|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-384 |
2.91e-36 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 135.78 E-value: 2.91e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 22 LFLMEFARGMYILSYINFLPTVTS---IAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLVIW 98
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAEslgASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 99 FPaSPFIIIFSAIMLGIAVSPIWVIMLS----SVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKF--HPTRFAFLMAL 172
Cdd:cd17325 81 AT-SYWQLLLARFLQGLASAAVWPAAMAliadIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAlgYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 173 VVLIAWVLYYFVNINLTNYNTKPVKAQLKQ----IVDVTQRHLILFPGILLQGAAIAALVPILPKYATQVVKVSTVGYTV 248
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRsglrLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 249 AIIIGGIGCAFSMLFLSKIIDNNSKgfmYGVIFSGFILYTILIFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGH 328
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGR---KPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 394268256 329 INPNEQEETWGVFNSVQGFGSMIGPLVGGLITQfTNNLNNTFYFSAMIFLALAVFY 384
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLF 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-353 |
5.49e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.95 E-value: 5.49e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 18 MLVILFLMEFARGMYILSYINFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLVI 97
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 98 WFPASPFIIIFSAIMlGIAVSPIWVIMLSSV----DERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFLMALV 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQ-GLGAGALFPAALALIadwfPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 174 VLIAWVLYYFVNINLTNYNTKPVKAQLKQIVDV------TQRHLILFPGILLQGAAIAALVPILPKYAtQVVKVSTVGYT 247
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVawkallRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 248 VAIIIGGIGCAFSMLFLSKIIDNNSKGFMYGVIFSGFILYTILIFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAG 327
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....*.
gi 394268256 328 HINPNEQEETWGVFNSVQGFGSMIGP 353
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-349 |
7.34e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 78.09 E-value: 7.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 17 MMLVILFLMEFARGMYILSYINFLPTVTS---IAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISL 93
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAAdlgASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 94 FLVIWFPaSPFIIIFSAIMLGIAVSPIWVIMLS----SVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFL 169
Cdd:COG2814 90 LLCALAP-SLWLLLAARFLQGLGAGALFPAALAliadLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 170 -MALVVLIAWVLYYFVNINLTNYNTKPVKAQLKQIVdVTQRHLILFPGILLQGAAIAALVPILPKYATQVVKVSTVGYTV 248
Cdd:COG2814 169 vNAVLALLALLLLLRLLPESRPAARARLRGSLRELL-RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 249 AIIIGGIGCAFSMLFLSKIIDnnsKGFMYGVIFSGFILYTILIFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGH 328
Cdd:COG2814 248 LLALFGLGGVLGALLAGRLAD---RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330 340
....*....|....*....|.
gi 394268256 329 INPNEQEETWGVFNSVQGFGS 349
Cdd:COG2814 325 APPEARGRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-384 |
4.97e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 66.68 E-value: 4.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 19 LVILFLMEFARGMYILSYINFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLvIW 98
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL-FA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 99 FPASPFIIIFSAIMLGIAVSPIWVIMLS----SVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFA---FLMA 171
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLAliadLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRavfLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 172 LVVLIAWVLYYFVNINLTNYNTKPVKAQLKQIVDVTQRHLILFPG-------ILLQGAAIAALVPILPKYATQVVKVSTV 244
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGlwllllaIFLVNLAYYSFSTLLPLFLLDLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 245 GYTVAIIIGGIGCAFSMLFLSKIIDNNSKGFmyGVIFSGFILYTILIFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTF 324
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRK--PLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 325 MAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTNNLNNTFYFSAMIFLALAVFY 384
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
52-393 |
9.06e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 65.66 E-value: 9.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 52 SFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLVIWFPaSPFIIIFSAIMLGIAVSPIWVIMLSSV--- 128
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT-SFWQLLLLRFLLGLGEAGFFPAALKLIaew 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 129 -DERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFLMALVVLIAWVLYYFvninltnyntkpvkaqlkqivdvt 207
Cdd:COG2271 127 fPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF------------------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 208 qrhLILFPGILLQGAAIAALVPILPKYATQVVKVSTVGYTVAIIIGGIGCAFSMLFLSKIIDNNSKGFMYgVIFSGFILY 287
Cdd:COG2271 183 ---WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL-VLAIGLLLA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 288 TILIFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTnNLN 367
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQ 337
|
330 340
....*....|....*....|....*.
