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Conserved domains on  [gi|142131821|gb|ECV82286|]
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hypothetical protein GOS_2829250 [marine metagenome]

Protein Classification

DEAD/DEAH box helicase family protein( domain architecture ID 13029023)

DEAD/DEAH box helicase family protein such as a DEAD/DEAH box-containing ATP-dependent helicase, which catalyzes the unwinding of DNA or RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 16-178 1.19e-60

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 188.69  E-value: 1.19e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTEGQGvledhqKIWMIEPRRLATKAAAARLAESLGEDIG 95
Cdd:cd17990    2 PIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGG------KIIVLEPRRVAARAAARRLATLLGEAPG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  96 ARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPLLNPDLAVILMSA 175
Cdd:cd17990   76 ETVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRDDLRLLAMSA 155


                 ...
gi 142131821 176 TLD 178
Cdd:cd17990  156 TLD 158
 
Name Accession Description Interval E-value
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 16-178 1.19e-60

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 188.69  E-value: 1.19e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTEGQGvledhqKIWMIEPRRLATKAAAARLAESLGEDIG 95
Cdd:cd17990    2 PIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGG------KIIVLEPRRVAARAAARRLATLLGEAPG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  96 ARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPLLNPDLAVILMSA 175
Cdd:cd17990   76 ETVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRDDLRLLAMSA 155


                 ...
gi 142131821 176 TLD 178
Cdd:cd17990  156 TLD 158
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
10-187 2.67e-60

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 203.39  E-value: 2.67e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  10 TALSQFPIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALigaLTEGQGVledHQKIWMIEPrrlatkaaaarlaES 89
Cdd:COG1643    5 TYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLAL---LELGWGA---GGRIGMLEPrrlaaraaaermaEE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  90 LGEDIGARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPLLNPDLA 169
Cdd:COG1643   79 LGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALRPDLK 158

                        170       180
                 ....*....|....*....|.
gi 142131821 170 VILMSATLD---LSDLRNGCP 187
Cdd:COG1643  159 LLVMSATLDaerFARLLGDAP 179
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
 15-187 3.86e-47

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 166.87  E-value: 3.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   15 FPIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTEGQgvledhqKIWMIEPRRLATKAAAARLAESLGEDI 94
Cdd:TIGR01970   1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGG-------KIIMLEPRRLAARSAAQRLASQLGEAV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   95 GARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPLLNPDLAVILMS 174
Cdd:TIGR01970  74 GQTVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSLREDLKILAMS 153

                         170
                  ....*....|....*.
gi 142131821  175 ATLD---LSDLRNGCP 187
Cdd:TIGR01970 154 ATLDgerLSSLLPDAP 169
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 12-178 7.14e-44

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 157.78  E-value: 7.14e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  12 LSQFPIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALigaLTEGQGvledHQKIWMIEPRRLATKAAAARLAESLG 91
Cdd:PRK11664   1 MSSLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQL---LQHGGI----NGKIIMLEPRRLAARNVAQRLAEQLG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  92 EDIGARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPLLNPDLAVI 171
Cdd:PRK11664  74 EKPGETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGLRDDLKLL 153


                 ....*..
gi 142131821 172 LMSATLD 178
Cdd:PRK11664 154 IMSATLD 160
DEXDc smart00487
DEAD-like helicases superfamily;
34-177 4.56e-12

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 63.28  E-value: 4.56e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821    34 VLLQAPPGAGKTTRVPLALIGALTEGQG--VL---------EDHQKIWmieprrlatkaaaarlaESLGEDIGARIGYAV 102
Cdd:smart00487  27 VILAAPTGSGKTLAALLPALEALKRGKGgrVLvlvptrelaEQWAEEL-----------------KKLGPSLGLKVVGLY 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   103 RGEQKR-------SNRTQVEVITDGLFLRRLQSDP-SLDGVGCVIFDEFHERGRDADLSlaLLREARPLLNPDLAVILMS 174
Cdd:smart00487  90 GGDSKReqlrkleSGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLDGGFGD--QLEKLLKLLPKNVQLLLLS 167


                   ...
gi 142131821   175 ATL 177
Cdd:smart00487 168 ATP 170
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 22-178 1.69e-09

