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Conserved domains on  [gi|227085876|gb|EEI21188|]
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hypothetical protein HMPREF0497_0016, partial [Lentilactobacillus buchneri ATCC 11577]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 1-120 1.00e-73

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PRK07324:

Pssm-ID: 450240  Cd Length: 373  Bit Score: 223.28  E-value: 1.00e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876   1 MICCGVFNDAMAVYILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQAVSTSFPKLDIPEDIETFCIRLLKEQG 80
Cdd:PRK07324 252 MICAGVFDDMLASLALEHRDAILERNRKIVRTNLAILDEWVAKEPRVSYVKPKAVSTSFVKLDVDMPSEDFCLKLLKETG 331

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 227085876  81 VLLVPGTRFDMPGHVRLGYCADESTLREGLNRLSTFMRQY 120
Cdd:PRK07324 332 VLLVPGNRFDLEGHVRIGYCCDTETLKKGLKKLSEFLREF 371
 
Name Accession Description Interval E-value
PRK07324 PRK07324
transaminase; Validated
 1-120 1.00e-73

transaminase; Validated


Pssm-ID: 235989  Cd Length: 373  Bit Score: 223.28  E-value: 1.00e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876   1 MICCGVFNDAMAVYILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQAVSTSFPKLDIPEDIETFCIRLLKEQG 80
Cdd:PRK07324 252 MICAGVFDDMLASLALEHRDAILERNRKIVRTNLAILDEWVAKEPRVSYVKPKAVSTSFVKLDVDMPSEDFCLKLLKETG 331

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 227085876  81 VLLVPGTRFDMPGHVRLGYCADESTLREGLNRLSTFMRQY 120
Cdd:PRK07324 332 VLLVPGNRFDLEGHVRIGYCCDTETLKKGLKKLSEFLREF 371
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
 12-120 2.42e-16

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 73.24  E-value: 2.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876  12 AVYILKHRDQVLD-------RNRKLVLNNLKiykdwiasEPRASVVMPQA---VstsFPKLD-IPEDIETFCIRLLKEQG 80
Cdd:COG0436  277 AAAALEGPQDYVEemraeyrRRRDLLVEGLN--------EIGLSVVKPEGafyL---FADVPeLGLDSEEFAERLLEEAG 345

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 227085876  81 VLLVPGTRFDM--PGHVRLGYCADESTLREGLNRLSTFMRQY 120
Cdd:COG0436  346 VAVVPGSAFGPagEGYVRISYATSEERLEEALERLARFLERY 387
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 2-113 2.14e-15

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 70.45  E-value: 2.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876   2 ICCGVFNDAMAVYILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQAVSTSFPKLDIPEDiETFCIRLLKEQGV 81
Cdd:cd00609  236 SGPSTLSQAAAAAALDDGEEHLEELRERYRRRRDALLEALKELGPLVVVKPSGGFFLWLDLPEGDD-EEFLERLLLEAGV 314

                         90       100       110
                 ....*....|....*....|....*....|....
gi 227085876  82 LLVPGTRFDM--PGHVRLGYCADESTLREGLNRL 113
Cdd:cd00609  315 VVRPGSAFGEggEGFVRLSFATPEEELEEALERL 348
tyr_nico_aTase TIGR01265
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ...
 10-116 9.23e-11

tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.


Pssm-ID: 188123  Cd Length: 403  Bit Score: 57.35  E-value: 9.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876   10 AMAVYILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQAVSTSFPKL------DIPEDIEtFCIRLLKEQGVLL 83
Cdd:TIGR01265 287 ALPDILENTPQEFFDGKISVLKSNAELCYEELKDIPGLVCPKPEGAMYLMVKLelelfpEIKDDVD-FCEKLAREESVIC 365

                          90       100       110
                  ....*....|....*....|....*....|...
gi 227085876   84 VPGTRFDMPGHVRLGYCADESTLREGLNRLSTF 116
Cdd:TIGR01265 366 LPGSAFGLPNWVRITITVPESMLEEACSRIKEF 398
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
7-113 2.86e-05

