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Conserved domains on  [gi|149046994|gb|EDL99742|]
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rCG58575, partial [Rattus norvegicus]

Protein Classification

YHS family protein( domain architecture ID 10007244)

YHS family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 57-112 2.62e-07

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


:

Pssm-ID: 442578  Cd Length: 56  Bit Score: 43.93  E-value: 2.62e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 149046994  57 GDTKHFCPVVlkeNFVLQPGSTEEAVKYREKIYYFSTPEAKEKFLEHPEDYVSQNE 112
Cdd:COG3350    3 GVAMVIDPVC---GMTVDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
 
Name Accession Description Interval E-value
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 57-112 2.62e-07

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 43.93  E-value: 2.62e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 149046994  57 GDTKHFCPVVlkeNFVLQPGSTEEAVKYREKIYYFSTPEAKEKFLEHPEDYVSQNE 112
Cdd:COG3350    3 GVAMVIDPVC---GMTVDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 62-108 1.38e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 36.48  E-value: 1.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 149046994   62 FCPVVL-KENFVLQPGSTEEAV-KYREKIYYFSTPEAKEKFLEHPEDYV 108
Cdd:pfam12018 201 FCAWTLvVRDGLLLPGNPSIGVlKYKDKYYAFSSKEAAYEFASDPDRFI 249
 
Name Accession Description Interval E-value
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 57-112 2.62e-07

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 43.93  E-value: 2.62e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 149046994  57 GDTKHFCPVVlkeNFVLQPGSTEEAVKYREKIYYFSTPEAKEKFLEHPEDYVSQNE 112
Cdd:COG3350    3 GVAMVIDPVC---GMTVDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 62-108 1.38e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 36.48  E-value: 1.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 149046994   62 FCPVVL-KENFVLQPGSTEEAV-KYREKIYYFSTPEAKEKFLEHPEDYV 108
Cdd:pfam12018 201 FCAWTLvVRDGLLLPGNPSIGVlKYKDKYYAFSSKEAAYEFASDPDRFI 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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