|
Name |
Accession |
Description |
Interval |
E-value |
| MT super family |
cl37598 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
833-1177 |
6.33e-171 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
The actual alignment was detected with superfamily member pfam12777:
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 526.95 E-value: 6.33e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 833 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 912
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 913 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 992
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 993 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 1072
Cdd:pfam12777 161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1073 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 1152
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 119614142 1153 FVSYVGPFTRQYRQELVHCKWVPFL 1177
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
1955-2250 |
1.70e-120 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
:
Pssm-ID: 465677 Cd Length: 301 Bit Score: 382.74 E-value: 1.70e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1955 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 2032
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 2033 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 2112
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 2113 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 2191
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119614142 2192 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEKTAKWVLAGVALLL 2250
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
1202-1420 |
4.84e-109 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
:
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 346.74 E-value: 4.84e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1202 ATWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKYGM-DLKVTHLGQKGFLNAIETALAFGDVILIENLE 1280
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1281 ETIDPVLDPLLGRNTIKKG--KYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVS 1358
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119614142 1359 IERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEI 1420
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
561-820 |
8.59e-107 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
:
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 341.90 E-value: 8.59e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 561 MHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAK 640
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 641 NMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGMVDSRENCWKFFMARVRLQLKIILC 720
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 721 FSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSVSRRFIEETKGIEpVHKDSISLFMAHVHTTVNEMSTRYYQNER 800
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE-ELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 119614142 801 RHNYTTPKSFLEQISLFKNL 820
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| DYN1 super family |
cl34955 |
Dynein, heavy chain [Cytoskeleton]; |
2-1902 |
8.09e-93 |
|
Dynein, heavy chain [Cytoskeleton];
The actual alignment was detected with superfamily member COG5245:
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 338.12 E-value: 8.09e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 2 WIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY----------VNPQDLG-WNPYVASWI 70
Cdd:COG5245 1253 YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrlstkgVFLDELGdTKRYLDECL 1322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 71 DRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP-----ENVPSDSPKEVYEVYFV 143
Cdd:COG5245 1323 DFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKsielaAILEHKDLIVEMKRGIN 1400
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 144 FACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLLPwadkIAQFTMDPDVPLQV-- 217
Cdd:COG5245 1401 DVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNGS----IAGFELRGERVMLRke 1472
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 218 VLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNYYTTSTALQKILEKPLEK---- 293
Cdd:COG5245 1473 VVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCTMTPSKLSVLERETEYypnt 1551
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 294 KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNCQYVACMNP--MVGSFTINP 371
Cdd:COG5245 1552 GVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPgtDEGRVKYYE 1631
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 372 RLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTMMCNFlPTAIKFHYIFNLRDLS 450
Cdd:COG5245 1632 RFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELT 1706
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 451 NVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGID-SH---------MLLQQP 519
Cdd:COG5245 1707 RSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREMIaGHigeaeitfsMILFFG 1786
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 520 LIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQS 599
Cdd:COG5245 1787 MACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRGACD 1851
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 600 LSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDED 679
Cdd:COG5245 1852 AREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFSGNE 1931
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 680 VDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSV 758
Cdd:COG5245 1932 RIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKNRCFIDFKKLWDTEEMSQY 2011
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 759 SRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPKSFLEQISLFKNLLKKKQNEVS 829
Cdd:COG5245 2012 ANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKIKFIGGLKVYDARCVIYIEELD 2091
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 830 EKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREKTIADAEERKVTAIQTEVFQKQ 909
Cdd:COG5245 2092 CTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSVFVEAPRDMLFLLEEEVRKR 2170
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 910 RECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGRVPKDrsWKAAKVFMgKVDDFL 988
Cdd:COG5245 2171 KGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEAKI--WFGEQQSL-RRDDFI 2244
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 989 QALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAAT 1067
