLGKSaNFQKprnIKGKPEAhFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLST 619
Cdd:cd14888   471 VPGGKDQGLCNKLCQKHKGHK-RFDV---VKTDPNS-FVIVHFAGPVKYCSDGFLEKNKDQLSVDAQEVIKNSKNPFISN 545

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  620 LFANYagadapIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVL 699
Cdd:cd14888   546 LFSAY------LRRGTDGNTKKKKFVTVSSEFRNQLDVLMETIDKTEPHFIRCIKPNSQNVPDLFDRISVNEQLKYGGVL 619

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555  700 EGIRICRKGFPNRILYGDFRQRYRILNPaaiPEGQfidsrkgaekllssldIDHNQYKFGHTKVFFK 766
Cdd:cd14888   620 QAVQVSRAGYPVRLSHAEFYNDYRILLN---GEGK----------------KQLSIWAVGKTLCFFK 667
MYSc_Myo40 cd14901
class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much ...
 99-764 7.80e-160

class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276866 [Multi-domain]  Cd Length: 655  Bit Score: 505.86  E-value: 7.80e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAY------RGKKRSEAPPHIFSISDNAYQYMLTDRE-- 170
Cdd:cd14901     1 PSILHVLRRRFAHGLIYTSTGAILVAINPFRRLPLYDDETKEAYyehgerRAAGERKLPPHVYAVADKAFRAMLFASRgq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  171 --NQSILITGESGAGKTVNTKRVIQYfavIAAIGDRSKKDQSPG-KGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKF 247
Cdd:cd14901    81 kcDQSILVSGESGAGKTETTKIIMNY---LASVSSATTHGQNATeRENVRDRVLESNPILEAFGNARTNRNNNSSRFGKF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  248 IRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPyDYAFISQGETTVA--SIDD 325
Cdd:cd14901   158 IRLGFASSGSLLGASISTYLLERVRLVSQAKGERNYHIFYELLRGASSDELHALGLTHVE-EYKYLNSSQCYDRrdGVDD 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  326 AEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAY-LMGLNSADLLKGLCHPRV 404
Cdd:cd14901   237 SVQYAKTRHAMTTIGMSPDEQISVLQLVAAVLHLGNLCFVKKDGEGGTFSMSSLANVRAACdLLGLDMDVLEKTLCTREI 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  405 KVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQP--RQYFIGVLDIAGFEIFDFNSFEQLCINFTN 482
Cdd:cd14901   317 RAGGEYITMPLSVEQALLTRDVVAKTLYAQLFDWLVDRINESIAYSEStgASRFIGIVDIFGFEIFATNSLEQLCINFAN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  483 EKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDlQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNhLGKSA 561
Cdd:cd14901   397 EKLQQLFGKFVFEMEQDEYVAEAIPWTFVEYPNN-DACVAMFEaRPTGLFSLLDEQCLLPRGNDEKLANKYYDL-LAKHA 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  562 NFQKPRNIKGKpeAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTlfanyagadapiekgkgkakkg 641
Cdd:cd14901   475 SFSVSKLQQGK--RQFVIHHYAGAVCYATDGFCDKNKDHVHSEALALLRTSSNAFLSS---------------------- 530

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  642 ssfqTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 721
Cdd:cd14901   531 ----TVVAKFKVQLSSLLEVLNATEPHFIRCIKPNDVLSPSEFDAKRVLEQLRCSGVLEAVKISRSGYPVRFPHDAFVHT 606

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 119586555  722 YRILNPAAIPEGQFIdsRKGAEKLLSSLDI------DHNQYKFGHTKVF 764
Cdd:cd14901   607 YSCLAPDGASDTWKV--NELAERLMSQLQHselnieHLPPFQVGKTKVF 653
MYSc_Myo9 cd01385
class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play ...
 102-766 2.03e-158

class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play a role in signalling. It has a N-terminal RA domain, an IQ domain, a C1_1 domain, and a RhoGAP domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276836 [Multi-domain]  Cd Length: 690  Bit Score: 503.45  E-value: 2.03e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  102 LYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESG 181
Cdd:cd01385     4 LENLRARFKHGKIYTYVGSILIAVNPFKFLPIYNPKYVKMYQNRRLGKLPPHIFAIADVAYHAMLRKKKNQCIVISGESG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  182 AGKTVNTKRVIQYFAVIaaigdrSKKDQSPGkgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASA 261
Cdd:cd01385    84 SGKTESTNFLLHHLTAL------SQKGYGSG---VEQTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYRENGMVRGA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  262 DIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGET-TVASIDDAEELMATDNAFDVLG 340
Cdd:cd01385   155 VVEKYLLEKSRIVSQEKNERNYHVFYYLLAGASEEERKELHLKQ-PEDYHYLNQSDCyTLEGEDEKYEFERLKQAMEMVG 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  341 FTSEEKNSMYKLTGAIMHFGNMKFKLK--QREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd01385   234 FLPETQRQIFSVLSAVLHLGNIEYKKKayHRDESVTVGNPEVLDIISELLRVKEETLLEALTTKKTVTVGETLILPYKLP 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQ----PRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 494
Cdd:cd01385   314 EAIATRDAMAKCLYSALFDWIVLRINHALLNKKdleeAKGLSIGVLDIFGFEDFGNNSFEQFCINYANEHLQYYFNQHIF 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  495 VLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKlFDNHLGKSANFQKPRnikgKP 573
Cdd:cd01385   394 KLEQEEYKKEGISWHNIEY-TDNTGCLQLISkKPTGLLCLLDEESNFPGATNQTLLAK-FKQQHKDNKYYEKPQ----VM 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  574 EAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLF------------------ANYAGADA------ 629
Cdd:cd01385   468 EPAFIIAHYAGKVKYQIKDFREKNLDLMRPDIVAVLRSSSSAFVRELIgidpvavfrwavlraffrAMAAFREAgrrraq 547

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  630 -----------PIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGV 698
Cdd:cd01385   548 rtaghsltlhdRTTKSLLHLHKKKKPPSVSAQFQTSLSKLMETLGQAEPFFIRCIKSNAEKKPLRFDDELVLRQLRYTGM 627

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119586555  699 LEGIRICRKGFPNRILYGDFRQRYRILnpaaIPEGQfIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01385   628 LETVRIRRSGYSVRYTFQEFITQFQVL----LPKGL-ISSKEDIKDFLEKLNLDRDNYQIGKTKVFLK 690
MYSc_Myo31 cd14892
class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of ...
 105-766 2.18e-152

class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of 17 IQ motifs and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276857 [Multi-domain]  Cd Length: 656  Bit Score: 485.42  E-value: 2.18e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  105 LKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRG--KKRSEAPPHIFSISDNAYQYMLTDR----ENQSILIT 177
Cdd:cd14892     7 LRRRYERDAIYTFTADILISINPYKSIPlLYDVPGFDSQRKeeATASSPPPHVFSIAERAYRAMKGVGkgqgTPQSIVVS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  178 GESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKG--TLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT 255
Cdd:cd14892    87 GESGAGKTEASKYIMKYLATASKLAKGASTSKGAANAheSIEECVLLSNLILEAFGNAKTIRNDNSSRFGKYIQIHYNSD 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  256 GKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKpELLDMLLITNNPYDYAFISQGE-TTVASIDDAEELMATDN 334
Cdd:cd14892   167 GRIAGASTDHFLLEKSRLVGPDANERNYHIFYQLLAGLD-ANENAALELTPAESFLFLNQGNcVEVDGVDDATEFKQLRD 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  335 AFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKL--KQREEQAEPDGTEEADKSAYLMGLNSADLLKGLChPRVKVGneyvT 412
Cdd:cd14892   246 AMEQLGFDAEFQRPIFEVLAAVLHLGNVRFEEnaDDEDVFAQSADGVNVAKAAGLLGVDAAELMFKLV-TQTTST----A 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  413 KGQNVQ------QVIYATGALAKAVYERMFNWMVTRINAtlETKQ------------PRQYFIGVLDIAGFEIFDFNSFE 474
Cdd:cd14892   321 RGSVLEikltarEAKNALDALCKYLYGELFDWLISRINA--CHKQqtsgvtggaaspTFSPFIGILDIFGFEIMPTNSFE 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  475 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEK-PMGIMSILEEECMFP-KATDMTFKAKL 552
Cdd:cd14892   399 QLCINFTNEMLQQQFNKHVFVLEQEVYASEGIDVSAIEF-QDNQDCLDLIQKkPLGLLPLLEEQMLLKrKTTDKQLLTIY 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  553 FDNHLGKSANFQKPRNikgkPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSslkllstlfanyagadapie 632
Cdd:cd14892   478 HQTHLDKHPHYAKPRF----ECDEFVLRHYAGDVTYDVHGFLAKNNDNLHDDLRDLLRSS-------------------- 533

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  633 kgkgkakkgSSFqtvsalhRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNR 712
Cdd:cd14892   534 ---------SKF-------RTQLAELMEVLWSTTPSYIKCIKPNNLKFPGGFSCELVRDQLIYSGVLEVVRIRREGFPIR 597

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555  713 ILYGDFRQRYRIL-----NPAAIPEGQ--FIDSRKGAEKLLSSLdiDHNQYKFGHTKVFFK 766
Cdd:cd14892   598 RQFEEFYEKFWPLarnkaGVAASPDACdaTTARKKCEEIVARAL--ERENFQLGRTKVFLR 656
MYSc_Myo10 cd14873
class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a ...
 100-766 2.29e-151

class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a monomer. In mammalian cells, the motor is found to localize to filopodia. Myosin X walks towards the barbed ends of filaments and is thought to walk on bundles of actin, rather than single filaments, a unique behavior. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are a variable number of IQ domains, 2 PH domains, a MyTH4 domain, and a FERM domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276840 [Multi-domain]  Cd Length: 651  Bit Score: 482.76  E-value: 2.29e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14873     2 SIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAgLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIA--AIGDRSKKDQSpgkgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14873    82 ESGAGKTESTKLILKFLSVISqqSLELSLKEKTS----CVEQAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITnNPYDYAFISQ-GETTVASIDDAEELMATDNA 335
Cdd:cd14873   158 NIQGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREEFYLS-TPENYHYLNQsGCVEDKTISDQESFREVITA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  336 FDVLGFTSEEKNSMYKLTGAIMHFGNMKFklkqreeqAEPDGTEEADK-----SAYLMGLNSADLLKGLCHPRVKVGNEY 410
Cdd:cd14873   237 MEVMQFSKEEVREVSRLLAGILHLGNIEF--------ITAGGAQVSFKtalgrSAELLGLDPTQLTDALTQRSMFLRGEE 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  411 VTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQyFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFN 490
Cdd:cd14873   309 ILTPLNVQQAVDSRDSLAMALYARCFEWVIKKINSRIKGKEDFK-SIGILDIFGFENFEVNHFEQFNINYANEKLQEYFN 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  491 HHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRnik 570
Cdd:cd14873   388 KHIFSLEQLEYSREGLVWEDIDW-IDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHSQH-ANNHFYVKPR--- 462

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  571 gKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApieKGKGKAKKGSSFQTVSAL 650
Cdd:cd14873   463 -VAVNNFGVKHYAGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNN---QDTLKCGSKHRRPTVSSQ 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  651 HRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNP-AA 729
Cdd:cd14873   539 FKDSLHSLMATLSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRnLA 618

                         650       660       670
                  ....*....|....*....|....*....|....*..
gi 119586555  730 IPEgqfiDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14873   619 LPE----DVRGKCTSLLQLYDASNSEWQLGKTKVFLR 651
MYSc_Myo36 cd14897
class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain ...
 101-766 2.37e-148

class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain followed by a GlcAT-I (Beta1,3-glucuronyltransferase I) domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276862 [Multi-domain]  Cd Length: 635  Bit Score: 473.79  E-value: 2.37e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKK-RSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14897     3 IVQTLKSRYNKDKFYTYIGDILVAVNPCKPLPIFDKKHHEEYSNLSvRSQRPPHLFWIADQAYRRLLETGRNQCILVSGE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAVIaaigdrSKKDQSpgkgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14897    83 SGAGKTESTKYMIKHLMKL------SPSDDS----DLLDKIVQINPLLEAFGNASTVMNDNSSRFGKFIELHFTENGQLL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItNNPYDYAFISQGETTVASIDDAEELMATDNAFDVL 339
Cdd:cd14897   153 GAKIDDYLLEKSRVVHRGNGEKNFHIFYALFAGMSRDRLLYYFL-EDPDCHRILRDDNRNRPVFNDSEELEYYRQMFHDL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  340 -------GFTSEEKNSMYKLTGAIMHFGNMKFklkqrEEQAEPDGTEEADK-----SAYLMGLNSADLLKGLCHPRVKVG 407
Cdd:cd14897   232 tnimkliGFSEEDISVIFTILAAILHLTNIVF-----IPDEDTDGVTVADEyplhaVAKLLGIDEVELTEALISNVNTIR 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  408 NEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYF-----IGVLDIAGFEIFDFNSFEQLCINFTN 482
Cdd:cd14897   307 GERIQSWKSLRQANDSRDALAKDLYSRLFGWIVGQINRNLWPDKDFQIMtrgpsIGILDMSGFENFKINSFDQLCINLSN 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  483 EKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLfDNHLGKSA 561
Cdd:cd14897   387 ERLQQYFNDYVFPRERSEYEIEGIEWRDIEY-HDNDDVLELFfKKPLGILPLLDEESTFPQSTDSSLVQKL-NKYCGESP 464

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  562 NFQKPrnIKGKPEahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYagadapiekgkgkakkg 641
Cdd:cd14897   465 RYVAS--PGNRVA--FGIRHYAEQVTYDADGFLEKNRDNLSSDIVGCLLNSNNEFISDLFTSY----------------- 523

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  642 ssfqtvsalHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 721
Cdd:cd14897   524 ---------FKRSLSDLMTKLNSADPLFVRCIKPNNFLRPNKFDDELVRRQLLCNGLMEIAKIRRDGYPIRIKYEDFVKR 594

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*..
gi 119586555  722 YRILNPAAIPegqfidSRKGAE-KLLSSLDIDHNQ-YKFGHTKVFFK 766
Cdd:cd14897   595 YKEICDFSNK------VRSDDLgKCQKILKTAGIKgYQFGKTKVFLK 635
MYSc_Myo43 cd14904
class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not ...
 99-766 1.12e-143

class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276869  Cd Length: 653  Bit Score: 461.33  E-value: 1.12e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14904     1 PSILFNLKKRFAASKPYTYTNDIVIALNPYKWIDnLYGDHLHEQYLKKPRDKLQPHVYATSTAAYKHMLTNEMNQSILVS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  178 GESGAGKTVNTKRVIQYFAVIAAigdrSKKDQSPGKgtledqIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257
Cdd:cd14904    81 GESGAGKTETTKIVMNHLASVAG----GRKDKTIAK------VIDVNPLLESFGNAKTTRNDNSSRFGKFTQLQFDGRGK 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  258 LASADIETYLLEKSRVIFQLKAERDYHIFYQILSN-KKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14904   151 LIGAKCETYLLEKSRVVSIAEGERNYHIFYQLLAGlSSEERKEFGLDPNCQYQYLGDSLAQMQIPGLDDAKLFASTQKSL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFkLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd14904   231 SLIGLDNDAQRTLFKILSGVLHLGEVMF-DKSDENGSRISNGSQLSQVAKMLGLPTTRIEEALCNRSVVTRNESVTVPLA 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQY-FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd14904   310 PVEAEENRDALAKAIYSKLFDWMVVKINAAISTDDDRIKgQIGVLDIFGFEDFAHNGFEQFCINYANEKLQQKFTTDVFK 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  496 LEQEEYKKEGIEWTFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNH--LGKSANFQKPRNIKgkp 573
Cdd:cd14904   390 TVEEEYIREGLQWDHIEY-QDNQGIVEVIDGKMGIIALMNDHLRQPRGTEEALVNKIRTNHqtKKDNESIDFPKVKR--- 465

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  574 eAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANyagADAPIEKGKGKA-KKGSSFQTVSALHR 652
Cdd:cd14904   466 -TQFIINHYAGPVTYETVGFMEKHRDTLQNDLLDLVLLSSLDLLTELFGS---SEAPSETKEGKSgKGTKAPKSLGSQFK 541

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  653 ENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPE 732
Cdd:cd14904   542 TSLSQLMDNIKTTNTHYVRCIKPNANKSPTEFDKRMVVEQLRSAGVIEAIRITRSGYPSRLTPKELATRYAIMFPPSMHS 621

                         650       660       670
                  ....*....|....*....|....*....|....*
gi 119586555  733 GqfiDSRKGAEKLLSSLDIDHN-QYKFGHTKVFFK 766
Cdd:cd14904   622 K---DVRRTCSVFMTAIGRKSPlEYQIGKSLIYFK 653
MYSc_Myo39 cd14900
class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much ...
 101-731 1.78e-141

class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276865  Cd Length: 627  Bit Score: 454.38  E-value: 1.78e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAY-----------RGKKRSEAPPHIFSISDNAYQYM--- 165
Cdd:cd14900     3 ILSALETRFYAQKIYTNTGAILLAVNPFQKLPgLYSSDTMAKYllsfearssstRNKGSDPMPPHIYQVAGEAYKAMmlg 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  166 -LTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRF 244
Cdd:cd14900    83 lNGVMSDQSILVSGESGSGKTESTKFLMEYLAQAGDNNLAASVSMGKSTSGIAAKVLQTNILLESFGNARTLRNDNSSRF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  245 GKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLdmllitnnpydyafisqgettvaSID 324
Cdd:cd14900   163 GKFIKLHFTSGGRLTGASIQTYLLEKVRLVSQSKGERNYHIFYEMAIGASEAAR-----------------------KRD 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  325 DAEELMAtdnAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFK-------LKQREEQAEPDGTEEADKSAYLMGLNSADLLK 397
Cdd:cd14900   220 MYRRVMD---AMDIIGFTPHERAGIFDLLAALLHIGNLTFEhdensdrLGQLKSDLAPSSIWSRDAAATLLSVDATKLEK 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  398 GLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL-----ETKQPRQYFIGVLDIAGFEIFDFNS 472
Cdd:cd14900   297 ALSVRRIRAGTDFVSMKLSAAQANNARDALAKALYGRLFDWLVGKMNAFLkmddsSKSHGGLHFIGILDIFGFEVFPKNS 376

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  473 FEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAK 551
Cdd:cd14900   377 FEQLCINFANETLQQQFNDYVFKAEQREYESQGVDWKYVEF-CDNQDCVNLIsQRPTGILSLIDEECVMPKGSDTTLASK 455

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  552 LFdNHLGKSANFQKPRNIKGKpeAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQksslkllstlfanYAGAdapi 631
Cdd:cd14900   456 LY-RACGSHPRFSASRIQRAR--GLFTIVHYAGHVEYSTDGFLEKNKDVLHQEAVDLFV-------------YGLQ---- 515

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  632 ekgkgkakkgssfqtvsalHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPN 711
Cdd:cd14900   516 -------------------FKEQLTTLLETLQQTNPHYVRCLKPNDLCKAGIYERERVLNQLRCNGVMEAVRVARAGFPI 576

                         650       660
                  ....*....|....*....|
gi 119586555  712 RILYGDFRQRYRILNPAAIP 731
Cdd:cd14900   577 RLLHDEFVARYFSLARAKNR 596
MYSc_Myo28 cd14889
class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The ...
 101-766 1.28e-140

class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The tail regions of these class-XXVIII myosins consist of an IQ motif, a short coiled-coil region, and an SH2 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276854  Cd Length: 659  Bit Score: 453.21  E-value: 1.28e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYML----TDRENQSILI 176
Cdd:cd14889     3 LLEVLKVRFMQSNIYTYVGDILVAINPFKYLHIYEKEVSQKYKCEKKSSLPPHIFAVADRAYQSMLgrlaRGPKNQCIVI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  177 TGESGAGKTVNTKRVIqyfaviaaigdRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgATG 256
Cdd:cd14889    83 SGESGAGKTESTKLLL-----------RQIMELCRGNSQLEQQILQVNPLLEAFGNAQTVMNDNSSRFGKYIQLRF-RNG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQI---LSNKKPELLDMLlitnNPYDYAFISQG---ETTVASIDDA-EEL 329
Cdd:cd14889   151 HVKGAKINEYLLEKSRVVHQDGGEENFHIFYYMfagISAEDRENYGLL----DPGKYRYLNNGagcKREVQYWKKKyDEV 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  330 MatdNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREE-QAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGN 408
Cdd:cd14889   227 C---NAMDMVGFTEQEEVDMFTILAGILSLGNITFEMDDDEAlKVENDSNGWLKAAAGQFGVSEEDLLKTLTCTVTFTRG 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  409 EYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQY---FIGVLDIAGFEIFDFNSFEQLCINFTNEKL 485
Cdd:cd14889   304 EQIQRHHTKQQAEDARDSIAKVAYGRVFGWIVSKINQLLAPKDDSSVelrEIGILDIFGFENFAVNRFEQACINLANEQL 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  486 QQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDL-IEKPMGIMSILEEECMFPKATDMTFKAKLfDNHLGKSANFQ 564
Cdd:cd14889   384 QYFFNHHIFLMEQKEYKKEGIDWKEITY-KDNKPILDLfLNKPIGILSLLDEQSHFPQATDESFVDKL-NIHFKGNSYYG 461

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  565 KPRNIKGKpeahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSF 644
Cdd:cd14889   462 KSRSKSPK----FTVNHYAGKVTYNASGFLEKNRDTIPASIRTLFINSATPLLSVLFTATRSRTGTLMPRAKLPQAGSDN 537

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  645 ------QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDF 718
Cdd:cd14889   538 fnstrkQSVGAQFKHSLGVLMEKMFAASPHFVRCIKPNHVKVPGQLDSKYIQDQLRYNGLLETIRIRREGFSWRPSFAEF 617

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 119586555  719 RQRYRIL-NPAAIPegqfiDSRKGAEKLLSSLDIdhNQYKFGHTKVFFK 766
Cdd:cd14889   618 AERYKILlCEPALP-----GTKQSCLRILKATKL--VGWKCGKTRLFFK 659
MYSc_Myo46 cd14907
class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much ...
 101-766 5.83e-139

class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276872 [Multi-domain]  Cd Length: 669  Bit Score: 448.71  E-value: 5.83e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGK--------KRSEAPPHIFSISDNAYQYMLTDREN 171
Cdd:cd14907     3 LLINLKKRYQQDKIFTYVGPTLIVMNPYKQIDnLFSEEVMQMYKEQiiqngeyfDIKKEPPHIYAIAALAFKQLFENNKK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  172 QSILITGESGAGKTVNTKRVIQYFAVIAA--------IGDRSKKDQ-SPGKGTLEDQIIQANPALEAFGNAKTVRNDNSS 242
Cdd:cd14907    83 QAIVISGESGAGKTENAKYAMKFLTQLSQqeqnseevLTLTSSIRAtSKSTKSIEQKILSCNPILEAFGNAKTVRNDNSS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  243 RFGKFIRIHFG-ATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNP--YDYAFISQGET- 318
Cdd:cd14907   163 RFGKYVSILVDkKKRKILGARIQNYLLEKSRVTQQGQGERNYHIFYHLLYGADQQLLQQLGLKNQLsgDRYDYLKKSNCy 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  319 TVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQ--REEQAEPDGTEEADKSAYLMGLNSADLL 396
Cdd:cd14907   243 EVDTINDEKLFKEVQQSFQTLGFTEEEQDSIWRILAAILLLGNLQFDDSTldDNSPCCVKNKETLQIIAKLLGIDEEELK 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  397 KGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL--------ETKQPRQYFIGVLDIAGFEIF 468
Cdd:cd14907   323 EALTTKIRKVGNQVITSPLSKKECINNRDSLSKELYDRLFNWLVERLNDTImpkdekdqQLFQNKYLSIGLLDIFGFEVF 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  469 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTF--IDFgMDLQACIDLIEK-PMGIMSILEEECMFPKATD 545
Cdd:cd14907   403 QNNSFEQLCINYTNEKLQQLYISYVFKAEEQEFKEEGLEDYLnqLSY-TDNQDVIDLLDKpPIGIFNLLDDSCKLATGTD 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  546 MTFKAKLFDNHlGKSANFQKPRNIKGKpeaHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFanYA 625
Cdd:cd14907   482 EKLLNKIKKQH-KNNSKLIFPNKINKD---TFTIRHTAKEVEYNIEGFREKNKDEISQSIINCIQNSKNRIISSIF--SG 555

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  626 GADAPIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRIC 705
Cdd:cd14907   556 EDGSQQQNQSKQKKSQKKDKFLGSKFRNQMKQLMNELMQCDVHFIRCIKPNEEKKADLFIQGYVLNQIRYLGVLESIRVR 635

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555  706 RKGFPNRILYGDFRQRYRILNpaaipegqfidsrkgaekllssldidhNQYKFGHTKVFFK 766
Cdd:cd14907   636 KQGYPYRKSYEDFYKQYSLLK---------------------------KNVLFGKTKIFMK 669
MYSc_Myo30 cd14891
class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal ...
 99-766 3.02e-134

class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal SH3-like domain, two IQ motifs, a coiled-coil region and a PX domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276856  Cd Length: 645  Bit Score: 434.86  E-value: 3.02e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGS--WMIYTYSGLFCVTVNPYKWLPvyTPEVvAAYRGKKRSEAPPHIFSISDNAYQYMLTDRE---NQS 173
Cdd:cd14891     1 AGILHNLEERSKLdnQRPYTFMANVLIAVNPLRRLP--EPDK-SDYINTPLDPCPPHPYAIAEMAYQQMCLGSGrmqNQS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  174 ILITGESGAGKTVNTKRVIQY--------FAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFG 245
Cdd:cd14891    78 IVISGESGAGKTETSKIILRFlttravggKKASGQDIEQSSKKRKLSVTSLDERLMDTNPILESFGNAKTLRNHNSSRFG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  246 KFIRIHFGATG-KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITnNPYDYAFISQ-GETTVASI 323
Cdd:cd14891   158 KFMKLQFTKDKfKLAGAFIETYLLEKSRLVAQPPGERNFHIFYQLLAGASAELLKELLLL-SPEDFIYLNQsGCVSDDNI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  324 DDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKlKQREEQAEPDGTEEADK-----SAYLMGLNSADLLKG 398
Cdd:cd14891   237 DDAANFDNVVSALDTVGIDEDLQLQIWRILAGLLHLGNIEFD-EEDTSEGEAEIASESDKealatAAELLGVDEEALEKV 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  399 LCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFD-FNSFEQLC 477
Cdd:cd14891   316 ITQREIVTRGETFTIKRNAREAVYSRDAIAKSIYERLFLWIVQQINTSLGHDPDPLPYIGVLDIFGFESFEtKNDFEQLL 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  478 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLFDNH 556
Cdd:cd14891   396 INYANEALQATFNQQVFIAEQELYKSEGIDVGVITWP-DNRECLDLIaSKPNGILPLLDNEARNPNPSDAKLNETLHKTH 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  557 lGKSANFQKPRNiKGKPEAhFSLIHYAGIVDYNIIGWLQKNKDPLNETvvglyqksslklLSTLFANyagadapiekgkg 636
Cdd:cd14891   475 -KRHPCFPRPHP-KDMREM-FIVKHYAGTVSYTIGSFIDKNNDIIPED------------FEDLLAS------------- 526

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  637 kakkgssfqtvSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 716
Cdd:cd14891   527 -----------SAKFSDQMQELVDTLEATRCNFIRCIKPNAAMKVGVFDNRYVVDQLRCSGILQTCEVLKVGLPTRVTYA 595

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555  717 DFRQRYRILNPAAI------PEGQFIdsrkgaEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14891   596 ELVDVYKPVLPPSVtrlfaeNDRTLT------QAILWAFRVPSDAYRLGRTRVFFR 645
MYSc_Myo41 cd14902
class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much ...
 99-727 3.24e-134

class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276867 [Multi-domain]  Cd Length: 716  Bit Score: 437.40  E-value: 3.24e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYR--------GKKRSEAPPHIFSISDNAYQYML-TD 168
Cdd:cd14902     1 AALLQALSERFEHDQIYTSIGDILVALNPLKPLPdLYSESQLNAYKasmtstspVSQLSELPPHVFAIGGKAFGGLLkPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  169 RENQSILITGESGAGKTVNTKRVIQYFAviaAIGDRSKKDQSPGKGTLE--DQIIQANPALEAFGNAKTVRNDNSSRFGK 246
Cdd:cd14902    81 RRNQSILVSGESGSGKTESTKFLMQFLT---SVGRDQSSTEQEGSDAVEigKRILQTNPILESFGNAQTIRNDNSSRFGK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  247 FIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNpYDYAFISQGETTVA----- 321
Cdd:cd14902   158 FIKIQFGANNEIVGAQIVSYLLEKVRLLHQSPEERSFHIFYELLEGADKTLLDLLGLQKG-GKYELLNSYGPSFArkrav 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  322 SIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEA---DKSAYLMGLNSADLLKG 398
Cdd:cd14902   237 ADKYAQLYVETVRAFEDTGVGELERLDIFKILAALLHLGNVNFTAENGQEDATAVTAASRfhlAKCAELMGVDVDKLETL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  399 LCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRIN-------ATLETKQPRQYF--IGVLDIAGFEIFD 469
Cdd:cd14902   317 LSSREIKAGVEVMVLKLTPEQAKEICGSLAKAIYGRLFTWLVRRLSdeinyfdSAVSISDEDEELatIGILDIFGFESLN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  470 FNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLqACIDLIE-KPMGIMSILEEECMFPKATDMTF 548
Cdd:cd14902   397 RNGFEQLCINYANERLQAQFNEFVFVKEQQIYIAEGIDWKNISYPSNA-ACLALFDdKSNGLFSLLDQECLMPKGSNQAL 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  549 KAKLFDNHLgksanfqkprnikgkPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGAD 628
Cdd:cd14902   476 STKFYRYHG---------------GLGQFVVHHFAGRVCYNVEQFVEKNTDALPADASDILSSSSNEVVVAIGADENRDS 540

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  629 APIEKGKGKAKKGSSFQT--VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICR 706
Cdd:cd14902   541 PGADNGAAGRRRYSMLRApsVSAQFKSQLDRLIVQIGRTEAHYVRCLKPNEVKKPGIFDRERMVEQMRSVGVLEAVRIAR 620

                         650       660
                  ....*....|....*....|.
gi 119586555  707 KGFPNRILYGDFRQRYRILNP 727
Cdd:cd14902   621 HGYSVRLAHASFIELFSGFKC 641
MYSc_Myo47 cd14908
class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not ...
 99-727 6.33e-132

class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not much is known about this myosin class. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276873 [Multi-domain]  Cd Length: 682  Bit Score: 429.71  E-value: 6.33e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYR--GKKRS---EAP----PHIFSISDNAYQYMLTD- 168
Cdd:cd14908     1 PAILHSLSRRFFRGIIYTWTGPVLIAVNPFQRLPLYGKEILESYRqeGLLRSqgiESPqalgPHVFAIADRSYRQMMSEi 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  169 RENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKD-QSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKF 247
Cdd:cd14908    81 RASQSILISGESGAGKTESTKIVMLYLTTLGNGEEGAPNEgEELGKLSIMDRVLQSNPILEAFGNARTLRNDNSSRFGKF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  248 IRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQIL------SNKKPELLDMLLITNN-PYDYAFISQGET-T 319
Cdd:cd14908   161 IELGFNRAGNLLGAKVQTYLLEKVRLPFHASGERNYHIFYQLLrggdeeEHEKYEFHDGITGGLQlPNEFHYTGQGGApD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  320 VASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAY---LMGLNSADLL 396
Cdd:cd14908   241 LREFTDEDGLVYTLKAMRTMGWEESSIDTILDIIAGLLHLGQLEFESKEEDGAAEIAEEGNEKCLARvakLLGVDVDKLL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  397 KGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL--ETKQPRQYFIGVLDIAGFEIFDFNSFE 474
Cdd:cd14908   321 RALTSKIIVVRGKEITTKLTPHKAYDARDALAKTIYGALFLWVVATVNSSInwENDKDIRSSVGVLDIFGFECFAHNSFE 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  475 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFP-KATDMTFKAKL 552
Cdd:cd14908   401 QLCINFTNEALQQQFNQFIFKLEQKEYEKESIEWAFIEFP-DNQDCLDTIQaKKKGILTMLDDECRLGiRGSDANYASRL 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  553 FDNHL-------GKSANFQKPRNIKGKpeAHFSLIHYAGIVDYNI-IGWLQKNKDPLNETVVGLYQKsslkllSTLFany 624
Cdd:cd14908   480 YETYLpeknqthSENTRFEATSIQKTK--LIFAVRHFAGQVQYTVeTTFCEKNKDEIPLTADSLFES------GQQF--- 548

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  625 agadapiekgkgkakkgssfqtvsalhRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRI 704
Cdd:cd14908   549 ---------------------------KAQLHSLIEMIEDTDPHYIRCIKPNDAAKPDLVTRKRVTEQLRYGGVLEAVRV 601

                         650       660
                  ....*....|....*....|...
gi 119586555  705 CRKGFPNRILYGDFRQRYRILNP 727
Cdd:cd14908   602 ARSGYPVRLPHKDFFKRYRMLLP 624
MYSc_Myo35 cd14896
class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 ...
 99-766 4.38e-129

class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 domains, a single FERM domain, and an SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276861 [Multi-domain]  Cd Length: 644  Bit Score: 420.34  E-value: 4.38e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14896     1 SSVLLCLKKRFHLGRIYTFGGPILLSLNPHRSLPLFSEEVLASYHPRKALNTTPHIFAIAASAYRLSQSTGQDQCILLSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYfavIAAIGDRSKKDQspgkgtlEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgATGKL 258
Cdd:cd14896    81 HSGSGKTEAAKKIVQF---LSSLYQDQTEDR-------LRQPEDVLPILESFGHAKTILNANASRFGQVLRLHL-QHGVI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItNNPYDYAFISQGET-TVASIDDAEELMATDNAFD 337
Cdd:cd14896   150 VGASVSHYLLETSRVVFQAQAERSFHVFYELLAGLDPEEREQLSL-QGPETYYYLNQGGAcRLQGKEDAQDFEGLLKALQ 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  338 VLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQRE--EQAEPDGTEEADKSAYLMGLnSADLLKGLCHPRVKVGN-EYVTKG 414
Cdd:cd14896   229 GLGLCAEELTAIWAVLAAILQLGNICFSSSEREsqEVAAVSSWAEIHTAARLLQV-PPERLEGAVTHRVTETPyGRVSRP 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  415 QNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYF--IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHH 492
Cdd:cd14896   308 LPVEGAIDARDALAKTLYSRLFTWLLKRINAWLAPPGEAESDatIGVVDAYGFEALRVNGLEQLCINLASERLQLFSSQT 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  493 MFVLEQEEYKKEGIEWTFIDfGMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNikg 571
Cdd:cd14896   388 LLAQEEEECQRELLPWVPIP-QPPRESCLDLLvDQPHSLLSILDDQTWLSQATDHTFLQKCHYHH-GDHPSYAKPQL--- 462

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  572 kPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANyagADAPIEKGKGKAKKGSSFQtvsalh 651
Cdd:cd14896   463 -PLPVFTVRHYAGTVTYQVHKFLNRNRDQLDPAVVEMLAQSQLQLVGSLFQE---AEPQYGLGQGKPTLASRFQ------ 532

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  652 rENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILnpAAIP 731
Cdd:cd14896   533 -QSLGDLTARLGRSHVYFIHCLNPNPGKLPGLFDVGHVTEQLRQAGILEAIGTRSEGFPVRVPFQAFLARFGAL--GSER 609

                         650       660       670
                  ....*....|....*....|....*....|....*
gi 119586555  732 EGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14896   610 QEALSDRERCGAILSQVLGAESPLYHLGATKVLLK 644
PTZ00014 PTZ00014
myosin-A; Provisional
 62-819 1.02e-128

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 425.21  E-value: 1.02e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   62 ETEYGKTVTVKEDQVMQQNPP-KFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVA 140
Cdd:PTZ00014   72 DPPTNSTFEVKPEHAFNANSQiDPMTYGDIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNTTNDWIR 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  141 AYR-GKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAViAAIGDRSKKDQspgkgtleDQ 219
Cdd:PTZ00014  152 RYRdAKDSDKLPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFAS-SKSGNMDLKIQ--------NA 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  220 IIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLD 299
Cdd:PTZ00014  223 IMAANPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYHIFYQLLKGANDEMKE 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  300 MLLITNNPyDYAFISQGETTVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFklKQREEQAEPDGTE 379
Cdd:PTZ00014  303 KYKLKSLE-EYKYINPKCLDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGNVEI--EGKEEGGLTDAAA 379

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  380 EADKS-------AYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQP 452
Cdd:PTZ00014  380 ISDESlevfneaCELLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLFLWIIRNLNATIEPPGG 459

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  453 RQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGI-----EWTfidfgmDLQACIDLI-EK 526
Cdd:PTZ00014  460 FKVFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGIsteelEYT------SNESVIDLLcGK 533

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  527 PMGIMSILEEECMFPKATDMTFKAKLFdNHLGKSANFQKPRNIKGKpeaHFSLIHYAGIVDYNIIGWLQKNKDPLNETVV 606
Cdd:PTZ00014  534 GKSVLSILEDQCLAPGGTDEKFVSSCN-TNLKNNPKYKPAKVDSNK---NFVIKHTIGDIQYCASGFLFKNKDVLRPELV 609

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  607 GLYQKSSLKLLSTLFanyagADAPIEKGKGKAKKGSSFQTVsalhrENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDN 686
Cdd:PTZ00014  610 EVVKASPNPLVRDLF-----EGVEVEKGKLAKGQLIGSQFL-----NQLDSLMSLINSTEPHFIRCIKPNENKKPLDWNS 679

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  687 PLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNpAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:PTZ00014  680 SKVLIQLHSLSILEALQLRQLGFSYRRTFAEFLSQFKYLD-LAVSNDSSLDPKEKAEKLLERSGLPKDSYAIGKTMVFLK 758

                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555  767 AGLLGLLEEMRDERLSR---IITRIQAQSRGVLARmeyKKLLERRDSLLVIQWNIR 819
Cdd:PTZ00014  759 KDAAKELTQIQREKLAAwepLVSVLEALILKIKKK---RKVRKNIKSLVRIQAHLR 811
MYSc_Myo34 cd14895
class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short ...
 99-766 1.69e-120

class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short coiled-coil region, 5 tandem ANK repeats, and a carboxy-terminal FYVE domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276860 [Multi-domain]  Cd Length: 704  Bit Score: 398.17  E-value: 1.69e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTpevVAAYRGK--KRSEAPPHIFSISDNAYQYMLT-------D 168
Cdd:cd14895     1 PAFVDYLAQRYGVDQVYCRSGAVLIAVNPFKHIPgLYD---LHKYREEmpGWTALPPHVFSIAEGAYRSLRRrlhepgaS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  169 RENQSILITGESGAGKTVNTKRVIQYFAVIA----AIGDRSKKDQSPGkgtleDQIIQANPALEAFGNAKTVRNDNSSRF 244
Cdd:cd14895    78 KKNQTILVSGESGAGKTETTKFIMNYLAESSkhttATSSSKRRRAISG-----SELLSANPILESFGNARTLRNDNSSRF 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  245 GKFIRIHFG-----ATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDML-LITNNPYDYAFISQGET 318
Cdd:cd14895   153 GKFVRMFFEgheldTSLRMIGTSVETYLLEKVRVVHQNDGERNFHVFYELLAGAADDMKLELqLELLSAQEFQYISGGQC 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  319 TVAS--IDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGT------------------ 378
Cdd:cd14895   233 YQRNdgVRDDKQFQLVLQSMKVLGFTDVEQAAIWKILSALLHLGNVLFVASSEDEGEEDNGAasapcrlasaspssltvq 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  379 EEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQY--- 455
Cdd:cd14895   313 QHLDIVSKLFAVDQDELVSALTTRKISVGGETFHANLSLAQCGDARDAMARSLYAFLFQFLVSKVNSASPQRQFALNpnk 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  456 --------FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-K 526
Cdd:cd14895   393 aankdttpCIAVLDIFGFEEFEVNQFEQFCINYANEKLQYQFIQDILLTEQQAHIEEGIKWNAVDYE-DNSVCLEMLEqR 471

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  527 PMGIMSILEEECMFPKATDMTFKAKLFdNHLGKSANFQKPRniKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVV 606
Cdd:cd14895   472 PSGIFSLLDEECVVPKGSDAGFARKLY-QRLQEHSNFSASR--TDQADVAFQIHHYAGAVRYQAEGFCEKNKDQPNAELF 548

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  607 GLYQKSSLKLLSTLFANY-AGADAPIEKGKGKAKKGSSFQT---VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPG 682
Cdd:cd14895   549 SVLGKTSDAHLRELFEFFkASESAELSLGQPKLRRRSSVLSsvgIGSQFKQQLASLLDVVQQTQTHYIRCIKPNDESASD 628

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  683 VMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPegqfidSRKGAEKLLSSLDIDHNQykFGHTK 762
Cdd:cd14895   629 QFDMAKVSSQLRYGGVLKAVEIMRQSYPVRMKHADFVKQYRLLVAAKNA------SDATASALIETLKVDHAE--LGKTR 700


                  ....
gi 119586555  763 VFFK 766
Cdd:cd14895   701 VFLR 704
MYSc_Myo14 cd14876
class XIV myosin, motor domain; These myosins localize to plasma membranes of the ...
 99-766 2.88e-119

class XIV myosin, motor domain; These myosins localize to plasma membranes of the intracellular parasites and may be involved in the cell invasion process. Their known functions include: transporting phagosomes to the nucleus and perturbing the developmentally regulated elimination of the macronucleus during conjugation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to their motor domain these myosins have a MyTH4-FERM protein domain combination. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276843  Cd Length: 649  Bit Score: 392.81  E-value: 2.88e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRG-KKRSEAPPHIFSIS----DNAYQYmltdRENQS 173
Cdd:cd14876     1 PCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNATDEWIRKYRDaPDLTKLPPHVFYTArralENLHGV----NKSQT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  174 ILITGESGAGKTVNTKRVIQYFAViaaigdrSKKDQSPGKgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFG 253
Cdd:cd14876    77 IIVSGESGAGKTEATKQIMRYFAS-------AKSGNMDLR--IQTAIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLDVA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  254 ATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLD--MLLITNnpyDYAFISQGETTVASIDDAEELMA 331
Cdd:cd14876   148 SEGGIRYGSVVAFLLEKSRIVTQDDNERSYHIFYQLLKGADSEMKSkyHLLGLK---EYKFLNPKCLDVPGIDDVADFEE 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  332 TDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQ-----AEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKV 406
Cdd:cd14876   225 VLESLKSMGLTEEQIDTVFSIVSGVLLLGNVKITGKTEQGVddaaaISNESLEVFKEACSLLFLDPEALKRELTVKVTKA 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  407 GNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQ 486
Cdd:cd14876   305 GGQEIEGRWTKDDAEMLKLSLAKAMYDKLFLWIIRNLNSTIEPPGGFKNFMGMLDIFGFEVFKNNSLEQLFINITNEMLQ 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  487 QFFNHHMFVLEQEEYKKEGI-----EWTfidfgmDLQACID-LIEKPMGIMSILEEECMFPKATDMTFKAKLFDNhLGKS 560
Cdd:cd14876   385 KNFIDIVFERESKLYKDEGIptaelEYT------SNAEVIDvLCGKGKSVLSILEDQCLAPGGSDEKFVSACVSK-LKSN 457

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  561 ANFQKprnIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANyagadAPIEKGKGKAKK 640
Cdd:cd14876   458 GKFKP---AKVDSNINFIVVHTIGDIQYNAEGFLFKNKDVLRAELVEVVQASTNPVVKALFEG-----VVVEKGKIAKGS 529

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  641 GSSFQTVSalhreNLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQ 720
Cdd:cd14876   530 LIGSQFLK-----QLESLMGLINSTEPHFIRCIKPNETKKPLEWNSSKVLIQLHALSILEALQLRQLGYSYRRPFEEFLY 604

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*.
gi 119586555  721 RYRILNPaAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14876   605 QFKFLDL-GIANDKSLDPKVAALKLLESSGLSEDEYAIGKTMVFLK 649
MYSc_Myo19 cd14880
class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor ...
 101-764 6.16e-112

class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor for mitochondrial movement in vertebrate cells. It contains a variable number of IQ domains. Human myo19 contains a motor domain, three IQ motifs, and a short tail. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276846 [Multi-domain]  Cd Length: 658  Bit Score: 371.88  E-value: 6.16e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEA-PPHIFSISDNAYQYMLTDRE--NQSILI 176
Cdd:cd14880     3 VLRCLQARYTADTFYTNAGCTLVALNPFKPVPqLYSPELMREYHAAPQPQKlKPHIFTVGEQTYRNVKSLIEpvNQSIVV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  177 TGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14880    83 SGESGAGKTWTSRCLMKFYAVVAASPTSWESHKIAER--IEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILsnkKPELLDMLLITNNP--YDYAFISQGETTVASiDDAEelmATDN 334
Cdd:cd14880   161 QMTGAAVQTYLLEKTRVACQAPSERNFHIFYQIC---KGASADERLQWHLPegAAFSWLPNPERNLEE-DCFE---VTRE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  335 AFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQA---EPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYV 411
Cdd:cd14880   234 AMLHLGIDTPTQNNIFKVLAGLLHLGNIQFADSEDEAQPcqpMDDTKESVRTSALLLKLPEDHLLETLQIRTIRAGKQQQ 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  412 TKGQNVQQVIYAT--GALAKAVYERMFNWMVTRINATLETKQPR-QYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQF 488
Cdd:cd14880   314 VFKKPCSRAECDTrrDCLAKLIYARLFDWLVSVINSSICADTDSwTTFIGLLDVYGFESFPENSLEQLCINYANEKLQQH 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  489 FNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDmtfkAKLFDNHLGKS-ANFQKP 566
Cdd:cd14880   394 FVAHYLRAQQEEYAVEGLEWSFINY-QDNQTCLDLIEgSPISICSLINEECRLNRPSS----AAQLQTRIESAlAGNPCL 468

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  567 RNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEkgkGKAKKGSSFQT 646
Cdd:cd14880   469 GHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPVPPELTRLLQQSQDPLLQKLFPANPEEKTQEE---PSGQSRAPVLT 545

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  647 VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL- 725
Cdd:cd14880   546 VVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQCQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHQNFVERYKLLr 625

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|.
gi 119586555  726 --NPAAIPEGQFIDSRKGAEKLLSSldidhnqykfGHTKVF 764
Cdd:cd14880   626 rlRPHTSSGPHSPYPAKGLSEPVHC----------GRTKVF 656
MYSc_Myo38 cd14899
class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is ...
 100-723 4.49e-107

class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276864 [Multi-domain]  Cd Length: 717  Bit Score: 360.18  E-value: 4.49e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYR-------GKKRSEA---PPHIFSISDNAYQYMLTD 168
Cdd:cd14899     2 SILNALRLRYERHAIYTHIGDILISINPFQDLPqLYGDEILRGYAydhnsqfGDRVTSTdprEPHLFAVARAAYIDIVQN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  169 RENQSILITGESGAGKTVNTKRVIQYFAV-------IAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNS 241
Cdd:cd14899    82 GRSQSILISGESGAGKTEATKIIMTYFAVhcgtgnnNLTNSESISPPASPSRTTIEEQVLQSNPILEAFGNARTVRNDNS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  242 SRFGKFIRIHF-GATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNK----KPELLDMLLITNNPYDYAFISQG 316
Cdd:cd14899   162 SRFGKFIELRFrDERRRLAGARIRTYLLEKIRVIKQAPHERNFHIFYELLSADnncvSKEQKQVLALSGGPQSFRLLNQS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  317 ETTVA--SIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKL--KQREEQAEPDGTEEA----------D 382
Cdd:cd14899   242 LCSKRrdGVKDGVQFRATKRAMQQLGMSEGEIGGVLEIVAAVLHMGNVDFEQipHKGDDTVFADEARVMssttgafdhfT 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  383 KSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQY------- 455
Cdd:cd14899   322 KAAELLGVSTEALDHALTKRWLHASNETLVVGVDVAHARNTRNALTMECYRLLFEWLVARVNNKLQRQASAPWgadesdv 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  456 --------FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDlQACIDLIE-K 526
Cdd:cd14899   402 ddeedatdFIGLLDIFGFEDMAENSFEQLCINYANEALQHQFNQYIFEEEQRLYRDEGIRWSFVDFPNN-RACLELFEhR 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  527 PMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVV 606
Cdd:cd14899   481 PIGIFSLTDQECVFPQGTDRALVAKYYLEFEKKNSHPHFRSAPLIQRTTQFVVAHYAGCVTYTIDGFLAKNKDSFCESAA 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  607 GLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSAL--------HRENLNKLMTNLRSTHPHFVRCIIPNET 678
Cdd:cd14899   561 QLLAGSSNPLIQALAAGSNDEDANGDSELDGFGGRTRRRAKSAIaavsvgtqFKIQLNELLSTVRATTPRYVRCIKPNDS 640

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*
gi 119586555  679 KSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 723
Cdd:cd14899   641 HVGSLFQSTRVVEQLRSGGVLEAVRVARAGFPVRLTHKQFLGRYR 685
MYSc_Myo13 cd14875
class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain ...
 101-766 2.49e-106

class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain binding domain, and a C-terminal GPA/Q-rich domain. There is little known about the function of this myosin class. Two of the earliest members identified in this class are green alga Acetabularia cliftonii, Aclmyo1 and Aclmyo2. They are striking with their short tail of Aclmyo1 of 18 residues and the maximum of 7 IQ motifs in Aclmyo2. It is thought that these myosins are involved in organelle transport and tip growth. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276842 [Multi-domain]  Cd Length: 664  Bit Score: 356.04  E-value: 2.49e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  101 VLYNLKDRYGSWMI-YTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEA-PPHIFSISDNAY-QYMLTDRENQSILIT 177
Cdd:cd14875     3 LLHCIKERFEKLHQqYSLMGEMVLSVNPFRLMPFNSEEERKKYLALPDPRLlPPHIWQVAHKAFnAIFVQGLGNQSVVIS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  178 GESGAGKTVNTKRVIQYFAVIAAIgdRSKkdqSPGKGTLEDQIIQ----ANPALEAFGNAKTVRNDNSSRFGKFIRIHF- 252
Cdd:cd14875    83 GESGSGKTENAKMLIAYLGQLSYM--HSS---NTSQRSIADKIDEnlkwSNPVMESFGNARTVRNDNSSRFGKYIKLYFd 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  253 GATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTV------ASIDDA 326
Cdd:cd14875   158 PTSGVMVGGQTVTYLLEKSRIIMQSPGERNYHIFYEMLAGLSPEEKKELGGLKTAQDYKCLNGGNTFVrrgvdgKTLDDA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  327 EELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEAdKSAYLMGLNSADLLKGLChprVKV 406
Cdd:cd14875   238 HEFQNVRHALSMIGVELETQNSIFRVLASILHLMEVEFESDQNDKAQIADETPFL-TACRLLQLDPAKLRECFL---VKS 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  407 GNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLetkQPRQ-----YFIGVLDIAGFEIFDFNSFEQLCINFT 481
Cdd:cd14875   314 KTSLVTILANKTEAEGFRNAFCKAIYVGLFDRLVEFVNASI---TPQGdcsgcKYIGLLDIFGFENFTRNSFEQLCINYA 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  482 NEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKS 560
Cdd:cd14875   391 NESLQNHYNKYTFINDEEECRREGIQIPKIEFP-DNSECVNMFDqKRTGIFSMLDEECNFKGGTTERFTTNLWDQWANKS 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  561 ANFQKPrniKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADapiekgkgkakk 640
Cdd:cd14875   470 PYFVLP---KSTIPNQFGVNHYAAFVNYNTDEWLEKNTDALKEDMYECVSNSTDEFIRTLLSTEKGLA------------ 534

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  641 gSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDF-R 719
Cdd:cd14875   535 -RRKQTVAIRFQRQLTDLRTELESTETQFIRCIKPNMEASPSFLDNLLVGSQLESAGVLQTIALKRQGYPVRRPIEQFcR 613

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|.
gi 119586555  720 QRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHN----QYKFGHTKVFFK 766
Cdd:cd14875   614 YFYLIMPRSTASLFKQEKYSEAAKDFLAYYQRLYGwakpNYAVGKTKVFLR 664
MYSc_Myo45 cd14906
class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds ...
 101-726 6.59e-106

class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds Dictyostelium and Polysphondylium. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276871 [Multi-domain]  Cd Length: 715  Bit Score: 356.60  E-value: 6.59e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKR-SEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14906     3 ILNNLGKRYKSDSIYTYIGNVLISINPYKDISsIYSNLILNEYKDINQnKSPIPHIYAVALRAYQSMVSEKKNQSIIISG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT-GK 257
Cdd:cd14906    83 ESGSGKTEASKTILQYLINTSSSNQQQNNNNNNNNNSIEKDILTSNPILEAFGNSRTTKNHNSSRFGKFLKIEFRSSdGK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  258 LASADIETYLLEKSRVIFQL-KAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASI------------- 323
Cdd:cd14906   163 IDGASIETYLLEKSRISHRPdNINLSYHIFYYLVYGASKDERSKWGLNNDPSKYRYLDARDDVISSFksqssnknsnhnn 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  324 --DDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQ---REEQAEPDGTEEADKSAYLMGLNSADLLKG 398
Cdd:cd14906   243 ktESIESFQLLKQSMESMSINKEQCDAIFLSLAAILHLGNIEFEEDSdfsKYAYQKDKVTASLESVSKLLGYIESVFKQA 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  399 LCHPRVKVGNE--YVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINAT-LETKQPRQ----------YFIGVLDIAGF 465
Cdd:cd14906   323 LLNRNLKAGGRgsVYCRPMEVAQSEQTRDALSKSLYVRLFKYIVEKINRKfNQNTQSNDlaggsnkknnLFIGVLDIFGF 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  466 EIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKAT 544
Cdd:cd14906   403 ENLSSNSLEQLLINFTNEKLQQQFNLNVFENEQKEYLSEGIPWSNSNF-IDNKECIELIEkKSDGILSLLDDECIMPKGS 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  545 DMTFKAKLfdNHLGKSANFQKPRNI-KGKpeahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFan 623
Cdd:cd14906   482 EQSLLEKY--NKQYHNTNQYYQRTLaKGT----LGIKHFAGDVTYQTDGWLEKNRDSLYSDVEDLLLASSNFLKKSLF-- 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  624 yagaDAPIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIR 703
Cdd:cd14906   554 ----QQQITSTTNTTKKQTQSNTVSGQFLEQLNQLIQTINSTSVHYIRCIKPNQTMDCNNFNNVHVLSQLRNVGVLNTIK 629

                         650       660
                  ....*....|....*....|...
gi 119586555  704 ICRKGFPNRILYGDFRQRYRILN 726
Cdd:cd14906   630 VRKMGYSYRRDFNQFFSRYKCIV 652
MYSc_Myo18 cd01386
class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain ...
 101-766 2.33e-103

class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain which is commonly found in proteins establishing molecular complexes. The motor domain itself does not exhibit ATPase activity, suggesting that it functions as an actin tether protein. It also has two IQ domains that probably bind light chains or related calmodulins and a C-terminal tail with two sections of coiled-coil domains, which are thought to mediate homodimerization. The function of these myosins are largely unknown. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276837 [Multi-domain]  Cd Length: 689  Bit Score: 348.15  E-value: 2.33e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd01386     3 VLHTLRQRYGANLIHTYAGPSLIVINPRHPLAVYSEKVAKMFKGCRREDMPPHIYASAQSAYRAMLMSRRDQSIVLLGRS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  181 GAGKTVNTKRVIQYFAVIAAIgdrSKKDQSPGKgtledqiIQA-NPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd01386    83 GSGKTTNCRHILEYLVTAAGS---VGGVLSVEK-------LNAaLTVLEAFGNVRTALNGNATRFSQLFSLDFDQAGQLA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFisqGETTVASIDD----AEELMATDNA 335
Cdd:cd01386   153 SASIQTLLLERSRVARRPEGESNFNVFYYLLAGADAALRTELHLNQLAESNSF---GIVPLQKPEDkqkaAAAFSKLQAA 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  336 FDVLGFTSEEKNSMYKLTGAIMHFGN---MKFKLKQREEQAEPdgtEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVT 412
Cdd:cd01386   230 MKTLGISEEEQRAIWSILAAIYHLGAagaTKAASAGRKQFARP---EWAQRAAYLLGCTLEELSSAIFKHHLSGGPQQST 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  413 ---------------KGQNVQQviyATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFN------ 471
Cdd:cd01386   307 tssgqesparsssggPKLTGVE---ALEGFAAGLYSELFAAVVSLINRSLSSSHHSTSSITIVDTPGFQNPAHSgsqrga 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  472 SFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEK---------------PMGIMSILEE 536
Cdd:cd01386   384 TFEDLCHNYAQERLQLLFHERTFVAPLERYKQENVEVDFDLPELSPGALVALIDQapqqalvrsdlrdedRRGLLWLLDE 463

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  537 ECMFPKATDMTFKAKLFdNHLGKSANFQKPRNIKGKPEA-HFSLIHYAGI--VDYNIIGWLQKNK-DPLNETVVGLYQKS 612
Cdd:cd01386   464 EALYPGSSDDTFLERLF-SHYGDKEGGKGHSLLRRSEGPlQFVLGHLLGTnpVEYDVSGWLKAAKeNPSAQNATQLLQES 542

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  613 SlKLLSTLFANYAGADApiekgkgkakkgsSFQtvsalhrenLNKLMTNLRSTHPHFVRCIIPN------------ETKS 680
Cdd:cd01386   543 Q-KETAAVKRKSPCLQI-------------KFQ---------VDALIDTLRRTGLHFVHCLLPQhnagkderstssPAAG 599

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  681 PGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPA----AIPEGQFIDSRKGAEKLLSSLDIDHNQY 756
Cdd:cd01386   600 DELLDVPLLRSQLRGSQLLDALRLYRQGFPDHMPLGEFRRRFQVLAPPltkkLGLNSEVADERKAVEELLEELDLEKSSY 679

                         730
                  ....*....|
gi 119586555  757 KFGHTKVFFK 766
Cdd:cd01386   680 RIGLSQVFFR 689
MYSc_Myo25 cd14886
class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell ...
 105-766 4.27e-103

class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell adhesion and filopodia formation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276851  Cd Length: 650  Bit Score: 346.10  E-value: 4.27e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  105 LKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRS-----EAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14886     7 LRDRFAKDKIYTYAGKLLVALNPFKQIRnLYGTEVIGRYRQADTSrgfpsDLPPHSYAVAQSALNGLISDGISQSCIVSG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAViaaigdrskkDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14886    87 ESGAGKTETAKQLMNFFAY----------GHSTSSTDVQSLILGSNPLLESFGNAKTLRNNNSSRFGKFIKLLVGPDGGL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQI---LSNKKPELLDMLLITNnpydYAFISQGET-TVASIDDAEELMATDN 334
Cdd:cd14886   157 KGGKITSYMLELSRIEFQSTNERNYHIFYQCikgLSPEEKKSLGFKSLES----YNFLNASKCyDAPGIDDQKEFAPVRS 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  335 AFDVLgFTSEEKNSMYKLTGAIMHFGNMKFKLKQR---EEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYV 411
Cdd:cd14886   233 QLEKL-FSKNEIDSFYKCISGILLAGNIEFSEEGDmgvINAAKISNDEDFGKMCELLGIESSKAAQAIITKVVVINNETI 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  412 TKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNH 491
Cdd:cd14886   312 ISPVTQAQAEVNIRAVAKDLYGALFELCVDTLNEIIQFDADARPWIGILDIYGFEFFERNTYEQLLINYANERLQQYFIN 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  492 HMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEKP-MGIMSILEEECMFPKATDMTFKAKLfDNHLgKSANFqkprnIK 570
Cdd:cd14886   392 QVFKSEIQEYEIEGIDHSMITF-TDNSNVLAVFDKPnLSIFSFLEEQCLIQTGSSEKFTSSC-KSKI-KNNSF-----IP 463

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  571 GKPEA-HFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLstlfaNYAGADAPIEKGKGKAkkgssfQTVSA 649
Cdd:cd14886   464 GKGSQcNFTIVHTAATVTYNTEEFVDKNKHKLSVDILELLMGSTNPIV-----NKAFSDIPNEDGNMKG------KFLGS 532

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  650 LHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL---N 726
Cdd:cd14886   533 TFQLSIDQLMKTLSATKSHFIRCIKTNQDKVPNKYETKSVYNQLISLSIFESIQTIHRGFAYNDTFEEFFHRNKILishN 612

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 119586555  727 PAAIPEGQfiDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14886   613 SSSQNAGE--DLVEAVKSILENLGIPCSDYRIGKTKVFLR 650
MYSc_Myo37 cd14898
class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much ...
 100-741 4.35e-96

class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276863  Cd Length: 578  Bit Score: 323.39  E-value: 4.35e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKwlPVYTPEVVAAYRgKKRSEAPPHIFSISDNAYQYMLTdRENQSILITGE 179
Cdd:cd14898     2 ATLEILEKRYASGKIYTKSGLVFLALNPYE--TIYGAGAMKAYL-KNYSHVEPHVYDVAEASVQDLLV-HGNQTIVISGE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVIQYFAviaaigdrskkDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgaTGKLA 259
Cdd:cd14898    78 SGSGKTENAKLVIKYLV-----------ERTASTTSIEKLITAANLILEAFGNAKTQLNDNSSRFGKRIKLKF--DGKIT 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKpelldmLLITNNPYDYAFISQGETTVasIDDAEELMATDNAFDVL 339
Cdd:cd14898   145 GAKFETYLLEKSRVTHHEKGERNFHIFYQFCASKR------LNIKNDFIDTSSTAGNKESI--VQLSEKYKMTCSAMKSL 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  340 GFTSEEknSMYKLTGAIMHFGNMKFklkQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQ 419
Cdd:cd14898   217 GIANFK--SIEDCLLGILYLGSIQF---VNDGILKLQRNESFTEFCKLHNIQEEDFEESLVKFSIQVKGETIEVFNTLKQ 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  420 VIYATGALAKAVYERMFNWMVTRINATLETKQPRQyfIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQE 499
Cdd:cd14898   292 ARTIRNSMARLLYSNVFNYITASINNCLEGSGERS--ISVLDIFGFEIFESNGLDQLCINWTNEKIQNDFIKKMFRAKQG 369

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  500 EYKKEGIEWTFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKAT--DMTFKAKLFDNHlgksanfqkprNIKGKPEAHF 577
Cdd:cd14898   370 MYKEEGIEWPDVEF-FDNNQCIRDFEKPCGLMDLISEESFNAWGNvkNLLVKIKKYLNG-----------FINTKARDKI 437

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  578 SLIHYAGIVDYNIIGWLQKNKdplnetvvglyQKSSLKLLSTLFANYAGadapiekgkgkakkgsSFQTVSALHRENLNK 657
Cdd:cd14898   438 KVSHYAGDVEYDLRDFLDKNR-----------EKGQLLIFKNLLINDEG----------------SKEDLVKYFKDSMNK 490

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  658 LMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIpegQFID 737
Cdd:cd14898   491 LLNSINETQAKYIKCIRPNEECRPWCFDRDLVSKQLAECGILETIRLSKQCFPQEIPKDRFEERYRILGITLF---EVVD 567