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 55.33  E-value: 1.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   22 EQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTEGQG-----VL-------EDHQKIWmieprrlatkaaaarlaES 89
Cdd:pfam00270   5 AEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNgpqalVLaptrelaEQIYEEL-----------------KK 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   90 LGEDIGARIGYAVRGEQKRSNRTQVE-----VITDGLFLRRLQSDPSLDGVGCVIFDEFHE---RGRDADLSLALLRear 161
Cdd:pfam00270  68 LGKGLGLKVASLLGGDSRKEQLEKLKgpdilVGTPGRLLDLLQERKLLKNLKLLVLDEAHRlldMGFGPDLEEILRR--- 144

                         170
                  ....*....|....*..
gi 142131821  162 plLNPDLAVILMSATLD 178
Cdd:pfam00270 145 --LPKKRQILLLSATLP 159
 
Name Accession Description Interval E-value
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 16-178 1.19e-60

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 188.69  E-value: 1.19e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTEGQGvledhqKIWMIEPRRLATKAAAARLAESLGEDIG 95
Cdd:cd17990    2 PIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGG------KIIVLEPRRVAARAAARRLATLLGEAPG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  96 ARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPLLNPDLAVILMSA 175
Cdd:cd17990   76 ETVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRDDLRLLAMSA 155


                 ...
gi 142131821 176 TLD 178
Cdd:cd17990  156 TLD 158
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
10-187 2.67e-60

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 203.39  E-value: 2.67e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  10 TALSQFPIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALigaLTEGQGVledHQKIWMIEPrrlatkaaaarlaES 89
Cdd:COG1643    5 TYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLAL---LELGWGA---GGRIGMLEPrrlaaraaaermaEE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  90 LGEDIGARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPLLNPDLA 169
Cdd:COG1643   79 LGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALRPDLK 158

                        170       180
                 ....*....|....*....|.
gi 142131821 170 VILMSATLD---LSDLRNGCP 187
Cdd:COG1643  159 LLVMSATLDaerFARLLGDAP 179
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
 15-187 3.86e-47

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 166.87  E-value: 3.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   15 FPIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTEGQgvledhqKIWMIEPRRLATKAAAARLAESLGEDI 94
Cdd:TIGR01970   1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGG-------KIIMLEPRRLAARSAAQRLASQLGEAV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   95 GARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPLLNPDLAVILMS 174
Cdd:TIGR01970  74 GQTVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSLREDLKILAMS 153

                         170
                  ....*....|....*.
gi 142131821  175 ATLD---LSDLRNGCP 187
Cdd:TIGR01970 154 ATLDgerLSSLLPDAP 169
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 12-178 7.14e-44

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 157.78  E-value: 7.14e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  12 LSQFPIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALigaLTEGQGvledHQKIWMIEPRRLATKAAAARLAESLG 91
Cdd:PRK11664   1 MSSLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQL---LQHGGI----NGKIIMLEPRRLAARNVAQRLAEQLG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  92 EDIGARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPLLNPDLAVI 171
Cdd:PRK11664  74 EKPGETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGLRDDLKLL 153


                 ....*..
gi 142131821 172 LMSATLD 178
Cdd:PRK11664 154 IMSATLD 160
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 32-187 2.03e-37

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 128.73  E-value: 2.03e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  32 ETVLLQAPPGAGKTTRVPLALIGALTEGQGvledHQKIWMIEPRRLATKAAAARLAESLGEDIGARIGYAVRGEQKRSNR 111
Cdd:cd17917    2 QVVVIVGETGSGKTTQVPQFLLEDGLAKGG----KGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSK 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 142131821 112 TQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPlLNPDLAVILMSATLDLSDLR---NGCP 187
Cdd:cd17917   78 TRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLR-KRPDLKVILMSATLDAEKFSsyfGGAP 155
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 16-187 3.20e-27

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 103.33  E-value: 3.20e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVP-LALIGALTEGQGVledHQKIWMIEPRRLATKAAAARLAESLGEDI 94
Cdd:cd17976    2 PVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPqFILEDYVLRGRGA---RCNVVITQPRRISAVSVAQRVAHELGPNL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  95 GARIGYAVRGEQKRSNRTQVEVI-TDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPlLNPDLAVILM 173
Cdd:cd17976   79 RRNVGYQVRLESRPPPRGGALLFcTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQ-LNPELRVVLM 157

                        170
                 ....*....|....*..
gi 142131821 174 SATLD---LSDLRNGCP 187
Cdd:cd17976  158 SATGDnqrLSRYFGGCP 174
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 16-178 1.95e-24