gi 394268256 368 NTFYFSAMIFLALAVFYGYYFIKTNR 393
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLRETRK 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-394 |
2.87e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.41 E-value: 2.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 15 FVMMLVILFLMEFARGMyILSYINFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLF 94
Cdd:COG0738 10 LIAIYLLFFLWGFATAL-WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 95 LVIWFPaSPFIIIFSAIMLGIAVSPIWVIM---LSSVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFA---- 167
Cdd:COG0738 89 LFALAP-SYPLLLLALFLLGLGLGLLDVAAnpyVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWhlpy 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 168 FLMALVVLIAWVLYYFVNINLTNYNTKPVKAQLKQIVDVTQRHLILFpGILLQGAAIAALVPI---LPKYATQVVKVSTV 244
Cdd:COG0738 168 LILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLL-GGLAIFLYVGAEGAIgdwLPLYLKDVLGLSEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 245 GYTVAIIIGGIGCAFSMLFLSKIIDN-NSKGFMYGVIFSGFILYTILIFGLSTITNIYIVWAIGLFIGLMYGILLPAwnt 323
Cdd:COG0738 247 TAALGLSLFWGGMTIGRFLGGFLLKRfGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSL--- 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 394268256 324 fmAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTnNLNNTFYFSAmIFLALAVFYGYYFIKTNRR 394
Cdd:COG0738 324 --ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLVPL-VCYLLILLLALALKRKRRK 390
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
18-387 |
1.02e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 59.55 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 18 MLVILFLMEFARGMYILSYINFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISlFLVI 97
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG-FALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 98 WFPASPFIIIFSAIMLGIAVS----PIWVIMLSSVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPtRFAFLMALV 173
Cdd:cd17329 83 GFAHSPWLFAIALVLTGFGGGlfepASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-RLLFLAAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 174 VLI--AWVLYYFVNINLTNYNTKPVKAQLKQIVDVTQRH--LILFPGILLQGAAIAALVPILPKYATQVVKVSTVGYTVA 249
Cdd:cd17329 162 LFLlaALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRafLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 250 IIIGGIGCAFSMLFLSKIIDNNSKGFmygVIFSGFILYTILIFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGHI 329
Cdd:cd17329 242 LALNALLIVLLQFPVARLVERFRLRK---ILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 394268256 330 NPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTNNLNNTFYFSAMIFLALAVFYGYY 387
Cdd:cd17329 319 PPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-388 |
1.03e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.53 E-value: 1.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 53 FAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLVIwFPASPFIIIFSAIMLGIAVSPIWV----IMLSSV 128
Cdd:cd17489 35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL-LATSVALLLVLRLIHGIGWGAFTTaaatLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 129 DERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFLMALVV-LIAWVLYYFVninltnYNTKPVKAQLKQIVDVT 207
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLaLLALLLVFLV------KDPPPVAAEEAEAGTRA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 208 QRHL----ILFPGILLQGAAIA--ALVPILPKYATQVvkvSTVGYTVAIIIGGIGCAFSMLFLSKIIDnnsKGFMYGVIF 281
Cdd:cd17489 188 FRRLvekkVLPPALILFLASIAygAISTFLPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSD---RKGPKTVII 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 282 SGFILYTILIFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQ 361
Cdd:cd17489 262 PGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE 341
|
330 340
....*....|....*....|....*..
gi 394268256 362 FTnNLNNTFYFSAMIFLALAVFYGYYF 388
Cdd:cd17489 342 LF-GYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
79-388 |
1.10e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 59.54 E-value: 1.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 79 KLVLTSGFLLAFISLFLVIWFPaSPFIIIFSAIMLGIAVS---PIWVIMLSSVDERNRGKQMGYVYFSWLLGLLVGMVIM 155
Cdd:cd17490 62 KLFIIIGLLFTVLASLIMILFP-SPWGLLIARFLSGIAAAtwvSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 156 NLLIKFHPTRFAFLMALVV-LIAWVLYYFvnINLTNYNTKPVKAQLKQIVDVTQRHLILFP---GILLQGAAIAALVPIL 231
Cdd:cd17490 141 GLIAEHFGMRAPFLLAALAgVLGFILSLF--IKEERREKKPVLTELKELLSVLKDKKLLFFsllAILQQMITFSTTFGFT 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 232 PKYATQVVKVS---TVGYTVAIIIGGIGCAFSMLFLSKiidnnsKGFMYGVIFSGFILYTILIFGLSTITNIYIVWAIGL 308
Cdd:cd17490 219 PLIAKQLGASSfqlGLLSIIYLLPNALASLLSGTLFYK------KLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQA 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 309 FIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTnNLNNTFYFSAMIFLALAVFYGYYF 388