                  ....
gi 119586555  738 SRKG 741
Cdd:cd14898   568 YRKG 571
MYSc_Myo16 cd14878
class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal ...
 100-725 2.81e-95

class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3/NYAP3. Myo16 is thought to play a regulatory role in cell cycle progression and has been recently implicated in Schizophrenia. Class XVI myosins are characterized by an N-terminal ankyrin repeat domain and some with chitin synthase domains that arose independently from the ones in the class XVII fungal myosins. They bind protein phosphatase 1 catalytic subunits 1alpha/PPP1CA and 1gamma/PPP1CC. Human Myo16 interacts with ACOT9, ARHGAP26 and PIK3R2 and with components of the WAVE1 complex, CYFIP1 and NCKAP1. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276844 [Multi-domain]  Cd Length: 656  Bit Score: 323.69  E-value: 2.81e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYR---GKKRSEAPPHIFSISDNAYQYMLTDRENQSILI 176
Cdd:cd14878     2 SLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSTMVSQLYLsssGQLCSSLPPHLFSCAERAFHQLFQERRPQCFIL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  177 TGESGAGKTVNTKRVIQYFAViaaigdRSkkdqSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14878    82 SGERGSGKTEASKQIMKHLTC------RA----SSSRTTFDSRFKHVNCILEAFGHAKTTLNDLSSCFIKYFELQFCERK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  257 K-LASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItNNPYDYAFISQGE----TTVASIDDAEELMA 331
Cdd:cd14878   152 KhLTGARIYTYMLEKSRLVSQPPGQSNFLIFYLLMDGLSAEEKYGLHL-NNLCAHRYLNQTMredvSTAERSLNREKLAV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  332 TDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYV 411
Cdd:cd14878   231 LKQALNVVGFSSLEVENLFVILSAILHLGDIRFTALTEADSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDMI 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  412 TKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL----ETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQ 487
Cdd:cd14878   311 IRRHTIQIAEFYRDLLAKSLYSRLFSFLVNTVNCCLqsqdEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHH 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  488 FFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLfdNHLGKSANFQ-- 564
Cdd:cd14878   391 YINEVLFLQEQTECVQEGVTMETAYSPGNQTGVLDFFfQKPSGFLSLLDEESQMIWSVEPNLPKKL--QSLLESSNTNav 468

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  565 ----KPRNIKGKPEAH---FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFanyagadapiekgkgk 637
Cdd:cd14878   469 yspmKDGNGNVALKDQgtaFTVMHYAGRVMYEIVGAIEKNKDSLSQNLLFVMKTSENVVINHLF---------------- 532

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  638 akkGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGD 717
Cdd:cd14878   533 ---QSKLVTIASQLRKSLADIIGKLQKCTPHFIHCIKPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSD 609


                  ....*...
gi 119586555  718 FRQRYRIL 725
Cdd:cd14878   610 FLSRYKPL 617
MYSc_Myo26 cd14887
class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the ...
 99-766 8.08e-91

class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the other myosins that have a MyTH4 domain such as class III, VII, IX, X , XV, XVI, XVII, XX, XXII, XXV, and XXXIV. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276852  Cd Length: 725  Bit Score: 312.74  E-value: 8.08e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGS--------WMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRE 170
Cdd:cd14887     1 PNLLENLYQRYNKayinkenrNCIYTYTGTLLIAVNPYRFFNLYDRQWISRFDTEANSRLVPHPFGLAEFAYCRLVRDRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  171 NQSILITGESGAGKTVNTKRVIQYfavIAAIGDRSKKDQSPGkgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRI 250
Cdd:cd14887    81 SQSILISGESGAGKTETSKHVLTY---LAAVSDRRHGADSQG---LEARLLQSGPVLEAFGNAHTVLNANSSRFGKMLLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  251 HFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKK-PELLDMLLITNNPYDYafisqgettvasiddaeEL 329
Cdd:cd14887   155 HFTGRGKLTRASVATYLLANERVVRIPSDEFSFHIFYALCNAAVaAATQKSSAGEGDPEST-----------------DL 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  330 MATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPD-------GTEE--ADKS--AYLMGLNS------ 392
Cdd:cd14887   218 RRITAAMKTVGIGGGEQADIFKLLAAILHLGNVEFTTDQEPETSKKRkltsvsvGCEEtaADRShsSEVKCLSSglkvte 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  393 ------ADLLKGLCHPRVKVGNEYV------------TKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQ 454
Cdd:cd14887   298 asrkhlKTVARLLGLPPGVEGEEMLrlalvsrsvretRSFFDLDGAAAARDAACKNLYSRAFDAVVARINAGLQRSAKPS 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  455 Y--------------FIGVLDIAGFEIF---DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEG--IEWTFIDFGM 515
Cdd:cd14887   378 EsdsdedtpsttgtqTIGILDLFGFEDLrnhSKNRLEQLCINYANERLHCFLLEQLILNEHMLYTQEGvfQNQDCSAFPF 457

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  516 DLQACIDLIEKP------------------------MGIMSILEEE-CMFPKATDMTFKAKLFDNHLGKSA-NFQKPRNI 569
Cdd:cd14887   458 SFPLASTLTSSPsstspfsptpsfrsssafatspslPSSLSSLSSSlSSSPPVWEGRDNSDLFYEKLNKNIiNSAKYKNI 537

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  570 K---GKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYqksslkllstLFANYAGADAPIEKGKGKAKKGSSFQT 646
Cdd:cd14887   538 TpalSRENLEFTVSHFACDVTYDARDFCRANREATSDELERLF----------LACSTYTRLVGSKKNSGVRAISSRRST 607

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  647 VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 726
Cdd:cd14887   608 LSAQFASQLQQVLKALQETSCHFIRCVKPNRVQEAGIFEDAYVHRQLRCSGMSDLLRVMADGFPCRLPYVELWRRYETKL 687

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|
gi 119586555  727 PAAIPEgqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14887   688 PMALRE--ALTPKMFCKIVLMFLEINSNSYTFGKTKIFFR 725
MYSc_Myo24A cd14937
class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
 101-766 1.50e-85

class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The function of the class XXIV myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276897  Cd Length: 637  Bit Score: 294.62  E-value: 1.50e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEvvaaYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd14937     3 VLNMLALRYKKNYIYTIAEPMLISINPYQVIDVDINE----YKNKNTNELPPHVYSYAKDAMTDFINTKTNQSIIISGES 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  181 GAGKTVNTKRVIQYFavIAAIgdrsKKDQSPGKgTLEDqiiqANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLAS 260
Cdd:cd14937    79 GSGKTEASKLVIKYY--LSGV----KEDNEISN-TLWD----SNFILEAFGNAKTLKNNNSSRYGKYIKIELDEYQNIVS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  261 ADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPyDYAFISQGETTVASIDDAEELMATDNAFDVLG 340
Cdd:cd14937   148 SSIEIFLLENIRVVSQEEEERGYHIFYQIFNGMSQELKNKYKIRSEN-EYKYIVNKNVVIPEIDDAKDFGNLMISFDKMN 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  341 FTSEEKNSMYKLTGAIMhFGNMKFKL-----KQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
Cdd:cd14937   227 MHDMKDDLFLTLSGLLL-LGNVEYQEiekggKTNCSELDKNNLELVNEISNLLGINYENLKDCLVFTEKTIANQKIEIPL 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  416 NVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd14937   306 SVEESVSICKSISKDLYNKIFSYITKRINNFLNNNKELNNYIGILDIFGFEIFSKNSLEQLLINIANEEIHSIYLYIVYE 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  496 LEQEEYKKEGIEWTFIDFGMDlQACIDLIEKPMGIMSILEEECMFPKATDMTFkAKLFDNHLGKSANFQKPRNIKGKpea 575
Cdd:cd14937   386 KETELYKAEDILIESVKYTTN-ESIIDLLRGKTSIISILEDSCLGPVKNDESI-VSVYTNKFSKHEKYASTKKDINK--- 460

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  576 HFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApiekgkgkakkGSSFQTVSALHRENL 655
Cdd:cd14937   461 NFVIKHTVSDVTYTITNFISKNKDILPSNIVRLLKVSNNKLVRSLYEDVEVSES-----------LGRKNLITFKYLKNL 529

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  656 NKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRIcRKGFPNRILYGDFRQRYRILNPAAIPEGQF 735
Cdd:cd14937   530 NNIISYLKSTNIYFIKCIKPNENKEKNNFNQKKVFPQLFSLSIIETLNI-SFFFQYKYTFDVFLSYFEYLDYSTSKDSSL 608

                         650       660       670
                  ....*....|....*....|....*....|.
gi 119586555  736 IDSRKGAEKLLSSLDIDhnQYKFGHTKVFFK 766
Cdd:cd14937   609 TDKEKVSMILQNTVDPD--LYKVGKTMVFLK 637
MYSc_Myo17 cd14879
class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase ...
 105-765 8.60e-83

class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase uses its motor domain to tether its vesicular cargo to peripheral actin. It works in opposition to dynein, contributing to the retention of Mcs1 vesicles at the site of cell growth and increasing vesicle fusion necessary for polarized growth. Class 17 myosins consist of a N-terminal myosin motor domain with Cyt-b5, chitin synthase 2, and a DEK_C domains at it C-terminus. The chitin synthase region contains several transmembrane domains by which myosin 17 is thought to bind secretory vesicles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276845 [Multi-domain]  Cd Length: 647  Bit Score: 286.75  E-value: 8.60e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  105 LKDRYGSWMIYTY---SGLfcVTVNPYKWLPVYTPEVVAAYR-------GKKRSEAPPHIFSISDNAYQYMLTDRENQSI 174
Cdd:cd14879    10 LASRFRSDLPYTRlgsSAL--VAVNPYKYLSSNSDASLGEYGseyydttSGSKEPLPPHAYDLAARAYLRMRRRSEDQAV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  175 LITGESGAGKTVNTKRVIQyfaviaAIGDRSKkdqSPGKGT-LEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFG 253
Cdd:cd14879    88 VFLGETGSGKSESRRLLLR------QLLRLSS---HSKKGTkLSSQISAAEFVLDSFGNAKTLTNPNASRFGRYTELQFN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  254 ATGKLASADIETYLLEKSRVIfQLKA-ERDYHIFYQILSNKKPELLDMLLItNNPYDYAFI--SQGETTVAS--IDDAEE 328
Cdd:cd14879   159 ERGRLIGAKVLDYRLERSRVA-SVPTgERNFHVFYYLLAGASPEERQHLGL-DDPSDYALLasYGCHPLPLGpgSDDAEG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  329 LMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFklkqreeQAEPDGTEEA---------DKSAYLMGLNSADLLKGL 399
Cdd:cd14879   237 FQELKTALKTLGFKRKHVAQICQLLAAILHLGNLEF-------TYDHEGGEESavvkntdvlDIVAAFLGVSPEDLETSL 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  400 CHPRVKVGNEYVTkgqnvqqvIY--ATGA------LAKAVYERMFNWMVTRINATL-ETKQPRQYFIGVLDIAGFEIFD- 469
Cdd:cd14879   310 TYKTKLVRKELCT--------VFldPEGAaaqrdeLARTLYSLLFAWVVETINQKLcAPEDDFATFISLLDFPGFQNRSs 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  470 --FNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLI-EKPMGIMSILEEEC-MFPKATD 545
Cdd:cd14879   382 tgGNSLDQFCVNFANERLHNYVLRSFFERKAEELEAEGVSVPATSY-FDNSDCVRLLrGKPGGLLGILDDQTrRMPKKTD 460

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  546 MTFKAKLfDNHLGKSANFQKPRNIKGKPEAH-FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLyqksslkLLSTLFANY 624
Cdd:cd14879   461 EQMLEAL-RKRFGNHSSFIAVGNFATRSGSAsFTVNHYAGEVTYSVEGFLERNGDVLSPDFVNL-------LRGATQLNA 532

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  625 AgadapiekgkgkakkgssfqtvsalhrenLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRI 704
Cdd:cd14879   533 A-----------------------------LSELLDTLDRTRLWSVFCIRPNDSQLPNSFDKRRVKAQIRSLGLPELAAR 583

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555  705 CRKGFPNRILYGDFRQRYrilnpaaIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFF 765
Cdd:cd14879   584 LRVEYVVSLEHAEFCERY-------KSTLRGSAAERIRQCARANGWWEGRDYVLGNTKVFL 637
MYSc_Myo23 cd14884
class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 ...
 99-714 9.79e-75

class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 IQ motifs and a single MyTH4 domain in its C-terminal tail. The lack of a FERM domain here is odd since MyTH4 domains are usually found alongside FERM domains where they bind to microtubules. At any rate these Class XXIII myosins are still proposed to function in the apicomplexan microtubule cytoskeleton. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276850 [Multi-domain]  Cd Length: 685  Bit Score: 264.46  E-value: 9.79e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEA-------PPHIFSISDNAYQYMLTDRE 170
Cdd:cd14884     1 PNVLQNLKNRYLKNKIYTFHASLLLALNPYKPLKeLYDQDVMNVYLHKKSNSAasaapfpKAHIYDIANMAYKNMRGKLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  171 NQSILITGESGAGKTVNTKRVIQYFAVIAaiGDRSKKDqspgkgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRI 250
Cdd:cd14884    81 RQTIVVSGHSGSGKTENCKFLFKYFHYIQ--TDSQMTE-------RIDKLIYINNILESMSNATTIKNNNSSRCGRINLL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  251 HF---------GATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGE---- 317
Cdd:cd14884   152 IFeeventqknMFNGCFRNIKIKILLLEINRCIAHNFGERNFHVFYQVLRGLSDEDLARRNLVRNCGVYGLLNPDEshqk 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  318 --------TTVASIDDAEELMATD--------NAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLkqreeqaepdgteea 381
Cdd:cd14884   232 rsvkgtlrLGSDSLDPSEEEKAKDeknfvallHGLHYIKYDERQINEFFDIIAGILHLGNRAYKA--------------- 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  382 dkSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINAT----------LETKQ 451
Cdd:cd14884   297 --AAECLQIEEEDLENVIKYKNIRVSHEVIRTERRKENATSTRDTLIKFIYKKLFNKIIEDINRNvlkckekdesDNEDI 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  452 PR--QYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDF--GMDLQACIDLIEKP 527
Cdd:cd14884   375 YSinEAIISILDIYGFEELSGNDFDQLCINLANEKLNNYYINNEIEKEKRIYARENIICCSDVApsYSDTLIFIAKIFRR 454

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  528 MGIMSILEEECMfpKATDMTFKAKLFDN----HLGK--SANFQKPRNIKGKPEAH------FSLIHYAGIVDYNIIGWLQ 595
Cdd:cd14884   455 LDDITKLKNQGQ--KKTDDHFFRYLLNNerqqQLEGkvSYGFVLNHDADGTAKKQnikkniFFIRHYAGLVTYRINNWID 532

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  596 KNKDPLNETVVGLYQKSSLKLLStlfanyagadapiekGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIP 675
Cdd:cd14884   533 KNSDKIETSIETLISCSSNRFLR---------------EANNGGNKGNFLSVSKKYIKELDNLFTQLQSTDMYYIRCFLP 597

                         650       660       670
                  ....*....|....*....|....*....|....*....
gi 119586555  676 NETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRIL 714
Cdd:cd14884   598 NAKMLPNTFKRLLVYRQLKQCGSNEMIKILNRGLSHKIP 636
MYSc_Myo12 cd14874
class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They ...
 100-766 1.67e-70

class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They are found predominately in nematodes. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276841 [Multi-domain]  Cd Length: 628  Bit Score: 250.17  E-value: 1.67e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYrgkkrseappHIFSISDNAYQYMLTDREN-QSILITG 178
Cdd:cd14874     2 GIAQNLHERFKKGQTYTKASNVLVFVNDFNKLSIQDQLVIKKC----------HISGVAENALDRIKSMSSNaESIVFGG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  179 ESGAGKTVNTKRVIQYFAviaaigdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14874    72 ESGSGKSYNAFQVFKYLT------------SQPKSKVTTKHSSAIESVFKSFGCAKTLKNDEATRFGCSIDLLYKRNVLT 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNpYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14874   140 GLNLKYTVPLEVPRVISQKPGERNFNVFYEVYHGLNDEMKAKFGIKGL-QKFFYINQGNSTENIQSDVNHFKHLEDALHV 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQ----REEQAEPDGTEEADKSAYLMGLNSADLLKGLChPRVKVGNEYvtkg 414
Cdd:cd14874   219 LGFSDDHCISIYKIISTILHIGNIYFRTKRnpnvEQDVVEIGNMSEVKWVAFLLEVDFDQLVNFLL-PKSEDGTTI---- 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  415 qNVQQVIYATGALAKAVYERMFNWMVTRINatLETKQPRQY-FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHM 493
Cdd:cd14874   294 -DLNAALDNRDSFAMLIYEELFKWVLNRIG--LHLKCPLHTgVISILDHYGFEKYNNNGVEEFLINSVNERIENLFVKHS 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  494 FVLEQEEYKKEGIEwtfIDFGMdlQACID-------LIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSAnFQKP 566
Cdd:cd14874   371 FHDQLVDYAKDGIS---VDYKV--PNSIEngktvelLFKKPYGLLPLLTDECKFPKGSHESYLEHCNLNHTDRSS-YGKA 444

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  567 RNikgKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQT 646
Cdd:cd14874   445 RN---KERLEFGVRHCIGTTWYNVTDFFSRNKRIISLSAVQLLRSSKNPIIGLLFESYSSNTSDMIVSQAQFILRGAQEI 521

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  647 VsalhrENLNKlmtnlrsTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 726
Cdd:cd14874   522 A-----DKING-------SHAHFVRCIKSNNERQPKKFDIPLVNRQIKNLLLAELLSFRIKGYPVKISKTTFARQYRCLL 589

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|.
gi 119586555  727 PAAIPEGQfiDSRKGAEKLLSSLDIDH-NQYKFGHTKVFFK 766
Cdd:cd14874   590 PGDIAMCQ--NEKEIIQDILQGQGVKYeNDFKIGTEYVFLR 628
MYSc_Myo20 cd14881
class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such ...
 100-746 7.27e-70

class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such members as Drosophila, Daphnia, and mosquitoes. These myosins contain a single IQ motif in the neck region. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276847 [Multi-domain]  Cd Length: 633  Bit Score: 248.49  E-value: 7.27e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPvyTPEVVAAYRGKKRSeapPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14881     2 AVMKCLQARFYAKEFFTNVGPILLSVNPYRDVG--NPLTLTSTRSSPLA---PQLLKVVQEAVRQQSETGYPQAIILSGT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  180 SGAGKTVNTKRVI-QYFAVIaaigdrskkdqspGKGTLED---QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgAT 255
Cdd:cd14881    77 SGSGKTYASMLLLrQLFDVA-------------GGGPETDafkHLAAAFTVLRSLGSAKTATNSESSRIGHFIEVQV-TD 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  256 GKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITN-NPYDYAFISQGETTVASIDDAEELMATDN 334
Cdd:cd14881   143 GALYRTKIHCYFLDQTRVIRPLPGEKNYHIFYQMLAGLSQEERVKLHLDGySPANLRYLSHGDTRQNEAEDAARFQAWKA 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  335 AFDVLG--FTSeeknsMYKLTGAIMHFGNMKFkLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGL---CHprvkvgne 409
Cdd:cd14881   223 CLGILGipFLD-----VVRVLAAVLLLGNVQF-IDGGGLEVDVKGETELKSVAALLGVSGAALFRGLttrTH-------- 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  410 yVTKGQNVQQVIYAT------GALAKAVYERMFNWMVTRIN------ATLETKQpRQYFIGVLDIAGFEIFDFNSFEQLC 477
Cdd:cd14881   289 -NARGQLVKSVCDANmsnmtrDALAKALYCRTVATIVRRANslkrlgSTLGTHA-TDGFIGILDMFGFEDPKPSQLEHLC 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  478 INFTNEKLQQFFNHHMFVLEQEEYKKEGIewtfidfGMDLQA-------CIDLIEK-PMGIMSILEEECMfPKATDMTFK 549
Cdd:cd14881   367 INLCAETMQHFYNTHIFKSSIESCRDEGI-------QCEVEVdyvdnvpCIDLISSlRTGLLSMLDVECS-PRGTAESYV 438

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  550 AKLfdnhlgKSANFQKPRNIKGKPEA--HFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLkllSTLFANYAga 627
Cdd:cd14881   439 AKI------KVQHRQNPRLFEAKPQDdrMFGIRHFAGRVVYDASDFLDTNRDVVPDDLVAVFYKQNC---NFGFATHT-- 507

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  628 dapiekgkgkakkgSSFQTvsalhreNLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRK 707
Cdd:cd14881   508 --------------QDFHT-------RLDNLLRTLVHARPHFVRCIRSNTTETPNHFDRGTVVRQIRSLQVLETVNLMAG 566

                         650       660       670
                  ....*....|....*....|....*....|....*....
gi 119586555  708 GFPNRILYGDFRQRYRILNPAAiPEGQFIDSRKGAEKLL 746
Cdd:cd14881   567 GYPHRMRFKAFNARYRLLAPFR-LLRRVEEKALEDCALI 604
MYSc_Myo44 cd14905
class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV ...
 105-718 1.41e-65

class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV class. Members here include cellular slime mold Polysphondylium and soil-living amoeba Dictyostelium. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276870  Cd Length: 673  Bit Score: 236.91  E-value: 1.41e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  105 LKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYrgKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAG 183
Cdd:cd14905     7 IQARYKKEIIYTYIGPILVSVNPLRYLPfLHSQELVRNY--NQRRGLPPHLFALAAKAISDMQDFRRDQLIFIGGESGSG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  184 KTVNTKRVIQYfaVIAAIGDRSKkdqspgkgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADI 263
Cdd:cd14905    85 KSENTKIIIQY--LLTTDLSRSK--------YLRDYILESGIILESFGHASTDSNHNSSRWGKYFEMFYSLYGEIQGAKL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  264 ETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITN-NPYDYafISQGET-TVASIDDAEELMATDNAFDVLGF 341
Cdd:cd14905   155 YSYFLDENRVTYQNKGERNFHIFYQFLKGITDEEKAAYQLGDiNSYHY--LNQGGSiSVESIDDNRVFDRLKMSFVFFDF 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  342 TSEEKNSMYKLTGAIMHFGNMKFKLKQREeqaepdgTEEADKSaylmglnsadLLKGLCH----PRVKVGNEYVT-KGQN 416
Cdd:cd14905   233 PSEKIDLIFKTLSFIIILGNVTFFQKNGK-------TEVKDRT----------LIESLSHnitfDSTKLENILISdRSMP 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  417 VQQVIYATGALAKAVYERMFNWMVTRINATLetkQPRQY--FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 494
Cdd:cd14905   296 VNEAVENRDSLARSLYSALFHWIIDFLNSKL---KPTQYshTLGILDLFGQESSQLNGYEQFSINFLEERLQQIYLQTVL 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  495 VLEQEEYKKEGIEW-TFIDFgMDLQACIDLIEKpmgIMSILEEECMFPKATDMTFKAKLfdnhlgksANFQKPRNIKGKP 573
Cdd:cd14905   373 KQEQREYQTERIPWmTPISF-KDNEESVEMMEK---IINLLDQESKNINSSDQIFLEKL--------QNFLSRHHLFGKK 440

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  574 EAHFSLIHYAGIVDYNIIGWLQKNKDP-------------------------LNETVVGLYQ---------KSSLKLLST 619
Cdd:cd14905   441 PNKFGIEHYFGQFYYDVRGFIIKNRDEilqrtnvlhknsitkylfsrdgvfnINATVAELNQmfdakntakKSPLSIVKV 520

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  620 LFA--------------NYAGADAPIEKGKGKAKKGSSFQTVSAlhrenLNKLMTNlRSTHPHFVRCIIPNETKSPGVMD 685
Cdd:cd14905   521 LLScgsnnpnnvnnpnnNSGGGGGGGNSGGGSGSGGSTYTTYSS-----TNKAINN-SNCDFHFIRCIKPNSKKTHLTFD 594

                         650       660       670
                  ....*....|....*....|....*....|....*..
gi 119586555  686 NPLVMHQLRCNGVLEGIRICRKGFP----NRILYGDF 718
Cdd:cd14905   595 VKSVNEQIKSLCLLETTRIQRFGYTihynNKIFFDRF 631
MYSc_Myo32 cd14893
class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but ...
 102-765 1.55e-65

class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but possess tandem MyTH4 and FERM domains. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276858  Cd Length: 741  Bit Score: 238.33  E-value: 1.55e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  102 LYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKR----------SEAPPHIFSISDNAYQYMLTDREN 171
Cdd:cd14893     4 LYTLRARYRMEQVYTWVDRVLVGVNPVTPLPIYTPDHMQAYNKSREqtplyekdtvNDAPPHVFALAQNALRCMQDAGED 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  172 QSILITGESGAGKTVNTKRVIQYfavIAAIGDRS--KKDQSPGKGTLE---DQIIQANPALEAFGNAKTVRNDNSSRFGK 246
Cdd:cd14893    84 QAVILLGGMGAGKSEAAKLIVQY---LCEIGDETepRPDSEGASGVLHpigQQILHAFTILEAFGNAATRQNRNSSRFAK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  247 FIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKK--PELLDMLLITNNPYDYAFISQG--ETTVAS 322
Cdd:cd14893   161 MISVEFSKHGHVIGGGFTTHYFEKSRVIDCRSHERNFHVFYQVLAGVQhdPTLRDSLEMNKCVNEFVMLKQAdpLATNFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  323 ID--DAEELMATdnaFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLN-------SA 393
Cdd:cd14893   241 LDarDYRDLMSS---FSALRIRKNQRVEIVRIVAALLHLGNVDFVPDPEGGKSVGGANSTTVSDAQSCALKdpaqillAA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  394 DLLKglCHPRV------------KVGNEYVT--KGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPR------ 453
Cdd:cd14893   318 KLLE--VEPVVldnyfrtrqffsKDGNKTVSslKVVTVHQARKARDTFVRSLYESLFNFLVETLNGILGGIFDRyeksni 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  454 ---QYFIGVLDIAGFEIFD--FNSFEQLCINFTNEKLQQFFNHHMFV-----LEQEEYKKEG--IEWTFIDFGMDLQACI 521
Cdd:cd14893   396 vinSQGVHVLDMVGFENLTpsQNSFDQLCFNYWSEKVHHFYVQNTLAinfsfLEDESQQVENrlTVNSNVDITSEQEKCL 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  522 DLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNH-----LGKSANFQKPRNIKGKPEAHFSLI----HYAGIVDYNII 591
Cdd:cd14893   476 QLFEdKPFGIFDLLTENCKVRLPNDEDFVNKLFSGNeavggLSRPNMGADTTNEYLAPSKDWRLLfivqHHCGKVTYNGK 555

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  592 GWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY---AGADAPIEKGKGKAKKGSSFQTVSALHRENLN------------ 656
Cdd:cd14893   556 GLSSKNMLSISSTCAAIMQSSKNAVLHAVGAAQmaaASSEKAAKQTEERGSTSSKFRKSASSARESKNitdsaatdvynq 635

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  657 --KLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRilnpaaipegQ 734
Cdd:cd14893   636 adALLHALNHTGKNFLVCIKPNETLEEGVFDSAYVMKQIRMNHLVELMQASRSIFTVHLTYGHFFRRYK----------N 705

                         730       740       750
                  ....*....|....*....|....*....|....*
gi 119586555  735 FIDSRKGAEKLLSSLD----IDHNQYKFGHTKVFF 765
Cdd:cd14893   706 VCGHRGTLESLLRSLSaigvLEEEKFVVGKTKVYL 740
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
 121-250 3.93e-62

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 209.89  E-value: 3.93e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  121 FCVTVNPYKWLPVYTPEVV-AAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIA 199
Cdd:cd01363     1 VLVRVNPFKELPIYRDSKIiVFYRGFRRSESQPHVFAIADPAYQSMLDGYNNQSIFAYGESGAGKTETMKGVIPYLASVA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555  200 AIGDRSKKDQ-----SPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRI 250
Cdd:cd01363    81 FNGINKGETEgwvylTEITVTLEDQILQANPILEAFGNAKTTRNENSSRFGKFIEI 136
MYSc_Myo21 cd14882
class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class ...
 101-725 2.04e-61

class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class XXI myosins do not group with them. Myo21, unlike other myosin proteins, contains UBA-like protein domains and has no structural or functional relationship with the myosins present in other organisms possessing cilia or flagella. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They have diverse tails with IQ, WW, PX, and Tub domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276848  Cd Length: 642  Bit Score: 223.85  E-value: 2.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd14882     3 ILEELRHRYLMGESYTFIGDILLSLNPNEIKQEYPQEFHAKYRCKSRSDNAPHIFSVADSAYQDMLHHEEPQHIILSGES 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  181 GAGKTVNTKRVIQYFAViaaIGDrskkdqspGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLAS 260
Cdd:cd14882    83 YSGKTTNARLLIKHLCY---LGD--------GNRGATGRVESSIKAILALVNAGTPLNADSTRCILQYQLTFGSTGKMSG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  261 ADIETYLLEKSRVIFQLKAERDYHIFYQILS--NKKPELLDMLLITNNPYDYAFISQG-------------ETTVASIDD 325
Cdd:cd14882   152 AIFWMYQLEKLRVSTTDGNQSNFHIFYYFYDfiEAQNRLKEYNLKAGRNYRYLRIPPEvppsklkyrrddpEGNVERYKE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  326 AEELmatdnaFDVLGFTSEEKNSMYKLTGAIMHFGNMKFklKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVK 405
Cdd:cd14882   232 FEEI------LKDLDFNEEQLETVRKVLAAILNLGEIRF--RQNGGYAELENTEIASRVAELLRLDEKKFMWALTNYCLI 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  406 VGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETkqPR-----QYFIGVLDIAGFEIFDFNSFEQLCINF 480
Cdd:cd14882   304 KGGSAERRKHTTEEARDARDVLASTLYSRLVDWIINRINMKMSF--PRavfgdKYSISIHDMFGFECFHRNRLEQLMVNT 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  481 TNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEecmfpKATDMTFKAKLFDNHLGKS 560
Cdd:cd14882   382 LNEQMQYHYNQRIFISEMLEMEEEDIPTINLRFYDNKTAVDQLMTKPDGLFYIIDD-----ASRSCQDQNYIMDRIKEKH 456

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  561 ANFQKPRNikgkpeAH-FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANyagadapiekgkgkaK 639
Cdd:cd14882   457 SQFVKKHS------AHeFSVAHYTGRIIYDAREFADKNRDFVPPEMIETMRSSLDESVKLMFTN---------------S 515

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  640 KGSSFQTVSALHR----ENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILY 715
Cdd:cd14882   516 QVRNMRTLAATFRatslELLKMLSIGANSGGTHFVRCIRSDLEYKPRGFHSEVVRQQMRALAVLDTAKARQKGFSYRIPF 595

                         650
                  ....*....|
gi 119586555  716 GDFRQRYRIL 725
Cdd:cd14882   596 QEFLRRYQFL 605
MYSc_Myo24B cd14938
class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
 99-764 1.70e-44

class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The functions of these myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276898 [Multi-domain]  Cd Length: 713  Bit Score: 174.25  E-value: 1.70e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSE-APPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14938     1 PSVLYHLKERFKNNKFYTKMGPLLIFINPKINNNINNEETIEKYKCIDCIEdLSLNEYHVVHNALKNLNELKRNQSIIIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  178 GESGAGKTVNTKRVIQYFAViAAIGDRSKKDQS--------------PGKGTLEDQIIQANPALEAFGNAKTVRNDNSSR 243
Cdd:cd14938    81 GESGSGKSEIAKNIINFIAY-QVKGSRRLPTNLndqeednihneentDYQFNMSEMLKHVNVVMEAFGNAKTVKNNNSSR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  244 FGKFIRIHFgATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYdYAFISQGETTVASI 323
Cdd:cd14938   160 FSKFCTIHI-ENEEIKSFHIKKFLLDKERLINRKANENSFNIFYYIINGSSDKFKKMYFLKNIEN-YSMLNNEKGFEKFS 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  324 DDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGN-------------MKFKLKQRE----------EQAEPDGTEE 380
Cdd:cd14938   238 DYSGKILELLKSLNYIFDDDKEIDFIFSVLSALLLLGNteivkafrkksllMGKNQCGQNinyetilselENSEDIGLDE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  381 ADKSAYL----MGLNSADLLKGLCHPRVkVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYF 456
Cdd:cd14938   318 NVKNLLLacklLSFDIETFVKYFTTNYI-FNDSILIKVHNETKIQKKLENFIKTCYEELFNWIIYKINEKCTQLQNININ 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  457 ---IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM--GIM 531
Cdd:cd14938   397 tnyINVLDMAYFENSKDNSLEQLLINTTNEEIIKIKNDCLYKKRVLSYNEDGIFCEYNSENIDNEPLYNLLVGPTegSLF 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  532 SILEEECMfPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAhFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQK 611
Cdd:cd14938   477 SLLENVST-KTIFDKSNLHSSIIRKFSRNSKYIKKDDITGNKKT-FVITHSCGDIIYNAENFVEKNIDILTNRFIDMVKQ 554

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  612 SSLKLLSTL--FANYAGADAPIEKGKG----------KAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETK 679
Cdd:cd14938   555 SENEYMRQFcmFYNYDNSGNIVEEKRRysiqsalklfKRRYDTKNQMAVSLLRNNLTELEKLQETTFCHFIVCMKPNESK 634

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  680 SP-GVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPaaipegqfiDSRKGAEKLLSSLDIDHNQYKF 758
Cdd:cd14938   635 RElCSFDANIVLRQVRNFSIVEASQLKVGYYPHKFTLNEFLSIFDIKNE---------DLKEKVEALIKSYQISNYEWMI 705


                  ....*.
gi 119586555  759 GHTKVF 764
Cdd:cd14938   706 GNNMIF 711
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1173-1931 4.83e-32

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 137.11  E-value: 4.83e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1173 KMRRdlEEATLQHEATAAALrKKHADSVAELGEQIDNLQRVKQK----LEKEKSEFKLELDDVTSNMEQiIKAKAANLEK 1248
Cdd:TIGR02168  171 KERR--KETERKLERTRENL-DRLEDILNELERQLKSLERQAEKaeryKELKAELRELELALLVLRLEE-LREELEELQE 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1249 MCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEevkAKN 1328
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEE---LEA 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1329 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRtkyetDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1408
Cdd:TIGR02168  324 QLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELE-----ELESRLEELEEQLETLRSKVAQLELQIASL 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1409 NAKCSSLEKTKHRLQNEIEDLMVDVE--RSNAAAAALDKKQRNF---DKILAEWKQKYEESQSELESSQKEARSLSTELF 1483
Cdd:TIGR02168  399 NNEIERLEARLERLEDRRERLQQEIEelLKKLEEAELKELQAELeelEEELEELQEELERLEEALEELREELEEAEQALD 478

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1484 KLKN----------AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA---EKME------LQSA 1544
Cdd:TIGR02168  479 AAERelaqlqarldSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAalgGRLQavvvenLNAA 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1545 LEEAEASLEHEEGK--------ILRAQLEFN--QIKAEIERKLAEKDEEMEQAKR---------NHLRVVDSLQTSLDAE 1605
Cdd:TIGR02168  559 KKAIAFLKQNELGRvtflpldsIKGTEIQGNdrEILKNIEGFLGVAKDLVKFDPKlrkalsyllGGVLVVDDLDNALELA 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1606 TRSRNEALRVKKkmEGDL-----------NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1674
Cdd:TIGR02168  639 KKLRPGYRIVTL--DGDLvrpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQ 716

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1675 V-------ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ 1747
Cdd:TIGR02168  717 LrkeleelSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKE 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1748 ECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKgGKKQLQKLEARVRELENEL 1827
Cdd:TIGR02168  797 ELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIES-LAAEIEELEELIEELESEL 875

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1828 EAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR-KVQHELDE 1906
Cdd:TIGR02168  876 EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSeEYSLTLEE 955

                          810       820
                   ....*....|....*....|....*
gi 119586555  1907 AEERADIAESQVNKLRAKSRDIGTK 1931
Cdd:TIGR02168  956 AEALENKIEDDEEEARRRLKRLENK 980
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 840-1673 3.99e-30

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 130.95  E-value: 3.99e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKV 919
Cdd:TIGR02168  218 LKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEI 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   920 KEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 999
Cdd:TIGR02168  298 SRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEEL 377

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1000 QEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLEraKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Cdd:TIGR02168  378 EEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELL--KKLEEAELKELQAELEELEEELEELQEE 455

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT---ARAKVEKLRSDLSRELEEISER------- 1149
Cdd:TIGR02168  456 LERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfseGVKALLKNQSGLSGILGVLSELisvdegy 535

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1150 ---LEEAGGATSVQIEMNKKREAefqkmrRDLEEATLQHEATAAAL----RKKHADSVAELGEQIDNLQRVKQ---KLEK 1219
Cdd:TIGR02168  536 eaaIEAALGGRLQAVVVENLNAA------KKAIAFLKQNELGRVTFlpldSIKGTEIQGNDREILKNIEGFLGvakDLVK 609

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1220 EKSEFKLELDD------VTSNMEQII-KAKAANLEKMCRTLEDQM-----------NEHRSKAEETQRSVNDLTSQRAKL 1281
Cdd:TIGR02168  610 FDPKLRKALSYllggvlVVDDLDNALeLAKKLRPGYRIVTLDGDLvrpggvitggsAKTNSSILERRREIEELEEKIEEL 689

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1282 QTENGELSRQLDEKEALISQLtrgkltyTQQLEDLKRQLEEEVKAKNALAHALQSArhdcdllreqyEEETEAKAELQRV 1361
Cdd:TIGR02168  690 EEKIAELEKALAELRKELEEL-------EEELEQLRKELEELSRQISALRKDLARL-----------EAEVEQLEERIAQ 751

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1362 LSKANSEVAQWRTKYEtdaiQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLmvdversNAAAA 1441
Cdd:TIGR02168  752 LSKELTELEAEIEELE----ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL-------NEEAA 820

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1442 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSG 1521
Cdd:TIGR02168  821 NLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELS 900

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1522 KTIHELEKVRKQLEAEKMELQSALEEAEASLEheegkilRAQLEFNQIKAeierKLAEKDE-EMEQAKRNHLRVVDSLQt 1600
Cdd:TIGR02168  901 EELRELESKRSELRRELEELREKLAQLELRLE-------GLEVRIDNLQE----RLSEEYSlTLEEAEALENKIEDDEE- 968

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119586555  1601 sldaETRSRNEALRVKKKMEGDLNEMEIQlshanrmaaEAQKQVKSLQSLLKdtqiQLDDAVRANDDLKENIA 1673
Cdd:TIGR02168  969 ----EARRRLKRLENKIKELGPVNLAAIE---------EYEELKERYDFLTA----QKEDLTEAKETLEEAIE 1024
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 942-1872 9.95e-29

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 126.32  E-value: 9.95e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   942 KLEDECSELKRDIDDLELTLAKVEkekhatenKVKNLTEEMAGLDeiIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Cdd:TIGR02168  190 RLEDILNELERQLKSLERQAEKAE--------RYKELKAELRELE--LALLVLRLEELREELEELQEELKEAEEELEELT 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1022 KAKVKLEQQVDDLEGSLEQekkvrmdLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEdeqalg 1101
Cdd:TIGR02168  260 AELQELEEKLEELRLEVSE-------LEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLE------ 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1102 sQLQKKLKELQARIeeleeeleaertarAKVEKLRSDLSRELEEISERLEEAGGatsvQIEMNKKREAEFQKMRRDLEEA 1181
Cdd:TIGR02168  327 -ELESKLDELAEEL--------------AELEEKLEELKEELESLEAELEELEA----ELEELESRLEELEEQLETLRSK 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1182 TLQHEATAAALRKKhadsVAELGEQIDNLQRVKQKLEKEKSEFKLELDdvtsnmeqiikakaanlekmcrtlEDQMNEHR 1261
Cdd:TIGR02168  388 VAQLELQIASLNNE----IERLEARLERLEDRRERLQQEIEELLKKLE------------------------EAELKELQ 439

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1262 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK----AKNALAHALQSA 1337
Cdd:TIGR02168  440 AELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfsegVKALLKNQSGLS 519

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1338 RHDcDLLREQYEEETEAKAELQRVLSKANSEVAqwrTKYETDAIQRTEELEEAKK--------------KLAQRLQEAEE 1403
Cdd:TIGR02168  520 GIL-GVLSELISVDEGYEAAIEAALGGRLQAVV---VENLNAAKKAIAFLKQNELgrvtflpldsikgtEIQGNDREILK 595

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1404 AVEAVNAKCSSLEKTKHRLQNEIEDL-----MVD-VERSNAAAAALDKKQRNF----DKILAEWkqkyeesqseleSSQK 1473
Cdd:TIGR02168  596 NIEGFLGVAKDLVKFDPKLRKALSYLlggvlVVDdLDNALELAKKLRPGYRIVtldgDLVRPGG------------VITG 663

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1474 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLgssgktiHELEKVRKQLEAEKMELQSALEEAEASLE 1553
Cdd:TIGR02168  664 GSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKEL-------EELEEELEQLRKELEELSRQISALRKDLA 736

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1554 HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQakrnhlrvvdslqtsLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1633
Cdd:TIGR02168  737 RLEAEVEQLEERIAQLSKELTELEAEIEELEER---------------LEEAEEELAEAEAEIEELEAQIEQLKEELKAL 801

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1634 NRMAAEAQKQvkslqslLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKlAEQELIETser 1713
Cdd:TIGR02168  802 REALDELRAE-------LTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIE-ELEELIEE--- 870

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1714 vqlLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQdtsAHLERMKKNMEQTIKD 1793
Cdd:TIGR02168  871 ---LESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE---LRLEGLEVRIDNLQER 944

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1794 L--QHRLDEAEQIALK-GGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVD 1870
Cdd:TIGR02168  945 LseEYSLTLEEAEALEnKIEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEELKERYDFLTAQKEDLTEAKETLEEAIE 1024


                   ..
gi 119586555  1871 KL 1872
Cdd:TIGR02168 1025 EI 1026
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1312-1937 5.31e-27

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 120.55  E-value: 5.31e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1312 QLEDLKRQLEeevKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEvaqwRTKYETDAIQRTEELEEAK 1391
Cdd:TIGR02168  201 QLKSLERQAE---KAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEE----LEELTAELQELEEKLEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1392 KK---LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL 1468
Cdd:TIGR02168  274 LEvseLEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEEL 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1469 ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA 1548
Cdd:TIGR02168  354 ESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1549 EASLEHEEGKILRAQLE--------FNQIKAEIERKLAEKDEEMEQAKRNH------LRVVDSLQTSLDAETRSRNEALR 1614
Cdd:TIGR02168  434 ELKELQAELEELEEELEelqeelerLEEALEELREELEEAEQALDAAERELaqlqarLDSLERLQENLEGFSEGVKALLK 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1615 VKKKMEGDLN--------------EMEIQL-----------SHANRMAAEAQKQVKS------LQSLLKDTQIQLDDAVR 1663
Cdd:TIGR02168  514 NQSGLSGILGvlselisvdegyeaAIEAALggrlqavvvenLNAAKKAIAFLKQNELgrvtflPLDSIKGTEIQGNDREI 593

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1664 AN---------------------------------DDLKENIAI----------------------------VERRNNLL 1682
Cdd:TIGR02168  594 LKniegflgvakdlvkfdpklrkalsyllggvlvvDDLDNALELakklrpgyrivtldgdlvrpggvitggsAKTNSSIL 673

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1683 --QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK---AK 1757
Cdd:TIGR02168  674 erRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERiaqLS 753

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1758 KAITDA----AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELENELEAEQKR 1833
Cdd:TIGR02168  754 KELTELeaeiEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALRE-ALDELRAELTLLNEEAANLRERLESLERR 832

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1834 NAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1913
Cdd:TIGR02168  833 IAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSE 912

                          730       740
                   ....*....|....*....|....
gi 119586555  1914 AESQVNKLRAKSRDIGTKRCGFTM 1937
Cdd:TIGR02168  913 LRRELEELREKLAQLELRLEGLEV 936
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 833-1453 2.06e-26

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 118.50  E-value: 2.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  833 YFKIKPLLKSAERE---KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Cdd:COG1196   215 YRELKEELKELEAElllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989
Cdd:COG1196   295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  990 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069
Cdd:COG1196   375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK---------VEKLRSDLS 1140
Cdd:COG1196   455 EEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLaglrglagaVAVLIGVEA 534

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1141 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
Cdd:COG1196   535 AYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADAR 614

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1221 KSEFKLELDDVTSNMEQIIKAKAanlekmcrtledQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALIS 1300
Cdd:COG1196   615 YYVLGDTLLGRTLVAARLEAALR------------RAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELE 682

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1301 QLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAqwrtKYETDA 1380
Cdd:COG1196   683 ELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA----LEELPE 758

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1381 IQRTEELEEAKKKLAQRLQE-------AEEAVEAVNAKCSSLEKTKHRLQNEIEDLM-----VDVERSNAAAAALDKKQR 1448
Cdd:COG1196   759 PPDLEELERELERLEREIEAlgpvnllAIEEYEELEERYDFLSEQREDLEEARETLEeaieeIDRETRERFLETFDAVNE 838


                  ....*
gi 119586555 1449 NFDKI 1453
Cdd:COG1196   839 NFQEL 843
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 963-1857 4.86e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 114.00  E-value: 4.86e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   963 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD--DLQAEEDKVNtLTKAKVKLEQQVDDLEGSLEQ 1040
Cdd:TIGR02168  169 KYKERRKETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERykELKAELRELE-LALLVLRLEELREELEELQEE 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1041 EKKvrmdLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDeqalgsqLQKKLKELQARIEELEE 1120
Cdd:TIGR02168  248 LKE----AEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISR-------LEQQKQILRERLANLER 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1121 ELEAERTARAKVEKLRSDLSRELEEISERLEEAggatSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKhadsV 1200
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAELEEKLEEL----KEELESLEAELEELEAELEELESRLEELEEQLETLRSK----V 388

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1201 AELGEQIDNLQRVKQKLEKEKSEFKLELDdvtsNMEQIIKAKAANLEkmcrtlEDQMNEHRSKAEETQRSVNDLTSQRAK 1280
Cdd:TIGR02168  389 AQLELQIASLNNEIERLEARLERLEDRRE----RLQQEIEELLKKLE------EAELKELQAELEELEEELEELQEELER 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1281 LQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK----AKNALAHALQSARHDcDLLREQYEEETEAKA 1356
Cdd:TIGR02168  459 LEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfsegVKALLKNQSGLSGIL-GVLSELISVDEGYEA 537

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1357 ELQRVLSKANSEVAqwrTKYETDAIQRTEELEEAKK--------------KLAQRLQEAEEAVEAVNAKCSSLEKTKHRL 1422
Cdd:TIGR02168  538 AIEAALGGRLQAVV---VENLNAAKKAIAFLKQNELgrvtflpldsikgtEIQGNDREILKNIEGFLGVAKDLVKFDPKL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1423 QNEIEDL-----MVD-VERSNAAAAALDKKQRNF----DKILAEWkqkyeesqseleSSQKEARSLSTELFKLKNAYEES 1492
Cdd:TIGR02168  615 RKALSYLlggvlVVDdLDNALELAKKLRPGYRIVtldgDLVRPGG------------VITGGSAKTNSSILERRREIEEL 682

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1493 LEHLETFKRENKNLQEEISDLTEQLgssgktiHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE 1572
Cdd:TIGR02168  683 EEKIEELEEKIAELEKALAELRKEL-------EELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKE 755

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1573 IERKLAEKDEEMEQakrnhlrvvdslqtsLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQvkslqslLK 1652
Cdd:TIGR02168  756 LTELEAEIEELEER---------------LEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAE-------LT 813

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1653 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKlAEQELIETservqlLHSQNTSLINQKKKMD 1732
Cdd:TIGR02168  814 LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIE-ELEELIEE------LESELEALLNERASLE 886

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1733 ADLSQLQTEVEEAVQECRNAEEKAKkaitdaammaeelkkeqdtsahlermkknmeqtikDLQHRLDEAEQiALKGGKKQ 1812
Cdd:TIGR02168  887 EALALLRSELEELSEELRELESKRS-----------------------------------ELRRELEELRE-KLAQLELR 930

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|...
gi 119586555  1813 LQKLEARVRELENELEAEQKRNAESVKGM--------RKSERRIKELTYQTEE 1857
Cdd:TIGR02168  931 LEGLEVRIDNLQERLSEEYSLTLEEAEALenkieddeEEARRRLKRLENKIKE 983
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 841-1534 1.50e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.46  E-value: 1.50e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920
Cdd:TIGR02168  268 KLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLE 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   921 EMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Cdd:TIGR02168  348 ELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELL 427

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1001 EAHQQAldDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER- 1079
Cdd:TIGR02168  428 KKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFs 505

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1080 -----LKKKDFELNALNARIED------------EQALGSQLQK----------------------KLKELQARIEELEE 1120
Cdd:TIGR02168  506 egvkaLLKNQSGLSGILGVLSElisvdegyeaaiEAALGGRLQAvvvenlnaakkaiaflkqnelgRVTFLPLDSIKGTE 585

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1121 ELEAERTARAKVEKLRSDLSrELEEISERLEEAGG--------ATSVQIEMNKKREAEFQKM------------------ 1174
Cdd:TIGR02168  586 IQGNDREILKNIEGFLGVAK-DLVKFDPKLRKALSyllggvlvVDDLDNALELAKKLRPGYRivtldgdlvrpggvitgg 664

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1175 RRDLEEATLQHEATAAALRKKhadsVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI------IKAKAANLEK 1248
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEK----IEELEEKIAELEKALAELRKELEELEEELEQLRKELEELsrqisaLRKDLARLEA 740

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1249 MCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN 1328
Cdd:TIGR02168  741 EVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAA 820

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1329 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETdAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1408
Cdd:TIGR02168  821 NLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE-LESELEALLNERASLEEALALLRSELEEL 899

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1409 NAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK-QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN 1487
Cdd:TIGR02168  900 SEELRELESKRSELRRELEELREKLAQLELRLEGLEVRiDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLEN 979

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....
gi 119586555  1488 AYEE----SLEHLETFKRENK---NLQEEISDLTEQLGSSGKTIHELEKVRKQL 1534
Cdd:TIGR02168  980 KIKElgpvNLAAIEEYEELKErydFLTAQKEDLTEAKETLEEAIEEIDREARER 1033
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 840-1701 1.54e-24

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 112.47  E-value: 1.54e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   840 LKSAEREKEMAsmkEEFTRLKEalEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKV 919
Cdd:TIGR02169  200 LERLRREREKA---ERYQALLK--EKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLL 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   920 KEMNERLEDE-EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 998
Cdd:TIGR02169  275 EELNKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDK 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   999 LQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDkqqlde 1078
Cdd:TIGR02169  355 LTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAA------ 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1079 rLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL----EEAG 1154
Cdd:TIGR02169  429 -IAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQAraseERVR 507

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1155 GATSVQIEMNKKREAEFQKMRrDLEEATLQHEA---TAAALRKKHA----DSVAElgEQIDNLQRVKQ------KLEKEK 1221
Cdd:TIGR02169  508 GGRAVEEVLKASIQGVHGTVA-QLGSVGERYATaieVAAGNRLNNVvvedDAVAK--EAIELLKRRKAgratflPLNKMR 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1222 SEFKleldDVTSNMEQIIKAKAANLekmcRTLEDQMNEHRSKAEETQRSVNDLTSQRA-----KLQTENGELSrqldEKE 1296
Cdd:TIGR02169  585 DERR----DLSILSEDGVIGFAVDL----VEFDPKYEPAFKYVFGDTLVVEDIEAARRlmgkyRMVTLEGELF----EKS 652

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1297 ALIS----QLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRvLSKANSEVAQw 1372
Cdd:TIGR02169  653 GAMTggsrAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGE-IEKEIEQLEQ- 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1373 rtkYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNaaaaaLDKKQRNFDK 1452
Cdd:TIGR02169  731 ---EEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSR-----IPEIQAELSK 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1453 IlaewkqkyeesqselessQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1532
Cdd:TIGR02169  803 L------------------EEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKE 864

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1533 QLEAEKMELQSALEEAEASLEHEEGKILRAQLEfnqiKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEA 1612
Cdd:TIGR02169  865 ELEEELEELEAALRDLESRLGDLKKERDELEAQ----LRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPK 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1613 LRVKKKMEGDLNEMEIQLshanrMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEniaiverRNNLLQAELEELRAV 1692
Cdd:TIGR02169  941 GEDEEIPEEELSLEDVQA-----ELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKE-------KRAKLEEERKAILER 1008


                   ....*....
gi 119586555  1693 VEQTERSRK 1701
Cdd:TIGR02169 1009 IEEYEKKKR 1017
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1311-1929 3.73e-24

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 111.18  E-value: 3.73e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1311 QQLEDLKRQ-----------LEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVaqwrtkyetd 1379
Cdd:COG1196   200 RQLEPLERQaekaeryrelkEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAEL---------- 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1380 aiqrtEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1459
Cdd:COG1196   270 -----EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEE 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1460 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM 1539
Cdd:COG1196   345 ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELE 424

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1540 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRsrneaLRVKKKM 1619
Cdd:COG1196   425 ELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAAR-----LLLLLEA 499

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1620 EGDlnemeiqlshanrmAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQaeleelRAVVEQTERS 1699
Cdd:COG1196   500 EAD--------------YEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQ------NIVVEDDEVA 559

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1700 RKLAEQELIETSERVQLLHSqntSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1779
Cdd:COG1196   560 AAAIEYLKAAKAGRATFLPL---DKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAAL 636

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1780 LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVkgmRKSERRIKELTYQTEEDR 1859
Cdd:COG1196   637 RRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELEL---EEALLAEEEEERELAEAE 713

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1860 KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSkfrKVQHELDEAEERADIAESQVNKLRAKSRDIG 1929
Cdd:COG1196   714 EERLEEELEEEALEEQLEAEREELLEELLEEEELLE---EEALEELPEPPDLEELERELERLEREIEALG 780
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1106-1910 1.25e-23

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 109.39  E-value: 1.25e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1106 KKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEaggatsVQIEMNKKReaEFQKMRRDLEEAtlqh 1185
Cdd:TIGR02169  156 RKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLER------LRREREKAE--RYQALLKEKREY---- 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1186 EATAAALRKKHADsvaelgEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKAE 1265
Cdd:TIGR02169  224 EGYELLKEKEALE------RQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIG 297

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1266 ETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRgkltytqQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR 1345
Cdd:TIGR02169  298 ELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLA-------EIEELEREIEEERKRRDKLTEEYAELKEELEDLR 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1346 EQYEEETEAKAELQRvlskansEVAQWRTKYEtDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1425
Cdd:TIGR02169  371 AELEEVDKEFAETRD-------ELKDYREKLE-KLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEE 442

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1426 IEDLMVDVErsnaaaaALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLknayEESLEHLETFKRENKN 1505
Cdd:TIGR02169  443 KEDKALEIK-------KQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEA----EAQARASEERVRGGRA 511

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1506 LQEEISDLTEqlGSSGkTIHELEKVRKQ------------LEAEKMELQSALEEAEASLEHEegKILRAQ-LEFNQIKAE 1572
Cdd:TIGR02169  512 VEEVLKASIQ--GVHG-TVAQLGSVGERyataievaagnrLNNVVVEDDAVAKEAIELLKRR--KAGRATfLPLNKMRDE 586

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1573 --------------IERKLAEKDEEMEQAKRNHLR---VVDSLQT-----------SLDAE-----------TRSRNEAL 1613
Cdd:TIGR02169  587 rrdlsilsedgvigFAVDLVEFDPKYEPAFKYVFGdtlVVEDIEAarrlmgkyrmvTLEGElfeksgamtggSRAPRGGI 666

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1614 RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVV 1693
Cdd:TIGR02169  667 LFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDL 746

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1694 EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSqlQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE 1773
Cdd:TIGR02169  747 SSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLS--HSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRL 824

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1774 QDTSAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKK-----QLQKLEARVRELENELEAEQKRNAESVKGMRKSERR 1847
Cdd:TIGR02169  825 TLEKEYLEKEIQELQEQRIDLKEQIKSiEKEIENLNGKKeeleeELEELEAALRDLESRLGDLKKERDELEAQLRELERK 904

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119586555  1848 IKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSkFRKVQHELDEAEER 1910
Cdd:TIGR02169  905 IEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELS-LEDVQAELQRVEEE 966
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 844-1579 7.07e-23

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 107.08  E-value: 7.07e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   844 EREKEMAsmKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND--------------------------------LQLQV 891
Cdd:TIGR02169  169 DRKKEKA--LEELEEVEENIERLDLIIDEKRQQLERLRREREKaeryqallkekreyegyellkekealerqkeaIERQL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   892 QAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLED--EEEMN------AELTAKKRKLEDECSELKRDIDDLELTLAK 963
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDlgEEEQLrvkekiGELEAEIASLERSIAEKERELEDAEERLAK 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   964 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043
Cdd:TIGR02169  327 LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKR 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1044 VRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE--------------LNALNARIEDEQALGSQLQKKLK 1109
Cdd:TIGR02169  407 ELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEikkqewkleqlaadLSKYEQELYDLKEEYDRVEKELS 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1110 ELQARIEELEEELEAERTA----RAKVEKLRSDLS------RELEEISER----LEEAGG----ATSVQIEMNKKREAEF 1171
Cdd:TIGR02169  487 KLQRELAEAEAQARASEERvrggRAVEEVLKASIQgvhgtvAQLGSVGERyataIEVAAGnrlnNVVVEDDAVAKEAIEL 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1172 QKmRRDLEEATLqheATAAALRKKHAD-SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDvTSNMEQIIKAKAANLEKMC 1250
Cdd:TIGR02169  567 LK-RRKAGRATF---LPLNKMRDERRDlSILSEDGVIGFAVDLVEFDPKYEPAFKYVFGD-TLVVEDIEAARRLMGKYRM 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1251 RTLEDQMNEhRSKA-----EETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGK---LTYTQQLEDLKRQLEE 1322
Cdd:TIGR02169  642 VTLEGELFE-KSGAmtggsRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIEnrlDELSQELSDASRKIGE 720

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1323 EVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQwrtkYETDAIQRTEELEEAKKKLAQrlqeae 1402
Cdd:TIGR02169  721 IEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEE----LEEDLHKLEEALNDLEARLSH------ 790

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1403 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1482
Cdd:TIGR02169  791 SRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEEL 870

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1483 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEgKILRA 1562
Cdd:TIGR02169  871 EELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDE-EIPEE 949

                          810
                   ....*....|....*..
gi 119586555  1563 QLEFNQIKAEIERKLAE 1579
Cdd:TIGR02169  950 ELSLEDVQAELQRVEEE 966
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1074-1730 2.02e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 105.40  E-value: 2.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1074 QQLDERLKKKD-----FELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE 1148
Cdd:COG1196   216 RELKEELKELEaelllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLA 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1149 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALrkkhadsvAELGEQIDNLQRVKQKLEKEKSEFKLEL 1228
Cdd:COG1196   296 ELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEEL--------EELEEELEEAEEELEEAEAELAEAEEAL 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1229 DDVTSNMEQIIKAKAANLEKMcRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTrgklt 1308
Cdd:COG1196   368 LEAEAELAEAEEELEELAEEL-LEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE----- 441

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1309 ytQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1388
Cdd:COG1196   442 --EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGL 519

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1389 EAKKKLAQRLQEAEEAVEAVnakcsslektkhrLQNEIEDLMVDVERSNAAAAAldkKQRNFDKILAEWKQKYEESQSEL 1468
Cdd:COG1196   520 RGLAGAVAVLIGVEAAYEAA-------------LEAALAAALQNIVVEDDEVAA---AAIEYLKAAKAGRATFLPLDKIR 583

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1469 ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA 1548
Cdd:COG1196   584 ARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLT 663

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1549 EASLEHEEGKILRAQlefnqikAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEI 1628
Cdd:COG1196   664 GGSRRELLAALLEAE-------AELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREE 736

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1629 QLShanrmaaeaqkqvkslqsLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEqtersrkLAEQELI 1708
Cdd:COG1196   737 LLE------------------ELLEEEELLEEEALEELPEPPDLEELERELERLEREIEALGPVNL-------LAIEEYE 791

                         650       660
                  ....*....|....*....|..
gi 119586555 1709 ETSERVQLLHSQNTSLINQKKK 1730
Cdd:COG1196   792 ELEERYDFLSEQREDLEEARET 813
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 978-1861 8.67e-21

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 100.14  E-value: 8.67e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   978 LTEEMAGLDEIIAKLTKEKKALQEAHQQaLDDLQAEEDKVNtltkakvkleQQVDDLEGslEQEKKVR-MDLERAKRKLE 1056
Cdd:TIGR02169  158 IIDEIAGVAEFDRKKEKALEELEEVEEN-IERLDLIIDEKR----------QQLERLRR--EREKAERyQALLKEKREYE 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1057 GDLKLTQesIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEaeRTARAKVEKLR 1136
Cdd:TIGR02169  225 GYELLKE--KEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQ--LRVKEKIGELE 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1137 SDLS---RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA---AALRKKHADSVAELGEQIDNL 1210
Cdd:TIGR02169  301 AEIAsleRSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTeeyAELKEELEDLRAELEEVDKEF 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1211 QRVKQKLekekSEFKLELDDVTSNMEQiikakaanLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR 1290
Cdd:TIGR02169  381 AETRDEL----KDYREKLEKLKREINE--------LKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKAL 448

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1291 QLDEKEALISQLTRGKLTYTQQLEDLK---RQLEEEV-KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAn 1366
Cdd:TIGR02169  449 EIKKQEWKLEQLAADLSKYEQELYDLKeeyDRVEKELsKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTV- 527

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1367 SEVAQWRTKYETdaiqrteELEEAkkkLAQRLQEAEEAVEAVNAKCSSLEKTKH--RLQ----NEIEDLMVDVERSNAAA 1440
Cdd:TIGR02169  528 AQLGSVGERYAT-------AIEVA---AGNRLNNVVVEDDAVAKEAIELLKRRKagRATflplNKMRDERRDLSILSEDG 597

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1441 AA--------LDKKQRN-----------FDKILAEWKQ-------------------------KYEESQSELESSQKEAR 1476
Cdd:TIGR02169  598 VIgfavdlveFDPKYEPafkyvfgdtlvVEDIEAARRLmgkyrmvtlegelfeksgamtggsrAPRGGILFSRSEPAELQ 677

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1477 SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVR-------KQLEAEKMELQSALEEAE 1549
Cdd:TIGR02169  678 RLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEeklkerlEELEEDLSSLEQEIENVK 757

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1550 ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDslqtsldaETRSRNEALrvkkkmegdLNEMEIQ 1629
Cdd:TIGR02169  758 SELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLE--------EEVSRIEAR---------LREIEQK 820

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1630 LSHANRMAAEAQKQVKSLQSLlkdtqiqlddavraNDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE 1709
Cdd:TIGR02169  821 LNRLTLEKEYLEKEIQELQEQ--------------RIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGD 886

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1710 TSErvqllhsqntslinQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKkeqdtsaHLERMKKNMEQ 1789
Cdd:TIGR02169  887 LKK--------------ERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELS-------EIEDPKGEDEE 945

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1790 tikdlqhrlDEAEQIALKGGKKQLQKLEARVRELE-------NELEAEQKRNAESVKGMRK--SERR-IKELTYQTEEDR 1859
Cdd:TIGR02169  946 ---------IPEEELSLEDVQAELQRVEEEIRALEpvnmlaiQEYEEVLKRLDELKEKRAKleEERKaILERIEEYEKKK 1016


                   ..
gi 119586555  1860 KN 1861
Cdd:TIGR02169 1017 RE 1018
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 841-1513 2.98e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 98.59  E-value: 2.98e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKM-------VSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI 913
Cdd:TIGR02168  345 KLEELKEELESLEAELEELEAELEELESRLEELEEQLetlrskvAQLELQIASLNNEIERLEARLERLEDRRERLQQEIE 424

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   914 QL-----EAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKV---KNLTEEMAGL 985
Cdd:TIGR02168  425 ELlkkleEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLdslERLQENLEGF 504

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   986 DEIIAKLTKEKKALQEAHQQALDDLQAEED---KVNT-----LTKAKVKLEQQVDDLEGSLEQEKKVRMDL-------ER 1050
Cdd:TIGR02168  505 SEGVKALLKNQSGLSGILGVLSELISVDEGyeaAIEAalggrLQAVVVENLNAAKKAIAFLKQNELGRVTFlpldsikGT 584

