|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
54-692 |
3.96e-165 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 495.76 E-value: 3.96e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVvGVTQPRRVAAVTV-RRVAEERGAVLGHEVG 132
Cdd:COG1643 10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRI-GMLEPRRLAARAAaERMAEELGEPVGETVG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 133 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKK-RGDL 211
Cdd:COG1643 89 YRVRFEDKVSA-ATRIEVVTEGILLRELQRDPELEGV----------DTVIFDEFHERSLNADLLLALLLDLQPAlRPDL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 212 RLIVASATLDADKFRDFFNqnetsdPARdtcvILTVEGRTFPVDIFYL--QSPVPDYIKSTVETVVKIHQtEGDGDVLAF 289
Cdd:COG1643 158 KLLVMSATLDAERFARLLG------DAP----VIESSGRTYPVEVRYRplPADERDLEDAVADAVREALA-EEPGDILVF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 290 LTGQEEvetvvsmlIEQARALARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDC 369
Cdd:COG1643 227 LPGERE--------IRRTAEALRGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDS 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 370 GFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGID 449
Cdd:COG1643 299 GLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLG 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 450 NVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNI 529
Cdd:COG1643 379 DPEDLPFLDPPPARAIADARALLQELGALDADGRLT-PLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDP 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 530 FvvppnqkshairvhRKFAveEGDHLTMLNIYEAFIKHnkdskwcQEHFLNYKGLVRAATVREQLKKLLvkfQVPRKSSE 609
Cdd:COG1643 458 R--------------RGAA--GSDLLARLNLWRRLREQ-------QREFLSYLRLREWRDLARQLRRLL---GEGANEEP 511
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 610 GDPDLVLRCIVSGFFAN-AARFHSTGAYRTIRdDHELHIHPASVLYAEKpprWVIYNEVIQT---SKyyMRDVTAIESAW 685
Cdd:COG1643 512 ADYEAIGLLLALAYPDRiARRRGEGGRYLLAR-GRGAALFPGSPLAKKE---WLVAAELVGGaaeAR--IRLAAPIDPEW 585
|
....*..
gi 119596413 686 LLELAPH 692
Cdd:COG1643 586 LEELAAH 592
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
52-692 |
1.13e-145 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 457.31 E-value: 1.13e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 52 QKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTV-RRVAEERGAVLGHE 130
Cdd:TIGR01967 64 DNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSHG-LIGHTQPRRLAARTVaQRIAEELGTPLGEK 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 131 VGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKRGD 210
Cdd:TIGR01967 143 VGYKVRFHDQVSS-NTLVKLMTDGILLAETQQDRFLSRY----------DTIIIDEAHERSLNIDFLLGYLKQLLPRRPD 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 211 LRLIVASATLDADKFRDFFNQNEtsdpardtcvILTVEGRTFPVDIFY-----LQSPVP-DYIKSTVETVVKIHQtEGDG 284
Cdd:TIGR01967 212 LKIIITSATIDPERFSRHFNNAP----------IIEVSGRTYPVEVRYrplveEQEDDDlDQLEAILDAVDELFA-EGPG 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 285 DVLAFLTGQEEVEtvvsmliEQARALARTGMkRHLRVLPMYAGLPSFEQMKVFErvSRSVRKVIVATNVAETSITISGIV 364
Cdd:TIGR01967 281 DILIFLPGEREIR-------DAAEILRKRNL-RHTEILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIH 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 365 YVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLK 444
Cdd:TIGR01967 351 YVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQML 430
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 445 ALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKD---CRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIA 521
Cdd:TIGR01967 431 ALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDeaePQLT-PIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIA 509
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 522 AMMQIQNIFVVPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEAF------IKHNKDSKWCQEHFLNYKGLVRAATVREQLK 595
Cdd:TIGR01967 510 SALSIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIeeqrqaLSANQFRNACRKQYLNYLRVREWQDIYRQLT 589
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 596 KLLVKFQVPRKSSEGDPDLVLRCIVSGFFANAARFHSTGAYRTIRdDHELHIHPASVLyAEKPPRWVIYNEVIQTSKYYM 675
Cdd:TIGR01967 590 QVVKELGLKLNEEPADYDAIHKALLSGLLSQIGMKDEKHEYDGAR-GRKFHIFPGSPL-FKKPPKWVMAAELVETSKLYA 667
|
650
....*....|....*..