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 41.52  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876    7 FNDAMAVYILKHRDQVLDRNRKLvlnnlkiykDWIASEPRASVVmpqavstSFPKLDiPEDIETFCIRLLKEQGVLLVPG 86
Cdd:pfam00155 261 ELEEMRQRIKERRDYLRDGLQAA---------GLSVLPSQAGFF-------LLTGLD-PETAKELAQVLLEEVGVYVTPG 323

                          90       100
                  ....*....|....*....|....*...
gi 227085876   87 TRFDMPGHVRLGYCA-DESTLREGLNRL 113
Cdd:pfam00155 324 SSPGVPGWLRITVAGgTEEELEELLEAI 351
 
Name Accession Description Interval E-value
PRK07324 PRK07324
transaminase; Validated
 1-120 1.00e-73

transaminase; Validated


Pssm-ID: 235989  Cd Length: 373  Bit Score: 223.28  E-value: 1.00e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876   1 MICCGVFNDAMAVYILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQAVSTSFPKLDIPEDIETFCIRLLKEQG 80
Cdd:PRK07324 252 MICAGVFDDMLASLALEHRDAILERNRKIVRTNLAILDEWVAKEPRVSYVKPKAVSTSFVKLDVDMPSEDFCLKLLKETG 331

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 227085876  81 VLLVPGTRFDMPGHVRLGYCADESTLREGLNRLSTFMRQY 120
Cdd:PRK07324 332 VLLVPGNRFDLEGHVRIGYCCDTETLKKGLKKLSEFLREF 371
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
 12-120 2.42e-16

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 73.24  E-value: 2.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876  12 AVYILKHRDQVLD-------RNRKLVLNNLKiykdwiasEPRASVVMPQA---VstsFPKLD-IPEDIETFCIRLLKEQG 80
Cdd:COG0436  277 AAAALEGPQDYVEemraeyrRRRDLLVEGLN--------EIGLSVVKPEGafyL---FADVPeLGLDSEEFAERLLEEAG 345

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 227085876  81 VLLVPGTRFDM--PGHVRLGYCADESTLREGLNRLSTFMRQY 120
Cdd:COG0436  346 VAVVPGSAFGPagEGYVRISYATSEERLEEALERLARFLERY 387
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 2-113 2.14e-15

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 70.45  E-value: 2.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876   2 ICCGVFNDAMAVYILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQAVSTSFPKLDIPEDiETFCIRLLKEQGV 81
Cdd:cd00609  236 SGPSTLSQAAAAAALDDGEEHLEELRERYRRRRDALLEALKELGPLVVVKPSGGFFLWLDLPEGDD-EEFLERLLLEAGV 314

                         90       100       110
                 ....*....|....*....|....*....|....
gi 227085876  82 LLVPGTRFDM--PGHVRLGYCADESTLREGLNRL 113
Cdd:cd00609  315 VVRPGSAFGEggEGFVRLSFATPEEELEEALERL 348
PRK05764 PRK05764
aspartate aminotransferase; Provisional
 67-120 1.17e-14

aspartate aminotransferase; Provisional


Pssm-ID: 235596  Cd Length: 393  Bit Score: 68.23  E-value: 1.17e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 227085876  67 DIETFCIRLLKEQGVLLVPGTRFDMPGHVRLGYCADESTLREGLNRLSTFMRQY 120
Cdd:PRK05764 339 DSLEFAEALLEEAGVAVVPGIAFGAPGYVRLSYATSLEDLEEGLERIERFLESL 392
PRK06836 PRK06836
pyridoxal phosphate-dependent aminotransferase;
24-120 3.71e-14

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180720  Cd Length: 394  Bit Score: 67.14  E-value: 3.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876  24 DRNRKLVLNNLKiykdwiasepRA--SVVMPQAVSTSFPKLDIPEDIEtFCiRLLKEQGVLLVPGTRFDMPGHVRLGYCA 101
Cdd:PRK06836 306 KRNRDLLYDGLT----------ELgfECVKPQGAFYLFPKSPEEDDVA-FC-EKAKKHNLLLVPGSGFGCPGYFRLSYCV 373

                         90
                 ....*....|....*....
gi 227085876 102 DESTLREGLNRLSTFMRQY 120
Cdd:PRK06836 374 DTETIERSLPAFEKLAKEY 392
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 27-120 2.00e-11

