|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
14-389 |
1.54e-93 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 285.21 E-value: 1.54e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 14 FVVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDtHHLNRKILIITALFMGAVSFSI 93
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSD-RGGDRKPLILLALLAGALGYLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 94 YFYVHQIWLFIVLYALFQGLFAPAMPQLYASARESINASSSRDrAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLF 173
Cdd:cd17471 80 FAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRSSGRD-ATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 174 GGTIAIILFTLILQVFFYKNLPVKNQISEQQHIEKIAPnmfKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEKER 253
Cdd:cd17471 159 LLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAP---VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSES 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 254 YVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYFQD 333
Cdd:cd17471 236 WVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQD 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 394281562 334 ILPDFPGYASTLFANAMVIGQLGGNLLGGVMSHWVGLENVFFVSASSIFVGMILIL 389
Cdd:cd17471 316 LMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| 2A0120 |
TIGR00899 |
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, ... |
14-393 |
2.31e-30 |
|
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, a-methyl glucoside and other sugar compounds. They are found in both gram-negative and gram-postitive bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 129977 Cd Length: 375 Bit Score: 119.88 E-value: 2.31e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 14 FVVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHlNRKILIITALFMGAVSFSI 93
Cdd:TIGR00899 2 FLLVAFLTGIAGALQFPTLSLFLSEEVRARPAMIGLFYTGSAIVGIAVSQLLATRSDYQG-DRKGLILFCCLLAALACLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 94 YFYVHQIWLFIVLYALFQGLFAPAMPQLYASARESINaSSSRDRAKFAnTVLRSMFSLGFLFGPFIGAQLIELKGYSGLF 173
Cdd:TIGR00899 81 FAWNRNYFLLLVLGVLLSSFASTANPQLFALAREHAD-RTGREAVMFS-SVMRAQISLAWVIGPPLAFWLALGFGFTVMF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 174 GGTIAIILFTLILQVFFYKNLPvKNQISEQQHIEkiAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEKER 253
Cdd:TIGR00899 159 LTAALAFVLCGVLVWLFLPSYP-RGAPGALTRLE--VRGLLASRDTRLLFVACTLMWGCNILYIINMPLLIIHELGLPDK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 254 YVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYFQD 333
Cdd:TIGR00899 236 LAGLMMGTAAGLEIPFMLLAGYLIKRFGKRRLMLLAALAGVAFYTGLAADNSLWALLMLQLLNAIFIGILAGIGMLYFQD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 334 ILPDFPGYASTLFANAMVIGQLGGNLLGGVMSHWVGLENVFFVSASSIFVGMILILFTKD 393
Cdd:TIGR00899 316 LMPGRAGAATTLYTNTGRVGWIIAGSVGGILAERWSYHAVYWFAIVMLIVALFCLLLIKD 375
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-392 |
3.11e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 105.74 E-value: 3.11e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 14 FVVNMLLLGMGIAVTVPYLILFAtKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILIITALFMGAVSFSI 93
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD--RFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 94 YFYVHQIWLFIVLYALFQGLFAPAMPQLYASAresINASSSRDRAKfANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLF 173
Cdd:cd17325 78 FAFATSYWQLLLARFLQGLASAAVWPAAMALI---ADIAPPEERGR-AMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 174 GGTIAIILFTLILQVFFYK--NLPVKNQISEQQHIEKIAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEK 251
Cdd:cd17325 154 LVCAALALLALVLALLLLPepRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 252 ERYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYF 331
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 394281562 332 QDILPDFP-GYASTLFANAMVIGQLGGNLLGGVMSHWVGLENVFFVSASSIFVGMILILFTK 392
Cdd:cd17325 314 ADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK15011 |
PRK15011 |
sugar efflux transporter SetB; |
14-393 |
8.86e-25 |
|
sugar efflux transporter SetB;
Pssm-ID: 184973 Cd Length: 393 Bit Score: 104.57 E-value: 8.86e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 14 FVVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHlNRKILIITALFMGAVSFSI 93
Cdd:PRK15011 20 FLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRG-DRKSLIVFCCLLGVLACTL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 94 YFYVHQIWLFIVLYALFQGLFAPAMPQLYASAREsiNASSSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLF 173
Cdd:PRK15011 99 FAWNRNYFVLLFVGVFLSSFGSTANPQMFALARE--HADKTGREAVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVMY 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 174 -GGTIAIILFTLILQVFF---YKNLPVKNQISEqqhiekiAPNMFKDKSLFIpFIAFILLHIGQWMYTMNMPLFVTDYLN 249