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1051 AKRKLEGDLKLTQESIMDLENDKQQLDERLKK------------KDFElNALNARIE----------------------- 1095
Cdd:TIGR02168  585 EIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvDDLD-NALELAKKlrpgyrivtldgdlvrpggvitg 663

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1096 -DEQALGSQLQKK--LKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnkkrEAEFQ 1172
Cdd:TIGR02168  664 gSAKTNSSILERRreIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEEL--------------SRQIS 729

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1173 KMRRDLEEATLQHEATAAALRKKHADsVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIiKAKAANLEKMCRT 1252
Cdd:TIGR02168  730 ALRKDLARLEAEVEQLEERIAQLSKE-LTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL-KEELKALREALDE 807

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1253 LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAH 1332
Cdd:TIGR02168  808 LRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEE 887

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1333 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKC 1412
Cdd:TIGR02168  888 ALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDE 967

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1413 SSLEKTKHRLQNEIEDLmvdverSNAAAAALDKkqrnfdkiLAEWKQKYEESQselessqKEARSLSTELFKLKNAYEE- 1491
Cdd:TIGR02168  968 EEARRRLKRLENKIKEL------GPVNLAAIEE--------YEELKERYDFLT-------AQKEDLTEAKETLEEAIEEi 1026

                          730       740
                   ....*....|....*....|....*.
gi 119586555  1492 ----SLEHLETFKRENKNLQEEISDL 1513
Cdd:TIGR02168 1027 dreaRERFKDTFDQVNENFQRVFPKL 1052
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 917-1794 3.09e-20

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 98.60  E-value: 3.09e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   917 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRdIDDLELTLAKVE-----KEKHATENKVKNLTEEMAGLDEIIAK 991
Cdd:TIGR02169  177 EELEEVEENIERLDLIIDEKRQQLERLRREREKAER-YQALLKEKREYEgyellKEKEALERQKEAIERQLASLEEELEK 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   992 LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAK-VKLEQQVDDLEGSLEQekkvrmdlerakrkLEGDLKLTQESIMDLE 1070
Cdd:TIGR02169  256 LTEEISELEKRLEEIEQLLEELNKKIKDLGEEEqLRVKEKIGELEAEIAS--------------LERSIAEKERELEDAE 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1071 NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Cdd:TIGR02169  322 ERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEAtlqhEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFkleldd 1230
Cdd:TIGR02169  402 NELKRELDRLQEELQRLSEELADLNAAIAGI----EAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQEL------ 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1231 vtsnmeqiikakaanlekmcRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEA-------LISQLT 1303
Cdd:TIGR02169  472 --------------------YDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKAsiqgvhgTVAQLG 531

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1304 RGKLTYTQQLEDLKRQ------LEEEVKAKNA--LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1375
Cdd:TIGR02169  532 SVGERYATAIEVAAGNrlnnvvVEDDAVAKEAieLLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPK 611

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1376 YETD---AIQRT---EELEEAKK--------KLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1441
Cdd:TIGR02169  612 YEPAfkyVFGDTlvvEDIEAARRlmgkyrmvTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELS 691

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1442 ALDKKQRNFDKILAEWKQKyeesqselessqkeARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSG 1521
Cdd:TIGR02169  692 SLQSELRRIENRLDELSQE--------------LSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVK 757

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1522 KTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF-NQIKAEIERKLAEKDeemeqAKRNHLRVVDSLQT 1600
Cdd:TIGR02169  758 SELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKlEEEVSRIEARLREIE-----QKLNRLTLEKEYLE 832

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1601 SLDAETRSRNEALRVKKKMEGD-LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDavranddlkeniaiverrn 1679
Cdd:TIGR02169  833 KEIQELQEQRIDLKEQIKSIEKeIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDE------------------- 893

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1680 nlLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM------DADLSQLQTEVEEAVQECRNAE 1753
Cdd:TIGR02169  894 --LEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDeeipeeELSLEDVQAELQRVEEEIRALE 971

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|.
gi 119586555  1754 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1794
Cdd:TIGR02169  972 PVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEY 1012
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1287-1829 4.45e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 97.70  E-value: 4.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1287 ELSRQLDEKEALISQLTRGKLTytQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1366
Cdd:COG1196   217 ELKEELKELEAELLLLKLRELE--AELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1367 SEVAQwrtkyetdAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1446
Cdd:COG1196   295 AELAR--------LEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEA 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1447 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 1526
Cdd:COG1196   367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE 446

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1527 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM---EQAKRNHLR---------- 1593
Cdd:COG1196   447 AAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEgflEGVKAALLLaglrglagav 526

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1594 -VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEI-------QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN 1665
Cdd:COG1196   527 aVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAieylkaaKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVAS 606

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1666 DDLKENIAIVERRNNLLQAELEELRA--------VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQ 1737
Cdd:COG1196   607 DLREADARYYVLGDTLLGRTLVAARLeaalrravTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAE 686

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1738 LQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLE 1817
Cdd:COG1196   687 RLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELE 766

                         570
                  ....*....|....*
gi 119586555 1818 ---ARvreLENELEA 1829
Cdd:COG1196   767 relER---LEREIEA 778
MYSc_Myo33 cd14894
class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 ...
 220-706 1.05e-19

class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276859 [Multi-domain]  Cd Length: 871  Bit Score: 96.35  E-value: 1.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  220 IIQANPALEAFGNAKTVRNDNSSRFGKF--IRIHFGATG---KLASADIETYLLEKSRVIFQL------KAERDYHIFYQ 288
Cdd:cd14894   249 VLDSNIVLEAFGHATTSMNLNSSRFGKMttLQVAFGLHPwefQICGCHISPFLLEKSRVTSERgresgdQNELNFHILYA 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  289 ILSNKKPELLDMLLITNNPYD------YAFISQGETTVASIDDAEELMATD--------NAFDVLGFTSEEKNSMYKLTG 354
Cdd:cd14894   329 MVAGVNAFPFMRLLAKELHLDgidcsaLTYLGRSDHKLAGFVSKEDTWKKDverwqqviDGLDELNVSPDEQKTIFKVLS 408

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  355 AIMHFGNMKFKLKQREEQAEPDGT---EEADKSAYLMGLNSADLLKGLCHPR---VKVGNEYVTKGQNVQQVIYATGALA 428
Cdd:cd14894   409 AVLWLGNIELDYREVSGKLVMSSTgalNAPQKVVELLELGSVEKLERMLMTKsvsLQSTSETFEVTLEKGQVNHVRDTLA 488

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  429 KAVYERMFNWMV------TRINATLETKQPRQY-----------FIGVLDIAGFEIFDFNSFEQLCINFTNEKLqqffnh 491
Cdd:cd14894   489 RLLYQLAFNYVVfvmneaTKMSALSTDGNKHQMdsnasapeavsLLKIVDVFGFEDLTHNSLDQLCINYLSEKL------ 562

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  492 hmFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTF-----KAKLFDNHL--GKSANFQ 564
Cdd:cd14894   563 --YAREEQVIAVAYSSRPHLTARDSEKDVLFIYEHPLGVFASLEELTILHQSENMNAqqeekRNKLFVRNIydRNSSRLP 640

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  565 KPRNIKGKPEAH---------FSLIHYAGIVDYNIIGWLQKNKDPL-NETVVGLYQKSSLKLLSTLFANYAGADAPIEKG 634
Cdd:cd14894   641 EPPRVLSNAKRHtpvllnvlpFVIPHTRGNVIYDANDFVKKNSDFVyANLLVGLKTSNSSHFCRMLNESSQLGWSPNTNR 720

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119586555  635 KGKAKKGSSFQTVSAL---HRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICR 706
Cdd:cd14894   721 SMLGSAESRLSGTKSFvgqFRSHVNVLTSQDDKNMPFYFHCIRPNAKKQPSLVNNDLVEQQCRSQRLIRQMEICR 795
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1128-1908 1.61e-19

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 95.96  E-value: 1.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1128 ARAKVEKLRSDLSRELEEISERLEEAGgatsvqiEMNKKREAEFQK----MRRDLEEATLQHEATAAaLRKKHADSVAEL 1203
Cdd:pfam15921   72 GKEHIERVLEEYSHQVKDLQRRLNESN-------ELHEKQKFYLRQsvidLQTKLQEMQMERDAMAD-IRRRESQSQEDL 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1204 GEQidnLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAAN---LEKMCRTLED-------QMNEHRSKAEETQRSVND 1273
Cdd:pfam15921  144 RNQ---LQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHegvLQEIRSILVDfeeasgkKIYEHDSMSTMHFRSLGS 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1274 LTSQRAK-LQTENGELSRQL----DEKEALISQLTRGKLTYTQQLEDLKRQL--EEEVKAkNALAHALQSARHDCDLLRE 1346
Cdd:pfam15921  221 AISKILReLDTEISYLKGRIfpveDQLEALKSESQNKIELLLQQHQDRIEQLisEHEVEI-TGLTEKASSARSQANSIQS 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1347 QYE----EETEAKAELQRVLSKANSEVAQWRTkyetdaiqrteELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR- 1421
Cdd:pfam15921  300 QLEiiqeQARNQNSMYMRQLSDLESTVSQLRS-----------ELREAKRMYEDKIEELEKQLVLANSELTEARTERDQf 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1422 ------LQNEIEDLMVDV-ERSNAAAAALDKKQRNFDKILAEwKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1494
Cdd:pfam15921  369 sqesgnLDDQLQKLLADLhKREKELSLEKEQNKRLWDRDTGN-SITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQME 447

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1495 -HLETFKRENKNLqEEISDLTEQLGSsgkTIHELEKVRKQLEAEKMELQSA---LEEAEASLEHEEGKILRAQLEFNQIK 1570
Cdd:pfam15921  448 rQMAAIQGKNESL-EKVSSLTAQLES---TKEMLRKVVEELTAKKMTLESSertVSDLTASLQEKERAIEATNAEITKLR 523

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1571 AEIERKLaekdEEMEQAKR--NHLRVVdslQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1648
Cdd:pfam15921  524 SRVDLKL----QELQHLKNegDHLRNV---QTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLE 596

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1649 SLLKDTQIQLDDAVRANDdlKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQElietSERVQLLHSQNTSLiNQK 1728
Cdd:pfam15921  597 KEINDRRLELQEFKILKD--KKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIK----QERDQLLNEVKTSR-NEL 669

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1729 KKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE----LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE-- 1802
Cdd:pfam15921  670 NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQtrntLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQsk 749

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1803 ----QIALKGGKKQLQKLEARVRELENELEA---EQKRNAESVKGMRKSERRIKEltyqteedrkNLLRLQDLVDKLQLK 1875
Cdd:pfam15921  750 iqflEEAMTNANKEKHFLKEEKNKLSQELSTvatEKNKMAGELEVLRSQERRLKE----------KVANMEVALDKASLQ 819

                          810       820       830
                   ....*....|....*....|....*....|...
gi 119586555  1876 VkAYKRQAEEAEEQANTNLskfrKVQHELDEAE 1908
Cdd:pfam15921  820 F-AECQDIIQRQEQESVRL----KLQHTLDVKE 847
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 847-1590 2.18e-19

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 95.52  E-value: 2.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERL 926
Cdd:TIGR02169  294 EKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAEL 373

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   927 EDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAhqqa 1006
Cdd:TIGR02169  374 EEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALE---- 449

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1007 lddLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLK----- 1081
Cdd:TIGR02169  450 ---IKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQgvhgt 526

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1082 -------KKDFEL-------NALNARIEDEQALGSQLQKKLKELQArieeleeeleaERTARAKVEKLRsDLSRELEEIS 1147
Cdd:TIGR02169  527 vaqlgsvGERYATaievaagNRLNNVVVEDDAVAKEAIELLKRRKA-----------GRATFLPLNKMR-DERRDLSILS 594

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1148 ErlEEAGGATSVQIEMNKKREAEFQKMRRD------LEEA----------TLQHE-------ATAAALRKKHADSVA-EL 1203
Cdd:TIGR02169  595 E--DGVIGFAVDLVEFDPKYEPAFKYVFGDtlvvedIEAArrlmgkyrmvTLEGElfeksgaMTGGSRAPRGGILFSrSE 672

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1204 GEQIDNLQRVKQKLEKEKSEFKLELddvtsnmeqiikakaanlekmcRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT 1283
Cdd:TIGR02169  673 PAELQRLRERLEGLKRELSSLQSEL----------------------RRIENRLDELSQELSDASRKIGEIEKEIEQLEQ 730

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1284 ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQsarhdcDLLREQYEEETEakaELQRVLS 1363
Cdd:TIGR02169  731 EEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALN------DLEARLSHSRIP---EIQAELS 801

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1364 KANSEVAQWRtkyetdaiQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAAL 1443
Cdd:TIGR02169  802 KLEEEVSRIE--------ARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEEL 873

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1444 DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKnlqeEISDLTEQLGSSGKT 1523
Cdd:TIGR02169  874 EAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELS----EIEDPKGEDEEIPEE 949

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1524 IHELEKVRKQLEAEKMELQsALEEAE--ASLEHEEGKILRAQLEFNQIKAEIERK-LAEKDEEMEQAKRN 1590
Cdd:TIGR02169  950 ELSLEDVQAELQRVEEEIR-ALEPVNmlAIQEYEEVLKRLDELKEKRAKLEEERKaILERIEEYEKKKRE 1018
PTZ00121 PTZ00121
MAEBL; Provisional
 845-1619 4.48e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 94.82  E-value: 4.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQleaKVKEMNE 924
Cdd:PTZ00121 1158 RKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAE---AVKKAEE 1234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  925 RLEDEEEmnAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNlTEEMAGLDEiiAKLTKEKKALQEAHQ 1004
Cdd:PTZ00121 1235 AKKDAEE--AKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKK-AEEKKKADE--AKKAEEKKKADEAKK 1309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1005 QALDDLQAEEDKVNT------LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDE 1078
Cdd:PTZ00121 1310 KAEEAKKADEAKKKAeeakkkADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEE 1389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1079 RLKKKDFELNALNARIE-DEQALGSQLQKKLKELQARIEELEEELEAERTA----RAKVEKLRSDLSRELEEISERLEEA 1153
Cdd:PTZ00121 1390 KKKADEAKKKAEEDKKKaDELKKAAAAKKKADEAKKKAEEKKKADEAKKKAeeakKADEAKKKAEEAKKAEEAKKKAEEA 1469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1154 GGATSVQIEMNKKREAEfqKMRRDLEEATLQ-HEATAAALRKKHADSV--AELGEQIDNLQRVKQKL---EKEKSEFKLE 1227
Cdd:PTZ00121 1470 KKADEAKKKAEEAKKAD--EAKKKAEEAKKKaDEAKKAAEAKKKADEAkkAEEAKKADEAKKAEEAKkadEAKKAEEKKK 1547

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1228 LDDVtSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ---LDEKEALISQLTR 1304
Cdd:PTZ00121 1548 ADEL-KKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEeakKAEEAKIKAEELK 1626

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1305 GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYETDAIQR 1383
Cdd:PTZ00121 1627 KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEdEKKAAEALKKEAEEAKKAEE 1706

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1384 TEELEEAKKKLAQRLQEAEEAVEavnAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNfdkilAEWKQKYEE 1463
Cdd:PTZ00121 1707 LKKKEAEEKKKAEELKKAEEENK---IKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKK-----AEEIRKEKE 1778

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1464 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE----NKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM 1539
Cdd:PTZ00121 1779 AVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGnlviNDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNN 1858

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1540 EL-QSALEEAEASLEheegKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL-RVVDSLQTSLDAETRSRNEALRVKK 1617
Cdd:PTZ00121 1859 ENgEDGNKEADFNKE----KDLKEDDEEEIEEADEIEKIDKDDIEREIPNNNMAgKNNDIIDDKLDKDEYIKRDAEETRE 1934


                  ..
gi 119586555 1618 KM 1619
Cdd:PTZ00121 1935 EI 1936
PTZ00121 PTZ00121
MAEBL; Provisional
 841-1436 6.23e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 94.44  E-value: 6.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSllQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIqlEAKVK 920
Cdd:PTZ00121 1261 RMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAE--EKKKADEAKKKAEEAKKADEAKKKAEEAKKKA--DAAKK 1336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  921 EMNERLEDEEEMNAELTAKKRKLEDecSELKRDIDDLEltlaKVEKEKHATENKVKnlTEEMAGLDEIIAKLTKEKKALQ 1000
Cdd:PTZ00121 1337 KAEEAKKAAEAAKAEAEAAADEAEA--AEEKAEAAEKK----KEEAKKKADAAKKK--AEEKKKADEAKKKAEEDKKKAD 1408

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1001 EAHQQALDDLQAEEdkvntlTKAKVKLEQQVDDLEGSLEQEKKVrmdlERAKRKLEGDLKltqesimdLENDKQQLDERL 1080
Cdd:PTZ00121 1409 ELKKAAAAKKKADE------AKKKAEEKKKADEAKKKAEEAKKA----DEAKKKAEEAKK--------AEEAKKKAEEAK 1470

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1081 KKKDFELNALNARIEDEqalgsqLQKKLKELQARIEELEEELEAERTA---RAKVEKLRSDLSRELEEiSERLEEAGGAT 1157
Cdd:PTZ00121 1471 KADEAKKKAEEAKKADE------AKKKAEEAKKKADEAKKAAEAKKKAdeaKKAEEAKKADEAKKAEE-AKKADEAKKAE 1543

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1158 SVQI--EMNKKREAEFQKMRRDLEEATLQHEATAAALRKkhadsvAELGEQIDNlQRVKQKLEKEKSEFKLELDDVTSNM 1235
Cdd:PTZ00121 1544 EKKKadELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK------AEEAKKAEE-ARIEEVMKLYEEEKKMKAEEAKKAE 1616

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1236 EQIIKAkaanlekmcrtledqmnEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1315
Cdd:PTZ00121 1617 EAKIKA-----------------EELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEE 1679

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1316 LKRQLEEEVKAKNALAHALQSARhDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEEL---EEAKK 1392
Cdd:PTZ00121 1680 AKKAEEDEKKAAEALKKEAEEAK-KAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK-KKAEEAkkdEEEKK 1757

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 119586555 1393 KLAQRLQEAEEAVEAVNAKCSSLekTKHRLQNEIEDLMVDVERS 1436
Cdd:PTZ00121 1758 KIAHLKKEEEKKAEEIRKEKEAV--IEEELDEEDEKRRMEVDKK 1799
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 987-1802 1.04e-18

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 93.26  E-value: 1.04e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   987 EIIAKLTKE--KKALQEAHQQaLDDLQAEEDKVNTL-TKAKVKLEQQVDDLEGSLEQ---EKKVRMDLERAKRKLEGDLK 1060
Cdd:pfam15921   66 KIIAYPGKEhiERVLEEYSHQ-VKDLQRRLNESNELhEKQKFYLRQSVIDLQTKLQEmqmERDAMADIRRRESQSQEDLR 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1061 -LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQAR-----IEELEEELEAERTARAKVEK 1134
Cdd:pfam15921  145 nQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEAsgkkiYEHDSMSTMHFRSLGSAISK 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1135 LRSDLSRELEEISERLEEAGGA-TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV 1213
Cdd:pfam15921  225 ILRELDTEISYLKGRIFPVEDQlEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEII 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1214 KQKLEKEKSEFKLELDDVTSNMEQIikakAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLd 1293
Cdd:pfam15921  305 QEQARNQNSMYMRQLSDLESTVSQL----RSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQL- 379

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1294 ekEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHalqsarhdcdlLREQYEEETEAKAELQRVLSKANSEvAQWR 1373
Cdd:pfam15921  380 --QKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH-----------LRRELDDRNMEVQRLEALLKAMKSE-CQGQ 445

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1374 TKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLmvdversnaaAAALDKKQRNFDKI 1453
Cdd:pfam15921  446 MERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDL----------TASLQEKERAIEAT 515

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1454 LAEwkqkYEESQSELESSQKEARSLSTELFKLKNAYEESlEHLETFKRENKN----LQEEISDLTEQLGSSGKTIHELEK 1529
Cdd:pfam15921  516 NAE----ITKLRSRVDLKLQELQHLKNEGDHLRNVQTEC-EALKLQMAEKDKvieiLRQQIENMTQLVGQHGRTAGAMQV 590

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1530 VRKQLEAE----KMELQS---ALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK-RNHLRVVDSLQT 1600
Cdd:pfam15921  591 EKAQLEKEindrRLELQEfkiLKDKKDAKIRELEARVSDLELEkVKLVNAGSERLRAVKDIKQERDQlLNEVKTSRNELN 670

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1601 SLDAETRSRNEALRVK-KKMEGDLNEMEIQLShanrmaaEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN 1679
Cdd:pfam15921  671 SLSEDYEVLKRNFRNKsEEMETTTNKLKMQLK-------SAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQI 743

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1680 NLLQAELEELRAVVEQTERSRKLAEQELIETSERVqllhsqnTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKA 1759
Cdd:pfam15921  744 DALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQEL-------STVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKA 816

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|...
gi 119586555  1760 ITDAAMMAEELKKEQDTSAHLErmkknmeqtikdLQHRLDEAE 1802
Cdd:pfam15921  817 SLQFAECQDIIQRQEQESVRLK------------LQHTLDVKE 847
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
870-1429 1.85e-18

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 92.41  E-value: 1.85e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  870 RKELEEKmvsllqEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTakkrkledecsE 949
Cdd:PRK02224  193 KAQIEEK------EEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELE-----------T 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  950 LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEkKALQEAHQQALDDLQAEedkvntltkakvkLEQ 1029
Cdd:PRK02224  256 LEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAE-AGLDDADAEAVEARREE-------------LED 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1030 QVDDLEGSLEQekkVRMDLERAKRKLEGdlklTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLK 1109
Cdd:PRK02224  322 RDEELRDRLEE---CRVAAQAHNEEAES----LREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIE 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1110 ELQARIEELEeeleaerTARAKVEKLRSDLSRELEEISERLEEAggATSVQIEMNKKREAEfqkmrrDLEEATLQHEATA 1189
Cdd:PRK02224  395 ELRERFGDAP-------VDLGNAEDFLEELREERDELREREAEL--EATLRTARERVEEAE------ALLEAGKCPECGQ 459

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1190 AALRKKHADSVAELGEQIDnlqrvkqKLEKEKSEFKLELDDVTSNMEQIIKAKAA-----NLEKMCRTLEDQMNEHRSKA 1264
Cdd:PRK02224  460 PVEGSPHVETIEEDRERVE-------ELEAELEDLEEEVEEVEERLERAEDLVEAedrieRLEERREDLEELIAERRETI 532

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1265 EETQRSVNDLTSQRAKLQTEnGELSRQLDEKEALISQLTRGKL-TYTQQLEDLKRQLEEEVKAKNALAhALQSARHDCDL 1343
Cdd:PRK02224  533 EEKRERAEELRERAAELEAE-AEEKREAAAEAEEEAEEAREEVaELNSKLAELKERIESLERIRTLLA-AIADAEDEIER 610

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1344 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIqrtEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQ 1423
Cdd:PRK02224  611 LREKREALAELNDERRERLAEKRERKRELEAEFDEARI---EEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVE 687


                  ....*.
gi 119586555 1424 NEIEDL 1429
Cdd:PRK02224  688 NELEEL 693
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1254-1928 2.70e-18

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 92.16  E-value: 2.70e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1254 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLD-------EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKA 1326
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQaetelcaEAEEMRARLAARKQELEEILHELESRLEEEEER 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1327 KNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEeLEEAKKKLAQRLQEAEEAVE 1406
Cdd:pfam01576   91 SQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSK-LSKERKLLEERISEFTSNLA 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1407 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1486
Cdd:pfam01576  170 EEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAAL 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1487 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF 1566
Cdd:pfam01576  250 ARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRSKREQEV 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1567 NQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 1646
Cdd:pfam01576  330 TELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKK 409

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1647 LQSLLKDTQIQLDDAVRANDDLKEniaiverRNNLLQAELEELRAVVEQTE-RSRKLA------EQELIETSERVQLLHS 1719
Cdd:pfam01576  410 LEGQLQELQARLSESERQRAELAE-------KLSKLQSELESVSSLLNEAEgKNIKLSkdvsslESQLQDTQELLQEETR 482

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1720 QNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD 1799
Cdd:pfam01576  483 QKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLE 562

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1800 EAEQIALKggkkqLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTyqtEEDRKNLLRLQDLVDKlqlkvkay 1879
Cdd:pfam01576  563 EKAAAYDK-----LEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQML---AEEKAISARYAEERDR-------- 626

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*....
gi 119586555  1880 krqaeeAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1928
Cdd:pfam01576  627 ------AEAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDL 669
PTZ00121 PTZ00121
MAEBL; Provisional
 1156-1912 5.89e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.36  E-value: 5.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1156 ATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAElGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM 1235
Cdd:PTZ00121 1089 ADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARK-AEDARKAEEARKAEDAKRVEIARKAEDARKAE 1167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1236 EQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVndlTSQRAKLQTENGELSRQLDEKealisqltrgKLTYTQQLED 1315
Cdd:PTZ00121 1168 EARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAE---AARKAEEERKAEEARKAEDAK----------KAEAVKKAEE 1234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1316 LKRQlEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRvlsKANsEVAQWRTKYETDAIQRTEE---LEEAKK 1392
Cdd:PTZ00121 1235 AKKD-AEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEAR---KAD-ELKKAEEKKKADEAKKAEEkkkADEAKK 1309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1393 KlaqrlqeAEEAVEAVNAKCSSLEKTKhrlqnEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1472
Cdd:PTZ00121 1310 K-------AEEAKKADEAKKKAEEAKK-----KADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAK 1377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1473 KEARSLSTELFKLKNAyeeslEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKmELQSALEEAEASL 1552
Cdd:PTZ00121 1378 KKADAAKKKAEEKKKA-----DEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKK-KAEEAKKADEAKK 1451

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1553 EHEEGKilraqlefnqiKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAEtRSRNEALRVKKKMEGDLNEMEIQLSH 1632
Cdd:PTZ00121 1452 KAEEAK-----------KAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAE-EAKKKADEAKKAAEAKKKADEAKKAE 1519

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1633 ANRMAAEAQK--QVKSLQSLLKDTQIQLDDAVRANDDLKEniaiVERRNNLLQAELEELRavveqteRSRKLAEQELIET 1710
Cdd:PTZ00121 1520 EAKKADEAKKaeEAKKADEAKKAEEKKKADELKKAEELKK----AEEKKKAEEAKKAEED-------KNMALRKAEEAKK 1588

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1711 SERVQLlhSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1790
Cdd:PTZ00121 1589 AEEARI--EEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEE 1666

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1791 IKDLQHRLDEAEQiALKGGKKQLQKLEARVREleneleAEQKRNAESVKGMRKSERRIKELTYQTEEDRKnllrlqdlvd 1870
Cdd:PTZ00121 1667 AKKAEEDKKKAEE-AKKAEEDEKKAAEALKKE------AEEAKKAEELKKKEAEEKKKAEELKKAEEENK---------- 1729

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*
gi 119586555 1871 klqLKVKAYKRQAEEAE---EQANTNLSKFRKVQHELDEAEERAD 1912
Cdd:PTZ00121 1730 ---IKAEEAKKEAEEDKkkaEEAKKDEEEKKKIAHLKKEEEKKAE 1771
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 931-1786 1.37e-17

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 89.65  E-value: 1.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   931 EMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL 1010
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQEL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1011 QAEEDKVNTLTKAKVKLEQQvddlegSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Cdd:pfam02463  246 LRDEQEEIESSKQEIEKEEE------KLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKES 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1091 NARIEdeqalgsQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Cdd:pfam02463  320 EKEKK-------KAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKL 392

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1171 FQKMRRDLEEatlqhEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAANLEKMC 1250
Cdd:pfam02463  393 KEEELELKSE-----EEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELEL 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1251 RTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNAL 1330
Cdd:pfam02463  468 KKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAIST 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1331 AHALQSAR--HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1408
Cdd:pfam02463  548 AVIVEVSAtaDEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEG 627

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1409 NAKCSSL--EKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1486
Cdd:pfam02463  628 ILKDTELtkLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQR 707

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1487 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF 1566
Cdd:pfam02463  708 EKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLK 787

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1567 NQIKAEIERKLAEKDEEMEQAKRNH----LRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQlsHANRMAAEAQK 1642
Cdd:pfam02463  788 VEEEKEEKLKAQEEELRALEEELKEeaelLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEE--ELERLEEEITK 865

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1643 QVKSLQSLLKDTQIQLDDAVRanddlkENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNT 1722
Cdd:pfam02463  866 EELLQELLLKEEELEEQKLKD------ELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEE 939

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119586555  1723 SLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1786
Cdd:pfam02463  940 LLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEE 1003
PTZ00121 PTZ00121
MAEBL; Provisional
 1077-1884 1.66e-17

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 89.82  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1077 DERLK--KKDFELNALNARIEDEQAlgSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1154
Cdd:PTZ00121 1069 DEGLKpsYKDFDFDAKEDNRADEAT--EEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEAR 1146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1155 GATSVQIEMNKKREAEFQKMR--RDLEEATLQHEA-------TAAALRKKHADSVAELGEQIDNLQR---VKQKLEKEKS 1222
Cdd:PTZ00121 1147 KAEDAKRVEIARKAEDARKAEeaRKAEDAKKAEAArkaeevrKAEELRKAEDARKAEAARKAEEERKaeeARKAEDAKKA 1226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1223 EFKLELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSvndlTSQRAKLQTENGELSRQLDEKEalisql 1302
Cdd:PTZ00121 1227 EAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKA----EEARKADELKKAEEKKKADEAK------ 1296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1303 trgKLTYTQQLEDLKRQLEEEVKAKNALAHAlQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ 1382
Cdd:PTZ00121 1297 ---KAEEKKKADEAKKKAEEAKKADEAKKKA-EEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKK 1372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1383 RteelEEAKKKLAQRLQEAEEAVEAVNAKCSSLEktkhrlqneiedlmvdversnaaaaalDKKQRNFDKILAEWKQKyE 1462
Cdd:PTZ00121 1373 K----EEAKKKADAAKKKAEEKKKADEAKKKAEE---------------------------DKKKADELKKAAAAKKK-A 1420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1463 ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ 1542
Cdd:PTZ00121 1421 DEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKAD 1500

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1543 SALEEAEASLEHEEGKilRAQlefNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 1622
Cdd:PTZ00121 1501 EAKKAAEAKKKADEAK--KAE---EAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEED 1575

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1623 LNEmeiqlshANRMAAEAQKQVKSlqsllkdtqiQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL 1702
Cdd:PTZ00121 1576 KNM-------ALRKAEEAKKAEEA----------RIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQL 1638

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1703 AEQELIETSERVQLLHSQNTSLINQkkkmdADLSQLQTEVEEAVQECRNAEEKAKKAitdaammAEELKKEQDTSAHLER 1782
Cdd:PTZ00121 1639 KKKEAEEKKKAEELKKAEEENKIKA-----AEEAKKAEEDKKKAEEAKKAEEDEKKA-------AEALKKEAEEAKKAEE 1706

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1783 MKKNMEQTIKdlqhrldEAEQIalkggKKQLQKLEARVRELENELEaEQKRNAESVKGMRKSERRIKELTYQTEEDRKNL 1862
Cdd:PTZ00121 1707 LKKKEAEEKK-------KAEEL-----KKAEEENKIKAEEAKKEAE-EDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEI 1773

                         810       820
                  ....*....|....*....|..
gi 119586555 1863 LRLQDLVDKLQLKVKAYKRQAE 1884
Cdd:PTZ00121 1774 RKEKEAVIEEELDEEDEKRRME 1795
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 858-1574 2.79e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 88.15  E-value: 2.79e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   858 RLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLiKNKIQ-LEAKVKEMNERLEDEEEMNAEL 936
Cdd:TIGR04523   23 GYKNIANKQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNS-NNKIKiLEQQIKDLNDKLKKNKDKINKL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   937 TAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE-------NKVKNLTEEMAGLDEIIAKLTKEKKALqeahqqaldd 1009
Cdd:TIGR04523  102 NSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKknidkflTEIKKKEKELEKLNNKYNDLKKQKEEL---------- 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1010 lqaeEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLErakrKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089
Cdd:TIGR04523  172 ----ENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLK----KKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINE 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1090 LNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEaggatsvqiEMNKKREA 1169
Cdd:TIGR04523  244 KTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQ---------DWNKELKS 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1170 EFQKMRRDLEEATLQheataaalRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAANLEKM 1249
Cdd:TIGR04523  315 ELKNQEKKLEEIQNQ--------ISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEI 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1250 cRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLtrgkltyTQQLEDLKRQLEEEVKAKNA 1329
Cdd:TIGR04523  387 -KNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKN-------NSEIKDLTNQDSVKELIIKN 458

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1330 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVaqwrtkyetdaiqrtEELEEAKKKLAQRLQEAEEAVEAVN 1409
Cdd:TIGR04523  459 LDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKEL---------------KKLNEEKKELEEKVKDLTKKISSLK 523

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1410 AKCSSLEKTKHRLQNEIEDLMVDVER--SNAAAAALDKKQRNFDKILAEWKQKYEesqselessqkearslstelfKLKN 1487
Cdd:TIGR04523  524 EKIEKLESEKKEKESKISDLEDELNKddFELKKENLEKEIDEKNKEIEELKQTQK---------------------SLKK 582

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1488 AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1567
Cdd:TIGR04523  583 KQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWP 662


                   ....*..
gi 119586555  1568 QIKAEIE 1574
Cdd:TIGR04523  663 EIIKKIK 669
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 854-1730 3.80e-17

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 88.49  E-value: 3.80e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   854 EEFTRLKEALEKsearRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERcdQLIKNKIQLEAKVKEMNERLEDEEEMN 933
Cdd:pfam02463  166 RLKRKKKEALKK----LIEETENLAELIIDLEELKLQELKLKEQAKKALEY--YQLKEKLELEEEYLLYLDYLKLNEERI 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   934 AELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 1013
Cdd:pfam02463  240 DLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKES 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1014 EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEgdlkltqesiMDLENDKQQLDERLKKKDFELNALNAR 1093
Cdd:pfam02463  320 EKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELE----------KLQEKLEQLEEELLAKKKLESERLSSA 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1094 IEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1173
Cdd:pfam02463  390 AKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKK 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1174 MRRDLEEATLQHEATAAALRkkhadsvaelgEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAANLEKMCRTL 1253
Cdd:pfam02463  470 SEDLLKETQLVKLQEQLELL-----------LSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAV 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1254 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1333
Cdd:pfam02463  539 ENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADED 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1334 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDaiQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1413
Cdd:pfam02463  619 DKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEV--KASLSELTKELLEIQELQEKAESELAKEEILR 696

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1414 SLEKTKHRLQNEIEDL-MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNaYEES 1492
Cdd:pfam02463  697 RQLEIKKKEQREKEELkKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSL-KEKE 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1493 LEHLETFKRENKNLQEEISDLTEQLGSsgktihELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE 1572
Cdd:pfam02463  776 LAEEREKTEKLKVEEEKEEKLKAQEEE------LRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLE 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1573 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLShanRMAAEAQKQVKSLQSLLK 1652
Cdd:pfam02463  850 KLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQK---LNLLEEKENEIEERIKEE 926

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1653 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ--ELIETSERVQLLHSQNTSLINQKKK 1730
Cdd:pfam02463  927 AEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAieEFEEKEERYNKDELEKERLEEEKKK 1006
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 939-1588 3.10e-16

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 85.07  E-value: 3.10e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   939 KKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD----EIIAKLTKEKKALQEAHQqaldDLQAEE 1014
Cdd:TIGR04523   34 EEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEqqikDLNDKLKKNKDKINKLNS----DLSKIN 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1015 DKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI 1094
Cdd:TIGR04523  110 SEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNI 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1095 EDEQALGSQLQKKLKELQARIEeleeeleaertaraKVEKLRSDLSrELEEISERLEEAggATSVQIEMNKKrEAEFQKM 1174
Cdd:TIGR04523  190 DKIKNKLLKLELLLSNLKKKIQ--------------KNKSLESQIS-ELKKQNNQLKDN--IEKKQQEINEK-TTEISNT 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1175 RRDLEEATLQHEATAAALRKKHADsVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMeqiIKAKAANLEKMCRTLE 1254
Cdd:TIGR04523  252 QTQLNQLKDEQNKIKKQLSEKQKE-LEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKE---LKSELKNQEKKLEEIQ 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1255 DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ---LEEEVKAKNALA 1331
Cdd:TIGR04523  328 NQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQindLESKIQNQEKLN 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1332 HALQSARHDCDLLREQYEEETEakaELQRVLSKANSEVaqwrtkyeTDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAK 1411
Cdd:TIGR04523  408 QQKDEQIKKLQQEKELLEKEIE---RLKETIIKNNSEI--------KDLTNQDSVKELIIKNLDNTRESLETQLKVLSRS 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1412 CSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKnaYEE 1491
Cdd:TIGR04523  477 INKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDD--FEL 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1492 SLEHLETFKRENknlQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1571
Cdd:TIGR04523  555 KKENLEKEIDEK---NKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSS 631

                          650
                   ....*....|....*..
gi 119586555  1572 EIERKLAEKDEEMEQAK 1588
Cdd:TIGR04523  632 IIKNIKSKKNKLKQEVK 648
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 845-1581 3.31e-16

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 85.48  E-value: 3.31e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLadaeeRCDQLIKNKIQLEAKVKEMNE 924
Cdd:TIGR00606  310 HQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHI-----RARDSLIQSLATRLELDGFER 384

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   925 RLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Cdd:TIGR00606  385 GPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQ 464

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1005 QALDDLQAEEDKVNTLTKAKVKLEQ-----QVDDLEGSLEQEKKVRMDLERAKRKLEGDL------KLTQESIMDLENDK 1073
Cdd:TIGR00606  465 QLEGSSDRILELDQELRKAERELSKaeknsLTETLKKEVKSLQNEKADLDRKLRKLDQEMeqlnhhTTTRTQMEMLTKDK 544

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1074 QQLDERLKKKDF----ELNALNARIEDEQALGSQLQKKLKE---LQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1146
Cdd:TIGR00606  545 MDKDEQIRKIKSrhsdELTSLLGYFPNKKQLEDWLHSKSKEinqTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSY 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1147 SERLEEAGGATSVQIEMNKKREaEFQKMRRDLE-------------EATLQHEATAAALRKKHADSVAELGEQIDNLQRV 1213
Cdd:TIGR00606  625 EDKLFDVCGSQDEESDLERLKE-EIEKSSKQRAmlagatavysqfiTQLTDENQSCCPVCQRVFQTEAELQEFISDLQSK 703

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1214 KQKLEKEKSEFKLELDDVTSNMEQII---KAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR 1290
Cdd:TIGR00606  704 LRLAPDKLKSTESELKKKEKRRDEMLglaPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEES 783

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1291 QLDEK------EALISQLTRGKLTYTQQLE-----DLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1359
Cdd:TIGR00606  784 AKVCLtdvtimERFQMELKDVERKIAQQAAklqgsDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLK 863

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1360 RVLSKANSEVAQWRTkyetdAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1439
Cdd:TIGR00606  864 SKTNELKSEKLQIGT-----NLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKK 938

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1440 AA-ALDKKQRNFDKILAEWK--QKYEESQSELESSQKEarslsTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1516
Cdd:TIGR00606  939 AQdKVNDIKEKVKNIHGYMKdiENKIQDGKDDYLKQKE-----TELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQ 1013

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1517 ---------LGSSGKTIHELEKVRKQLEAEKMELQ--------SALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAE 1579
Cdd:TIGR00606 1014 erwlqdnltLRKRENELKEVEEELKQHLKEMGQMQvlqmkqehQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELRE 1093


                   ..
gi 119586555  1580 KD 1581
Cdd:TIGR00606 1094 PQ 1095
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1271-1932 6.51e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 84.35  E-value: 6.51e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1271 VNDLTSQRAKLQTENGELSRQLDEKEALISQLTrgkltytQQLEDLKRQLEEEVKAKN-----------ALAHALQSARH 1339
Cdd:TIGR02169  165 VAEFDRKKEKALEELEEVEENIERLDLIIDEKR-------QQLERLRREREKAERYQAllkekreyegyELLKEKEALER 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1340 DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTK 1419
Cdd:TIGR02169  238 QKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKEREL 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1420 HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF 1499
Cdd:TIGR02169  318 EDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1500 KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAE 1579
Cdd:TIGR02169  398 KREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEE 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1580 KD---EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG------DLNEME------IQLSHANRM-------- 1636
Cdd:TIGR02169  478 YDrveKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGvhgtvaQLGSVGeryataIEVAAGNRLnnvvvedd 557

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1637 --AAEAQKQVKS-------------LQSLLKDTQIQLDDAVRAN-------DDLKENIAIVERRNNLLQAELEELRAVVE 1694
Cdd:TIGR02169  558 avAKEAIELLKRrkagratflplnkMRDERRDLSILSEDGVIGFavdlvefDPKYEPAFKYVFGDTLVVEDIEAARRLMG 637

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1695 Q----------------------TERSRKL----AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1748
Cdd:TIGR02169  638 KyrmvtlegelfeksgamtggsrAPRGGILfsrsEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRK 717

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1749 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEAR-----VREL 1823
Cdd:TIGR02169  718 IGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEE-DLHKLEEALNDLEARlshsrIPEI 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1824 ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHE 1903
Cdd:TIGR02169  797 QAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAA 876

                          730       740
                   ....*....|....*....|....*....
gi 119586555  1904 LDEAEERADIAESQVNKLRAKSRDIGTKR 1932
Cdd:TIGR02169  877 LRDLESRLGDLKKERDELEAQLRELERKI 905
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1259-1841 8.57e-16

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 83.55  E-value: 8.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1259 EHRSKAEETQRSVNDLTSQRaklQTENGELSRQLDEKEA--LISQLTRgkltytqqLEDLKRQLEEEVKAKNALAHALQS 1336
Cdd:PRK02224  166 EYRERASDARLGVERVLSDQ---RGSLDQLKAQIEEKEEkdLHERLNG--------LESELAELDEEIERYEEQREQARE 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1337 ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET------DAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1410
Cdd:PRK02224  235 TRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREREElaeevrDLRERLEELEEERDDLLAEAGLDDADAEAVEA 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1411 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQkyeesqselessqkEARSLSTELfklknayE 1490
Cdd:PRK02224  315 RREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELRE--------------EAAELESEL-------E 373

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1491 ESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIK 1570
Cdd:PRK02224  374 EAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGK 453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1571 -----------------AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA-ETRSRNEALRVKKKMEGDL-NEMEIQLS 1631
Cdd:PRK02224  454 cpecgqpvegsphvetiEEDRERVEELEAELEDLEEEVEEVEERLERAEDLvEAEDRIERLEERREDLEELiAERRETIE 533

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1632 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERsRKLAEQELIETS 1711
Cdd:PRK02224  534 EKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLAA-IADAEDEIERLR 612

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1712 ERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEA-VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1790
Cdd:PRK02224  613 EKREALAELNDERRERLAEKRERKRELEAEFDEArIEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEE 692

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 119586555 1791 IKDLQHRLDeaeqiALKGGKKQLQKLEARVRELEN---ELEAE-QKRNAESVKGM 1841
Cdd:PRK02224  693 LEELRERRE-----ALENRVEALEALYDEAEELESmygDLRAElRQRNVETLERM 742
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1485-1927 1.46e-15

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 83.24  E-value: 1.46e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1485 LKNAYEESLEHLETfkreNKNLQEEIsdlteqLGSSGKTIHELEKVRKQLEAEKMELQSAL---EEAEASLEHEEGKIlr 1561
Cdd:pfam15921  143 LRNQLQNTVHELEA----AKCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILvdfEEASGKKIYEHDSM-- 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1562 AQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTsLDAETRSRNEAL--RVKKKMEGDLNEMEIQLSHANRMAAE 1639
Cdd:pfam15921  211 STMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEA-LKSESQNKIELLlqQHQDRIEQLISEHEVEITGLTEKASS 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1640 AQKQVKSLQSLLKDTQIQlddavranddlkeniaiVERRNNLLQAELEELRAVVEQTE---RSRKLAEQELIETSERVQL 1716
Cdd:pfam15921  290 ARSQANSIQSQLEIIQEQ-----------------ARNQNSMYMRQLSDLESTVSQLRselREAKRMYEDKIEELEKQLV 352

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1717 LhsqntslinqkkkMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH 1796
Cdd:pfam15921  353 L-------------ANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRR 419

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1797 RLDEAEQialkggkkQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV 1876
Cdd:pfam15921  420 ELDDRNM--------EVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTL 491

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1877 KAYKR----------QAEEAEEQANTNLSKFR--------KVQHELDEAEERADI-AESQVNKLRAKSRD 1927
Cdd:pfam15921  492 ESSERtvsdltaslqEKERAIEATNAEITKLRsrvdlklqELQHLKNEGDHLRNVqTECEALKLQMAEKD 561
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 840-1402 1.46e-15

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 83.24  E-value: 1.46e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNladAEERCDQLIKNKIQLEAKV 919
Cdd:pfam15921  250 LKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQ---ARNQNSMYMRQLSDLESTV 326

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   920 kemnerledeEEMNAELTAKKRKLEDECSELKRD--IDDLELTLAKVEKEKHATENkvKNLTEEmagLDEIIAKLTKEKK 997
Cdd:pfam15921  327 ----------SQLRSELREAKRMYEDKIEELEKQlvLANSELTEARTERDQFSQES--GNLDDQ---LQKLLADLHKREK 391

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   998 ALQEAHQQ--------------------ALDDLQAEEDKVNTLTKA-----KVKLEQQVDDLEG---SLEQEKKVRMDLE 1049
Cdd:pfam15921  392 ELSLEKEQnkrlwdrdtgnsitidhlrrELDDRNMEVQRLEALLKAmksecQGQMERQMAAIQGkneSLEKVSSLTAQLE 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1050 RAKRKLEGDLKLTQESIMDLENDKQ---QLDERLKKKDFELNALNARIedeQALGSQLQKKLKELQ------ARIEELEE 1120
Cdd:pfam15921  472 STKEMLRKVVEELTAKKMTLESSERtvsDLTASLQEKERAIEATNAEI---TKLRSRVDLKLQELQhlknegDHLRNVQT 548

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1121 ELEAERTARAKVEKLRSDLSRELEEISERLEEAG-GATSVQIEmNKKREAEFQKMRRDLEEATLqheataaaLRKKHADS 1199
Cdd:pfam15921  549 ECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGrTAGAMQVE-KAQLEKEINDRRLELQEFKI--------LKDKKDAK 619

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1200 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI---IKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTS 1276
Cdd:pfam15921  620 IRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLlneVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKM 699

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1277 QRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ----------LEEEVKAKNALAHALQSARH------- 1339
Cdd:pfam15921  700 QLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQidalqskiqfLEEAMTNANKEKHFLKEEKNklsqels 779

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119586555  1340 -----------DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRtkyetDAIQRTEElEEAKKKLAQRLQEAE 1402
Cdd:pfam15921  780 tvateknkmagELEVLRSQERRLKEKVANMEVALDKASLQFAECQ-----DIIQRQEQ-ESVRLKLQHTLDVKE 847
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
901-1453 1.47e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 79.72  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  901 AEERCDQLIKNKIQ-LEAKVKEMNERLEDEEEMNAELtAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLT 979
Cdd:PRK03918  187 RTENIEELIKEKEKeLEEVLREINEISSELPELREEL-EKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELE 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  980 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLtKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE--- 1056
Cdd:PRK03918  266 ERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYL-DELREIEKRLSRLEEEINGIEERIKELEEKEERLEelk 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1057 GDLKLTQESIMDLENDKQQLDERLKKKDfELNALNARIEDEQAlgSQLQKKLKELQARIEELEEELEAERTARAKVEKLR 1136
Cdd:PRK03918  345 KKLKELEKRLEELEERHELYEEAKAKKE-ELERLKKRLTGLTP--EKLEKELEELEKAKEEIEEEISKITARIGELKKEI 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1137 SDLSRELEEiserLEEAGGATSVQiemnkKREAEFQKMRRDLEEATLQheataaalRKKHADSVAELGEQIDNLQRVKQK 1216
Cdd:PRK03918  422 KELKKAIEE----LKKAKGKCPVC-----GRELTEEHRKELLEEYTAE--------LKRIEKELKEIEEKERKLRKELRE 484

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1217 LEKEKSEFKlELDDVTSNMEQII----KAKAANLEKMCRTLED--QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR 1290
Cdd:PRK03918  485 LEKVLKKES-ELIKLKELAEQLKeleeKLKKYNLEELEKKAEEyeKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEK 563

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1291 QLDEKEA----LISQLTRGKLTYTQQLEDLKRQLE----EEVKAKNAlAHALQSARHDCDLLREQYEEETEAKAELQRVL 1362
Cdd:PRK03918  564 KLDELEEelaeLLKELEELGFESVEELEERLKELEpfynEYLELKDA-EKELEREEKELKKLEEELDKAFEELAETEKRL 642

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1363 SKANSEVAQWRTKYETDaiqRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1442
Cdd:PRK03918  643 EELRKELEELEKKYSEE---EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKA 719

                         570
                  ....*....|.
gi 119586555 1443 LDKKQRNFDKI 1453
Cdd:PRK03918  720 LERVEELREKV 730
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
 32-76 3.27e-14

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


Pssm-ID: 460670  Cd Length: 45  Bit Score: 68.23  E-value: 3.27e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 119586555    32 DLKKDVFVPDDKQEFVKAKIVSREGGKVTAETEYGKTVTVKEDQV 76
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIKEEEGDKVTVETEDGKTVTVKKDDV 45
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1053-1801 4.67e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 77.75  E-value: 4.67e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1053 RKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKelqarieeleeeleaerTARAKV 1132
Cdd:TIGR04523   36 KQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLK-----------------KNKDKI 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1133 EKLRSDLSRELEEISERLEEaggatsvqieMNKKrEAEFQKMRRDLEEATLQHEATAAALRKKHADsVAELGEQIDNLQR 1212
Cdd:TIGR04523   99 NKLNSDLSKINSEIKNDKEQ----------KNKL-EVELNKLEKQKKENKKNIDKFLTEIKKKEKE-LEKLNNKYNDLKK 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1213 VKQKLEKEKSEFKLELDDVTSNMEQIiKAKAANLEKMCRTLEDQMNEHRSkaeetqrsvndLTSQRAKLQTENGELSRQL 1292
Cdd:TIGR04523  167 QKEELENELNLLEKEKLNIQKNIDKI-KNKLLKLELLLSNLKKKIQKNKS-----------LESQISELKKQNNQLKDNI 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1293 DEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAknalahaLQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ- 1371
Cdd:TIGR04523  235 EKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQ-------LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQd 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1372 WRTKYETDAIQRTEELEEAKKKLAQrlqeAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1451
Cdd:TIGR04523  308 WNKELKSELKNQEKKLEEIQNQISQ----NNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYK 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1452 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVR 1531
Cdd:TIGR04523  384 QEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTR 463

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1532 KQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE---IERKLAEKDEEMEQAKRNhLRVVDSLQTSLDAETRS 1608
Cdd:TIGR04523  464 ESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEkkeLEEKVKDLTKKISSLKEK-IEKLESEKKEKESKISD 542

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1609 RNEALrVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEE 1688
Cdd:TIGR04523  543 LEDEL-NKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEK 621

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1689 LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKA----KKAIT--- 1761
Cdd:TIGR04523  622 AKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKELslhyKKYITrmi 701

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|...
gi 119586555  1762 ---DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA 1801
Cdd:TIGR04523  702 rikDLPKLEEKYKEIEKELKKLDEFSKELENIIKNFNKKFDDA 744
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1037-1927 5.16e-14

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 78.16  E-value: 5.16e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1037 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFElNALNARIEDEQALGSQLQKKLKELQARIE 1116
Cdd:TIGR00606  187 ALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESS-REIVKSYENELDPLKNRLKEIEHNLSKIM 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1117 ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGatsvQIEMNKKREA-EFQKMRRDLEEATLQHEATAAALRKK 1195
Cdd:TIGR00606  266 KLDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLN----DLYHNHQRTVrEKERELVDCQRELEKLNKERRLLNQE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1196 HADSVAELGE-----QIDNLQRVKQKLEKEKSEFKLELD------DVTSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKA 1264
Cdd:TIGR00606  342 KTELLVEQGRlqlqaDRHQEHIRARDSLIQSLATRLELDgfergpFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKE 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1265 EETQRSVNDLTSQRAKL----QTENGELSRQLDEKEALISQLTRGkltyTQQLEDLKRQLEEEVKAKNALAHALQSARHD 1340
Cdd:TIGR00606  422 RLKQEQADEIRDEKKGLgrtiELKKEILEKKQEELKFVIKELQQL----EGSSDRILELDQELRKAERELSKAEKNSLTE 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1341 CDLLREQYEEETeaKAELQRVLSKANSEVAQwrTKYETDAIQRTEELEEAKKKLAQRL-----QEAEEAVEAVN--AKCS 1413
Cdd:TIGR00606  498 TLKKEVKSLQNE--KADLDRKLRKLDQEMEQ--LNHHTTTRTQMEMLTKDKMDKDEQIrkiksRHSDELTSLLGyfPNKK 573

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1414 SLEKTKHRLQNEI---EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES-------------QSELESSQKEARS 1477
Cdd:TIGR00606  574 QLEDWLHSKSKEInqtRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKlfdvcgsqdeesdLERLKEEIEKSSK 653

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1478 LSTELFKLKNAYEESLEHLET------------FKREnKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSAL 1545
Cdd:TIGR00606  654 QRAMLAGATAVYSQFITQLTDenqsccpvcqrvFQTE-AELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLA 732

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1546 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLA--EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDL 1623
Cdd:TIGR00606  733 PGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNdiEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQA 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1624 NEMEiqlshanrmAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA----VVEQTERS 1699
Cdd:TIGR00606  813 AKLQ---------GSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSeklqIGTNLQRR 883

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1700 RKLAEQeLIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQecrNAEEKAKKAITDAAMMAEELKK------- 1772
Cdd:TIGR00606  884 QQFEEQ-LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELIS---SKETSNKKAQDKVNDIKEKVKNihgymkd 959

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1773 -EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQialkggkkQLQKLEARVRELENELEAE--QKRNAESVKGMRKSERRIK 1849
Cdd:TIGR00606  960 iENKIQDGKDDYLKQKETELNTVNAQLEECEK--------HQEKINEDMRLMRQDIDTQkiQERWLQDNLTLRKRENELK 1031

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119586555  1850 ELtyqtEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRD 1927
Cdd:TIGR00606 1032 EV----EEELKQHLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFRDAEEKYRE 1105
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 841-1415 5.39e-14

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 77.91  E-value: 5.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE--------------QDNLADAEERCD 906
Cdd:pfam01576  455 KNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEeeakrnverqlstlQAQLSDMKKKLE 534

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   907 QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 986
Cdd:pfam01576  535 EDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEK 614

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   987 EIIAKLT------------KEKKALQEAHqqALDDLQaeeDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRK 1054
Cdd:pfam01576  615 AISARYAeerdraeaeareKETRALSLAR--ALEEAL---EAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRA 689

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1055 LEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE-DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 1133
Cdd:pfam01576  690 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFErDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAV 769

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1134 KLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA--------------------------TLQHEA 1187
Cdd:pfam01576  770 AAKKKLELDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEArasrdeilaqskesekklknleaellQLQEDL 849

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1188 TAAALRKKHADSVA-ELGEQIDN-------LQRVKQKLEKEKSEFKLELDDVTSNMEqIIKAKAANLEKMCRTLEDQMNE 1259
Cdd:pfam01576  850 AASERARRQAQQERdELADEIASgasgksaLQDEKRRLEARIAQLEEELEEEQSNTE-LLNDRLRKSTLQVEQLTTELAA 928

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1260 HRSKAEETQrsvndltSQRAKLQTENGELSRQLDEKEALI-SQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 1338
Cdd:pfam01576  929 ERSTSQKSE-------SARQQLERQNKELKAKLQEMEGTVkSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTE 1001

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555  1339 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYEtDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1415
Cdd:pfam01576 1002 KKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLE-EAEEEASRANAARRKLQRELDDATESNESMNREVSTL 1077
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1077-1924 5.95e-14

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 77.70  E-value: 5.95e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEleaertARAKVEKLRSDLSRELEEISERLEEAGGA 1156
Cdd:pfam02463  152 PERRLEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELK------LQELKLKEQAKKALEYYQLKEKLELEEEY 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1157 TSVQIEMnkKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1236
Cdd:pfam02463  226 LLYLDYL--KLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELL 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1237 Q------IIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT 1310
Cdd:pfam02463  304 KlerrkvDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLES 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1311 QQLEDLKRQLEEEvkaknaLAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA 1390
Cdd:pfam02463  384 ERLSSAAKLKEEE------LELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQE 457

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1391 KKKLAQRLQEAEEAVEAVNAKCsSLEKTKHRLQNEIEDLMVDVERSNAA---AAALDKKQRNFDKILAEWKQKYEESQSE 1467
Cdd:pfam02463  458 LKLLKDELELKKSEDLLKETQL-VKLQEQLELLLSRQKLEERSQKESKArsgLKVLLALIKDGVGGRIISAHGRLGDLGV 536

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1468 LESSQKEARSLST-ELFKLKNAYEESLEHLETFKRENKN----LQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ 1542
Cdd:pfam02463  537 AVENYKVAISTAViVEVSATADEVEERQKLVRALTELPLgarkLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEAD 616

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1543 SALEEAEASLEHEEGKILraqlefnqiKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 1622
Cdd:pfam02463  617 EDDKRAKVVEGILKDTEL---------TKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAES 687

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1623 LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV---ERRNNLLQAELEELRAVVEQTERS 1699
Cdd:pfam02463  688 ELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLlkqKIDEEEEEEEKSRLKKEEKEEEKS 767

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1700 RKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKA----ITDAAMMAEELKKEQD 1775
Cdd:pfam02463  768 ELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEekikEEELEELALELKEEQK 847

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1776 TSAHLE---RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT 1852
Cdd:pfam02463  848 LEKLAEeelERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEA 927

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119586555  1853 YQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1924
Cdd:pfam02463  928 EILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKER 999
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
900-1575 7.16e-14

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 77.65  E-value: 7.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  900 DAEERCDQLIKNKIQLEakvkEMNERLEDEEEmNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATenKVKNLT 979
Cdd:COG4913   222 DTFEAADALVEHFDDLE----RAHEALEDARE-QIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQR--RLELLE 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  980 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL-TKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD 1058
Cdd:COG4913   295 AELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAALGLP 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1059 LKLTQEsimDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIeeleeeleaertarAKVEKLRSD 1138
Cdd:COG4913   375 LPASAE---EFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEI--------------ASLERRKSN 437

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1139 LSRELEEISERLEEAGGATSVQ-------IEMnKKREAEFqkmrRDLEEATLQHEATAAALRKKHADSVAELGEQID--- 1208
Cdd:COG4913   438 IPARLLALRDALAEALGLDEAElpfvgelIEV-RPEEERW----RGAIERVLGGFALTLLVPPEHYAAALRWVNRLHlrg 512

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1209 --NLQRVKQKLEKEKSEF--------KLELDD--VTSNMEQIIkAKAANLEKmCRTLEDQMNEHRS-------KAEETQR 1269
Cdd:COG4913   513 rlVYERVRTGLPDPERPRldpdslagKLDFKPhpFRAWLEAEL-GRRFDYVC-VDSPEELRRHPRAitragqvKGNGTRH 590

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1270 SVNDLTSQRAKLQT--ENGelsRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQ 1347
Cdd:COG4913   591 EKDDRRRIRSRYVLgfDNR---AKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAE 667

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1348 yEEETEAKAELQRvLSKANSEVaqwrtkyetdaiqrtEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1427
Cdd:COG4913   668 -REIAELEAELER-LDASSDDL---------------AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELD 730

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1428 DLMVDVErsnaAAAALDKKQRNFDkiLAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNlq 1507
Cdd:COG4913   731 ELQDRLE----AAEDLARLELRAL--LEERFAAALGDAVERELRENLEERIDALRARLNRAEEELERAMRAFNREWPA-- 802

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555 1508 eEISDLTEQLGSsgktIHELEKVRKQLEAEKM-ELQSALEEAEASLEHEEGKILRAQL--EFNQIKAEIER 1575
Cdd:COG4913   803 -ETADLDADLES----LPEYLALLDRLEEDGLpEYEERFKELLNENSIEFVADLLSKLrrAIREIKERIDP 868
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 843-1600 8.48e-14

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 77.32  E-value: 8.48e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEM 922
Cdd:pfam02463  275 KEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAE 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   923 NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA 1002
Cdd:pfam02463  355 EEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEE 434

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1003 HQQALDDLQA--EEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERL 1080
Cdd:pfam02463  435 EEESIELKQGklTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLA 514

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1081 KKKDFELNALNARIEDEQALGSQLQKklKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQ 1160
Cdd:pfam02463  515 LIKDGVGGRIISAHGRLGDLGVAVEN--YKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLK 592

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1161 IEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE-KEKSEFKLELDDVTSNMEQII 1239
Cdd:pfam02463  593 SIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKgVSLEEGLAEKSEVKASLSELT 672

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1240 KAKAANLEKMCRTLEDQMNEHRSKAEETQrsvnDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ 1319
Cdd:pfam02463  673 KELLEIQELQEKAESELAKEEILRRQLEI----KKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEE 748

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1320 LEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSevaqwrtkyetdaiqRTEELEEAKKKLAQRLQ 1399
Cdd:pfam02463  749 EEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKL---------------KAQEEELRALEEELKEE 813

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1400 EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVErsnaAAAALDKKQRNFDKILAEWK------QKYEESQSELESSQK 1473
Cdd:pfam02463  814 AELLEEEQLLIEQEEKIKEEELEELALELKEEQKL----EKLAEEELERLEEEITKEELlqelllKEEELEEQKLKDELE 889

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1474 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLE 1553
Cdd:pfam02463  890 SKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAK 969

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*..
gi 119586555  1554 HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1600
Cdd:pfam02463  970 EELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETC 1016
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 880-1701 9.39e-14

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 77.19  E-value: 9.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   880 LLQEKNDLQLQVQAEQDNLADAEERC---DQLIKNKIQLEAK---VKEMNERLEDEEEMNAEltaKKRKLEDECSELKRD 953
Cdd:pfam12128  153 TLLGRERVELRSLARQFALCDSESPLrhiDKIAKAMHSKEGKfrdVKSMIVAILEDDGVVPP---KSRLNRQQVEHWIRD 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   954 IDdlelTLAKVEKEKHatenKVKNLTEEMAGLDEIIAKLTKEKKALQEaHQQALDDLQAEEDKvntltkAKVKLEQQVDD 1033
Cdd:pfam12128  230 IQ----AIAGIMKIRP----EFTKLQQEFNTLESAELRLSHLHFGYKS-DETLIASRQEERQE------TSAELNQLLRT 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1034 LEGSLeqekkvrmdlerakrklegdlkltQESIMDLENDKQQLDERLKKKDFELNALNARiedeqalgsqlqkKLKELQA 1113
Cdd:pfam12128  295 LDDQW------------------------KEKRDELNGELSAADAAVAKDRSELEALEDQ-------------HGAFLDA 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1114 RIEeleeeleaerTARAKVEKLRSdLSRELEEISERLE-EAGGATSVQIEMNKKREAEFQKMRRDL-----------EEA 1181
Cdd:pfam12128  338 DIE----------TAAADQEQLPS-WQSELENLEERLKaLTGKHQDVTAKYNRRRSKIKEQNNRDIagikdklakirEAR 406

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1182 TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAAnlekmcrtlEDQMNEHR 1261
Cdd:pfam12128  407 DRQLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLQLENF---------DERIERAR 477

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1262 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTrgkltytQQLEDLKRQL------------EEEVKAKNA 1329
Cdd:pfam12128  478 EEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQ-------SALDELELQLfpqagtllhflrKEAPDWEQS 550

