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Conserved domains on  [gi|149049566|gb|EDM02020|]
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similar to Tubulin alpha-8 chain (Alpha-tubulin 8) [Rattus norvegicus]

Protein Classification

FtsZ/tubulin family protein( domain architecture ID 3)

FtsZ/tubulin family protein may be involved in polymer formation, similar to the cell-division GTPase FtsZ or the tubulin-like filament-forming GTPase TubZ

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin_FtsZ_Cetz-like super family cl10017
Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, ...
 2-126 1.20e-86

Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, gamma-, delta-, epsilon, and zeta-tubulins as well as FtsZ and CetZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. A recent study found that CetZ proteins, formerly annotated FtsZ type 2, are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development.


The actual alignment was detected with superfamily member cd02186:

Pssm-ID: 471962 [Multi-domain]  Cd Length: 434  Bit Score: 262.86  E-value: 1.20e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   2 RECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKINDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAG 81
Cdd:cd02186    1 REIISIHVGQAGVQIGNACWELFCLEHGIQPDGQMPSDKTIGGDDDNFNTFFSETGSGKYVPRAVFVDLEPTVIDEIRTG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 149049566  82 TYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:cd02186   81 PYRQLFHPEQLISGKEDAANNFARGYYTIGKEIIDPVLDRIRKLA 125
PTZ00335 super family cl30503
tubulin alpha chain; Provisional
 126-212 8.58e-63

tubulin alpha chain; Provisional


The actual alignment was detected with superfamily member PTZ00335:

Pssm-ID: 185562 [Multi-domain]  Cd Length: 448  Bit Score: 201.86  E-value: 8.58e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566 126 VGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDY 205
Cdd:PTZ00335 353 CGINYQPPTVVPGGDLAKVQRAVCMISNSTAIAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDY 432


                 ....*..
gi 149049566 206 EEVGTDS 212
Cdd:PTZ00335 433 EEVGAES 439
 
Name Accession Description Interval E-value
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 2-126 1.20e-86

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 262.86  E-value: 1.20e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   2 RECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKINDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAG 81
Cdd:cd02186    1 REIISIHVGQAGVQIGNACWELFCLEHGIQPDGQMPSDKTIGGDDDNFNTFFSETGSGKYVPRAVFVDLEPTVIDEIRTG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 149049566  82 TYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:cd02186   81 PYRQLFHPEQLISGKEDAANNFARGYYTIGKEIIDPVLDRIRKLA 125
PTZ00335 PTZ00335
tubulin alpha chain; Provisional
 1-126 2.64e-86

tubulin alpha chain; Provisional


Pssm-ID: 185562 [Multi-domain]  Cd Length: 448  Bit Score: 262.34  E-value: 2.64e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   1 MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKINDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRA 80
Cdd:PTZ00335   1 MREVISIHIGQAGIQVGNACWELFCLEHGIQPDGQMPSDKNIGVEDDAFNTFFSETGAGKHVPRCVFLDLEPTVIDEVRT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 149049566  81 GTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:PTZ00335  81 GTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLA 126
PTZ00335 PTZ00335
tubulin alpha chain; Provisional
 126-212 8.58e-63

tubulin alpha chain; Provisional


Pssm-ID: 185562 [Multi-domain]  Cd Length: 448  Bit Score: 201.86  E-value: 8.58e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566 126 VGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDY 205
Cdd:PTZ00335 353 CGINYQPPTVVPGGDLAKVQRAVCMISNSTAIAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDY 432


                 ....*..
gi 149049566 206 EEVGTDS 212
Cdd:PTZ00335 433 EEVGAES 439
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 126-208 6.21e-59

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 191.21  E-value: 6.21e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566 126 VGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDY 205
Cdd:cd02186  352 VGINYQPPTVVPGSDLAKVDRSVCMLANSTAIAEAFQRLDHKFDLLYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDY 431


                 ...
gi 149049566 206 EEV 208
Cdd:cd02186  432 EEV 434
Tubulin pfam00091
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ...
 3-126 8.43e-41

Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.