Cdd:COG5245 2245 RIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGEAFLVE 2324
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1068 EKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDV 1147
Cdd:COG5245 2325 DRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKLMVELDGDG 2404
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1148 LLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDDATIATWNNEGLPSDRMSTENA 1219
Cdd:COG5245 2405 HPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DFKEEACSTDYGLENSRIRKDLQ 2479
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1220 AILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVILIENlEETIDPVLDPLLGRNTI 1296
Cdd:COG5245 2480 DLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKIIGD-AEALDEEIGRLIKEEFK 2550
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1297 KKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVSIERPDLEKLKLVLTKH 1374
Cdd:COG5245 2551 SNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKALNAL 2630
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1375 QNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKINEARECYRPVAARASLLYFV 1454
Cdd:COG5245 2631 KACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESIRVE 2710
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1455 INDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLFEKDKLTFLSQMAFQILLRKKE 1534
Cdd:COG5245 2711 IAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHEDRSGFIHRLDVSFLLRTKR 2779
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1535 IdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkWVESECPEKEKLPQ-EWKKKSL 1613
Cdd:COG5245 2780 F----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-DNRTHSTILTSNSKtNPYKEYT 2846
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1614 IQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSPGVDALKDLEILGKRlgftids 1692
Cdd:COG5245 2847 YNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKKSLENERNVDRLGSK------- 2900
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1693 gkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRDYRVFMSAESAPTPDEHIIPQG 1772
Cdd:COG5245 2901 ----------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVCGKVKNMWTSMVDADMLPIQLL 2970
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1773 LLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTI 1851
Cdd:COG5245 2971 IAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEF 3044
|
1930 1940 1950 1960 1970
....*....|....*....|....*....|....*....|....*....|....*..
gi 119614142 1852 CASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFMN 1902
Cdd:COG5245 3045 KTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MT |
pfam12777 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
833-1177 |
6.33e-171 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 526.95 E-value: 6.33e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 833 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 912
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 913 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 992
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 993 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 1072
Cdd:pfam12777 161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1073 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 1152
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 119614142 1153 FVSYVGPFTRQYRQELVHCKWVPFL 1177
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
1955-2250 |
1.70e-120 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 382.74 E-value: 1.70e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1955 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 2032
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 2033 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 2112
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 2113 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 2191
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119614142 2192 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEKTAKWVLAGVALLL 2250
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
1202-1420 |
4.84e-109 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 346.74 E-value: 4.84e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1202 ATWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKYGM-DLKVTHLGQKGFLNAIETALAFGDVILIENLE 1280
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1281 ETIDPVLDPLLGRNTIKKG--KYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVS 1358
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119614142 1359 IERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEI 1420
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
561-820 |
8.59e-107 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 341.90 E-value: 8.59e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 561 MHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAK 640
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 641 NMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGMVDSRENCWKFFMARVRLQLKIILC 720
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 721 FSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSVSRRFIEETKGIEpVHKDSISLFMAHVHTTVNEMSTRYYQNER 800
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE-ELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 119614142 801 RHNYTTPKSFLEQISLFKNL 820
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
2-1902 |
8.09e-93 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 338.12 E-value: 8.09e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 2 WIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY----------VNPQDLG-WNPYVASWI 70
Cdd:COG5245 1253 YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrlstkgVFLDELGdTKRYLDECL 1322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 71 DRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP-----ENVPSDSPKEVYEVYFV 143
Cdd:COG5245 1323 DFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKsielaAILEHKDLIVEMKRGIN 1400
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 144 FACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLLPwadkIAQFTMDPDVPLQV-- 217
Cdd:COG5245 1401 DVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNGS----IAGFELRGERVMLRke 1472
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 218 VLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNYYTTSTALQKILEKPLEK---- 293
Cdd:COG5245 1473 VVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCTMTPSKLSVLERETEYypnt 1551