Cdd:cd17490 293 LNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAF-GLQTGFFVIGVIALLAAILSLAYY 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
51-383 |
2.67e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 58.35 E-value: 2.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 51 TSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLvIWFPASPFIIIFSAIMLGIAVSPIWVIMLSSV-- 128
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL-LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVsk 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 129 --DERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFL-MALVVLIAWVLYYFVNINLTNYNTKPVKAQLKQIVD 205
Cdd:COG2223 121 wfPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLiLGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 206 V--TQRHLILFPGILLQGAAIAALVPILPKYATQVVKVSTVGYTVAIIIGGIGCAFSMLFLSKIIDNNSKGFMYGVIFSG 283
Cdd:COG2223 201 AlrDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFAL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 284 FILYTILIFGLSTitNIYIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFT 363
Cdd:COG2223 281 MALGLLLLALALG--SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT 358
|
330 340
....*....|....*....|
gi 394268256 364 NNLNNTFYFSAMIFLALAVF 383
Cdd:COG2223 359 GSYTAAFLVFAVLALVALVL 378
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-359 |
5.75e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.60 E-value: 5.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 23 FLMEFARGMYILSYINFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSK--------LVLTSGFLLAFISLF 94
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrpwiLIGAIPLALSFVLLF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 95 LVIWFPASPFIIIFSA--IMLGIAVSPIWV-------IMLSSVDERNR--GKQMGYVYFSWLLGLLVGMVIMNLLIKFHP 163
Cdd:COG2211 100 TAPDLSPTGKLIYALVtyLLLGLAYTLVNIpysalgaELTPDYEERTRlsSWRFAFAGLGGLLASVLPPPLVAAFGGDAA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 164 TRFAFLMALVVLIAWVLYYFVNINLT-NYNTKPVKAQLKQIVDVTQRH---LILFPGILLQGAAIAALVPILPKYATQVV 239
Cdd:COG2211 180 LGYRLTALIFAVLGLLAFLLTFFGTKeRPVPEEEKVSLKESLKALLKNrpfLLLLLAYLLFFLALALVAALLLYYFKYVL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 240 KVSTVGYTVAIIIGGIGCAFSMLFLSKIIDNNSKGFMYGVIFSGFILYTILIFgLSTITNIYIVWAIGLFIGLMYGILLP 319
Cdd:COG2211 260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF-FLGPGNLWLLLVLAALAGIGLGAILV 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 394268256 320 AWNTFMAGHINPNEQEE-------TWGVFNSVQGFGSMIGPLVGGLI 359
Cdd:COG2211 339 LPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
55-386 |
1.01e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.43 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 55 FSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLVIWFPASPFIIIFSAImLGIAVSPIWVIMLSSV----DE 130
Cdd:cd17473 41 LTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRAL-LGIGVAGIMTLATALIgdyfEG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 131 RNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHpTRFAFLMALVVLIAWVLYYFVNINLTNYNTKPVKAQLKQIVDVTQRH 210
Cdd:cd17473 120 EERAKMLGLQSAAMSLGGVVFLLLGGALAEIG-WRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 211 LILFPGILLQGAAIAALVPI-LPKYATQVVKVSTVGYTVAIIIGGIGCAFSMLFLSKIIDNNSKGFMYGVifsGFILYTI 289
Cdd:cd17473 199 VLPIYFLAFLAMLLFYVIPIqLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI---GFALMAL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 290 LIFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTNNLNNT 369
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGA 355
|
330
....*....|....*..
gi 394268256 370 FYFSAMIFLALAVFYGY 386
Cdd:cd17473 356 FLILGVLALVLAIVLLL 372
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
56-383 |
7.05e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.72 E-value: 7.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 56 SIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLVIWFPASPFIIIFSAIMlGIAVSPIWVI----MLSSVDER 131
Cdd:cd17477 38 SAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVM-GIGLAGLFVVseswLNALATNE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 132 NRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAfLMALVVLIAWVLYYFVNINLTNYnTKPVKAQLKQIVdvtQRHL 211
Cdd:cd17477 117 NRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFL-IAAVLLLLALVPLLLTRRAAPEI-EEAESISLRRLL---RIAP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 212 ILFPGILLQGAAIAALVPILPKYATQV-VKVSTVGYTVAIIIggIGCAFSMLFLSKIIDNNSKGFMYgvIFSGFILYTIL 290
Cdd:cd17477 192 LALLGAFVAGFLEGAFYSLLPLYGLRLgLSVAQAALLLAAFV--LGGLLLQWPLGWLADRFDRRRVL--LGCALLGALAA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 291 IFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTNNlNNTF 370
Cdd:cd17477 268 LLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGP-HGLF 346
|
330
....*....|...