gi 119596413 676 RDVTAIESAWLLELAPH 692
Cdd:TIGR01967 668 RLVAKIEPEWVEPVAGH 684
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
54-692 |
1.32e-138 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 438.72 E-value: 1.32e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTV-RRVAEERGAVLGHEVG 132
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKG-LIGHTQPRRLAARTVaNRIAEELETELGGCVG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 133 YCIRFddcTDQLA--TRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKRGD 210
Cdd:PRK11131 152 YKVRF---NDQVSdnTMVKLMTDGILLAEIQQDRLLMQY----------DTIIIDEAHERSLNIDFILGYLKELLPRRPD 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 211 LRLIVASATLDADKFRDFFNQNEtsdpardtcvILTVEGRTFPVDIFYlqSPV--------PDYIKSTVETVVKIhQTEG 282
Cdd:PRK11131 219 LKVIITSATIDPERFSRHFNNAP----------IIEVSGRTYPVEVRY--RPIveeaddteRDQLQAIFDAVDEL-GREG 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 283 DGDVLAFLTGQEEVEtvvsmliEQARALARTGMkRHLRVLPMYAGLPSFEQMKVFErvSRSVRKVIVATNVAETSITISG 362
Cdd:PRK11131 286 PGDILIFMSGEREIR-------DTADALNKLNL-RHTEILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPG 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 363 IVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQ 442
Cdd:PRK11131 356 IKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQ 435
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 443 LKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDC-----RLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEI 517
Cdd:PRK11131 436 MTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLT-PLGRQLAQLPVDPRLARMVLEAQKHGCVREV 514
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 518 LSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEaFIK-------HNKDSKWCQEHFLNYkglVRaatV 590
Cdd:PRK11131 515 MIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLAFVNLWN-YLQeqqkalsSNQFRRLCRTDYLNY---LR---V 587
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 591 RE------QLKKLLVKFQVPRKSSEGDPDLVLRCIVSGFFA-----NAARFHSTGAyrtiRDDHeLHIHPASVLYaEKPP 659
Cdd:PRK11131 588 REwqdiytQLRQVVKELGIPVNSEPAEYREIHTALLTGLLShigmkDAEKQEYTGA----RNAR-FSIFPGSGLF-KKPP 661
|
650 660 670
....*....|....*....|....*....|...
gi 119596413 660 RWVIYNEVIQTSKYYMRDVTAIESAWLLELAPH 692
Cdd:PRK11131 662 KWVMVAELVETSRLWGRIAARIEPEWIEPLAQH 694
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
54-247 |
1.65e-126 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 372.96 E-value: 1.65e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVR-RVAEERGAVLGHEVG 132
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRVVGCTQPRRVAAVTVAgRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 133 YCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLR 212
Cdd:cd17980 81 YCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKY----------SVIMLDEAHERTLYTDILIGLLKKIQKKRGDLR 150
|
170 180 190
....*....|....*....|....*....|....*
gi 119596413 213 LIVASATLDADKFRDFFNQNETSDPARDTCVILTV 247
Cdd:cd17980 151 LIVASATLDAEKFRDFFNQNETNDPSKDTATILSV 185
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
54-230 |
5.27e-79 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 249.58 E-value: 5.27e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGwTAEGRVVGVTQPRRVAAVTV-RRVAEERGAVLGHEVG 132
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAG-FARGGMIGITQPRRVAAVSVaKRVAEEMGVELGQLVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 133 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKRGD-- 210
Cdd:cd17978 80 YSVRFDDVTSE-ETRIKYMTDGMLLREAIGDPLLSKY----------SVIILDEAHERTVHTDVLFGLVKSAQRRRKEqk 148
|
170 180
....*....|....*....|...