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 95.88  E-value: 1.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTEGQGVledhqkIWMIEPRRLATKAAAARLAESLGEDIG 95
Cdd:cd17978    2 PIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGGM------IGITQPRRVAAVSVAKRVAEEMGVELG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  96 ARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREA---RPLLN-PDLAVI 171
Cdd:cd17978   76 QLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAqrrRKEQKlSPLKVI 155


                 ....*..
gi 142131821 172 LMSATLD 178
Cdd:cd17978  156 IMSATLD 162
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 22-187 3.24e-24

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 95.29  E-value: 3.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  22 EQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTegQGVLEDHQKIWMIEPRRLATKAAAARLAESLGEDIGARIGYA 101
Cdd:cd17985    8 ETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSL--QGPPLPVANIICTQPRRISAISVAERVAQERAERVGQSVGYQ 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821 102 VRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARpLLNPDLAVILMSATLD--- 178
Cdd:cd17985   86 IRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLM-VQRPDLKVILMSATLNael 164


                 ....*....
gi 142131821 179 LSDLRNGCP 187
Cdd:cd17985  165 FSDYFNSCP 173
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 16-179 3.61e-23

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 92.52  E-value: 3.61e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALigaLTEGQGVledHQKIWMIEPRRLATKAAAARLAESLGEDIG 95
Cdd:cd17989    2 PVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKIC---LELGRGI---RGLIGHTQPRRLAARSVAERIAEELKTELG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  96 ARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPlLNPDLAVILMSA 175
Cdd:cd17989   76 GAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLP-RRPDLKVIITSA 154


                 ....
gi 142131821 176 TLDL 179
Cdd:cd17989  155 TIDA 158
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 31-178 2.15e-22

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 90.55  E-value: 2.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  31 GETvllqappGAGKTTRVPlaligaltegQGVLED---HQKIWMI---EPRRLATKAAAARLAESLGEDIGARIGYAVRG 104
Cdd:cd17973   36 GET-------GSGKTTQIP----------QFVLDDelpHQPKKLVactQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRF 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 142131821 105 EQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLRE-ARPllNPDLAVILMSATLD 178
Cdd:cd17973   99 EDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEvVRR--RPDLKLIVMSATLD 171
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 16-180 2.42e-22

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 90.19  E-value: 2.42e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGAltegqgvleDHQKIWMIEPRRLATKAAAARLAESLGEDIG 95
Cdd:cd17979    2 PIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAA---------GFRHIACTQPRRIACISLAKRVAFESLNQYG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  96 ARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPlLNPDLAVILMSA 175
Cdd:cd17979   73 SKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLR-LRPDLKLILMSA 151


                 ....*
gi 142131821 176 TLDLS 180
Cdd:cd17979  152 TINIE 156
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 16-178 6.46e-22

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 89.10  E-value: 6.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGAltegqGVLEDHQKIWMIEPRRLATKAAAARLAESLGEDIG 95
Cdd:cd17974    2 PVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEA-----GYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  96 ARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLRE-ARplLNPDLAVILMS 174
Cdd:cd17974   77 NEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDiAR--FRPDLKLLISS 154


                 ....
gi 142131821 175 ATLD 178
Cdd:cd17974  155 ATMD 158
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 16-187 1.07e-19

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 83.34  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPlaligaltegQGVLEDHQK------IWMIEPRRLATKAAAARLAES 89
Cdd:cd17987    2 PVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIP----------QFLLDDCYAngipcrIFCTQPRRLAAIAVAERVAAE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  90 LGEDIGARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQS-DPSLDGVGCVIFDEFHERGRDADLSLALLREARPlLNPDL 168
Cdd:cd17987   72 RGEKIGQTVGYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQ-KHPNL 150

                        170       180
                 ....*....|....*....|..
gi 142131821 169 AVILMSATLDLS---DLRNGCP 187
Cdd:cd17987  151 KLILSSAALDVNlfiRYFGSCP 172
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 16-187 1.07e-19

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 83.28  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRvplaligaLTegQGVLED-HQKIWMI---EPRRLATKAAAARLAESLG 91
Cdd:cd17983    2 PIFAVRQELLNVIRDNNVVIVVGETGSGKTTQ--------LT--QYLHEDgYTDYGMIgctQPRRVAAMSVAKRVSEEMG 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  92 EDIGARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLRE--ARpllNPDLA 169
Cdd:cd17983   72 VELGEEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREvvAR---RRDLK 148

