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Conserved domains on  [gi|149065991|gb|EDM15864|]
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interleukin 2 receptor, beta chain [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL2RB_N1 pfam18707
Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I ...
 32-124 2.39e-40

Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I cytokine receptor superfamily. It carries a cytokine-binding homology region, which is divided in two fibronectin type-III (FN-III) domains termed D1 and D2. Each domain contains seven beta-strands that form a sandwich of two antiparallel beta-sheets. The N-terminal D1 domain of IL-2Rbeta includes two highly conserved disulfide bridges. This entry describes D1 of the N-terminal region of IL2Rbeta.


:

Pssm-ID: 465844  Cd Length: 92  Bit Score: 139.83  E-value: 2.39e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149065991   32 SHLKCFYNSRANVSCMWSPEEALNVTSCHIHAKSDMRHWNKTCELTPVRQASWACNLILGPlPDSQSLTSVDLLSLSVVC 111
Cdd:pfam18707   1 SSLTCFYNSRANISCVWSHDGTLQVTSCHLHAKSNIRSWNKSCELIPVEPASWSCNLILGS-PNSQKFTSADTLDLSVMC 79

                          90
                  ....*....|...
gi 149065991  112 WEEKGWRRVKTCN 124
Cdd:pfam18707  80 SEGEEWRGVKTQD 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 135-216 1.72e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149065991   135 APHSLQVLHIETRRCNISWEVSQVSHYVNPYLEFEARRRLLDRSWEDASVfslKQRQQWIFLETLTPDTSYELQVRVIAQ 214
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNV---TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ..
gi 149065991   215 RG 216
Cdd:smart00060  80 AG 81
 
Name Accession Description Interval E-value
IL2RB_N1 pfam18707
Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I ...
 32-124 2.39e-40

Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I cytokine receptor superfamily. It carries a cytokine-binding homology region, which is divided in two fibronectin type-III (FN-III) domains termed D1 and D2. Each domain contains seven beta-strands that form a sandwich of two antiparallel beta-sheets. The N-terminal D1 domain of IL-2Rbeta includes two highly conserved disulfide bridges. This entry describes D1 of the N-terminal region of IL2Rbeta.


Pssm-ID: 465844  Cd Length: 92  Bit Score: 139.83  E-value: 2.39e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149065991   32 SHLKCFYNSRANVSCMWSPEEALNVTSCHIHAKSDMRHWNKTCELTPVRQASWACNLILGPlPDSQSLTSVDLLSLSVVC 111
Cdd:pfam18707   1 SSLTCFYNSRANISCVWSHDGTLQVTSCHLHAKSNIRSWNKSCELIPVEPASWSCNLILGS-PNSQKFTSADTLDLSVMC 79

                          90
                  ....*....|...
gi 149065991  112 WEEKGWRRVKTCN 124
Cdd:pfam18707  80 SEGEEWRGVKTQD 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 135-216 1.72e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149065991   135 APHSLQVLHIETRRCNISWEVSQVSHYVNPYLEFEARRRLLDRSWEDASVfslKQRQQWIFLETLTPDTSYELQVRVIAQ 214
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNV---TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ..
gi 149065991   215 RG 216
Cdd:smart00060  80 AG 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 135-232 3.87e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 3.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149065991 135 APHSLQVLHIETRRCNISWEV-----SQVSHYVnpyLEFearRRLLDRSWEDASVFSLKQRQqwIFLETLTPDTSYELQV 209
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPpeddgGPITGYV---VEY---REKGSGDWKEVEVTPGSETS--YTLTGLKPGTEYEFRV 74

                         90       100
                 ....*....|....*....|...
gi 149065991 210 RVIAQRGktrtWSPWSQPMAFRT 232
Cdd:cd00063   75 RAVNGGG----ESPPSESVTVTT 93
 
Name Accession Description Interval E-value
IL2RB_N1 pfam18707
Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I ...
 32-124 2.39e-40

Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I cytokine receptor superfamily. It carries a cytokine-binding homology region, which is divided in two fibronectin type-III (FN-III) domains termed D1 and D2. Each domain contains seven beta-strands that form a sandwich of two antiparallel beta-sheets. The N-terminal D1 domain of IL-2Rbeta includes two highly conserved disulfide bridges. This entry describes D1 of the N-terminal region of IL2Rbeta.


Pssm-ID: 465844  Cd Length: 92  Bit Score: 139.83  E-value: 2.39e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149065991   32 SHLKCFYNSRANVSCMWSPEEALNVTSCHIHAKSDMRHWNKTCELTPVRQASWACNLILGPlPDSQSLTSVDLLSLSVVC 111
Cdd:pfam18707   1 SSLTCFYNSRANISCVWSHDGTLQVTSCHLHAKSNIRSWNKSCELIPVEPASWSCNLILGS-PNSQKFTSADTLDLSVMC 79

                          90
                  ....*....|...
gi 149065991  112 WEEKGWRRVKTCN 124
Cdd:pfam18707  80 SEGEEWRGVKTQD 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 135-216 1.72e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149065991   135 APHSLQVLHIETRRCNISWEVSQVSHYVNPYLEFEARRRLLDRSWEDASVfslKQRQQWIFLETLTPDTSYELQVRVIAQ 214
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNV---TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ..
gi 149065991   215 RG 216
Cdd:smart00060  80 AG 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 135-232 3.87e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 3.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149065991 135 APHSLQVLHIETRRCNISWEV-----SQVSHYVnpyLEFearRRLLDRSWEDASVFSLKQRQqwIFLETLTPDTSYELQV 209
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPpeddgGPITGYV---VEY---REKGSGDWKEVEVTPGSETS--YTLTGLKPGTEYEFRV 74

                         90       100
                 ....*....|....*....|...
gi 149065991 210 RVIAQRGktrtWSPWSQPMAFRT 232
Cdd:cd00063   75 RAVNGGG----ESPPSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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