Cdd:PRK15011 177 lSAAVAFIVCGVMVWLFLpsmRKELPLATGTLE-------APRRNRRDTLLL-FVICTLMWGTNSLYIINMPLFIINELH 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 250 EKERYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGIS 329
Cdd:PRK15011 249 LPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVAGVCFYAGMLMAHSPAILLGLQLLNAIYIGILGGIGML 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 394281562 330 YFQDILPDFPGYASTLFANAMVIGQLGGNLLGGVMSHWVGLENVFFVSASSIFVGMILILFTKD 393
Cdd:PRK15011 329 YFQDLMPGQAGSATTLYTNTSRVGWIIAGSLAGIVAEIWNYHAVFWFALVMIIATLFCLLRIKD 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-337 |
2.56e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 93.89 E-value: 2.56e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 13 LFVVNMLLLGMGIAVTVPYLILFAtKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILIITALFMGAVSFS 92
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD--RFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 93 IYFYVHQIWLFIVLYALfQGLFAPAMPQLYASAresINASSSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGL 172
Cdd:COG2814 91 LCALAPSLWLLLAARFL-QGLGAGALFPAALAL---IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 173 FGGTIAIILFTLILQVFFYKNLPVknqiSEQQHIEKIAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEKE 252
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLPESRP----AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 253 RYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYFQ 332
Cdd:COG2814 243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
....*
gi 394281562 333 DILPD 337
Cdd:COG2814 323 ELAPP 327
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
15-318 |
1.87e-19 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 89.21 E-value: 1.87e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 15 VVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILIITALFMGAVSFSIY 94
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLAD--RFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 95 FYVHQIWLFIVLYAL---FQGLFAPAMpqlyasaRESINASSSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELkGYSG 171
Cdd:cd17329 83 GFAHSPWLFAIALVLtgfGGGLFEPAS-------EAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 172 LFGGTIAIILFTLILQVFFYKNLPVKNQISEQQHIEKIAPNMFKDKSLFIPFIAFIL--LHIGQWMYTmnMPLFVTDYLN 249
Cdd:cd17329 155 LFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLisLIYFQLEST--LPVYVVEILG 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 394281562 250 EKERYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAI 318
Cdd:cd17329 233 LGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTL 301
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-336 |
1.43e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 80.15 E-value: 1.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 14 FVVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILIITALFMGAVSFSI 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD--RFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 94 YFYVHQIWLFIVLYALfQGLFAPAMpqlYASARESINASSSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLF 173
Cdd:pfam07690 79 LLFASSLWLLLVLRVL-QGLGAGAL---FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 174 GGTIAIILFTLILQVFF--YKNLPVKNQISEQQHIEKIAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYlNEK 251
Cdd:pfam07690 155 LILAILSLLAAVLLLLPrpPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 252 ERYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLII---GSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGI 328
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLallLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313
|
....*...
gi 394281562 329 SYFQDILP 336
Cdd:pfam07690 314 ALVSDLAP 321
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-336 |
1.45e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 77.61 E-value: 1.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 18 MLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALA----AISQFIVNSIIARFSDthhlnRKILIITALFMGAVSFSI 93
Cdd:COG2223 13 AFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPvlvgALLRIPLGFLVDRFGP-----RRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 94 YFyVHQIWLFIVlYALFQGLFAPAMpqlYASARESINASSSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLF 173
Cdd:COG2223 88 AL-AVSYWLLLL-LGLLLGIGGGGS---FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 174 GGTIAIILFTLILQVFFYKNLPVKNQISEQQHIEKIAPnMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEKER 253
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE-ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 254 YVGYLASLCAGLEVPFMVILGILSAKL-PTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYFQ 332
Cdd:COG2223 242 TAGLLAALFALLGALGRPLGGWLSDRIgGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVP 321
|
....