gi 394268256 371 YFSAMIFLALAVF 383
Cdd:cd17477 347 LFLAAVALLFLLF 359
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
45-383 |
7.72e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.71 E-value: 7.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 45 SIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLVIWFPASPFIIIFSAIM---LGIAVSPIW 121
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAglaHGGFWAIAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 122 VIMLSSVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFLM--ALVVLIAWVLYYFVNINLTNYNTKPVKAQ 199
Cdd:cd17324 110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAiaVLALLAALLLWRLLPSLPPKKPGSLGLLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 200 LKQIVDVTQRHLILFPGILLQGAAIAALVPILPKYATQVVKVSTVGYTVAIIIGGIGCAFSMLFLSKIIDNNSKGFmygv 279
Cdd:cd17324 190 SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA---- 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 280 IFSGFILYTILIFGLSTITNIYIVWAIGLFI-GLMYGILLPAWNTFmAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGL 358
Cdd:cd17324 266 LLIALLLLAAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYNLGGALGAALGGL 344
|
330 340
....*....|....*....|....*
gi 394268256 359 ITQFTNNLNNTFYFSAMIFLALAVF 383
Cdd:cd17324 345 VLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
18-384 |
2.00e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.58 E-value: 2.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 18 MLVILFLMEFARGMyILSYINFL---PTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLF 94
Cdd:cd17330 1 LFLVVFLDALGFGI-VFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 95 LVIWFPASPFIIIFSAI--MLGIAVSPIWVIMLSSVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFLMAL 172
Cdd:cd17330 80 LLGLSRNLWLLFLARFLdgLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 173 VVLIAWVLYYFVninltnyntkpvkaqlkqIVDVTQRHLILFpgiLLQGAAIAALVPILPKYATQVVKVSTVGYTVAIII 252
Cdd:cd17330 160 ALALLNLVLVLF------------------FLPPLRRLLLVY---FLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLAL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 253 GGIGCAFSMLFLSKIIdnNSKGFMYGVIFSGFILYTILIFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGHINPN 332
Cdd:cd17330 219 VGIAGILAQLLLIPRL--AKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSK 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 394268256 333 EQEETWGVFNSVQGFGSMIGPLVGGLITQFTNNLnnTFYFSAMIFLALAVFY 384
Cdd:cd17330 297 EQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPG--VPFLLAAGLLLIALFL 346
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
15-177 |
5.67e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.00 E-value: 5.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 15 FVMMLVILFLMEFARGMYILSYINFlpTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLF 94
Cdd:cd17370 202 FWLYLLAVALFALGNFSFAFLILRA--QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 95 LVIWFPASPFIIIfSAIMLGIAVSPIWVIMLS----SVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFLM 170
Cdd:cd17370 280 GFALGSSLWLLLL-GFILWGLYMGAQESIERAavadLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
|
....*..
gi 394268256 171 ALVVLIA 177
Cdd:cd17370 359 SAVLALI 365
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
70-383 |
2.65e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 49.14 E-value: 2.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 70 GFLLKKFGSKLVLTSGFLLaFISLFLVIWFPASPFIIIFSAIMLGIA--VSPIWVIMLSSVDERNRGKQMGYVYFSWLLG 147
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLL-FIAGSLLAAYATSIYGLILGRALQGSGaiSSVVMALLADLTREENRTKAMALIGASIGIA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 148 LLVGMVIMNLLIKFHPTRFAFLM-ALVVLIAWVLYYFVNINLTNYNTK--PVKAQLKQIVDVTQRHLILFPGILLQGAAI 224
Cdd:cd17472 132 FAISMVLGPLLAAHLGVSGLFLItAILSLVSLLILLFFVPDPPKIVQIseKEKKKLKKLLKNKRLLRLDFSIFILHFVLM 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 225 AALVpILPKYATQVV-------KVstvgYTVAIIIGGIGCAFSMLFLSKiidnnsKGFMYGVIFSGFILYTILIFGLSTI 297
Cdd:cd17472 212 AFFY-ILPLLLTQLGggkgqlwKV----YLPAILIGFILMVPFVIYAEK------KGKMKQVFVSSILLIAVGFLLLLFA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 298 TNIYIVWAIGL---FIGlmYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFtNNLNNTFYFSA 374
Cdd:cd17472 281 ATSLWLLIIGLiifFIG--FNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGL-LGYSSVFLTIL 357
|
....*....
gi 394268256 375 MIFLALAVF 383
Cdd:cd17472 358 ILALLWLLV 366
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
44-382 |
1.22e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.88 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 44 TSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLVIWFPASPFIIIFSAIMLGIAVSPIWVI 123
Cdd:cd17355 33 FGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 124 MLSSV----DERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTR-----FAFLMALVVLIAWVLY--YFVNINLTNYN 192
Cdd:cd17355 113 AFATVaawwFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRtallvLALLALLVLVPVLLLLrrRPADLALRAYD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 193 TKPVKA---QLKQIVDvTQRHLILFPGILLQGAAIAALVPILPKYATQVVkVSTVGYTVAIIIGGIGCAFSMLFLSKIID 269
Cdd:cd17355 193 DASPASpgsTLKEALR-SASFWLLALAFFLCGFAVVGLIVHLVPYLADRG-ISPAAAAVALALIGLFNIVGRLLSGWLGD 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 270 NNSKGFMYGVIFSGFILyTILIFGLSTITnIYIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGS 349
Cdd:cd17355 271 RYSPRRLLAASYALRAL-GLALLLLLPFP-PLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGS 348
|
330 340 350
....*....|....*....|....*....|...
gi 394268256 350 MIGPLVGGLITQFTNNLNNTFYFSAMIFLALAV 382
Cdd:cd17355 349 ALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
52-384 |
1.34e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 46.79 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 52 SFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLL--AFISLFLVIWFPASPFIIIFsaiMLGIAVSPIWVIMLSSVD 129
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLwsLFTALTGFATSLTSLYVLRF---LLGVAEAGFFPGAIKALA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 130 E----RNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAF----LMALVVLIAWVLYYfvninltnyntkpvkaqlk 201
Cdd:cd17319 118 EwfpaRERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFiiegLLGLLLAVLWWFYL------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 202 qivdvtQRHLILFPGILLQGAAIAALVPILPKYATQVVKVSTVGYTVAIIIGGIGCAFSMLFLSKIIDNNSKGFMYGVIF 281
Cdd:cd17319 179 ------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVII 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 282 SGFILYTILIFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQ 361
Cdd:cd17319 253 IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVD 332
|
330 340
....*....|....*....|...