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1330 LAHALQSAR-HDCDLLREQYEEETEAKAELQRV-LSKANSEVAQWrtkyetdaIQRTEELEEakkklaqRLQEAEEAVEA 1407
Cdd:pfam12128  551 IGKVISPELlHRTDLDPEVWDGSVGGELNLYGVkLDLKRIDVPEW--------AASEEELRE-------RLDKAEEALQS 615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1408 VNAKCSSLEKTKHRLQNEIEDLmvDVERSNAAAA---ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFK 1484
Cdd:pfam12128  616 AREKQAAAEEQLVQANGELEKA--SREETFARTAlknARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEAQLKQ 693

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1485 LKNAYEESLEHLETFKRENKN-----LQEEISDLTEQLGSSGKTIhelEKVRKQLEAEKMELQSALEEAEASLEHEEGKI 1559
Cdd:pfam12128  694 LDKKHQAWLEEQKEQKREARTekqayWQVVEGALDAQLALLKAAI---AARRSGAKAELKALETWYKRDLASLGVDPDVI 770

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1560 LRaqlefnqIKAEIeRKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRvkkKMEGDLNEMEIQLShanRMAAE 1639
Cdd:pfam12128  771 AK-------LKREI-RTLERKIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLS---NIERAISELQQQLA---RLIAD 836

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555  1640 AQKQVKSLQSLLK---DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE--ELRAVVEQTERSRK 1701
Cdd:pfam12128  837 TKLRRAKLEMERKaseKQQVRLSENLRGLRCEMSKLATLKEDANSEQAQGSigERLAQLEDLKLKRD 903
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1382-1927 1.66e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.26  E-value: 1.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1382 QRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKhrlqNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKy 1461
Cdd:PRK03918  200 KELEEVLREINEISSELPELREELEKLEKEVKELEELK----EEIEELEKELESLEGSKRKLEEKIRELEERIEELKKE- 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1462 eesqselESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVR---KQLEAEK 1538
Cdd:PRK03918  275 -------IEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEerlEELKKKL 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1539 MELQSALEEAEASLE-HEEGKILRAQLEfnQIKAEIE----RKLAEKDEEMEQAK---RNHLRVVDSLQTSLDAETRSRN 1610
Cdd:PRK03918  348 KELEKRLEELEERHElYEEAKAKKEELE--RLKKRLTgltpEKLEKELEELEKAKeeiEEEISKITARIGELKKEIKELK 425

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1611 EALRVKKKMEGD--LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLkENIAIVERRNNLLQAELEE 1688
Cdd:PRK03918  426 KAIEELKKAKGKcpVCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELREL-EKVLKKESELIKLKELAEQ 504

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1689 LRAVVEQTErsrKLAEQELIETSERVQLLHSQNTslinqkkKMDADLSQLQTEVEEAvqecrNAEEKAKKAITDAAMMAE 1768
Cdd:PRK03918  505 LKELEEKLK---KYNLEELEKKAEEYEKLKEKLI-------KLKGEIKSLKKELEKL-----EELKKKLAELEKKLDELE 569

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1769 ELKKEQdtsahLERMKKNMEQTIKDLQHRLDEAEQ-----IALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRK 1843
Cdd:PRK03918  570 EELAEL-----LKELEELGFESVEELEERLKELEPfyneyLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEE 644

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1844 SERRIKELTYQ-TEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD---IAESQVN 1919
Cdd:PRK03918  645 LRKELEELEKKySEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEkleKALERVE 724


                  ....*...
gi 119586555 1920 KLRAKSRD 1927
Cdd:PRK03918  725 ELREKVKK 732
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1174-1872 1.74e-13

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 76.11  E-value: 1.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1174 MRRDLEEATLQHEATAAAlrKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELddvtsnmeqiIKAKAANLEKMCRTL 1253
Cdd:COG4913   240 AHEALEDAREQIELLEPI--RELAERYAAARERLAELEYLRAALRLWFAQRRLEL----------LEAELEELRAELARL 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1254 EDQMNEHRSKAEETQRSVNDLTSQRAklqtENGelsrqldekealisqltrgkltyTQQLEDLKRQLEEEVKAKNALAHA 1333
Cdd:COG4913   308 EAELERLEARLDALREELDELEAQIR----GNG-----------------------GDRLEQLEREIERLERELEERERR 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1334 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE-----------AE 1402
Cdd:COG4913   361 RARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEiaslerrksniPA 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1403 EAVEAVNAKCSSLEKTKHRL----------------QNEIE--------DLMVDVERSNAAAAALDK---KQR-NFDKIl 1454
Cdd:COG4913   441 RLLALRDALAEALGLDEAELpfvgelievrpeeerwRGAIErvlggfalTLLVPPEHYAAALRWVNRlhlRGRlVYERV- 519

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1455 aewkqkyEESQSELESSQKEARSLSTELFKLKNAYEESLEHL-------------ETFKRENKNlqeeisdLTEQ-LGSS 1520
Cdd:COG4913   520 -------RTGLPDPERPRLDPDSLAGKLDFKPHPFRAWLEAElgrrfdyvcvdspEELRRHPRA-------ITRAgQVKG 585

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1521 GKTIHELEKVRKqleaekmeLQSAL---EEAEASLEHEEGKILRAQLEFNQIKAEIErKLAEKDEEMEQAKRNHLRVVDS 1597
Cdd:COG4913   586 NGTRHEKDDRRR--------IRSRYvlgFDNRAKLAALEAELAELEEELAEAEERLE-ALEAELDALQERREALQRLAEY 656

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1598 LQTSLDAETRSRnealrvkkkmegDLNEMEIQLSHANrmaaEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVER 1677
Cdd:COG4913   657 SWDEIDVASAER------------EIAELEAELERLD----ASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEK 720

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1678 RNNLLQAELEELRAVVEQTERSRKLAEQELIEtsERVQLLHSQNT------SLINQKKKMDADLSQLQTEVEEAVQE-CR 1750
Cdd:COG4913   721 ELEQAEEELDELQDRLEAAEDLARLELRALLE--ERFAAALGDAVerelreNLEERIDALRARLNRAEEELERAMRAfNR 798

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1751 NAEEKAKKAITDAAMMAEELK-----KEQDTSAHLERMK----KNMEQTIKDLQHRLDEAEQIAlkggKKQLQKLEARVR 1821
Cdd:COG4913   799 EWPAETADLDADLESLPEYLAlldrlEEDGLPEYEERFKellnENSIEFVADLLSKLRRAIREI----KERIDPLNDSLK 874

                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 119586555 1822 ELE-NE-----LEAEQKRNAEsVKGMRKSERRIKELTYQTEED--RKNLLRLQDLVDKL 1872
Cdd:COG4913   875 RIPfGPgrylrLEARPRPDPE-VREFRQELRAVTSGASLFDEElsEARFAALKRLIERL 932
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
843-1386 2.10e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.87  E-value: 2.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  843 AEREKEMASMKEEFTRLKEaLEKSEARRKELEEKMVSLLQEKNDLQlqvqaeqdnladaeercdqliKNKIQLEAKVKEM 922
Cdd:PRK03918  269 EELKKEIEELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELREIE---------------------KRLSRLEEEINGI 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  923 NERLEDEEEMNAELtakkRKLEDECSELKRDIDDLEltlakvekEKHATENKVKNLTEEMAGLDEIIAKLTKEK--KALQ 1000
Cdd:PRK03918  327 EERIKELEEKEERL----EELKKKLKELEKRLEELE--------ERHELYEEAKAKKEELERLKKRLTGLTPEKleKELE 394

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1001 EAHQQALDdlqaEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD-----LKLTQESIMDLENDKQQ 1075
Cdd:PRK03918  395 ELEKAKEE----IEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEhrkelLEEYTAELKRIEKELKE 470

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1076 LDERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARIEELEeeleaertarakVEKLRSDlSRELEEISERLEEA 1153
Cdd:PRK03918  471 IEEKERKLRKELRELEKVLKKESELIKLKElaEQLKELEEKLKKYN------------LEELEKK-AEEYEKLKEKLIKL 537

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1154 GGATSVqIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKhadsVAELG-EQIDNLQRVKQKLEKEKSEFkLELDDVT 1232
Cdd:PRK03918  538 KGEIKS-LKKELEKLEELKKKLAELEKKLDELEEELAELLKE----LEELGfESVEELEERLKELEPFYNEY-LELKDAE 611

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1233 SNMEqIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTS-----QRAKLQTENGELSRQLDEKEALISQLTRGKL 1307
Cdd:PRK03918  612 KELE-REEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKkyseeEYEELREEYLELSRELAGLRAELEELEKRRE 690

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1308 TYTQQLEDLKRQLEEEVKAKNALaHALQSARHDCDLLREQY-----EEETEAKAELQRVLSKANSEVAQwrTKYETDAIQ 1382
Cdd:PRK03918  691 EIKKTLEKLKEELEEREKAKKEL-EKLEKALERVEELREKVkkykaLLKERALSKVGEIASEIFEELTE--GKYSGVRVK 767


                  ....
gi 119586555 1383 RTEE 1386
Cdd:PRK03918  768 AEEN 771
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1312-1873 2.64e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 75.46  E-value: 2.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1312 QLEDLKRQLEE-EVKAKNALAHALQSARHDCDLLREQYEEETEAKAElqrVLSKANSEVAQWRTKYEtdaiqRTEELEEA 1390
Cdd:PRK02224  188 SLDQLKAQIEEkEEKDLHERLNGLESELAELDEEIERYEEQREQARE---TRDEADEVLEEHEERRE-----ELETLEAE 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1391 KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1470
Cdd:PRK02224  260 IEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQA 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1471 SQKEARSLS--------------TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA 1536
Cdd:PRK02224  340 HNEEAESLRedaddleeraeelrEEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELRE 419

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1537 EKMELQSALEEAEASLEHEEGKIlraqlefnqikAEIERKLAE-KDEEMEQAkrnhlrVVDSLQTSLDAETRSRNEALRV 1615
Cdd:PRK02224  420 ERDELREREAELEATLRTARERV-----------EEAEALLEAgKCPECGQP------VEGSPHVETIEEDRERVEELEA 482

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1616 K-KKMEGDLNEMEIQLSHANRmAAEAQKQVKSLQSllkdtqiQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1694
Cdd:PRK02224  483 ElEDLEEEVEEVEERLERAED-LVEAEDRIERLEE-------RREDLEELIAERRETIEEKRERAEELRERAAELEAEAE 554

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1695 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDaDLSQLQTEVEEAVQECRNAEEKAKkaitDAAMMAEELKkeq 1774
Cdd:PRK02224  555 EKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLE-RIRTLLAAIADAEDEIERLREKRE----ALAELNDERR--- 626

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1775 dtsahlERMKKNMEQtIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEaEQKRNAESVKGMRKSErrIKELtyq 1854
Cdd:PRK02224  627 ------ERLAEKRER-KRELEAEFDEARIEEAREDKERAEEYLEQVEEKLDELR-EERDDLQAEIGAVENE--LEEL--- 693

                         570
                  ....*....|....*....
gi 119586555 1855 tEEDRKNLLRLQDLVDKLQ 1873
Cdd:PRK02224  694 -EELRERREALENRVEALE 711
PTZ00121 PTZ00121
MAEBL; Provisional
 1254-1926 4.13e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 75.18  E-value: 4.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1254 EDQMNEHRSKAEETQRSVNDltsQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKrqLEEEVKAKNALAHA 1333
Cdd:PTZ00121 1050 EDIDGNHEGKAEAKAHVGQD---EGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGK--AEEARKAEEAKKKA 1124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1334 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK----KLAQRLQEAEEAVEAVN 1409
Cdd:PTZ00121 1125 EDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKaeevRKAEELRKAEDARKAEA 1204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1410 AKCSSLEKT-----KHRLQNEIEDLM-VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELF 1483
Cdd:PTZ00121 1205 ARKAEEERKaeearKAEDAKKAEAVKkAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELK 1284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1484 KLknayEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQ 1563
Cdd:PTZ00121 1285 KA----EEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAE 1360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1564 lefnqiKAEIERKLAEKDEEMEQAKRNHLRVvdslqtslDAETRSRNEALRvKKKMEGDLNEMEIQLSHANRMAAEAQKQ 1643
Cdd:PTZ00121 1361 ------AAEEKAEAAEKKKEEAKKKADAAKK--------KAEEKKKADEAK-KKAEEDKKKADELKKAAAAKKKADEAKK 1425

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1644 VKSLQSLLKDTQIQLDDAVRAnDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1723
Cdd:PTZ00121 1426 KAEEKKKADEAKKKAEEAKKA-DEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKK 1504

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1724 LINQKKKMDadlSQLQTEVEEAVQECRNAEEKAKkaiTDAAMMAEELKKEQDTSAhLERMKKNMEQTIKDLQHRLDEAEQ 1803
Cdd:PTZ00121 1505 AAEAKKKAD---EAKKAEEAKKADEAKKAEEAKK---ADEAKKAEEKKKADELKK-AEELKKAEEKKKAEEAKKAEEDKN 1577

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1804 IALKGGKKQLQKLEARVRELENELEAEQKRNAESVKgmRKSERRIK-ELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQ 1882
Cdd:PTZ00121 1578 MALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAK--KAEEAKIKaEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKA 1655

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 119586555 1883 AEE----AEEQANTNLSKFRKVQhELDEAEERADIAESQVNKLRAKSR 1926
Cdd:PTZ00121 1656 EEEnkikAAEEAKKAEEDKKKAE-EAKKAEEDEKKAAEALKKEAEEAK 1702
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 831-1328 1.02e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 73.52  E-value: 1.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   831 KLYFKIKPLLKSA-EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADaeercdqlI 909
Cdd:TIGR04523  121 KLEVELNKLEKQKkENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDK--------I 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   910 KNKI-QLEAKVKEMNERLEDEEEMNAELT---AKKRKLEDECSELKRDIDDLELTLAKVE-------------------- 965
Cdd:TIGR04523  193 KNKLlKLELLLSNLKKKIQKNKSLESQISelkKQNNQLKDNIEKKQQEINEKTTEISNTQtqlnqlkdeqnkikkqlsek 272

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   966 -KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKalQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKV 1044
Cdd:TIGR04523  273 qKELEQNNKKIKELEKQLNQLKSEISDLNNQKE--QDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKE 350

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1045 RMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Cdd:TIGR04523  351 LTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIER 430

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL------RKKHAD 1198
Cdd:TIGR04523  431 LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELkklneeKKELEE 510

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1199 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIikakaaNLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQR 1278
Cdd:TIGR04523  511 KVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKD------DFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQ 584

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 119586555  1279 AKLQTEngelsrqLDEKEALISQLTRGKLTYTQQLEDLKRQLeEEVKAKN 1328
Cdd:TIGR04523  585 EEKQEL-------IDQKEKEKKDLIKEIEEKEKKISSLEKEL-EKAKKEN 626
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
860-1209 1.32e-12

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 73.41  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  860 KEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDnLADAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAEL 936
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQE-RREALQRLAEYSWDEIdvaSAEREIAELEAELERLDASSDDL 687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  937 takkRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEmagLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK 1016
Cdd:COG4913   688 ----AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEE---LDELQDRLEAAEDLARLELRALLEERFAAALG 760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1017 VNTLTKAKVKLEQQVDDLEGSLEQ-EKKVRMDLERAKRKLEGDLKLTQESIMDLEndkqqlderlkkkdfELNALNARIE 1095
Cdd:COG4913   761 DAVERELRENLEERIDALRARLNRaEEELERAMRAFNREWPAETADLDADLESLP---------------EYLALLDRLE 825

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1096 DEqalgsqlqkKLKELQARIEELEEeleaeRTARAKVEKLRSDLSRELEEISERLEEA---------GGATSVQIEMNKK 1166
Cdd:COG4913   826 ED---------GLPEYEERFKELLN-----ENSIEFVADLLSKLRRAIREIKERIDPLndslkripfGPGRYLRLEARPR 891

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 119586555 1167 REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1209
Cdd:COG4913   892 PDPEVREFRQELRAVTSGASLFDEELSEARFAALKRLIERLRS 934
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1488-1925 1.58e-12

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 73.15  E-value: 1.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1488 AYEESLEHLETfkrenknLQEEISDLTEqlgssgkTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1567
Cdd:PRK02224  245 EHEERREELET-------LEAEIEDLRE-------TIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAE 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1568 QIKAEIErKLAEKDEEMEQAKRNHLrvVDSLQTSLDAET--------RSRNEALRVK-KKMEGDLNEMEIQLSHANRMAA 1638
Cdd:PRK02224  311 AVEARRE-ELEDRDEELRDRLEECR--VAAQAHNEEAESlredaddlEERAEELREEaAELESELEEAREAVEDRREEIE 387

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1639 EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR---KLAE--QElIETSER 1713
Cdd:PRK02224  388 ELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLeagKCPEcgQP-VEGSPH 466

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1714 VQLLHSQNtsliNQKKKMDADLSQLQTEVEEAvqecrnaEEKAKKAitdaammaEELKKEQDTSAHLERMKKNMEQTIKD 1793
Cdd:PRK02224  467 VETIEEDR----ERVEELEAELEDLEEEVEEV-------EERLERA--------EDLVEAEDRIERLEERREDLEELIAE 527

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1794 LQHRLDEAEQialkggkkQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEE---DRKNLLRLQDLVD 1870
Cdd:PRK02224  528 RRETIEEKRE--------RAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAElkeRIESLERIRTLLA 599

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555 1871 KLQLKVKAYKRQAEEAEEQANTN------LSKFRKVQHELDEAEERADIAESQVNKLRAKS 1925
Cdd:PRK02224  600 AIADAEDEIERLREKREALAELNderrerLAEKRERKRELEAEFDEARIEEAREDKERAEE 660
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 1489-1829 3.86e-12

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 71.26  E-value: 3.86e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1489 YEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQsaleEAEASLEHEEGKILRAQLEFNQ 1568
Cdd:pfam05622  140 YKKKLEDLGDLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQVQ----ELHGKLSEESKKADKLEFEYKK 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1569 IKA-------EIERKLAEKD---EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAA 1638
Cdd:pfam05622  216 LEEklealqkEKERLIIERDtlrETNEELRCAQLQQAELSQADALLSPSSDPGDNLAAEIMPAEIREKLIRLQHENKMLR 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1639 EAQKQvkSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRavveqtersRKLAEQElietservqllh 1718
Cdd:pfam05622  296 LGQEG--SYRERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQ---------KALQEQG------------ 352

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1719 SQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL-----KKEQDTSAHLERMKKNMEQ---T 1790
Cdd:pfam05622  353 SKAEDSSLLKQKLEEHLEKLHEAQSELQKKKEQIEELEPKQDSNLAQKIDELqealrKKDEDMKAMEERYKKYVEKaksV 432

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 119586555  1791 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1829
Cdd:pfam05622  433 IKTLDPKQNPASPPEIQALKNQLLEKDKKIEHLERDFEK 471
PTZ00121 PTZ00121
MAEBL; Provisional
 835-1512 4.11e-12

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 72.10  E-value: 4.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  835 KIKPLLKSAEREKEMAsmKEEFTRLKEALEKSEARRKELEEKmvsllqekndlqlqvqaeqdnladaeercdqliKNKIQ 914
Cdd:PTZ00121 1316 KADEAKKKAEEAKKKA--DAAKKKAEEAKKAAEAAKAEAEAA---------------------------------ADEAE 1360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  915 LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRdiddleltlaKVEKEKHATEnKVKNLTEEMAGLDEIIAKLTK 994
Cdd:PTZ00121 1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKK----------KAEEDKKKAD-ELKKAAAAKKKADEAKKKAEE 1429

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  995 EKKAlQEAHQQALDDLQAEEdkvntlTKAKVKLEQQVDDLEGSLEQEKKVrmdlERAKRKLEgDLKLTQESIMDLENDKQ 1074
Cdd:PTZ00121 1430 KKKA-DEAKKKAEEAKKADE------AKKKAEEAKKAEEAKKKAEEAKKA----DEAKKKAE-EAKKADEAKKKAEEAKK 1497

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1075 QLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQArieeleeeleaeRTARAKVEKLRSDLSRELEEISERLEEAg 1154
Cdd:PTZ00121 1498 KADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA------------DEAKKAEEKKKADELKKAEELKKAEEKK- 1564

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1155 gatsvQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEfklelDDVTSN 1234
Cdd:PTZ00121 1565 -----KAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKA-----EEEKKK 1634

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1235 MEQIIKAKAANLEKMcrtledqmnEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLE 1314
Cdd:PTZ00121 1635 VEQLKKKEAEEKKKA---------EELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE 1705

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1315 DLKRQLEEEVKAKNALAHALQSARHDCDLLREQyEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL-----EE 1389
Cdd:PTZ00121 1706 ELKKKEAEEKKKAEELKKAEEENKIKAEEAKKE-AEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKeavieEE 1784

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1390 AKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKilAEWKQKYEESQSELE 1469
Cdd:PTZ00121 1785 LDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEAD--AFEKHKFNKNNENGE 1862

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|...
gi 119586555 1470 SSQKEARSlSTELFKLKNAYEESLEHLETFKRENKNLQEEISD 1512
Cdd:PTZ00121 1863 DGNKEADF-NKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPN 1904
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 914-1859 1.59e-11

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 70.08  E-value: 1.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   914 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKekhatenkvknLTEEMAGLDEIIAKLT 993
Cdd:TIGR00606  214 QYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMK-----------LDNEIKALKSRKKQME 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   994 KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVK-LEQQVDDLEGSLEQEKKVRMDLERAKRKLEgdlklTQESIMDLEND 1072
Cdd:TIGR00606  283 KDNSELELKMEKVFQGTDEQLNDLYHNHQRTVReKERELVDCQRELEKLNKERRLLNQEKTELL-----VEQGRLQLQAD 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1073 KQQldERLKKKDFELNALNARIE-DEQALGSQLQKKLKelQARIEELEEELEAERTARAKVEKLRSDLS---RELEEISE 1148
Cdd:TIGR00606  358 RHQ--EHIRARDSLIQSLATRLElDGFERGPFSERQIK--NFHTLVIERQEDEAKTAAQLCADLQSKERlkqEQADEIRD 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1149 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATlqheataaalrkKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEL 1228
Cdd:TIGR00606  434 EKKGLGRTIELKKEILEKKQEELKFVIKELQQLE------------GSSDRILELDQELRKAERELSKAEKNSLTETLKK 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1229 DDVTSNMEQ--IIKAKAANLEKMcrtleDQMNEHRSKAEETQRSVNDLTSQRAKLQTENgelSRQLDEkeaLISQLtrGK 1306
Cdd:TIGR00606  502 EVKSLQNEKadLDRKLRKLDQEM-----EQLNHHTTTRTQMEMLTKDKMDKDEQIRKIK---SRHSDE---LTSLL--GY 568

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1307 LTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTkYETDAIQRTEE 1386
Cdd:TIGR00606  569 FPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQD-EESDLERLKEE 647

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1387 LEEAKKKLA----------QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL----MVDVERSNAAAAALDKKQRNFDK 1452
Cdd:TIGR00606  648 IEKSSKQRAmlagatavysQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLqsklRLAPDKLKSTESELKKKEKRRDE 727

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1453 IL--AEWKQKYEESQSELESSQKEA-RSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT--EQLgssgktIHEL 1527
Cdd:TIGR00606  728 MLglAPGRQSIIDLKEKEIPELRNKlQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTimERF------QMEL 801

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1528 EKVRKQLEAEKMELQSAleEAEASLEHEEGKILRAQLEFNQIKAEIErkLAEKDEEMEQAKRNHLRvvdSLQTSLDAETR 1607
Cdd:TIGR00606  802 KDVERKIAQQAAKLQGS--DLDRTVQQVNQEKQEKQHELDTVVSKIE--LNRKLIQDQQEQIQHLK---SKTNELKSEKL 874

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1608 SRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANddlkeniaivERRNNLLQAELE 1687
Cdd:TIGR00606  875 QIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSK----------ETSNKKAQDKVN 944

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1688 ELRAVVEQTERSRKLAEQELIETSERvqllhsqntslinQKKKMDADLSQLQTEVEEAVQECRNAEE--KAKKAITDAAM 1765
Cdd:TIGR00606  945 DIKEKVKNIHGYMKDIENKIQDGKDD-------------YLKQKETELNTVNAQLEECEKHQEKINEdmRLMRQDIDTQK 1011

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1766 MAEELKKEQDTSAHLERMKKNMEQTIKdlQHrLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSE 1845
Cdd:TIGR00606 1012 IQERWLQDNLTLRKRENELKEVEEELK--QH-LKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFK 1088

                          970
                   ....*....|....
gi 119586555  1846 RRIKELTYQTEEDR 1859
Cdd:TIGR00606 1089 KELREPQFRDAEEK 1102
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 861-1659 1.84e-11

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 69.61  E-value: 1.84e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   861 EALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDnlaDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAK- 939
Cdd:TIGR00618  173 FPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTL---CTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKr 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   940 -----KRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKnlteemagldeiIAKLTKEKKALQEAHQQALDDLQAEE 1014
Cdd:TIGR00618  250 eaqeeQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARK------------AAPLAAHIKAVTQIEQQAQRIHTELQ 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1015 DKVNTLTKAKVKLEQQVDDlEGSLEQEKKVRMDLERAKRKLEgDLKLTQESIMDLENDKQQLDERLKKKDFELNALnari 1094
Cdd:TIGR00618  318 SKMRSRAKLLMKRAAHVKQ-QSSIEEQRRLLQTLHSQEIHIR-DAHEVATSIREISCQQHTLTQHIHTLQQQKTTL---- 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1095 EDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKlrsdlSRELEEISERLEEAGGATSVQIEmnKKREAEFQKM 1174
Cdd:TIGR00618  392 TQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKK-----QQELQQRYAELCAAAITCTAQCE--KLEKIHLQES 464

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1175 RRDLEEATlQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDvtsnmeqiikakAANLEKMCRTLE 1254
Cdd:TIGR00618  465 AQSLKERE-QQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQD------------IDNPGPLTRRMQ 531

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1255 DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRgkltYTQQLEDLkRQLEEEVKaknalahal 1334
Cdd:TIGR00618  532 RGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNR----SKEDIPNL-QNITVRLQ--------- 597

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1335 qsarhdcDLLREQYEEETEAKAELQRVLSKANSEVAqwrtKYETDAIQRTEELEEAKKKLAqrlqeaeeaveavnakcss 1414
Cdd:TIGR00618  598 -------DLTEKLSEAEDMLACEQHALLRKLQPEQD----LQDVRLHLQQCSQELALKLTA------------------- 647

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1415 lektkhrLQNEIEDLMVDVERSNAAAAALDKKQRnfdkilaewkqkyeesqselessqkeARSLSTELFKLKNAYEESLE 1494
Cdd:TIGR00618  648 -------LHALQLTLTQERVREHALSIRVLPKEL--------------------------LASRQLALQKMQSEKEQLTY 694

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1495 HLETFKRENKNLQEEIsdltEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1574
Cdd:TIGR00618  695 WKEMLAQCQTLLRELE----THIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEV 770

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1575 RKLAEKDEEMEQAKRNHLRVVDSLQTSLdAETRSRNEALRVKKKMEGDLNEMEIQLshanrmAAEAQKQVKSLQSLLKDT 1654
Cdd:TIGR00618  771 TAALQTGAELSHLAAEIQFFNRLREEDT-HLLKTLEAEIGQEIPSDEDILNLQCET------LVQEEEQFLSRLEEKSAT 843


                   ....*
gi 119586555  1655 QIQLD 1659
Cdd:TIGR00618  844 LGEIT 848
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1311-1848 2.60e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 69.17  E-value: 2.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1311 QQLEDLKRQLEEEVKAKNALAHALQSArhdcdllrEQYEEETEAKAELQRVLSKANSEVAQwrTKYETdAIQRTEELEEA 1390
Cdd:COG4913   235 DDLERAHEALEDAREQIELLEPIRELA--------ERYAAARERLAELEYLRAALRLWFAQ--RRLEL-LEAELEELRAE 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1391 KKKLAQRLQEAEEAVEAVNAKCSSLE--------KTKHRLQNEIEDLMVDVERSNAAAAALDKKQRN-----------FD 1451
Cdd:COG4913   304 LARLEAELERLEARLDALREELDELEaqirgnggDRLEQLEREIERLERELEERERRRARLEALLAAlglplpasaeeFA 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1452 KILAEWKQkyeesqselessqkEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIsdltEQLGSSGKTI-HELEKV 1530
Cdd:COG4913   384 ALRAEAAA--------------LLEALEEELEALEEALAEAEAALRDLRRELRELEAEI----ASLERRKSNIpARLLAL 445

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1531 RKQLE-------------AEKMEL-------QSALEEA---------------EASLEHEEGKILRAQLEFNQIKAeier 1575
Cdd:COG4913   446 RDALAealgldeaelpfvGELIEVrpeeerwRGAIERVlggfaltllvppehyAAALRWVNRLHLRGRLVYERVRT---- 521

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1576 klAEKDEEMEQAKRNHL-RVVDS----LQTSLDAETRSRNEALRVkkkmegdlnEMEIQLSHAnRMAAEAQKQVKSLQSL 1650
Cdd:COG4913   522 --GLPDPERPRLDPDSLaGKLDFkphpFRAWLEAELGRRFDYVCV---------DSPEELRRH-PRAITRAGQVKGNGTR 589

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1651 L-KDTQIQLD-------DAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAE--QELIETSERVQLLHSQ 1720
Cdd:COG4913   590 HeKDDRRRIRsryvlgfDNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQrlAEYSWDEIDVASAERE 669

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1721 NTSLINQKKKMDA---DLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELkkeqdtsahlermkKNMEQTIKDLQHR 1797
Cdd:COG4913   670 IAELEAELERLDAssdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKEL--------------EQAEEELDELQDR 735

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555 1798 LDEAEQIALKGGKKQLQKL------EARVRELENELEAEQKRNAESvkgMRKSERRI 1848
Cdd:COG4913   736 LEAAEDLARLELRALLEERfaaalgDAVERELRENLEERIDALRAR---LNRAEEEL 789
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
840-1256 2.93e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 68.64  E-value: 2.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  840 LKSAERE-KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD--NLADAEERCDQLIKNKIQLE 916
Cdd:COG4717    73 LKELEEElKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLyqELEALEAELAELPERLEELE 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  917 AKVKEMNERLEDEEEMNAELTAKKRKLEDEC-----------SELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 985
Cdd:COG4717   153 ERLEELRELEEELEELEAELAELQEELEELLeqlslateeelQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQL 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  986 DEIIAKLTKEKKALQE-----------AHQQALDDLQAEEDKV---------------NTLTKAKVKLEQQVDDLEGSLE 1039
Cdd:COG4717   233 ENELEAAALEERLKEArlllliaaallALLGLGGSLLSLILTIagvlflvlgllallfLLLAREKASLGKEAEELQALPA 312

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1040 QEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKkdfelnalnARIEDEQALGSQLQKKLKELQARIEELE 1119
Cdd:COG4717   313 LEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLRE---------AEELEEELQLEELEQEIAALLAEAGVED 383

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1120 EELEAertARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR--EAEFQKMRRDLEEATLQHEataaALRKKHA 1197
Cdd:COG4717   384 EEELR---AALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEelEEELEELEEELEELEEELE----ELREELA 456

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555 1198 DSVAELG--EQIDNLQRVKQKLEKEKSEFKLELDDVtsnmeQIIKAKAANLEKMCRTLEDQ 1256
Cdd:COG4717   457 ELEAELEqlEEDGELAELLQELEELKAELRELAEEW-----AALKLALELLEEAREEYREE 512
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1474-1932 2.97e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 68.79  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1474 EARSLSTELFKLKNAYEESLEhletfKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEasLE 1553
Cdd:COG4913   226 AADALVEHFDDLERAHEALED-----AREQIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAE--LE 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1554 HEEGKILRAQLEFNQIKAEIERkLAEKDEEMEQAKRNH-LRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 1632
Cdd:COG4913   299 ELRAELARLEAELERLEARLDA-LREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPA 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1633 A----NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEN-------IAIVERRNNLLQAELEELRAVVEqteRSRK 1701
Cdd:COG4913   378 SaeefAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRElreleaeIASLERRKSNIPARLLALRDALA---EALG 454

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1702 LAEQ------ELIETS----------ERVqlLHSQNTSL-------------INQKK----------------------- 1729
Cdd:COG4913   455 LDEAelpfvgELIEVRpeeerwrgaiERV--LGGFALTLlvppehyaaalrwVNRLHlrgrlvyervrtglpdperprld 532

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1730 ------KMDADLSQLQTEVEEAVQE------CRNAEE--KAKKAITDAAMMAeelkkeQDTSAHlermkknmeqtIKDLQ 1795
Cdd:COG4913   533 pdslagKLDFKPHPFRAWLEAELGRrfdyvcVDSPEElrRHPRAITRAGQVK------GNGTRH-----------EKDDR 595

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1796 HRLDEAEQIalkGG--KKQLQKLEARVRELENELEAEQKRnaesvkgMRKSERRIKELtyqteEDRKNLLRLQDLVDKLQ 1873
Cdd:COG4913   596 RRIRSRYVL---GFdnRAKLAALEAELAELEEELAEAEER-------LEALEAELDAL-----QERREALQRLAEYSWDE 660

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119586555 1874 LKVKAYKRQAEEAEEQ---ANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKR 1932
Cdd:COG4913   661 IDVASAEREIAELEAElerLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKEL 722
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
851-1429 3.35e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 68.79  E-value: 3.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  851 SMKEEFTRLKEA---LEKSEARRK---ELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI-QLEAKVKEMN 923
Cdd:COG4913   229 ALVEHFDDLERAheaLEDAREQIEllePIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELeELRAELARLE 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  924 ERLEDEEEMNAELTAKKRKLEDECSELK-RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA 1002
Cdd:COG4913   309 AELERLEARLDALREELDELEAQIRGNGgDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAE 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1003 HQQALDDLQAEEDKV-NTLTKAKVKLEQQVDDLEgSLEQE------KKVRMD--LERAKRKLEGDLKLTQESIM---DLe 1070
Cdd:COG4913   389 AAALLEALEEELEALeEALAEAEAALRDLRRELR-ELEAEiaslerRKSNIParLLALRDALAEALGLDEAELPfvgEL- 466

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1071 ndkqqLDERLKKKDFElNALnariedEQALGSQ----L--QKKLKE---------LQARIEELEEELEAERTARAK---- 1131
Cdd:COG4913   467 -----IEVRPEEERWR-GAI------ERVLGGFaltlLvpPEHYAAalrwvnrlhLRGRLVYERVRTGLPDPERPRldpd 534

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1132 --VEKLRSDLSRELEEISERLEEAGGATSV-----------------QIEMNKKReaeFQK-MRRDLEE----------- 1180
Cdd:COG4913   535 slAGKLDFKPHPFRAWLEAELGRRFDYVCVdspeelrrhpraitragQVKGNGTR---HEKdDRRRIRSryvlgfdnrak 611

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1181 -ATLQHEATAAALRKKHADS-VAELGEQIDNLQRVKQKLEKEKSEFKLELD------DVTSNMEQIIKAKAANLEkmCRT 1252
Cdd:COG4913   612 lAALEAELAELEEELAEAEErLEALEAELDALQERREALQRLAEYSWDEIDvasaerEIAELEAELERLDASSDD--LAA 689

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1253 LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT-RGKLTYTQQLEDLKRQLEEEvKAKNALA 1331
Cdd:COG4913   690 LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEdLARLELRALLEERFAAALGD-AVERELR 768

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1332 HALQSARHDCDLLREQYEEETEAKaeLQRVLSKANSEVAQWRTKYET----DAI---QRTEELEEAKKKLAQRLQEAEEa 1404
Cdd:COG4913   769 ENLEERIDALRARLNRAEEELERA--MRAFNREWPAETADLDADLESlpeyLALldrLEEDGLPEYEERFKELLNENSI- 845

                         650       660
                  ....*....|....*....|....*
gi 119586555 1405 vEAVNAKCSSLEKTKHRLQNEIEDL 1429
Cdd:COG4913   846 -EFVADLLSKLRRAIREIKERIDPL 869
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
843-1301 4.04e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 68.53  E-value: 4.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKM-------VSLLQEKNDLQLQVQAEQDNLAD-------AEERCDQL 908
Cdd:PRK02224  268 AETEREREELAEEVRDLRERLEELEEERDDLLAEAglddadaEAVEARREELEDRDEELRDRLEEcrvaaqaHNEEAESL 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  909 IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEI 988
Cdd:PRK02224  348 REDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELRER 427

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  989 IAKLTKEKKALQEAHQQALDDLQA---------------------EEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRmD 1047
Cdd:PRK02224  428 EAELEATLRTARERVEEAEALLEAgkcpecgqpvegsphvetieeDRERVEELEAELEDLEEEVEEVEERLERAEDLV-E 506

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT 1127
Cdd:PRK02224  507 AEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKE 586

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1128 ARAKVEKLRSDLSrELEEISERLEEAGGATSVQIEMNKKRE---AEFQKMRRDLEEATLQHEATAAALRKKHADS-VAEL 1203
Cdd:PRK02224  587 RIESLERIRTLLA-AIADAEDEIERLREKREALAELNDERRerlAEKRERKRELEAEFDEARIEEAREDKERAEEyLEQV 665

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSnmeqiIKAKAANLEKMCRTLEDQMNEhrskAEETQRSVNDLtsqRAKLQT 1283
Cdd:PRK02224  666 EEKLDELREERDDLQAEIGAVENELEELEE-----LRERREALENRVEALEALYDE----AEELESMYGDL---RAELRQ 733

                         490
                  ....*....|....*....
gi 119586555 1284 EN-GELSRQLDEKEALISQ 1301
Cdd:PRK02224  734 RNvETLERMLNETFDLVYQ 752
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 901-1140 4.26e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 67.10  E-value: 4.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  901 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTE 980
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  981 EMAGLDEIIAKLTKekkALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Cdd:COG4942    98 ELEAQKEELAELLR---ALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIE--ELEEELEAERTARAKVEKLRSD 1138
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIArlEAEAAAAAERTPAAGFAALKGK 254


                  ..
gi 119586555 1139 LS 1140
Cdd:COG4942   255 LP 256
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 844-1259 1.08e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 66.97  E-value: 1.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMN 923
Cdd:TIGR04523  222 ELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLN 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   924 ERLEDE--EEMNAELTAKKRKLE-----------------DECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAG 984
Cdd:TIGR04523  302 NQKEQDwnKELKSELKNQEKKLEeiqnqisqnnkiisqlnEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQS 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   985 LDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ--------------VDDLEGSLEQEKKVRMDLER 1050
Cdd:TIGR04523  382 YKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEierlketiiknnseIKDLTNQDSVKELIIKNLDN 461

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1051 AKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIedeqalgSQLQKKLKELQARIEELEEELEAERTARA 1130
Cdd:TIGR04523  462 TRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEK-------KELEEKVKDLTKKISSLKEKIEKLESEKK 534

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1131 KVEKLRSDLSRELEEISERLEEAGGATSVQ-----IEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD---SVAE 1202
Cdd:TIGR04523  535 EKESKISDLEDELNKDDFELKKENLEKEIDeknkeIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEkekKISS 614

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119586555  1203 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI------IKAKAANLEKMCRTLEDQMNE 1259
Cdd:TIGR04523  615 LEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIketikeIRNKWPEIIKKIKESKTKIDD 677
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 841-1152 1.23e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 67.02  E-value: 1.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920
Cdd:TIGR02169  696 ELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLH 775

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   921 EMNERLEDEEEMNA-----ELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Cdd:TIGR02169  776 KLEEALNDLEARLShsripEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKE 855

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   996 KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ 1075
Cdd:TIGR02169  856 IENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1076 LD--------------------ERLKKKDFELNAL---NARIEDEQAlgsQLQKKLKELQARIEELEEELEAERTARAKV 1132
Cdd:TIGR02169  936 IEdpkgedeeipeeelsledvqAELQRVEEEIRALepvNMLAIQEYE---EVLKRLDELKEKRAKLEEERKAILERIEEY 1012

                          330       340
                   ....*....|....*....|.
gi 119586555  1133 EKLRSDLSRE-LEEISERLEE 1152
Cdd:TIGR02169 1013 EKKKREVFMEaFEAINENFNE 1033
mukB PRK04863
chromosome partition protein MukB;
847-1696 1.64e-10

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 66.52  E-value: 1.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQliKNKIQ--------LEAK 918
Cdd:PRK04863  286 EEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNLVQTALRQ--QEKIEryqadleeLEER 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  919 VKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL-------------------------------ELTLAKVEKE 967
Cdd:PRK04863  364 LEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYqqaldvqqtraiqyqqavqalerakqlcglpDLTADNAEDW 443

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  968 KHATENKVKNLTEEMAGL-------DEIIAKLTKEKKALQ---------EAHQQALDDL-QAEEDKVntLTKAKVKLEQQ 1030
Cdd:PRK04863  444 LEEFQAKEQEATEELLSLeqklsvaQAAHSQFEQAYQLVRkiagevsrsEAWDVARELLrRLREQRH--LAEQLQQLRMR 521

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1031 VDDLEGSLEQEKkvrmDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKkkdfelnALNARIEDEQALGSQLQKKLKE 1110
Cdd:PRK04863  522 LSELEQRLRQQQ----RAERLLAEFCKRLGKNLDDEDELEQLQEELEARLE-------SLSESVSEARERRMALRQQLEQ 590

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1111 LQARIEELEEELEAERTARAKVEKLRSDLSRELEEiSERLEEAggatsvqiemnkkreaeFQKMRRDLEEATLQHEATAA 1190
Cdd:PRK04863  591 LQARIQRLAARAPAWLAAQDALARLREQSGEEFED-SQDVTEY-----------------MQQLLERERELTVERDELAA 652

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1191 ALRkkhadsvaELGEQIDNLQ--------RVKQKLEKEKSEFKLEL-DDVTSN------------MEQII----KAKAAN 1245
Cdd:PRK04863  653 RKQ--------ALDEEIERLSqpggsedpRLNALAERFGGVLLSEIyDDVSLEdapyfsalygpaRHAIVvpdlSDAAEQ 724

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1246 LEKMCRTLED---------QMNEHRSKAEETQRSVNDLTSQRAklqtengelSRqldekealISQLTR----GKLTYTQQ 1312
Cdd:PRK04863  725 LAGLEDCPEDlyliegdpdSFDDSVFSVEELEKAVVVKIADRQ---------WR--------YSRFPEvplfGRAAREKR 787

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1313 LEDLKRQLEEEVkaknalahalqsarhdcdllrEQYEEETEAKAELQRVLSKANSEVA-------QWRTKYETDAIQRT- 1384
Cdd:PRK04863  788 IEQLRAEREELA---------------------ERYATLSFDVQKLQRLHQAFSRFIGshlavafEADPEAELRQLNRRr 846

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1385 -------EELEEAKKKLAQRLQEAEEAVEAVN--AKCSSLEKTKHrLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI-- 1453
Cdd:PRK04863  847 veleralADHESQEQQQRSQLEQAKEGLSALNrlLPRLNLLADET-LADRVEEIREQLDEAEEAKRFVQQHGNALAQLep 925

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1454 -----------LAEWKQKYEESQSELESSQKEARSLsTELFKLKN--AYEESLEHLetfkrenknlqEEISDLTEQLgss 1520
Cdd:PRK04863  926 ivsvlqsdpeqFEQLKQDYQQAQQTQRDAKQQAFAL-TEVVQRRAhfSYEDAAEML-----------AKNSDLNEKL--- 990

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1521 gktiheleKVR-KQLEAEKMELQSALEEAEAslEHEEGKILRAQLE-----FNQIKAEIERKLAE----KDEEMEQAKRN 1590
Cdd:PRK04863  991 --------RQRlEQAEQERTRAREQLRQAQA--QLAQYNQVLASLKssydaKRQMLQELKQELQDlgvpADSGAEERARA 1060

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1591 HlrvVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV----KSLQSLLKdtqiqlddAVRAND 1666
Cdd:PRK04863 1061 R---RDELHARLSANRSRRNQLEKQLTFCEAEMDNLTKKLRKLERDYHEMREQVvnakAGWCAVLR--------LVKDNG 1129

                         970       980       990
                  ....*....|....*....|....*....|....*
gi 119586555 1667 dlkeniaiVERRnnLLQAEL-----EELRAVVEQT 1696
Cdd:PRK04863 1130 --------VERR--LHRRELaylsaDELRSMSDKA 1154
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1482-1910 1.77e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 66.24  E-value: 1.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1482 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAE------ASLEHE 1555
Cdd:PRK03918  167 LGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEelkeeiEELEKE 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1556 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNhLRVVDSLQTslDAETRSRNEALRVKKKMEgdLNEMEIQLSHANR 1635
Cdd:PRK03918  247 LESLEGSKRKLEEKIRELEERIEELKKEIEELEEK-VKELKELKE--KAEEYIKLSEFYEEYLDE--LREIEKRLSRLEE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1636 MAAEAQKQVKSLQSLLKDTQiqlddavrandDLKENIAIVERRNNLLQA---ELEELRAVVEQTERSRK-LAEQELIETS 1711
Cdd:PRK03918  322 EINGIEERIKELEEKEERLE-----------ELKKKLKELEKRLEELEErheLYEEAKAKKEELERLKKrLTGLTPEKLE 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1712 ERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAvqecRNAEEKAKKAITDAAMMAEELKKEqdtsaHLERMKKNMEQTI 1791
Cdd:PRK03918  391 KELEELEKAKEEIEEEISKITARIGELKKEIKEL----KKAIEELKKAKGKCPVCGRELTEE-----HRKELLEEYTAEL 461

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1792 KDLQHRLDEAEqialkggkKQLQKLEARVRELENELEAEQK--RNAESVKGMRKSERRIKELTYQT-EEDRKNLLRLQDL 1868
Cdd:PRK03918  462 KRIEKELKEIE--------EKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEElEKKAEEYEKLKEK 533

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 119586555 1869 VDKLQLKVKAYKRQAEEAEEQANtnlsKFRKVQHELDEAEER 1910
Cdd:PRK03918  534 LIKLKGEIKSLKKELEKLEELKK----KLAELEKKLDELEEE 571
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
841-1152 2.02e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.22  E-value: 2.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920
Cdd:PRK02224  357 RAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLR 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  921 EMNERLEDEEEMNAE-------LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLtEEMAGLDEIIAKLT 993
Cdd:PRK02224  437 TARERVEEAEALLEAgkcpecgQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERA-EDLVEAEDRIERLE 515

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  994 KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDL-EGSLEQEKKVRMDLERAKrKLEGDLKLTQESIMDLEND 1072
Cdd:PRK02224  516 ERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKrEAAAEAEEEAEEAREEVA-ELNSKLAELKERIESLERI 594

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1073 KQQLDERLKKKDfELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDlsRELEEISERLEE 1152
Cdd:PRK02224  595 RTLLAAIADAED-EIERLREKREALAELNDERRERLAEKRERKRELEAEFDEARIEEAREDKERAE--EYLEQVEEKLDE 671
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1104-1754 2.47e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 65.90  E-value: 2.47e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1104 LQKKLKELQARIEELEEELEAERTArakveklRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL---EE 1180
Cdd:pfam05483   97 IEAELKQKENKLQENRKIIEAQRKA-------IQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCarsAE 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1181 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE--FKLELD-DVTSNMEQIIKAKAANLEKMCRTLEDQM 1257
Cdd:pfam05483  170 KTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEmhFKLKEDhEKIQHLEEEYKKEINDKEKQVSLLLIQI 249

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1258 NEHRSKA-------EETQRSVNDLtSQRAKLQTENgelsrqldekealISQLTRGKLTYTQQLEDLKRQLEEEVKAKNAL 1330
Cdd:pfam05483  250 TEKENKMkdltfllEESRDKANQL-EEKTKLQDEN-------------LKELIEKKDHLTKELEDIKMSLQRSMSTQKAL 315

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1331 AHALQSA-RHDCDLLRE---QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQ----EAE 1402
Cdd:pfam05483  316 EEDLQIAtKTICQLTEEkeaQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQ-QRLEKNEDQLKIITMELQkkssELE 394

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1403 EAVEAVNAKCSSLEKTKHRLqNEIEDLMVDVERSNAAAAALDKKQRNF-------DKILAEWKQKYEESQSELESSQKEA 1475
Cdd:pfam05483  395 EMTKFKNNKEVELEELKKIL-AEDEKLLDEKKQFEKIAEELKGKEQELifllqarEKEIHDLEIQLTAIKTSEEHYLKEV 473

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1476 RSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI----HELEKVRKQ---LEAEKMELQSALEEA 1548
Cdd:pfam05483  474 EDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIinckKQEERMLKQienLEEKEMNLRDELESV 553

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1549 EASL--EHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG-DLNE 1625
Cdd:pfam05483  554 REEFiqKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENkQLNA 633

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1626 MEIQLSHANRMAAEAQKQ----VKSLQSLLKDTQIQ----LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE 1697
Cdd:pfam05483  634 YEIKVNKLELELASAKQKfeeiIDNYQKEIEDKKISeeklLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHK 713

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119586555  1698 RS------RKLAEQELIETSERVQ--LLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1754
Cdd:pfam05483  714 HQydkiieERDSELGLYKNKEQEQssAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKE 778
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 914-1344 2.63e-10

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 65.30  E-value: 2.63e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   914 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 993
Cdd:pfam07888   35 RLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELS 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   994 KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073
Cdd:pfam07888  115 EEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEF 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSreleeiserleEA 1153
Cdd:pfam07888  195 QELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELS-----------SM 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1154 GGATSvqiemnkKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKlelddvts 1233
Cdd:pfam07888  264 AAQRD-------RTQAELHQARLQAAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAELQ-------- 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1234 NMEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRsvnDLTSQRAKLQTENGELSRQLDEKEALisqltrgkLTYTQQL 1313
Cdd:pfam07888  329 RLEERLQEERMEREKLEVELGREKDCNRVQLSESRR---ELQELKASLRVAQKEKEQLQAEKQEL--------LEYIRQL 397

                          410       420       430
                   ....*....|....*....|....*....|.
gi 119586555  1314 EdlkRQLEEEVKAKNALAHALQSARHDCDLL 1344
Cdd:pfam07888  398 E---QRLETVADAKWSEAALTSTERPDSPLS 425
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1038-1448 3.31e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 65.17  E-value: 3.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1038 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQalgsqLQKKLKELQARIEE 1117
Cdd:COG4717    76 LEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEA-----LEAELAELPERLEE 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1118 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHA 1197
Cdd:COG4717   151 LEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1198 DSVAELgeqidNLQRVKQKLEKEKSEFKL---------ELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQ 1268
Cdd:COG4717   231 QLENEL-----EAAALEERLKEARLLLLIaaallallgLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAE 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1269 RSvnDLTSQRAKLQTEngELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALahALQSARHDCDLLREQY 1348
Cdd:COG4717   306 EL--QALPALEELEEE--ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL--QLEELEQEIAALLAEA 379

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1349 ----EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK-LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQ 1423
Cdd:COG4717   380 gvedEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEeLEEELEELEEELEELEEELEELREELAELE 459

                         410       420
                  ....*....|....*....|....*
gi 119586555 1424 NEIEDLMVDVERSNAAAAALDKKQR 1448
Cdd:COG4717   460 AELEQLEEDGELAELLQELEELKAE 484
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1478-1924 3.38e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 65.43  E-value: 3.38e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1478 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA---EASLEH 1554
Cdd:TIGR04523  122 LEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIknkLLKLEL 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1555 ---------EEGKILRAQL-----EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQ------TSLDAETRSRNEALR 1614
Cdd:TIGR04523  202 llsnlkkkiQKNKSLESQIselkkQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDeqnkikKQLSEKQKELEQNNK 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1615 VKKKMEGDLNEMEIQLSHANRMAA-----EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEEL 1689
Cdd:TIGR04523  282 KIKELEKQLNQLKSEISDLNNQKEqdwnkELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEK 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1690 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE 1769
Cdd:TIGR04523  362 QRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSE 441

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1770 LKKEQDTSAHLERMKKNMEQTIKDLQHRLD-------------EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAE 1836
Cdd:TIGR04523  442 IKDLTNQDSVKELIIKNLDNTRESLETQLKvlsrsinkikqnlEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISS 521

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1837 SVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQL-KVKAYKRQAEEAEEQANTNLSKfrkvqhELDEAEERADIAE 1915
Cdd:TIGR04523  522 LKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLeKEIDEKNKEIEELKQTQKSLKK------KQEEKQELIDQKE 595


                   ....*....
gi 119586555  1916 SQVNKLRAK 1924
Cdd:TIGR04523  596 KEKKDLIKE 604
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
967-1670 4.52e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 64.94  E-value: 4.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  967 EKHATENKVKNLTEEMAGLDEIiakltkeKKALQEAHQQaLDDLQAEEDKVNTLTKAKVKLEQQVDDLEgsleqekkvRM 1046
Cdd:COG4913   219 EEPDTFEAADALVEHFDDLERA-------HEALEDAREQ-IELLEPIRELAERYAAARERLAELEYLRA---------AL 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1047 DLERAKRKLEgdlkLTQESIMDLENDKQQLDERLKKKDFELNALNARIED-EQALGSQLQKKLKELQARIEELeeeleae 1125
Cdd:COG4913   282 RLWFAQRRLE----LLEAELEELRAELARLEAELERLEARLDALREELDElEAQIRGNGGDRLEQLEREIERL------- 350

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1126 RTARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnkkrEAEFQKMRRDLEEATlqheATAAALRKKHADSVAELGE 1205
Cdd:COG4913   351 ERELEERERRRARLEALLAALGLPLPAS--------------AEEFAALRAEAAALL----EALEEELEALEEALAEAEA 412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1206 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAANLEKMcrtlEDQMN------EHRSKAEETQRSVND-LTSQR 1278
Cdd:COG4913   413 ALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAEALGLD----EAELPfvgeliEVRPEEERWRGAIERvLGGFA 488

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1279 AKLqtengeLSRQLDEKEAL--ISQL-TRGKLTYtQQLEDLKRQLEEEVKAKNALAHALQSARHDC-DLLREQYEEET-- 1352
Cdd:COG4913   489 LTL------LVPPEHYAAALrwVNRLhLRGRLVY-ERVRTGLPDPERPRLDPDSLAGKLDFKPHPFrAWLEAELGRRFdy 561

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1353 ---EAKAELQRV--------LSKANSEVAQ------WRTKYET--DAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1413
Cdd:COG4913   562 vcvDSPEELRRHpraitragQVKGNGTRHEkddrrrIRSRYVLgfDNRAKLAALEAELAELEEELAEAEERLEALEAELD 641

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1414 SLEKTKHRLQN--EIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQkyeesqselessqkearsLSTELFKLKNAYEE 1491
Cdd:COG4913   642 ALQERREALQRlaEYSWDEIDVASAEREIAELEAELERLDASSDDLAA------------------LEEQLEELEAELEE 703

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1492 SLEHLETFKRENKNLQEEISDLTEqlgssgktihELEKVRKQLE-AEKMELQSALEEAEASLEHEEGKILRAQL--EFNQ 1568
Cdd:COG4913   704 LEEELDELKGEIGRLEKELEQAEE----------ELDELQDRLEaAEDLARLELRALLEERFAAALGDAVERELreNLEE 773

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1569 IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD------------LNEMEIQ-----LS 1631
Cdd:COG4913   774 RIDALRARLNRAEEELERAMRAFNREWPAETADLDADLESLPEYLALLDRLEEDglpeyeerfkelLNENSIEfvadlLS 853

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*
gi 119586555 1632 HANRMAAEAQKQVKSLQSLLK------DTQIQLDDAVRANDDLKE 1670
Cdd:COG4913   854 KLRRAIREIKERIDPLNDSLKripfgpGRYLRLEARPRPDPEVRE 898
PTZ00121 PTZ00121
MAEBL; Provisional
 1424-1928 4.76e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.16  E-value: 4.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1424 NEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSlSTELFKLKNAYE-ESLEHLETFKRE 1502
Cdd:PTZ00121 1082 DAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARK-AEDARKAEEARKaEDAKRVEIARKA 1160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1503 NKNLQEEISDLTEQlGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASleHEEGKILRAQLEFNQIKAEIERKLAEKDE 1582
Cdd:PTZ00121 1161 EDARKAEEARKAED-AKKAEAARKAEEVRKAEELRKAEDARKAEAARKA--EEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1583 EMEQAKR----NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDlnemEIQLSHANRMAAEAQK--QVKSLQSLLKDTQi 1656
Cdd:PTZ00121 1238 DAEEAKKaeeeRNNEEIRKFEEARMAHFARRQAAIKAEEARKAD----ELKKAEEKKKADEAKKaeEKKKADEAKKKAE- 1312

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1657 qlddAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSlinQKKKMDadls 1736
Cdd:PTZ00121 1313 ----EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEE---AKKKAD---- 1381

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1737 qlqtEVEEAVQECRNAEEKAKKAITDAAMmAEELKKEQDTSAHLERMKKNMEQTIKdlqhrLDEAEQialkggkkqlqKL 1816
Cdd:PTZ00121 1382 ----AAKKKAEEKKKADEAKKKAEEDKKK-ADELKKAAAAKKKADEAKKKAEEKKK-----ADEAKK-----------KA 1440

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1817 EARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKnllrlqdlVDKLQLKVKAYKRQAEEAE--EQANTNL 1894
Cdd:PTZ00121 1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKK--------ADEAKKKAEEAKKKADEAKkaAEAKKKA 1512

                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 119586555 1895 SKFRKVQH-----ELDEAEERADIAESQVNKLRAKSRDI 1928
Cdd:PTZ00121 1513 DEAKKAEEakkadEAKKAEEAKKADEAKKAEEKKKADEL 1551
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 839-1259 6.16e-10

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 64.46  E-value: 6.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   839 LLKSAEREKEMAS----------MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQL 908
Cdd:pfam10174  264 LLHTEDREEEIKQmevykshskfMKNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLTAKEQRAAIL 343

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   909 iknkiqlEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEI 988
Cdd:pfam10174  344 -------QTEVDALRLRLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQ 416

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   989 IAKLTKEKKALQEAHQQA------LDDLQAEEDKV-NTLTKAKVKLEQQVDDlegSLEQEKKVRMDLERAKRKLEGDLKL 1061
Cdd:pfam10174  417 LAGLKERVKSLQTDSSNTdtalttLEEALSEKERIiERLKEQREREDRERLE---ELESLKKENKDLKEKVSALQPELTE 493

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1062 TQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQarieeleeelEAERTARAKVEklRSDLSR 1141
Cdd:pfam10174  494 KESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKAH----------NAEEAVRTNPE--INDRIR 561

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1142 ELE-EISERLEEAGGA-TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA----------------ALRKKHADSVAEL 1203
Cdd:pfam10174  562 LLEqEVARYKEESGKAqAEVERLLGILREVENEKNDKDKKIAELESLTLRQmkeqnkkvanikhgqqEMKKKGAQLLEEA 641

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119586555  1204 GEQIDNLQRVKQKLEKEK-----SEFKLELDDVT---SNMEQIIKAKAANLEKMCRTLEDQMNE 1259
Cdd:pfam10174  642 RRREDNLADNSQQLQLEElmgalEKTRQELDATKarlSSTQQSLAEKDGHLTNLRAERRKQLEE 705
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 862-1568 8.50e-10

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 64.07  E-value: 8.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   862 ALEKSEARRKE-LEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK 940
Cdd:pfam10174   46 ALRKEEAARISvLKEQYRVTQEENQHLQLTIQALQDELRAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEH 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   941 RKLEDECSELKRDIDDLELtlaKVEKEKHATENKvknlteemaglDEIIAKLtkekkaLQEAHQQALDDLQAEEDkvNTL 1020
Cdd:pfam10174  126 ERQAKELFLLRKTLEEMEL---RIETQKQTLGAR-----------DESIKKL------LEMLQSKGLPKKSGEED--WER 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1021 TKAKVKLEQQVDDLEGSLEQEKKVRMDL-ERAKRKLEGDLKLTQESIMdlendkQQLDERLKKKDFELNALNARIEDE-Q 1098
Cdd:pfam10174  184 TRRIAEAEMQLGHLEVLLDQKEKENIHLrEELHRRNQLQPDPAKTKAL------QTVIEMKDTKISSLERNIRDLEDEvQ 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1099 ALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR---ELEEISERLEEAGGATS---VQIEMNKKREAEfq 1172
Cdd:pfam10174  258 MLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKIDQLKQELSKkesELLALQTKLETLTNQNSdckQHIEVLKESLTA-- 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1173 kmrRDLEEATLQHEATAAALRKKHADSVaeLGEQIDNLQRvkqkLEKEKSEFKLELDDVtSNMEQIIKAKAANLEKMCRT 1252
Cdd:pfam10174  336 ---KEQRAAILQTEVDALRLRLEEKESF--LNKKTKQLQD----LTEEKSTLAGEIRDL-KDMLDVKERKINVLQKKIEN 405

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1253 LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLtrgkltyTQQLEDLKRQLEEEVKaknALAH 1332
Cdd:pfam10174  406 LQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEALSEKERIIERL-------KEQREREDRERLEELE---SLKK 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1333 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK-----KLAQRLQEAEEAVEA 1407
Cdd:pfam10174  476 ENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKlenqlKKAHNAEEAVRTNPE 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1408 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELfKLKN 1487
Cdd:pfam10174  556 INDRIRLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEM-KKKG 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1488 AYEESLEHLETFKRENKNLQEEISDLTEqlgssgktihELEKVRKQLEAEKMEL---QSALEEAEA---SLEHEEGKILR 1561
Cdd:pfam10174  635 AQLLEEARRREDNLADNSQQLQLEELMG----------ALEKTRQELDATKARLsstQQSLAEKDGhltNLRAERRKQLE 704


                   ....*..
gi 119586555  1562 AQLEFNQ 1568
Cdd:pfam10174  705 EILEMKQ 711
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1616-1837 9.29e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 62.86  E-value: 9.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1616 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1695
Cdd:COG4942    22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1696 TER--SRKLAEQELIETSERVQLLHSQNTS--LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK 1771
Cdd:COG4942   102 QKEelAELLRALYRLGRQPPLALLLSPEDFldAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLA 181

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555 1772 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELENELEAEQKRNAES 1837
Cdd:COG4942   182 ELEEERAALEALKAERQKLLARLEKELAELAA-ELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1441-1881 1.11e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 63.63  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1441 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLtEQLGSS 1520
Cdd:COG4717    49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKL-EKLLQL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1521 GKTIHELEKVRKQLEAEKMELQsALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1600
Cdd:COG4717   128 LPLYQELEALEAELAELPERLE-ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQ 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1601 SLDAETRSRNEALRVKKKMEGDLNEMEIQLshanrMAAEAQKQVKSLQSLLK--DTQIQLDDAVRANDDLKENIA----- 1673
Cdd:COG4717   207 RLAELEEELEEAQEELEELEEELEQLENEL-----EAAALEERLKEARLLLLiaAALLALLGLGGSLLSLILTIAgvlfl 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1674 ------IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ 1747
Cdd:COG4717   282 vlgllaLLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEE 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1748 ECRNAEEKAKKA----------ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALkggKKQLQKLE 1817
Cdd:COG4717   362 ELQLEELEQEIAallaeagvedEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEEL---EEELEELE 438