gi 394281562 333 DILP 336
Cdd:COG2223 322 DIFP 325
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-336 |
1.75e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 77.63 E-value: 1.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 19 LLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSD---THHLNRKILIITALFMGAVSFSIYF 95
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrTRWGRRRPWILIGAIPLALSFVLLF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 96 YVH------QIWLFIVLYALFQGLFAPAMPQLYASARESinASSSRDRAKfANTVLRSMFSLGFLFGPFIGAQLIEL--- 166
Cdd:COG2211 100 TAPdlsptgKLIYALVTYLLLGLAYTLVNIPYSALGAEL--TPDYEERTR-LSSWRFAFAGLGGLLASVLPPPLVAAfgg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 167 ---KGYSGLFGGTIAIILFTLILQVFFYKNLPVKNQisEQQHIEKIAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLF 243
Cdd:COG2211 177 daaLGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE--EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYY 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 244 VTDYLNEKERYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFK--NFHMMLVGQICLAIFLA 321
Cdd:COG2211 255 FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLG 334
|
330
....*....|....*
gi 394281562 322 ILLGLGISYFQDILP 336
Cdd:COG2211 335 AILVLPWAMLADVVD 349
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-389 |
4.95e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 72.84 E-value: 4.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 14 FVVNMLLLGMGIAVTVPYLILFAtKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILIITALFMGAVSFSI 93
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLLAD--RFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 94 YFYVHQIWLFIVLYALFQGLFAPAMPQLYASARESINASssrdRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLF 173
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPER----ERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 174 GGTIAIILFTLILQVFFYKNLPVKNQISEQQHIEKIAPNM------FKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDY 247
Cdd:cd06174 154 VFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLkllkrvLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 248 LNEKERYVGYLASLCAGLEVPFMVILGILSAK-LPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGL 326
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 394281562 327 GISYFQDILPdfPGYASTLFANAMVIGQLGGNLLGGVMSHWV----GLENVFFVSASSIFVGMILIL 389
Cdd:cd06174 314 SFALIAELFP--PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaatfGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-392 |
1.20e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.73 E-value: 1.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 18 MLLLGMGIAVTVPyLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFsdTHHLNRKILIITALFMGAVSFSIYFYV 97
Cdd:COG0738 17 FFLWGFATALWGP-LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRL--IDRFGYKRGLLLGLLLMALGLLLFALA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 98 HQIWLFIV---LYALFQGLFAPAMpQLYASAREsinasssRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLFG 174
Cdd:COG0738 94 PSYPLLLLalfLLGLGLGLLDVAA-NPYVAALG-------PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 175 GTIAIILFTLILQVFFYK-NLP-VKNQISEQQHIEKIAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEKE 252
Cdd:COG0738 166 PYLILAVLLLLLALLFLRsKLPeIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 253 RYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYFQ 332
Cdd:COG0738 246 ATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 333 DILPDFPGYASTLFANAMVIGQLGGNLLGGVMSHWVGLENVFFVSASSIFVGMILILFTK 392
Cdd:COG0738 326 DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-390 |
1.45e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 65.28 E-value: 1.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 8 IKNYKLFVVNMLLLGMGIA----VTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILIITA 83
Cdd:COG2271 4 PSRYRWRILALLFLAYFLNyldrSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD--RFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 84 LFMGAVSFSIYFYVHQIWLFIVLYAL---FQGLFAPAMPQLyasaresINASSSRDRAKFANTVLRSMFSLGFLFGPFIG 160
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLlglGEAGFFPAALKL-------IAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 161 AQLIELKGYSGLFGGTIAIILFTLILQVFFYknlpvknqiseqqhiekiapnmfkdkslfipFIAFILLHIGQWMYTMNM 240
Cdd:COG2271 155 GWLLAAFGWRAAFLILGLPGLLLALLRFWLL-------------------------------ALAYFLVYFALYGFLTWL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 241 PLFVTDYLNEKERYVGYLASLCAGLEVPFMVILGILSAKL--PTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAI 318
Cdd:COG2271 204 PTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGF 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 394281562 319 FLAILLGLGISYFQDILP-DFPGYASTLFANAMVIGQLGGNLLGGVMSHWVGLENVFFVSASSIFVGMILILF 390
Cdd:COG2271 284 GLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-191 |
9.01e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.98 E-value: 9.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 2 FTALLQIKNYKLFVVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHhlNRKILII 81