gi 394268256 362 FTNNLNNTFYFSAMIFLALAVFY 384
Cdd:cd17319 333 ATGSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
67-384 |
1.56e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 67 FVIGFLLKKFGSKLVLTSGFLLAFISLFLVIWFPASPFIIIFSAIM-LGIA-VSPIWVIMLSSV-DERNRGKQMGYVYFS 143
Cdd:cd17474 52 PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQgIGAAgLGPLALTLIGDLfEGGERAKAMGLYEAA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 144 WLLGLLVGMVIMNLLIKFH---PtrFAFLMALVVLIAWVLYYFVNINLTNYNTKPVKAQLKQIVDVTQRHLILFP-GILL 219
Cdd:cd17474 132 LGLGIAVGPLLGGLLAAISwryP--FFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLvSAFL 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 220 QGAAIAALVPILPKYATQVVKVSTVGYTVAIIIGGIGCAFSMLFLSKIIDnnSKGFMYGVIFSGFILYTILIFGLSTITN 299
Cdd:cd17474 210 YFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLK--KRFGARRILVIGLLLYALSLLLLGFVPS 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 300 IYIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTnNLNNTFYFSAMIFLA 379
Cdd:cd17474 288 LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF-GLSAPFLVGAAIALA 366
|
....*
gi 394268256 380 LAVFY 384
Cdd:cd17474 367 AAVLL 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-184 |
1.58e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 15 FVMMLVILFLMEFARGMYILSYINFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGS--KLVLTSGFLLAFIS 92
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 93 LFLVIWFPASPFIIIFSAIM---LGIAVSPIWVIMLSSVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFL 169
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAgfgLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170
....*....|....*.
gi 394268256 170 -MALVVLIAWVLYYFV 184
Cdd:COG2271 342 lLAALALLAALLALLL 357
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
39-384 |
2.15e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.16 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 39 FLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLvIWFPASPFIIIFSAIMLGIAVS 118
Cdd:cd17333 21 SLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL-IFATPSIYLFVVLMFLAGLGAG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 119 PIWVIMLSSV---DERNRGKQMGYVYFSWLLGLLVGMVIMNLLIK-----FHPTRFAFLMALVVLIAWVLYYFVNINLT- 189
Cdd:cd17333 100 ILDTGANTFVgalFEESSATRLNVLHGFFGLGALIGPLIATSLLTselswSWAYLIIGLIYLLLAILILLTLFPELPSAr 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 190 NYNTKPVKAQLKQIVDVTQRHLILFP-GILLQGAAIAALVPILPKYATQV--VKVSTVGYTVAIIIGGIgcAFSMLFLSK 266
Cdd:cd17333 180 NPQQSVGAFSASASRLLRNPSIILGAlALFLYVGAETAFSSWVPSYLVEKkhVSDGLAGYLLSGFWVGI--TIGRLLGGP 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 267 IIDN-NSKGFMYGVIFSGFILYTILIFGLSTITNIYIVWAIGLFIGLMYGILLPawntfMAGHINPNEQEETWGVFNSVQ 345
Cdd:cd17333 258 ISRRiKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILS-----LGISNLPYAKGKGTSVLLAAG 332
|
330 340 350
....*....|....*....|....*....|....*....
gi 394268256 346 GFGSMIGPLVGGLITQFTnNLNNTFYFSAMIFLALAVFY 384
Cdd:cd17333 333 SIGGAIIPFIMGFIAEAV-GIQTAMLLITILYAIIFVLA 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-159 |
2.17e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.01 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 15 FVMMLVILFLMEFARGMYILSYINFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLF 94
Cdd:cd17321 170 FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 394268256 95 LVIWFPASPFIIIFSAIM------LGIAVSPIWVIMLSSVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLI 159
Cdd:cd17321 250 LLALLGADSSVWLLLPGLvllglgLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
79-384 |
2.40e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 79 KLVLTSGFLLAFISLFLVIWFP---ASPFIIIFSAIMLGIA---VSPIWVIMLSS-VDERNRGKQMGYVYFSWLLGLLVG 151
Cdd:cd06173 65 RLLILADLLRALLAAVLALLALlgsLSLWLLLVLAFLLGIAsafFGPARQALLPElVPKEQLVRANALNSLATQLARIIG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 152 MVIMNLLIKFHPTRFAFLMALVV-LIAWVLYYFVNINLTNYNTKPVKAQLKQIVD---VTQRHLILFPGILLQGA---AI 224
Cdd:cd06173 145 PALGGLLVALLGPGGAFAINALSfLLSALLLLFIRRPPPAAPGESSSLLLRDLREglrYLRRSPLLRLLLLALALfalLG 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 225 AALVPILPKYATQVVKVSTVGYTVAIIIGGIGCAFSMLFLSKIIDNNSKGFMygvIFSGFILYTILIFGLSTITNIYIVW 304
Cdd:cd06173 225 GALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRL---LLIGALLLGLALLVLGLSPSLWLLL 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 305 AIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTnNLNNTFYFSAMIFLALAVFY 384
Cdd:cd06173 302 AALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL-GLSAVFLLAGALLLLAALLL 380
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-147 |
3.78e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 3.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 15 FVMMLVILFLMEFARGMYILSYINFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLF 94
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 394268256 95 LVIWFPASPFIIIFSAIM---LGIAVSPIWVIMLSSVDERNRGKQMGYVYFSWLLG 147
Cdd:COG2814 289 LLALAGSLWLLLLALFLLgfgFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
15-184 |
9.09e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.14 E-value: 9.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 15 FVMMLVILFLMEFArGMYILSYI-NFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISL 93
Cdd:cd17353 215 FWLLWLMFFLNATA-GLMLIGQAkPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAM 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 94 FLVIWFPASPFIIIFSAIMLGIAVSPIWVIMLSSVD----ERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFL 169
Cdd:cd17353 294 FLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTAdffgTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFI 373
|
170
....*....|....*.
gi 394268256 170 MALVV-LIAWVLYYFV 184
Cdd:cd17353 374 IAAALsLVALALALLL 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
211-383 |
1.72e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.42 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 211 LILFPGILLQGAAIAALVPILPKYATQVvKVSTVGYTVAIIIGGIGCAFSMLFLSKIIDNNSKgfmYGVIFSGFILYTIL 290
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR---RRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 291 IFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTnNLNNTF 370
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWVF 167
|
170
....*....|...
gi 394268256 371 YFSAMIFLALAVF 383
Cdd:COG2814 168 LVNAVLALLALLL 180
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
16-184 |
1.78e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.37 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 16 VMMLVILFLMEFARGMYILSYINFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFL 95
Cdd:cd06173 211 RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLV 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 96 VIWFPASPFIIIFSAIM---LGIAVSPIWVIMLSSVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFLMAL 172
Cdd:cd06173 291 LGLSPSLWLLLAALFLLglaGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAG 370
|
170
....*....|..
gi 394268256 173 VVLIAWVLYYFV 184
Cdd:cd06173 371 ALLLLAALLLLL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
213-384 |
2.53e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 2.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 213 LFPGILLQGAAIAALVPILPKYATQVVKVSTVGYTVAIIIGGIGCAFSMLFLSKIIDNNSKGFMYGVifsGFILYTILIF 292
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI---GLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 293 GLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTnNLNNTFYF 372
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAFLI 156
|
170
....*....|..
gi 394268256 373 SAMIFLALAVFY 384
Cdd:pfam07690 157 LAILSLLAAVLL 168
|
|
| ATG22 |
pfam11700 |
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ... |
234-384 |
3.58e-04 |
|
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.
Pssm-ID: 371676 Cd Length: 479 Bit Score: 42.64 E-value: 3.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 234 YATQVVKVSTVGYTVAIIIGGI-GC--AFSMLFLSKIIDNNSKGFMYG--VIFSGFILYTILIFGLSTI--TNIYIVWAI 306
Cdd:pfam11700 309 FAKTELGMSTSQLTLLNIVAMIaAVlgAFLWPFVSRRFNLKTKQTLIAciVLFELIPLYGLLGIILGKIglKNPWEFWVL 388
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 394268256 307 GLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTNNLNNTFYFSA-MIFLALAVFY 384
Cdd:pfam11700 389 QAFYGLVLGGLRSYSRSLYSELIPRGKEAQFFSLYAITDKGSSWIGPLIVGAIQDRTGNIRSPFVFLAiLLVVPLPLLL 467
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
145-383 |
3.81e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.45 E-value: 3.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 145 LLGLLVGMVIMN----LLIKFHPTRFAFLMALVVLIAWVLYYFVNINLTNYNTK-----PVKAQLKQIVDV-----TQRH 210
Cdd:COG2270 160 LLLINLALFLKPeafgLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGPapprgAVRAGFRELRRTlrelrRYRD 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 211 LILFpgiLLQGA----AIAALVPILPKYATQVVKVSTVGYTVAIIIG---GIGCAFSMLFLSKIIDNNSkgfmygVIFSG 283
Cdd:COG2270 240 LLRF---LLAYFfyrdGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVqivAALGALLFGRLDDRIGPKR------VILVS 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 284 FILYTILIFGLSTITNIYIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFT 363
Cdd:COG2270 311 LVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLT 390
|
250 260
....*....|....*....|
gi 394268256 364 NNLNNTFyFSAMIFLALAVF 383
Cdd:COG2270 391 GSQRLGI-LSLIVFFVIGLV 409
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
15-161 |
6.03e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 6.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 15 FVMMLVILFLMEFARGMYILSYINFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLF 94
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 394268256 95 LVIWF-PASPFIIIFSAIMLGIAVSPIWVIMLS----SVD-------ERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKF 161
Cdd:COG2211 310 LLFFLgPGNLWLLLVLAALAGIGLGAILVLPWAmladVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLAL 388
|
|
| MFS_Atg22_like |
cd17483 |
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily ... |
234-383 |
6.44e-04 |
|
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily of transporters; Atg22 (also known as Aut4) protein functions as a vacuolar effluxer which mediates the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation. Members of this family belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341036 Cd Length: 467 Bit Score: 41.87 E-value: 6.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 234 YATQVVKVSTVGYTV----AIIIGGIGCAFSMLFLSKIIDNNSKGFMYGVIFSGFI-LYTIL-----IFGLSTITNIYIV 303
Cdd:cd17483 302 FAKSQLHMSTLQLILigllTPITAILGAFFFPRIQRRFNLSTKTMLMLIVVLTALIpLYGLLgfftgKFGLKHPWEMYVL 381
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 304 waiGLFIGLMYGILLpAWNTFMAGHINPNEQEETWGVFNSVQGFGS-MIGPLVGGLITQFTNNLNNTFYF-SAMIFLALA 381
Cdd:cd17483 382 ---AVWFGFFLGGLQ-SYSRSLFSELIPPGHEAEFFSLFSITDKGSsWIGPLVVGAIIDATGNIRYGFIFlFALFVLPLP 457
|
..
gi 394268256 382 VF 383
Cdd:cd17483 458 LL 459
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
129-384 |
7.55e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 41.47 E-value: 7.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 129 DERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFLMALVVLIAWVLYYFV--NINLTNYNTKPVKAQLKQIVdv 206
Cdd:cd17388 120 PPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVlpESLPPERRRAFRWRRANPFG-- 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 207 TQRHLILFPGIL----------LQGAAIAALVPILPKYATQVVKVsTVGYTVAIIigGIGCAFSMLFLSKIIdnNSKGFM 276
Cdd:cd17388 198 SLRWLTGFPGLLgllavffliqLIGQVPATTWVLFTEDRFDWSPT-MVGLSLAVF--GLLHALFQAFVTGPI--AKRLGE 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 277 YGVIFSGFILYTILIFGLSTITNIYIVWAIgLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVG 356
Cdd:cd17388 273 KRAILLGLAADALGFLLLAFATQGWMVFPI-LILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLF 351
|
250 260
....*....|....*....|....*...
gi 394268256 357 GLITQFTnnlnnTFYFSAMIFLALAVFY 384
Cdd:cd17388 352 TGIFAAS-----PATWPGLAWIIGAALY 374
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
68-384 |
7.88e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.38 E-value: 7.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 68 VIGFLLKKFGSKLVLTSGFLLAFISLFLVIWFPASPFIIIFSAIMLGIAVSPIW---VIMLSSVDERNRGKQMGYVYFSW 144
Cdd:cd17352 57 LSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYspaIVIVGQYFEKKRGLATGIAVAGS 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 145 LLGLLVGMVIMNLLIKFHPTRFAFL----MALVVLIAWVLYYFvninltnyntkpvkaqLKQIVdvtqrHLILFPGILLQ 220
Cdd:cd17352 137 GVGTFVFPPLLRYLLDNYGWRGALLilggLCLNLCVCGLLLRL----------------LKDPT-----FVLLALGVSFA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 221 GAAIAALVPILPKYATQVVKVSTVGYTVAIIIGGIGcAFSMLFLSKIIDNNSKGFMYGVIFSGFILyTILIFGLSTITNI 300
Cdd:cd17352 196 MLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISD-IVGRILLGLLADKPRIGRLYLYIFTLLIL-GLSLLAFPLATTY 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 301 YIVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIGPLVGGLITQFTNNLNNTFYFSAMIFLAL 380
Cdd:cd17352 274 VGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLS 353
|
....
gi 394268256 381 AVFY 384
Cdd:cd17352 354 GVLL 357
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
19-180 |
1.42e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 19 LVILFLMEFARGMYILSYINFLP---TVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFL 95
Cdd:cd17478 197 LLLLLIIVFLRSWVLSSLTTFLPfylVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 96 VIWFPASPFIIIFSAIMLGIAVS-PIWVIMLSSVDERNRGKQMGYVY-FSWLLGLLVGMVIMNLLIKFHPTRFAFLMALV 173
Cdd:cd17478 277 FLLTPGIWSYILLVLAGFLLFASfPVTVVLAQELLPGNVGLASGLMMgLSFGLGGIGAPVLGALADAFGLESVLLILALL 356
|
....*..
gi 394268256 174 VLIAWVL 180
Cdd:cd17478 357 PLLGALL 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
15-181 |
1.89e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 40.25 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 15 FVMMLVILFLMEFARGMYILSYINFLPTVTSIAIAITSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLF 94
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 95 LVIWFPASPFIIIFSAIMLGIAV----SPIWVIMLSSVDERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTR----- 165
Cdd:COG2223 287 LLALALGSLWLFLVLFLLLGLALgggnGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYtaafl 366
|
170
....*....|....*..
gi 394268256 166 -FAFLMALVVLIAWVLY 181
Cdd:COG2223 367 vFAVLALVALVLTLLLY 383
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
70-383 |
3.64e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.10 E-value: 3.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 70 GFLLKKFGSKLVLTSGFLLAFISLFLVIWFPASPFIIIFSAImLGIAVSPIW----VIMLSSVDERNRGKQMGYVYFSWL 145
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRIL-QGFGGGVLIplaqTILLRIYPPEKRGAAMGLVGLVIL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 146 LGLLVGMVIMNLLIKFHPTRFAFLMAL-VVLIAWVLYYFVNINLtnyntkpvkaqLKqiVDVTQRHLILfpgILLQGAAI 224
Cdd:cd17503 131 LAPAIGPTLGGWLTDNLSWRWIFYINLpIGILALLLAPLLDLRL-----------FK--DRNFTLGLLL---SFLLGLGL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 225 AALVPILPKYATQVVKVSTVGYTVAIIIGGIGCAFSMLFLSKIIDnnsKGFMYGVIFSGFILY---TILIFGLSTITNIY 301
Cdd:cd17503 195 FGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLD---KFGPRLLLLAGLLLLalgTLLLAFLTPDTSLW 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 302 IVWAIGLFIGLMYGILLPAWNTFMAGHINPNEQEETWGVFNSVQGFGSMIG-PLVGGLITQFTNN--------------- 365
Cdd:cd17503 272 LIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGtALLATLLTNRTQFhhsrlsellaqqvqk 351
|
330 340
....*....|....*....|....
gi 394268256 366 ------LNNTFYFSAMIFLALAVF 383
Cdd:cd17503 352 qaliiaFNDAFLVSAILLLVGLLL 375
|
|
| DotA_TraY |
TIGR04346 |
conjugal transfer/type IV secretion protein DotA/TraY; Members of this protein family include ... |
61-174 |
6.66e-03 |
|
conjugal transfer/type IV secretion protein DotA/TraY; Members of this protein family include transfer protein TraY of IncI1 plasmid R64 and DotA (defect in organelle trafficking A) of Legionella pneumophila.
Pssm-ID: 275142 Cd Length: 652 Bit Score: 38.53 E-value: 6.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 61 ADAATNFVIGFLLKkFGSKLVLTSGFLLAFISLFLVIWFPASPFIIIFSAI-------MLGIAVSPIWVIMLSSVD-ERN 132
Cdd:TIGR04346 478 FVGGGAAALSGLLS-AISFVLFPLALALFIMGLILAYYLPFIPFIIWMGAVvgwlilvVEAVVAAPLWALAHLLPEgDGL 556
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 394268256 133 RGKQMGYVY---FSWLL-------GLLVGMVIMNLLIKFHPTRFAFLMALVV 174
Cdd:TIGR04346 557 AGQRAGQGYlllLSILLrpplmviGFFAAILLSDVIGTLLNKLFAIALANVQ 608
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
33-383 |
8.81e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 37.93 E-value: 8.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 33 ILSYINFLPTVTSIAIAI-------------TSFAFSIHFIADAATNFVIGFLLKKFGSKLVLTSGFLLAFISLFLVIWF 99
Cdd:COG2807 24 VLVALNLRPAITSVGPLLpeiradlglsatqAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 100 PASPFIIIFSAIM-LGIAVSPIWVIMLSSVD-ERNRGKQMGYVYFSWLLGLLVGMVIMNLLIKFHPTRFAFLM----ALV 173
Cdd:COG2807 104 PSVALLLAGTALIgAGIAVGNVLLPGLIKRWfPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVwallALL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 174 VLIAWVLyyFVNINLTNYNTKPVKAQLKQIV-DVTQRHLILFPGilLQGAAIAALVPILPKYATQV-VKVSTVGYTVAII 251
Cdd:COG2807 184 ALLLWLP--LLRRRPAAAAAAPAAASLRSLWrSPLAWLLTLFFG--LQSLLYYAVVAWLPPILRDAgLSAATAGLLLSLF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394268256 252 -IGGIGCAFSMLFLSKIIDNnSKGFMYGVIFSGFILYTILIFGLSTITniyIVWAIglFIGLMYGILLPAWNTFMAGHIN 330
Cdd:COG2807 260 qLAGIPGSLLVPLLADRLGD-RRPLLLLLGLLGLAGLLGLLLAPGSLP---WLWAV--LLGLGQGGLFPLALTLIGLRAR 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 394268256 331 PNEQEETW-GVFNSVQGFGSMIGPLVGGLITQFTNNLNNTFYFSAMIFLALAVF 383
Cdd:COG2807 334 TPAEAAALsGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| |