Pssm-ID: 459669 [Multi-domain]  Cd Length: 190  Bit Score: 137.73  E-value: 8.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566    3 ECISVHVGQAGVQIGNACWELFCLEHGIqadgtfgtqaskinddDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAGt 82
Cdd:pfam00091   1 EIIVIGVGGAGNNIGNALWELLCLEHGI----------------DSLNVFFSESGSVEFIPRSLAIDTDPQALNEIKAG- 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 149049566   83 yrqlFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:pfam00091  64 ----FNPNKILLGKEGTGGNGAGGYPEIGREAAEESLEEIRKEV 103
Tubulin_C pfam03953
Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. ...
 126-165 8.13e-12

Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).


Pssm-ID: 397858 [Multi-domain]  Cd Length: 125  Bit Score: 60.32  E-value: 8.13e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 149049566  126 VGINYQPPTVVPGGDlakvqRAVCMLSNTTAIAEAWARLD 165
Cdd:pfam03953  91 VAICSQSPYVVPGSK-----VSGLMLANTTSIAELFQRLL 125
 
Name Accession Description Interval E-value
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 2-126 1.20e-86

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 262.86  E-value: 1.20e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   2 RECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKINDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAG 81
Cdd:cd02186    1 REIISIHVGQAGVQIGNACWELFCLEHGIQPDGQMPSDKTIGGDDDNFNTFFSETGSGKYVPRAVFVDLEPTVIDEIRTG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 149049566  82 TYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:cd02186   81 PYRQLFHPEQLISGKEDAANNFARGYYTIGKEIIDPVLDRIRKLA 125
PTZ00335 PTZ00335
tubulin alpha chain; Provisional
 1-126 2.64e-86

tubulin alpha chain; Provisional


Pssm-ID: 185562 [Multi-domain]  Cd Length: 448  Bit Score: 262.34  E-value: 2.64e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   1 MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKINDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRA 80
Cdd:PTZ00335   1 MREVISIHIGQAGIQVGNACWELFCLEHGIQPDGQMPSDKNIGVEDDAFNTFFSETGAGKHVPRCVFLDLEPTVIDEVRT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 149049566  81 GTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:PTZ00335  81 GTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLA 126
PLN00221 PLN00221
tubulin alpha chain; Provisional
 1-126 1.29e-82

tubulin alpha chain; Provisional


Pssm-ID: 177802  Cd Length: 450  Bit Score: 252.81  E-value: 1.29e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   1 MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKINDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRA 80
Cdd:PLN00221   1 MRECISIHIGQAGIQVGNACWELYCLEHGIQPDGQMPSDKTVGGGDDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 149049566  81 GTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:PLN00221  81 GTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLA 126
PTZ00335 PTZ00335
tubulin alpha chain; Provisional
 126-212 8.58e-63

tubulin alpha chain; Provisional


Pssm-ID: 185562 [Multi-domain]  Cd Length: 448  Bit Score: 201.86  E-value: 8.58e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566 126 VGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDY 205
Cdd:PTZ00335 353 CGINYQPPTVVPGGDLAKVQRAVCMISNSTAIAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDY 432


                 ....*..
gi 149049566 206 EEVGTDS 212
Cdd:PTZ00335 433 EEVGAES 439
PLN00221 PLN00221
tubulin alpha chain; Provisional
 127-212 3.97e-60

tubulin alpha chain; Provisional


Pssm-ID: 177802  Cd Length: 450  Bit Score: 195.03  E-value: 3.97e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566 127 GINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYE 206
Cdd:PLN00221 354 GINYQPPTVVPGGDLAKVQRAVCMISNSTAVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYE 433


                 ....*.
gi 149049566 207 EVGTDS 212
Cdd:PLN00221 434 EVGAES 439
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 126-208 6.21e-59

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 191.21  E-value: 6.21e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566 126 VGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDY 205
Cdd:cd02186  352 VGINYQPPTVVPGSDLAKVDRSVCMLANSTAIAEAFQRLDHKFDLLYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDY 431


                 ...
gi 149049566 206 EEV 208
Cdd:cd02186  432 EEV 434
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 2-126 1.72e-44

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 153.49  E-value: 1.72e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   2 RECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKINDddSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAG 81
Cdd:cd02187    1 REIIHIQIGQCGNQIGAKFWETISKEHGIDPDGTYKGDSDLQLE--RINVYFNEASGGKYVPRAVLVDLEPGTIDSVRSG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 149049566  82 TYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:cd02187   79 PYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEA 123
Tubulin pfam00091
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ...
 3-126 8.43e-41

Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.