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 59.37  E-value: 2.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876  27 RKLVLNNLKiykdwiaSEPRASVVMPQAVSTSFPKLDIP----EDIETFCIRLLKEQGVLLVPGTRF--DMPGHVRLGYC 100
Cdd:PRK13355 423 RELVYNALN-------AIPGISAVKPKAAFYIFPKIDVKkfniHDDEQFALDLLHDKKVLIVQGTGFnwDKPDHFRVVYL 495

                         90       100
                 ....*....|....*....|
gi 227085876 101 ADESTLREGLNRLSTFMRQY 120
Cdd:PRK13355 496 PRLEDLEDAMDRLADFFSYY 515
tyr_nico_aTase TIGR01265
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ...
 10-116 9.23e-11

tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.


Pssm-ID: 188123  Cd Length: 403  Bit Score: 57.35  E-value: 9.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876   10 AMAVYILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQAVSTSFPKL------DIPEDIEtFCIRLLKEQGVLL 83
Cdd:TIGR01265 287 ALPDILENTPQEFFDGKISVLKSNAELCYEELKDIPGLVCPKPEGAMYLMVKLelelfpEIKDDVD-FCEKLAREESVIC 365

                          90       100       110
                  ....*....|....*....|....*....|...
gi 227085876   84 VPGTRFDMPGHVRLGYCADESTLREGLNRLSTF 116
Cdd:TIGR01265 366 LPGSAFGLPNWVRITITVPESMLEEACSRIKEF 398
PRK07683 PRK07683
aminotransferase A; Validated
 71-119 2.72e-10

aminotransferase A; Validated


Pssm-ID: 236075  Cd Length: 387  Bit Score: 55.89  E-value: 2.72e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 227085876  71 FCIRLLKEQGVLLVPGTRFDM--PGHVRLGYCADESTLREGLNRLSTFMRQ 119
Cdd:PRK07683 333 FALDLVEEAGLAVVPGSAFSEygEGYVRLSYAYSIETLKEGLDRLEAFLQQ 383
PRK06108 PRK06108
pyridoxal phosphate-dependent aminotransferase;
3-119 8.85e-09

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180404  Cd Length: 382  Bit Score: 51.48  E-value: 8.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876   3 CCGVFNDAMAVYILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQAVSTSFPKLDIPEDIETFCIRLLKEQGVL 82
Cdd:PRK06108 264 CVAQFVQRAAVAALDEGEDFVAELVARLRRSRDHLVDALRALPGVEVAKPDGAMYAFFRIPGVTDSLALAKRLVDEAGLG 343

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 227085876  83 LVPGTRF--DMPGHVRLGYCADESTLREGLNRLSTFMRQ 119
Cdd:PRK06108 344 LAPGTAFgpGGEGFLRWCFARDPARLDEAVERLRRFLAR 382
PRK07309 PRK07309
pyridoxal phosphate-dependent aminotransferase;
7-120 1.05e-08

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235985  Cd Length: 391  Bit Score: 51.65  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876   7 FNDA--MAVYILKHRDQVLDRNRKLvlnNLKIYKdwiaseprasvvmPQAVSTSFPKL--DIPEDIETFCIRLLKEQGVL 82
Cdd:PRK07309 286 KDDAlpMKKEYIKRRDYIIEKMTDL---GFKIIK-------------PDGAFYIFAKIpaGYNQDSFKFLQDFARKKAVA 349

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 227085876  83 LVPGTRFDM--PGHVRLGYCADESTLREGLNRLSTFMRQY 120
Cdd:PRK07309 350 FIPGAAFGPygEGYVRLSYAASMETIKEAMKRLKEYMEEH 389
PLN02656 PLN02656
tyrosine transaminase
 7-116 2.06e-08

tyrosine transaminase


Pssm-ID: 178262 [Multi-domain]  Cd Length: 409  Bit Score: 50.69  E-value: 2.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876   7 FNDAMAVYILKHRDQVLdrnRKLVLNNLK----IYKDWIAS--------EPRASVVMPQAVSTSFPKlDIPEDIEtFCIR 74
Cdd:PLN02656 284 FIQAAVPTILEQTDESF---FKKTINILKqssdICCDRIKEipcitcphKPEGSMAVMVKLNLSLLE-DISDDID-FCFK 358