gi 119596413 211 ---LRLIVASATLDADKFRDFFN 230
Cdd:cd17978 149 lspLKVIIMSATLDADLFSEYFN 171
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
71-231 |
2.08e-77 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 244.68 E-value: 2.08e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 71 QTVVIVGETGCGKSTQIPQYLAEAGWTAEGRV-VGVTQPRRVAAVTV-RRVAEERGAVLGHEVGYCIRFDDCTDQlATRI 148
Cdd:cd17917 2 QVVVIVGETGSGKTTQVPQFLLEDGLAKGGKGrIVCTQPRRIAAISVaERVAEERGEKLGEEVGYQIRFESKTSS-KTRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 149 KFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDF 228
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGY----------SHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSY 150
|
...
gi 119596413 229 FNQ 231
Cdd:cd17917 151 FGG 153
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
252-415 |
2.45e-75 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 239.74 E-value: 2.45e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 252 FPVDIFYLQSPV-----------PDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLieqaRALARTGMKRHLR 320
Cdd:cd18791 1 FPVEVYYLEDILellgissekedPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELL----REELLSPDLGKLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 321 VLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRA 400
Cdd:cd18791 77 VLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRA 156
|
170
....*....|....*
gi 119596413 401 GRGGRSRSGKCYRLY 415
Cdd:cd18791 157 GRAGRTRPGKCYRLY 171
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
54-523 |
2.90e-74 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 256.00 E-value: 2.90e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIP-QYLAEAGWTaeGRVVgVTQPRRVAAVTV-RRVAEERGAVLGHEV 131
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGIN--GKII-MLEPRRLAARNVaQRLAEQLGEKPGETV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 132 GYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKyrltesfsliLSVIMLDEAHERTLYTDIAIGLLKKIQKK-RGD 210
Cdd:PRK11664 81 GYRMRAESKVGP-NTRLEVVTEGILTRMIQRDPELSG----------VGLVILDEFHERSLQADLALALLLDVQQGlRDD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 211 LRLIVASATLDADKFRDFFnqnetsdParDTCVILTvEGRTFPVDIFYLQSPVPDYIKSTVETVVKIHQTEGDGDVLAFL 290
Cdd:PRK11664 150 LKLLIMSATLDNDRLQQLL-------P--DAPVIVS-EGRSFPVERRYQPLPAHQRFDEAVARATAELLRQESGSLLLFL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 291 TGQEEVETVVSMLIEQaralartgMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCG 370
Cdd:PRK11664 220 PGVGEIQRVQEQLASR--------VASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSG 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 371 FVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDN 450
Cdd:PRK11664 292 LERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHD 371
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119596413 451 VLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFgcSQEILSIAAM 523
Cdd:PRK11664 372 PAQLSWLDQPPAAALAAAKRLLQQLGALDGQGRLT-ARGRKMAALGNDPRLAAMLVAAKED--DEAALATAAK 441
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
49-229 |
1.00e-72 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 233.14 E-value: 1.00e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 49 QQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVvGVTQPRRVAAVTV-RRVAEERGAVL 127
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKI-GCTQPRRVAAMSVaKRVAEEFGCCL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 128 GHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKK 207
Cdd:cd17971 80 GQEVGYTIRFEDCTSP-ETVIKYMTDGMLLRECLIDPDLSQY----------SVIMLDEAHERTIHTDVLFGLLKKTVQK 148
|
170 180
....*....|....*....|..