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 294 KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNCQYVACMNP--MVGSFTINP 371
Cdd:COG5245 1552 GVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPgtDEGRVKYYE 1631
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 372 RLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTMMCNFlPTAIKFHYIFNLRDLS 450
Cdd:COG5245 1632 RFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELT 1706
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 451 NVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGID-SH---------MLLQQP 519
Cdd:COG5245 1707 RSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREMIaGHigeaeitfsMILFFG 1786
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 520 LIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQS 599
Cdd:COG5245 1787 MACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRGACD 1851
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 600 LSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDED 679
Cdd:COG5245 1852 AREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFSGNE 1931
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 680 VDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSV 758
Cdd:COG5245 1932 RIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKNRCFIDFKKLWDTEEMSQY 2011
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 759 SRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPKSFLEQISLFKNLLKKKQNEVS 829
Cdd:COG5245 2012 ANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKIKFIGGLKVYDARCVIYIEELD 2091
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 830 EKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREKTIADAEERKVTAIQTEVFQKQ 909
Cdd:COG5245 2092 CTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSVFVEAPRDMLFLLEEEVRKR 2170
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 910 RECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGRVPKDrsWKAAKVFMgKVDDFL 988
Cdd:COG5245 2171 KGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEAKI--WFGEQQSL-RRDDFI 2244
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 989 QALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAAT 1067
Cdd:COG5245 2245 RIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGEAFLVE 2324
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1068 EKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDV 1147
Cdd:COG5245 2325 DRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKLMVELDGDG 2404
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1148 LLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDDATIATWNNEGLPSDRMSTENA 1219
Cdd:COG5245 2405 HPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DFKEEACSTDYGLENSRIRKDLQ 2479
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1220 AILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVILIENlEETIDPVLDPLLGRNTI 1296
Cdd:COG5245 2480 DLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKIIGD-AEALDEEIGRLIKEEFK 2550
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1297 KKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVSIERPDLEKLKLVLTKH 1374
Cdd:COG5245 2551 SNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKALNAL 2630
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1375 QNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKINEARECYRPVAARASLLYFV 1454
Cdd:COG5245 2631 KACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESIRVE 2710
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1455 INDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLFEKDKLTFLSQMAFQILLRKKE 1534
Cdd:COG5245 2711 IAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHEDRSGFIHRLDVSFLLRTKR 2779
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1535 IdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkWVESECPEKEKLPQ-EWKKKSL 1613
Cdd:COG5245 2780 F----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-DNRTHSTILTSNSKtNPYKEYT 2846
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1614 IQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSPGVDALKDLEILGKRlgftids 1692
Cdd:COG5245 2847 YNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKKSLENERNVDRLGSK------- 2900
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1693 gkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRDYRVFMSAESAPTPDEHIIPQG 1772
Cdd:COG5245 2901 ----------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVCGKVKNMWTSMVDADMLPIQLL 2970
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1773 LLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTI 1851
Cdd:COG5245 2971 IAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEF 3044
|
1930 1940 1950 1960 1970
....*....|....*....|....*....|....*....|....*....|....*..
gi 119614142 1852 CASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFMN 1902
Cdd:COG5245 3045 KTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
| AAA_7 |
pfam12775 |
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ... |
210-385 |
3.17e-89 |
|
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).
Pssm-ID: 463698 [Multi-domain] Cd Length: 179 Bit Score: 288.14 E-value: 3.17e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 210 DPDVPLQVVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASLS-EDYIVSRVPFNYYTTSTALQKILE 288
Cdd:pfam12775 2 PPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDkEKYLPLFINFSAQTTSNQTQDIIE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 289 KPLEKKAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNCQYVACMNPMVGS-F 367
Cdd:pfam12775 82 SKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGrN 161
|
170
....*....|....*...
gi 119614142 368 TINPRLQRHFTVFAFNFP 385
Cdd:pfam12775 162 DITPRLLRHFNVFNITFP 179
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1048-1143 |
4.58e-04 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.89 E-value: 4.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1048 DVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKI 1127
Cdd:COG4372 60 ELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIA 139
|
90
....*....|....*.
gi 119614142 1128 RWGQSIKSFEAQEKTL 1143
Cdd:COG4372 140 ELQSEIAEREEELKEL 155
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
840-934 |
3.83e-03 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 42.02 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 840 QKLKTTASQVGDLKARLASQEAEL-QLRNHDAEALITKIGLQTEKVSREKTIADAEER--KVTAIQTEVFQKQ-RECEAD 915
Cdd:TIGR04320 247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQKElaNAQAQALQTAQNNlATAQAA 326
|
90
....*....|....*....