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 227085876  75 LLKEQGVLLVPGTRFDMPGHVRLGYCADESTLREGLNRLSTF 116
Cdd:PLN02656 359 LAREESVIILPGTAVGLKNWLRITFAADPSSLEEALGRIKSF 400
PLN00145 PLN00145
tyrosine/nicotianamine aminotransferase; Provisional
 63-120 7.41e-08

tyrosine/nicotianamine aminotransferase; Provisional


Pssm-ID: 215074 [Multi-domain]  Cd Length: 430  Bit Score: 49.00  E-value: 7.41e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 227085876  63 DIPEDIEtFCIRLLKEQGVLLVPGTRFDMPGHVRLGYCADESTLREGLNRLSTFMRQY 120
Cdd:PLN00145 369 GIKDDMD-FCCKLAKEESVVVLPGSALGMKNWLRITFAIDPPSLEDGLERLKSFCLRH 425
PRK08363 PRK08363
alanine aminotransferase; Validated
 45-119 1.53e-07

alanine aminotransferase; Validated


Pssm-ID: 181402  Cd Length: 398  Bit Score: 48.27  E-value: 1.53e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 227085876  45 PRASVVMPQAVSTSFPKLDIPEDI--ETFCIRLLKEQGVLLVPGTRFDMPG--HVRLGYCADESTLREGLNRLSTFMRQ 119
Cdd:PRK08363 316 PGISTTKPQGAFYIFPRIEEGPWKddKEFVLDVLHEAHVLFVHGSGFGEYGagHFRLVFLPPVEILEEAMDRFEEFMRE 394
PLN00143 PLN00143
tyrosine/nicotianamine aminotransferase; Provisional
 63-120 2.43e-07

tyrosine/nicotianamine aminotransferase; Provisional


Pssm-ID: 165711 [Multi-domain]  Cd Length: 409  Bit Score: 47.70  E-value: 2.43e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 227085876  63 DIPEDIEtFCIRLLKEQGVLLVPGTRFDMPGHVRLGYCADESTLREGLNRLSTFMRQY 120
Cdd:PLN00143 349 DIEDDME-FCLKLAKEESLIILPGVTVGLKNWLRITFAVEQSSLEDGLGRLKSFCGRH 405
PRK08912 PRK08912
aminotransferase;
49-118 7.07e-07

aminotransferase;


Pssm-ID: 181580  Cd Length: 387  Bit Score: 46.12  E-value: 7.07e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 227085876  49 VVMPQA----VSTSFPKLDIPEDIETFCIRLLKEQGVLLVPGTRF----DMPGHVRLGYCADESTLREGLNRLSTFMR 118
Cdd:PRK08912 308 PVLPSQgtyfLTVDLAPLGLAEDDVAFCRRLVEEAGVAAIPVSAFyeedPVTSVVRFCFAKRDATLDEAVERLAAARR 385
PRK06348 PRK06348
pyridoxal phosphate-dependent aminotransferase;
12-113 9.78e-07

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180537  Cd Length: 384  Bit Score: 45.87  E-value: 9.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876  12 AVYILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQAVSTSFPKL-DIPEDIETFCIRLLKEQGVLLVPGTRFD 90
Cdd:PRK06348 275 AIYALKHRDTIVPLIKEEFQKRLEYAYKRIESIPNLSLHPPKGSIYAFINIkKTGLSSVEFCEKLLKEAHVLVIPGKAFG 354

                         90       100
                 ....*....|....*....|....*
gi 227085876  91 MPG--HVRLGYCADESTLREGLNRL 113
Cdd:PRK06348 355 ESGegYIRLACTVGIEVLEEAFNRI 379
PTZ00433 PTZ00433
tyrosine aminotransferase; Provisional
 4-116 1.07e-06

tyrosine aminotransferase; Provisional


Pssm-ID: 185613  Cd Length: 412  Bit Score: 45.93  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876   4 CGVFNDAMAVYILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQA-----VSTSFPKL-DIPEDIEtFCIRLLK 77
Cdd:PTZ00433 288 CSVVQAALGEALLNTPQEHLEQIVAKLEEGAMVLYNHIGECIGLSPTMPRGsmflmSRLDLEKFrDIKSDVE-FYEKLLE 366