Pssm-ID: 459669 [Multi-domain]  Cd Length: 190  Bit Score: 137.73  E-value: 8.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566    3 ECISVHVGQAGVQIGNACWELFCLEHGIqadgtfgtqaskinddDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAGt 82
Cdd:pfam00091   1 EIIVIGVGGAGNNIGNALWELLCLEHGI----------------DSLNVFFSESGSVEFIPRSLAIDTDPQALNEIKAG- 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 149049566   83 yrqlFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:pfam00091  64 ----FNPNKILLGKEGTGGNGAGGYPEIGREAAEESLEEIRKEV 103
PTZ00010 PTZ00010
tubulin beta chain; Provisional
 1-124 5.51e-40

tubulin beta chain; Provisional


Pssm-ID: 240228 [Multi-domain]  Cd Length: 445  Bit Score: 142.22  E-value: 5.51e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   1 MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTF----GTQASKINdddsftTFFSETGNGKHVPRAVMVDLEPTVVD 76
Cdd:PTZ00010   1 MREIVHIQAGQCGNQIGSKFWEVISDEHGIDPTGTYqgdsDLQLERIN------VYYNEATGGRYVPRAVLMDLEPGTMD 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 149049566  77 EVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRK 124
Cdd:PTZ00010  75 SVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVVRK 122
PLN00220 PLN00220
tubulin beta chain; Provisional
 1-124 3.14e-36

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 132.25  E-value: 3.14e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   1 MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTF----GTQASKINdddsftTFFSETGNGKHVPRAVMVDLEPTVVD 76
Cdd:PLN00220   1 MREILHIQGGQCGNQIGAKFWEVVCDEHGIDPTGTYhgdsDLQLERIN------VYYNEASGGRYVPRAVLMDLEPGTMD 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 149049566  77 EVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRK 124
Cdd:PLN00220  75 SVRSGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRK 122
gamma_tubulin cd02188
The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of ...
 2-124 1.34e-34

The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping.


Pssm-ID: 276957 [Multi-domain]  Cd Length: 430  Bit Score: 127.27  E-value: 1.34e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   2 RECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKINDDDSftTFFSETGNGKHVPRAVMVDLEPTVVDEVRAG 81
Cdd:cd02188    1 REIITLQVGQCGNQIGSEFWKQLCSEHGISPDGSLEDFATDGNDRKD--VFFYQADDEHYIPRAILLDLEPRVINSIQNS 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 149049566  82 TYRQLFHPEQLITGKED--AANNYARGhYTVGKESIDLVLDRIRK 124
Cdd:cd02188   79 PYKNLFNPENIYLSKEGggAGNNWASG-YSQGEKVQEEILDIIDR 122
Tubulin cd06059
The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct ...
 3-126 3.12e-33

The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology.


Pssm-ID: 276963 [Multi-domain]  Cd Length: 387  Bit Score: 123.08  E-value: 3.12e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   3 ECISVHVGQAGVQIGNACWELFclehgiqadgtfgtqaskindddsfttffsetgngkhvpRAVMVDLEPTVVDEVRAGT 82
Cdd:cd06059    1 EIITIQVGQCGNQIGDRFWELA---------------------------------------RAVLVDMEEGVINEVLKGP 41

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 149049566  83 YRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:cd06059   42 LGQLFDPNQFVTGVSGAGNNWAVGYYVYGPKYIESILDRIRKQV 85
PLN00222 PLN00222
tubulin gamma chain; Provisional
 2-122 7.58e-27

tubulin gamma chain; Provisional


Pssm-ID: 215108 [Multi-domain]  Cd Length: 454  Bit Score: 106.47  E-value: 7.58e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   2 RECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASkiNDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAG 81
Cdd:PLN00222   3 REIITLQVGQCGNQIGMEFWKQLCLEHGISKDGILEDFAT--QGGDRKDVFFYQADDEHYIPRALLIDLEPRVINGIQNS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 149049566  82 TYRQLFHPEQLITGKE--DAANNYARGhYTVGKESIDLVLDRI 122
Cdd:PLN00222  81 EYRNLYNHENIFVSDHggGAGNNWASG-YHQGEQVEEDIMDMI 122
Tubulin cd06059
The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct ...
 68-207 8.39e-27

The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology.