gi 119596413 208 RGDLRLIVASATLDADKFRDFF 229
Cdd:cd17971 149 RPDLKLIVTSATLDAVKFSQYF 170
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
45-230 |
3.42e-69 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 224.22 E-value: 3.42e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 45 LSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWT-AEGRVVGVTQPRRVAAVTV-RRVAEE 122
Cdd:cd17973 4 FEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPhQPKKLVACTQPRRVAAMSVaQRVAEE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 123 RGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLK 202
Cdd:cd17973 84 MDVKLGEEVGYSIRFEDCSSA-KTILKYMTDGMLLREAMSDPLLSRY----------SVIILDEAHERTLATDILMGLLK 152
|
170 180
....*....|....*....|....*...
gi 119596413 203 KIQKKRGDLRLIVASATLDADKFRDFFN 230
Cdd:cd17973 153 EVVRRRPDLKLIVMSATLDAGKFQKYFD 180
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
54-231 |
5.51e-68 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 220.45 E-value: 5.51e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTV-RRVAEERGAVLGHEVG 132
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIGCTQPRRVAAMSVaARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 133 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLR 212
Cdd:cd17974 81 YSIRFEDCTSE-KTVLKYMTDGMLLREFLTEPDLASY----------SVMIIDEAHERTLHTDILFGLVKDIARFRPDLK 149
|
170
....*....|....*....
gi 119596413 213 LIVASATLDADKFRDFFNQ 231
Cdd:cd17974 150 LLISSATMDAEKFSAFFDD 168
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
54-229 |
6.25e-63 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 206.93 E-value: 6.25e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTV-RRVAEERGAVLGHEVG 132
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYG-MIGCTQPRRVAAMSVaKRVSEEMGVELGEEVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 133 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLR 212
Cdd:cd17983 80 YAIRFEDCTSE-NTVIKYMTDGILLRESLRDPDLDKY----------SAIIMDEAHERSLNTDVLFGLLREVVARRRDLK 148
|
170
....*....|....*..
gi 119596413 213 LIVASATLDADKFRDFF 229
Cdd:cd17983 149 LIVTSATMDADKFADFF 165
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
54-227 |
1.66e-56 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 190.64 E-value: 1.66e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAE----GRVVGVTQPRRVAAV-TVRRVAEERGaVLG 128
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPesdnPGMIGITQPRRVAAVsMAKRVAEELN-VFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 129 HEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKR 208
Cdd:cd17982 80 KEVSYQIRYDSTVSE-NTKIKFMTDGVLLKEIQTDFLLRKY----------SVIIIDEAHERSVNTDILIGMLSRIVPLR 148
|
170 180
....*....|....*....|....*....
gi 119596413 209 GD----------LRLIVASATLDADKFRD 227
Cdd:cd17982 149 AKlylqdqtvkpLKLVIMSATLRVEDFTE 177
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
54-229 |
2.15e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 178.89 E-value: 2.15e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVvGVTQPRRVAAVTV-RRVAEERGAVLGHEVG 132
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMI-GVTQPRRVAAISVaQRVAEEMKCTLGSKVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 133 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKI--QKKRG- 209
Cdd:cd17984 80 YQVRFDDCSSK-ETAIKYMTDGCLLRHILADPNLTKY----------SVIILDEAHERSLTTDILFGLLKKLfqEKSPNr 148
|
170 180
....*....|....*....|..
gi 119596413 210 --DLRLIVASATLDADKFRDFF 229
Cdd:cd17984 149 keHLKVVVMSATLELAKLSAFF 170
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
54-231 |
1.97e-46 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 162.61 E-value: 1.97e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAegrvVGVTQPRRVAAVTV-RRVAEERGAVLGHEVG 132
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH----IACTQPRRIACISLaKRVAFESLNQYGSKVA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 133 YCIRFDDcTDQLATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLR 212
Cdd:cd17979 77 YQIRFER-TRTLATKLLFLTEGLLLRQIQRDASLPQY----------NVLILDEVHERHLHGDFLLGVLRCLLRLRPDLK 145
|
170
....*....|....*....