Cdd:cd17325 192 LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI--GRKPLIL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 82 TALFMGAVSFSIYFYVHQIWLFIVLYALFQGLFAPAMPqlyASARESINASSSRDRAKfANTVLRSMFSLGFLFGPFIGA 161
Cdd:cd17325 270 IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFP---ATLALLADIVPPEGRGT-AMGLFNTAFSLGMVLGPLLGG 345
|
170 180 190
....*....|....*....|....*....|
gi 394281562 162 QLIELKGYSGLFGGTIAIILFTLILQVFFY 191
Cdd:cd17325 346 FLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
18-391 |
2.15e-10 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 61.90 E-value: 2.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 18 MLLLGMGIAVTVPYLILFaTKDLGMTTTQY-----GLLLALAAISQFIVNSIIARFSDTHhlNRKILIITALFMGAVSFS 92
Cdd:cd17391 5 NFFTGIGFSLIAPFLPLY-IEQLGVTSGGLvelwsGLAFSSTFLVSAIFSPIWGRLADRY--GRKPMLLRASLGMAIVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 93 IYFYVHQIWLFIVLyALFQGLFAPAMPqlyaSARESINASSSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGL 172
Cdd:cd17391 82 LMAFVTNVWQLLIL-RLLQGVFSGYVP----NATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 173 FGGTIAIILFTLILQVFFYKNLPVKNQISEQQHIEKIAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDyLNEKE 252
Cdd:cd17391 157 FFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQ-LMGDA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 253 RYVGYLASLCAG-------LEVPFmviLGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLG 325
Cdd:cd17391 236 SNLAFISGLVFSatgvsslLSAPR---LGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLP 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 394281562 326 LGISYFQDILPDfpGYASTLFA---NAMVIGQLGGNLLGGVMSHWVGLENVFFVSASSIFVGMILILFT 391
Cdd:cd17391 313 AINSLLAKITPK--EVAGRIFGynqSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIF 379
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
27-390 |
1.64e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.17 E-value: 1.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 27 VTVPYLILFATKDLGMTttqyGLLLALAAISQFIVNSIIARFSDTHHLnRKILIITALFMGAVSFSI----YFYVHQIWL 102
Cdd:cd06173 20 VALPWLVLQLTGSALLV----GLVLAAFFLPFLLFSPFAGVLADRFDR-RRLLILADLLRALLAAVLallaLLGSLSLWL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 103 FIVLYALFQGLFAPAMPQLYASaresINASSSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLFGGTIAIILF 182
Cdd:cd06173 95 LLVLAFLLGIASAFFGPARQAL----LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 183 TLILQVFFYKNLPVKNQISEQQHIEKIAPNMF---KDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEKERYVGYLA 259
Cdd:cd06173 171 SALLLLFIRRPPPAAPGESSSLLLRDLREGLRylrRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 260 SLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYFQDILPD-F 338
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDeL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 394281562 339 PGYASTLFANAMVIGQLGGNLLGGVMSHWVGLENVFFVSASSIFVGMILILF 390
Cdd:cd06173 331 RGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-323 |
1.92e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 58.74 E-value: 1.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 20 LLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILIITALFMGAVSFSIYFYVHQ 99
Cdd:cd17330 9 ALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSD--RYGRKPVLLLSLAGSAVSYVLLGLSRN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 100 IWLFIV---LYALFQGLFAPAmpQLYASAresinASSSRDRAKfANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLFGGT 176
Cdd:cd17330 87 LWLLFLarfLDGLTGGNVSVA--QAYIAD-----ITDEEERAK-AFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 177 IAIILFTLILQVFFYKNLPVknqiseqqhiekiapnmfkdkslfiPFIAFILLHIGQWMYTMNMPLFVTDYLNEKERYVG 256
Cdd:cd17330 159 AALALLNLVLVLFFLPPLRR-------------------------LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIG 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 394281562 257 YLASLC-AGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAIL 323
Cdd:cd17330 214 LLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIV 281
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
24-345 |
1.28e-08 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 56.44 E-value: 1.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 24 GIAVTVPYLILFAtKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHLNRKILIITALFMGAVSFSIYFYVHQIWLF 103
Cdd:cd17335 12 ALGSLLPFLSVYL-KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQIFWLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 104 IVLYALFQGLFAPAMPQLYASAresiNASSSRDRAKFANTvlRSMFSLGFLFGPFIGAQLIE----LKGYSGLFGGTIAI 179
Cdd:cd17335 91 LLLVILGAFFSAPVVPLVDSIT----LQYLGEERERYGKQ--RLWGSIGFGIAALLVGILIDrsstYKNYTIAFYVFAVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 180 ILFTLILQVFFyknlPVKNQISEQQHIEKIAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDyLNEKERYVGYLA 259
Cdd:cd17335 165 MLLALLLALKF----PFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQD-LGGSKTLIGLLW 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 260 SLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYFQDILPdfP 339
Cdd:cd17335 240 TVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAP--P 317
|
....*.