gi 119614142 916 LLKAEPALVAATAALNTLN 934
Cdd:TIGR04320 327 LANAEARLAKAKEALANLN 345
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MT |
pfam12777 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
833-1177 |
6.33e-171 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 526.95 E-value: 6.33e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 833 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 912
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 913 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 992
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 993 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 1072
Cdd:pfam12777 161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1073 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 1152
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 119614142 1153 FVSYVGPFTRQYRQELVHCKWVPFL 1177
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
1955-2250 |
1.70e-120 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 382.74 E-value: 1.70e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1955 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 2032
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 2033 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 2112
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 2113 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 2191
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119614142 2192 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEKTAKWVLAGVALLL 2250
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
1202-1420 |
4.84e-109 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 346.74 E-value: 4.84e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1202 ATWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKYGM-DLKVTHLGQKGFLNAIETALAFGDVILIENLE 1280
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1281 ETIDPVLDPLLGRNTIKKG--KYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVS 1358
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119614142 1359 IERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEI 1420
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
561-820 |
8.59e-107 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 341.90 E-value: 8.59e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 561 MHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAK 640
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 641 NMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGMVDSRENCWKFFMARVRLQLKIILC 720
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 721 FSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSVSRRFIEETKGIEpVHKDSISLFMAHVHTTVNEMSTRYYQNER 800
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE-ELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 119614142 801 RHNYTTPKSFLEQISLFKNL 820
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
2-1902 |
8.09e-93 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 338.12 E-value: 8.09e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 2 WIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY----------VNPQDLG-WNPYVASWI 70
Cdd:COG5245 1253 YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrlstkgVFLDELGdTKRYLDECL 1322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 71 DRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP-----ENVPSDSPKEVYEVYFV 143
Cdd:COG5245 1323 DFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKsielaAILEHKDLIVEMKRGIN 1400
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 144 FACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLLPwadkIAQFTMDPDVPLQV-- 217
Cdd:COG5245 1401 DVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNGS----IAGFELRGERVMLRke 1472
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 218 VLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNYYTTSTALQKILEKPLEK---- 293
Cdd:COG5245 1473 VVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCTMTPSKLSVLERETEYypnt 1551
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 294 KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNCQYVACMNP--MVGSFTINP 371
Cdd:COG5245 1552 GVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPgtDEGRVKYYE 1631
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 372 RLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTMMCNFlPTAIKFHYIFNLRDLS 450
Cdd:COG5245 1632 RFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELT 1706
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 451 NVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGID-SH---------MLLQQP 519
Cdd:COG5245 1707 RSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREMIaGHigeaeitfsMILFFG 1786
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 520 LIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQS 599
Cdd:COG5245 1787 MACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRGACD 1851
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 600 LSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDED 679
Cdd:COG5245 1852 AREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFSGNE 1931
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 680 VDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSV 758
Cdd:COG5245 1932 RIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKNRCFIDFKKLWDTEEMSQY 2011
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 759 SRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPKSFLEQISLFKNLLKKKQNEVS 829
Cdd:COG5245 2012 ANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKIKFIGGLKVYDARCVIYIEELD 2091
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 830 EKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREKTIADAEERKVTAIQTEVFQKQ 909
Cdd:COG5245 2092 CTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSVFVEAPRDMLFLLEEEVRKR 2170
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 910 RECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGRVPKDrsWKAAKVFMgKVDDFL 988
Cdd:COG5245 2171 KGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEAKI--WFGEQQSL-RRDDFI 2244
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 989 QALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAAT 1067
Cdd:COG5245 2245 RIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGEAFLVE 2324
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1068 EKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDV 1147
Cdd:COG5245 2325 DRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKLMVELDGDG 2404
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1148 LLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDDATIATWNNEGLPSDRMSTENA 1219
Cdd:COG5245 2405 HPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DFKEEACSTDYGLENSRIRKDLQ 2479
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1220 AILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVILIENlEETIDPVLDPLLGRNTI 1296
Cdd:COG5245 2480 DLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKIIGD-AEALDEEIGRLIKEEFK 2550
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1297 KKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVSIERPDLEKLKLVLTKH 1374
Cdd:COG5245 2551 SNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKALNAL 2630
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1375 QNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKINEARECYRPVAARASLLYFV 1454
Cdd:COG5245 2631 KACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESIRVE 2710
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1455 INDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLFEKDKLTFLSQMAFQILLRKKE 1534
Cdd:COG5245 2711 IAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHEDRSGFIHRLDVSFLLRTKR 2779
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1535 IdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkWVESECPEKEKLPQ-EWKKKSL 1613
Cdd:COG5245 2780 F----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-DNRTHSTILTSNSKtNPYKEYT 2846
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1614 IQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSPGVDALKDLEILGKRlgftids 1692
Cdd:COG5245 2847 YNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKKSLENERNVDRLGSK------- 2900
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1693 gkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRDYRVFMSAESAPTPDEHIIPQG 1772
Cdd:COG5245 2901 ----------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVCGKVKNMWTSMVDADMLPIQLL 2970
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1773 LLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTI 1851
Cdd:COG5245 2971 IAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEF 3044
|
1930 1940 1950 1960 1970
....*....|....*....|....*....|....*....|....*....|....*..