gi 119596413 213 LIVASATLDADKFRDFFNQ 231
Cdd:cd17979 146 LILMSATINIELFSGYFEG 164
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
54-230 |
1.30e-44 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 157.62 E-value: 1.30e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTV-RRVAEERGAVLGHEVG 132
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRG-LIGHTQPRRLAARSVaERIAEELKTELGGAVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 133 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLR 212
Cdd:cd17989 80 YKVRFTDQTSD-ETCVKLMTDGILLAETQTDRYLRAY----------DTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLK 148
|
170
....*....|....*...
gi 119596413 213 LIVASATLDADKFRDFFN 230
Cdd:cd17989 149 VIITSATIDAERFSRHFN 166
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
54-230 |
3.15e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 148.45 E-value: 3.15e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYL----AEAGWTAEGRVVgVTQPRRVAAVTV-RRVAEERG--AV 126
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFIlddaIERGKGSSCRIV-CTQPRRISAISVaERVAAERAesCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 127 LGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQK 206
Cdd:cd17981 80 LGNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNV----------SHLVLDEIHERNLQSDVLMGIVKDLLP 149
|
170 180
....*....|....*....|....
gi 119596413 207 KRGDLRLIVASATLDADKFRDFFN 230
Cdd:cd17981 150 FRSDLKVILMSATLNAEKFSDYFN 173
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
54-231 |
9.95e-39 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 141.59 E-value: 9.95e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAE----AGWTAEGRVVGVTQPRRVAAVTVR-RVAEERGAVLG 128
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllNGGTAQKCNIVCTQPRRISAMSLAtRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 129 -----HEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKyrltesfsliLSVIMLDEAHERTLYTDIAIGLLKK 203
Cdd:cd17975 81 pggknSLCGYQIRMESRTGE-ATRLLYCTTGVLLRKLQEDGLLSS----------ISHIIVDEVHERSVQSDFLLIILKE 149
|
170 180
....*....|....*....|....*...
gi 119596413 204 IQKKRGDLRLIVASATLDADKFRDFFNQ 231
Cdd:cd17975 150 ILHKRSDLHLILMSATVDCEKFSSYFTH 177
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
54-230 |
3.57e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 139.59 E-value: 3.57e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGW-TAEGRVVGV--TQPRRVAAVTV-RRVAEERGAVLGH 129
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLqGPPLPVANIicTQPRRISAISVaERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 130 EVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKyrltesfsliLSVIMLDEAHERTLYTDIAIGLLKKIQKKRG 209
Cdd:cd17985 81 SVGYQIRLESVKSS-ATRLLYCTTGVLLRRLEGDPTLQG----------VTHVIVDEVHERTEESDFLLLVLKDLMVQRP 149
|
170 180
....*....|....*....|.
gi 119596413 210 DLRLIVASATLDADKFRDFFN 230
Cdd:cd17985 150 DLKVILMSATLNAELFSDYFN 170
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
7-229 |
1.82e-37 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 139.58 E-value: 1.82e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 7 PVKFWRPGT-----EGPGVSISEERQSLA-ENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETG 80
Cdd:cd17972 6 PQSNWNPWTssnidEGPLAFATPEQISMDlKNELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 81 CGKSTQIPQYLAE----AGWTAEGRVVgVTQPRRVAAVTV-RRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGM 155
Cdd:cd17972 86 CGKTTQVPQYILDdfiqNDRAAECNIV-VTQPRRISAVSVaERVAFERGEEVGKSCGYSVRFESVLPRPHASILFCTVGV 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119596413 156 LVREMmvdplltkyrltESFSLILSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFF 229
Cdd:cd17972 165 LLRKL------------EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYF 226
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
54-225 |
1.14e-36 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 135.54 E-value: 1.14e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVgVTQPRRVAAVTV-RRVAEERGAVLGHEVG 132
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKII-VLEPRRVAARAAaRRLATLLGEAPGETVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 133 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKyrltesfsliLSVIMLDEAHERTLYTDIAIGLLKKIQK-KRGDL 211
Cdd:cd17990 80 YRVRGESRVGR-RTRVEVVTEGVLLRRLQRDPELSG----------VGAVILDEFHERSLDADLALALLLEVQQlLRDDL 148
|
170
....*....|....