                        170       180
                 ....*....|....*....|.
gi 142131821 170 VILMSATLD---LSDLRNGCP 187
Cdd:cd17983  149 LIVTSATMDadkFADFFGNVP 169
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 16-178 1.54e-19

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 82.92  E-value: 1.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVP--LALIGALTEGqgvledhqKIWMIEPRRLATKAAAARLAESLGED 93
Cdd:cd17971    7 PIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITqyLAEAGYTSRG--------KIGCTQPRRVAAMSVAKRVAEEFGCC 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  94 IGARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREArPLLNPDLAVILM 173
Cdd:cd17971   79 LGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKT-VQKRPDLKLIVT 157


                 ....*
gi 142131821 174 SATLD 178
Cdd:cd17971  158 SATLD 162
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 15-187 9.26e-19

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 80.67  E-value: 9.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  15 FPIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGAltegqgVLEDHQKIWMIEPRRLATKAAAARLAESLGEDI 94
Cdd:cd17984    1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEA------GFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  95 GARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLR----EARPLLNPDLAV 170
Cdd:cd17984   75 GSKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKklfqEKSPNRKEHLKV 154

                        170       180
                 ....*....|....*....|
gi 142131821 171 ILMSATLD---LSDLRNGCP 187
Cdd:cd17984  155 VVMSATLElakLSAFFGNCP 174
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 22-187 6.71e-18

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 78.73  E-value: 6.71e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  22 EQICSAVRPGETVLLQAPPGAGKTTRVP-LALIGALTEGQGvleDHQKIWMIEPRRLATKAAAARLAESLGED--IGARI 98
Cdd:cd17981    8 QEIINMIDNNQVTVISGETGCGKTTQVTqFILDDAIERGKG---SSCRIVCTQPRRISAISVAERVAAERAEScgLGNST 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  99 GYAVRGE-QKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPlLNPDLAVILMSATL 177
Cdd:cd17981   85 GYQIRLEsRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLP-FRSDLKVILMSATL 163

                        170
                 ....*....|...
gi 142131821 178 ---DLSDLRNGCP 187
Cdd:cd17981  164 naeKFSDYFNNCP 176
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 14-178 7.19e-18

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 82.80  E-value: 7.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   14 QFPIDALLEQICSAVRPGETVLLQAPPGAGKTTRVP---LALigalteGQGVledHQKIWMIEPRRLATKAAAARLAESL 90
Cdd:PRK11131   72 NLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPkicLEL------GRGV---KGLIGHTQPRRLAARTVANRIAEEL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   91 GEDIGARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPlLNPDLAV 170
Cdd:PRK11131  143 ETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLP-RRPDLKV 221


                  ....*...
gi 142131821  171 ILMSATLD 178
Cdd:PRK11131  222 IITSATID 229
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 16-184 1.03e-17

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 78.28  E-value: 1.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGAltegqGVLEDHQKIWMIEPRRLATKAAAARLAESLGEDIG 95
Cdd:cd17980    2 PVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEA-----GWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  96 ARIGYAVRGEQKRSN-RTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPlLNPDLAVILMS 174
Cdd:cd17980   77 HEVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQK-KRGDLRLIVAS 155

                        170
                 ....*....|
gi 142131821 175 ATLDLSDLRN 184
Cdd:cd17980  156 ATLDAEKFRD 165
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 13-187 2.85e-17

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 77.95  E-value: 2.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  13 SQFPIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPlaligaltegQGVLEDHQK--------IWMIEPRRLATKAAAA 84
Cdd:cd17972   57 ELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVP----------QYILDDFIQndraaecnIVVTQPRRISAVSVAE 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  85 RLAESLGEDIGARIGYAVRGEQKRSN-RTQVEVITDGLFLRRLQSdpSLDGVGCVIFDEFHERGRDADLSLALLREARPL 163
Cdd:cd17972  127 RVAFERGEEVGKSCGYSVRFESVLPRpHASILFCTVGVLLRKLEA--GIRGISHVIVDEIHERDINTDFLLVVLRDVVQA 204