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119586555 1818 ARVRELENELEAEQKRnaesvkgMRKSERRIKELTyQTEEDRKNLLRLQDLVDKLQLKVKAYKR 1881
Cdd:COG4717   439 EELEELEEELEELREE-------LAELEAELEQLE-EDGELAELLQELEELKAELRELAEEWAA 494
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1102-1338 2.54e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.32  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1102 SQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnkkrEAEFQKMRRDLEEA 1181
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAL--------------EQELAALEAELAEL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1182 TLQheatAAALRKKHADSVAELGEQIDNLQRVKQKlekEKSEFKLELDDV--TSNMEQIIKAKAANLEKMCRTLEDQMNE 1259
Cdd:COG4942    89 EKE----IAELRAELEAQKEELAELLRALYRLGRQ---PPLALLLSPEDFldAVRRLQYLKYLAPARREQAEELRADLAE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119586555 1260 HRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 1338
Cdd:COG4942   162 LAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAA 240
PTZ00121 PTZ00121
MAEBL; Provisional
 1488-1932 3.22e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.47  E-value: 3.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1488 AYEESLEHLETFKRENKNLQEEISDLTEQLGSSgktihelEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1567
Cdd:PTZ00121 1092 ATEEAFGKAEEAKKTETGKAEEARKAEEAKKKA-------EDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDAR 1164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1568 qiKAEIERKlAEKDEEMEQAKRnhlrvvdSLQTSLDAETRSRNEAlrvkKKMEGDLNEMEIQLSHANRMAAEAQK--QVK 1645
Cdd:PTZ00121 1165 --KAEEARK-AEDAKKAEAARK-------AEEVRKAEELRKAEDA----RKAEAARKAEEERKAEEARKAEDAKKaeAVK 1230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1646 SLQSLLKDTQiqldDAVRANddlKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNtsli 1725
Cdd:PTZ00121 1231 KAEEAKKDAE----EAKKAE---EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAE---- 1299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1726 nQKKKMDadlsqlqtEVEEAVQECRNAEEKAKKAiTDAAMMAEELKKEQdtsahlERMKKNMEQTIKDLQHRLDEAEQIA 1805
Cdd:PTZ00121 1300 -EKKKAD--------EAKKKAEEAKKADEAKKKA-EEAKKKADAAKKKA------EEAKKAAEAAKAEAEAAADEAEAAE 1363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1806 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQlKVKAYKRQAEE 1885
Cdd:PTZ00121 1364 EKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKK-KADEAKKKAEE 1442

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 119586555 1886 AE--EQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKR 1932
Cdd:PTZ00121 1443 AKkaDEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKK 1491
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
831-1145 7.87e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.85  E-value: 7.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  831 KLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIK 910
Cdd:PRK03918  477 KLRKELRELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKK 556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  911 NKIQLEAKVKEMNERLedeeemnAELTAKKRKLEDEC-SELKRDIDDLE------LTLAKVEKEKHATENKVKNLTEEma 983
Cdd:PRK03918  557 KLAELEKKLDELEEEL-------AELLKELEELGFESvEELEERLKELEpfyneyLELKDAEKELEREEKELKKLEEE-- 627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  984 gLDEIIAKLTKEKKALQEAHQQaLDDLQAEEDKvntltkakvkleqqvDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Cdd:PRK03918  628 -LDKAFEELAETEKRLEELRKE-LEELEKKYSE---------------EEYEELREEYLELSRELAGLRAELEELEKRRE 690

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1064 ESIMDLENDKQQLDERLKKKDfELNALNARIEDEQAlgsqLQKKLKELQARIeeleeeleaERTARAKVEKLRSDLSREL 1143
Cdd:PRK03918  691 EIKKTLEKLKEELEEREKAKK-ELEKLEKALERVEE----LREKVKKYKALL---------KERALSKVGEIASEIFEEL 756


                  ..
gi 119586555 1144 EE 1145
Cdd:PRK03918  757 TE 758
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 858-1327 8.51e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 60.89  E-value: 8.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   858 RLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERL----EDEEEMN 933
Cdd:pfam05483  216 KLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLkeliEKKDHLT 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   934 AELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 1013
Cdd:pfam05483  296 KELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKN 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1014 EDKVNTLTkakVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIM------DLENDKQQLDERLKKKDFEL 1087
Cdd:pfam05483  376 EDQLKIIT---MELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQfekiaeELKGKEQELIFLLQAREKEI 452

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1088 NALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEaggaTSVQIEMNKKR 1167
Cdd:pfam05483  453 HDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKK----HQEDIINCKKQ 528

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1168 EAEFQKMRRDLEEATLQheataaaLRkkhadsvaelgeqiDNLQRVKQKLEKEKSEFKLELDDVTSNMEQiIKAKAANLE 1247
Cdd:pfam05483  529 EERMLKQIENLEEKEMN-------LR--------------DELESVREEFIQKGDEVKCKLDKSEENARS-IEYEVLKKE 586

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1248 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAK 1327
Cdd:pfam05483  587 KQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDK 666
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 945-1152 1.07e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.39  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  945 DECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQeahqqalDDLQAEEDKVNTLTKAK 1024
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALE-------QELAALEAELAELEKEI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1025 VKLEQQVDDLEGSLEQEKKVrmdLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQL 1104
Cdd:COG4942    93 AELRAELEAQKEELAELLRA---LYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAEL 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 119586555 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE 1152
Cdd:COG4942   170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAE 217
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1205-1899 1.33e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 60.12  E-value: 1.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1205 EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ----------IIKAKAANL-------EKMCRTLEDQMNEHRSKAEEt 1267
Cdd:pfam05483   71 ENSEGLSRLYSKLYKEAEKIKKWKVSIEAELKQkenklqenrkIIEAQRKAIqelqfenEKVSLKLEEEIQENKDLIKE- 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1268 qrsvNDLTSQRAKLQTENGELSRQLDEKEALISQLTRgkltytQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL-LRE 1346
Cdd:pfam05483  150 ----NNATRHLCNLLKETCARSAEKTKKYEYEREETR------QVYMDLNNNIEKMILAFEELRVQAENARLEMHFkLKE 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1347 QYEEETEAKAELQRVLSKANSEVAQW---RTKYETDAIQRTEELEEAKKKLAQrlqeAEEAVEAVNAKCSSLEKTKHRLQ 1423
Cdd:pfam05483  220 DHEKIQHLEEEYKKEINDKEKQVSLLliqITEKENKMKDLTFLLEESRDKANQ----LEEKTKLQDENLKELIEKKDHLT 295

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1424 NEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKyEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1503
Cdd:pfam05483  296 KELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEE-KEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEK 374

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1504 KNLQEEIsdLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEasleheegKILRAQLEFNQIKAEierkLAEKDEE 1583
Cdd:pfam05483  375 NEDQLKI--ITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDE--------KLLDEKKQFEKIAEE----LKGKEQE 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1584 MEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ----LSHANRMAAEAQKQVKSLQSL---LKDTQI 1656
Cdd:pfam05483  441 LIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKnielTAHCDKLLLENKELTQEASDMtleLKKHQE 520

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1657 QLDDAVRANDDLKENIAIVERRNNLLQAELE-----------ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1725
Cdd:pfam05483  521 DIINCKKQEERMLKQIENLEEKEMNLRDELEsvreefiqkgdEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLK 600

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1726 NQKKKMDADLSQLQTEveeavqecrNAEEKAKKAITDAAMMAEELKKEQdTSAHLERMKKNMEQTIKDLQHRLdEAEQIA 1805
Cdd:pfam05483  601 KQIENKNKNIEELHQE---------NKALKKKGSAENKQLNAYEIKVNK-LELELASAKQKFEEIIDNYQKEI-EDKKIS 669

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1806 LKGGKKQLQKLEARVRE---LENELEAE-QKRNAESVKGMRKS--------ERRIKEL-TYQTEEDRKNLLR------LQ 1866
Cdd:pfam05483  670 EEKLLEEVEKAKAIADEavkLQKEIDKRcQHKIAEMVALMEKHkhqydkiiEERDSELgLYKNKEQEQSSAKaaleieLS 749

                          730       740       750
                   ....*....|....*....|....*....|....*...
gi 119586555  1867 DLVDKL-----QLKVKAYKRQAEEAEEQANTNLSKFRK 1899
Cdd:pfam05483  750 NIKAELlslkkQLEIEKEEKEKLKMEAKENTAILKDKK 787
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1226-1922 1.37e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 60.24  E-value: 1.37e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1226 LELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEhRSKAEETQRSVNDLTSQRAKLQTengeLSRQLDEKEALISQLTRG 1305
Cdd:pfam12128  206 LEDDGVVPPKSRLNRQQVEHWIRDIQAIAGIMKI-RPEFTKLQQEFNTLESAELRLSH----LHFGYKSDETLIASRQEE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1306 KLTYTQQLEDLKRQLEEEVKAK--------NALAHALQSARHDCDLLREQYEEETEAKAElqrVLSKANSEVAQWRTKye 1377
Cdd:pfam12128  281 RQETSAELNQLLRTLDDQWKEKrdelngelSAADAAVAKDRSELEALEDQHGAFLDADIE---TAAADQEQLPSWQSE-- 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1378 tdaiqrTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSlektkhRLQNEIEDLMVDVERSNAAAAALDKKQRN-FDKILAE 1456
Cdd:pfam12128  356 ------LENLEERLKALTGKHQDVTAKYNRRRSKIKE------QNNRDIAGIKDKLAKIREARDRQLAVAEDdLQALESE 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1457 WKQKYEESQSELESSQKEARSLSTELFKLKN---AYEESLEHLETFkrenknlQEEISDLTEQLGSSGKTIHELEKVRKQ 1533
Cdd:pfam12128  424 LREQLEAGKLEFNEEEYRLKSRLGELKLRLNqatATPELLLQLENF-------DERIERAREEQEAANAEVERLQSELRQ 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1534 LEAEKMELQSALEEAEASLEHEEGKILRAQ----------LEFNQIKAEIERKLAEKDEEMEQAKRNHLR-VVDSLQTS- 1601
Cdd:pfam12128  497 ARKRRDQASEALRQASRRLEERQSALDELElqlfpqagtlLHFLRKEAPDWEQSIGKVISPELLHRTDLDpEVWDGSVGg 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1602 --------LDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAnddLKENIA 1673
Cdd:pfam12128  577 elnlygvkLDLKRIDVPEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTA---LKNARL 653

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1674 IVERRNNLLQAELeelRAVVEQTERSRKLAEqelietsERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAE 1753
Cdd:pfam12128  654 DLRRLFDEKQSEK---DKKNKALAERKDSAN-------ERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVV 723

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1754 EKAKKAiTDAAMMAEELKKEQDTSAHLERMKKNMEqtiKDLQHRLDEAEQIAlkggkkqlqKLEARVRELENELEAEQKR 1833
Cdd:pfam12128  724 EGALDA-QLALLKAAIAARRSGAKAELKALETWYK---RDLASLGVDPDVIA---------KLKREIRTLERKIERIAVR 790

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1834 NAESVKGMRKSERRI----KELTYQTEEDRKNLLRLQDLVDKLQLKVKAyKRQAEEAEEQANtnlskfRKVQHELDEAEE 1909
Cdd:pfam12128  791 RQEVLRYFDWYQETWlqrrPRLATQLSNIERAISELQQQLARLIADTKL-RRAKLEMERKAS------EKQQVRLSENLR 863

                          730
                   ....*....|...
gi 119586555  1910 RADIAESQVNKLR 1922
Cdd:pfam12128  864 GLRCEMSKLATLK 876
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1593-1895 1.61e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 59.65  E-value: 1.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1593 RVVDSLQ--TSLDAETRSRNEAL-----RVKKKMEGDLNEMEIQLSHANrmAAEAQKQVKSLQSLLKDTQIQLddavran 1665
Cdd:COG3206    98 RVVDKLNldEDPLGEEASREAAIerlrkNLTVEPVKGSNVIEISYTSPD--PELAAAVANALAEAYLEQNLEL------- 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1666 ddlkeNIAIVERRNNLLQAELEELRAVVEQTERSRK--LAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVE 1743
Cdd:COG3206   169 -----RREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLA 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1744 eAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK----------KNMEQTIKDLQHRLDEAEQIALKGGKKQL 1813
Cdd:COG3206   244 -ALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSarytpnhpdvIALRAQIAALRAQLQQEAQRILASLEAEL 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1814 QKLEARVRELENELEAEQKRnaesVKGMRKSERRIKELTYQTEEDRKNllrLQDLVDKLQlkvkaykrQAEEAEEQANTN 1893
Cdd:COG3206   323 EALQAREASLQAQLAQLEAR----LAELPELEAELRRLEREVEVAREL---YESLLQRLE--------EARLAEALTVGN 387


                  ..
gi 119586555 1894 LS 1895
Cdd:COG3206   388 VR 389
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1045-1284 2.18e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 58.62  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1045 RMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIeeleeelea 1124
Cdd:COG4942    22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEI--------- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1125 ertarakvEKLRSDLSRELEEISERLEEA---GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRkkhadsva 1201
Cdd:COG4942    93 --------AELRAELEAQKEELAELLRALyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELR-------- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1202 elgEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAANlEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKL 1281
Cdd:COG4942   157 ---ADLAELAALRAELEAERAELEALLAELEEERAALEALKAER-QKLLARLEKELAELAAELAELQQEAEELEALIARL 232


                  ...
gi 119586555 1282 QTE 1284
Cdd:COG4942   233 EAE 235
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 861-1082 3.32e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 3.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  861 EALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK 940
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  941 RKLEDECSELKRDIddleltlakvekEKHATENKVKNLT-----EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED 1015
Cdd:COG4942   100 EAQKEELAELLRAL------------YRLGRQPPLALLLspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRmdlERAKRKLEGDLKLTQESIMDLENDKQQLDERLKK 1082
Cdd:COG4942   168 ELEAERAELEALLAELEEERAALEALKAER---QKLLARLEKELAELAAELAELQQEAEELEALIAR 231
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1648-1898 3.32e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 3.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1648 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQllhsqntSLINQ 1727
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELA-------ELEKE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1728 KKKMDADLSQLQTEVEEAVqecRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI--A 1805
Cdd:COG4942    92 IAELRAELEAQKEELAELL---RALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALraE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1806 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKgmrKSERRIKELTYQTEEDRKNLLRLQDLVDKLQlkvkayKRQAEE 1885
Cdd:COG4942   169 LEAERAELEALLAELEEERAALEALKAERQKLLA---RLEKELAELAAELAELQQEAEELEALIARLE------AEAAAA 239

                         250
                  ....*....|...
gi 119586555 1886 AEEQANTNLSKFR 1898
Cdd:COG4942   240 AERTPAAGFAALK 252
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1197-1414 3.41e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 3.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1197 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIiKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTS 1276
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAAL-ERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1277 QRAKLQTENGELSRQL------DEKEALIS-----QLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR 1345
Cdd:COG4942    98 ELEAQKEELAELLRALyrlgrqPPLALLLSpedflDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119586555 1346 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSS 1414
Cdd:COG4942   178 ALLAELEEERAALEALKAERQKLLARLEKELAELA-AELAELQQEAEELEALIARLEAEAAAAAERTPA 245
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1682-1929 3.90e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 58.65  E-value: 3.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1682 LQAELEELRAVVEQteRSRKLaEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEavQECRNAEEKAKKAIT 1761
Cdd:pfam01576   55 LCAEAEEMRARLAA--RKQEL-EEILHELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDE--EEAARQKLQLEKVTT 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1762 DAAM--MAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAlKGGKKQLQKLEARVRELENELEAEQKRNAESVK 1839
Cdd:pfam01576  130 EAKIkkLEEDILLLEDQNSKLSKERKLLEERISEFTSNLAEEEEKA-KSLSKLKNKHEAMISDLEERLKKEEKGRQELEK 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1840 GMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1919
Cdd:pfam01576  209 AKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARN 288

                          250
                   ....*....|
gi 119586555  1920 KLRAKSRDIG 1929
Cdd:pfam01576  289 KAEKQRRDLG 298
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 859-1875 3.98e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 58.91  E-value: 3.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   859 LKEALEKSEARRKeLEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIK--NKIQLEAKVKEMNerLEDEEEMNAEL 936
Cdd:TIGR01612  546 LKESYELAKNWKK-LIHEIKKELEEENEDSIHLEKEIKDLFDKYLEIDDEIIyiNKLKLELKEKIKN--ISDKNEYIKKA 622

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   937 TAKKRKLEDECSElkrdIDDleltLAKVEKEKhatenkvknLTEEMAGLDEIIAKLTKEkkaLQEAHQQALDDLQ----- 1011
Cdd:TIGR01612  623 IDLKKIIENNNAY----IDE----LAKISPYQ---------VPEHLKNKDKIYSTIKSE---LSKIYEDDIDALYnelss 682

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1012 --AEEDKVNTLTKAKvkleqqVDDLEGSLEQEKKVRMDLERAKRKLegdlkltqeSIMDLENDKQQLDE---RLKKKDF- 1085
Cdd:TIGR01612  683 ivKENAIDNTEDKAK------LDDLKSKIDKEYDKIQNMETATVEL---------HLSNIENKKNELLDiivEIKKHIHg 747

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1086 ELNA-LNARIEDeqalgsqLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164
Cdd:TIGR01612  748 EINKdLNKILED-------FKNKEKELSNKINDYAKEKDELNKYKSKISEIKNHYNDQINIDNIKDEDAKQNYDKSKEYI 820

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1165 KK---REAEFQKM---RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL-QRVKQKLEKEK-SEFKLELDDVTSNME 1236
Cdd:TIGR01612  821 KTisiKEDEIFKIineMKFMKDDFLNKVDKFINFENNCKEKIDSEHEQFAELtNKIKAEISDDKlNDYEKKFNDSKSLIN 900

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1237 QIIKA------------KAANLEKMCRTLEDQMNEHRSKaeetQRSVNDLTSQRAKLQTENGELSRQLDEK--EALISQL 1302
Cdd:TIGR01612  901 EINKSieeeyqnintlkKVDEYIKICENTKESIEKFHNK----QNILKEILNKNIDTIKESNLIEKSYKDKfdNTLIDKI 976

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1303 TRGKLTYTQ-QLEDLKRQLEEEVKAKNALAHALQSARHdcDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1381
Cdd:TIGR01612  977 NELDKAFKDaSLNDYEAKNNELIKYFNDLKANLGKNKE--NMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHTSIY 1054

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1382 QRTEELEEAKKKLAQRLQeaEEAVEAVNAKCSSLEKTKHRLQ----------------NEIEDLMVDVErsnaaaaALDK 1445
Cdd:TIGR01612 1055 NIIDEIEKEIGKNIELLN--KEILEEAEINITNFNEIKEKLKhynfddfgkeenikyaDEINKIKDDIK-------NLDQ 1125

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1446 KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN--AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKT 1523
Cdd:TIGR01612 1126 KIDHHIKALEEIKKKSENYIDEIKAQINDLEDVADKAISNDDpeEIEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIEKD 1205

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1524 IHELEKVR---------------KQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKlaekdEEMEQAK 1588
Cdd:TIGR01612 1206 KTSLEEVKginlsygknlgklflEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIK-----AEMETFN 1280

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1589 RNHLRVVDSLQTSLDAE---TRSRNEALRVKKKM--EGDLNEMEIQLshaNRMAAEAQKQVKSLQSLLKDTQ-----IQL 1658
Cdd:TIGR01612 1281 ISHDDDKDHHIISKKHDeniSDIREKSLKIIEDFseESDINDIKKEL---QKNLLDAQKHNSDINLYLNEIAniyniLKL 1357

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1659 DDAVRANDDLKENIAIVERRNNLLQAE----------------LEELRAVVEQTERSRKLAE--QELIETSERVQLLHSQ 1720
Cdd:TIGR01612 1358 NKIKKIIDEVKEYTKEIEENNKNIKDEldkseklikkikddinLEECKSKIESTLDDKDIDEciKKIKELKNHILSEESN 1437

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1721 NTSLINQKKKMDADLSQLQTEVEEAVQECRN-AEEKAKKAITDAAMMAEELKKEQDTS-----------AHLERMKKNME 1788
Cdd:TIGR01612 1438 IDTYFKNADENNENVLLLFKNIEMADNKSQHiLKIKKDNATNDHDFNINELKEHIDKSkgckdeadknaKAIEKNKELFE 1517

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1789 QTIKDLQHRLDEAEQIALKGG----KKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLR 1864
Cdd:TIGR01612 1518 QYKKDVTELLNKYSALAIKNKfaktKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAID 1597

                         1130
                   ....*....|.
gi 119586555  1865 LQDLVDKLQLK 1875
Cdd:TIGR01612 1598 IQLSLENFENK 1608
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1357-1931 4.33e-08

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 58.49  E-value: 4.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1357 ELQRVLSKANSEVA---QWRTKYETDAIQRTEELEEAKKKLAQRLQE---AEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1430
Cdd:TIGR04523  100 KLNSDLSKINSEIKndkEQKNKLEVELNKLEKQKKENKKNIDKFLTEikkKEKELEKLNNKYNDLKKQKEELENELNLLE 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1431 VDversnaaaaaLDKKQRNFDKILAEWKQKYEESQSELESSQKEaRSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1510
Cdd:TIGR04523  180 KE----------KLNIQKNIDKIKNKLLKLELLLSNLKKKIQKN-KSLESQISELKKQNNQLKDNIEKKQQEINEKTTEI 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1511 SDLTEQLGSsgkTIHELEKVRKQLEAEKMELQSAleeaeasleheEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN 1590
Cdd:TIGR04523  249 SNTQTQLNQ---LKDEQNKIKKQLSEKQKELEQN-----------NKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKS 314

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1591 HLRVVDS----LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1666
Cdd:TIGR04523  315 ELKNQEKkleeIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQIN 394

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1667 DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAV 1746
Cdd:TIGR04523  395 DLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLS 474

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1747 QECRNAEEKAKKaitdaamMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE--AEQIALKGGKKQLQK--------- 1815
Cdd:TIGR04523  475 RSINKIKQNLEQ-------KQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSlkEKIEKLESEKKEKESkisdledel 547

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1816 -----------LEARVRELENELEaEQKRNAESVKgmrKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVkayKRQAE 1884
Cdd:TIGR04523  548 nkddfelkkenLEKEIDEKNKEIE-ELKQTQKSLK---KKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSL---EKELE 620

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*..
gi 119586555  1885 EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1931
Cdd:TIGR04523  621 KAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKK 667
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1205-1442 4.88e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.47  E-value: 4.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1205 EQIDNLQRVKQKLEKEKSEFKLELDDvtsnmeqiIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1284
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAA--------LKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1285 NGELSRQLDEKEALISQLTRgkltyTQQLEDLKRQLEEEVKAKNA--LAHALQSARHDCDLLREQYEEETEAKAELQRVL 1362
Cdd:COG4942    92 IAELRAELEAQKEELAELLR-----ALYRLGRQPPLALLLSPEDFldAVRRLQYLKYLAPARREQAEELRADLAELAALR 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1363 SKANSEVAQWRTKYETDAIQRtEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1442
Cdd:COG4942   167 AELEAERAELEALLAELEEER-AALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 969-1199 5.38e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.08  E-value: 5.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  969 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQekkvrmdL 1048
Cdd:COG4942    16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAE-------L 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1049 ERAKRKLEGDLKLTQESIMDLENDKQQLDER------LKKKDFE-----LNALNARIEDEQALGSQLQKKLKELQARIEE 1117
Cdd:COG4942    89 EKEIAELRAELEAQKEELAELLRALYRLGRQpplallLSPEDFLdavrrLQYLKYLAPARREQAEELRADLAELAALRAE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1118 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAggatSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHA 1197
Cdd:COG4942   169 LEAERAELEALLAELEEERAALEALKAERQKLLARL----EKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244


                  ..
gi 119586555 1198 DS 1199
Cdd:COG4942   245 AA 246
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1010-1223 5.62e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.08  E-value: 5.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1090 LNARIEDEQALGSQLQKKL--KELQARIEELEEELEAERTARA-----KVEKLRSDLSRELEEISERLEEAGGATSVQIE 1162
Cdd:COG4942    95 LRAELEAQKEELAELLRALyrLGRQPPLALLLSPEDFLDAVRRlqylkYLAPARREQAEELRADLAELAALRAELEAERA 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119586555 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKK---HADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKElaeLAAELAELQQEAEELEALIARLEAEAAA 238
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1185-1927 6.36e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 57.93  E-value: 6.36e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKlELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKA 1264
Cdd:pfam12128  228 RDIQAIAGIMKIRPEFTKLQQEFNTLESAELRLSHLHFGYK-SDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDEL 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1265 EetqrsvNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQsarhdcDLL 1344
Cdd:pfam12128  307 N------GELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQ------DVT 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1345 REQYEEETEAKAELQRVLSKANSEVAQwrtKYETDAIQRTEElEEAKKKLAQRLQEAEEAVEAvnakcsSLEKTKHRLQN 1424
Cdd:pfam12128  375 AKYNRRRSKIKEQNNRDIAGIKDKLAK---IREARDRQLAVA-EDDLQALESELREQLEAGKL------EFNEEEYRLKS 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1425 EIEDLMVdveRSNAAAAALDKK--QRNFDKILAEWKQKyeesqseLESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1502
Cdd:pfam12128  445 RLGELKL---RLNQATATPELLlqLENFDERIERAREE-------QEAANAEVERLQSELRQARKRRDQASEALRQASRR 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1503 NKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE---KMELQSALEEAEASLEHEEGKIlRAQLEFNQIKAEIERKLAE 1579
Cdd:pfam12128  515 LEERQSALDELELQLFPQAGTLLHFLRKEAPDWEQsigKVISPELLHRTDLDPEVWDGSV-GGELNLYGVKLDLKRIDVP 593

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1580 KDEEMEQAKRNHLrvvDSLQTSLDAEtRSRNEALrvkkkmegdlnemEIQLSHANRMAAEAQKQVKSLQSLLK---DTQI 1656
Cdd:pfam12128  594 EWAASEEELRERL---DKAEEALQSA-REKQAAA-------------EEQLVQANGELEKASREETFARTALKnarLDLR 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1657 QLDDAVRANDDLKENiaIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETServqllhSQNTSLINQKKK-----M 1731
Cdd:pfam12128  657 RLFDEKQSEKDKKNK--ALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQK-------REARTEKQAYWQvvegaL 727

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1732 DADLSQLQTEVeEAVQECRNAEEKAKKaitdaAMMAEELKK---EQDTSAHLERMKKNMEQTIKDLQHRLDEA---EQIA 1805
Cdd:pfam12128  728 DAQLALLKAAI-AARRSGAKAELKALE-----TWYKRDLASlgvDPDVIAKLKREIRTLERKIERIAVRRQEVlryFDWY 801

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1806 LKGGKKQLQKLEARVRELEN---ELEAEQKRNAESVKgmrkseRRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQ 1882
Cdd:pfam12128  802 QETWLQRRPRLATQLSNIERaisELQQQLARLIADTK------LRRAKLEMERKASEKQQVRLSENLRGLRCEMSKLATL 875

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*.
gi 119586555  1883 AEEAE-EQANTNLSkfrkvqHELDEAEERADIAESQVNKLRAKSRD 1927
Cdd:pfam12128  876 KEDANsEQAQGSIG------ERLAQLEDLKLKRDYLSESVKKYVEH 915
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 851-1033 7.71e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 55.32  E-value: 7.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  851 SMKEEFTRLKEaLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLE-DE 929
Cdd:COG1579     1 AMPEDLRALLD-LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKkYE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  930 EEMNAELTAKKRK-LEDECSELKRDIDDLEltlakvEKEKHATEnKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008
Cdd:COG1579    80 EQLGNVRNNKEYEaLQKEIESLKRRISDLE------DEILELME-RIEELEEELAELEAELAELEAELEEKKAELDEELA 152

                         170       180
                  ....*....|....*....|....*
gi 119586555 1009 DLQAEEDKvntLTKAKVKLEQQVDD 1033
Cdd:COG1579   153 ELEAELEE---LEAEREELAAKIPP 174
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1241-1456 7.98e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.70  E-value: 7.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1241 AKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQL 1320
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1321 EEEVKA-KNALAHALQSARHDCDLLREQYEEETEAKAELQRVlskanSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1399
Cdd:COG4942   100 EAQKEElAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYL-----KYLAPARREQAEELRADLAELAALRAELEAERA 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555 1400 EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAE 1456
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
PRK01156 PRK01156
chromosome segregation protein; Provisional
 833-1409 8.32e-08

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 57.60  E-value: 8.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  833 YFKIKPLLKSAERE-KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA---EQDNLADAEERCDQL 908
Cdd:PRK01156  168 YDKLKDVIDMLRAEiSNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNamdDYNNLKSALNELSSL 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  909 IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLedecselkrdiddLELTLAKVEKEKHATeNKVKNLTEEMAGLDEI 988
Cdd:PRK01156  248 EDMKNRYESEIKTAESDLSMELEKNNYYKELEERH-------------MKIINDPVYKNRNYI-NDYFKYKNDIENKKQI 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  989 IAKLTKEKKALQEAHQQaLDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSleqekkvRMDLERAKRKLEGDLKLTQESIMD 1068
Cdd:PRK01156  314 LSNIDAEINKYHAIIKK-LSVLQKDYNDYIKKKSRYDDLNNQILELEGY-------EMDYNSYLKSIESLKKKIEEYSKN 385

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1069 LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA------------------ 1130
Cdd:PRK01156  386 IERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEmlngqsvcpvcgttlgee 465

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1131 KVEKLRSDLSRELEEISE---RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI 1207
Cdd:PRK01156  466 KSNHIINHYNEKKSRLEEkirEIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKH 545

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1208 DnlqrvkqKLEKEKSEFK-LELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENG 1286
Cdd:PRK01156  546 D-------KYEEIKNRYKsLKLEDLDSKRTSWLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYID 618

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1287 ELSRQLDEKealiSQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1366
Cdd:PRK01156  619 KSIREIENE----ANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAK 694

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 119586555 1367 SEVAQWRTKYETDaIQRTEELEEAKKKLAQRLQEAEEAVEAVN 1409
Cdd:PRK01156  695 ANRARLESTIEIL-RTRINELSDRINDINETLESMKKIKKAIG 736
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 833-1284 1.09e-07

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 56.77  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  833 YFKIKPLLKSAER-----EKEMASMKEEFTRLKEALEKSEARRKELEEKMvsllqekNDLQLQVQAEQDNLADAEErcdq 907
Cdd:PRK04778  100 FRKAKHEINEIESlldliEEDIEQILEELQELLESEEKNREEVEQLKDLY-------RELRKSLLANRFSFGPALD---- 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  908 liknkiQLEAKVKEMNERLEDEEEMNAE---LTAKK--RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKN----L 978
Cdd:PRK04778  169 ------ELEKQLENLEEEFSQFVELTESgdyVEAREilDQLEEELAALEQIMEEIPELLKELQTELPDQLQELKAgyreL 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  979 TEEMAGLDEIiaKLTKEKKALQEAHQQALDDLQAEEdkvntLTKAKVKLEQ---QVDDLEGSLEQEKKVRMDLERAKRKL 1055
Cdd:PRK04778  243 VEEGYHLDHL--DIEKEIQDLKEQIDENLALLEELD-----LDEAEEKNEEiqeRIDQLYDILEREVKARKYVEKNSDTL 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1056 EGDLKLTQESIMDLENDKQQLDERlkkkdFELNalnariEDEQALGSQLQKKLKELQARIEELEEELeaertarAKVEKL 1135
Cdd:PRK04778  316 PDFLEHAKEQNKELKEEIDRVKQS-----YTLN------ESELESVRQLEKQLESLEKQYDEITERI-------AEQEIA 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1136 RSDLSRELEEISERLEEAggatsvqiemnKKREAEFQKMRRDLEEATLQHEATAAALRKKhadsvaelgeqidnLQRVKQ 1215
Cdd:PRK04778  378 YSELQEELEEILKQLEEI-----------EKEQEKLSEMLQGLRKDELEAREKLERYRNK--------------LHEIKR 432

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119586555 1216 KLEKEK-----SEFKLELDDVTSNMEQiikakaanlekmcrtLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1284
Cdd:PRK04778  433 YLEKSNlpglpEDYLEMFFEVSDEIEA---------------LAEELEEKPINMEAVNRLLEEATEDVETLEEE 491
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1318-1776 1.24e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.70  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1318 RQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWrtkyetDAIQRTEELEEAKKKLAQR 1397
Cdd:COG4717    74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL------PLYQELEALEAELAELPER 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1398 LQEAEEAVEAVN---AKCSSLEKTKHRLQNEIEDLMVDVerSNAAAAALDKKQRNFDKILAEWKQkyeesqselesSQKE 1474
Cdd:COG4717   148 LEELEERLEELReleEELEELEAELAELQEELEELLEQL--SLATEEELQDLAEELEELQQRLAE-----------LEEE 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1475 ARSLSTELfklkNAYEESLEHLETfKRENKNLQEEISDLTEQLGSSGkTIHELEKVRKQLEAEKMELQSALEEAEASLEH 1554
Cdd:COG4717   215 LEEAQEEL----EELEEELEQLEN-ELEAAALEERLKEARLLLLIAA-ALLALLGLGGSLLSLILTIAGVLFLVLGLLAL 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1555 EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQakrnhlrvVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1634
Cdd:COG4717   289 LFLLLAREKASLGKEAEELQALPALEELEEEE--------LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELE 360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1635 RmAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA---------EQ 1705
Cdd:COG4717   361 E-ELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEeleeeleelEE 439

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119586555 1706 ELIETSERVQLLHSQNTSLINQKKKM--DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1776
Cdd:COG4717   440 ELEELEEELEELREELAELEAELEQLeeDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREE 512
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 839-1056 1.27e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.93  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  839 LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAK 918
Cdd:COG4942    12 ALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  919 VKEMNERLEDEEEMNAELTAKKRKLEDEcSELK-----RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 993
Cdd:COG4942    92 IAELRAELEAQKEELAELLRALYRLGRQ-PPLAlllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119586555  994 KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1056
Cdd:COG4942   171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLE 233
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
929-1360 1.39e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.70  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  929 EEEMNAELTAKKRKLEDECSELKRDIDDLElTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALqEAHQQALD 1008
Cdd:COG4717    52 EKEADELFKPQGRKPELNLKELKELEEELK-EAEEKEEEYAELQEELEELEEELEELEAELEELREELEKL-EKLLQLLP 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1009 DLQAEEDKVNTLTKAKVKLEQqvddlegsLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK-QQLDERLKKKDFEL 1087
Cdd:COG4717   130 LYQELEALEAELAELPERLEE--------LEERLEELRELEEELEELEAELAELQEELEELLEQLsLATEEELQDLAEEL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1088 NALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRS--------DLSRELEEISERLEEAGGATSV 1159
Cdd:COG4717   202 EELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLlliaaallALLGLGGSLLSLILTIAGVLFL 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1160 QIEM----------------NKKREAEFQKMRRDLEEATLQHEATAAAL-RKKHADSVAELGEQIDNLQRVKQKLEKEKS 1222
Cdd:COG4717   282 VLGLlallflllarekaslgKEAEELQALPALEELEEEELEELLAALGLpPDLSPEELLELLDRIEELQELLREAEELEE 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1223 EFKLelddvtsnmEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLD--EKEALIS 1300
Cdd:COG4717   362 ELQL---------EELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEalDEEELEE 432

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1301 QLTRgkltYTQQLEDLKRQLEEEVKAKNALAHALQSARHDcDLLREQYEEETEAKAELQR 1360
Cdd:COG4717   433 ELEE----LEEELEELEEELEELREELAELEAELEQLEED-GELAELLQELEELKAELRE 487
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1482-1928 1.46e-07

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 56.40  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1482 LFKLKNAYEEsLEHLETFKRE--NKNLQEEISDLtEQLGSSGKTIHELEKVRKQ---LEAEKM-ELQSALEEAEASLEhe 1555
Cdd:pfam06160    2 LLLRKKIYKE-IDELEERKNElmNLPVQEELSKV-KKLNLTGETQEKFEEWRKKwddIVTKSLpDIEELLFEAEELND-- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1556 EGKILRAQLEFNqikaEIERKLAEKDEEMEQakrnhlrVVDSLQTSLDAETRSRNEALRVKKK----------------- 1618
Cdd:pfam06160   78 KYRFKKAKKALD----EIEELLDDIEEDIKQ-------ILEELDELLESEEKNREEVEELKDKyrelrktllanrfsygp 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1619 ----MEGDLNEMEIQLSHA-NRMAA----EAQKQVKSLQSLLKDTQIQLDDavranddlkenI-AIVERRNNLLQAELEE 1688
Cdd:pfam06160  147 aideLEKQLAEIEEEFSQFeELTESgdylEAREVLEKLEEETDALEELMED-----------IpPLYEELKTELPDQLEE 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1689 LRAVVEQTERSR-KLAEQELIETSERVQLLHSQNTSLINQK--KKMDADLSQLQTEVEEaVQECRNAEEKAKKaitdaam 1765
Cdd:pfam06160  216 LKEGYREMEEEGyALEHLNVDKEIQQLEEQLEENLALLENLelDEAEEALEEIEERIDQ-LYDLLEKEVDAKK------- 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1766 maeELKKEQDT-SAHLERMKKNMEQTIKDLQH-----RLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVK 1839
Cdd:pfam06160  288 ---YVEKNLPEiEDYLEHAEEQNKELKEELERvqqsyTLNENELERVRGLEKQLEELEKRYDEIVERLEEKEVAYSELQE 364

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1840 GMRKSERRIKELTYQTEEDRKNL-------LRLQDLVDKLQLKVKAYKRQAE----------------EAEEQANTNLSK 1896
Cdd:pfam06160  365 ELEEILEQLEEIEEEQEEFKESLqslrkdeLEAREKLDEFKLELREIKRLVEksnlpglpesyldyffDVSDEIEDLADE 444

                          490       500       510
                   ....*....|....*....|....*....|..
gi 119586555  1897 FRKVQHELDEAEERADIAESQVNKLRAKSRDI 1928
Cdd:pfam06160  445 LNEVPLNMDEVNRLLDEAQDDVDTLYEKTEEL 476
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 845-1836 1.60e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 56.98  E-value: 1.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   845 REKEMASMKEEFTRLKEALEKSEARRKELeekmvsllqeKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNE 924
Cdd:TIGR01612  763 KEKELSNKINDYAKEKDELNKYKSKISEI----------KNHYNDQINIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFK 832

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   925 RLEDEEEMNAELTAKKRK---LEDECSElkrDIDDLELTLAKVEkekhateNKVKNLTEEmAGLDEIIAKLTKEKKALQE 1001
Cdd:TIGR01612  833 IINEMKFMKDDFLNKVDKfinFENNCKE---KIDSEHEQFAELT-------NKIKAEISD-DKLNDYEKKFNDSKSLINE 901

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1002 AHQQalddLQAEEDKVNTLTKakvkLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLK 1081
Cdd:TIGR01612  902 INKS----IEEEYQNINTLKK----VDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNLIEKSYKDKFDNTLI 973

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1082 KKDFELNAL--NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAkvEKLRSDLSRELEE-------------- 1145
Cdd:TIGR01612  974 DKINELDKAfkDASLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDEK--EKATNDIEQKIEDanknipnieiaiht 1051

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1146 ----ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1221
Cdd:TIGR01612 1052 siynIIDEIEKEIGKNIELLNKEILEEAEINITNFNEIKEKLKHYNFDDFGKEENIKYADEINKIKDDIKNLDQKIDHHI 1131

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1222 SEFKlELDDVTSNMEQIIKAKAANLEKMCRTLedQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ 1301
Cdd:TIGR01612 1132 KALE-EIKKKSENYIDEIKAQINDLEDVADKA--ISNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIEKDKTS 1208

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1302 LTRGK---LTYTQQLEDL-KRQLEEEVKAKNALAHALQSARHDCDLLREQYEE-------ETEAKAELQrVLSKANSEva 1370
Cdd:TIGR01612 1209 LEEVKginLSYGKNLGKLfLEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEienemgiEMDIKAEME-TFNISHDD-- 1285

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1371 qwRTKYETDAIQRTEELEEAKKKLAQRLQEaeeaveavNAKCSSLEKTKHRLQNEIedlmVDVERSNAAAAALDKKQRNF 1450
Cdd:TIGR01612 1286 --DKDHHIISKKHDENISDIREKSLKIIED--------FSEESDINDIKKELQKNL----LDAQKHNSDINLYLNEIANI 1351

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1451 DKILaewkqkyeesqselessqkearslstELFKLKNAYEESLEHLETFKRENKNLQEEISDlTEQLGssgKTIHElekv 1530
Cdd:TIGR01612 1352 YNIL--------------------------KLNKIKKIIDEVKEYTKEIEENNKNIKDELDK-SEKLI---KKIKD---- 1397

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1531 RKQLEAEKMELQSALEEAEAsleheEGKILRAQLEFNQIKAEierkLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRN 1610
Cdd:TIGR01612 1398 DINLEECKSKIESTLDDKDI-----DECIKKIKELKNHILSE----ESNIDTYFKNADENNENVLLLFKNIEMADNKSQH 1468

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1611 eALRVKKK-----MEGDLNEMEIQLSHANRMAAEAQKQVKSLQS---LLKdtQIQLDDAVRAND----DLKENIAIVERR 1678
Cdd:TIGR01612 1469 -ILKIKKDnatndHDFNINELKEHIDKSKGCKDEADKNAKAIEKnkeLFE--QYKKDVTELLNKysalAIKNKFAKTKKD 1545

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1679 NNLLQAELEELRAVV----EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ--TEVEEAVQECRNA 1752
Cdd:TIGR01612 1546 SEIIIKEIKDAHKKFileaEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLENFENKFLkiSDIKKKINDCLKE 1625

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1753 EEKAKKAITDAAMMAEE--LKKEQDTSAHLERMKKNMEQTIKDLQHRldeaeqialkggKKQLQKLEARVRELENELEaE 1830
Cdd:TIGR01612 1626 TESIEKKISSFSIDSQDteLKENGDNLNSLQEFLESLKDQKKNIEDK------------KKELDELDSEIEKIEIDVD-Q 1692


                   ....*.
gi 119586555  1831 QKRNAE 1836
Cdd:TIGR01612 1693 HKKNYE 1698
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
 651-675 2.04e-07

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 52.73  E-value: 2.04e-07
                          10        20
                  ....*....|....*....|....*
gi 119586555  651 HRENLNKLMTNLRSTHPHFVRCIIP 675
Cdd:cd01363   146 INESLNTLMNVLRATRPHFVRCISP 170
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 853-1429 2.07e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 56.50  E-value: 2.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  853 KEEFTRLKEALEK--SEARRKELEEKMVSLLQEKNDLQLQVQAEQD---NLADAEERCDQLIKNKIQLEAKVKEMNERLE 927
Cdd:COG3096   471 RRQFEKAYELVCKiaGEVERSQAWQTARELLRRYRSQQALAQRLQQlraQLAELEQRLRQQQNAERLLEEFCQRIGQQLD 550

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  928 DEEEmnaeltakkrkLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL----------DEIIAKLTKE-- 995
Cdd:COG3096   551 AAEE-----------LEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELaarapawlaaQDALERLREQsg 619

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  996 -----KKALQEAHQQALDD---LQAEEDKvntLTKAKVKLEQQV------------------------------DD---- 1033
Cdd:COG3096   620 ealadSQEVTAAMQQLLERereATVERDE---LAARKQALESQIerlsqpggaedprllalaerlggvllseiyDDvtle 696

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1034 -------LEGSLEQEKKVRmDLERAKRKLEGdLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQK 1106
Cdd:COG3096   697 dapyfsaLYGPARHAIVVP-DLSAVKEQLAG-LEDCPEDLYLIEGDPDSFDDSVFDAEELEDAVVVKLSDRQWRYSRFPE 774

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1107 klkelqarieeleeeleAERTARAKVEKLRSDLSRELEEISERLEEAggATSVQiemnkkreaEFQKMRRDLEEATLQH- 1185
Cdd:COG3096   775 -----------------VPLFGRAAREKRLEELRAERDELAEQYAKA--SFDVQ---------KLQRLHQAFSQFVGGHl 826

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1186 --------EATAAALRKKHADSVAELGEQIDNLQRVKQKLEkeksEFKLELDDVTSNMEQIIKAKAANLEKMCRTLEdqm 1257
Cdd:COG3096   827 avafapdpEAELAALRQRRSELERELAQHRAQEQQLRQQLD----QLKEQLQLLNKLLPQANLLADETLADRLEELR--- 899

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1258 nEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKltytQQLEDLKRQ---LEEEVKAKNALAH-- 1332
Cdd:COG3096   900 -EELDAAQEAQAFIQQHGKALAQLEPLVAVLQSDPEQFEQLQADYLQAK----EQQRRLKQQifaLSEVVQRRPHFSYed 974

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1333 ALQSARHDCDL---LREQYEEETEAKAELQRVLSKANSEVAQW-----------RTKYET--DAIQRTEELE-----EAK 1391
Cdd:COG3096   975 AVGLLGENSDLnekLRARLEQAEEARREAREQLRQAQAQYSQYnqvlaslkssrDAKQQTlqELEQELEELGvqadaEAE 1054

                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 119586555 1392 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1429
Cdd:COG3096  1055 ERARIRRDELHEELSQNRSRRSQLEKQLTRCEAEMDSL 1092
PRK01156 PRK01156
chromosome segregation protein; Provisional
 854-1231 2.26e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 56.06  E-value: 2.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  854 EEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIK----NKIQLEAKVKEMNERLEDE 929
Cdd:PRK01156  342 IKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKiqeiDPDAIKKELNEINVKLQDI 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  930 EEMNAELTAKKRKLEDECSELKRD-------------------------IDDLELTLAKVEKEKHATENKVKNLTEEMAG 984
Cdd:PRK01156  422 SSKVSSLNQRIRALRENLDELSRNmemlngqsvcpvcgttlgeeksnhiINHYNEKKSRLEEKIREIEIEVKDIDEKIVD 501

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  985 LDEIIAKLTKEKKALQEAHQQALDDLQAE----EDKVNTLTKAKVKLEQ--------QVDDLEGSLEQEKK--------- 1043
Cdd:PRK01156  502 LKKRKEYLESEEINKSINEYNKIESARADlediKIKINELKDKHDKYEEiknrykslKLEDLDSKRTSWLNalavislid 581

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1044 ---VRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR---IEDEQALGSQLQKKLKELQARIEE 1117
Cdd:PRK01156  582 ietNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKyneIQENKILIEKLRGKIDNYKKQIAE 661

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1118 LEEELEAERTARAKVEKLRSDL---SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194
Cdd:PRK01156  662 IDSIIPDLKEITSRINDIEDNLkksRKALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKKIKKAIGDLKRL 741

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 119586555 1195 KHADSVAELGEQI--DNLQRVKQKLEKEKSEFKLELDDV 1231
Cdd:PRK01156  742 REAFDKSGVPAMIrkSASQAMTSLTRKYLFEFNLDFDDI 780
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1139-1792 2.27e-07

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 55.98  E-value: 2.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1139 LSRELEEISERLEEaggaTSVQIEMNKKR-EAEFQKMRRDLEeaTLQHEATAAALRKKHADSVAELGE---QIDNLQRVK 1214
Cdd:pfam10174  128 QAKELFLLRKTLEE----MELRIETQKQTlGARDESIKKLLE--MLQSKGLPKKSGEEDWERTRRIAEaemQLGHLEVLL 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1215 QKLEKEKSEFKLEL---------DDVTSNMEQIIKAK---AANLEKMCRTLEDQMNEHRSKA-------EETQRSVNDLT 1275
Cdd:pfam10174  202 DQKEKENIHLREELhrrnqlqpdPAKTKALQTVIEMKdtkISSLERNIRDLEDEVQMLKTNGllhtedrEEEIKQMEVYK 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1276 SQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE---EEVKAKNALAHALQSarhDCDLLREQYEEEt 1352
Cdd:pfam10174  282 SHSKFMKNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQHIEvlkESLTAKEQRAAILQT---EVDALRLRLEEK- 357

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1353 eakaelQRVLSKansevaqwrtkyETDAIQRteeLEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD 1432
Cdd:pfam10174  358 ------ESFLNK------------KTKQLQD---LTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQ 416

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1433 VERSNAAAAALDKKQRNFDKILAEWKQKyEESQSELESSQKEARSLSTElfklknayeESLEHLETFKRENKNLQEEISD 1512
Cdd:pfam10174  417 LAGLKERVKSLQTDSSNTDTALTTLEEA-LSEKERIIERLKEQREREDR---------ERLEELESLKKENKDLKEKVSA 486

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1513 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEH--EEGKILRAQLEFNQIKAEIERK---LAEKDEEMEQA 1587
Cdd:pfam10174  487 LQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQkkEECSKLENQLKKAHNAEEAVRTnpeINDRIRLLEQE 566

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1588 KRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ-LDDAVRAND 1666
Cdd:pfam10174  567 VARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKKKGAQlLEEARRRED 646

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1667 DLKENIAiverrnnllQAELEELRAVVEQTersrklaEQELIETSERV----QLLHSQNTSLINQKKKMDADLSqlqtEV 1742
Cdd:pfam10174  647 NLADNSQ---------QLQLEELMGALEKT-------RQELDATKARLsstqQSLAEKDGHLTNLRAERRKQLE----EI 706

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 119586555  1743 EEAVQECRNAEEKAKKA-ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1792
Cdd:pfam10174  707 LEMKQEALLAAISEKDAnIALLELSSSKKKKTQEEVMALKREKDRLVHQLK 757
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
840-1097 2.48e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 55.79  E-value: 2.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLlqeknDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKV 919
Cdd:COG3206   168 LRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLV-----DLSEEAKLLLQQLSELESQLAEARAELAEAEARL 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  920 KEMNERLEDEEEMNAELTAkkrklEDECSELKRDIDDLELTLAkvEKEKHATEN--KVKNLTEEMAGLdeiiakltkeKK 997
Cdd:COG3206   243 AALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEAELA--ELSARYTPNhpDVIALRAQIAAL----------RA 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  998 ALQEAHQQALDDLQAEedkVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRklegDLKLTQESIMDLENDKQQLD 1077
Cdd:COG3206   306 QLQQEAQRILASLEAE---LEALQAREASLQAQLAQLEARLAELPELEAELRRLER----EVEVARELYESLLQRLEEAR 378

                         250       260
                  ....*....|....*....|
gi 119586555 1078 ERLkkkdfELNALNARIEDE 1097
Cdd:COG3206   379 LAE-----ALTVGNVRVIDP 393
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1620-1837 2.72e-07

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 55.22  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1620 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 1699
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1700 rklAEQELIETSERVQLLHSQNTS-LINQKKKMDAdLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEqdtsa 1778
Cdd:COG3883    95 ---LYRSGGSVSYLDVLLGSESFSdFLDRLSALSK-IADADADLLEELKADKAELEAKKAELEAKLAELEALKAE----- 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 119586555 1779 hLERMKKNMEQTIKDLQHRLDEAEQialkggkkQLQKLEARVRELENELEAEQKRNAES 1837
Cdd:COG3883   166 -LEAAKAELEAQQAEQEALLAQLSA--------EEAAAEAQLAELEAELAAAEAAAAAA 215
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 849-1322 2.86e-07

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 55.96  E-value: 2.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  849 MASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQliknkiqleakvkemNERLED 928
Cdd:PRK10246  428 LVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADVKTICEQ---------------EARIKD 492

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  929 EEEMNAELTAKK----------------RKLEDECSELKRdiDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 992
Cdd:PRK10246  493 LEAQRAQLQAGQpcplcgstshpaveayQALEPGVNQSRL--DALEKEVKKLGEEGAALRGQLDALTKQLQRDESEAQSL 570

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  993 TKEKKALQEAHQQALDDL---QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRmDLERAKRKLEGDLKLTQESimdL 1069
Cdd:PRK10246  571 RQEEQALTQQWQAVCASLnitLQPQDDIQPWLDAQEEHERQLRLLSQRHELQGQIA-AHNQQIIQYQQQIEQRQQQ---L 646

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1070 ENDKQQLDERLKKKDFELNALNARiEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1149
Cdd:PRK10246  647 LTALAGYALTLPQEDEEASWLATR-QQEAQSWQQRQNELTALQNRIQQLTPLLETLPQSDDLPHSEETVALDNWRQVHEQ 725

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1150 leeaggATSVQIEMNKKREAEFQKMRRdLEEATLQHEATAAALRkkHADSVAELGEQIDNLQRvkQKLEKEKSEFKLELD 1229
Cdd:PRK10246  726 ------CLSLHSQLQTLQQQDVLEAQR-LQKAQAQFDTALQASV--FDDQQAFLAALLDEETL--TQLEQLKQNLENQRQ 794

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1230 DVTSNMEQIIKAKAANLEKMCRTLEDQmnehrSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLtrgkLTY 1309
Cdd:PRK10246  795 QAQTLVTQTAQALAQHQQHRPDGLDLT-----VTVEQIQQELAQLAQQLRENTTRQGEIRQQLKQDADNRQQQ----QAL 865

                         490
                  ....*....|...
gi 119586555 1310 TQQLEDLKRQLEE 1322
Cdd:PRK10246  866 MQQIAQATQQVED 878
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 841-1273 4.11e-07

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 55.11  E-value: 4.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   841 KSAEREkEMASMKE----EFTRLKEALEKSEA---RRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI 913
Cdd:pfam05483  389 KSSELE-EMTKFKNnkevELEELKKILAEDEKlldEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEE 467

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   914 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 993
Cdd:pfam05483  468 HYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLR 547

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   994 KEKKALQEAHQQALDDLQAEEDKVntltkakvklEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073
Cdd:pfam05483  548 DELESVREEFIQKGDEVKCKLDKS----------EENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQEN 617

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELqarieeleeeleaERTARAKVEKLRSDLSRELEEISERLEEA 1153
Cdd:pfam05483  618 KALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEI-------------IDNYQKEIEDKKISEEKLLEEVEKAKAIA 684

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1154 GGATSVQIEMNKKREAEFQKMrrdleeatlqheataAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1233
Cdd:pfam05483  685 DEAVKLQKEIDKRCQHKIAEM---------------VALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELS 749

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 119586555  1234 NmeqiIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVND 1273
Cdd:pfam05483  750 N----IKAELLSLKKQLEIEKEEKEKLKMEAKENTAILKD 785
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1352-1588 4.32e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.38  E-value: 4.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1352 TEAKAELQRVLSKANSEVAQwrtkyetdAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMv 1431
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAE--------LEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1432 dvERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1511
Cdd:COG4942    90 --KEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555 1512 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1588
Cdd:COG4942   168 ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 846-1013 4.38e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 53.00  E-value: 4.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKiQLEAKVKEMner 925
Cdd:COG1579    23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNK-EYEALQKEI--- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  926 ledeeemnAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKhatENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1005
Cdd:COG1579    99 --------ESLKRRISDLEDEILELMERIEELEEELAELEAEL---AELEAELEEKKAELDEELAELEAELEELEAEREE 167


                  ....*...
gi 119586555 1006 ALDDLQAE 1013
Cdd:COG1579   168 LAAKIPPE 175
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 835-1200 5.12e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 55.12  E-value: 5.12e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   835 KIKPLLKSAEREKEM-ASMKEEFTRLKEALEKSE-------------ARRKELEEKMVSLLQEKNDLQLQ----VQAEQD 896
Cdd:pfam15921  462 KVSSLTAQLESTKEMlRKVVEELTAKKMTLESSErtvsdltaslqekERAIEATNAEITKLRSRVDLKLQelqhLKNEGD 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   897 NLADAEERCDQLiknKIQLEAK---VKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATEN 973
Cdd:pfam15921  542 HLRNVQTECEAL---KLQMAEKdkvIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDA 618

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   974 KVKNLTEEMAGLDEIIAKLT-------KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQE-KKVR 1045
Cdd:pfam15921  619 KIRELEARVSDLELEKVKLVnagserlRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTtNKLK 698

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1046 MDLERAKRKLEGdlklTQESIMDLENDkqqlderlkkkdfELNALNARIEDEQALGSQlQKKLKELQARIEELEEELEAE 1125
Cdd:pfam15921  699 MQLKSAQSELEQ----TRNTLKSMEGS-------------DGHAMKVAMGMQKQITAK-RGQIDALQSKIQFLEEAMTNA 760

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119586555  1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV 1200
Cdd:pfam15921  761 NKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQEQESV 835
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1001-1162 5.31e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.62  E-value: 5.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1001 EAHQQALDDLQAEEDKVNTLTKAK-------VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESImdlENDK 1073
Cdd:COG1579     3 PEDLRALLDLQELDSELDRLEHRLkelpaelAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARI---KKYE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1074 QQLDERLKKKdfELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA 1153
Cdd:COG1579    80 EQLGNVRNNK--EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAE 157


                  ....*....
gi 119586555 1154 GGATSVQIE 1162
Cdd:COG1579   158 LEELEAERE 166
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 921-1340 8.41e-07

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 53.53  E-value: 8.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   921 EMNERLEDEEEMNAELTAKKRKLEDECSEL---KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
Cdd:pfam19220   14 EMADRLEDLRSLKADFSQLIEPIEAILRELpqaKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVARLA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   998 ALQEAHQQAldDLQAEEDKVNTLTKakvklEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 1077
Cdd:pfam19220   94 KLEAALREA--EAAKEELRIELRDK-----TAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATAR 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1078 ERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARieeleeeleaERTARAKVEKLRSDLSRELEEiSERLEEAggat 1157
Cdd:pfam19220  167 ERLALLEQENRRLQALSEEQAAELAELTRRLAELETQ----------LDATRARLRALEGQLAAEQAE-RERAEAQ---- 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1158 svqiemnkkreaefqkmrRDLEEATLQHEATAAALRKKHADSVAE-----LGEQIDNLQRVK---QKLEKEKSEFKLELD 1229
Cdd:pfam19220  232 ------------------LEEAVEAHRAERASLRMKLEALTARAAateqlLAEARNQLRDRDeaiRAAERRLKEASIERD 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1230 DVTSNMEQiIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQltrGKLTY 1309
Cdd:pfam19220  294 TLERRLAG-LEADLERRTQQFQEMQRARAELEERAEMLTKALAAKDAALERAEERIASLSDRIAELTKRFEV---ERAAL 369

                          410       420       430
                   ....*....|....*....|....*....|..
gi 119586555  1310 TQQLEDLKRQLEEEvKAKNALAH-ALQSARHD 1340
Cdd:pfam19220  370 EQANRRLKEELQRE-RAERALAQgALEIARES 400
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 847-1549 9.33e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 54.19  E-value: 9.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVS------LLQEKNDLQLQVQAEQDNLADAEERcdqliknkiqLEakvk 920
Cdd:COG3096   299 RQLAEEQYRLVEMARELEELSARESDLEQDYQAasdhlnLVQTALRQQEKIERYQEDLEELTER----------LE---- 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  921 EMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL-------------------------------ELTLAKVEKEKH 969
Cdd:COG3096   365 EQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYqqaldvqqtraiqyqqavqalekaralcglpDLTPENAEDYLA 444

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  970 ATENKVKNLTEEMAGLDE--IIAKLTKEK--KALQ------------EAHQQALDDLQAEEDKVNTLTKAkVKLEQQVDD 1033
Cdd:COG3096   445 AFRAKEQQATEEVLELEQklSVADAARRQfeKAYElvckiageversQAWQTARELLRRYRSQQALAQRL-QQLRAQLAE 523

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1034 LEGSLEQEKKVRMDLERAKRKLEGDLkltqESIMDLENDKQQLDERLKKkdfelnaLNARIEDEQALGSQLQKKLKELQA 1113
Cdd:COG3096   524 LEQRLRQQQNAERLLEEFCQRIGQQL----DAAEELEELLAELEAQLEE-------LEEQAAEAVEQRSELRQQLEQLRA 592

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1114 RIEELEEELEAERTARAKVEKLRsdlsrelEEISERLEEAGGATS-VQIEMNKKREAEFQKmrrdlEEATLQHEATAAAL 1192
Cdd:COG3096   593 RIKELAARAPAWLAAQDALERLR-------EQSGEALADSQEVTAaMQQLLEREREATVER-----DELAARKQALESQI 660

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1193 RKKHADSVAE------LGEQ---------------------------------IDNLQRVKQKLEK-------------- 1219
Cdd:COG3096   661 ERLSQPGGAEdprllaLAERlggvllseiyddvtledapyfsalygparhaivVPDLSAVKEQLAGledcpedlyliegd 740

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1220 ----EKSEFKL-ELDD---VTSNMEQI------------IKAKAANLEKMcRTLEDQMNEHRSKA----EETQR---SVN 1272
Cdd:COG3096   741 pdsfDDSVFDAeELEDavvVKLSDRQWrysrfpevplfgRAAREKRLEEL-RAERDELAEQYAKAsfdvQKLQRlhqAFS 819

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1273 DLTSQR-------------AKLQTENGELSRQLDEKEALISQLtrgkltyTQQLEDLKRQLeEEVKAKNALAHALQSARH 1339
Cdd:COG3096   820 QFVGGHlavafapdpeaelAALRQRRSELERELAQHRAQEQQL-------RQQLDQLKEQL-QLLNKLLPQANLLADETL 891

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1340 D--CDLLREQYEEETEAKAELQRvlskanseVAQWRTKYET--DAIQRTEELEEAkkkLAQRLQEAEEAVEAVNAKCSSL 1415
Cdd:COG3096   892 AdrLEELREELDAAQEAQAFIQQ--------HGKALAQLEPlvAVLQSDPEQFEQ---LQADYLQAKEQQRRLKQQIFAL 960

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1416 EKTKHRLQNEIEDlmvDVERSNAAAAALDKKQRnfdKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1495
Cdd:COG3096   961 SEVVQRRPHFSYE---DAVGLLGENSDLNEKLR---ARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQT 1034

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555 1496 LETFKRENKNL------------QEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAE 1549
Cdd:COG3096  1035 LQELEQELEELgvqadaeaeeraRIRRDELHEELSQNRSRRSQLEKQLTRCEAEMDSLQKRLRKAE 1100
PLN02939 PLN02939
transferase, transferring glycosyl groups
 841-1111 1.18e-06

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 53.75  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  841 KSAEREKEMASMKEEFTRLKEALEKS-----EARRKELEEkMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI-- 913
Cdd:PLN02939  118 NSKDGEQLSDFQLEDLVGMIQNAEKNilllnQARLQALED-LEKILTEKEALQGKINILEMRLSETDARIKLAAQEKIhv 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  914 -----QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKekhaTENKVKNLTEEMAGLDEI 988
Cdd:PLN02939  197 eileeQLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAE----TEERVFKLEKERSLLDAS 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  989 IAKLTKEKKALQEAHQQaLDDLQAEE--DKVNTLTKAKVKLEQQVDDLEGSLEQEKkvrmDLERAKRKLEGDL------K 1060
Cdd:PLN02939  273 LRELESKFIVAQEDVSK-LSPLQYDCwwEKVENLQDLLDRATNQVEKAALVLDQNQ----DLRDKVDKLEASLkeanvsK 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 119586555 1061 LTQESIMDLENDKQQLDERLKKKDFElnaLNARIEDEQALGSQLQKKLKEL 1111
Cdd:PLN02939  348 FSSYKVELLQQKLKLLEERLQASDHE---IHSYIQLYQESIKEFQDTLSKL 395
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 1474-1830 1.67e-06

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 52.76  E-value: 1.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1474 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLE 1553
Cdd:pfam19220   21 DLRSLKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1554 HEEGKILRAQLEFNQ---IKAEIERKLAEKDEEME------QAKRNHLRVVDSLQTSLDAETRSRNEALRV----KKKME 1620
Cdd:pfam19220  101 EAEAAKEELRIELRDktaQAEALERQLAAETEQNRaleeenKALREEAQAAEKALQRAEGELATARERLALleqeNRRLQ 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1621 GDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV----RANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1696
Cdd:pfam19220  181 ALSEEQAAELAELTRRLAELETQLDATRARLRALEGQLAAEQaereRAEAQLEEAVEAHRAERASLRMKLEALTARAAAT 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1697 ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEcRNAEEKAKKAITD-AAMMAEELKkeqD 1775
Cdd:pfam19220  261 EQLLAEARNQLRDRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQ-FQEMQRARAELEErAEMLTKALA---A 336

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 119586555  1776 TSAHLERMkknmEQTIKDLQHRLDEAEQIALKggkkQLQKLEARVRELENELEAE 1830
Cdd:pfam19220  337 KDAALERA----EERIASLSDRIAELTKRFEV----ERAALEQANRRLKEELQRE 383
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1669-1932 1.90e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 53.14  E-value: 1.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1669 KENIAIVERRNNLLQAELEELRAVVEQTERSRKlaeqELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1748
Cdd:PRK03918  199 EKELEEVLREINEISSELPELREELEKLEKEVK----ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKE 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1749 CRNAEEKAKKAitdaammaEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQialkggkkQLQKLEARVRELENEle 1828
Cdd:PRK03918  275 IEELEEKVKEL--------KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEE--------EINGIEERIKELEEK-- 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1829 aeqkrnaesvkgmrksERRIKELTYQTEEDRKNLLRLQDLVDKLQlKVKAYKRQAEEAEEQAnTNLSKfRKVQHELDEAE 1908
Cdd:PRK03918  337 ----------------EERLEELKKKLKELEKRLEELEERHELYE-EAKAKKEELERLKKRL-TGLTP-EKLEKELEELE 397

                         250       260
                  ....*....|....*....|....
gi 119586555 1909 ERADIAESQVNKLRAKSRDIGTKR 1932
Cdd:PRK03918  398 KAKEEIEEEISKITARIGELKKEI 421
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 934-1130 2.15e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.14  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  934 AELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ-- 1011
Cdd:COG3883    19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYrs 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1012 -AEEDKVNTLTKAK---------VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLK 1081
Cdd:COG3883    99 gGSVSYLDVLLGSEsfsdfldrlSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQA 178

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 119586555 1082 KKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA 1130
Cdd:COG3883   179 EQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAA 227
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 1246-1447 2.59e-06

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 52.55  E-value: 2.59e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1246 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK 1325
Cdd:pfam09726  400 LEQDIKKLKAELQASRQTEQELRSQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQLEKRLKAEQE 479

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1326 AKNALAHALQSARHdcdllREQYEEETEAKAELQRVLSKANSevaqwrtkyeTDAI-QRTEELEEAKKKLAQRLQEAEEA 1404
Cdd:pfam09726  480 ARASAEKQLAEEKK-----RKKEEEATAARAVALAAASRGEC----------TESLkQRKRELESEIKKLTHDIKLKEEQ 544

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 119586555  1405 VEAVNAKCSSLEKTKHRlQNEIEDLMvdversNAAAAALDKKQ 1447
Cdd:pfam09726  545 IRELEIKVQELRKYKES-EKDTEVLM------SALSAMQDKNQ 580
PRK01156 PRK01156
chromosome segregation protein; Provisional
 883-1532 2.72e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.60  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  883 EKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELtakkRKLEDECSELKRDIDDLELTLA 962
Cdd:PRK01156  139 EMDSLISGDPAQRKKILDEILEINSLERNYDKLKDVIDMLRAEISNIDYLEEKL----KSSNLELENIKKQIADDEKSHS 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  963 KVEKEKHATENKVKNLTEEMAGLDEIIAKLT---KEKKALQEAHQQALDDLQAEEDKVNtltkakvkleqqvdDLEGSLE 1039
Cdd:PRK01156  215 ITLKEIERLSIEYNNAMDDYNNLKSALNELSsleDMKNRYESEIKTAESDLSMELEKNN--------------YYKELEE 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1040 QEKKVRMDLERAKRklegdlkltqESIMDLENDKQQLD---ERLKKKDFELNALNARIedeqalgsqlqKKLKELQArie 1116
Cdd:PRK01156  281 RHMKIINDPVYKNR----------NYINDYFKYKNDIEnkkQILSNIDAEINKYHAII-----------KKLSVLQK--- 336

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1117 eleeeleaERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR---DLEEATLQHEATAAALR 1193
Cdd:PRK01156  337 --------DYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERmsaFISEILKIQEIDPDAIK 408

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1194 KKHadsvAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIikaKAANLEKMCRT------LEDQMNEHRSKAEET 1267
Cdd:PRK01156  409 KEL----NEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEML---NGQSVCPVCGTtlgeekSNHIINHYNEKKSRL 481

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1268 QRSVNDLTSQRAKLqteNGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQ 1347
Cdd:PRK01156  482 EEKIREIEIEVKDI---DEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSL 558

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1348 YEEETEAKAElqrVLSKANSEvaqwRTKYETDAIQ-RTEELEEAKKKLAQRLQEAEEAVEAVNakcSSLEKTKHRLQNEI 1426
Cdd:PRK01156  559 KLEDLDSKRT---SWLNALAV----ISLIDIETNRsRSNEIKKQLNDLESRLQEIEIGFPDDK---SYIDKSIREIENEA 628

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1427 EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKeARSLSTELFKLKNAYEESLEHLETFKRENKNL 1506
Cdd:PRK01156  629 NNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSR-INDIEDNLKKSRKALDDAKANRARLESTIEIL 707

                         650       660
                  ....*....|....*....|....*.
gi 119586555 1507 QEEISDLTEQLGSSGKTIHELEKVRK 1532
Cdd:PRK01156  708 RTRINELSDRINDINETLESMKKIKK 733
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1669-1926 3.26e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.37  E-value: 3.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1669 KENIAIVE--RRNNLLQAELEELRAVVEQ-------TERsRKLAEQELIETSERVQLLHSQNTSLINQKKKMdadlsQLQ 1739
Cdd:TIGR02168  135 KRSYSIIEqgKISEIIEAKPEERRAIFEEaagiskyKER-RKETERKLERTRENLDRLEDILNELERQLKSL-----ERQ 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1740 TEVEEAVQECRNAEEKAKKAItdAAMMAEELKKEQDTsahLERMKKNMEQTIKDLQHRLDEAEQialkggkkQLQKLEAR 1819
Cdd:TIGR02168  209 AEKAERYKELKAELRELELAL--LVLRLEELREELEE---LQEELKEAEEELEELTAELQELEE--------KLEELRLE 275

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1820 VRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK 1899
Cdd:TIGR02168  276 VSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELES 355

                          250       260
                   ....*....|....*....|....*..
gi 119586555  1900 VQHELDEAEERADIAESQVNKLRAKSR 1926
Cdd:TIGR02168  356 LEAELEELEAELEELESRLEELEEQLE 382
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1263-1930 3.57e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 52.36  E-value: 3.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1263 KAEETQRSVndLTSQRAKLQTEngELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAK-NALAHALQSARHDC 1341
Cdd:TIGR00606  186 KALETLRQV--RQTQGQKVQEH--QMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENElDPLKNRLKEIEHNL 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1342 DLLREqYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK----KKLAQRLQEAEEAVEAVNAKCSSLEK 1417
Cdd:TIGR00606  262 SKIMK-LDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHqrtvREKERELVDCQRELEKLNKERRLLNQ 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1418 TKHRLQNEIEDLMVDVER-------------SNAAAAALDKKQRNFDKIlaewKQKYEESQSELESSQKEARSLSTELFK 1484
Cdd:TIGR00606  341 EKTELLVEQGRLQLQADRhqehirardsliqSLATRLELDGFERGPFSE----RQIKNFHTLVIERQEDEAKTAAQLCAD 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1485 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGssgKTIHELEKVRKQLEAEK------MELQSALEEAEASLEHEEGK 1558
Cdd:TIGR00606  417 LQSKERLKQEQADEIRDEKKGLGRTIELKKEILE---KKQEELKFVIKELQQLEgssdriLELDQELRKAERELSKAEKN 493

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1559 -----ILRAQLEFNQIKAEIERKLAEKDEEMEQakrnhlrvvdslqtsLDAETRSRNEALRV-KKKMEGDLNEMEIQLSH 1632
Cdd:TIGR00606  494 sltetLKKEVKSLQNEKADLDRKLRKLDQEMEQ---------------LNHHTTTRTQMEMLtKDKMDKDEQIRKIKSRH 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1633 ANRMAAEA-----QKQV-KSLQSLLKDTQIQLDDAVrandDLKENIAIVERRNNLLQAELEELRAVVEQTER------SR 1700
Cdd:TIGR00606  559 SDELTSLLgyfpnKKQLeDWLHSKSKEINQTRDRLA----KLNKELASLEQNKNHINNELESKEEQLSSYEDklfdvcGS 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1701 KLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECR---NAEEKAKKAITDAAMMAEELKKEQ-DT 1776
Cdd:TIGR00606  635 QDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQrvfQTEAELQEFISDLQSKLRLAPDKLkST 714

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1777 SAHLERMKKNMEQTIKDLQHRLDEAEQIA--LKGGKKQLQKLEARVRELENELEAEQKR------NAESVKGMRKSERRI 1848
Cdd:TIGR00606  715 ESELKKKEKRRDEMLGLAPGRQSIIDLKEkeIPELRNKLQKVNRDIQRLKNDIEEQETLlgtimpEEESAKVCLTDVTIM 794

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1849 KELTYQTEEDRKnllRLQDLVDKLQ-----LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRA 1923
Cdd:TIGR00606  795 ERFQMELKDVER---KIAQQAAKLQgsdldRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKS 871


                   ....*..
gi 119586555  1924 KSRDIGT 1930
Cdd:TIGR00606  872 EKLQIGT 878
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1252-1410 3.60e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 50.31  E-value: 3.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1252 TLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAK--NA 1329
Cdd:COG1579    14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKeyEA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1330 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN 1409
Cdd:COG1579    94 LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKIP 173


                  .
gi 119586555 1410 A 1410
Cdd:COG1579   174 P 174
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1262-1589 3.80e-06

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 51.94  E-value: 3.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1262 SKAEETQRSVNDLTsqRAKLQTENGELSRQLDEKE-----ALISQLTRGKLTYTQQLEDLKRQLEEEV--KAKNALAHAL 1334
Cdd:NF033838   50 SSGNESQKEHAKEV--ESHLEKILSEIQKSLDKRKhtqnvALNKKLSDIKTEYLYELNVLKEKSEAELtsKTKKELDAAF 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1335 QSARHDCDLLREQYEEETEAKAELQRvlsKANSEVAQWRTKYETDAIqRTEELEEAKKKLaqRLQEAEEAVEAVNAKCSS 1414
Cdd:NF033838  128 EQFKKDTLEPGKKVAEATKKVEEAEK---KAKDQKEEDRRNYPTNTY-KTLELEIAESDV--EVKKAELELVKEEAKEPR 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1415 LEKTkhrlqneIEDLMVDVERSNAAAAALDKKQRnfDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1494
Cdd:NF033838  202 DEEK-------IKQAKAKVESKKAEATRLEKIKT--DREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGE 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1495 HLETFKRENKNLQEEISDLTEQLGS----SGKTIHELEK-----------------------VRKQLEAEKMELQSALEE 1547
Cdd:NF033838  273 PATPDKKENDAKSSDSSVGEETLPSpslkPEKKVAEAEKkveeakkkakdqkeedrrnyptnTYKTLELEIAESDVKVKE 352

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 119586555 1548 AEASLEHEEGKILRAQLEFNQIKAEIERKLAE----------KDEEMEQAKR 1589
Cdd:NF033838  353 AELELVKEEAKEPRNEEKIKQAKAKVESKKAEatrlekiktdRKKAEEEAKR 404
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 867-1335 3.94e-06

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 52.06  E-value: 3.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   867 EARRKELEEKMVSLLQEKNDLQLQVQAEQDNLadaeercdQLIKNKIQLEAkvKEMNERLEDEEEMNAELTAKKRKLede 946
Cdd:pfam07111  241 ELERQELLDTMQHLQEDRADLQATVELLQVRV--------QSLTHMLALQE--EELTRKIQPSDSLEPEFPKKCRSL--- 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   947 cseLKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL------ 1020
Cdd:pfam07111  308 ---LNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAELQEQVTSQSQEQAILQRALQDKAAEVEVERMSAKGLqmelsr 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1021 -TKAKVKLEQQVDDLEgslEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKkdfelnalnariedeqa 1099
Cdd:pfam07111  385 aQEARRRQQQQTASAE---EQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSYAVRK----------------- 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1100 lgsqlQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE---RL--EEAGGATSVQIEMNKKREaEFQKM 1174
Cdd:pfam07111  445 -----VHTIKGLMARKVALAQLRQESCPPPPPAPPVDADLSLELEQLREernRLdaELQLSAHLIQQEVGRARE-QGEAE 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1175 RRDLEEATLQHEATAaalrKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAANLEKMCRT-- 1252
Cdd:pfam07111  519 RQQLSEVAQQLEQEL----QRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQEKVAEVETRLREql 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1253 --LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEalisqltrgkltyTQQLEDLKRQLEEEVKAKNAL 1330
Cdd:pfam07111  595 sdTKRRLNEARREQAKAVVSLRQIQHRATQEKERNQELRRLQDEAR-------------KEEGQRLARRVQELERDKNLM 661


                   ....*
gi 119586555  1331 AHALQ 1335
Cdd:pfam07111  662 LATLQ 666
mukB PRK04863
chromosome partition protein MukB;
1042-1869 4.32e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 52.27  E-value: 4.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1042 KKVRMDLERAKRKLegdlKLTQESIMDLENDKQQLDERLKK------KDFELNALNARIEDEQALGSQlqkklKELQAri 1115
Cdd:PRK04863  229 RKAFQDMEAALREN----RMTLEAIRVTQSDRDLFKHLITEstnyvaADYMRHANERRVHLEEALELR-----RELYT-- 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1116 eeleeeleaERTARAKVEKLRSDLSRELEEISER---LEEAGGATS--VQIEMNKKREAE-FQKMRRDLEEATLQHEATA 1189
Cdd:PRK04863  298 ---------SRRQLAAEQYRLVEMARELAELNEAesdLEQDYQAASdhLNLVQTALRQQEkIERYQADLEELEERLEEQN 368

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1190 AAlrkkhadsVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME-------QIIKAKAAnLEK---MCRT------- 1252
Cdd:PRK04863  369 EV--------VEEADEQQEENEARAEAAEEEVDELKSQLADYQQALDvqqtraiQYQQAVQA-LERakqLCGLpdltadn 439

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1253 LEDQMNEHRSKAEETQRSVNDL-----TSQRAKLQTENG---------------------ELSRQLDEKEALISQLTRGK 1306
Cdd:PRK04863  440 AEDWLEEFQAKEQEATEELLSLeqklsVAQAAHSQFEQAyqlvrkiagevsrseawdvarELLRRLREQRHLAEQLQQLR 519

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1307 ltytQQLEDLKRQLEEEVKAKNALAHALQSARHDCDlLREQYEEETEAKAELQRVLSKANSEVAQWRTKYEtdaiQRTEE 1386
Cdd:PRK04863  520 ----MRLSELEQRLRQQQRAERLLAEFCKRLGKNLD-DEDELEQLQEELEARLESLSESVSEARERRMALR----QQLEQ 590

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1387 LEEAKKKLAQRLQE---AEEAVEAVNAKCSSLEKTKHRLQNEIEDLmvdVERSNAAAAALDKKQRNFDKILAEWKQKYEE 1463
Cdd:PRK04863  591 LQARIQRLAARAPAwlaAQDALARLREQSGEEFEDSQDVTEYMQQL---LERERELTVERDELAARKQALDEEIERLSQP 667

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1464 SQSELESSQKEARSLSTELfkLKNAYEE-SLEH-------------------LETFKRENKNLQEEISDL------TEQL 1517
Cdd:PRK04863  668 GGSEDPRLNALAERFGGVL--LSEIYDDvSLEDapyfsalygparhaivvpdLSDAAEQLAGLEDCPEDLyliegdPDSF 745

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1518 GSSGKTIHELEK----------VR----------------KQLEAEKMELQSaLEEAEASLEHEEGKILRAQLEFNQIKA 1571
Cdd:PRK04863  746 DDSVFSVEELEKavvvkiadrqWRysrfpevplfgraareKRIEQLRAEREE-LAERYATLSFDVQKLQRLHQAFSRFIG 824

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1572 E-IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMeiqLSHANRMAAEaqkqvkSLQSL 1650
Cdd:PRK04863  825 ShLAVAFEADPEAELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRL---LPRLNLLADE------TLADR 895

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1651 LKDTQIQLDDAVRANDDLKEN---IAIVERRNNLLQA---ELEELRAVVEQTERSRKLAEQELIETSERVQLLH----SQ 1720
Cdd:PRK04863  896 VEEIREQLDEAEEAKRFVQQHgnaLAQLEPIVSVLQSdpeQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAhfsyED 975

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1721 NTSLINQkkkmDADLS-QLQTEVEEAVQECRNAEEKAKKA---ITDAAMMAEELKKEQDTsahLERMKKNMEQTIKDLQH 1796
Cdd:PRK04863  976 AAEMLAK----NSDLNeKLRQRLEQAEQERTRAREQLRQAqaqLAQYNQVLASLKSSYDA---KRQMLQELKQELQDLGV 1048

                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555 1797 RLDEAEQIALKGGKKQLQKLEARVRELENELEAE---QKRNAES-VKGMRKSERRIKELTYQTEEDRKNLLRLQDLV 1869
Cdd:PRK04863 1049 PADSGAEERARARRDELHARLSANRSRRNQLEKQltfCEAEMDNlTKKLRKLERDYHEMREQVVNAKAGWCAVLRLV 1125
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1350-1910 4.34e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.03  E-value: 4.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1350 EETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL-AQR--LQEAEEAVEAVNAKCSSLEKTKHRL--QN 1424
Cdd:pfam05483   71 ENSEGLSRLYSKLYKEAEKIKKWKVSIEAELKQKENKLQENRKIIeAQRkaIQELQFENEKVSLKLEEEIQENKDLikEN 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1425 EIEDLMVDVERSNAAAAALDKKQRNFDKilAEWKQKYEESQSELESSQKEARSLSTEL--------FKLKNAYEEsLEHL 1496
Cdd:pfam05483  151 NATRHLCNLLKETCARSAEKTKKYEYER--EETRQVYMDLNNNIEKMILAFEELRVQAenarlemhFKLKEDHEK-IQHL 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1497 ET-FKRENKNLQEEIS--------------DLTEQLGSSGKTIHELEKVRK-------QLEAEKMELQSALEEAEASLEH 1554
Cdd:pfam05483  228 EEeYKKEINDKEKQVSllliqitekenkmkDLTFLLEESRDKANQLEEKTKlqdenlkELIEKKDHLTKELEDIKMSLQR 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1555 EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ---AKRNHLRVVdslqTSLDAETRSRNEALRV-KKKMEGDLNEMEIql 1630
Cdd:pfam05483  308 SMSTQKALEEDLQIATKTICQLTEEKEAQMEElnkAKAAHSFVV----TEFEATTCSLEELLRTeQQRLEKNEDQLKI-- 381

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1631 shanrMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERrNNLLQAELEELRAVVEQTERSRKLAEQELIET 1710
Cdd:pfam05483  382 -----ITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDE-KKQFEKIAEELKGKEQELIFLLQAREKEIHDL 455

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1711 SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMeqt 1790
Cdd:pfam05483  456 EIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERM--- 532

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1791 ikdlqhrldeaeqialkggKKQLQKLEARVRELENELEA---EQKRNAESVK-GMRKSERRIKELTYQTEEDRKNLLRLQ 1866
Cdd:pfam05483  533 -------------------LKQIENLEEKEMNLRDELESvreEFIQKGDEVKcKLDKSEENARSIEYEVLKKEKQMKILE 593

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 119586555  1867 DL--------------VDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER 1910
Cdd:pfam05483  594 NKcnnlkkqienknknIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQK 651
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1274-1698 4.41e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 51.43  E-value: 4.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1274 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAknaLAHALQSARHDCDLLREQYEEETE 1353
Cdd:pfam07888   32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAE---LKEELRQSREKHEELEEKYKELSA 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1354 AKAELqrvlskanSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1433
Cdd:pfam07888  109 SSEEL--------SEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKL 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1434 ERSnaaaaaldkkqrnfdkilaewkqkyeesqselessQKEARSLSTELFKLKNAYEESLEHLETfkrenknLQEEISDL 1513
Cdd:pfam07888  181 QQT-----------------------------------EEELRSLSKEFQELRNSLAQRDTQVLQ-------LQDTITTL 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1514 TEQLGSSGKTIHELEKVRKqleaekmELQSALEEAEASLEHEEGkilraqlefnqIKAEIERKLAEKDEEMEQAKRNHLR 1593
Cdd:pfam07888  219 TQKLTTAHRKEAENEALLE-------ELRSLQERLNASERKVEG-----------LGEELSSMAAQRDRTQAELHQARLQ 280

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1594 VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ--------------IQLD 1659
Cdd:pfam07888  281 AAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEERMEREklevelgrekdcnrVQLS 360

                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 119586555  1660 DAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER 1698
Cdd:pfam07888  361 ESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQ 399
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 1240-1885 5.46e-06

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 51.72  E-value: 5.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1240 KAKAANLEKmcrtLEDQMNEHRSKAEETQRSVND----LTSQRAKLQTENGELSRQ---LDEKEALISQLTRgkltyTQQ 1312
Cdd:PRK10246  194 KSARTELEK----LQAQASGVALLTPEQVQSLTAslqvLTDEEKQLLTAQQQQQQSlnwLTRLDELQQEASR-----RQQ 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1313 LedLKRQLEEEVKAKNALAhALQSARHDCDL--LREQYEEETEAKAELQRVLSKANS---EVAQWRTKYETDAIQRTEEL 1387
Cdd:PRK10246  265 A--LQQALAAEEKAQPQLA-ALSLAQPARQLrpHWERIQEQSAALAHTRQQIEEVNTrlqSTMALRARIRHHAAKQSAEL 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1388 EEAKKKLAQRLQEAE------EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA------------AAAALDK--KQ 1447
Cdd:PRK10246  342 QAQQQSLNTWLAEHDrfrqwnNELAGWRAQFSQQTSDREQLRQWQQQLTHAEQKLNAlpaitltltadeVAAALAQhaEQ 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1448 RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKnayeeslEHLETFKRENKNLQEEISDLteqlgssgKTIHEL 1527
Cdd:PRK10246  422 RPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRN-------AALNEMRQRYKEKTQQLADV--------KTICEQ 486

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1528 EKVRKQLEAEKMELQS-------------------------------ALEEAEASLEhEEGKILRAQLE--FNQIK---- 1570
Cdd:PRK10246  487 EARIKDLEAQRAQLQAgqpcplcgstshpaveayqalepgvnqsrldALEKEVKKLG-EEGAALRGQLDalTKQLQrdes 565

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1571 -----AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEgdlneMEIQLSHANRMAAEAQKQVK 1645
Cdd:PRK10246  566 eaqslRQEEQALTQQWQAVCASLNITLQPQDDIQPWLDAQEEHERQLRLLSQRHE-----LQGQIAAHNQQIIQYQQQIE 640

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1646 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL-----AEQELIETSERVQL---- 1716
Cdd:PRK10246  641 QRQQQLLTALAGYALTLPQEDEEASWLATRQQEAQSWQQRQNELTALQNRIQQLTPLletlpQSDDLPHSEETVALdnwr 720

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1717 -LHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK---AKKAITDAAMMAEElkkeqdTSAHLERMKKNMEQTIK 1792
Cdd:PRK10246  721 qVHEQCLSLHSQLQTLQQQDVLEAQRLQKAQAQFDTALQAsvfDDQQAFLAALLDEE------TLTQLEQLKQNLENQRQ 794

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1793 DLQHRLDEAEQialkggkKQLQKLEARVRELENELEAE--QKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVd 1870
Cdd:PRK10246  795 QAQTLVTQTAQ-------ALAQHQQHRPDGLDLTVTVEqiQQELAQLAQQLRENTTRQGEIRQQLKQDADNRQQQQALM- 866

                         730
                  ....*....|....*
gi 119586555 1871 klqLKVKAYKRQAEE 1885
Cdd:PRK10246  867 ---QQIAQATQQVED 878
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 860-1682 5.70e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 51.98  E-value: 5.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   860 KEALEK--SEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA------------DAEERCDQLIKN----KIQLEAKVKE 921
Cdd:TIGR01612  976 INELDKafKDASLNDYEAKNNELIKYFNDLKANLGKNKENMLyhqfdekekatnDIEQKIEDANKNipniEIAIHTSIYN 1055

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   922 MNERLEDEEEMNAELTAKK--RKLEDECSELKRDIDDLEL----TLAKVEKEKHATE-NKVKNlteEMAGLDEIIAKLTK 994
Cdd:TIGR01612 1056 IIDEIEKEIGKNIELLNKEilEEAEINITNFNEIKEKLKHynfdDFGKEENIKYADEiNKIKD---DIKNLDQKIDHHIK 1132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   995 EKKALQEAHQQALDDLQAEEDKVNTLTKAKVkleqQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQEsIMDLENDK- 1073
Cdd:TIGR01612 1133 ALEEIKKKSENYIDEIKAQINDLEDVADKAI----SNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNE-IAEIEKDKt 1207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1074 ---------------------QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAeRTARAKV 1132
Cdd:TIGR01612 1208 sleevkginlsygknlgklflEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMETF-NISHDDD 1286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1133 EKLRSDLSRELEEISERLEEaggatSVQIEMNKKREAEFQKMRRDLEEATLQHEataaalrkKHADSVAELGEQIDN--- 1209
Cdd:TIGR01612 1287 KDHHIISKKHDENISDIREK-----SLKIIEDFSEESDINDIKKELQKNLLDAQ--------KHNSDINLYLNEIANiyn 1353

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1210 ---LQRVKQKLEKEKsEFKLELDDVTSNmeqiIKAKAANLEKMCRTLEDQMN--EHRSKAEETQ---------RSVNDLT 1275
Cdd:TIGR01612 1354 ilkLNKIKKIIDEVK-EYTKEIEENNKN----IKDELDKSEKLIKKIKDDINleECKSKIESTLddkdideciKKIKELK 1428

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1276 SQRAKLQTENGELSRQLDEKEALISQLTRgkltyTQQLEDLKRQLEEEVKAKNAlahalqSARHDCDL--LREQYEEETE 1353
Cdd:TIGR01612 1429 NHILSEESNIDTYFKNADENNENVLLLFK-----NIEMADNKSQHILKIKKDNA------TNDHDFNIneLKEHIDKSKG 1497

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1354 AKAELQR----------VLSKANSEVAQWRTKYETDAIQrtEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQ 1423
Cdd:TIGR01612 1498 CKDEADKnakaieknkeLFEQYKKDVTELLNKYSALAIK--NKFAKTKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIK 1575

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1424 NE---IEDLMVDVERSNAAAAALDKKQRNFDkilaewkqkyeesqselessqkearslsTELFKLKNAYEESLEHLetfk 1500
Cdd:TIGR01612 1576 KEkfrIEDDAAKNDKSNKAAIDIQLSLENFE----------------------------NKFLKISDIKKKINDCL---- 1623

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1501 RENKNLQEEISDLT-----EQLGSSGKTIHELEKVRKQLEAEKMELqsalEEAEASLEHEEGKILRAQLEFNQIKAEIER 1575
Cdd:TIGR01612 1624 KETESIEKKISSFSidsqdTELKENGDNLNSLQEFLESLKDQKKNI----EDKKKELDELDSEIEKIEIDVDQHKKNYEI 1699

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1576 KLAEKDEEMEQAKRNHL------------RVVDSLQTSlDAETRSRNEALRVKKKMEGDLNEMEIQLSH--ANRMAAEAQ 1641
Cdd:TIGR01612 1700 GIIEKIKEIAIANKEEIesikelieptieNLISSFNTN-DLEGIDPNEKLEEYNTEIGDIYEEFIELYNiiAGCLETVSK 1778

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|.
gi 119586555  1642 KQVKSLQslLKDTQIQlddavrANDDLKENIAIVERRNNLL 1682
Cdd:TIGR01612 1779 EPITYDE--IKNTRIN------AQNEFLKIIEIEKKSKSYL 1811
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1438-1678 7.43e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.53  E-value: 7.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1438 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQl 1517
Cdd:COG4942    13 LAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKE- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1518 gssgktiheLEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI--KAEIERKLAEKDEEMEQAKRNHLRVV 1595
Cdd:COG4942    92 ---------IAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAvrRLQYLKYLAPARREQAEELRADLAEL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1596 DSLQTSLDAEtrsrnealrvKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1675
Cdd:COG4942   163 AALRAELEAE----------RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232


                  ...
gi 119586555 1676 ERR 1678
Cdd:COG4942   233 EAE 235
Filament pfam00038
Intermediate filament protein;
1311-1579 9.04e-06

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 49.92  E-value: 9.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1311 QQLEDLKRQLEEEVKAKNALAHALQSARHDC-----DLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE 1385
Cdd:pfam00038   21 RFLEQQNKLLETKISELRQKKGAEPSRLYSLyekeiEDLRRQLDTLTVERARLQLELDNLRLAAEDFRQKYEDELNLRTS 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1386 eLEEAKKKLAQRLQEAEEAVEAVNAKCSSLE------KTKHR-----LQNEIEDLMVDVERSNAaaaaldkKQRNFDKIL 1454
Cdd:pfam00038  101 -AENDLVGLRKDLDEATLARVDLEAKIESLKeelaflKKNHEeevreLQAQVSDTQVNVEMDAA-------RKLDLTSAL 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1455 AEWKQKYEEsqselessqkearslstelfkLKNAYEESLEhlETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL 1534
Cdd:pfam00038  173 AEIRAQYEE---------------------IAAKNREEAE--EWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSL 229

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555  1535 EAE-------KMELQSALEEAEASLEHE----EGKILRAQLEFNQIKAEIERKLAE 1579
Cdd:pfam00038  230 EIElqslkkqKASLERQLAETEERYELQladyQELISELEAELQETRQEMARQLRE 285
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1011-1193 9.75e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.79  E-value: 9.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1011 QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQ-EKKvrmdLERAKRK-----LEGDLKLTQESIMDLENDKQQLDERLKKKD 1084
Cdd:COG3206   164 QNLELRREEARKALEFLEEQLPELRKELEEaEAA----LEEFRQKnglvdLSEEAKLLLQQLSELESQLAEARAELAEAE 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1085 FELNALNARIED---------EQALGSQLQKKLKELQARIEELEEELEAE----RTARAKVEKLRSDLSRELEEISERLE 1151
Cdd:COG3206   240 ARLAALRAQLGSgpdalpellQSPVIQQLRAQLAELEAELAELSARYTPNhpdvIALRAQIAALRAQLQQEAQRILASLE 319

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 119586555 1152 eaggatsVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1193
Cdd:COG3206   320 -------AELEALQAREASLQAQLAQLEARLAELPELEAELR 354
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1486-1921 9.96e-06

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 50.60  E-value: 9.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1486 KNAYEEsLEHLETFKRE--NKNLQEEISDLtEQLGSSGKTIHELEKVRKQ----------------LEAEK-------ME 1540
Cdd:PRK04778   25 KRNYKR-IDELEERKQEleNLPVNDELEKV-KKLNLTGQSEEKFEEWRQKwdeivtnslpdieeqlFEAEElndkfrfRK 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1541 LQSALEEAEASLEHEEGKILRAQLEFNQIKaEIERKLaekDEEMEQAKRNHlrvvDSLQTSLDAETRSRNEALrvkKKME 1620
Cdd:PRK04778  103 AKHEINEIESLLDLIEEDIEQILEELQELL-ESEEKN---REEVEQLKDLY----RELRKSLLANRFSFGPAL---DELE 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1621 GDLNEMEIQLSHANRMAA-----EAQKQVKSLQSLLKDTQIQLDDavranddlkenI-AIVERRNNLLQAELEELRAVVE 1694
Cdd:PRK04778  172 KQLENLEEEFSQFVELTEsgdyvEAREILDQLEEELAALEQIMEE-----------IpELLKELQTELPDQLQELKAGYR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1695 Q-TERSRKLAEQELIETSERVQLLHSQNTSLINQ-------------KKKMDADLSQLQTEVEeavqeCRNAEEKAKKAI 1760
Cdd:PRK04778  241 ElVEEGYHLDHLDIEKEIQDLKEQIDENLALLEEldldeaeekneeiQERIDQLYDILEREVK-----ARKYVEKNSDTL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1761 TDAAMMAEELKKEqdTSAHLERMKKN-------------MEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELENEL 1827
Cdd:PRK04778  316 PDFLEHAKEQNKE--LKEEIDRVKQSytlneselesvrqLEKQLESLEKQYDEITE-RIAEQEIAYSELQEELEEILKQL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1828 ---EAEQKRNAESVKGMRKSERRIKEltyQTEEDRKNLLRLQDLVDKLQL-----KVKAYKRQAEEAEEQANTNLSKFR- 1898
Cdd:PRK04778  393 eeiEKEQEKLSEMLQGLRKDELEARE---KLERYRNKLHEIKRYLEKSNLpglpeDYLEMFFEVSDEIEALAEELEEKPi 469

                         490       500
                  ....*....|....*....|....*.
gi 119586555 1899 ---KVQHELDEAEERADIAESQVNKL 1921
Cdd:PRK04778  470 nmeAVNRLLEEATEDVETLEEETEEL 495
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1311-1907 1.19e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 50.72  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1311 QQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR---------EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1381
Cdd:COG3096   306 YRLVEMARELEELSARESDLEQDYQAASDHLNLVQtalrqqekiERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLE 385

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1382 QRTEELEEAKKKLA--------------------QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL---MVDVER--- 1435
Cdd:COG3096   386 AAEEEVDSLKSQLAdyqqaldvqqtraiqyqqavQALEKARALCGLPDLTPENAEDYLAAFRAKEQQAteeVLELEQkls 465

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1436 -SNAAAAALDKKQRNFDKILAE------WKQkyeesqseLESSQKEARSLSTELFKLkNAYEESLEHLETFKRENKNLQE 1508
Cdd:COG3096   466 vADAARRQFEKAYELVCKIAGEversqaWQT--------ARELLRRYRSQQALAQRL-QQLRAQLAELEQRLRQQQNAER 536

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1509 EISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEA---SLEHEEGKiLRAQLEFNQIKAEIERKLAEK----D 1581
Cdd:COG3096   537 LLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEqrsELRQQLEQ-LRARIKELAARAPAWLAAQDAlerlR 615

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1582 EEMEQAKRNHLRVVDSLQTSLDAE---TRSRNEALRVKKKMEGDLNEmeiqLSHAN-----RMAAEAQKQVKSLQSLLKD 1653
Cdd:COG3096   616 EQSGEALADSQEVTAAMQQLLEREreaTVERDELAARKQALESQIER----LSQPGgaedpRLLALAERLGGVLLSEIYD 691

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1654 tQIQLDDA-------------------------VRANDDLKENIAIVERR-----NNLLQAELEELRAVVEQTERS---- 1699
Cdd:COG3096   692 -DVTLEDApyfsalygparhaivvpdlsavkeqLAGLEDCPEDLYLIEGDpdsfdDSVFDAEELEDAVVVKLSDRQwrys 770

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1700 ---------RKLAEQELIETSE-----------------RVQLLHSQNTSLINQKKKM--DAD-------LSQLQTEVEE 1744
Cdd:COG3096   771 rfpevplfgRAAREKRLEELRAerdelaeqyakasfdvqKLQRLHQAFSQFVGGHLAVafAPDpeaelaaLRQRRSELER 850

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1745 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLErmKKNMEQTIKDLQHRLDEAEQ----IALKGgkKQLQKLEARV 1820
Cdd:COG3096   851 ELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPQANLLA--DETLADRLEELREELDAAQEaqafIQQHG--KALAQLEPLV 926

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1821 RELEN-------------ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRknLLRLQDLVDKLQLKVkaykRQAEEAE 1887
Cdd:COG3096   927 AVLQSdpeqfeqlqadylQAKEQQRRLKQQIFALSEVVQRRPHFSYEDAVGL--LGENSDLNEKLRARL----EQAEEAR 1000

                         730       740
                  ....*....|....*....|
gi 119586555 1888 EQANTNLskfRKVQHELDEA 1907
Cdd:COG3096  1001 REAREQL---RQAQAQYSQY 1017
mukB PRK04863
chromosome partition protein MukB;
1258-1929 1.20e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 50.73  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1258 NEHRSKAEETQRSVNDLTSQRAKLQTEN---GELSRQLDEKEALISQLTrgkltytQQLEDLKRQLEeevKAKNALAHAL 1334
Cdd:PRK04863  279 NERRVHLEEALELRRELYTSRRQLAAEQyrlVEMARELAELNEAESDLE-------QDYQAASDHLN---LVQTALRQQE 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1335 QSARHDCDL--LREQYEEETEAKAElqrvlskANSEVAQWRTKYEtdaiQRTEELEEAKKKLA---QRL----------Q 1399
Cdd:PRK04863  349 KIERYQADLeeLEERLEEQNEVVEE-------ADEQQEENEARAE----AAEEEVDELKSQLAdyqQALdvqqtraiqyQ 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1400 EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE----- 1474
Cdd:PRK04863  418 QAVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSeawdv 497

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1475 ARSLSTELFKLKN------AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA 1548
Cdd:PRK04863  498 ARELLRRLREQRHlaeqlqQLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEA 577

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1549 easleHEEGKILRAQLEfnQIKAEIERKLAEKDEEME-QAKRNHLR------------VVDSLQTSLDAE---TRSRNEA 1612
Cdd:PRK04863  578 -----RERRMALRQQLE--QLQARIQRLAARAPAWLAaQDALARLReqsgeefedsqdVTEYMQQLLERErelTVERDEL 650

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1613 LRVKKKMEGDLNEmeiqLSHAN-----RMAAEAQKQVKSLQSLLKDtQIQLDDA---------------VR--------- 1663
Cdd:PRK04863  651 AARKQALDEEIER----LSQPGgsedpRLNALAERFGGVLLSEIYD-DVSLEDApyfsalygparhaivVPdlsdaaeql 725

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1664 -ANDDLKENIAIVER-----RNNLLQAELEElRAVV----------------------------EQTERSRKLAEQELIE 1709
Cdd:PRK04863  726 aGLEDCPEDLYLIEGdpdsfDDSVFSVEELE-KAVVvkiadrqwrysrfpevplfgraarekriEQLRAEREELAERYAT 804

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1710 TSERVQL---LHSQNTSLINQK-------------KKMDADLSQLQTEV---EEAVQECRNAEEKAKKAITDAAMMAEEL 1770
Cdd:PRK04863  805 LSFDVQKlqrLHQAFSRFIGSHlavafeadpeaelRQLNRRRVELERALadhESQEQQQRSQLEQAKEGLSALNRLLPRL 884

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1771 KKEQDTSaHLERmkknmeqtIKDLQHRLDEAEQ----IALKGGK-KQLQKLEARVRELENELEAEQKRNAESVKGMRKSE 1845
Cdd:PRK04863  885 NLLADET-LADR--------VEEIREQLDEAEEakrfVQQHGNAlAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAK 955

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1846 RRIKELTYQTE-------EDRKNLL-RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQ 1917
Cdd:PRK04863  956 QQAFALTEVVQrrahfsyEDAAEMLaKNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQM 1035

                         810
                  ....*....|..
gi 119586555 1918 VNKLRAKSRDIG 1929
Cdd:PRK04863 1036 LQELKQELQDLG 1047
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1745-1928 1.44e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1745 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELE 1824
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQ-ELAALEAELAELEKEIAELR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1825 NELEAEQKRNAESVKGMRKSERR---------------IKELTY----------QTEEDRKNLLRLQDLVDKLQLKVKAY 1879
Cdd:COG4942    97 AELEAQKEELAELLRALYRLGRQpplalllspedfldaVRRLQYlkylaparreQAEELRADLAELAALRAELEAERAEL 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 119586555 1880 KRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1928
Cdd:COG4942   177 EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
MutS2 COG1193
dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];
1048-1202 1.45e-05

dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];


Pssm-ID: 440806 [Multi-domain]  Cd Length: 784  Bit Score: 50.14  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKkkdfELNALNARIEDEQAlgsQLQKKLKELQARieeleeELEAERT 1127
Cdd:COG1193   502 IERARELLGEESIDVEKLIEELERERRELEEERE----EAERLREELEKLRE---ELEEKLEELEEE------KEEILEK 568

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119586555 1128 ARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1202
Cdd:COG1193   569 AREEAEEILREARKEAEELIRELREA-----------QAEEEELKEARKKLEELKQELEEKLEKPKKKAKPAKPP 632
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1382-1612 1.58e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1382 QRTEELEEAKKKLAQ---RLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 1458
Cdd:COG4942    24 EAEAELEQLQQEIAElekELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQK 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1459 QKYeesQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLgssgktiHELEKVRKQLEAEK 1538
Cdd:COG4942   104 EEL---AELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADL-------AELAALRAELEAER 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119586555 1539 MELQSALEEAEAslehEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQtSLDAETRSRNEA 1612
Cdd:COG4942   174 AELEALLAELEE----ERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA-RLEAEAAAAAER 242
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1433-1835 1.62e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.77  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1433 VERSNAAAAALDKKQRNFDKILAEwKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEhLETFKRENKNLQEEISD 1512
Cdd:COG4717    73 LKELEEELKEAEEKEEEYAELQEE-LEELEEELEELEAELEELREELEKLEKLLQLLPLYQE-LEALEAELAELPERLEE 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1513 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL 1592
Cdd:COG4717   151 LEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1593 RVVDSLQTSLDAETRSRNEAL------------RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1660
Cdd:COG4717   231 QLENELEAAALEERLKEARLLlliaaallallgLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQAL 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1661 AVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ--ELIETSERVQLLHSQNTSLINQKKKMDADLSQL 1738
Cdd:COG4717   311 PALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREaeELEEELQLEELEQEIAALLAEAGVEDEEELRAA 390

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1739 QTEVEEAVQ---ECRNAEEKAKKAITDAAMMAEELKKEQ--DTSAHLERMKKNMEQTIKDLQHRLDEAE-QIALKGGKKQ 1812
Cdd:COG4717   391 LEQAEEYQElkeELEELEEQLEELLGELEELLEALDEEEleEELEELEEELEELEEELEELREELAELEaELEQLEEDGE 470

                         410       420
                  ....*....|....*....|...
gi 119586555 1813 LQKLEARVRELENELEAEQKRNA 1835
Cdd:COG4717   471 LAELLQELEELKAELRELAEEWA 493
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1473-1931 1.63e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 50.11  E-value: 1.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1473 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL 1552
Cdd:pfam05483  120 KAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAF 199

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1553 EHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 1632
Cdd:pfam05483  200 EELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKL 279

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1633 ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE 1712
Cdd:pfam05483  280 QDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTC 359

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1713 RVQ-LLHSQNTSLIN---QKKKMDADLSQLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQDTSahlERMKK 1785
Cdd:pfam05483  360 SLEeLLRTEQQRLEKnedQLKIITMELQKKSSELEEMTKFKNNKEvelEELKKILAEDEKLLDEKKQFEKIA---EELKG 436

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1786 NMEQTIKDLQHRLDEAE--QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLL 1863
Cdd:pfam05483  437 KEQELIFLLQAREKEIHdlEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELK 516

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119586555  1864 RLQDLVDKLQLKVKAYKRQAE---EAEEQANTNLSKFRK--------VQHELDEAEERADIAESQVNKLRAKSRDIGTK 1931
Cdd:pfam05483  517 KHQEDIINCKKQEERMLKQIEnleEKEMNLRDELESVREefiqkgdeVKCKLDKSEENARSIEYEVLKKEKQMKILENK 595
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1091-1646 1.69e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 49.74  E-value: 1.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELE----EISERLEEAGGATSVQIEMNKK 1166
Cdd:pfam05557    1 RAELIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQkrirLLEKREAEAEEALREQAELNRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1167 REAEFQKMRRDLEEATLQhEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDdvtsnmeqIIKAKAANL 1246
Cdd:pfam05557   81 KKKYLEALNKKLNEKESQ-LADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLD--------LLKAKASEA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1247 EKMCRTLEDQMNEhrskaeetqrsvndLTSQRAKLQTENGELSRQLDEKEalISQLTRGKLTYTQQLEDLKRQLEEEVKa 1326
Cdd:pfam05557  152 EQLRQNLEKQQSS--------------LAEAEQRIKELEFEIQSQEQDSE--IVKNSKSELARIPELEKELERLREHNK- 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1327 knalahALQSARHDCDLLREQ----------YEEETEAKAELQRVLSKANSEVAQWRTKYETDA--IQRTEELEEAKKKL 1394
Cdd:pfam05557  215 ------HLNENIENKLLLKEEvedlkrklerEEKYREEAATLELEKEKLEQELQSWVKLAQDTGlnLRSPEDLSRRIEQL 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1395 AQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE-------IEDLMVDVERSNAAAAALDK------KQRNFDKILAEWKQKY 1461
Cdd:pfam05557  289 QQREIVLKEENSSLTSSARQLEKARRELEQElaqylkkIEDLNKKLKRHKALVRRLQRrvllltKERDGYRAILESYDKE 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1462 EESQSELESSQKEARSLSTELFKLKNAYEES-------LEHLETFKRENKNLQEEISDLTEQ-----LGSSGKTIHELEK 1529
Cdd:pfam05557  369 LTMSNYSPQLLERIEEAEDMTQKMQAHNEEMeaqlsvaEEELGGYKQQAQTLERELQALRQQesladPSYSKEEVDSLRR 448

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1530 VRKQLEAEKMELQSALEEAEASLEHEEgkiLRAQLEFNQIKAeierkLAEKDEEMEQAKRNHLRVVDSLQTSLDAeTRSR 1609
Cdd:pfam05557  449 KLETLELERQRLREQKNELEMELERRC---LQGDYDPKKTKV-----LHLSMNPAAEAYQQRKNQLEKLQAEIER-LKRL 519

                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 119586555  1610 NEALRVKKKMEGDLNEMEIQLshANRMAAEAQKQVKS 1646
Cdd:pfam05557  520 LKKLEDDLEQVLRLPETTSTM--NFKEVLDLRKELES 554
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 843-1014 2.12e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.06  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  843 AEREKEMASMKEEFTRLKEALEKseaRRKELEEKMVSLLQEKNDLQ-LQVQAEQDNLADAEERCDQLikNKIqleakVKE 921
Cdd:COG3883    61 EALQAEIDKLQAEIAEAEAEIEE---RREELGERARALYRSGGSVSyLDVLLGSESFSDFLDRLSAL--SKI-----ADA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  922 MNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1001
Cdd:COG3883   131 DADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEA 210

                         170
                  ....*....|...
gi 119586555 1002 AHQQALDDLQAEE 1014
Cdd:COG3883   211 AAAAAAAAAAAAA 223
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1056-1301 2.29e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.06  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1056 EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEeleeeleaerTARAKVEKL 1135
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIA----------EAEAEIEER 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1136 RSdlsrELEEISERLEEAGGATSvqiemnkkreaefqkmrrdLEEATLQHEATAAALRKkhADSVAELGEQ----IDNLQ 1211
Cdd:COG3883    85 RE----ELGERARALYRSGGSVS-------------------YLDVLLGSESFSDFLDR--LSALSKIADAdadlLEELK 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1212 RVKQKLEKEKSEfklelddvtsnmeqiIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ 1291
Cdd:COG3883   140 ADKAELEAKKAE---------------LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAE 204

                         250
                  ....*....|
gi 119586555 1292 LDEKEALISQ 1301
Cdd:COG3883   205 LAAAEAAAAA 214
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1341-1553 2.86e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 49.16  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1341 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKH 1420
Cdd:PRK05771   38 EELSNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIK 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1421 RLQNEIEDLM------VDVER----SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS-------QKEARSLSTELF 1483
Cdd:PRK05771  118 ELEQEIERLEpwgnfdLDLSLllgfKYVSVFVGTVPEDKLEELKLESDVENVEYISTDKGYvyvvvvvLKELSDEVEEEL 197

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119586555 1484 KlKNAYEE-SLEHLETFKRENKNLQEEISDLTEQLGSsgkTIHELEKVRKQLEAEKM----ELQSALEEAEASLE 1553
Cdd:PRK05771  198 K-KLGFERlELEEEGTPSELIREIKEELEEIEKERES---LLEELKELAKKYLEELLalyeYLEIELERAEALSK 268
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1084-1331 3.11e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.67  E-value: 3.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1084 DFELNALNARIEDEQALGSQLQKKLKELQARIeeleeeleaertarakveklrSDLSRELEEISERLEEAggatsvqiem 1163
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAEL---------------------EELNEEYNELQAELEAL---------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1164 nkkrEAEFQKMRRDLEEATLQHEATAAALrKKHADSVAELGEQIDNLQRVkqkLEKEksefklELDDVTSNMEQIIKAKA 1243
Cdd:COG3883    64 ----QAEIDKLQAEIAEAEAEIEERREEL-GERARALYRSGGSVSYLDVL---LGSE------SFSDFLDRLSALSKIAD 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1244 ANLEKMcRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1323
Cdd:COG3883   130 ADADLL-EELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAA 208


                  ....*...
gi 119586555 1324 VKAKNALA 1331
Cdd:COG3883   209 EAAAAAAA 216
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 955-1340 3.81e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 49.07  E-value: 3.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   955 DDLELTLAKVEKEKHATENKVKNLTEEMA----GLDEIIAKLTKEKKALQEAH---QQALDDLQAEEDKVN-TLTKAKVK 1026
Cdd:pfam12128  600 EELRERLDKAEEALQSAREKQAAAEEQLVqangELEKASREETFARTALKNARldlRRLFDEKQSEKDKKNkALAERKDS 679

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1027 LEQQVDDLEGSLEQ-EKKVRMDLERAKRKLEGDLKLTQESIMDLENDKqqlderlkkkDFELNALNARIEDEQALGSQLQ 1105
Cdd:pfam12128  680 ANERLNSLEAQLKQlDKKHQAWLEEQKEQKREARTEKQAYWQVVEGAL----------DAQLALLKAAIAARRSGAKAEL 749

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1106 KKLKELQARieeleeeleaERTARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnKKREAEFQKMRRDLEEATLQH 1185
Cdd:pfam12128  750 KALETWYKR----------DLASLGVDPDVIAKLKREIRTLERKIERI-----------AVRRQEVLRYFDWYQETWLQR 808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1186 EataaalrkkhadsvaelgeqiDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAANLeKMCRTLEDQMNEHRSKAE 1265
Cdd:pfam12128  809 R---------------------PRLATQLSNIERAISELQQQLARLIADTKLRRAKLEMER-KASEKQQVRLSENLRGLR 866

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119586555  1266 ETQRSVNDLTSQRAKLQTEnGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEevKAKNALAHALQSARHD 1340
Cdd:pfam12128  867 CEMSKLATLKEDANSEQAQ-GSIGERLAQLEDLKLKRDYLSESVKKYVEHFKNVIAD--HSGSGLAETWESLREE 938
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1313-1888 3.95e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 48.74  E-value: 3.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1313 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELEEA 1390
Cdd:PRK01156  171 LKDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNnlKSALNELSSLEDM 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1391 KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLqNEIEDLMVDVERSNAAAAALDKKQ-RNFDKILAEWK---QKYeesqs 1466
Cdd:PRK01156  251 KNRYESEIKTAESDLSMELEKNNYYKELEERH-MKIINDPVYKNRNYINDYFKYKNDiENKKQILSNIDaeiNKY----- 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1467 elessqKEARSLSTELFKLKNAYEESlehletfKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 1546
Cdd:PRK01156  325 ------HAIIKKLSVLQKDYNDYIKK-------KSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSA 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1547 EAEASLEHEEGKilraQLEFNQIKAEIERKLAEKDEEmeqakrnhlrvVDSLQTSLDAETRSRNEALRVKKKMEG----- 1621
Cdd:PRK01156  392 FISEILKIQEID----PDAIKKELNEINVKLQDISSK-----------VSSLNQRIRALRENLDELSRNMEMLNGqsvcp 456

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1622 ----DLNEMEIqlshaNRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEniaiveRRNNLLQAELEELRAVVEQTE 1697
Cdd:PRK01156  457 vcgtTLGEEKS-----NHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKK------RKEYLESEEINKSINEYNKIE 525

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1698 RSRklAEQELIETSE-RVQLLHSQNTSLINQKKKMD-ADLSQLQTEVEEA--------VQECRNAEEKAKKAITDAAMMA 1767
Cdd:PRK01156  526 SAR--ADLEDIKIKInELKDKHDKYEEIKNRYKSLKlEDLDSKRTSWLNAlavislidIETNRSRSNEIKKQLNDLESRL 603

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1768 EELKKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEqiALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSER 1846
Cdd:PRK01156  604 QEIEIGfPDDKSYIDKSIREIENEANNLNNKYNEIQ--ENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIED 681

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 119586555 1847 RIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEE 1888
Cdd:PRK01156  682 NLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINE 723
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
 1385-1920 4.17e-05

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 48.49  E-value: 4.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1385 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKhrlqNEIEDLMVDVERsnaaaAALDKKQRNFDKILAEWKQKyees 1464
Cdd:pfam05701   42 LELEKVQEEIPEYKKQSEAAEAAKAQVLEELESTK----RLIEELKLNLER-----AQTEEAQAKQDSELAKLRVE---- 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1465 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL----------TEQLGSSGKtihELEKVRKQL 1534
Cdd:pfam05701  109 EMEQGIADEASVAAKAQLEVAKARHAAAVAELKSVKEELESLRKEYASLvserdiaikrAEEAVSASK---EIEKTVEEL 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1535 EAEKMELQSALEEAEAS-LEHEEGKIlRAQLEFNQIKAEIERKLAEKDEEMEQAkRNHLRVVDSLQTSLDAetrsrNEAL 1613
Cdd:pfam05701  186 TIELIATKESLESAHAAhLEAEEHRI-GAALAREQDKLNWEKELKQAEEELQRL-NQQLLSAKDLKSKLET-----ASAL 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1614 RVKKK------MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDdavRANDDLKENIAIVERrnnlLQAELE 1687
Cdd:pfam05701  259 LLDLKaelaayMESKLKEEADGEGNEKKTSTSIQAALASAKKELEEVKANIE---KAKDEVNCLRVAAAS----LRSELE 331

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1688 ELRAVVEQTERSRKLAEqelietservqllhsqntslinqkkkmdADLSQLQTEVEEAVQECRNAEEKAKKAitdAAMMA 1767
Cdd:pfam05701  332 KEKAELASLRQREGMAS----------------------------IAVSSLEAELNRTKSEIALVQAKEKEA---REKMV 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1768 EELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQialkgGKKQLQKLEARVRELENELEA---EQKRNAESVKGMRKS 1844
Cdd:pfam05701  381 ELPKQLQQAAQEAEEAKSLAQAAREELRKAKEEAEQ-----AKAAASTVESRLEAVLKEIEAakaSEKLALAAIKALQES 455

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555  1845 ERRiKELTYQTEEDRKNLLRLQDLvdklqlkvKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK 1920
Cdd:pfam05701  456 ESS-AESTNQEDSPRGVTLSLEEY--------YELSKRAHEAEELANKRVAEAVSQIEEAKESELRSLEKLEEVNR 522
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1536-1921 4.28e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 48.80  E-value: 4.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1536 AEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK-LAEKDEEME-QAKRNHLRVVdslqtsldaetrsrNEAL 1613
Cdd:COG3096   278 NERRELSERALELRRELFGARRQLAEEQYRLVEMARELEELsARESDLEQDyQAASDHLNLV--------------QTAL 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1614 RVKKKME---GDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN----NLLQAeL 1686
Cdd:COG3096   344 RQQEKIEryqEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAiqyqQAVQA-L 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1687 EELRAVVEQTERSRKLAEQELIETSERVQLLHSqntSLINQKKKM-DADLSQLQTE-VEEAVQ------ECRNAEEKAKK 1758
Cdd:COG3096   423 EKARALCGLPDLTPENAEDYLAAFRAKEQQATE---EVLELEQKLsVADAARRQFEkAYELVCkiagevERSQAWQTARE 499

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1759 AITDAAMMAEELKKEQDTSAHLERMKKNMEQtikdlQHRLDE-AEQIALKGGKK--QLQKLEARVRELENELEAEQKRNA 1835
Cdd:COG3096   500 LLRRYRSQQALAQRLQQLRAQLAELEQRLRQ-----QQNAERlLEEFCQRIGQQldAAEELEELLAELEAQLEELEEQAA 574

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1836 ESVKGMRKSERRIKELTYQTEEDRK---NLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD 1912
Cdd:COG3096   575 EAVEQRSELRQQLEQLRARIKELAArapAWLAAQDALERLREQSGEALADSQEVTAAMQQLLEREREATVERDELAARKQ 654


                  ....*....
gi 119586555 1913 IAESQVNKL 1921
Cdd:COG3096   655 ALESQIERL 663
46 PHA02562
endonuclease subunit; Provisional
 931-1221 4.31e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 48.47  E-value: 4.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  931 EMNAELTAKKRkledecsELKRDIDDLELTLAKVEkEKHATENKVKNLTEEMAG--LDEIIAKLTKEKKALQEAHQQald 1008
Cdd:PHA02562  167 EMDKLNKDKIR-------ELNQQIQTLDMKIDHIQ-QQIKTYNKNIEEQRKKNGenIARKQNKYDELVEEAKTIKAE--- 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1009 dlqaeedkVNTLTKAKVKLEQQVDDLEGSLeqeKKVRMDLERAKRKLEgdlKLTQESIMDLEND-----KQQLDERlkkk 1083
Cdd:PHA02562  236 --------IEELTDELLNLVMDIEDPSAAL---NKLNTAAAKIKSKIE---QFQKVIKMYEKGGvcptcTQQISEG---- 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1084 dfelnalNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAggatsvqiem 1163
Cdd:PHA02562  298 -------PDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKA---------- 360

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 119586555 1164 nKKREAEFQKmrrdleeatlqheatAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1221
Cdd:PHA02562  361 -KKVKAAIEE---------------LQAEFVDNAEELAKLQDELDKIVKTKSELVKEK 402
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1497-1852 4.99e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 47.97  E-value: 4.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1497 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQsalEEAEASLEHEEGKILRAQLEFNQIKAEIERK 1576
Cdd:pfam07888   69 EQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELS---EEKDALLAQRAAHEARIRELEEDIKTLTQRV 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1577 LaEKDEEMEQAKRNHLRVVDSLQtsldaETRSRNEALRVK-KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1655
Cdd:pfam07888  146 L-ERETELERMKERAKKAGAQRK-----EEEAERKQLQAKlQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLT 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1656 IQLDDAvranddlkeniaivERRNNLLQAELEELRAVveqtersrklaeQELIETSER-VQLLHSQNTSLINQKKKMDAD 1734
Cdd:pfam07888  220 QKLTTA--------------HRKEAENEALLEELRSL------------QERLNASERkVEGLGEELSSMAAQRDRTQAE 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1735 LSQLQTEVEE----------AVQECRNAEEKAKKAITDAAMMAEElkKEQDTSAHLERMKKNMEQTIKDLQH------RL 1798
Cdd:pfam07888  274 LHQARLQAAQltlqladaslALREGRARWAQERETLQQSAEADKD--RIEKLSAELQRLEERLQEERMEREKlevelgRE 351

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 119586555  1799 DEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT 1852
Cdd:pfam07888  352 KDCNRVQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQRLETVA 405
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
 765-1110 5.13e-05

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 48.40  E-value: 5.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   765 FKAGLLGLLEEMR---------DERLSRIITRIQaqsrgvlaRMEYKK--LLERRDSLlvIQWNIRAFMGVKNWPWMKLY 833
Cdd:pfam15818    5 FKTSLLEALEELRmrreaetqyEEQIGKIIVETQ--------ELKWQKetLQNQKETL--AKQHKEAMAVFKKQLQMKMC 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   834 F----KIKPLLKSAEREKEMASmkeeftrLKEALEKSEARRKELEEKmVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Cdd:pfam15818   75 AleeeKGKYQLATEIKEKEIEG-------LKETLKALQVSKYSLQKK-VSEMEQKLQLHLLAKEDHHKQLNEIEKYYATI 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   910 KNKIQLeakVKEMNERLE----DEEEMNAELTAKKRKLEDECSELKRDIDDL--ELTLAKVE-KEKHATEN--------K 974
Cdd:pfam15818  147 TGQFGL---VKENHGKLEqnvqEAIQLNKRLSALNKKQESEICSLKKELKKVtsDLIKSKVTcQYKMGEENinltikeqK 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   975 VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEgslEQEKKVRMDLERAKRK 1054
Cdd:pfam15818  224 FQELQERLNMELELNKKINEEITHIQEEKQDIIISFQHMQQLLQQQTQANTEMEAELKALK---ENNQTLERDNELQREK 300

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555  1055 LegdlKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Cdd:pfam15818  301 V----KENEEKFLNLQNEHEKALGTWKKHVEELNGEINEIKNELSSLKETHIKLQE 352
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
871-1223 5.35e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 47.59  E-value: 5.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  871 KELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 950
Cdd:COG4372     6 EKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEEL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  951 KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ 1030
Cdd:COG4372    86 NEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Cdd:COG4372   166 LAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELE 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1111 LQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1190
Cdd:COG4372   246 EDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELA 325

                         330       340       350
                  ....*....|....*....|....*....|...
gi 119586555 1191 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Cdd:COG4372   326 KKLELALAILLAELADLLQLLLVGLLDNDVLEL 358
PRK12704 PRK12704
phosphodiesterase; Provisional
 1020-1170 6.03e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 47.85  E-value: 6.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1020 LTKAKVKLEQQVDDLEGSLEQEKK-----VRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI 1094
Cdd:PRK12704   33 IKEAEEEAKRILEEAKKEAEAIKKealleAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKREEEL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1095 EDEQALGSQLQKKLKELQARIEELEEEleaertARAKVEKLrSDLSRE------LEEISERLEEAGGATSVQIEMNKKRE 1168
Cdd:PRK12704  113 EKKEKELEQKQQELEKKEEELEELIEE------QLQELERI-SGLTAEeakeilLEKVEEEARHEAAVLIKEIEEEAKEE 185


                  ..
gi 119586555 1169 AE 1170
Cdd:PRK12704  186 AD 187
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1596-1808 6.31e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1596 DSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1675
Cdd:COG4942    30 EQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAEL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1676 ER------RNNLLQ--------AELEELRAVVEQTERSRKLAEQELIETSERvqlLHSQNTSLINQKKKMDADLSQLQTE 1741
Cdd:COG4942   110 LRalyrlgRQPPLAlllspedfLDAVRRLQYLKYLAPARREQAEELRADLAE---LAALRAELEAERAELEALLAELEEE 186

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555 1742 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1808
Cdd:COG4942   187 RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKG 253
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1423-1923 7.35e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 47.81  E-value: 7.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1423 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAewKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLEtfkRE 1502
Cdd:pfam05557   20 QMELEHKRARIELEKKASALKRQLDRESDRNQE--LQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKL---NE 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1503 NKNLQEEISDLTEQLGSsgktihELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQlEFNQIKAEIERKLAEKDE 1582
Cdd:pfam05557   95 KESQLADAREVISCLKN------ELSELRRQIQRAELELQSTNSELEELQERLDLLKAKAS-EAEQLRQNLEKQQSSLAE 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1583 EMEQAKrnHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMaaeaqkqvKSLQSLLKDTQIQLDDAV 1662
Cdd:pfam05557  168 AEQRIK--ELEFEIQSQEQDSEIVKNSKSELARIPELEKELERLREHNKHLNEN--------IENKLLLKEEVEDLKRKL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1663 RANDDLKENIAIVERRNNLLQAELEELravvEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1742
Cdd:pfam05557  238 EREEKYREEAATLELEKEKLEQELQSW----VKLAQDTGLNLRSPEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKAR 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1743 EEAVQECRNAEEKakkaITDAAMMAEELK--------------KEQD-TSAHLERMKK--NMEQTIKDLQHRLDEAEQIA 1805
Cdd:pfam05557  314 RELEQELAQYLKK----IEDLNKKLKRHKalvrrlqrrvllltKERDgYRAILESYDKelTMSNYSPQLLERIEEAEDMT 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1806 LKGgKKQLQKLEARVRELENELEAEQKRNA--ESVKGMRKSERRIKELTYQTEED---RKNLLRLQDLVDKLQLKVKAYK 1880
Cdd:pfam05557  390 QKM-QAHNEEMEAQLSVAEEELGGYKQQAQtlERELQALRQQESLADPSYSKEEVdslRRKLETLELERQRLREQKNELE 468

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|...
gi 119586555  1881 RQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRA 1923
Cdd:pfam05557  469 MELERRCLQGDYDPKKTKVLHLSMNPAAEAYQQRKNQLEKLQA 511
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1071-1242 8.50e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.07  E-value: 8.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1071 NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Cdd:COG1579     3 PEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1151 EEAGG-----ATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1225
Cdd:COG1579    83 GNVRNnkeyeALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162

                         170
                  ....*....|....*..
gi 119586555 1226 LELDDVTSNMEQIIKAK 1242
Cdd:COG1579   163 AEREELAAKIPPELLAL 179
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1170-1906 8.53e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 48.12  E-value: 8.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1170 EFQKMRRDLEEATLQHEATAAALRKKhadSVAELGEQIDNLQRVKQKLEKEKSE-FKLELDDVTSNMEQIIKAKAANlek 1248
Cdd:TIGR01612  617 EYIKKAIDLKKIIENNNAYIDELAKI---SPYQVPEHLKNKDKIYSTIKSELSKiYEDDIDALYNELSSIVKENAID--- 690

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1249 mcrtledqMNEHRSKAEETQRSVNDLTSQRAKLQTENGE--LSRQLDEKEALISQLTR-GKLTYTQQLEDLKRQLEEEVK 1325
Cdd:TIGR01612  691 --------NTEDKAKLDDLKSKIDKEYDKIQNMETATVElhLSNIENKKNELLDIIVEiKKHIHGEINKDLNKILEDFKN 762

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1326 AKNALAHALQSarhdcdllreqYEEETEAkaelqrvLSKANSEVAQWRTKY-ETDAIQRTEElEEAKkklaQRLQEAEEA 1404
Cdd:TIGR01612  763 KEKELSNKIND-----------YAKEKDE-------LNKYKSKISEIKNHYnDQINIDNIKD-EDAK----QNYDKSKEY 819

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1405 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVER----SNAAAAALDKKQRNFDKILAEWKQKYEESQSEL-ESSQKEARSLS 1479
Cdd:TIGR01612  820 IKTISIKEDEIFKIINEMKFMKDDFLNKVDKfinfENNCKEKIDSEHEQFAELTNKIKAEISDDKLNDyEKKFNDSKSLI 899

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1480 TELfklKNAYEESLEHLETFKREN------KNLQEEISD-------LTEQLGSSGKTIHELEKVRK----QLEAEKMELQ 1542
Cdd:TIGR01612  900 NEI---NKSIEEEYQNINTLKKVDeyikicENTKESIEKfhnkqniLKEILNKNIDTIKESNLIEKsykdKFDNTLIDKI 976

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1543 SALEEA--EASLEHEEGKILRAQLEFNQIKAEI----ERKLAEKDEEMEQAKRNHL-RVVDSLQTSLDAETRSRNEALRV 1615
Cdd:TIGR01612  977 NELDKAfkDASLNDYEAKNNELIKYFNDLKANLgknkENMLYHQFDEKEKATNDIEqKIEDANKNIPNIEIAIHTSIYNI 1056

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1616 KKKMEGD------------LNEMEIQLSHANRMaaEAQKQVKSLQSLLKDTQIQLDDAV-RANDDLK-------ENIAIV 1675
Cdd:TIGR01612 1057 IDEIEKEigkniellnkeiLEEAEINITNFNEI--KEKLKHYNFDDFGKEENIKYADEInKIKDDIKnldqkidHHIKAL 1134

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1676 ERRNNLLQAELEELRAVVEQTER-SRKLAEQELIETSERVQllhsQN-TSLINQKKKMDADLSQLQTEVEE------AVQ 1747
Cdd:TIGR01612 1135 EEIKKKSENYIDEIKAQINDLEDvADKAISNDDPEEIEKKI----ENiVTKIDKKKNIYDEIKKLLNEIAEiekdktSLE 1210

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1748 ECRNAEEKAKKAItdAAMMAEELKKEQDTSAHlerMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENEL 1827
Cdd:TIGR01612 1211 EVKGINLSYGKNL--GKLFLEKIDEEKKKSEH---MIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMETFNISHDD 1285

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1828 EAE----QKRNAESVKGMRKSERRI--------------KEL-TYQTEEDRKN------LLRLQDLVDKLQL-------- 1874
Cdd:TIGR01612 1286 DKDhhiiSKKHDENISDIREKSLKIiedfseesdindikKELqKNLLDAQKHNsdinlyLNEIANIYNILKLnkikkiid 1365

                          810       820       830
                   ....*....|....*....|....*....|..
gi 119586555  1875 KVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1906
Cdd:TIGR01612 1366 EVKEYTKEIEENNKNIKDELDKSEKLIKKIKD 1397
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1703-1890 8.66e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.13  E-value: 8.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1703 AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT-SAHLE 1781
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREElGERAR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1782 RMKKNMEQT-----------IKDLQHRLDEAEQIAlKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1850
Cdd:COG3883    94 ALYRSGGSVsyldvllgsesFSDFLDRLSALSKIA-DADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 119586555 1851 LTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQA 1890
Cdd:COG3883   173 LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAA 212
DUF4686 pfam15742
Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins ...
 839-1083 8.68e-05

Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.