gi 119596413 212 RLIVASATLDADKF 225
Cdd:cd17990 149 RLLAMSATLDGDGL 162
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
54-229 |
1.22e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 126.83 E-value: 1.22e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAE----AGWTAEGRVVgVTQPRRVAAVTV-RRVAEERGAVLG 128
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdyvlRGRGARCNVV-ITQPRRISAVSVaQRVAHELGPNLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 129 HEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKyrltesfsliLSVIMLDEAHERTLYTDIAIGLLKKIQKKR 208
Cdd:cd17976 80 RNVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEG----------VSHVIVDEVHERDVNTDFLLILLKGVLQLN 149
|
170 180
....*....|....*....|.
gi 119596413 209 GDLRLIVASATLDADKFRDFF 229
Cdd:cd17976 150 PELRVVLMSATGDNQRLSRYF 170
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
54-218 |
4.34e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 125.32 E-value: 4.34e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGR--VVGVTQPRRVAAVTVR-RVAEERGAVLGHE 130
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQhgVVVCTQVHKQTAVWLAlRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 131 VGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKRGD 210
Cdd:cd17977 81 VGYVIPFENCCTN-ETILRYCTDDMLLREMMSDPLLESY----------GVIILDDAHERTVSTDVLLGLLKDVLLSRPE 149
|
....*...
gi 119596413 211 LRLIVASA 218
Cdd:cd17977 150 LKLVIITC 157
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
54-228 |
5.75e-33 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 125.01 E-value: 5.75e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIV-GETGCGKSTQIPQYLAEAGWT---AEGRVVgVTQPRRVAAVTVR-RVAEERGAVLG 128
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSGIVLVsGEPGSGKSTQVPQWCAEFALSrgfQKGQVT-VTQPHPLAARSLAlRVADEMDLNLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 129 HEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKIQKKR 208
Cdd:cd17986 80 HEVGYSIPQEDCTGP-NTILRFCWDRLLLQEMTSTPLLGAW----------GVVVLDEAQERSVASDSLLGLLKDVRLQR 148
|
170 180
....*....|....*....|
gi 119596413 209 GDLRLIVASATLDADKFRDF 228
Cdd:cd17986 149 PELRVVVVTSPALEPKLRAF 168
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
54-230 |
6.09e-32 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 122.25 E-value: 6.09e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGW-TAEGRVVGVTQPRRVAAVTV-RRVAEERGAVLGHEV 131
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYaNGIPCRIFCTQPRRLAAIAVaERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 132 GYCIRFDDCTDQlATRIKFLTDGMLVREMMVDplltkyrlTESFSLILSVImLDEAHERTLYTDIAIGLLKKIQKKRGDL 211
Cdd:cd17987 81 GYQIRLESRVSP-KTLLTFCTNGVLLRTLMAG--------DSALSTVTHVI-VDEVHERDRFSDFLLTKLRDILQKHPNL 150
|
170
....*....|....*....
gi 119596413 212 RLIVASATLDADKFRDFFN 230
Cdd:cd17987 151 KLILSSAALDVNLFIRYFG 169
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
54-229 |
8.82e-28 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 110.28 E-value: 8.82e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQY-LAEAGWTAEGRVVGVTQPRRVAAVTV-RRVAEERGAVLGHEV 131
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFiLDHYYKRGKYCNIVVTQPRRIAAISIaRRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 132 GYCIRFDDcTDQLATRIKFLTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKK-IQKKRGD 210
Cdd:cd17988 81 GYQVGLER-PASEETRLIYCTTGVLLQKLINNKTLTEY----------THIILDEVHERDQELDFLLLVVRRlLRTNSRH 149
|
170
....*....|....*....