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 227085876  78 EQGVLLVPGTRFDMPGHVRLGYCADESTLREGLNRLSTF 116
Cdd:PTZ00433 367 EENVQVLPGEIFHMPGFTRLTISRPVEVLREAVERIKAF 405
tyr_amTase_E TIGR01264
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found ...
 4-120 2.05e-06

tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found in animals and Trypanosoma cruzi. It is the first enzyme of a pathway of tyrosine degradation via homogentisate. Several plant enzyme designated as probable tyrosine aminotransferases are very closely related to an experimentally demonstrated nicotianamine aminotransferase, an enzyme in a siderophore (iron uptake chelator) biosynthesis pathway. These plant sequences are excluded from the model seed and score between the trusted an noise cutoffs. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273529 [Multi-domain]  Cd Length: 401  Bit Score: 44.77  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876    4 CGVFNDAMAVYILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQAVS--------TSFPklDIPEDIEtFCIRL 75
Cdd:TIGR01264 279 CTIVQGALPSILLRTPQEYFDGTLSVLESNAMLCYGALAAVPGLRPVMPSGAMymmvgiemEHFP--EFKNDVE-FTERL 355

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 227085876   76 LKEQGVLLVPGTRFDMPGHVRLGYCADESTLREGLNRLSTFMRQY 120
Cdd:TIGR01264 356 VAEQSVFCLPGSCFEYPGFFRVVLTVPVVMMEEACSRIQEFCERH 400
PRK08361 PRK08361
aspartate aminotransferase; Provisional
 21-113 1.67e-05

aspartate aminotransferase; Provisional


Pssm-ID: 236248 [Multi-domain]  Cd Length: 391  Bit Score: 42.17  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876  21 QVLDRNRKLVLNNLKiykdwiaSEPRASVVMPQAVSTSFPKLDIPE-DIETFCIRLLKEQGVLLVPGTRFDM--PGHVRL 97
Cdd:PRK08361 296 KEYNERRKLVLKRLK-------EMPHIKVFEPKGAFYVFANIDETGmSSEDFAEWLLEKARVVVIPGTAFGKagEGYIRI 368

                         90
                 ....*....|....*.
gi 227085876  98 GYCADESTLREGLNRL 113
Cdd:PRK08361 369 SYATSKEKLIEAMERM 384
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
7-113 2.86e-05

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 41.52  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876    7 FNDAMAVYILKHRDQVLDRNRKLvlnnlkiykDWIASEPRASVVmpqavstSFPKLDiPEDIETFCIRLLKEQGVLLVPG 86
Cdd:pfam00155 261 ELEEMRQRIKERRDYLRDGLQAA---------GLSVLPSQAGFF-------LLTGLD-PETAKELAQVLLEEVGVYVTPG 323

                          90       100
                  ....*....|....*....|....*...
gi 227085876   87 TRFDMPGHVRLGYCA-DESTLREGLNRL 113
Cdd:pfam00155 324 SSPGVPGWLRITVAGgTEEELEELLEAI 351
PLN00175 PLN00175
aminotransferase family protein; Provisional
 67-119 5.41e-05

aminotransferase family protein; Provisional


Pssm-ID: 215089 [Multi-domain]  Cd Length: 413  Bit Score: 41.00  E-value: 5.41e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 227085876  67 DIEtFCIRLLKEQGVLLVPGTRF-----DMPGHVRLGYCADESTLREGLNRLSTFMRQ 119
Cdd:PLN00175 357 DIA-FCEYLIEEVGVAAIPPSVFylnpeDGKNLVRFAFCKDEETLRAAVERMKTKLKR 413
avtA PRK09440
valine--pyruvate transaminase; Provisional
 76-119 5.49e-05

valine--pyruvate transaminase; Provisional


Pssm-ID: 236517  Cd Length: 416  Bit Score: 40.99  E-value: 5.49e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 227085876  76 LKEQGVLLVPGTRFdMPG------H----VRLGYCADESTLREGLNRLSTFMRQ 119
Cdd:PRK09440 359 LKARGVLVVPGHYF-FPGldedwpHahqcIRMNYVQDDEEIEKGIAILAEEVEK 411
PRK08960 PRK08960
pyridoxal phosphate-dependent aminotransferase;
15-118 6.22e-04