Pssm-ID: 464838 [Multi-domain]  Cd Length: 384  Bit Score: 46.98  E-value: 8.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   839 LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQ---------EKNDLQLQVQAEQDNLADAEERCDQLI 909
Cdd:pfam15742   99 VLKQAQSIKSQNSLQEKLAQEKSRVADAEEKILELQQKLEHAHKvcltdtcilEKKQLEERIKEASENEAKLKQQYQEEQ 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   910 KNKIQLEAKVKEMNERLEDeeemnaeLTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEemagLDEII 989
Cdd:pfam15742  179 QKRKLLDQNVNELQQQVRS-------LQDKEAQLEMTNSQQQLRIQQQEAQLKQLENEKRKSDEHLKSNQE----LSEKL 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   990 AKLTKEKKALQEAHQQALDDLQAEEDKVNtltkakvkleqqvddlegslEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069
Cdd:pfam15742  248 SSLQQEKEALQEELQQVLKQLDVHVRKYN--------------------EKHHHHKAKLRRAKDRLVHEVEQRDERIKQL 307

                          250
                   ....*....|....
gi 119586555  1070 ENDKQQLDERLKKK 1083
Cdd:pfam15742  308 ENEIGILQQQSEKE 321
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 837-1281 9.01e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 47.73  E-value: 9.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQlQVQAEQDNLADAEERCDQLIKNKIQLE 916
Cdd:TIGR00606  703 KLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQ-KVNRDIQRLKNDIEEQETLLGTIMPEE 781

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   917 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELkrDIDDLELTLAKVEKEKHATENKVKNLTEEMagldEIIAKLTKEK 996
Cdd:TIGR00606  782 ESAKVCLTDVTIMERFQMELKDVERKIAQQAAKL--QGSDLDRTVQQVNQEKQEKQHELDTVVSKI----ELNRKLIQDQ 855

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   997 KALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQvddlegSLEQEKKVRMDLERAKRKLEGDLKLTQEsimdLENDKQQL 1076
Cdd:TIGR00606  856 QEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQ------LVELSTEVQSLIREIKDAKEQDSPLETF----LEKDQQEK 925

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERtaRAKVEKLRSDLSrELEEISERLEEAGGA 1156
Cdd:TIGR00606  926 EELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQK--ETELNTVNAQLE-ECEKHQEKINEDMRL 1002

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1157 TSVQIEMNKKREAEFQK--MRRDLEEATLQHEATaaalRKKHADSVAELgeQIDNLQRVKQKLEKE----KSEFKLELDD 1230
Cdd:TIGR00606 1003 MRQDIDTQKIQERWLQDnlTLRKRENELKEVEEE----LKQHLKEMGQM--QVLQMKQEHQKLEENidliKRNHVLALGR 1076

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 119586555  1231 VTSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKL 1281
Cdd:TIGR00606 1077 QKGYEKEIKHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTL 1127
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1494-1923 9.34e-05

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 47.21  E-value: 9.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1494 EHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSAL--------EEAEASLEHEEGKILRAQLE 1565
Cdd:COG5278    76 SFLEPYEEARAEIDELLAELRSLTADNPEQQARLDELEALIDQWLAELEQVIalrragglEAALALVRSGEGKALMDEIR 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1566 FNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK 1645
Cdd:COG5278   156 ARLLLLALALAALLLAAAALLLLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELL 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1646 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1725
Cdd:COG5278   236 AALALALALLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAA 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1726 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1805
Cdd:COG5278   316 AAAAAAAAALAALLALALATALAAAAAALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAI 395

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1806 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEE 1885
Cdd:COG5278   396 AAAAAAAAAEAAAAAAAAAAASAAEALELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAALA 475

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 119586555 1886 AEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRA 1923
Cdd:COG5278   476 ALAAAAAALAEAEAAAALAAAAALSLALALAALLLAAA 513
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 981-1152 9.57e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.07  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  981 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEgSLEQEKKVRMDLERAKRKLEGdlk 1060
Cdd:COG1579    18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE-ARIKKYEEQLGNVRNNKEYEA--- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1061 LTQEsIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIeeleeeleaeRTARAKVEKLRSDLS 1140
Cdd:COG1579    94 LQKE-IESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAEL----------DEELAELEAELEELE 162

                         170
                  ....*....|..
gi 119586555 1141 RELEEISERLEE 1152
Cdd:COG1579   163 AEREELAAKIPP 174
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1478-1657 1.21e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.93  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1478 LSTELFKLKNAYEESLEHLETFKRENKnlqeeISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1557
Cdd:COG3206   180 LEEQLPELRKELEEAEAALEEFRQKNG-----LVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPD 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1558 KI--LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVV------DSLQTSLDAET--------------RSRNEALR- 1614
Cdd:COG3206   255 ALpeLLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIalraqiAALRAQLQQEAqrilasleaelealQAREASLQa 334

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 119586555 1615 ----VKKKMEgDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1657
Cdd:COG3206   335 qlaqLEARLA-ELPELEAELRRLEREVEVARELYESLLQRLEEARLA 380
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
859-995 1.21e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 47.16  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  859 LKEALEKSEARRKELEEKmvsllqeknDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTA 938
Cdd:COG2433   378 IEEALEELIEKELPEEEP---------EAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLER 448

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119586555  939 KKRKL----------EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLtEEMAGLDE--------IIAKLTKE 995
Cdd:COG2433   449 ELSEArseerreirkDREISRLDREIERLERELEEERERIEELKRKLERL-KELWKLEHsgelvpvkVVEKFTKE 522
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1375-1889 1.21e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 47.27  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1375 KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRnfdkiL 1454
Cdd:TIGR00618  177 QYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKRE-----A 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1455 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEES------LEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE 1528
Cdd:TIGR00618  252 QEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRArkaaplAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRA 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1529 KVRKQ---LEAEKMELQSAL-EEAEASLEHEEGKILRAQLEfnQIKAEIERKLA-----EKDEEMEQAKRNHLRVVDSLQ 1599
Cdd:TIGR00618  332 AHVKQqssIEEQRRLLQTLHsQEIHIRDAHEVATSIREISC--QQHTLTQHIHTlqqqkTTLTQKLQSLCKELDILQREQ 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1600 TSLDAETRSRNEALRVKKKMEGdlnEMEIQLSHANRMAAEAQKQVKSLqsllKDTQIQLDDAVRANDDLKENIAIVErrn 1679
Cdd:TIGR00618  410 ATIDTRTSAFRDLQGQLAHAKK---QQELQQRYAELCAAAITCTAQCE----KLEKIHLQESAQSLKEREQQLQTKE--- 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1680 NLLQAELE----ELRAVVEQTERSRKLAEQELIETSERVQLLHSQ-NTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1754
Cdd:TIGR00618  480 QIHLQETRkkavVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGpLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRA 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1755 KAKKAITDAamMAEELKKEQDTSAHLERMKK--NMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQK 1832
Cdd:TIGR00618  560 SLKEQMQEI--QQSFSILTQCDNRSKEDIPNlqNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQC 637

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555  1833 RNAESVKGMRKsERRIKELTYQTEEDRKNLLRLQDlvdklqlKVKAYKRQAEEAEEQ 1889
Cdd:TIGR00618  638 SQELALKLTAL-HALQLTLTQERVREHALSIRVLP-------KELLASRQLALQKMQ 686
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 911-1180 1.32e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.04  E-value: 1.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   911 NKIQLEAKVKEM-NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDeiI 989
Cdd:pfam17380  285 SERQQQEKFEKMeQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRE--L 362

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   990 AKLTKEKKALQEAHQQALDDLQAEEDKVN--------TLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAK----RKLEG 1057
Cdd:pfam17380  363 ERIRQEEIAMEISRMRELERLQMERQQKNervrqeleAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARqrevRRLEE 442

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1058 DLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQalgsQLQKKLKELQARIEELEEEleAERTARAKVEKLRS 1137
Cdd:pfam17380  443 ERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEK----RDRKRAEEQRRKILEKELE--ERKQAMIEEERKRK 516

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 119586555  1138 DLSRELEEIS------ERLEEAGGATSVQIEMNKKREAEfQKMRRDLEE 1180
Cdd:pfam17380  517 LLEKEMEERQkaiyeeERRREAEEERRKQQEMEERRRIQ-EQMRKATEE 564
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 873-1111 1.42e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 46.84  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  873 LEEKMVSLLQEKNDLQLqVQAEQDNLADAEERcdqlIKNKIQLEAKVKEMNERLEDEeeMNAELTAKKRKLEDECSELKR 952
Cdd:PRK05771   14 LKSYKDEVLEALHELGV-VHIEDLKEELSNER----LRKLRSLLTKLSEALDKLRSY--LPKLNPLREEKKKVSVKSLEE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  953 DIDDLELTLAKVEKEkhatenkVKNLTEEMAGLDEIIAKLTKEKKALQ--EAHQQALDDLQAEED---KVNTLTKAKVKL 1027
Cdd:PRK05771   87 LIKDVEEELEKIEKE-------IKELEEEISELENEIKELEQEIERLEpwGNFDLDLSLLLGFKYvsvFVGTVPEDKLEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1028 EQQVDDLEGSLEQEKK------VRMDLERAKRKLEGDLKLTQESIMDLENDKqQLDERLKKKDFELNALNARIEDeqalg 1101
Cdd:PRK05771  160 LKLESDVENVEYISTDkgyvyvVVVVLKELSDEVEEELKKLGFERLELEEEG-TPSELIREIKEELEEIEKERES----- 233

                         250
                  ....*....|
gi 119586555 1102 sqLQKKLKEL 1111
Cdd:PRK05771  234 --LLEELKEL 241
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1535-1764 1.43e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.36  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1535 EAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQakrnhlrvVDSLQTSLDaetrsrnealr 1614
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAE--------IDKLQAEIA----------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1615 vkkKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIqlDDAVRANDDLKeniAIVERRNNLLQaELEELRAVVE 1694
Cdd:COG3883    76 ---EAEAEIEERREELGERARALYRSGGSVSYLDVLLGSESF--SDFLDRLSALS---KIADADADLLE-ELKADKAELE 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1695 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAA 1764
Cdd:COG3883   147 AKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAA 216
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1379-1924 1.48e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1379 DAIQRTEELEEAKKKLaqrlqeaEEAVEAVNAKCSSLEKTKHRLQNEIEDlmvdVERSNAAAAALDKKQRNFDKILAEWK 1458
Cdd:PRK01156  156 DEILEINSLERNYDKL-------KDVIDMLRAEISNIDYLEEKLKSSNLE----LENIKKQIADDEKSHSITLKEIERLS 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1459 QKYEESQSELESSQKEARSLSTeLFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG--------SSGKTIHELEKV 1530
Cdd:PRK01156  225 IEYNNAMDDYNNLKSALNELSS-LEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMkiindpvyKNRNYINDYFKY 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1531 RKQLEAEKMELQSAleEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRN 1610
Cdd:PRK01156  304 KNDIENKKQILSNI--DAEINKYHAIIKKLSVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEE 381

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1611 EALRVKK---KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN-------- 1679
Cdd:PRK01156  382 YSKNIERmsaFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSvcpvcgtt 461

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1680 ----------NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS-LINQKKKMDADLSQLqTEVEEAVQE 1748
Cdd:PRK01156  462 lgeeksnhiiNHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINkSINEYNKIESARADL-EDIKIKINE 540

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1749 CRNAEEKAKKAITDAAMMAEELKKEQDTSaHLERMKKNMEQTIKDLQHRLDEAeqialkggKKQLQKLEARVRELENELE 1828
Cdd:PRK01156  541 LKDKHDKYEEIKNRYKSLKLEDLDSKRTS-WLNALAVISLIDIETNRSRSNEI--------KKQLNDLESRLQEIEIGFP 611

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1829 AEQKRNAESVkgmrkseRRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQA---EEAEEQANTNLSKFRKVQHELD 1905
Cdd:PRK01156  612 DDKSYIDKSI-------REIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIaeiDSIIPDLKEITSRINDIEDNLK 684

                         570
                  ....*....|....*....
gi 119586555 1906 EAEERADIAESQVNKLRAK 1924
Cdd:PRK01156  685 KSRKALDDAKANRARLEST 703
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1090-1365 1.60e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.55  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1090 LNARIEDEQALGSQLQKKLKELQARIeeleeeleaeRTARAKVEKLRS-----DLSRELEEISERLEEAggatsvqiemn 1164
Cdd:COG3206   166 LELRREEARKALEFLEEQLPELRKEL----------EEAEAALEEFRQknglvDLSEEAKLLLQQLSEL----------- 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1165 kkrEAEFQKMRRDLEEAtlqhEATAAALRKKHADSVAELGEQIDN--LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAK 1242
Cdd:COG3206   225 ---ESQLAEARAELAEA----EARLAALRAQLGSGPDALPELLQSpvIQQLRAQLAELEAELAELSARYTPNHPDVIALR 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1243 A--ANLEkmcrtledqmnehRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRgkltYTQQLEDLKRQL 1320
Cdd:COG3206   298 AqiAALR-------------AQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPE----LEAELRRLEREV 360

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 119586555 1321 EeevkaknalahalqsarhdcdLLREQYE------EETEAKAELQ----RVLSKA 1365
Cdd:COG3206   361 E---------------------VARELYEsllqrlEEARLAEALTvgnvRVIDPA 394
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1322-1624 1.71e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 46.99  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1322 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAE--LQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLaQRLQ 1399
Cdd:COG5022   810 KEYRSYLACIIKLQKTIKREKKLRETEEVEFSLKAEvlIQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERQL-QELK 888

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1400 EAEEAVEAVNAKCSSLEKTKHRLQNEIE-DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKeaRSL 1478
Cdd:COG5022   889 IDVKSISSLKLVNLELESEIIELKKSLSsDLIENLEFKTELIARLKKLLNNIDLEEGPSIEYVKLPELNKLHEVE--SKL 966

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1479 STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGkTIHELEKVRKQLEAEKMELQSAleEAEASLEHEEGK 1558
Cdd:COG5022   967 KETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYG-ALQESTKQLKELPVEVAELQSA--SKIISSESTELS 1043

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119586555 1559 ILR--AQLEFNQIKAeiERKLAEKDEEMEQAKRNHLRvvDSLQTSLDAETRSRNEALRVKKKMEGDLN 1624
Cdd:COG5022  1044 ILKplQKLKGLLLLE--NNQLQARYKALKLRRENSLL--DDKQLYQLESTENLLKTINVKDLEVTNRN 1107
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 777-1261 1.81e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 46.58  E-value: 1.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   777 RDERLSRIITRIQAQSRGVLARMEYKKLLER------------RDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAE 844
Cdd:TIGR00606  547 KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDwlhskskeinqtRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYED 626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   845 REKEMASMKEEFTRLKEALEKSEARRKELeekmvSLLQEKNDLQLQVQAEqdnLADAEERCDQLIKNKIQLEakvKEMNE 924
Cdd:TIGR00606  627 KLFDVCGSQDEESDLERLKEEIEKSSKQR-----AMLAGATAVYSQFITQ---LTDENQSCCPVCQRVFQTE---AELQE 695

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   925 RLEDEEEMNAELTAKKRKLEDECSELKRDIDDL-------ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
Cdd:TIGR00606  696 FISDLQSKLRLAPDKLKSTESELKKKEKRRDEMlglapgrQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLG 775

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   998 AL---QEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEG-----SLEQEKKVRMDLERAKRKLEGDLKLTQESImdl 1069
Cdd:TIGR00606  776 TImpeEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGsdldrTVQQVNQEKQEKQHELDTVVSKIELNRKLI--- 852

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1070 eNDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1149
Cdd:TIGR00606  853 -QDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISS 931

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1150 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATlqhEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD 1229
Cdd:TIGR00606  932 KETSNKKAQDKVNDIKEKVKNIHGYMKDIENKI---QDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDID 1008

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 119586555  1230 dvTSNMEQ----------IIKAKAANLEKMCRTLEDQMNEHR 1261
Cdd:TIGR00606 1009 --TQKIQErwlqdnltlrKRENELKEVEEELKQHLKEMGQMQ 1048
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 843-1086 1.82e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.43  E-value: 1.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEM 922
Cdd:pfam07888   76 RELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERM 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   923 NER-------LEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAK---L 992
Cdd:pfam07888  156 KERakkagaqRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAEneaL 235

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   993 TKEKKALQE---AHQQA-------LDDLQAEEDKVNT-LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL 1061
Cdd:pfam07888  236 LEELRSLQErlnASERKveglgeeLSSMAAQRDRTQAeLHQARLQAAQLTLQLADASLALREGRARWAQERETLQQSAEA 315

                          250       260
                   ....*....|....*....|....*
gi 119586555  1062 TQESIMDLENDKQQLDERLKKKDFE 1086
Cdd:pfam07888  316 DKDRIEKLSAELQRLEERLQEERME 340
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 843-967 1.89e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKM--VSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920
Cdd:COG1579    48 EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLgnVRNNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELA 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 119586555  921 EMNERLEDEEEmnaELTAKKRKLEDECSELKRDIDDLELTLAKVEKE 967
Cdd:COG1579   128 ELEAELAELEA---ELEEKKAELDEELAELEAELEELEAEREELAAK 171
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1235-1448 1.94e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.55  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1235 MEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQR--AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ 1312
Cdd:COG3206   162 LEQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNglVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1313 LEDLKRQLEEEVKAKNALAH---------ALQSARHDCDLLREQYEEE----TEAKAELQRVLSKANSEVAQWRTKYETD 1379
Cdd:COG3206   242 LAALRAQLGSGPDALPELLQspviqqlraQLAELEAELAELSARYTPNhpdvIALRAQIAALRAQLQQEAQRILASLEAE 321

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119586555 1380 AiqrtEELEEAKKKLAQRLQEAEEAVEAVNAKcsslektkhrlQNEIEDLMVDVERSNAAAAALDKKQR 1448
Cdd:COG3206   322 L----EALQAREASLQAQLAQLEARLAELPEL-----------EAELRRLEREVEVARELYESLLQRLE 375
Yuri_gagarin pfam15934
Yuri gagarin; The yuri gagarin protein found in Drosophila, it plays roles in spermatogenesis.
 868-1022 1.98e-04

Yuri gagarin; The yuri gagarin protein found in Drosophila, it plays roles in spermatogenesis.


Pssm-ID: 318204 [Multi-domain]  Cd Length: 234  Bit Score: 44.95  E-value: 1.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   868 ARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQL---------------IKNKI--------QLEAKVKEMNE 924
Cdd:pfam15934   41 ENKNEQEQQLKEFTVQNQRLACQIDNLHETLKDRDHQIKQLqsmitgysdisennrLKEEIhdlkqkncVQARVVRKMGL 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   925 RLEDEEEMNAELTAKKRKL----EDECSELK---RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLdeiiakltKEKK 997
Cdd:pfam15934  121 ELKGQEEQRVELCDKYESLlgsfEEQCQELKranRRVQSLQTRLSQVEKLQEELRTERKILREEVIAL--------KEKD 192

                          170       180
                   ....*....|....*....|....*....
gi 119586555   998 ALQEAHQQALDD----LQAEEDKVNTLTK 1022
Cdd:pfam15934  193 AKSNGRERALQDqlkcCQTEIEKSRTLIR 221
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 859-1085 2.13e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 46.30  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   859 LKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDnladaEERCDQLIKNKIQLEAKVKEMNERLEdeeemnaeltA 938
Cdd:pfam18971  619 LEKSLRKREHLEKEVEKKLESKSGNKNKMEAKAQANSQ-----KDEIFALINKEANRDARAIAYTQNLK----------G 683

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   939 KKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAkLTKEKKALQEAHQQALDDLQAEEDK-V 1017
Cdd:pfam18971  684 IKRELSDKLEKISKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLG-INPEWISKVENLNAALNEFKNGKNKdF 762

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555  1018 NTLTKAKVKLEQQVDDLEGSLEQEKKV-RMDLERAKRKLEGDLKLTQESIMDLEN-DKQQLDERLKK-KDF 1085
Cdd:pfam18971  763 SKVTQAKSDLENSVKDVIINQKVTDKVdNLNQAVSVAKAMGDFSRVEQVLADLKNfSKEQLAQQAQKnEDF 833
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1490-1629 2.16e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 46.39  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1490 EESLEHLeTFKRENKNLQEEISDLTEQ---LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF 1566
Cdd:COG2433   379 EEALEEL-IEKELPEEEPEAEREKEHEereLTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEE 457

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119586555 1567 NQiKAEIERKLAEKDEEmeqakrnhlrvVDSLQTSLDaETRSRNEALRVKKKMEGDLNEMEIQ 1629
Cdd:COG2433   458 RR-EIRKDREISRLDRE-----------IERLERELE-EERERIEELKRKLERLKELWKLEHS 507
PRK12704 PRK12704
phosphodiesterase; Provisional
 1326-1460 2.21e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.92  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1326 AKNALAHALQSARHDCDLLREqyEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAV 1405
Cdd:PRK12704   25 RKKIAEAKIKEAEEEAKRILE--EAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKL 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 119586555 1406 EAVNAKCSSLEKTKHRLQNEIEDlmvdversnaaaaaLDKKQRNFDKILAEWKQK 1460
Cdd:PRK12704  103 ELLEKREEELEKKEKELEQKQQE--------------LEKKEEELEELIEEQLQE 143
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1254-1447 2.29e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1254 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1333
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1334 LQSARHDCDLL---------------REQYEEETEAKAELQRVLSKANSEVAQwrtkYETDAIQRTEELEEAKKKLAQRL 1398
Cdd:COG3883    95 LYRSGGSVSYLdvllgsesfsdfldrLSALSKIADADADLLEELKADKAELEA----KKAELEAKLAELEALKAELEAAK 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 119586555 1399 QEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1447
Cdd:COG3883   171 AELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAA 219
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1670-1918 2.51e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.53  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1670 ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEC 1749
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1750 RNAEEKAKKAITDAAMMAE----ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE--AEQIALKGGKKQLQKLEARVREL 1823
Cdd:COG4942   100 EAQKEELAELLRALYRLGRqpplALLLSPEDFLDAVRRLQYLKYLAPARREQAEElrADLAELAALRAELEAERAELEAL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1824 ENELEAEQKRnaesvkgmrkserrikeltyqteedrknllrLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHE 1903
Cdd:COG4942   180 LAELEEERAA-------------------------------LEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228

                         250
                  ....*....|....*
gi 119586555 1904 LDEAEERADIAESQV 1918
Cdd:COG4942   229 IARLEAEAAAAAERT 243
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1048-1587 3.14e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.05  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1048 LERAKRKLEGDLKLTQESIMDLENdkqqLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT 1127
Cdd:PRK01156  164 LERNYDKLKDVIDMLRAEISNIDY----LEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKS 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1128 A--------------RAKVEKLRSDLSRELEE---ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1190
Cdd:PRK01156  240 AlnelssledmknryESEIKTAESDLSMELEKnnyYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDA 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1191 ALRKKHAD--SVAELG---EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI--IKAKAANLEKMCRTLEDQMNEHRSK 1263
Cdd:PRK01156  320 EINKYHAIikKLSVLQkdyNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIesLKKKIEEYSKNIERMSAFISEILKI 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1264 AEETQRSVNdltsqraklqTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE---------------EEVKAKN 1328
Cdd:PRK01156  400 QEIDPDAIK----------KELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEmlngqsvcpvcgttlGEEKSNH 469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1329 ALAH---ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAqRLQEAEEAV 1405
Cdd:PRK01156  470 IINHyneKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKIN-ELKDKHDKY 548

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1406 EAVNAKCSSLEKTKHRLQNEiEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1485
Cdd:PRK01156  549 EEIKNRYKSLKLEDLDSKRT-SWLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENE 627

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1486 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL---EAEKMELQSALEEAEASLEHEEG--KIL 1560
Cdd:PRK01156  628 ANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRIndiEDNLKKSRKALDDAKANRARLEStiEIL 707

                         570       580
                  ....*....|....*....|....*...
gi 119586555 1561 RAQL-EFNQIKAEIERKLaEKDEEMEQA 1587
Cdd:PRK01156  708 RTRInELSDRINDINETL-ESMKKIKKA 734
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1674-1812 3.73e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.59  E-value: 3.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1674 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDAdlsQLQTEVEEAVQECRNAE 1753
Cdd:PRK00409  503 IIEEAKKLIGEDKEKLNELIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQE---EEDKLLEEAEKEAQQAI 579

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 119586555 1754 EKAKKAITDAAMMAEELKKEQDTSAHLermkKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1812
Cdd:PRK00409  580 KEAKKEADEIIKELRQLQKGGYASVKA----HELIEARKRLNKANEKKEKKKKKQKEKQ 634
PRK11637 PRK11637
AmiB activator; Provisional
 885-1097 3.86e-04

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 45.07  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  885 NDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKemnerleDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKV 964
Cdd:PRK11637   43 SDNRDQLKSIQQDIAAKEKSVRQQQQQRASLLAQLK-------KQEEAISQASRKLRETQNTLNQLNKQIDELNASIAKL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  965 EKEKHATEnkvKNLTEEM---------AGLDEIIAKLTKEKKALQEAHQQALDdlQAEEDKVNTLTKAKVKLEQQVDDLE 1035
Cdd:PRK11637  116 EQQQAAQE---RLLAAQLdaafrqgehTGLQLILSGEESQRGERILAYFGYLN--QARQETIAELKQTREELAAQKAELE 190

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN----DKQQLDErLKKKDFELNALNARIEDE 1097
Cdd:PRK11637  191 EKQSQQKTLLYEQQAQQQKLEQARNERKKTLTGLESslqkDQQQLSE-LRANESRLRDSIARAERE 255
PRK12704 PRK12704
phosphodiesterase; Provisional
 898-1013 3.93e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.15  E-value: 3.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  898 LADAEERCDQLIKN----------KIQLEAKVKEMNERLEDEEE---MNAELTAKKRKLEDECSELKRDIDDLELTLAKV 964
Cdd:PRK12704   33 IKEAEEEAKRILEEakkeaeaikkEALLEAKEEIHKLRNEFEKElreRRNELQKLEKRLLQKEENLDRKLELLEKREEEL 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 119586555  965 EKEKHATENKVKNLTEEMAGLDEIIAK----------LTKEkkalqEAHQQALDDLQAE 1013
Cdd:PRK12704  113 EKKEKELEQKQQELEKKEEELEELIEEqlqelerisgLTAE-----EAKEILLEKVEEE 166
PRK12704 PRK12704
phosphodiesterase; Provisional
 834-998 4.06e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.15  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  834 FKIKPLLKSAEREKEMAS------MKEEFTRLKEALEK-SEARRKELEEKMVSLLQEKNDLqlqvqaeqdnladaEERCD 906
Cdd:PRK12704   38 EEAKRILEEAKKEAEAIKkealleAKEEIHKLRNEFEKeLRERRNELQKLEKRLLQKEENL--------------DRKLE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  907 QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE---CSELKRDiDDLELTLAKVEKE-KHATENKVKNLTEEm 982
Cdd:PRK12704  104 LLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQElerISGLTAE-EAKEILLEKVEEEaRHEAAVLIKEIEEE- 181

                         170
                  ....*....|....*.
gi 119586555  983 agldeiiAKLTKEKKA 998
Cdd:PRK12704  182 -------AKEEADKKA 190
46 PHA02562
endonuclease subunit; Provisional
 1688-1872 4.39e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 45.01  E-value: 4.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1688 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKK---AITDAA 1764
Cdd:PHA02562  189 KIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKlntAAAKIK 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1765 MMAEELKKE--------------QDTSAHLERMKKNMEQtIKDLQHRLDEAE--QIALKGGKKQLQKLEARVRELENELE 1828
Cdd:PHA02562  269 SKIEQFQKVikmyekggvcptctQQISEGPDRITKIKDK-LKELQHSLEKLDtaIDELEEIMDEFNEQSKKLLELKNKIS 347

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 119586555 1829 AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKL 1872
Cdd:PHA02562  348 TNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKI 391
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 1141-1411 4.55e-04

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 45.32  E-value: 4.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1141 RELEEISERLEEAggatsvqiemnKKR-EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELgeqidnLQRVKQKLEK 1219
Cdd:PRK05035  439 RAIEQEKKKAEEA-----------KARfEARQARLEREKAAREARHKKAAEARAAKDKDAVAAA------LARVKAKKAA 501

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1220 EKSEFKLELDDVTSNMEQIIKAKAANLEKmcrtledqmnehRSKAEETQRSVNDltsqraklqtengelsrqlDEKEALI 1299
Cdd:PRK05035  502 ATQPIVIKAGARPDNSAVIAAREARKAQA------------RARQAEKQAAAAA-------------------DPKKAAV 550

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1300 SQ-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALqsARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET 1378
Cdd:PRK05035  551 AAaIARAKAKKAAQQAANAEAEEEVDPKKAAVAAAI--ARAKAKKAAQQAASAEPEEQVAEVDPKKAAVAAAIARAKAKK 628

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 119586555 1379 DAIQRTEELEE---------------AKKKLAQRLQEAEEAVEAVNAK 1411
Cdd:PRK05035  629 AEQQANAEPEEpvdprkaavaaaiarAKARKAAQQQANAEPEEAEDPK 676
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 960-1191 4.73e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.82  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  960 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLE 1039
Cdd:COG3883    10 TPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1040 qekkvrmdlERAKRKLEG-------DLKLTQESIMDL-----------ENDKQQLDERLKKKDfELNALNARIEDEQAlg 1101
Cdd:COG3883    90 ---------ERARALYRSggsvsylDVLLGSESFSDFldrlsalskiaDADADLLEELKADKA-ELEAKKAELEAKLA-- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1102 sQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA 1181
Cdd:COG3883   158 -ELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAA 236

                         250
                  ....*....|
gi 119586555 1182 TLQHEATAAA 1191
Cdd:COG3883   237 AAAAAAAASA 246
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 1629-1834 5.29e-04

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 43.86  E-value: 5.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1629 QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDdavRANDDLKENiaiverrnnllQAELEELRAVVEQTERSRKLAEQELI 1708
Cdd:pfam00261   23 KLEEAEKRAEKAEAEVAALNRRIQLLEEELE---RTEERLAEA-----------LEKLEEAEKAADESERGRKVLENRAL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1709 ETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE------- 1781
Cdd:pfam00261   89 KDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSLEaseekas 168

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 119586555  1782 RMKKNMEQTIKDLQHRLDEAEQIALKGgKKQLQKLEARVRELENELEAEQKRN 1834
Cdd:pfam00261  169 EREDKYEEQIRFLTEKLKEAETRAEFA-ERSVQKLEKEVDRLEDELEAEKEKY 220
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
850-1173 5.77e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.51  E-value: 5.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  850 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDE 929
Cdd:COG4372    27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  930 EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH-QQALD 1008
Cdd:COG4372   107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEaEQALD 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELN 1088
Cdd:COG4372   187 ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELA 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1089 ALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1168
Cdd:COG4372   267 ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLL 346


                  ....*
gi 119586555 1169 AEFQK 1173
Cdd:COG4372   347 LVGLL 351
Filament pfam00038
Intermediate filament protein;
873-1151 6.02e-04

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 44.14  E-value: 6.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   873 LEEKMVSLLQEKNDLQLQVQAEQDN--------LADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE 944
Cdd:pfam00038   23 LEQQNKLLETKISELRQKKGAEPSRlyslyekeIEDLRRQLDTLTVERARLQLELDNLRLAAEDFRQKYEDELNLRTSAE 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   945 DECSELKRDIDdlELTLAKVEkekhaTENKVKNLTEEMAGLDEIiakLTKEKKALQEAHQQalDDLQAEEDKVNT--LTK 1022
Cdd:pfam00038  103 NDLVGLRKDLD--EATLARVD-----LEAKIESLKEELAFLKKN---HEEEVRELQAQVSD--TQVNVEMDAARKldLTS 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1023 AKVKLEQQVDdlegslEQEKKVRMDLERA-KRKLEgdlKLTQESIMDLEnDKQQLDERLKKKDFELNALNARIEDEQALG 1101
Cdd:pfam00038  171 ALAEIRAQYE------EIAAKNREEAEEWyQSKLE---ELQQAAARNGD-ALRSAKEEITELRRTIQSLEIELQSLKKQK 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 119586555  1102 SQLQKKLKELQARIEEleeeleaertARAKVEKLRSDLSRELEEISERLE 1151
Cdd:pfam00038  241 ASLERQLAETEERYEL----------QLADYQELISELEAELQETRQEMA 280
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 830-1322 6.10e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 44.73  E-value: 6.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   830 MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEkndLQLQVQ----------------- 892
Cdd:pfam05557  125 LELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSLAEAEQRIKELEFE---IQSQEQdseivknskselaripe 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   893 --AEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTA---KKRKLEDECSELKRDIDDLELTLAKVEke 967
Cdd:pfam05557  202 leKELERLREHNKHLNENIENKLLLKEEVEDLKRKLEREEKYREEAATlelEKEKLEQELQSWVKLAQDTGLNLRSPE-- 279

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   968 khATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQalddlqaeedkvntltkakvkLEQQVDDLEGSLEQEKKVRMD 1047
Cdd:pfam05557  280 --DLSRRIEQLQQREIVLKEENSSLTSSARQLEKARRE---------------------LEQELAQYLKKIEDLNKKLKR 336

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1048 LERAKRKLegdlkltQESIMDLENDKQQLDERLKKKDFELNALNAriedeqalGSQLQKKLKELqarieeleeeleaert 1127
Cdd:pfam05557  337 HKALVRRL-------QRRVLLLTKERDGYRAILESYDKELTMSNY--------SPQLLERIEEA---------------- 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1128 arakvEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDleeatlqheaTAAALRKKHADSVAELGEQI 1207
Cdd:pfam05557  386 -----EDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQ----------ESLADPSYSKEEVDSLRRKL 450

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1208 DNLQRVKQKLEKEKSEFKLELddVTSNMEQIIKAKAanlekmCRTLEDQMNehrSKAEETQRSVNDLTsqraKLQTENGE 1287
Cdd:pfam05557  451 ETLELERQRLREQKNELEMEL--ERRCLQGDYDPKK------TKVLHLSMN---PAAEAYQQRKNQLE----KLQAEIER 515

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 119586555  1288 LSRQL----DEKEALISQLTRGKLTYTQQLEDLKRQLEE 1322
Cdd:pfam05557  516 LKRLLkkleDDLEQVLRLPETTSTMNFKEVLDLRKELES 554
PLN02939 PLN02939
transferase, transferring glycosyl groups
 1573-1927 7.51e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 44.51  E-value: 7.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1573 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAlrvkkKMEGDLNEMEIQLSHANRMAAEAQK---QVKSLQS 1649
Cdd:PLN02939   61 SNSKLQSNTDENGQLENTSLRTVMELPQKSTSSDDDHNRA-----SMQRDEAIAAIDNEQQTNSKDGEQLsdfQLEDLVG 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1650 LLKDTQ---IQLDDA-VRANDDLKEniaiVERRNNLLQAELEELRAVVEQTERSRKLAEQELIetseRVQLLHSQntsLI 1725
Cdd:PLN02939  136 MIQNAEkniLLLNQArLQALEDLEK----ILTEKEALQGKINILEMRLSETDARIKLAAQEKI----HVEILEEQ---LE 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1726 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS---AHLERMKKNMEQTIKDLQHRLDEAE 1802
Cdd:PLN02939  205 KLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAETEervFKLEKERSLLDASLRELESKFIVAQ 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1803 QIALKGGKKQLQKLEARVRELENELEAEQKRNAESV---KGMRKSERRIKELTYQTEEDRKNLLRLQdLVDKLQLKVKAY 1879
Cdd:PLN02939  285 EDVSKLSPLQYDCWWEKVENLQDLLDRATNQVEKAAlvlDQNQDLRDKVDKLEASLKEANVSKFSSY-KVELLQQKLKLL 363

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 119586555 1880 KRQAEEAEEQANTnlskfrKVQHELDEAEERADIAESQVNKLRAKSRD 1927
Cdd:PLN02939  364 EERLQASDHEIHS------YIQLYQESIKEFQDTLSKLKEESKKRSLE 405
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1476-1911 7.64e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.57  E-value: 7.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1476 RSLSTELFKLKNAYEESLEHLEtfkrenKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1555
Cdd:TIGR00618  179 TQLALMEFAKKKSLHGKAELLT------LRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQ 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1556 EGKiLRAQLEFNQIKAEIERKLA-EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEiQLSHAN 1634
Cdd:TIGR00618  253 EEQ-LKKQQLLKQLRARIEELRAqEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRA-KLLMKR 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1635 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQ----------AELEELRAVVEQTERSRKLAE 1704
Cdd:TIGR00618  331 AAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQhihtlqqqktTLTQKLQSLCKELDILQREQA 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1705 QELIETSE----RVQLLHSQNTSLINQKKKMD-----ADLSQLQTEVEEAVQECRNA-EEKAKKAITDAAMMAEELKKEQ 1774
Cdd:TIGR00618  411 TIDTRTSAfrdlQGQLAHAKKQQELQQRYAELcaaaiTCTAQCEKLEKIHLQESAQSlKEREQQLQTKEQIHLQETRKKA 490

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1775 DTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGG-----------KKQLQKLEARVRELENELEAEQKRNAESVKGMRK 1843
Cdd:TIGR00618  491 VVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPltrrmqrgeqtYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQ 570

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119586555  1844 SERRIKELTYQTEEDRKNLL----RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1911
Cdd:TIGR00618  571 SFSILTQCDNRSKEDIPNLQnitvRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELA 642
PTZ00121 PTZ00121
MAEBL; Provisional
 800-1064 7.90e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 7.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  800 EYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKeeftrlKEALEKSEARRKELEEKMVS 879
Cdd:PTZ00121 1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIK------AEELKKAEEEKKKVEQLKKK 1641

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  880 LLQEKNDLQLQVQAEQDNLADAEErcdqlIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRdiddlel 959
Cdd:PTZ00121 1642 EAEEKKKAEELKKAEEENKIKAAE-----EAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKK------- 1709

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  960 tlaKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQalddlQAEEDKVNTLTKAKVKLEQQVDDL----- 1034
Cdd:PTZ00121 1710 ---KEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKD-----EEEKKKIAHLKKEEEKKAEEIRKEkeavi 1781

                         250       260       270
                  ....*....|....*....|....*....|.
gi 119586555 1035 -EGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Cdd:PTZ00121 1782 eEELDEEDEKRRMEVDKKIKDIFDNFANIIE 1812
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 853-1407 8.10e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 44.66  E-value: 8.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   853 KEEFTRLKEALEKSEARRKELEEKM---VSLLQE-KNDLQLQVQAEQDNLADAEERCDQLIKNK--IQLEAKVKEMNERL 926
Cdd:TIGR01612 1103 KEENIKYADEINKIKDDIKNLDQKIdhhIKALEEiKKKSENYIDEIKAQINDLEDVADKAISNDdpEEIEKKIENIVTKI 1182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   927 EDEEEMNAELtakkRKLEDECSELKRDIDDLE---------------LTLAKVEKEKHATENKVKNLTEEMAGLDEIiak 991
Cdd:TIGR01612 1183 DKKKNIYDEI----KKLLNEIAEIEKDKTSLEevkginlsygknlgkLFLEKIDEEKKKSEHMIKAMEAYIEDLDEI--- 1255

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   992 ltKEKKALQEAHQQALDDLQAEEDKVNT--------LTKAKVKLEQQVDDLEGSLE--QEKKVRMDLERAKRKLEGDLKL 1061
Cdd:TIGR01612 1256 --KEKSPEIENEMGIEMDIKAEMETFNIshdddkdhHIISKKHDENISDIREKSLKiiEDFSEESDINDIKKELQKNLLD 1333

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1062 TQE----------------SIMDLENDKQQLDErLKKKDFELNALNARIEDEQALGSQLQKK------LKELQARIEELE 1119
Cdd:TIGR01612 1334 AQKhnsdinlylneianiyNILKLNKIKKIIDE-VKEYTKEIEENNKNIKDELDKSEKLIKKikddinLEECKSKIESTL 1412

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1120 EELEAERTARaKVEKLRSDLSRELEEISERLEEAGGATS------VQIEMNKKREAEFQKMRRDleEATLQHEATAAALr 1193
Cdd:TIGR01612 1413 DDKDIDECIK-KIKELKNHILSEESNIDTYFKNADENNEnvlllfKNIEMADNKSQHILKIKKD--NATNDHDFNINEL- 1488

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1194 KKHADSVAELGEQIDnlqRVKQKLEKEKSEFKLELDDVT-------------------SNMEQIIK-------------- 1240
Cdd:TIGR01612 1489 KEHIDKSKGCKDEAD---KNAKAIEKNKELFEQYKKDVTellnkysalaiknkfaktkKDSEIIIKeikdahkkfileae 1565

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1241 ---AKAANLEKMCRTLEDQM--NEHRSKAE-ETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTrgkltyTQQLE 1314
Cdd:TIGR01612 1566 kseQKIKEIKKEKFRIEDDAakNDKSNKAAiDIQLSLENFENKFLKISDIKKKINDCLKETESIEKKIS------SFSID 1639

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1315 DLKRQLEEEVKAKNALAHALQSarhdcdlLREQYEEETEAKAELQRVLSKANS---EVAQWRTKYETDAIQRTEELEEAK 1391
Cdd:TIGR01612 1640 SQDTELKENGDNLNSLQEFLES-------LKDQKKNIEDKKKELDELDSEIEKieiDVDQHKKNYEIGIIEKIKEIAIAN 1712

                          650
                   ....*....|....*.
gi 119586555  1392 KklaQRLQEAEEAVEA 1407
Cdd:TIGR01612 1713 K---EEIESIKELIEP 1725
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1623-1764 9.25e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 9.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1623 LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA---------ELEELRAVV 1693
Cdd:COG1579    19 LDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlgnvrnnkEYEALQKEI 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555 1694 EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAA 1764
Cdd:COG1579    99 ESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELA 169
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1579-1923 1.04e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 43.73  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1579 EKDEEMEQAKRNHLRVVDS---LQTSLDAETRSRNEALR----VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL 1651
Cdd:pfam07888   10 EEESHGEEGGTDMLLVVPRaelLQNRLEECLQERAELLQaqeaANRQREKEKERYKRDREQWERQRRELESRVAELKEEL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1652 KDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM 1731
Cdd:pfam07888   90 RQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEE 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1732 DADLSQLQTEVEEAVQECRNaeekakkaitdaamMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ--IALKGG 1809
Cdd:pfam07888  170 EAERKQLQAKLQQTEEELRS--------------LSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRkeAENEAL 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1810 KKQLQKLEARVRELENELEAeQKRNAESVKGMRksERRIKELTYQTEEDRKNLLRLQDLvdKLQLKVKAYKRQAEEAEEQ 1889
Cdd:pfam07888  236 LEELRSLQERLNASERKVEG-LGEELSSMAAQR--DRTQAELHQARLQAAQLTLQLADA--SLALREGRARWAQERETLQ 310

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 119586555  1890 ANTNLSKFR--KVQHELDEAEERADIAESQVNKLRA 1923
Cdd:pfam07888  311 QSAEADKDRieKLSAELQRLEERLQEERMEREKLEV 346
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1767-1918 1.05e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.08  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1767 AEELKKEQDTSAHLERMKKNMEQTIKDLQhrldeaeqialkggkKQLQKLEARVRELENELEAEQKRNAES---VKGMRK 1843
Cdd:COG2433   391 PEEEPEAEREKEHEERELTEEEEEIRRLE---------------EQVERLEAEVEELEAELEEKDERIERLereLSEARS 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1844 SERR-------IKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRqAEEAEEQANT----NLSKFRKvqHELDEAEERAD 1912
Cdd:COG2433   456 EERReirkdreISRLDREIERLERELEEERERIEELKRKLERLKE-LWKLEHSGELvpvkVVEKFTK--EAIRRLEEEYG 532


                  ....*.
gi 119586555 1913 IAESQV 1918
Cdd:COG2433   533 LKEGDV 538
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1274-1910 1.17e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.04  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1274 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTY--------------------------------TQQLEDLKRQLE 1321
Cdd:pfam10174    1 LQAQLRDLQRENELLRRELDIKESKLGSSMNSIKTFwspelkkeralrkeeaarisvlkeqyrvtqeeNQHLQLTIQALQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1322 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSevaqwRTKYETDAIQRT-EELE------------ 1388
Cdd:pfam10174   81 DELRAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHE-----RQAKELFLLRKTlEEMElrietqkqtlga 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1389 --EAKKKLAQRLQ------EAEEAVEAVNAKCSSLEKTKHRL-----QNEIEDLMVDVE-RSNAAAAALDKKQRNFDKIL 1454
Cdd:pfam10174  156 rdESIKKLLEMLQskglpkKSGEEDWERTRRIAEAEMQLGHLevlldQKEKENIHLREElHRRNQLQPDPAKTKALQTVI 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1455 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL 1534
Cdd:pfam10174  236 EMKDTKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKIDQLKQELSKKESELLALQTKLETL 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1535 EAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKlaekdEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALR 1614
Cdd:pfam10174  316 TNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK-----ESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLD 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1615 VKKK----MEGDLNEMEIQLSHANRMAAEAQKQVKSLQ-------SLLKDTQIQLDDAVRANDDLKENIaivERRNNLLQ 1683
Cdd:pfam10174  391 VKERkinvLQKKIENLQEQLRDKDKQLAGLKERVKSLQtdssntdTALTTLEEALSEKERIIERLKEQR---EREDRERL 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1684 AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAitda 1763
Cdd:pfam10174  468 EELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKA---- 543

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1764 ammaeelkkeqDTSAHLERMKKNMEQTIKDLQHrldEAEQIALKGGKKQ--LQKLEARVRELENELEAEQKRNAE----- 1836
Cdd:pfam10174  544 -----------HNAEEAVRTNPEINDRIRLLEQ---EVARYKEESGKAQaeVERLLGILREVENEKNDKDKKIAEleslt 609

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555  1837 --SVKGMRKSERRIKELtyQTEEDRKNLLRLQD-LVDKLQLKVKAYKRQAEEAeeqantnLSKFRKVQHELDEAEER 1910
Cdd:pfam10174  610 lrQMKEQNKKVANIKHG--QQEMKKKGAQLLEEaRRREDNLADNSQQLQLEEL-------MGALEKTRQELDATKAR 677
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
 852-1106 1.18e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 44.07  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  852 MKEEFTRLKEALEKSEARRK----ELEEKMVSLLQEKN------------DLQLQVQAEQDNLADAEERCDQLIKNKIQL 915
Cdd:PLN03229  484 LQERLENLREEFSKANSQDQlmhpVLMEKIEKLKDEFNkrlsrapnylslKYKLDMLNEFSRAKALSEKKSKAEKLKAEI 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  916 EAKVKEMNERLEDEEEMNAeltakkRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMaGLDEIIAKltke 995
Cdd:PLN03229  564 NKKFKEVMDRPEIKEKMEA------LKAEVASSGASSGDELDDDLKEKVEKMKKEIELELAGVLKSM-GLEVIGVT---- 632

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  996 KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKkvrmdLERAKRKLEGDLKlTQESIMDLEND-KQ 1074
Cdd:PLN03229  633 KKNKDTAEQTPPPNLQEKIESLNEEINKKIERVIRSSDLKSKIELLK-----LEVAKASKTPDVT-EKEKIEALEQQiKQ 706

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 119586555 1075 QLDE-----RLKKKDFELNA-LNARIEDEQALGSQLQK 1106
Cdd:PLN03229  707 KIAEalnssELKEKFEELEAeLAAARETAAESNGSLKN 744
PRK09039 PRK09039
peptidoglycan -binding protein;
1076-1238 1.25e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 43.42  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1076 LDERLKKKDFELNALNARIED-------EQALGSQLQKKLKELQARIEELEEEleaertaRAKVEKLRSDLSRELEEISE 1148
Cdd:PRK09039   44 LSREISGKDSALDRLNSQIAEladllslERQGNQDLQDSVANLRASLSAAEAE-------RSRLQALLAELAGAGAAAEG 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1149 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL---RKKHADS---VAELGEQIDN--LQRVKQkLEKE 1220
Cdd:PRK09039  117 RAGELAQELDSEKQVSARALAQVELLNQQIAALRRQLAALEAALdasEKRDRESqakIADLGRRLNValAQRVQE-LNRY 195

                         170
                  ....*....|....*...
gi 119586555 1221 KSEFKLELDDVTSNMEQI 1238
Cdd:PRK09039  196 RSEFFGRLREILGDREGI 213
PLN03188 PLN03188
kinesin-12 family protein; Provisional
 1650-1924 1.26e-03

kinesin-12 family protein; Provisional


Pssm-ID: 215621 [Multi-domain]  Cd Length: 1320  Bit Score: 44.16  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1650 LLKDTQIQLDDAVRANDDLKEniaiverrnnlLQAELEELRAVVEQTERSRKLAE-QELietseRVQLLHSQNTSLINQK 1728
Cdd:PLN03188  951 LLKEKYENHPEVLRTKIELKR-----------VQDELEHYRNFYDMGEREVLLEEiQDL-----RSQLQYYIDSSLPSAR 1014

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1729 KK---------MDADLSQLQTEVEEAVQECrnAEEKAKK-------AITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1792
Cdd:PLN03188 1015 KRnsllkltysCEPSQAPPLNTIPESTDES--PEKKLEQerlrwteAESKWISLAEELRTELDASRALAEKQKHELDTEK 1092

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1793 DLQHRLDEAEQIALKGGKKQLQK----------LEARVRELENELEAEQKrnAESVKGMRKSERR--------IKELTYQ 1854
Cdd:PLN03188 1093 RCAEELKEAMQMAMEGHARMLEQyadleekhiqLLARHRRIQEGIDDVKK--AAARAGVRGAESKfinalaaeISALKVE 1170

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555 1855 TEEDRKnllRLQDLVDKLQLKVkaykRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE-------SQVNKLRAK 1924
Cdd:PLN03188 1171 REKERR---YLRDENKSLQAQL----RDTAEAVQAAGELLVRLKEAEEALTVAQKRAMDAEqeaaeayKQIDKLKRK 1240
PRK15374 PRK15374
type III secretion system needle tip complex protein SipB;
914-1115 1.27e-03

type III secretion system needle tip complex protein SipB;


Pssm-ID: 185272 [Multi-domain]  Cd Length: 593  Bit Score: 43.80  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  914 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 993
Cdd:PRK15374  103 QLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAAEKKLTQAQNKLQSLDPADPGYA 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  994 KEKKALQEAHQQALDDLQAEEDK----VNTLTKAKVKLEQQvDDLEGSLEQEKKVRMDLERAK---RKLEGDLKLTQESI 1066
Cdd:PRK15374  183 QAEAAVEQAGKEATEAKEALDKAtdatVKAGTDAKAKAEKA-DNILTKFQGTANAASQNQVSQgeqDNLSNVARLTMLMA 261

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 119586555 1067 MDLENDKQQLDERLKKkdfELNALNARIEDEQAlgsQLQKKLKELQARI 1115
Cdd:PRK15374  262 MFIEIVGKNTEESLQN---DLALFNALQEGRQA---EMEKKSAEFQEET 304
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 1210-1335 1.40e-03

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 41.46  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1210 LQRVKQkLEKEKSEFKLELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELS 1289
Cdd:pfam08614   13 LDRTAL-LEAENAKLQSEPESVLPSTSSSKLSKASPQSASIQSLEQLLAQLREELAELYRSRGELAQRLVDLNEELQELE 91

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 119586555  1290 RQLDEKEALISQLTRGKltytQQLEDLKRQLEEEVKAKNALAHALQ 1335
Cdd:pfam08614   92 KKLREDERRLAALEAER----AQLEEKLKDREEELREKRKLNQDLQ 133
Filament pfam00038
Intermediate filament protein;
1128-1362 1.42e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 42.99  E-value: 1.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1128 ARAKVEKLRSDLSRELEEISERLEEaggatsvqiEMNKKR--EAEFQKMRRDLEEATLQH---EATA-------AALRKK 1195
Cdd:pfam00038   69 ERARLQLELDNLRLAAEDFRQKYED---------ELNLRTsaENDLVGLRKDLDEATLARvdlEAKIeslkeelAFLKKN 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1196 HADSVAELGEQIDNLQRVkqklekeksefkLELDDVTS-NMEQIIKAKAANLEKMC-RTLEDQMNEHRSKAEETQRSVND 1273
Cdd:pfam00038  140 HEEEVRELQAQVSDTQVN------------VEMDAARKlDLTSALAEIRAQYEEIAaKNREEAEEWYQSKLEELQQAAAR 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1274 LTSQRAKLQTENGELSRQLDEKEALISQLTRgkltytqQLEDLKRQLEEevkAKNALAHALQSARhdcDLLREQYEEETE 1353
Cdd:pfam00038  208 NGDALRSAKEEITELRRTIQSLEIELQSLKK-------QKASLERQLAE---TEERYELQLADYQ---ELISELEAELQE 274


                   ....*....
gi 119586555  1354 AKAELQRVL 1362
Cdd:pfam00038  275 TRQEMARQL 283
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 846-1115 1.49e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 43.59  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDN--LADAEERCDQLIKNKIQLEAKVKEmN 923
Cdd:pfam09731  160 KAHTDSLKEASDTAEISREKATDSALQKAEALAEKLKEVINLAKQSEEEAAPplLDAAPETPPKLPEHLDNVEEKVEK-A 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   924 ERLEDEEEMNAELTAKKRklEDECSELKRDIDDLELTLAKVEKEKHATENKVknLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Cdd:pfam09731  239 QSLAKLVDQYKELVASER--IVFQQELVSIFPDIIPVLKEDNLLSNDDLNSL--IAHAHREIDQLSKKLAELKKREEKHI 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD-----LENDKQQLDE 1078
Cdd:pfam09731  315 ERALEKQKEELDKLAEELSARLEEVRAADEAQLRLEFEREREEIRESYEEKLRTELERQAEAHEEhlkdvLVEQEIELQR 394

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 119586555  1079 RLKKKdfelnaLNARIEDEQALgsqLQKKLKELQARI 1115
Cdd:pfam09731  395 EFLQD------IKEKVEEERAG---RLLKLNELLANL 422
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1389-1620 1.51e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1389 EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL 1468
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1469 ESSQKEARSLSTELFKLKNAYEESL----EHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSA 1544
Cdd:COG4942   100 EAQKEELAELLRALYRLGRQPPLALllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555 1545 LEEAEASleheegkilraqlefnqiKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKME 1620
Cdd:COG4942   180 LAELEEE------------------RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1188-1304 1.54e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 43.53  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1188 TAAALRKKHADSVAElgeQIDNLQRVKQKLEKEKSEFKLELDDVTsnmeqiiKAKAANLEKMCRTLEDQMNEHRSKAEET 1267
Cdd:COG0542   397 EAAARVRMEIDSKPE---ELDELERRLEQLEIEKEALKKEQDEAS-------FERLAELRDELAELEEELEALKARWEAE 466

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 119586555 1268 QRSVNDLTSQRAKLQTENG---ELSRQLDEKEALISQLTR 1304
Cdd:COG0542   467 KELIEEIQELKEELEQRYGkipELEKELAELEEELAELAP 506
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1071-1851 1.61e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 43.79  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1071 NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAE-------RTARAKVEKLRSdLSREL 1143
Cdd:COG3096   278 NERRELSERALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAAsdhlnlvQTALRQQEKIER-YQEDL 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1144 EEISERLEEAGGAtsvqiemnkkreaefqkmrrdLEEATLQHEATAAALRKKHaDSVAELGEQIDNLQRV---------- 1213
Cdd:COG3096   357 EELTERLEEQEEV---------------------VEEAAEQLAEAEARLEAAE-EEVDSLKSQLADYQQAldvqqtraiq 414

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1214 -KQKLE-KEKSEFKLELDDVT----SNMEQIIKAKAANLEKMCRTLEDQMN---EHRS---KAEETQRSVNDLTSQRAKL 1281
Cdd:COG3096   415 yQQAVQaLEKARALCGLPDLTpenaEDYLAAFRAKEQQATEEVLELEQKLSvadAARRqfeKAYELVCKIAGEVERSQAW 494

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1282 QTENgELSRQLDEKEALISQLTrgklTYTQQLEDLKRQLEEEVKAK---NALAHALQSARHDCDLLREQYEEETEAKAEL 1358
Cdd:COG3096   495 QTAR-ELLRRYRSQQALAQRLQ----QLRAQLAELEQRLRQQQNAErllEEFCQRIGQQLDAAEELEELLAELEAQLEEL 569

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1359 QRVLSKANSEVAQWRtkyetdaiQRTEELEEAKKKLAQR---LQEAEEAVEAVNAKC-----SSLEKTKHR---LQNEIE 1427
Cdd:COG3096   570 EEQAAEAVEQRSELR--------QQLEQLRARIKELAARapaWLAAQDALERLREQSgealaDSQEVTAAMqqlLERERE 641

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1428 dlmVDVERSNAAAA--ALDKKQRN-------FDKILAEWKQKYeesqselessqkeARSLSTELFK---LKNA-YEESL- 1493
Cdd:COG3096   642 ---ATVERDELAARkqALESQIERlsqpggaEDPRLLALAERL-------------GGVLLSEIYDdvtLEDApYFSALy 705

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1494 ---------EHLETFKRENKNLQEEISDL-----TEQLGS-SGKTIHELEK---VR-----------------------K 1532
Cdd:COG3096   706 gparhaivvPDLSAVKEQLAGLEDCPEDLyliegDPDSFDdSVFDAEELEDavvVKlsdrqwrysrfpevplfgraareK 785

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1533 QLEAEKMELQsALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME-QAKRNHLRVVDSLQTSLDAETRSRNE 1611
Cdd:COG3096   786 RLEELRAERD-ELAEQYAKASFDVQKLQRLHQAFSQFVGGHLAVAFAPDPEAElAALRQRRSELERELAQHRAQEQQLRQ 864

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1612 ALRVKKKMEGDLNEMeiqLSHANRMAAEaqkqvkSLQSLLKDTQIQLDDAVRANDDLKEN---IAIVERRNNLLQ---AE 1685
Cdd:COG3096   865 QLDQLKEQLQLLNKL---LPQANLLADE------TLADRLEELREELDAAQEAQAFIQQHgkaLAQLEPLVAVLQsdpEQ 935

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1686 LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLS-QLQTEVEEAVQECRNAEEKAKKA---IT 1761
Cdd:COG3096   936 FEQLQADYLQAKEQQRRLKQQIFALSEVVQRRPHFSYEDAVGLLGENSDLNeKLRARLEQAEEARREAREQLRQAqaqYS 1015

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1762 DAAMMAEELKKEQDTSAhleRMKKNMEQTIKDLQHRLD-EAEQIAlkggkkqlqklEARVRELENELEAEQKRNAESVKG 1840
Cdd:COG3096  1016 QYNQVLASLKSSRDAKQ---QTLQELEQELEELGVQADaEAEERA-----------RIRRDELHEELSQNRSRRSQLEKQ 1081

                         890
                  ....*....|.
gi 119586555 1841 MRKSERRIKEL 1851
Cdd:COG3096  1082 LTRCEAEMDSL 1092
ATG14 pfam10186
Vacuolar sorting 38 and autophagy-related subunit 14; The Atg14 or Apg14 proteins are ...
 852-998 1.73e-03

Vacuolar sorting 38 and autophagy-related subunit 14; The Atg14 or Apg14 proteins are hydrophilic proteins with a predicted molecular mass of 40.5 kDa, and have a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY), a vacuolar-soluble hydrolase, to the vacuole. Subcellular fractionation indicate that Apg14p and Apg6p are peripherally associated with a membrane structure(s). Apg14p was co-immunoprecipitated with Apg6p, suggesting that they form a stable protein complex. These results imply that Apg6/Vps30p has two distinct functions: in the autophagic process and in the vacuolar protein sorting pathway. Apg14p may be a component specifically required for the function of Apg6/Vps30p through the autophagic pathway. There are 17 auto-phagosomal component proteins which are categorized into six functional units, one of which is the AS-PI3K complex (Vps30/Atg6 and Atg14). The AS-PI3K complex and the Atg2-Atg18 complex are essential for nucleation, and the specific function of the AS-PI3K apparently is to produce phosphatidylinositol 3-phosphate (PtdIns(3)P) at the pre-autophagosomal structure (PAS). The localization of this complex at the PAS is controlled by Atg14. Autophagy mediates the cellular response to nutrient deprivation, protein aggregation, and pathogen invasion in humans, and malfunction of autophagy has been implicated in multiple human diseases including cancer. This effect seems to be mediated through direct interaction of the human Atg14 with Beclin 1 in the human phosphatidylinositol 3-kinase class III complex.