gi 119614142 1852 CASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFMN 1902
Cdd:COG5245 3045 KTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
| AAA_7 |
pfam12775 |
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ... |
210-385 |
3.17e-89 |
|
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).
Pssm-ID: 463698 [Multi-domain] Cd Length: 179 Bit Score: 288.14 E-value: 3.17e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 210 DPDVPLQVVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASLS-EDYIVSRVPFNYYTTSTALQKILE 288
Cdd:pfam12775 2 PPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDkEKYLPLFINFSAQTTSNQTQDIIE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 289 KPLEKKAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNCQYVACMNPMVGS-F 367
Cdd:pfam12775 82 SKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGrN 161
|
170
....*....|....*...
gi 119614142 368 TINPRLQRHFTVFAFNFP 385
Cdd:pfam12775 162 DITPRLLRHFNVFNITFP 179
|
|
| AAA_lid_11 |
pfam18198 |
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ... |
1813-1949 |
5.79e-67 |
|
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.
Pssm-ID: 465676 Cd Length: 139 Bit Score: 222.72 E-value: 5.79e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1813 FKSILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYLEANS-KVPWEDLRYLFGEIMYGGHITDDWDRK 1891
Cdd:pfam18198 1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDEYDeKIPWDALRYLIGEINYGGRVTDDWDRR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 119614142 1892 LCRVYLEEFMNPSLIEDELMLAPG-FAAPPYLDYAGYHQYIEEMLPPESPALYGLHPNA 1949
Cdd:pfam18198 81 LLNTYLEEFFNPEVLEEDFKFSPSlYYIPPDGDLEDYLEYIESLPLVDSPEVFGLHPNA 139
|
|
| Dynein_heavy |
pfam03028 |
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ... |
1660-1781 |
1.27e-49 |
|
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.
Pssm-ID: 460782 Cd Length: 115 Bit Score: 171.86 E-value: 1.27e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1660 SPATPIFFILSPGVDALKDLEILGKRLGFTidsGKFHNVSLGQGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEK 1739
Cdd:pfam03028 1 SPTTPLIFILSPGSDPTADLEKLAKKLGFG---GKLHSISLGQGQGPIAEKLIEEAAKEGGWVLLQNCHLALSWMPELEK 77
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 119614142 1740 LLERF-SQGSHRDYRVFMSAEsaPTPDehiIPQGLLENSIKIT 1781
Cdd:pfam03028 78 ILEELpEETLHPDFRLWLTSE--PSPK---FPISILQNSIKIT 115
|
|
| AAA_lid_1 |
pfam17857 |
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3. |
418-515 |
4.26e-38 |
|
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
Pssm-ID: 465535 [Multi-domain] Cd Length: 100 Bit Score: 138.53 E-value: 4.26e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 418 LIQATIAFHQTMMCNFLPTAIKFHYIFNLRDLSNVFQGILFASPECLKGPLDLIHLWLHESARVYGDKLIDKKDCDLFQR 497
Cdd:pfam17857 1 LIAAALAFHQKIAATFLPTAIKFHYIFNLRDFANIFQGILFSSAECLKSPLDLIRLWLHESERVYGDKMVDEKDFDLFDK 80
|
90
....*....|....*...
gi 119614142 498 RMLETAYKYFEGIDSHML 515
Cdd:pfam17857 81 IQMASLKKFFDDIEDELE 98
|
|
| Dynein_AAA_lid |
pfam17852 |
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ... |
85-202 |
1.06e-30 |
|
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.