gi 119596413 211 LRLIVASATLDADKFRDFF 229
Cdd:cd17988 150 VKIILMSATISCKEFADYF 168
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
468-557 |
1.06e-26 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 104.63 E-value: 1.06e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 468 ALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVP----PNQKSHAIRV 543
Cdd:pfam04408 1 ALELLYYLGALDEDGELT-PLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnfldPRSAAKAARR 79
|
90 100
....*....|....*....|....*
gi 119596413 544 HRKFAVEE-----------GDHLTM 557
Cdd:pfam04408 80 RRRAADEKarakfarldleGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
474-558 |
7.07e-25 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 98.49 E-value: 7.07e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 474 ALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFvvPPNQKSHAIRVHRKFAVEEGD 553
Cdd:smart00847 1 ELGALDDDGRLT-PLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESD 77
|
....*
gi 119596413 554 HLTML 558
Cdd:smart00847 78 HLTLL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
615-692 |
1.93e-21 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 88.85 E-value: 1.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 615 VLRCIVSGFFANAARF-HSTGAYRTIRDDHELHIHPASVLY--AEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAP 691
Cdd:pfam07717 1 LRAALAAGLYPNVARRdPKGKGYTTLSDNQRVFIHPSSVLFneKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
.
gi 119596413 692 H 692
Cdd:pfam07717 81 H 81
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
53-233 |
1.77e-17 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 81.38 E-value: 1.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 53 KLPVFKLRNH----ILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVRRVAEERGAVLG 128
Cdd:smart00487 3 KFGFEPLRPYqkeaIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 129 HEVGYCIRFDDCTDQLA------TRIKFLTDGMLVREMMVDPLLTKYrltesfsliLSVIMLDEAHERT--LYTDIAIGL 200
Cdd:smart00487 83 LKVVGLYGGDSKREQLRklesgkTDILVTTPGRLLDLLENDKLSLSN---------VDLVILDEAHRLLdgGFGDQLEKL 153
|
170 180 190
....*....|....*....|....*....|....*
gi 119596413 201 LKKIQKKRgdlRLIVASATL--DADKFRDFFNQNE 233
Cdd:smart00487 154 LKLLPKNV---QLLLLSATPpeEIENLLELFLNDP 185
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
310-405 |
8.82e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 66.85 E-value: 8.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 310 LARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFvklraynprtaieclvvv 389
Cdd:smart00490 3 LAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------ 64
|
90
....*....|....*.
gi 119596413 390 PVSQASANQRAGRGGR 405
Cdd:smart00490 65 PWSPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
271-405 |
1.79e-12 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 64.15 E-value: 1.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 271 VETVVKIHQTEGDGDVLAFLTGQEEVETvvSMLIEqaralartgmKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVA 350
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLEA--ELLLE----------KEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVA 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 119596413 351 TNVAETSITISGIVYVIDCGFVklraYNPRTAIeclvvvpvsqasanQRAGRGGR 405
Cdd:pfam00271 71 TDVAERGLDLPDVDLVINYDLP----WNPASYI--------------QRIGRAGR 107
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
41-416 |
6.49e-09 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 59.22 E-value: 6.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 41 PYAALSIEQQRQklpVFKLrnhilyLIENYQtVVIVGETGCGKSTQIPQ------YLAeAGWTAEGRVVGVTQPRRVAaV 114
Cdd:PHA02653 160 PLASLQPDVQLK---IFEA------WISRKP-VVLTGGTGVGKTSQVPKlllwfnYLF-GGFDNLDKIDPNFIERPIV-L 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 115 TVRRVAEER--GAVLGHEVGY--------CIRFDDCTDQLA-TRIKFltDGMLV---RemmvdplLTKYRLTESfslilS 180
Cdd:PHA02653 228 SLPRVALVRlhSITLLKSLGFdeidgspiSLKYGSIPDELInTNPKP--YGLVFsthK-------LTLNKLFDY-----G 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 181 VIMLDEAHERTLYTDIAIGLLKkiqKKRGDLR-LIVASATL--DADKFRDFFNqnetsDPArdtcvILTVEGRT-FPVDI 256
Cdd:PHA02653 294 TVIIDEVHEHDQIGDIIIAVAR---KHIDKIRsLFLMTATLedDRDRIKEFFP-----NPA-----FVHIPGGTlFPISE 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 257 FYL---QSPvPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETvVSMLIEQARALArtgmKRH--LRVLPMYAGLPSF 331
Cdd:PHA02653 361 VYVknkYNP-KNKRAYIEEEKKNIVTALKKYTPPKGSSGIVFVAS-VSQCEEYKKYLE----KRLpiYDFYIIHGKVPNI 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 332 EQM--KVF--ERVSrsvrkVIVATNVAETSITISGIVYVIDCGfvklRAYNPRtaieclvvvP-------VSQASANQRA 400
Cdd:PHA02653 435 DEIleKVYssKNPS-----IIISTPYLESSVTIRNATHVYDTG----RVYVPE---------PfggkemfISKSMRTQRK 496
|
410
....*....|....*.