Pssm-ID: 462986 [Multi-domain]  Cd Length: 347  Bit Score: 42.83  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   852 MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAeercdQLIKNKI-QLEAKVKEMNERLEdee 930
Cdd:pfam10186   17 ARNRLYELRVDLARLLSEKDSLKKKVEEALEGKEEGEQLEDNIGNKKLKL-----RLLKSEVaISNERLNEIKDKLD--- 88

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119586555   931 EMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 998
Cdd:pfam10186   89 QLRREIAEKKKKIEKLRSSLKQRRSDLESASYQLEERRASQLAKLQNSIKRIKQKWTALHSKTAESRS 156
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1563-1837 1.81e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 43.50  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1563 QLEFNQIKAEIERklAEKDEEMEQAKrnhlrVVDSLQTSLDAetrsrnealrvkkkmegdLNEMEIqlshANRMAAEAQK 1642
Cdd:PRK10929   22 APDEKQITQELEQ--AKAAKTPAQAE-----IVEALQSALNW------------------LEERKG----SLERAKQYQQ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1643 QVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE---LEELRAVVEQTERSRKLAE-------------QE 1706
Cdd:PRK10929   73 VIDNFPKLSAELRQQLNNERDEPRSVPPNMSTDALEQEILQVSsqlLEKSRQAQQEQDRAREISDslsqlpqqqtearRQ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1707 LIETSERVQLLHSQNTSLiNQkkkmdADLSQLQteveeavqecrnAEEKAKKAITDaammaeELKkeqdtsahLERMKKN 1786
Cdd:PRK10929  153 LNEIERRLQTLGTPNTPL-AQ-----AQLTALQ------------AESAALKALVD------ELE--------LAQLSAN 200

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 119586555 1787 MEQTIKDLQHRLdeaeqialkgGKKQLQKLEARVRELENELEAEQKRNAES 1837
Cdd:PRK10929  201 NRQELARLRSEL----------AKKRSQQLDAYLQALRNQLNSQRQREAER 241
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
948-1256 1.92e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.58  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  948 SELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKL 1027
Cdd:COG4372    27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1028 EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE--DEQALGSQLQ 1105
Cdd:COG4372   107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQalSEAEAEQALD 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1106 KKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA----GGATSVQIEMNKKREAEFQKMRRDLEEA 1181
Cdd:COG4372   187 ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLAlsalLDALELEEDKEELLEEVILKEIEELELA 266

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119586555 1182 TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAANLEKMCRTLEDQ 1256
Cdd:COG4372   267 ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELAD 341
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 846-1036 1.94e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.29  E-value: 1.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   846 EKEMASMKEEFTR-LKEALEKSEARRKELEE----KMVSLLQEKNDLQLQVQAEQDNLAdaEERCDQLIK------NKIQ 914
Cdd:pfam12128  695 DKKHQAWLEEQKEqKREARTEKQAYWQVVEGaldaQLALLKAAIAARRSGAKAELKALE--TWYKRDLASlgvdpdVIAK 772

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   915 LEAKVKEMNERLEDEEEMNAE------------------LTAKKRKLEDECSELK----RDIDDLELTLAKVEKEKHATE 972
Cdd:pfam12128  773 LKREIRTLERKIERIAVRRQEvlryfdwyqetwlqrrprLATQLSNIERAISELQqqlaRLIADTKLRRAKLEMERKASE 852

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119586555   973 NKVKNLTEEMAGLDEIIAKLT--KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEG 1036
Cdd:pfam12128  853 KQQVRLSENLRGLRCEMSKLAtlKEDANSEQAQGSIGERLAQLEDLKLKRDYLSESVKKYVEHFKN 918
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 841-1082 2.22e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.96  E-value: 2.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920
Cdd:pfam07888  144 RVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLT 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   921 EMNERLEDEEEMNAELTAKKRKLE--DECSE-LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMA----GLDEIIAKLT 993
Cdd:pfam07888  224 TAHRKEAENEALLEELRSLQERLNasERKVEgLGEELSSMAAQRDRTQAELHQARLQAAQLTLQLAdaslALREGRARWA 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   994 KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKV-RMDLERAKRKLE---GDLKLTQESIMDL 1069
Cdd:pfam07888  304 QERETLQQSAEADKDRIEKLSAELQRLEERLQEERMEREKLEVELGREKDCnRVQLSESRRELQelkASLRVAQKEKEQL 383

                          250
                   ....*....|...
gi 119586555  1070 ENDKQQLDERLKK 1082
Cdd:pfam07888  384 QAEKQELLEYIRQ 396
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 1586-1860 2.24e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.49  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1586 QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSllkdtqiQLDDAVRAN 1665
Cdd:pfam15905   66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEK-------QLLELTRVN 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1666 DDLKENIAI--VERRNNLLQAELEELRAVVEQTERSrKLAEQELIEtserVQLLHSQNTslINQKKKMDADLSQLQTEVE 1743
Cdd:pfam15905  139 ELLKAKFSEdgTQKKMSSLSMELMKLRNKLEAKMKE-VMAKQEGME----GKLQVTQKN--LEHSKGKVAQLEEKLVSTE 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1744 EAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAlkggKKQLQKLEARVREL 1823
Cdd:pfam15905  212 KEKIEEKSETEKLLEYITELSCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQSLEEKEQEL----SKQIKDLNEKCKLL 287

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 119586555  1824 ENELEAEQKRNAESVKGMRKSERRIKE-LTYQTEEDRK 1860
Cdd:pfam15905  288 ESEKEELLREYEEKEQTLNAELEELKEkLTLEEQEHQK 325
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 847-1043 2.31e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 41.55  E-value: 2.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEM---- 922
Cdd:pfam00261    1 KKMQQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEKAADESergr 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   923 ----NERLEDEEEMN---AELTAKKRKLED---ECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 992
Cdd:pfam00261   81 kvleNRALKDEEKMEileAQLKEAKEIAEEadrKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSL 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 119586555   993 -TKEKKALQ------EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043
Cdd:pfam00261  161 eASEEKASEredkyeEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDELEAEKE 218
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1024-1428 2.35e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 42.81  E-value: 2.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1024 KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDfelNALNARIEDEQALGSQ 1103
Cdd:pfam05557    8 KARLSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAE---EALREQAELNRLKKKY 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSvQIEMNKKREAEFQKMRRDLEEAtl 1183
Cdd:pfam05557   85 LEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQE-RLDLLKAKASEAEQLRQNLEKQ-- 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1184 QHEATAAALRKK--------HADSVAELG------EQIDNLQRVKQKLEKE----------KSEFKLELDDVTSNMEQI- 1238
Cdd:pfam05557  162 QSSLAEAEQRIKelefeiqsQEQDSEIVKnskselARIPELEKELERLREHnkhlnenienKLLLKEEVEDLKRKLEREe 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1239 -IKAKAANLEKMCRTLEDQMNEHRSKAEETQ---RSVNDLTSQRAKLQT-------ENGELSRQLDEKEALISQLTRGKL 1307
Cdd:pfam05557  242 kYREEAATLELEKEKLEQELQSWVKLAQDTGlnlRSPEDLSRRIEQLQQreivlkeENSSLTSSARQLEKARRELEQELA 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1308 TYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR---EQYEEETeakaelqrvlskANSEVAQWRTKYETDAIQRT 1384
Cdd:pfam05557  322 QYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRailESYDKEL------------TMSNYSPQLLERIEEAEDMT 389

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 119586555  1385 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEK--TKHRLQNEIED 1428
Cdd:pfam05557  390 QKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERelQALRQQESLAD 435
FPP pfam05911
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ...
 1165-1321 2.38e-03

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.


Pssm-ID: 461778 [Multi-domain]  Cd Length: 859  Bit Score: 43.13  E-value: 2.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1165 KKREAEFQKMRRDLEEATLQheATAAALRKKHADS-VAELGEQIDNLqrvkqkleKEKSEFKLEldDVtsnmeqiIKAKA 1243
Cdd:pfam05911   20 EKAEAEALALKQQLESVTLQ--KLTAEERAAHLDGaLKECMQQLRNV--------KEEQEQKIH--DV-------VLKKT 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119586555  1244 ANLEKMCRTLEDQMNEhrskaeetqrsvndlTSQR-AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE 1321
Cdd:pfam05911   81 KEWEKIKAELEAKLVE---------------TEQElLRAAAENDALSRSLQERENLLMKLSEEKSQAEAEIEALKSRLE 144
Caldesmon pfam02029
Caldesmon;
1641-1887 2.55e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 42.55  E-value: 2.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1641 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHsQ 1720
Cdd:pfam02029   69 AKREERRQKRLQEALERQKEFDPTIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWS-T 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1721 NTSLINQKKKMDADLSQLQTEVE------EAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1794
Cdd:pfam02029  148 EVRQAEEEGEEEEDKSEEAEEVPtenfakEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQ 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1795 ----QHRLDEAEQIALKGGKKQLQKLEARVRELENElEAEQKRNA--------ESVKGMRKSERRIKELTYQTEEDRKNL 1862
Cdd:pfam02029  228 gglsQSQEREEEAEVFLEAEQKLEELRRRRQEKESE-EFEKLRQKqqeaelelEELKKKREERRKLLEEEEQRRKQEEAE 306

                          250       260
                   ....*....|....*....|....*
gi 119586555  1863 LRLQDLVDKLQLKVKAYKRQAEEAE 1887
Cdd:pfam02029  307 RKLREEEEKRRMKEEIERRRAEAAE 331
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 839-1112 2.55e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.85  E-value: 2.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   839 LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEekmvsllQEKNDLqlqvqaeQDNLADAEERCDQLIKNKIQLEAK 918
Cdd:pfam01576  825 LAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQ-------QERDEL-------ADEIASGASGKSALQDEKRRLEAR 890

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   919 VKEMNERLEdEEEMNAELTAKK-RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEmagldeiiakltkekk 997
Cdd:pfam01576  891 IAQLEEELE-EEQSNTELLNDRlRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAK---------------- 953

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   998 alqeahqqalddLQAEEDKVNTLTKAKVK-LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076
Cdd:pfam01576  954 ------------LQEMEGTVKSKFKSSIAaLEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQY 1021

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 119586555  1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
Cdd:pfam01576 1022 KDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQ 1057
PRK11281 PRK11281
mechanosensitive channel MscK;
923-1320 2.64e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.98  E-value: 2.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  923 NERLEDEEEMNAEL-TAKKRKLEDEcsELKRDIDDLELTL---AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 998
Cdd:PRK11281   32 NGDLPTEADVQAQLdALNKQKLLEA--EDKLVQQDLEQTLallDKIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDD 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  999 LQEAHQQALDDLQAEEdkvntltkakvkLEQQVDDLEGSLEQekkVRMDL--------------ERAKRKLEGDLKLTQE 1064
Cdd:PRK11281  110 NDEETRETLSTLSLRQ------------LESRLAQTLDQLQN---AQNDLaeynsqlvslqtqpERAQAALYANSQRLQQ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1065 ----SIMDLENDKQQLDERLKKKDFELNALNARIEDEQAL---GSQLQ----KKLKELQARIEELEEELEAERTArakVE 1133
Cdd:PRK11281  175 irnlLKGGKVGGKALRPSQRVLLQAEQALLNAQNDLQRKSlegNTQLQdllqKQRDYLTARIQRLEHQLQLLQEA---IN 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1134 KLRSDLSRELEEISERLEEAGgatsvQIEMNK--KREAEF-QKMRRDLEEATLQ-HEATAAALRKKHA-DSVAE----LG 1204
Cdd:PRK11281  252 SKRLTLSEKTVQEAQSQDEAA-----RIQANPlvAQELEInLQLSQRLLKATEKlNTLTQQNLRVKNWlDRLTQsernIK 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1205 EQIDNLQ------RV--KQKLekeksefKLELDDVTSNM-EQIikakaANLekmcRTLEDQMNEHRSKAEETQRSVNDLt 1275
Cdd:PRK11281  327 EQISVLKgslllsRIlyQQQQ-------ALPSADLIEGLaDRI-----ADL----RLEQFEINQQRDALFQPDAYIDKL- 389

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 119586555 1276 sqrakLQTENGELSRQldEKEALISQL-TRGKLtytqqLEDLKRQL 1320
Cdd:PRK11281  390 -----EAGHKSEVTDE--VRDALLQLLdERREL-----LDQLNKQL 423
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 852-1577 2.69e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 42.90  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  852 MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMN-------- 923
Cdd:PTZ00440  726 YTIKYNDLKSSIEEYKEEEEKLEVYKHQIINRKNEFILHLYENDKDLPDGKNTYEEFLQYKDTILNKENKISndinilke 805

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  924 ----------------ERLEDEEEMNAE-------------LTAKKRKLEDECSELKRDID----DLEL------TLAKV 964
Cdd:PTZ00440  806 nkknnqdllnsyniliQKLEAHTEKNDEelkqllqkfptedENLNLKELEKEFNENNQIVDniikDIENmnkninIIKTL 885

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  965 EKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ-------EAHQQALDDLQAEEDKVNT------LTKAKVKLEQQV 1031
Cdd:PTZ00440  886 NIAINRSNSNKQLVEHLLNNKIDLKNKLEQHMKIINtdniiqkNEKLNLLNNLNKEKEKIEKqlsdtkINNLKMQIEKTL 965

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1032 D-----------DLEGSLEQEKKVRMDLERAKRKLEG---DLKLTQESIMDLENDKQQ-----LDERLKKKDfelNALNA 1092
Cdd:PTZ00440  966 EyydkskeningNDGTHLEKLDKEKDEWEHFKSEIDKlnvNYNILNKKIDDLIKKQHDdiielIDKLIKEKG---KEIEE 1042

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1093 RIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE-----AGGATSVQIEMNKKR 1167
Cdd:PTZ00440 1043 KVDQYISLLEKMKTKLSSFHFNIDIKKYKNPKIKEEIKLLEEKVEALLKKIDENKNKLIEiknksHEHVVNADKEKNKQT 1122

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1168 EAeFQKMRRDLEEATLQHEATAAALRKKH-----ADSVAELGEQIDNL--QRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1240
Cdd:PTZ00440 1123 EH-YNKKKKSLEKIYKQMEKTLKELENMNleditLNEVNEIEIEYERIliDHIVEQINNEAKKSKTIMEEIESYKKDIDQ 1201

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1241 AKAANL-EKMCRTLEDQMNEHRSKAEETQRSVNDLTsQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ 1319
Cdd:PTZ00440 1202 VKKNMSkERNDHLTTFEYNAYYDKATASYENIEELT-TEAKGLKGEANRSTNVDELKEIKLQVFSYLQQVIKENNKMENA 1280

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1320 LeEEVKAKNALAHALQSARHDCDLLREQYEEET---EAKAELQ---RVLSKANSEVAQWRT-KYETDAIQRTEELEEAKK 1392
Cdd:PTZ00440 1281 L-HEIKNMYEFLISIDSEKILKEILNSTKKAEEfsnDAKKELEktdNLIKQVEAKIEQAKEhKNKIYGSLEDKQIDDEIK 1359

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1393 KLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEdlmvDVERSNAAAAALDKKQRNFDKILAEWK-QKYEESQSELESS 1471
Cdd:PTZ00440 1360 KIEQIKEEISNKRKEINKYLSNIKSNKEKCDLHVR----NASRGKDKIDFLNKHEAIEPSNSKEVNiIKITDNINKCKQY 1435

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1472 QKEARSLSTELFKLKNA---YEESLEH-------------LETFKRENKNLQEEI----SDLTEQLGSSGKTIHELEKVR 1531
Cdd:PTZ00440 1436 SNEAMETENKADENNDSiikYEKEITNilnnssilgkktkLEKKKKEATNIMDDIngehSIIKTKLTKSSEKLNQLNEQP 1515

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*.
gi 119586555 1532 KQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1577
Cdd:PTZ00440 1516 NIKREGDVLNNDKSTIAYETIQYNLGRVKHNLLNILNIKDEIETIL 1561
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 902-1043 2.84e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.93  E-value: 2.84e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    902 EERCDQLIKNKIQLEAKVKEMNErleDEEEMNAELTakkrkledECSELKRDIDDLELTL-AKVEKEKHATENKVKNLTE 980
Cdd:smart00787  136 EWRMKLLEGLKEGLDENLEGLKE---DYKLLMKELE--------LLNSIKPKLRDRKDALeEELRQLKQLEDELEDCDPT 204

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119586555    981 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043
Cdd:smart00787  205 ELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG 267
PRK12704 PRK12704
phosphodiesterase; Provisional
 1750-1915 2.90e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1750 RNAEEKAKKAITDAAMMAEELKKEqdtsahLERMKKNMEQTIKDLQHRLdeaeqialkggkkqLQKLEARVRELENELEA 1829
Cdd:PRK12704   27 KIAEAKIKEAEEEAKRILEEAKKE------AEAIKKEALLEAKEEIHKL--------------RNEFEKELRERRNELQK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1830 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAnTNLSKFRKVQHELDEAEE 1909
Cdd:PRK12704   87 LEKRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERI-SGLTAEEAKEILLEKVEE 165


                  ....*...
gi 119586555 1910 --RADIAE 1915
Cdd:PRK12704  166 eaRHEAAV 173
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 1735-1921 3.05e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 41.55  E-value: 3.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1735 LSQLQTEVEEAVQECRNAEEK---AKKAITDAAMMAEELKKE-QDTSAHLERMKKNMEQTikdlQHRLDEAEQIA----- 1805
Cdd:pfam00261    3 MQQIKEELDEAEERLKEAMKKleeAEKRAEKAEAEVAALNRRiQLLEEELERTEERLAEA----LEKLEEAEKAAdeser 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1806 -LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTE--EDRKNLL--RLQDLVDKLQL---KVK 1877
Cdd:pfam00261   79 gRKVLENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLEraEERAELAesKIVELEEELKVvgnNLK 158

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 119586555  1878 AYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1921
Cdd:pfam00261  159 SLEASEEKASEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKL 202
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 840-1017 3.23e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.31  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  840 LKSAEREKEmaSMKEEFTRLK-----------EALEKSEARRKELEEKMVSLlQEKNDLQ-------LQVQAEQDNLADA 901
Cdd:NF033838  206 IKQAKAKVE--SKKAEATRLEkiktdrekaeeEAKRRADAKLKEAVEKNVAT-SEQDKPKrrakrgvLGEPATPDKKEND 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  902 EERCDQLI-------------KNKIQLEAKVKEMNERLED--EEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK 966
Cdd:NF033838  283 AKSSDSSVgeetlpspslkpeKKVAEAEKKVEEAKKKAKDqkEEDRRNYPTNTYKTLELEIAESDVKVKEAELELVKEEA 362

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 119586555  967 EKHATENKVKNLTEEMAGLDEIIAKLTK----EKKALQEAHQQAlddlqAEEDKV 1017
Cdd:NF033838  363 KEPRNEEKIKQAKAKVESKKAEATRLEKiktdRKKAEEEAKRKA-----AEEDKV 412
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
841-1098 3.45e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 41.82  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920
Cdd:COG1340     2 KTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  921 EMNERLedeEEMNAELTAKKRKLeDECSELKRDIDDLELTLAKVEKEKhatENKVKNLTEEMAGLDEiIAKLTKEKKALQ 1000
Cdd:COG1340    82 ELNEKL---NELREELDELRKEL-AELNKAGGSIDKLRKEIERLEWRQ---QTEVLSPEEEKELVEK-IKELEKELEKAK 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1001 EAHQQ------ALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQ 1074
Cdd:COG1340   154 KALEKneklkeLRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEII 233

                         250       260
                  ....*....|....*....|....
gi 119586555 1075 QLDERLKKKDFELNALNARIEDEQ 1098
Cdd:COG1340   234 ELQKELRELRKELKKLRKKQRALK 257
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1276-1796 3.47e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.63  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1276 SQRAKLQTENGELSRQLDEKEALI--SQLTRGKLTYTQQLEDLKRQLEEEvkAKNALAHALQSARHDCDLLREQyeeETE 1353
Cdd:COG3096   215 SLRDYLLPENSGVRKAFQDMEAALreNRMTLEAIRVTQSDRDLFKHLITE--ATNYVAADYMRHANERRELSER---ALE 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1354 AKAELQRVLSKANSEvaQWRTKYETDAIqrtEELEEAKKKLAQRLQEAEEAVEAVnakcssleKTKHRLQNEIEDLMVDV 1433
Cdd:COG3096   290 LRRELFGARRQLAEE--QYRLVEMAREL---EELSARESDLEQDYQAASDHLNLV--------QTALRQQEKIERYQEDL 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1434 ErsnAAAAALDKKQrnfdKILAEWKQKYEESQSELESSQKEARSLSTELFKlknaYEESLEHLETfkrenKNLQEEisdl 1513
Cdd:COG3096   357 E---ELTERLEEQE----EVVEEAAEQLAEAEARLEAAEEEVDSLKSQLAD----YQQALDVQQT-----RAIQYQ---- 416

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1514 teqlgssgKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEgkilraqlEFNQIKAEIERKLAEKDEemeqAKRNHLR 1593
Cdd:COG3096   417 --------QAVQALEKARALCGLPDLTPENAEDYLAAFRAKEQ--------QATEEVLELEQKLSVADA----ARRQFEK 476

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1594 VVDSLQTSLDAETRSR-----NEALRV---KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAvran 1665
Cdd:COG3096   477 AYELVCKIAGEVERSQawqtaRELLRRyrsQQALAQRLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAA---- 552

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1666 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHsqntslinqkkKMDADLSQLQTEVEEA 1745
Cdd:COG3096   553 EELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARAPAWL-----------AAQDALERLREQSGEA 621

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 119586555 1746 VQECRnaeekakkAITDAamMAEELKKEQDTSA---HLERMKKNMEQTIKDLQH 1796
Cdd:COG3096   622 LADSQ--------EVTAA--MQQLLEREREATVerdELAARKQALESQIERLSQ 665
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
843-1097 3.49e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  843 AEREKEMASMKE---EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIknkiqlEAKV 919
Cdd:COG4913   671 AELEAELERLDAssdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAE------DLAR 744

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  920 KEMNERLED--EEEMNAELTAKKRK-LEDECSELKRDIDDLELTLAKVEKE-KHATENKVKNLTEEMAGLDEIIAKLT-- 993
Cdd:COG4913   745 LELRALLEErfAAALGDAVERELREnLEERIDALRARLNRAEEELERAMRAfNREWPAETADLDADLESLPEYLALLDrl 824

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  994 ----------KEKKALQEAHQQALDDLQAEedkvntLTKAKVKLEQQVDDLEGSLEQ-----EKKVRMDLERAKRKlegD 1058
Cdd:COG4913   825 eedglpeyeeRFKELLNENSIEFVADLLSK------LRRAIREIKERIDPLNDSLKRipfgpGRYLRLEARPRPDP---E 895

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 119586555 1059 LKLTQESIMDLENDKQQLDERLKKKDFE-LNALNARIEDE 1097
Cdd:COG4913   896 VREFRQELRAVTSGASLFDEELSEARFAaLKRLIERLRSE 935
DUF724 pfam05266
Protein of unknown function (DUF724); This family contains several uncharacterized proteins ...
 1646-1755 3.53e-03

Protein of unknown function (DUF724); This family contains several uncharacterized proteins found in Arabidopsis thaliana and other plants. This region is often found associated with Agenet domains and may contain coiled-coil.


Pssm-ID: 428400 [Multi-domain]  Cd Length: 188  Bit Score: 40.72  E-value: 3.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1646 SLQSLLKDT-QIQLDDAVRANDDLKENIAIVE-----------RRNNLL---------QAELEELRAVVEQTERSRKLAE 1704
Cdd:pfam05266   50 SFAGLLEKVkKLQVDDSRSVFESLMESFAELEkhgfdvkapqsRINKLLslkdrqtklLEELKKLEKKIAEEESEKRKLE 129

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 119586555  1705 QELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK 1755
Cdd:pfam05266  130 EEIDELEKKILELERQLALAKEKKEAADKEIARLKSEAEKLEQEIQDVELE 180
growth_prot_Scy NF041483
polarized growth protein Scy;
840-1811 3.67e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 42.51  E-value: 3.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  840 LKSAE--REKEMASMKEEFTRL-KEALEKSEARRKELEEKMVSLLQEKNDLQLQVqAEQDNLADAEERCDQLIK------ 910
Cdd:NF041483  296 LASAEsaNEQRTRTAKEEIARLvGEATKEAEALKAEAEQALADARAEAEKLVAEA-AEKARTVAAEDTAAQLAKaartae 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  911 ---NKIQLEAK-----VKEMNERLEDEEEMNAE-LTAKKRKLEDECS-ELKRDIDDLELTLAKVEKEKHATENKVKNLTE 980
Cdd:NF041483  375 evlTKASEDAKattraAAEEAERIRREAEAEADrLRGEAADQAEQLKgAAKDDTKEYRAKTVELQEEARRLRGEAEQLRA 454

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  981 EMAGLDEIIakltkEKKALQEAHQQALDDLQAEEDkvnTLTKAKVkleqQVDDLEGSLEQE-KKVRMD-LERA---KRKL 1055
Cdd:NF041483  455 EAVAEGERI-----RGEARREAVQQIEEAARTAEE---LLTKAKA----DADELRSTATAEsERVRTEaIERAttlRRQA 522

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1056 EGDLKLTQESIMDLENDKQQLDERLKKkDFELNALNARIEDEQALGSQLQKKLKELqARIEELEEE-----LEAERTARA 1130
Cdd:NF041483  523 EETLERTRAEAERLRAEAEEQAEEVRA-AAERAARELREETERAIAARQAEAAEEL-TRLHTEAEErltaaEEALADARA 600

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1131 KVEKLRSDLSRELEEIseRLEEAGGATSVQiemnKKREAEFQKMRR----DLEEATLQHEATAAALRKKHADSVAEL-GE 1205
Cdd:NF041483  601 EAERIRREAAEETERL--RTEAAERIRTLQ----AQAEQEAERLRTeaaaDASAARAEGENVAVRLRSEAAAEAERLkSE 674

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1206 QIDNLQRVKqklekekSEFKLELDDVTSNMEQIIKAKAANLEKMCRTLEDQMNEHRSKAEETQRSVND-----LTSQRAK 1280
Cdd:NF041483  675 AQESADRVR-------AEAAAAAERVGTEAAEALAAAQEEAARRRREAEETLGSARAEADQERERAREqseelLASARKR 747

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1281 LQTENGELSRQLDEKEALISQLTRGKLTYTQQLED----LKRQLEEEVKA-KNALAHALQSARhdcdllreqyeeeTEAK 1355
Cdd:NF041483  748 VEEAQAEAQRLVEEADRRATELVSAAEQTAQQVRDsvagLQEQAEEEIAGlRSAAEHAAERTR-------------TEAQ 814

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1356 AELQRVLSKANSEvaqwRTKYETDAI---QRTEELEEAKKKLAQR-LQEAEEAVEAVNAKCSSLEKtkhRLQNEIEDLMV 1431
Cdd:NF041483  815 EEADRVRSDAYAE----RERASEDANrlrREAQEETEAAKALAERtVSEAIAEAERLRSDASEYAQ---RVRTEASDTLA 887

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1432 DVERSNAAAAALDKKQRNfdKILAEwkqkyeeSQSELESSQKEARSLSTELFKLKNAYEESLehLETFKRENKNLQEEIS 1511
Cdd:NF041483  888 SAEQDAARTRADAREDAN--RIRSD-------AAAQADRLIGEATSEAERLTAEARAEAERL--RDEARAEAERVRADAA 956

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1512 DLTEQLGSsgKTIHELEKVRK---------QLEAEKMELQSALEEAEASLEHEEgkiLRAQlefnqIKAEIERKLAEKDE 1582
Cdd:NF041483  957 AQAEQLIA--EATGEAERLRAeaaetvgsaQQHAERIRTEAERVKAEAAAEAER---LRTE-----AREEADRTLDEARK 1026

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1583 EMEQAKRNHLRVVDSLQTSLDAE-----TRSRNEALRVKKKMEGDLNEM-EIQLSHANRMAAEAQKQVKSLQSLLKDTQI 1656
Cdd:NF041483 1027 DANKRRSEAAEQADTLITEAAAEadqltAKAQEEALRTTTEAEAQADTMvGAARKEAERIVAEATVEGNSLVEKARTDAD 1106

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1657 QLDDAVRanddlKENIAIVERRNNL---LQAELEEL--RAVVEQTERSR----------KLAEQELIETSERVQLLHSQN 1721
Cdd:NF041483 1107 ELLVGAR-----RDATAIRERAEELrdrITGEIEELheRARRESAEQMKsagercdalvKAAEEQLAEAEAKAKELVSDA 1181

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1722 TS-----LINQKKKMDADLSQLQTEVEEAVQEcrnAEEKAKKAITDAAMMAEELKKEQDTsahLERMKKNMEQTIKDLQH 1796
Cdd:NF041483 1182 NSeaskvRIAAVKKAEGLLKEAEQKKAELVRE---AEKIKAEAEAEAKRTVEEGKRELDV---LVRRREDINAEISRVQD 1255

                        1050
                  ....*....|....*
gi 119586555 1797 RLDEAEQIALKGGKK 1811
Cdd:NF041483 1256 VLEALESFEAPSGGG 1270
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1772-1924 4.02e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 42.04  E-value: 4.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1772 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGK------KQLQKLEARVRELENELEAEQKRNAESVKGMRKSE 1845
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRqldresDRNQELQKRIRLLEKREAEAEEALREQAELNRLKK 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119586555  1846 RRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1924
Cdd:pfam05557   83 KYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQ 161
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1789-1928 4.03e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 4.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1789 QTIKDLQHRLDEAEQIA--LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1866
Cdd:COG1579     7 RALLDLQELDSELDRLEhrLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVR 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119586555 1867 DL--VDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1928
Cdd:COG1579    87 NNkeYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEE 150
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1255-1448 4.14e-03

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 42.51  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1255 DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEkealISQlTRGKLTYTQQledlkrqleeevkakNALAHAL 1334
Cdd:NF012221 1545 DAVSKHAKQDDAAQNALADKERAEADRQRLEQEKQQQLAA----ISG-SQSQLESTDQ---------------NALETNG 1604

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1335 QSARhdcDLLREQYEEETEAKAELQRVLSKANSEVA-------QWRTKYET---DAIQR---------TEELEEAKKKLA 1395
Cdd:NF012221 1605 QAQR---DAILEESRAVTKELTTLAQGLDALDSQATyagesgdQWRNPFAGgllDRVQEqlddakkisGKQLADAKQRHV 1681

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 119586555 1396 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNaaAAALDKKQR 1448
Cdd:NF012221 1682 DNQQKVKDAVAKSEAGVAQGEQNQANAEQDIDDAKADAEKRK--DDALAKQNE 1732
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 950-1111 4.35e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 40.66  E-value: 4.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   950 LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAlQEAHQQALDDLQAeedKVNTLTKAKVKLEQ 1029
Cdd:pfam13851   31 LKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLEN-YEKDKQSLKNLKA---RLKVLEKELKDLKW 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1030 QVDDLEgslEQEKKVRMDLERAKRKLEGDLKLTQESI----MDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQ 1105
Cdd:pfam13851  107 EHEVLE---QRFEKVERERDELYDKFEAAIQDVQQKTglknLLLEKKLQALGETLEKKEAQLNEVLAAANLDPDALQAVT 183


                   ....*.
gi 119586555  1106 KKLKEL 1111
Cdd:pfam13851  184 EKLEDV 189
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
843-1151 4.42e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.43  E-value: 4.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEM 922
Cdd:COG4372    27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  923 NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE------K 996
Cdd:COG4372   107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAeaeqalD 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  997 KALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076
Cdd:COG4372   187 ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELA 266

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119586555 1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151
Cdd:COG4372   267 ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELAD 341
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1792-1932 4.43e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1792 KDLQHRLDEAEQIALKggkKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDK 1871
Cdd:COG1196   216 RELKEELKELEAELLL---LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555 1872 LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKR 1932
Cdd:COG1196   293 LLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEEL 353
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1526-1797 4.45e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 4.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1526 ELEKVRkqLEAEKMELQSALEEaEASLEHEEGKIL-RAQLEFNQ----IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1600
Cdd:pfam17380  349 ELERIR--QEERKRELERIRQE-EIAMEISRMRELeRLQMERQQknerVRQELEAARKVKILEEERQRKIQQQKVEMEQI 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1601 SLDAETRSRNEALRVKKKMEgdlNEMEiqlshanRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNN 1680
Cdd:pfam17380  426 RAEQEEARQREVRRLEEERA---REME-------RVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRK 495

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1681 LLQAELEELRAVVEQTERSRKLAEQELIEtservqllhSQNTSLINQKKKMDADLSQLQTEVEEavqecrnaeekaKKAI 1760
Cdd:pfam17380  496 ILEKELEERKQAMIEEERKRKLLEKEMEE---------RQKAIYEEERRREAEEERRKQQEMEE------------RRRI 554

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 119586555  1761 TDAAMMAEELKKEQDTsahLERMKKNMEQTIKDLQHR 1797
Cdd:pfam17380  555 QEQMRKATEERSRLEA---MEREREMMRQIVESEKAR 588
46 PHA02562
endonuclease subunit; Provisional
 1484-1663 4.58e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.92  E-value: 4.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1484 KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ----------------SALEE 1547
Cdd:PHA02562  217 RKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmyekggvcptctQQISE 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1548 AEASLEHEEGKILRAQLEFNQIKAEIErKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEgdlnemE 1627
Cdd:PHA02562  297 GPDRITKIKDKLKELQHSLEKLDTAID-ELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIE------E 369

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 119586555 1628 IQLSHANRmaaeaQKQVKSLQSLLKDTQIQLDDAVR 1663
Cdd:PHA02562  370 LQAEFVDN-----AEELAKLQDELDKIVKTKSELVK 400
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1433-1706 4.69e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 41.87  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1433 VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARslstelFKLKNAYEESLEHLETfkrENKNLQEEISD 1512
Cdd:COG5185   277 SKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAA------AEAEQELEESKRETET---GIQNLTAEIEQ 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1513 LTEQLGSSGKTIHElekvrkqlEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL 1592
Cdd:COG5185   348 GQESLTENLEAIKE--------EIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDTLKAAD 419

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1593 RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEiQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 1672
Cdd:COG5185   420 RQIEELQRQIEQATSSNEEVSKLLNELISELNKVM-READEESQSRLEEAYDEINRSVRSKKEDLNEELTQIESRVSTLK 498

                         250       260       270
                  ....*....|....*....|....*....|....
gi 119586555 1673 AIVERRNNLLQAELEELRAVVEQTERSRKLAEQE 1706
Cdd:COG5185   499 ATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRA 532
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 841-1105 4.96e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.13  E-value: 4.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND--LQLQVQAEQDNLADAEERCDQLIKNKIQLEAK 918
Cdd:pfam12128  662 KQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEqkREARTEKQAYWQVVEGALDAQLALLKAAIAAR 741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   919 VKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHA-------------------------TEN 973
Cdd:pfam12128  742 RSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEvlryfdwyqetwlqrrprlatqlsnIER 821

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   974 KVKNLTEEMAGLDE----IIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLtkAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049
Cdd:pfam12128  822 AISELQQQLARLIAdtklRRAKLEMERKASEKQQVRLSENLRGLRCEMSKL--ATLKEDANSEQAQGSIGERLAQLEDLK 899

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555  1050 RAKRKLEGDLKLTQESIMDLENDKQQLD-----ERLKKKDFELNALNARIEDEQALGSQLQ 1105
Cdd:pfam12128  900 LKRDYLSESVKKYVEHFKNVIADHSGSGlaetwESLREEDHYQNDKGIRLLDYRKLVPYLE 960
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1397-1590 5.05e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1397 RLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKyeesqselessqkeAR 1476
Cdd:COG1579    11 DLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEAR--------------IK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1477 SLSTELFKLKNAYE-ESLEH-LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEh 1554
Cdd:COG1579    77 KYEEQLGNVRNNKEyEALQKeIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELE- 155

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 119586555 1555 EEGKILRAQLEfnQIKAEIERKLAEKDEEMEQAKRN 1590
Cdd:COG1579   156 AELEELEAERE--ELAAKIPPELLALYERIRKRKNG 189
IFT57 pfam10498
Intra-flagellar transport protein 57; Eukaryotic cilia and flagella are specialized organelles ...
 896-1166 5.13e-03

Intra-flagellar transport protein 57; Eukaryotic cilia and flagella are specialized organelles found at the periphery of cells of diverse organizms. Intra-flagellar transport (IFT) is required for the assembly and maintenance of eukaryotic cilia and flagella, and consists of the bidirectional movement of large protein particles between the base and the distal tip of the organelle. IFT particles contain multiple copies of two distinct protein complexes, A and B, which contain at least 6 and 11 protein subunits. IFT57 is part of complex B but is not, however, required for the core subunits to stay associated. This protein is known as Huntington-interacting protein-1 in humans.


Pssm-ID: 463118 [Multi-domain]  Cd Length: 360  Bit Score: 41.48  E-value: 5.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   896 DNLADAEercdqLIKNKIQLEAKVKEMNERLEDEEEMnaeltakkrkledecselkrDIDDLELTLAKVEKEKHATENKV 975
Cdd:pfam10498  107 DDLADEA-----LKRKNFKWKKPKYPPEEEFEEEDVV--------------------EEDDAELTLEKVEEEMLIEGDDF 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   976 KNLTEEmaglDEIIAKLTKEKKALQEAHQQALD------DLQAEEDKVntLTKAKVKLEQQVDDLEGSLEQ----EKKVR 1045
Cdd:pfam10498  162 KEDDED----EDLYNESTKGEEAESSKPREIIEsnvdaaEWKLELERV--LPQLKVTIKADAKDWRAHLEQmkqhKKSIE 235

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1046 MDLERAK---RKLEGDLKLTQESIMDLE---NdkQQLDERLKkkdfELNALNARIedeqalgSQLQKKLKELQARIeele 1119
Cdd:pfam10498  236 ESLPDTKsqlDKLHTDISKTLEKIESREkyiN--SQLEPLIQ----EYREAQDEL-------SEVQEKYKQLSEGV---- 298

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 119586555  1120 eeleaertarakveklrSDLSRELEEISERLEeaggatSVQIEMNKK 1166
Cdd:pfam10498  299 -----------------TERTRELAEITEELE------KVKQEMEER 322
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1759-1932 5.56e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1759 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELENELEAEQKRNAESV 1838
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQA-ELEALQAEIDKLQAEIAEAEAEIEERREELGERA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1839 KGMRKSERRIKELT-----YQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1913
Cdd:COG3883    93 RALYRSGGSVSYLDvllgsESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172

                         170
                  ....*....|....*....
gi 119586555 1914 AESQVNKLRAKSRDIGTKR 1932
Cdd:COG3883   173 LEAQQAEQEALLAQLSAEE 191
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 846-989 5.62e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.16  E-value: 5.62e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555    846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQleaKVKEMNER 925
Cdd:smart00787  157 KEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCDPTELDRAKEKLKKLLQEIMIKVK---KLEELEEE 233

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119586555    926 LEDEEEMNAELTAKKRKLEDECSELKR-----------DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989
Cdd:smart00787  234 LQELESKIEDLTNKKSELNTEIAEAEKkleqcrgftfkEIEKLKEQLKLLQSLTGWKITKLSGNTLSMTYDREIN 308
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
924-1152 5.80e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 41.05  E-value: 5.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  924 ERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL----DEIIAKLTKEKKAL 999
Cdd:COG1340     1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELrekrDELNEKVKELKEER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1000 QEAHQQA------LDDLQAEEDKVNTLTKAKVKLEQQVDDLEG-------SLEQEKKVRMDLERAKRKLEgdlklTQESI 1066
Cdd:COG1340    81 DELNEKLnelreeLDELRKELAELNKAGGSIDKLRKEIERLEWrqqtevlSPEEEKELVEKIKELEKELE-----KAKKA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1067 MDLENDKQQLDERLKKKDFELNALNARIedeQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1146
Cdd:COG1340   156 LEKNEKLKELRAELKELRKEAEEIHKKI---KELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEI 232


                  ....*.
gi 119586555 1147 SERLEE 1152
Cdd:COG1340   233 IELQKE 238
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 864-1001 6.10e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 40.82  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  864 EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDqliKNKIQLEAKVKEMNERLEDEEEMN-----AELTA 938
Cdd:cd22656   110 EELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTE---KDQTALETLEKALKDLLTDEGGAIarkeiKDLQK 186

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119586555  939 KKRKLEDEC-SELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1001
Cdd:cd22656   187 ELEKLNEEYaAKLKAKIDELKALIADDEAKLAAALRLIADLTAADTDLDNLLALIGPAIPALEK 250
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1369-1508 6.42e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.35  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1369 VAQWRTKYETDA------IQRTEELEeakKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERsnAAAAA 1442
Cdd:PRK00409  504 IEEAKKLIGEDKeklnelIASLEELE---RELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEK--EAQQA 578

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119586555 1443 LDKKQRNFDKILAEWKQKYEESQSELES-SQKEARSlstelfKLKNAYEESLEHLETFKRENKNLQE 1508
Cdd:PRK00409  579 IKEAKKEADEIIKELRQLQKGGYASVKAhELIEARK------RLNKANEKKEKKKKKQKEKQEELKV 639
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 839-1152 6.59e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 41.48  E-value: 6.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  839 LLKSAEREKEMASMKEEFTRLKEALEKSE----ARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDqlIKNKIQ 914
Cdd:COG5185   235 LKGFQDPESELEDLAQTSDKLEKLVEQNTdlrlEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSID--IKKATE 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  915 LEAKVKEmnerledEEEMNAELTAKKRKLEdecSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAgLDEIIAKLTK 994
Cdd:COG5185   313 SLEEQLA-------AAEAEQELEESKRETE---TGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVE-LSKSSEELDS 381

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  995 EKKALQEAHQqalddlQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLE-NDK 1073
Cdd:COG5185   382 FKDTIESTKE------SLDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISELNkVMR 455

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119586555 1074 QQLDERLKKKDFELNALNARIEDEQAlgsQLQKKLKELQARIeeleeeleaeRTARAKVEKLRSDLSRELEEISERLEE 1152
Cdd:COG5185   456 EADEESQSRLEEAYDEINRSVRSKKE---DLNEELTQIESRV----------STLKATLEKLRAKLERQLEGVRSKLDQ 521
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1100-1430 6.69e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.42  E-value: 6.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1100 LGSQLQKKLKEL-------QARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Cdd:pfam07888   32 LQNRLEECLQERaellqaqEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQID---NLQRVKQKLEKEKSEFKLELDDVTSnmeqiIKAKAANLEKM 1249
Cdd:pfam07888  112 ELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLEretELERMKERAKKAGAQRKEEEAERKQ-----LQAKLQQTEEE 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1250 CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQL--TRGKLTYTQQ-LEDLKRQLEEEVKA 1326
Cdd:pfam07888  187 LRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELrsLQERLNASERkVEGLGEELSSMAAQ 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1327 KNALAHALQSARHDCDLLREQYEE------ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE-------------EL 1387
Cdd:pfam07888  267 RDRTQAELHQARLQAAQLTLQLADaslalrEGRARWAQERETLQQSAEADKDRIEKLSAELQRLEerlqeermereklEV 346

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 119586555  1388 EEAKKKLAQRLQEAEEAVEAVNAKCS--SLEKTKHRLQNEIEDLM 1430
Cdd:pfam07888  347 ELGREKDCNRVQLSESRRELQELKASlrVAQKEKEQLQAEKQELL 391
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
844-1152 6.75e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMN 923
Cdd:COG4372    56 QAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLE 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  924 ERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE-----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 998
Cdd:COG4372   136 AQIAELQSEIAEREEELKELEEQLESLQEELAALEqelqaLSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRE 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  999 LQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDE 1078
Cdd:COG4372   216 LAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALEL 295

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119586555 1079 RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE 1152
Cdd:COG4372   296 KLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVAD 369
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 835-1112 6.76e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 41.48  E-value: 6.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNdlQLQVQAEQDNLADAEERCDQLIKNKIQ 914
Cdd:COG5185   266 RLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEE--QLAAAEAEQELEESKRETETGIQNLTA 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  915 --------LEAKVKEMNERLE--DEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENK-VKNLTEEMA 983
Cdd:COG5185   344 eieqgqesLTENLEAIKEEIEniVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDtLKAADRQIE 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  984 GLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRmDLERAKRKLEGDLKLTQ 1063
Cdd:COG5185   424 ELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINRSVRSKKEDLNE-ELTQIESRVSTLKATLE 502

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 119586555 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
Cdd:COG5185   503 KLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILALENLIPASELI 551
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 835-1083 6.78e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 40.95  E-value: 6.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAeERCDQLIKNKIQ 914
Cdd:pfam15905   68 NLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQLLEL-TRVNELLKAKFS 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   915 LEAKVKEMN----ERLEDEEEMNA---ELTAKKRKLEDECSELKRD-------IDDLELTLAKVEKEKHATENKVKNLTE 980
Cdd:pfam15905  147 EDGTQKKMSslsmELMKLRNKLEAkmkEVMAKQEGMEGKLQVTQKNlehskgkVAQLEEKLVSTEKEKIEEKSETEKLLE 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555   981 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Cdd:pfam15905  227 YITELSCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELLREYEEKEQTLN 306

                          250       260
                   ....*....|....*....|...
gi 119586555  1061 LTQESIMDLENDKQQLDERLKKK 1083
Cdd:pfam15905  307 AELEELKEKLTLEEQEHQKLQQK 329
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1104-1797 7.43e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 41.35  E-value: 7.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1104 LQKKLKELQarieelEEELEAERTARAKVEKLRSDL-------SRELEEISERLEEAGGATSVQIEMNKKREAEFQKM-- 1174
Cdd:pfam10174    1 LQAQLRDLQ------RENELLRRELDIKESKLGSSMnsiktfwSPELKKERALRKEEAARISVLKEQYRVTQEENQHLql 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1175 -----------RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME---QIIK 1240
Cdd:pfam10174   75 tiqalqdelraQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHERQAKELFLLRKTLEEMELRIEtqkQTLG 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1241 AKAANLEKMCRTLedQMNEHRSKAEEtqrSVNDLTSQRAKLQTENGELSRQLDEKEALISQLtRGKLTYTQQLED---LK 1317
Cdd:pfam10174  155 ARDESIKKLLEML--QSKGLPKKSGE---EDWERTRRIAEAEMQLGHLEVLLDQKEKENIHL-REELHRRNQLQPdpaKT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1318 RQLEEEVKAKNA-----------LAHALQSARHDCDLLREQYEEETEAKA--------------ELQRVLSKANSEVAQW 1372
Cdd:pfam10174  229 KALQTVIEMKDTkisslernirdLEDEVQMLKTNGLLHTEDREEEIKQMEvykshskfmknkidQLKQELSKKESELLAL 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1373 RTKYETDAIQRTEEleeakkklaqrLQEAEEAVEAVNAKcsslEKTKHRLQNEIEDLMVDversnaaaaaLDKKQRNFDK 1452
Cdd:pfam10174  309 QTKLETLTNQNSDC-----------KQHIEVLKESLTAK----EQRAAILQTEVDALRLR----------LEEKESFLNK 363

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1453 ilaewKQKYeesqseLESSQKEARSLSTELFKLKNAyeeslehLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1532
Cdd:pfam10174  364 -----KTKQ------LQDLTEEKSTLAGEIRDLKDM-------LDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVK 425

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1533 QLEAEKMELQSALEEAEASLEHEEGKILRaqlefnqIKAEIERKLAEKDEEMEQAKR---NHLRVVDSLQTSLDAETRSR 1609
Cdd:pfam10174  426 SLQTDSSNTDTALTTLEEALSEKERIIER-------LKEQREREDRERLEELESLKKenkDLKEKVSALQPELTEKESSL 498

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1610 NEalrVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK---SLQSLLKDTQiQLDDAVRANDDLKENIAIVERR-------N 1679
Cdd:pfam10174  499 ID---LKEHASSLASSGLKKDSKLKSLEIAVEQKKEecsKLENQLKKAH-NAEEAVRTNPEINDRIRLLEQEvarykeeS 574

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  1680 NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLH-SQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKK 1758
Cdd:pfam10174  575 GKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMkEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQ 654

                          730       740       750
                   ....*....|....*....|....*....|....*....
gi 119586555  1759 AITDAAMMAEELKKEQdtsahLERMKKNMEQTIKDLQHR 1797
Cdd:pfam10174  655 LQLEELMGALEKTRQE-----LDATKARLSSTQQSLAEK 688
growth_prot_Scy NF041483
polarized growth protein Scy;
1353-1857 7.71e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 41.35  E-value: 7.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1353 EAKAELQRVLSKANSEVAQWRTKYETDAIQRTeelEEAKKKLAQRLQEAEEAVEAVNAKCsslEKTKHRLQNEIEDLMVD 1432
Cdd:NF041483  276 EARAEAEKVVAEAKEAAAKQLASAESANEQRT---RTAKEEIARLVGEATKEAEALKAEA---EQALADARAEAEKLVAE 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1433 VE---RSNAA---AAALDKKQRNFDKILAEwkqkyeesqselesSQKEARSLStelfklKNAYEESLEHLETFKRENKNL 1506
Cdd:NF041483  350 AAekaRTVAAedtAAQLAKAARTAEEVLTK--------------ASEDAKATT------RAAAEEAERIRREAEAEADRL 409

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1507 QEEISDLTEQLGSSGKtiheleKVRKQLEAEKMELQSaleeaEASLEHEEGKILRAQL--EFNQIKAEIERKLAEKDEEM 1584
Cdd:NF041483  410 RGEAADQAEQLKGAAK------DDTKEYRAKTVELQE-----EARRLRGEAEQLRAEAvaEGERIRGEARREAVQQIEEA 478

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1585 EQAKRNHLRV----VDSLQTSLDAET-RSRNEALRVKKKMEGDLNE-MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1658
Cdd:NF041483  479 ARTAEELLTKakadADELRSTATAESeRVRTEAIERATTLRRQAEEtLERTRAEAERLRAEAEEQAEEVRAAAERAAREL 558

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1659 -DDAVRANDDLKENIAIVERRnnlLQAELEELRAVVEQT--------ERSRKLAEQEL----IETSERVQLLHSQntsli 1725
Cdd:NF041483  559 rEETERAIAARQAEAAEELTR---LHTEAEERLTAAEEAladaraeaERIRREAAEETerlrTEAAERIRTLQAQ----- 630

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1726 nqkkkMDADLSQLQTE-VEEAVQECRNAEEKAKKAITDAAMMAEELKKE-QDTS--------AHLERMKKNMEQTIKDLQ 1795
Cdd:NF041483  631 -----AEQEAERLRTEaAADASAARAEGENVAVRLRSEAAAEAERLKSEaQESAdrvraeaaAAAERVGTEAAEALAAAQ 705

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119586555 1796 H----RLDEAEQIaLKGGKKQLQKLEARVRELENELEAEQKR-----NAESVKGMRKSERRIKELTYQTEE 1857
Cdd:NF041483  706 EeaarRRREAEET-LGSARAEADQERERAREQSEELLASARKrveeaQAEAQRLVEEADRRATELVSAAEQ 775
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 949-1863 7.73e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 41.48  E-value: 7.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  949 ELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAgldeiiaKLTKEKKALQEAHQQALDDLQaeedKVNTLTKAKVKLE 1028
Cdd:COG3096   282 ELSERALELRRELFGARRQLAEEQYRLVEMARELE-------ELSARESDLEQDYQAASDHLN----LVQTALRQQEKIE 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1029 QQVDDLEG---SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN---DKQQ-LDERLKKKDFELNALNARIEDEQALG 1101
Cdd:COG3096   351 RYQEDLEElteRLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSqlaDYQQaLDVQQTRAIQYQQAVQALEKARALCG 430

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1102 ------SQLQKKLKELQARieeLEEELEAERTARAKVEkLRSDLSRELEEISERLEEAGGATSvqiemnkkREAEFQKMR 1175
Cdd:COG3096   431 lpdltpENAEDYLAAFRAK---EQQATEEVLELEQKLS-VADAARRQFEKAYELVCKIAGEVE--------RSQAWQTAR 498

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1176 RDLEEA-TLQHEA-TAAALRKKHAdsvaELGEQIDNLQRVKQKLEKEKSEFKLELDDVTsnmeqiikakaanlekmcrTL 1253
Cdd:COG3096   499 ELLRRYrSQQALAqRLQQLRAQLA----ELEQRLRQQQNAERLLEEFCQRIGQQLDAAE-------------------EL 555

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1254 EDQMNEHRSKAEETQRSVNDLTSQRAklqtengELSRQLDEKEALISQLTRGK---LTYTQQLEDLKRQLEEEVKAKNAL 1330
Cdd:COG3096   556 EELLAELEAQLEELEEQAAEAVEQRS-------ELRQQLEQLRARIKELAARApawLAAQDALERLREQSGEALADSQEV 628

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1331 AHALQsarhdcdllrEQYEEETEAKAELQRVLskansevaqwrtkyetdaiQRTEELEEAKKKLAQ-------RLQEAEE 1403
Cdd:COG3096   629 TAAMQ----------QLLEREREATVERDELA-------------------ARKQALESQIERLSQpggaedpRLLALAE 679

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1404 AVEAVnakcsslektkhrLQNEI-EDLMVD-----------------VERSNAAAAALDKK----------QRN---FDK 1452
Cdd:COG3096   680 RLGGV-------------LLSEIyDDVTLEdapyfsalygparhaivVPDLSAVKEQLAGLedcpedlyliEGDpdsFDD 746

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1453 ILAEWKQkyEESQSELESSQKEAR-SLSTELFKLKNAYEEslEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEK-V 1530
Cdd:COG3096   747 SVFDAEE--LEDAVVVKLSDRQWRySRFPEVPLFGRAARE--KRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQfV 822

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1531 RKQL--------EAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE--RKLAE-----KDEEMEQakrnhlRVV 1595
Cdd:COG3096   823 GGHLavafapdpEAELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQllNKLLPqanllADETLAD------RLE 896

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1596 DslqtsLDAETRSRNEALRVKKKMEGDLNEMEIQLShANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLkeniaiV 1675
Cdd:COG3096   897 E-----LREELDAAQEAQAFIQQHGKALAQLEPLVA-VLQSDPEQFEQLQADYLQAKEQQRRLKQQIFALSEV------V 964

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1676 ERRNNLLQAE----LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLiNQKkkmdadLSQLQTEVEEAVQECRN 1751
Cdd:COG3096   965 QRRPHFSYEDavglLGENSDLNEKLRARLEQAEEARREAREQLRQAQAQYSQY-NQV------LASLKSSRDAKQQTLQE 1037

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1752 AEEKAK----KAITDAAMMAEELKKEQDTSAHLERMKKNmeQTIKDLQHRldEAEQIALkggKKQLQKLEARVRELENEL 1827
Cdd:COG3096  1038 LEQELEelgvQADAEAEERARIRRDELHEELSQNRSRRS--QLEKQLTRC--EAEMDSL---QKRLRKAERDYKQEREQV 1110

                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|
gi 119586555 1828 EAEQKRNAESVKGMRKS--ERRI--KELTYQTEEDRKNLL 1863
Cdd:COG3096  1111 VQAKAGWCAVLRLARDNdvERRLhrRELAYLSADELRSMS 1150
PRK12704 PRK12704
phosphodiesterase; Provisional
 1529-1653 7.81e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.92  E-value: 7.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1529 KVRKQLEAEKMELQSALEEAEASLE-HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR 1607
Cdd:PRK12704   28 IAEAKIKEAEEEAKRILEEAKKEAEaIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEK 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 119586555 1608 SRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1653
Cdd:PRK12704  108 REEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAE 153
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
1525-1794 7.83e-03

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 41.21  E-value: 7.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1525 HELEKVRKQLEaekmELQSALEEAEASLEheegkILRAQLEfnqikaEIErKLAEKDEEMEQ--AKRNHLRVVDSLQTSL 1602
Cdd:COG0497   165 RAWRALKKELE----ELRADEAERARELD-----LLRFQLE------ELE-AAALQPGEEEEleEERRRLSNAEKLREAL 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1603 daetrsrNEALRVkkkmegdLNEMEI----QLSHANRM---AAEAQKQVKSLQSLLKDTQIQLDDAVRanddlkeniaiv 1675
Cdd:COG0497   229 -------QEALEA-------LSGGEGgaldLLGQALRAlerLAEYDPSLAELAERLESALIELEEAAS------------ 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1676 errnnllqaeleELRAVVEQTErsrkLAEQELIETSERVQLLHS-------QNTSLINQKKKMDADLSQLQtEVEEAVQE 1748
Cdd:COG0497   283 ------------ELRRYLDSLE----FDPERLEEVEERLALLRRlarkygvTVEELLAYAEELRAELAELE-NSDERLEE 345

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 119586555 1749 CRNAEEKAKKAITDAammAEEL-KKEQDTSAHLErmkKNMEQTIKDL 1794
Cdd:COG0497   346 LEAELAEAEAELLEA---AEKLsAARKKAAKKLE---KAVTAELADL 386
PRK00106 PRK00106
ribonuclease Y;
882-1058 8.27e-03

ribonuclease Y;


Pssm-ID: 178867 [Multi-domain]  Cd Length: 535  Bit Score: 41.01  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  882 QEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA---ELTAKKRKLEDECSELKRDIDDLE 958
Cdd:PRK00106   42 QEAVNLRGKAERDAEHIKKTAKRESKALKKELLLEAKEEARKYREEIEQEFKSerqELKQIESRLTERATSLDRKDENLS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  959 LTLAKVEKEKHATENKVKNLTEEmaglDEIIAKLTKEKkalqEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSL 1038
Cdd:PRK00106  122 SKEKTLESKEQSLTDKSKHIDER----EEQVEKLEEQK----KAELERVAALSQAEAREIILAETENKLTHEIATRIREA 193

                         170       180
                  ....*....|....*....|....*.
gi 119586555 1039 EQEKKVRMD------LERAKRKLEGD 1058
Cdd:PRK00106  194 EREVKDRSDkmakdlLAQAMQRLAGE 219
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 953-1066 8.46e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 41.22  E-value: 8.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  953 DIDDLELTLAKVEKEKHATENkvknltEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVD 1032
Cdd:COG0542   412 ELDELERRLEQLEIEKEALKK------EQDEASFERLAELRDELAELEEELEALKARWEAEKELIEEIQELKEELEQRYG 485

                          90       100       110
                  ....*....|....*....|....*....|....
gi 119586555 1033 DLEgSLEQEkkvrmdLERAKRKLEGDLKLTQESI 1066
Cdd:COG0542   486 KIP-ELEKE------LAELEEELAELAPLLREEV 512
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1526-1789 8.84e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.19  E-value: 8.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1526 ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL------EFNQIKAEIERKLAEKDEEMEQAKRNhlRVVDSL- 1598
Cdd:PRK10929   31 ELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQyqqvidNFPKLSAELRQQLNNERDEPRSVPPN--MSTDALe 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1599 ----QTS--LDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSllkdtqiqlddavranddlkENI 1672
Cdd:PRK10929  109 qeilQVSsqLLEKSRQAQQEQDRAREISDSLSQLPQQQTEARRQLNEIERRLQTLGT--------------------PNT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1673 AIVERRNNLLQAELEELRAVVEQTERSRKLA--EQELIETseRVQLLHSQNTSLINQKKKMDADL-SQLQTEVEEAVQec 1749
Cdd:PRK10929  169 PLAQAQLTALQAESAALKALVDELELAQLSAnnRQELARL--RSELAKKRSQQLDAYLQALRNQLnSQRQREAERALE-- 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 119586555 1750 rNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1789
Cdd:PRK10929  245 -STELLAEQSGDLPKSIVAQFKINRELSQALNQQAQRMDL 283
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 879-1041 9.06e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 39.74  E-value: 9.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  879 SLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDE-EEMNAELTAKKRKLED---------ECS 948
Cdd:cd00176    37 ALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRwEELRELAEERRQRLEEaldlqqffrDAD 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  949 ELKRDIDDLELTLAKVEKEKHATE-----NKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQalDDLQAEEDKVNTLTKA 1023
Cdd:cd00176   117 DLEQWLEEKEAALASEDLGKDLESveellKKHKELEEELEAHEPRLKSLNELAEELLEEGHP--DADEEIEEKLEELNER 194

                         170
                  ....*....|....*...
gi 119586555 1024 KVKLEQQVDDLEGSLEQE 1041
Cdd:cd00176   195 WEELLELAEERQKKLEEA 212
F-BAR_PSTPIP2 cd07672
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine ...
 1248-1425 9.16e-03

The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Proline-Serine-Threonine Phosphatase-Interacting Protein 2 (PSTPIP2), also known as Macrophage Actin-associated tYrosine Phosphorylated protein (MAYP), is mostly expressed in hematopoietic cells but is also expressed in the brain. It is involved in regulating cell adhesion and motility. Mutations in the gene encoding murine PSTPIP2 can cause autoinflammatory disorders such as chronic multifocal osteomyelitis and macrophage autoinflammatory disease. PSTPIP2 contains an N-terminal F-BAR domain and lacks the PEST motifs and SH3 domain that are found in PSTPIP1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.


Pssm-ID: 153356 [Multi-domain]  Cd Length: 240  Bit Score: 39.93  E-value: 9.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1248 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE---EEV 1324
Cdd:cd07672    19 KNCKEFEDFLKERASIEEKYGKELLNLSKKKPCGQTEINTLKRSLDVFKQQIDNVGQSHIQLAQTLRDEAKKMEdfrERQ 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1325 KAKNALAHALQSARHDCDLLreQYEEETEAKAEL-QRVLSKANSEVAQWRTKYETDAIQRteelEEAKKKLAQRLQEAEE 1403
Cdd:cd07672    99 KLARKKIELIMDAIHKQRAM--QFKKTMESKKNYeQKCRDKDEAEQAVNRNANLVNVKQQ----EKLFAKLAQSKQNAED 172

                         170       180
                  ....*....|....*....|..
gi 119586555 1404 AVEAVNAKCSSLEKTKHRLQNE 1425
Cdd:cd07672   173 ADRLYMQNISVLDKIREDWQKE 194
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
985-1163 9.56e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.00  E-value: 9.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555  985 LDEIIAKLTKEKkALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSlEQEKKVRMdLERAKRKLEGDLKLTQE 1064
Cdd:COG2433   365 RDEVKARVIRGL-SIEEALEELIEKELPEEEPEAEREKEHEERELTEEEEEIR-RLEEQVER-LEAEVEELEAELEEKDE 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586555 1065 SIMDLEN---DKQQLDERLKKKDFELNALNARIEdeqalgsQLQKKLKELQARIEELEEELEAERTARAK---------- 1131
Cdd:COG2433   442 RIERLERelsEARSEERREIRKDREISRLDREIE-------RLERELEEERERIEELKRKLERLKELWKLehsgelvpvk 514

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 119586555 1132 -VEKLRSDLSRELEE---ISER----LEEAGGATSVQIEM 1163
Cdd:COG2433   515 vVEKFTKEAIRRLEEeygLKEGdvvyLRDASGAGRSTAEL 554
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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