Pssm-ID: 465532 [Multi-domain] Cd Length: 126 Bit Score: 118.15 E-value: 1.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 85 LFDKYVPACLDKLRTSFKTITSIPESSLVQTLCVLLECLLTP-------ENVPSDSPKEVYEVYFVFACIWAFGGTLLQD 157
Cdd:pfam17852 4 LFEWLVPPALEFVRKNCKEIVPTSDLNLVQSLCRLLESLLDEvleyngvHPLSPDKLKEYLEKLFLFALVWSIGGTLDED 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 119614142 158 QisdyQADFSRWWQKEMKAVKFP--SQGTIFDYYVDHKTKKLLPWAD 202
Cdd:pfam17852 84 S----RKKFDEFLRELFSGLDLPppEKGTVYDYFVDLEKGEWVPWSD 126
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
241-377 |
1.88e-06 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 49.21 E-value: 1.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 241 PLMLVGNAGVGKTvFVGDTLASLSEDYIVSRVPFNYYTTSTALQKILEkPLEKKAGHNYGP---GGNKKLIYFIDDMNMP 317
Cdd:pfam07728 1 GVLLVGPPGTGKT-ELAERLAAALSNRPVFYVQLTRDTTEEDLFGRRN-IDPGGASWVDGPlvrAAREGEIAVLDEINRA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119614142 318 EVDLYGTVqpHTLI---RQHIDYGHWydrqkVMLKEIHNCQYVACMNP-MVGSFTINPRLQRHF 377
Cdd:pfam07728 79 NPDVLNSL--LSLLderRLLLPDGGE-----LVKAAPDGFRLIATMNPlDRGLNELSPALRSRF 135
|
|
| Laminin_II |
pfam06009 |
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ... |
1059-1123 |
4.17e-04 |
|
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 368703 [Multi-domain] Cd Length: 138 Bit Score: 42.47 E-value: 4.17e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119614142 1059 ANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELE 1123
Cdd:pfam06009 1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLE 65
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1048-1143 |
4.58e-04 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.89 E-value: 4.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1048 DVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKI 1127
Cdd:COG4372 60 ELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIA 139
|
90
....*....|....*.
gi 119614142 1128 RWGQSIKSFEAQEKTL 1143
Cdd:COG4372 140 ELQSEIAEREEELKEL 155
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1053-1143 |
8.11e-04 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.12 E-value: 8.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1053 RQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQS 1132
Cdd:COG4372 51 REELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQ 130
|
90
....*....|.
gi 119614142 1133 IKSFEAQEKTL 1143
Cdd:COG4372 131 RKQLEAQIAEL 141
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
1055-1125 |
1.21e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 43.67 E-value: 1.21e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119614142 1055 ALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAK 1125
Cdd:COG3883 10 TPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE 80
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1053-1143 |
1.68e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 43.35 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1053 RQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQS 1132
Cdd:COG4372 79 EEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQ 158
|
90
....*....|.
gi 119614142 1133 IKSFEAQEKTL 1143
Cdd:COG4372 159 LESLQEELAAL 169
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
840-934 |
3.83e-03 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 42.02 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 840 QKLKTTASQVGDLKARLASQEAEL-QLRNHDAEALITKIGLQTEKVSREKTIADAEER--KVTAIQTEVFQKQ-RECEAD 915
Cdd:TIGR04320 247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQKElaNAQAQALQTAQNNlATAQAA 326
|
90
....*....|....*....
gi 119614142 916 LLKAEPALVAATAALNTLN 934
Cdd:TIGR04320 327 LANAEARLAKAKEALANLN 345
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
1053-1143 |
6.97e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 41.85 E-value: 6.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614142 1053 RQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQS 1132
Cdd:COG1196 252 EAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEE 331
|
90
....*....|.
gi 119614142 1133 IKSFEAQEKTL 1143
Cdd:COG1196 332 LEELEEELEEL 342
|
|
| |