Pssm-ID: 276963 [Multi-domain]  Cd Length: 387  Bit Score: 105.75  E-value: 8.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566  68 VDLEPTVVDEVRagtyRQLFHPEQ------LITGKEDAANNYARGHYtVGKESIDLVLDRIRK------------LVGIN 129
Cdd:cd06059  243 VTLEPLTLDQLF----SDLFSKDNqlvgcdPRHGTYLACALLLRGKV-FSLSDVRRNIDRIKPklkfiswnpdgfKVGLC 317

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149049566 130 YQPPtvvpggdlAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEE 207
Cdd:cd06059  318 SVPP--------VGQKYSLLFLSNNTSIASTFERLIERFDKLYKRKAFLHHYTGEGMEEGDFSEARESLANLIQEYQE 387
Tubulin_FtsZ_Cetz-like cd00286
Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, ...
 3-126 1.48e-24

Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, gamma-, delta-, epsilon, and zeta-tubulins as well as FtsZ and CetZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. A recent study found that CetZ proteins, formerly annotated FtsZ type 2, are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development.


Pssm-ID: 276954 [Multi-domain]  Cd Length: 332  Bit Score: 98.63  E-value: 1.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   3 ECISVHVGQAGVQIGNACWELfclehgiqadgtfgtqaskindddsfttffsetgngkhvprAVMVDLEPTVVDEVRAGT 82
Cdd:cd00286    1 EIVTIQVGQCGNQIGAAFWEQ-----------------------------------------AVLVDLEPAVLDELLSGP 39

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 149049566  83 YRQLFHPEQLITGKED--AANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:cd00286   40 LRQLFHPENIILIQKYhgAGNNWAKGHSVAGEEYQEEILDAIRKEV 85
delta_zeta_tubulin-like cd02189
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ...
 4-126 9.87e-23

The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.


Pssm-ID: 276958 [Multi-domain]  Cd Length: 433  Bit Score: 95.03  E-value: 9.87e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   4 CISVHVGQAGVQIGNACWELFCLEhgiqadgtFGTQASKINDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAGTY 83
Cdd:cd02189    2 IVTVQVGQCGNQLGDELFDTLADE--------ADSSASEGDQNSSATRFFSPFSDGKLKARCVLVDMEPKVVQQVLSRAR 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 149049566  84 RQLFH--PEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:cd02189   74 SGAWSydPKNVVCGQSGSGNNWALGYYVHGPSLLEDILEALRREA 118
epsilon_tubulin cd02190
The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the ...
 2-126 4.02e-22

The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not ubiquitous among eukaryotes play a role in basal body/centriole morphogenesis.


Pssm-ID: 276959 [Multi-domain]  Cd Length: 449  Bit Score: 93.46  E-value: 4.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   2 RECISVHVGQAGVQIGNACWELFCLEHGI-QADGTFgtqaskindDDSFTTFFSETGNGKHVP-------------RAVM 67
Cdd:cd02190    1 REIITVQVGQCGNQIGCRFWDLALREHAAyNKDGVY---------DDSMSSFFRNVDTRSGDPgddggspikslkaRAVL 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 149049566  68 VDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:cd02190   72 IDMEEGVVNELLKGPLGDLFDETQLVTDVSGAGNNWAHGYHEYGPQYGESILEKLRRAA 130
PTZ00387 PTZ00387
epsilon tubulin; Provisional
 1-126 1.17e-20

