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Conserved domains on  [gi|149030997|gb|EDL86024|]
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p53 and DNA damage regulated 1, isoform CRA_c [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDRG1 cd22860
p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a ...
 9-86 2.76e-25

p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a beta-type subunit of the prefoldin-like complex that is part of the PAQosome (Particle for Arrangement of Quaternary structure) complex. The PAQosome is a cochaperone that assists the chaperone HSP90 in assembly of large protein complexes. PDRG1 acts as a tumor marker in multiple cancer types, including testicular cancer, lung cancer, colorectal cancer, liver cancer, etc. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related.


:

Pssm-ID: 467471  Cd Length: 103  Bit Score: 91.04  E-value: 2.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030997   9 VLRYLVEVEELAEAVLSDKRQIVDLDTKRNQNREGLRALQKDPSVS-------------------------DQEHLDKEI 63
Cdd:cd22860    1 LLEYLAEVEELAEEILTDKQELVDLDRRRNKNREALRALKKSKKEEskvwiclgdmfiklpkekakkmlekDQKELDKEI 80

                         90       100
                 ....*....|....*....|...
gi 149030997  64 ERLRSQLKVKVNRLLEAQGKPEL 86
Cdd:cd22860   81 NKLRSELKEKVNKLRDLEGKPEL 103
 
Name Accession Description Interval E-value
PDRG1 cd22860
p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a ...
 9-86 2.76e-25

p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a beta-type subunit of the prefoldin-like complex that is part of the PAQosome (Particle for Arrangement of Quaternary structure) complex. The PAQosome is a cochaperone that assists the chaperone HSP90 in assembly of large protein complexes. PDRG1 acts as a tumor marker in multiple cancer types, including testicular cancer, lung cancer, colorectal cancer, liver cancer, etc. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related.


Pssm-ID: 467471  Cd Length: 103  Bit Score: 91.04  E-value: 2.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030997   9 VLRYLVEVEELAEAVLSDKRQIVDLDTKRNQNREGLRALQKDPSVS-------------------------DQEHLDKEI 63
Cdd:cd22860    1 LLEYLAEVEELAEEILTDKQELVDLDRRRNKNREALRALKKSKKEEskvwiclgdmfiklpkekakkmlekDQKELDKEI 80

                         90       100
                 ....*....|....*....|...
gi 149030997  64 ERLRSQLKVKVNRLLEAQGKPEL 86
Cdd:cd22860   81 NKLRSELKEKVNKLRDLEGKPEL 103
 
Name Accession Description Interval E-value
PDRG1 cd22860
p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a ...
 9-86 2.76e-25

p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a beta-type subunit of the prefoldin-like complex that is part of the PAQosome (Particle for Arrangement of Quaternary structure) complex. The PAQosome is a cochaperone that assists the chaperone HSP90 in assembly of large protein complexes. PDRG1 acts as a tumor marker in multiple cancer types, including testicular cancer, lung cancer, colorectal cancer, liver cancer, etc. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related.


Pssm-ID: 467471  Cd Length: 103  Bit Score: 91.04  E-value: 2.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030997   9 VLRYLVEVEELAEAVLSDKRQIVDLDTKRNQNREGLRALQKDPSVS-------------------------DQEHLDKEI 63
Cdd:cd22860    1 LLEYLAEVEELAEEILTDKQELVDLDRRRNKNREALRALKKSKKEEskvwiclgdmfiklpkekakkmlekDQKELDKEI 80

                         90       100
                 ....*....|....*....|...
gi 149030997  64 ERLRSQLKVKVNRLLEAQGKPEL 86
Cdd:cd22860   81 NKLRSELKEKVNKLRDLEGKPEL 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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