                        170       180
                 ....*....|....*....|....*..
gi 142131821 164 LnPDLAVILMSATLDLSDLRN---GCP 187
Cdd:cd17972  205 Y-PDLRVILMSATIDTSMFCEyffNCP 230
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 16-185 1.75e-16

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 75.08  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGAlTEGQGVLEDHQKIWMIEPRRLATKAAAARLAESLGeDIG 95
Cdd:cd17982    2 PILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEA-GFGSPESDNPGMIGITQPRRVAAVSMAKRVAEELN-VFG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  96 ARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPL----------LN 165
Cdd:cd17982   80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLraklylqdqtVK 159

                        170       180
                 ....*....|....*....|
gi 142131821 166 PdLAVILMSATLDLSDLRNG 185
Cdd:cd17982  160 P-LKLVIMSATLRVEDFTEN 178
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 15-187 3.78e-16

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 73.80  E-value: 3.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  15 FPIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTEGQGVLEDHQkIWMIEPRRLATKAAAARLAESLGEDI 94
Cdd:cd17975    1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQKCN-IVCTQPRRISAMSLATRVCEELGCES 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  95 G-----ARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREarpLLN--PD 167
Cdd:cd17975   80 GpggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKE---ILHkrSD 156

                        170       180
                 ....*....|....*....|...
gi 142131821 168 LAVILMSATLD---LSDLRNGCP 187
Cdd:cd17975  157 LHLILMSATVDcekFSSYFTHCP 179
DEXDc smart00487
DEAD-like helicases superfamily;
34-177 4.56e-12

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 63.28  E-value: 4.56e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821    34 VLLQAPPGAGKTTRVPLALIGALTEGQG--VL---------EDHQKIWmieprrlatkaaaarlaESLGEDIGARIGYAV 102
Cdd:smart00487  27 VILAAPTGSGKTLAALLPALEALKRGKGgrVLvlvptrelaEQWAEEL-----------------KKLGPSLGLKVVGLY 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   103 RGEQKR-------SNRTQVEVITDGLFLRRLQSDP-SLDGVGCVIFDEFHERGRDADLSlaLLREARPLLNPDLAVILMS 174
Cdd:smart00487  90 GGDSKReqlrkleSGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLDGGFGD--QLEKLLKLLPKNVQLLLLS 167


                   ...
gi 142131821   175 ATL 177
Cdd:smart00487 168 ATP 170
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 16-182 4.65e-12

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 62.90  E-value: 4.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  16 PIDALLEQICSAVRPGETVLLQAPPGAGKTTRVPlaligaltegQGVLEDHQK------IWMIEPRRLATKAAAARLAES 89
Cdd:cd17988    2 PIYAKREEILSLIEANSVVIIKGATGCGKTTQLP----------QFILDHYYKrgkycnIVVTQPRRIAAISIARRVSQE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  90 LGEDIGARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARPLLNPDLA 169
Cdd:cd17988   72 REWTLGSLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRHVK 151

                        170
                 ....*....|...
gi 142131821 170 VILMSATLDLSDL 182
Cdd:cd17988  152 IILMSATISCKEF 164
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 20-175 1.50e-09

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 55.67  E-value: 1.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  20 LLEQICSavrPGETVLLQAPPGAGKTTRVP-----LALIGALTEGQgvledhqkIWMIEPRRLATKAAAARLAESLGEDI 94
Cdd:cd17986   10 FLEQLES---PSGIVLVSGEPGSGKSTQVPqwcaeFALSRGFQKGQ--------VTVTQPHPLAARSLALRVADEMDLNL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  95 GARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARpLLNPDLAVILMS 174
Cdd:cd17986   79 GHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVR-LQRPELRVVVVT 157


                 .
gi 142131821 175 A 175
Cdd:cd17986  158 S 158
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 22-178 1.69e-09

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 55.33  E-value: 1.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   22 EQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTEGQG-----VL-------EDHQKIWmieprrlatkaaaarlaES 89
Cdd:pfam00270   5 AEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNgpqalVLaptrelaEQIYEEL-----------------KK 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821   90 LGEDIGARIGYAVRGEQKRSNRTQVE-----VITDGLFLRRLQSDPSLDGVGCVIFDEFHE---RGRDADLSLALLRear 161
Cdd:pfam00270  68 LGKGLGLKVASLLGGDSRKEQLEKLKgpdilVGTPGRLLDLLQERKLLKNLKLLVLDEAHRlldMGFGPDLEEILRR--- 144

                         170
                  ....*....|....*..
gi 142131821  162 plLNPDLAVILMSATLD 178
Cdd:pfam00270 145 --LPKKRQILLLSATLP 159
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 31-176 2.02e-09

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 54.72  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  31 GETVLLQAPPGAGKTTRVPLALIGALTEGQGvledhqKIWMIEPRRLATKAAAarlaESLGE--DIGARIGYAVRG---E 105
Cdd:cd00046    1 GENVLITAPTGSGKTLAALLAALLLLLKKGK------KVLVLVPTKALALQTA----ERLRElfGPGIRVAVLVGGssaE 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 142131821 106 QKRSNRTQVEVI---TDGLFLRRLQSD--PSLDGVGCVIFDEFHERGRDADLSLALLREARPLLNPDLAVILMSAT 176
Cdd:cd00046   71 EREKNKLGDADIiiaTPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKNAQVILLSAT 146
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 93-175 4.82e-09

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 54.06  E-value: 4.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  93 DIGARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHERGRDADLSLALLREARpLLNPDLAVIL 172
Cdd:cd17977   76 NIGHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVL-LSRPELKLVI 154


                 ...
gi 142131821 173 MSA 175
Cdd:cd17977  155 ITC 157
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
11-177 1.88e-06

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 48.35  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  11 ALSQFPIDALL----EQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTEGQGVL-------------EDHQKIWmie 73
Cdd:COG1204   14 FLKERGIEELYppqaEALEAGLLEGKNLVVSAPTASGKTLIAELAILKALLNGGKALyivplralasekyREFKRDF--- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  74 prrlatkaaaarlaESLGEDIGARIG-YAVRGEqkRSNRTQVEVIT----DGLflrrLQSDPS-LDGVGCVIFDEFH--- 144
Cdd:COG1204   91 --------------EELGIKVGVSTGdYDSDDE--WLGRYDILVATpeklDSL----LRNGPSwLRDVDLVVVDEAHlid 150

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 142131821 145 --ERGRDADLSLALLREarplLNPDLAVILMSATL 177
Cdd:COG1204  151 deSRGPTLEVLLARLRR----LNPEAQIVALSATI 181
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 21-178 2.27e-06

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 46.49  E-value: 2.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  21 LEQICSAVRPGETVLLQAPPGAGKTTRVPLALIGALTEGQG--------------VLEDHQKiwmieprrlatkaaaarL 86
Cdd:cd17921    7 REALRALYLSGDSVLVSAPTSSGKTLIAELAILRALATSGGkavyiaptralvnqKEADLRE-----------------R 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  87 AESLGEDIGARIG-YAVRGEQKRsnRTQVEVIT----DGLfLRRLqSDPSLDGVGCVIFDEFH-----ERGRDADLSLAL 156
Cdd:cd17921   70 FGPLGKNVGLLTGdPSVNKLLLA--EADILVATpeklDLL-LRNG-GERLIQDVRLVVVDEAHligdgERGVVLELLLSR 145

                        170       180
                 ....*....|....*....|..
gi 142131821 157 LRearpLLNPDLAVILMSATLD 178
Cdd:cd17921  146 LL----RINKNARFVGLSATLP 163
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
17-181 5.37e-05

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 43.86  E-value: 5.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  17 IDALLEQICSAVRPGetvLLQAPPGAGKTtRVPLALIGALTEGQGVL-----ED--HQkiWMieprrlatkaaaarlaes 89
Cdd:COG1061   89 LEALLAALERGGGRG---LVVAPTGTGKT-VLALALAAELLRGKRVLvlvprREllEQ--WA------------------ 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  90 lgEDIGARIGYAVRGEQKRSNRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHErgrdadLSLALLREARPLLNPDLa 169
Cdd:COG1061  145 --EELRRFLGDPLAGGGKKDSDAPITVATYQSLARRAHLDELGDRFGLVIIDEAHH------AGAPSYRRILEAFPAAY- 215

                        170
                 ....*....|..
gi 142131821 170 VILMSATLDLSD 181
Cdd:COG1061  216 RLGLTATPFRSD 227
DEXHc_POLQ-like cd18026
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ...
 88-177 2.38e-04

DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.


Pssm-ID: 350784 [Multi-domain]  Cd Length: 202  Bit Score: 41.05  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  88 ESLGEDIGARI-GYAV---RGEQKRSNRTQVEVIT----DGLFlRRLQSDPSLDGVGCVIFDEFH---ERGRDADLSLAL 156
Cdd:cd18026   83 SPLFEELGFRVeGYAGnkgRSPPKRRKSLSVAVCTiekaNSLV-NSLIEEGRLDELGLVVVDELHmlgDGHRGALLELLL 161

                         90       100
                 ....*....|....*....|...
gi 142131821 157 --LREARPllnPDLAVILMSATL 177
Cdd:cd18026  162 tkLLYAAQ---KNIQIVGMSATL 181
DEXHc_LHR-like cd17922
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ...
 31-183 2.43e-04

DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350680 [Multi-domain]  Cd Length: 166  Bit Score: 40.64  E-value: 2.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  31 GETVLLQAPPGAGKTTRvplALIGALTEgqgVLEDHQK----IWmIEPrRLATKAAAARLAESLGEDIGARIGYAVR-GE 105
Cdd:cd17922    1 GRNVLIAAPTGSGKTEA---AFLPALSS---LADEPEKgvqvLY-ISP-LKALINDQERRLEEPLDEIDLEIPVAVRhGD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821 106 QKRSNRTQ-------VEVITD---GLFLRRLQSDPSLDGVGCVIFDEFHE-----RGRDADLSLALLREarpLLNPDLAV 170
Cdd:cd17922   73 TSQSEKAKqlknppgILITTPeslELLLVNKKLRELFAGLRYVVVDEIHAllgskRGVQLELLLERLRK---LTGRPLRR 149

                        170
                 ....*....|....
gi 142131821 171 ILMSATL-DLSDLR 183
Cdd:cd17922  150 IGLSATLgNLEEAA 163
DEXHc_viral_Ns3 cd17931
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ...
 31-176 5.11e-04

DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350689 [Multi-domain]  Cd Length: 151  Bit Score: 39.45  E-value: 5.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  31 GETVLLQAPPGAGKTTRVPLALIgaltegQGVLEDHQKIWMIEPrrlaTKAAAARLAESL-GEDIGARIGyAVRGEqkRS 109
Cdd:cd17931    1 GQLTVLDLHPGAGKTTRVLPQII------REAIKKRLRTLVLAP----TRVVAAEMYEALrGLPIRYRTG-AVKEE--HG 67

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 142131821 110 NRTQVEVITDGLFLRRLQSDPSLDGVGCVIFDEFHerGRDADLSLALLREARPLLNPDLAVILMSAT 176
Cdd:cd17931   68 GNEIVDYMCHGTFTCRLLSPKRVPNYNLIIMDEAH--FTDPASIAARGYIHTRVEMGEAAVIFMTAT 132
DEXHc_archSki2 cd18028
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ...
 31-177 3.04e-03

DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350786 [Multi-domain]  Cd Length: 177  Bit Score: 37.31  E-value: 3.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  31 GETVLLQAPPGAGKTTRVPLALIGALTEGQGVL-------------EDHQKiwmieprrlatkaaaarlAESLGEDIGAR 97
Cdd:cd18028   17 GENLLISIPTASGKTLIAEMAMVNTLLEGGKALylvplralasekyEEFKK------------------LEEIGLKVGIS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142131821  98 IGYAVRGEQKRSNRTQVEVITDGL-FLRRlQSDPSLDGVGCVIFDEFH-----ERGRDADLSLALLREarplLNPDLAVI 171
Cdd:cd18028   79 TGDYDEDDEWLGDYDIIVATYEKFdSLLR-HSPSWLRDVGVVVVDEIHlisdeERGPTLESIVARLRR----LNPNTQII 153


                 ....*.
gi 142131821 172 LMSATL 177
Cdd:cd18028  154 GLSATI 159
Dob10 COG4581
Superfamily II RNA helicase [Replication, recombination and repair];
126-177 9.93e-03

Superfamily II RNA helicase [Replication, recombination and repair];


Pssm-ID: 443638 [Multi-domain]  Cd Length: 751  Bit Score: 36.84  E-value: 9.93e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 142131821 126 LQSDPSLDGVGCVIFDEFH---ERGRDADLSLALLrearpLLNPDLAVILMSATL 177
Cdd:COG4581  125 YREGADLEDVGVVVMDEFHylaDPDRGWVWEEPII-----HLPARVQLVLLSATV 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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