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 181595  Cd Length: 387  Bit Score: 37.73  E-value: 6.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876  15 ILKHRDQVLDRNRKLVLNNLKIYKDWIASEPRASVVMPQAVSTsfpkldIPEDIETFCIRLLKEQGVLLVPGTRF--DMP 92
Cdd:PRK08960 286 ILEARRAEFARRRDFLLPALRELGFGIAVEPQGAFYLYADISA------FGGDAFAFCRHFLETEHVAFTPGLDFgrHQA 359

                         90       100
                 ....*....|....*....|....*..
gi 227085876  93 G-HVRLGYCADESTLREGLNRLSTFMR 118
Cdd:PRK08960 360 GqHVRFAYTQSLPRLQEAVERIARGLR 386
PRK07366 PRK07366
LL-diaminopimelate aminotransferase;
48-117 7.01e-04

LL-diaminopimelate aminotransferase;


Pssm-ID: 180947  Cd Length: 388  Bit Score: 37.74  E-value: 7.01e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 227085876  48 SVVMPQAVSTSFPKLdiPEDIET----FCIRLLKEQGVLLVPGTRFDM--PGHVRLGYCADESTLREGLNRLSTFM 117
Cdd:PRK07366 315 PVPLPEATMYVWAKL--PEPWQGnsveFCTQLVAQTGVAASPGSGFGKsgEGYVRFALVHDPDILEEAVERIAAFL 388
PTZ00377 PTZ00377
alanine aminotransferase; Provisional
 59-120 1.26e-03

alanine aminotransferase; Provisional


Pssm-ID: 240391 [Multi-domain]  Cd Length: 481  Bit Score: 36.87  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227085876  59 FPKLDIPE-------------DiETFCIRLLKEQGVLLVPGTRFDM-PG--HVRLGYCADESTLREGLNRLSTF----MR 118
Cdd:PTZ00377 400 FPRIELPEkaiqeakerglapD-VLYCLELLESTGIVVVPGSGFGQkPGtyHFRITILPPEEQIEEMVKKIKEFhesfMK 478


                 ..
gi 227085876 119 QY 120
Cdd:PTZ00377 479 KY 480
PRK07682 PRK07682
aminotransferase;
69-119 1.38e-03

aminotransferase;


Pssm-ID: 181082 [Multi-domain]  Cd Length: 378  Bit Score: 36.64  E-value: 1.38e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 227085876  69 ETFCIRLLKEQGVLLVPGTRFDMP--GHVRLGYCADESTLREGLNRLSTFMRQ 119
Cdd:PRK07682 324 EEFAEQLLLEEKVAVVPGSVFGESgeGFIRCSYATSLEQLQEAMKRMKRFVEN 376
PRK07550 PRK07550
aminotransferase;
74-116 1.58e-03

aminotransferase;


Pssm-ID: 181026 [Multi-domain]  Cd Length: 386  Bit Score: 36.47  E-value: 1.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 227085876  74 RLLKEQGVLLVPGTRFdMPG---HVRLGYC-ADESTLREGLNRLSTF 116
Cdd:PRK07550 339 RLAKEAGILCLPGTMF-GPGqegYLRLAFAnADVAGIGELVERLRAF 384
PRK08068 PRK08068
transaminase; Reviewed
 62-114 5.46e-03

transaminase; Reviewed


Pssm-ID: 181219  Cd Length: 389  Bit Score: 34.90  E-value: 5.46e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 227085876  62 LDIPEDI--ETFCIRLLKEQGVLLVPGTRFDM--PGHVRLGYCADESTLREGLNRLS 114
Cdd:PRK08068 328 MPVPKGYtsEQFADLLLEKAHVAVAPGNGFGEhgEGYVRVGLLTDEERLREAVERIG 384
PRK12414 PRK12414
putative aminotransferase; Provisional
 71-116 8.65e-03

putative aminotransferase; Provisional


Pssm-ID: 183514  Cd Length: 384  Bit Score: 34.38  E-value: 8.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 227085876  71 FCIRLLKEQGVLLVPGTRFDMPGH----VRLGYCADESTLREGLNRLSTF 116
Cdd:PRK12414 335 FVLRLIRDARVATIPLSAFYTDGTdtglIRLSFSKDDATLVEGARRLCSL 384
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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