epsilon tubulin; Provisional


Pssm-ID: 240395 [Multi-domain]  Cd Length: 465  Bit Score: 89.40  E-value: 1.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566   1 MRECISVHVGQAGVQIGNACWELFCLEH-GIQADGTFgtqaskindDDSFTTFFSETGNGKHVP-------RAVMVDLEP 72
Cdd:PTZ00387   1 PREIVTVQVGQCGNQLGHRFWDVALKEHkKINANPQY---------DDARDSFFENVSENVNRPgkenlkaRAVLVDMEE 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 149049566  73 TVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLV 126
Cdd:PTZ00387  72 GVLNQILKSPLGDLFDENFFVSDVSGAGNNWAVGHMEYGDKYIDSISESVRRQV 125
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 83-207 2.01e-17

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 79.92  E-value: 2.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149049566  83 YRQLFHPEQLItgkedAANNYARGHY-TV-----GKESIDLVLDRIRKLVGIN-YQPPTVVPGGdlakVQRAVC------ 149
Cdd:cd02187  289 TQQLFDAKNMM-----AACDPRHGRYlTAaaifrGRISTKEVDEQMSKVQNKNsSYFVEWIPNN----VKTSVCdipprg 359

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 149049566 150 ------MLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEE 207
Cdd:cd02187  360 lkmsatFIGNSTAIQELFKRLSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNLNDLISEYQQ 423
PTZ00010 PTZ00010
tubulin beta chain; Provisional
 144-212 1.45e-13

tubulin beta chain; Provisional


Pssm-ID: 240228 [Multi-domain]  Cd Length: 445  Bit Score: 68.65  E-value: 1.45e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149049566 144 VQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAR---EDLAALEKDYEEVGTDS 212
Cdd:PTZ00010 361 LKMSVTFIGNSTAIQEMFRRVGEQFTAMFRRKAFLHWYTGEGMDEMEFTEAEsnmNDLVSEYQQYQDATVEE 432
PLN00220 PLN00220
tubulin beta chain; Provisional
 153-207 1.60e-13

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 68.70  E-value: 1.60e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 149049566 153 NTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEE 207
Cdd:PLN00220 370 NSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQ 424
Tubulin_C pfam03953
Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. ...
 126-165 8.13e-12

Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).


Pssm-ID: 397858 [Multi-domain]  Cd Length: 125  Bit Score: 60.32  E-value: 8.13e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 149049566  126 VGINYQPPTVVPGGDlakvqRAVCMLSNTTAIAEAWARLD 165
Cdd:pfam03953  91 VAICSQSPYVVPGSK-----VSGLMLANTTSIAELFQRLL 125
epsilon_tubulin cd02190
The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the ...
 150-208 1.75e-10

The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not ubiquitous among eukaryotes play a role in basal body/centriole morphogenesis.


Pssm-ID: 276959 [Multi-domain]  Cd Length: 449  Bit Score: 59.56  E-value: 1.75e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 149049566 150 MLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVgEGMEEGEFSEAREDLAALEKDYEEV 208
Cdd:cd02190  392 CLANNTCIKPTFTEMHERFDKLYKRKAHLHHYT-QYMEQDDFDEALESLLDLIEEYKDL 449
delta_zeta_tubulin-like cd02189
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ...
 143-207 6.79e-07

The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.


Pssm-ID: 276958 [Multi-domain]  Cd Length: 433  Bit Score: 49.19  E-value: 6.79e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149049566 143 KVQRAVCMLSNTTAIAeawARLDH---KFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEE 207
Cdd:cd02189  369 GYEKSVTLLSNSQNIV---GPLDSlleKAWQMFKAGAYLHQYEKYGVEEEDFLDAFATLEQIIAAYKS 433
gamma_tubulin cd02188
The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of ...
 150-205 8.16e-06

The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping.


Pssm-ID: 276957 [Multi-domain]  Cd Length: 430  Bit Score: 46.00  E-value: 8.16e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 149049566 150 MLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEG---EFSEAREDLAALEKDY 205
Cdd:cd02188  372 MLANHTSISSLFEKILSQYDKLRKRNAFLENYRKEDMFQDnleEFDESREVVQSLIDEY 430
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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