BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321477399  46 DVFLLAFDdnlesrrISLSAHQEILAAASPYLAELLG-TSNDCDIYLSFSDFKQSELELLLDYIYTGEIHASRGLMEEFE 124
Cdd:cd18315    3 DVTLACEG-------GSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLL 75

                         90
                 ....*....|
gi 321477399 125 LCLKELGILG 134
Cdd:cd18315   76 KLAELLQIKG 85

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321477399 361 GKKPFDCTVCGC--AFRQKWSLKEHMLT-HDQPEENPFTCEVCNKSFQTR-RPFiahryshnkqtkRCPVCKKRFYNAER 436
Cdd:COG5189  346 DGKPYKCPVEGCnkKYKNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAKdKPY------------RCEVCDKRYKNLNG 413

                 ....*.
gi 321477399 437 LAQHMK 442
Cdd:COG5189  414 LKYHRK 419

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321477399  46 DVFLLAFDdnlesrrISLSAHQEILAAASPYLAELLG-TSNDCDIYLSFSDFKQSELELLLDYIYTGEIHASRGLMEEFE 124
Cdd:cd18315    3 DVTLACEG-------GSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLL 75

                         90
                 ....*....|
gi 321477399 125 LCLKELGILG 134
Cdd:cd18315   76 KLAELLQIKG 85

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321477399 211 DDRPYVCPV--CQKSFRHLNVLRTHsRVHTGEKPFTcstcnrsfsHKSTLSEHMNLHS-DDRPYECSKCQRRFKQRKGLR 287
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKL---------HENPSPEKMNIFSaKDKPYRCEVCDKRYKNLNGLK 415

                 ....*.
gi 321477399 288 AHRCEY 293
Cdd:COG5189  416 YHRKHS 421

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321477399 361 GKKPFDCTVCGC--AFRQKWSLKEHMLT-HDQPEENPFTCEVCNKSFQTR-RPFiahryshnkqtkRCPVCKKRFYNAER 436
Cdd:COG5189  346 DGKPYKCPVEGCnkKYKNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAKdKPY------------RCEVCDKRYKNLNG 413

                 ....*.
gi 321477399 437 LAQHMK 442
Cdd:COG5189  414 LKYHRK 419

hypothetical protein

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 321477399 393 NPFTCEVCNKSFQTRRPFIAH-RYShnKQTKRCPVCKKRFYNAERLAQHM-KDH 444
Cdd:PHA00733  72 SPYVCPLCLMPFSSSVSLKQHiRYT--EHSKVCPVCGKEFRNTDSTLDHVcKKH 123

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321477399  46 DVFLLAFDdnlesrrISLSAHQEILAAASPYLAELLG-TSNDCDIYLSFSDFKQSELELLLDYIYTGEIHASRGLMEEFE 124
Cdd:cd18315    3 DVTLACEG-------GSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLL 75

                         90
                 ....*....|
gi 321477399 125 LCLKELGILG 134
Cdd:cd18315   76 KLAELLQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321477399    46 DVFLlafddNLESRRISlsAHQEILAAASPYLAELLGT----SNDCDIYLSFSDFKqsELELLLDYIYTGEIHASRGLME 121
Cdd:smart00225   1 DVTL-----VVGGKKFH--AHKAVLAAHSPYFKALFSSdfkeSDKSEIYLDDVSPE--DFRALLNFLYTGKLDLPEENVE 71

                           90       100
                   ....*....|....*....|....*
gi 321477399   122 EFelcLKELGILGTHSLV--CTEEI 144
Cdd:smart00225  72 EL---LELADYLQIPGLVelCEEFL 93

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 321477399   39 RKSQFKPDVFLLAfddnlESRRISlsAHQEILAAASPYLAELLgTSNDCDIYLS---FSDFKQSELELLLDYIYTGEI 113
Cdd:pfam00651   5 REQGELCDVTLVV-----GDKEFR--AHKAVLAACSPYFKALF-SGQESESSVSeitLDDVSPEDFEALLEFMYTGKL 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 321477399  62 SLSAHQEILAAASPYLAELLGTSNDCDIYL--SFSDFkqseLELLLDYIYTGEIHASRGLMEEFELCLKELGIL 133
Cdd:cd18232   29 VFKAHWSVLACCSHFFQSLYGDGTSGSVVLpeSFAEV----FGLLLDFFYTGELALTRENRDRVLLAAKELRVP 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321477399  37 HARKSQFKPDVFLLAfdDNLEsrrisLSAHQEILAAASPYLAEL----LGTSNDCDIYLSFSDFKQseLELLLDYIYTGE 112
Cdd:cd18235   14 ELRKQNLLCDVILVA--DGVE-----IPAHRVVLASCSPYFHAMftgdLSESRANRVTLQDVDGKA--LLLLIDYVYTAE 84

                 .
gi 321477399 113 I 113
Cdd:cd18235   85 I 85

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321477399 214 PYVCPVCQKSFRHLNVLRTHSR--VHTGE--KPFTC--STCNRSFSHKSTLSEHMNLHSDDRPYECSKCQRRFKQRKGLR 287
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321477399 288 AHRCEYLlkAHQMTHNEEKRYECDV--CHKKFALKKTLQVHETSHKTDKGP-YKCSYCPKSFRYVANLNTHELIHSGKKP 364
Cdd:COG5048  369 NEPPQSL--QQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYnCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                 ...
gi 321477399 365 FDC 367
Cdd:COG5048  447 LLC 449

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 321477399  65 AHQEILAAASPYLAELLGTS---NDCDIY------LSFSDFKQselelLLDYIYTGEI 113
Cdd:cd18245   28 VQKNVLAAASPYFRAKLNYNppkDDGSTYkielegISVEVMEE-----ILDYIYTGQI 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 321477399  65 AHQEILAAASPYLAELLGTSNDCDIYLSFSDFKQSELELLLDYIYTGEIHASRGLMEEFELCLKELGI 132
Cdd:cd18217   32 AHRNVLAAFSEYFGAQYKDTEDNIVFLDQSQVSADGFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGM 99

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*
gi 321477399  230 LRTHSRVHTGEKPFTCSTCNRSFSH 254
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 321477399  60 RISLSAHQEILAAASPYLAELLGTSndCDIYLSfSDFKQSELELLLDYIYTGEIhasrglmEEFELCLKEL 130
Cdd:cd18299   22 GVRIFAHRIVLAAASSVFADLFLMM--TVVTLD-SDITPEAFRRVLEFLYTGVL-------DENEDDLKEL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 321477399  62 SLSAHQEILAAASPYL-AELLGTSNDCDIylsfSDFKQSELELLLDYIYTGEI 113
Cdd:cd18303   29 SIPAHKFVLAARSEKWsNENLASTNELDL----SDISYEVVLALLRWLYTDEL 77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321477399  39 RKSQFKPDVFLLAFDdnlesrrISLSAHQEILAAASPYLAELLgTSNDCD---IYLSFSDFKQSELELLLDYIYTGEIHA 115
Cdd:cd18339   16 RSKQLLCDVTIVAED-------VEIEAHRVVLAACSPYFCAMF-TGDMSEskaKKIEIKDVDGQTLSKLIDYIYTAEIEV 87

                 .
gi 321477399 116 S 116
Cdd:cd18339   88 T 88