NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|119631620|gb|EAX11215|]
View 

hypothetical protein FLJ13984, isoform CRA_b [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10614797)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.-.-|2.1.1.-
Gene Ontology:  GO:0032259|GO:0008757|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 150-236 4.97e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


:

Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 49.48  E-value: 4.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620  150 ILEVGCGAGNSVFPILNTLENSpesfLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDdglpYPFPDGILDVILLVFV 229
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGAR----VTGVDLSPEMLERARERAAEAGLNVEFVQGDAED----LPFPDGSFDLVVSSGV 72


                  ....*..
gi 119631620  230 LSSIHPD 236
Cdd:pfam13649  73 LHHLPDP 79
 
Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 150-236 4.97e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 49.48  E-value: 4.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620  150 ILEVGCGAGNSVFPILNTLENSpesfLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDdglpYPFPDGILDVILLVFV 229
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGAR----VTGVDLSPEMLERARERAAEAGLNVEFVQGDAED----LPFPDGSFDLVVSSGV 72


                  ....*..
gi 119631620  230 LSSIHPD 236
Cdd:pfam13649  73 LHHLPDP 79
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 149-239 6.90e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.30  E-value: 6.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620 149 RILEVGCGAGNSVFPILNTlenspESFLYCCDFASGAVELVKShssyRATQCFAFVHDVCDDGLPYPFPDGILDVILLVF 228
Cdd:COG2226   25 RVLDLGCGTGRLALALAER-----GARVTGVDISPEMLELARE----RAAEAGLNVEFVVGDAEDLPFPDGSFDLVISSF 95

                         90
                 ....*....|..
gi 119631620 229 VLSSI-HPDRTL 239
Cdd:COG2226   96 VLHHLpDPERAL 107
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 149-241 3.45e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 41.65  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620 149 RILEVGCGAGNsvfpILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHdvCDDGLPYPFPDGILDVILLVF 228
Cdd:cd02440    1 RVLDLGCGTGA----LALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLK--GDAEELPPEADESFDVIISDP 74

                         90
                 ....*....|...
gi 119631620 229 VLSSIHPDRTLFI 241
Cdd:cd02440   75 PLHHLVEDLARFL 87
PRK08317 PRK08317
hypothetical protein; Provisional
 140-239 5.04e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 43.00  E-value: 5.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620 140 LFPGSnatfRILEVGCGAGNSVFPILNtlENSPESFLYCCDFASGAVELVKShssyRATQCFAFVHDVCDDGLPYPFPDG 219
Cdd:PRK08317  17 VQPGD----RVLDVGCGPGNDARELAR--RVGPEGRVVGIDRSEAMLALAKE----RAAGLGPNVEFVRGDADGLPFPDG 86

                         90       100
                 ....*....|....*....|.
gi 119631620 220 ILDVILLVFVLSSIH-PDRTL 239
Cdd:PRK08317  87 SFDAVRSDRVLQHLEdPARAL 107
 
Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 150-236 4.97e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 49.48  E-value: 4.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620  150 ILEVGCGAGNSVFPILNTLENSpesfLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDdglpYPFPDGILDVILLVFV 229
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGAR----VTGVDLSPEMLERARERAAEAGLNVEFVQGDAED----LPFPDGSFDLVVSSGV 72


                  ....*..
gi 119631620  230 LSSIHPD 236
Cdd:pfam13649  73 LHHLPDP 79
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 149-239 6.90e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.30  E-value: 6.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620 149 RILEVGCGAGNSVFPILNTlenspESFLYCCDFASGAVELVKShssyRATQCFAFVHDVCDDGLPYPFPDGILDVILLVF 228
Cdd:COG2226   25 RVLDLGCGTGRLALALAER-----GARVTGVDISPEMLELARE----RAAEAGLNVEFVVGDAEDLPFPDGSFDLVISSF 95

                         90
                 ....*....|..
gi 119631620 229 VLSSI-HPDRTL 239
Cdd:COG2226   96 VLHHLpDPERAL 107
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 151-239 8.61e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 46.21  E-value: 8.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620  151 LEVGCGAGNSVFPILNTLensPESFLYCCDFASGAVELVKSH-SSYRATQCFAFVHDVCDDGLPYPFPdgiLDVILLVFV 229
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL---PGLEYTGLDISPAALEAARERlAALGLLNAVRVELFQLDLGELDPGS---FDVVVASNV 74

                          90
                  ....*....|.
gi 119631620  230 LSSI-HPDRTL 239
Cdd:pfam08242  75 LHHLaDPRAVL 85
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 149-241 3.45e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 41.65  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620 149 RILEVGCGAGNsvfpILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHdvCDDGLPYPFPDGILDVILLVF 228
Cdd:cd02440    1 RVLDLGCGTGA----LALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLK--GDAEELPPEADESFDVIISDP 74

                         90
                 ....*....|...
gi 119631620 229 VLSSIHPDRTLFI 241
Cdd:cd02440   75 PLHHLVEDLARFL 87
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 151-239 3.63e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 41.50  E-value: 3.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620  151 LEVGCGAGNSVFPILNTLENspesfLYCCDFASGAVELVKSHSSYRAtqcfafVHDVCDDGLPYPFPDGILDVILLVFVL 230
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR-----VTGVDISPEMLELAREKAPREG------LTFVVGDAEDLPFPDNSFDLVLSSEVL 69

                          90
                  ....*....|
gi 119631620  231 SSIH-PDRTL 239
Cdd:pfam08241  70 HHVEdPERAL 79
PRK08317 PRK08317
hypothetical protein; Provisional
 140-239 5.04e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 43.00  E-value: 5.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620 140 LFPGSnatfRILEVGCGAGNSVFPILNtlENSPESFLYCCDFASGAVELVKShssyRATQCFAFVHDVCDDGLPYPFPDG 219
Cdd:PRK08317  17 VQPGD----RVLDVGCGPGNDARELAR--RVGPEGRVVGIDRSEAMLALAKE----RAAGLGPNVEFVRGDADGLPFPDG 86

                         90       100
                 ....*....|....*....|.
gi 119631620 220 ILDVILLVFVLSSIH-PDRTL 239
Cdd:PRK08317  87 SFDAVRSDRVLQHLEdPARAL 107
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 140-237 1.89e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 41.06  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119631620 140 LFPGSNATFRILEVGCGAGNSVFPILNTLenspESFLYCCDFASGAVEL-VKSHSSYRATQCFAFVHDVCDdglPYPFPD 218
Cdd:COG0500   20 LLERLPKGGRVLDLGCGTGRNLLALAARF----GGRVIGIDLSPEAIALaRARAAKAGLGNVEFLVADLAE---LDPLPA 92

                         90
                 ....*....|....*....
gi 119631620 219 GILDVILLVFVLSSIHPDR 237
Cdd:COG0500   93 ESFDLVVAFGVLHHLPPEE 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH