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Conserved domains on  [gi|148695781|gb|EDL27728|]
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DEP domain containing 7 [Mus musculus]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138380)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 194-427 7.62e-118

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239870  Cd Length: 235  Bit Score: 346.24  E-value: 7.62e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781 194 LSPQVINEVWQEETIGRLLQLVDLPFLDSLLKQQEVVPKAPQSKRQPDmVNTSNYLDRGILRAYGDSQEDEWISAAIDCL 273
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMDPD-VYTSNYLDREVVKLFSKSQLDHWLLSAMDCL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781 274 EYLPDQMVVDISRNFPEQPDRTDLVKELLFDAIGRYY-STREPLL-NHLYDVHNGIAELLVNGKTEMALEATQLFLKLQD 351
Cdd:cd04405   80 ANWPDQLVVDVSRPLYSQHDMLSGFKRLLFKTIAKYYgQLKEPLLtFHLFDIFVGILELLGNGKEEVALEALQLCLLLLP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148695781 352 SQNREEFRRLLYFMAVAADPSEFKLQEESDNRMVVKRVFSKAIVNNKNVSKGKTDLLVLFLMDHQKDVFKIPAALH 427
Cdd:cd04405  160 PASRRELRRLLRFMARAAKNDMPRLHKEIENRMLVKQTFSRAILCSKDLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP_DEPDC4 cd04446
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ...
 39-133 2.19e-56

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.


:

Pssm-ID: 239893  Cd Length: 95  Bit Score: 182.95  E-value: 2.19e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781  39 WSSIINTLQTQVEVKKRRHHLKRHNDCFVGSEAVDVIYSHLTQNKFFGDVDIPRAKVVRVCQALMDYKVFEAVQTRVFGK 118
Cdd:cd04446    1 WNSIIDALQTQVEVKKRRHNLKSYHDCFLGSEAVDVVLAHLMQNKYFGDVDVPRAKAVRLCQALMDCRVFEAVGTKVFKK 80

                         90
                 ....*....|....*
gi 148695781 119 DKKPTFEDSSCSLYR 133
Cdd:cd04446   81 KKRAVFEDSSSSLYR 95
 
Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 194-427 7.62e-118

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 346.24  E-value: 7.62e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781 194 LSPQVINEVWQEETIGRLLQLVDLPFLDSLLKQQEVVPKAPQSKRQPDmVNTSNYLDRGILRAYGDSQEDEWISAAIDCL 273
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMDPD-VYTSNYLDREVVKLFSKSQLDHWLLSAMDCL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781 274 EYLPDQMVVDISRNFPEQPDRTDLVKELLFDAIGRYY-STREPLL-NHLYDVHNGIAELLVNGKTEMALEATQLFLKLQD 351
Cdd:cd04405   80 ANWPDQLVVDVSRPLYSQHDMLSGFKRLLFKTIAKYYgQLKEPLLtFHLFDIFVGILELLGNGKEEVALEALQLCLLLLP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148695781 352 SQNREEFRRLLYFMAVAADPSEFKLQEESDNRMVVKRVFSKAIVNNKNVSKGKTDLLVLFLMDHQKDVFKIPAALH 427
Cdd:cd04405  160 PASRRELRRLLRFMARAAKNDMPRLHKEIENRMLVKQTFSRAILCSKDLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP_DEPDC4 cd04446
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ...
 39-133 2.19e-56

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.


Pssm-ID: 239893  Cd Length: 95  Bit Score: 182.95  E-value: 2.19e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781  39 WSSIINTLQTQVEVKKRRHHLKRHNDCFVGSEAVDVIYSHLTQNKFFGDVDIPRAKVVRVCQALMDYKVFEAVQTRVFGK 118
Cdd:cd04446    1 WNSIIDALQTQVEVKKRRHNLKSYHDCFLGSEAVDVVLAHLMQNKYFGDVDVPRAKAVRLCQALMDCRVFEAVGTKVFKK 80

                         90
                 ....*....|....*
gi 148695781 119 DKKPTFEDSSCSLYR 133
Cdd:cd04446   81 KKRAVFEDSSSSLYR 95
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 50-134 2.16e-16

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 73.78  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781   50 VEVKKRRHHLKRHNDCFVGSEAVDVIYSHLTqnkffgdvDIPRAKVVRVCQALMDYKVFEAVQtrvfgkDKKPTFEDSSC 129
Cdd:pfam00610   2 VKLKDRRKHLKTYPNCFTGSEAVDWLMDNLE--------IITREEAVELGQLLLDQGLIHHVG------DKHGLFKDSYY 67


                  ....*
gi 148695781  130 sLYRF 134
Cdd:pfam00610  68 -FYRF 71
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 46-136 2.00e-14

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 68.08  E-value: 2.00e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781    46 LQTQVEVKKRRHHLKRHNDCFVGSEAVDVIYSHLTqnkffgdvDIPRAKVVRVCQALMDYKVFEAVQTrvfgkDKKPTFE 125
Cdd:smart00049   1 PETGLKLRDRKYFLKTYPNCFTGSELVDWLMDNLE--------IIDREEAVHLGQLLLDEGLIHHVNG-----PNKHTFK 67

                           90
                   ....*....|.
gi 148695781   126 DSSCsLYRFTT 136
Cdd:smart00049  68 DSKA-LYRFTT 77
 
Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 194-427 7.62e-118

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 346.24  E-value: 7.62e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781 194 LSPQVINEVWQEETIGRLLQLVDLPFLDSLLKQQEVVPKAPQSKRQPDmVNTSNYLDRGILRAYGDSQEDEWISAAIDCL 273
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMDPD-VYTSNYLDREVVKLFSKSQLDHWLLSAMDCL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781 274 EYLPDQMVVDISRNFPEQPDRTDLVKELLFDAIGRYY-STREPLL-NHLYDVHNGIAELLVNGKTEMALEATQLFLKLQD 351
Cdd:cd04405   80 ANWPDQLVVDVSRPLYSQHDMLSGFKRLLFKTIAKYYgQLKEPLLtFHLFDIFVGILELLGNGKEEVALEALQLCLLLLP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148695781 352 SQNREEFRRLLYFMAVAADPSEFKLQEESDNRMVVKRVFSKAIVNNKNVSKGKTDLLVLFLMDHQKDVFKIPAALH 427
Cdd:cd04405  160 PASRRELRRLLRFMARAAKNDMPRLHKEIENRMLVKQTFSRAILCSKDLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP_DEPDC4 cd04446
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ...
 39-133 2.19e-56

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.


Pssm-ID: 239893  Cd Length: 95  Bit Score: 182.95  E-value: 2.19e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781  39 WSSIINTLQTQVEVKKRRHHLKRHNDCFVGSEAVDVIYSHLTQNKFFGDVDIPRAKVVRVCQALMDYKVFEAVQTRVFGK 118
Cdd:cd04446    1 WNSIIDALQTQVEVKKRRHNLKSYHDCFLGSEAVDVVLAHLMQNKYFGDVDVPRAKAVRLCQALMDCRVFEAVGTKVFKK 80

                         90
                 ....*....|....*
gi 148695781 119 DKKPTFEDSSCSLYR 133
Cdd:cd04446   81 KKRAVFEDSSSSLYR 95
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 50-134 2.16e-16

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 73.78  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781   50 VEVKKRRHHLKRHNDCFVGSEAVDVIYSHLTqnkffgdvDIPRAKVVRVCQALMDYKVFEAVQtrvfgkDKKPTFEDSSC 129
Cdd:pfam00610   2 VKLKDRRKHLKTYPNCFTGSEAVDWLMDNLE--------IITREEAVELGQLLLDQGLIHHVG------DKHGLFKDSYY 67


                  ....*
gi 148695781  130 sLYRF 134
Cdd:pfam00610  68 -FYRF 71
DEP cd04371
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ...
 46-133 4.85e-15

DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction.


Pssm-ID: 239836  Cd Length: 81  Bit Score: 70.06  E-value: 4.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781  46 LQTQVEVKKRRHHLKRHNDCFVGSEAVDVIYSHLTqnkffgdvDIPRAKVVRVCQALMDYKVFEAVQtrvfgkDKKPTFE 125
Cdd:cd04371    9 SDSGVPIKDRKYHLKTYPNCFTGSELVDWLLDNLE--------AITREEAVELGQALLKHGLIHHVS------DDKHTFR 74


                 ....*...
gi 148695781 126 DSSCsLYR 133
Cdd:cd04371   75 DSYA-LYR 81
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 46-136 2.00e-14

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 68.08  E-value: 2.00e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781    46 LQTQVEVKKRRHHLKRHNDCFVGSEAVDVIYSHLTqnkffgdvDIPRAKVVRVCQALMDYKVFEAVQTrvfgkDKKPTFE 125
Cdd:smart00049   1 PETGLKLRDRKYFLKTYPNCFTGSELVDWLMDNLE--------IIDREEAVHLGQLLLDEGLIHHVNG-----PNKHTFK 67

                           90
                   ....*....|.
gi 148695781   126 DSSCsLYRFTT 136
Cdd:smart00049  68 DSKA-LYRFTT 77
DEP_BRCC3 cd04447
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ...
 38-134 2.58e-08

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function.


Pssm-ID: 239894  Cd Length: 92  Bit Score: 51.38  E-value: 2.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781  38 VWSSIINTLQTQVEVKKRRHHLKRHNDCFVGSEAVDVIYSHLTQNKFFGDvDIPRAKVVRVCQALMDYKVFEAVQtrvfG 117
Cdd:cd04447    2 LWNEVTELFRAGMPLRKHRQHFKSYENCFTASEAVDWLHELLRSNSNFGP-EVTRQQTVQLLKKFLKNHVIEDIK----G 76

                         90
                 ....*....|....*..
gi 148695781 118 KDKKPTFEDSScSLYRF 134
Cdd:cd04447   77 RWGKEDLEDNN-HLYRF 92
DEP_Epac cd04437
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange ...
 52-135 2.01e-06

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by cyclic AMP, a second messenger that plays a role in the control of diverse cellular processes, such as cell adhesion and insulin secretion. Epac-like proteins share a common domain architecture, containing RasGEF, DEP and CAP-effector (cAMP binding) domains. The DEP domain is involved in membrane localization.


Pssm-ID: 239884  Cd Length: 125  Bit Score: 46.95  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781  52 VKKRRHHLKRHNDCFVGSEAVD--VIYSHLTQNkffgdvdipRAKVVRVCQALMDykvfEAVQTRVfgkDKKPTFEDsSC 129
Cdd:cd04437   17 IRDRKYHLRTYRQCCVGTELVDwlLQQSPCVQS---------RSQAVGMWQVLLE----EGVLLHV---DQELHFQD-KY 79


                 ....*.
gi 148695781 130 SLYRFT 135
Cdd:cd04437   80 QFYRFS 85
DEP_1_DEP6 cd04442
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins ...
 52-134 1.51e-05

DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.


Pssm-ID: 239889 [Multi-domain]  Cd Length: 82  Bit Score: 43.34  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781  52 VKKRRHHLKRHNDCFVGSEAVDVIYSHLTQNKffgdvdipRAKVVRVCQALMDYKVFEAVQtrvfgkDKKPTFEDSSCsL 131
Cdd:cd04442   15 IKDRRHHLRTYPNCFVGKELIDWLIEHKEASD--------RETAIKIMQKLLDHSIIHHVC------DEHKEFKDAKL-F 79


                 ...
gi 148695781 132 YRF 134
Cdd:cd04442   80 YRF 82
DEP_PIKfyve cd04448
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange ...
 38-111 3.57e-03

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol phosphate kinase) domain. PIKfyve-like proteins are important phosphatidylinositol (3)-monophosphate (PtdIns(3)P)-5-kinases, producing PtdIns(3,5)P2, which plays a major role in multivesicular body (MVB) sorting and control of retrograde traffic from the vacuole back to the endosome and/or Golgi. PIKfyve itself has been shown to be play a role in regulating early-endosome-to-trans-Golgi network (TGN) retrograde trafficking.


Pssm-ID: 239895  Cd Length: 81  Bit Score: 36.65  E-value: 3.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148695781  38 VWSSIINTlQTQVEVKKRRHHLKRHNDCFVGSEAVDVIyshLTQNKFfgdvdIPRAKVVRVCQALMDYKVFEAV 111
Cdd:cd04448    2 LWEKICRS-STGIEFQDHRYRLRTYTNCILGKELVNWL---IRQGKA-----ATRVQAIAIGQALLDAGWIECV 66
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 314-426 7.18e-03

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 37.83  E-value: 7.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695781 314 EPLLNHL-YDVHNGIAELLVNG---------KTEMALEATQLFLKLQDSQNREEFR---RLLYFMAvaadpsefklQEES 380
Cdd:cd04392   77 EPLLTHAhYPAHLQIADLCQFDekgnktsapDKERLLEALQLLLLLLPEENRNLLKlilDLLYQTA----------KHED 146

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148695781 381 DNRMV---VKRVFSKAIVNNKNVSKG-------KTDLLVLFLMDHQKDVFKIPAAL 426
Cdd:cd04392  147 KNKMSadnLALLFTPHLICPRNLTPEdlhenaqKLNSIVTFMIKHSQKLFKAPAYL 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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