gi 119596413 401 GRGGRSRSGKCYRLYT 416
Cdd:PHA02653 497 GRVGRVSPGTYVYFYD 512
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
73-219 |
2.29e-06 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 47.78 E-value: 2.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 73 VVIVGETGCGKSTQIPQYLAEAGWTAEGRVVgVTQPRRVAAV-TVRRVAEERG-----AVLGHEVGYCIRFDDCTDQLat 146
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGKKVL-VLVPTKALALqTAERLRELFGpgirvAVLVGGSSAEEREKNKLGDA-- 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119596413 147 RIKFLTDGMLVREMMVDPLLTKYRltesfsliLSVIMLDEAHeRTLYTD--IAIGLLKKIQKKRGDLRLIVASAT 219
Cdd:cd00046 81 DIIIATPDMLLNLLLREDRLFLKD--------LKLIIVDEAH-ALLIDSrgALILDLAVRKAGLKNAQVILLSAT 146
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
270-420 |
2.86e-04 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 44.09 E-value: 2.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 270 TVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIE----------QARALARTGMKRHlrvlpmyaglpsfEQMKVFER 339
Cdd:PRK13766 352 LREIVKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKegikavrfvgQASKDGDKGMSQK-------------EQIEILDK 418
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 340 VSRSVRKVIVATNVAETSITISGIVYVIdcgFvklraYNPrtaieclvvVPvSQASANQRAGRGGRSRSGKCYRLYTE-- 417
Cdd:PRK13766 419 FRAGEFNVLVSTSVAEEGLDIPSVDLVI---F-----YEP---------VP-SEIRSIQRKGRTGRQEEGRVVVLIAKgt 480
|
....*
gi 119596413 418 --EAF 420
Cdd:PRK13766 481 rdEAY 485
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
71-219 |
4.38e-04 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 41.38 E-value: 4.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 71 QTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVgVTQPRRVAAvtvrrvAEERGAVLGHEVGYCIRFDDCTDQLATRIKF 150
Cdd:cd17931 2 QLTVLDLHPGAGKTTRVLPQIIREAIKKRLRTL-VLAPTRVVA------AEMYEALRGLPIRYRTGAVKEEHGGNEIVDY 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119596413 151 LTDGMLVREMMVDPLLTKYrltesfslilSVIMLDEAHERTLYTDIAIGLLKKiQKKRGDLRLIVASAT 219
Cdd:cd17931 75 MCHGTFTCRLLSPKRVPNY----------NLIIMDEAHFTDPASIAARGYIHT-RVEMGEAAVIFMTAT 132
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
338-415 |
1.41e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 38.07 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119596413 338 ERVSRSVrKVIVATNVAETSITISGIVYVIDCGFVKlraynprtaieclvvvpvSQASANQRAGRGGR--SRSGKCYRLY 415
Cdd:cd18785 17 EEIASSL-EILVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRggKDEGEVILFV 77
|
|
| |