gi 394281562 340 GYASTL 345
Cdd:cd17335 318 GLRATA 323
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-389 |
1.64e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.02 E-value: 1.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 38 KDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILIITALFMGAVSFSIYFYVHQIWLFIVLyALFQGLFAPA 117
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSD--RIERRRLLLVLLLLFILGNLLAALAPSFALLLLA-RALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 118 MPQLYASAresINASSSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLFGGTIAIILFTLILQVFFYKNLPVK 197
Cdd:cd17324 104 FWAIAAAY---AADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 198 NQISEQQHIEKIApnMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEKERYVGYLASLCAGLEVPFMVILGILS 277
Cdd:cd17324 181 KPGSLGLLSSLLL--LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 278 AKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYFQDILPDFPGYASTLFANAMVIGQLGG 357
Cdd:cd17324 259 DRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALG 338
|
330 340 350
....*....|....*....|....*....|..
gi 394281562 358 NLLGGVMSHWVGLENVFFVSASSIFVGMILIL 389
Cdd:cd17324 339 AALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-392 |
1.69e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.68 E-value: 1.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 15 VVNMLLLGMGIAVTVPYLILFAtKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDThhLNRKILIITALFMGAVSFSIY 94
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYA-HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDR--FGRKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 95 FYVHQIWLFIV---LYALFQGLFAPAMPQLYASaresINASSSRDRAKFANTVlrsMFSLGFLFGPFIGAQLIELKGYSG 171
Cdd:cd17489 79 LLATSVALLLVlrlIHGIGWGAFTTAAATLVAD----IIPPSRRGEGIGYYGL---ATTLAMALGPALGLFLYQHLGFAV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 172 LFGGTIAIILFTLILQVFFYKNLPVKNQISEqqhIEKIAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEk 251
Cdd:cd17489 152 LFIVAAVLALLALLLVFLVKDPPPVAAEEAE---AGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 252 erYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAI-FLAILLGLGISY 330
Cdd:cd17489 228 --NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLgFGLLFPALQALA 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 394281562 331 FQDILPDFPGYASTLFANAMVIGQLGGNLLGGVMSHWVGLENVFFVSASSIFVGMILILFTK 392
Cdd:cd17489 306 VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
72-336 |
2.01e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 52.71 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 72 HHLNRKILIITALFMGAVSFSIYFYVHQIWLFIVLYALFqglfAPAMPQLYASARESINASSSRDRAkFANTVLRSMFSL 151
Cdd:cd17333 56 KRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLA----GLGAGILDTGANTFVGALFEESSA-TRLNVLHGFFGL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 152 GFLFGPFIGAQLIELK---GYSGLFGGTIAIILFTLILQVFFYKNLPVKNQISEQQHIEKIAPNMFKDKSLFIPFIAFIL 228
Cdd:cd17333 131 GALIGPLIATSLLTSElswSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 229 LHIGQWMYTMNMPLFVTDYLNEKERYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHM 308
Cdd:cd17333 211 YVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVV 290
|
250 260
....*....|....*....|....*...
gi 394281562 309 MLVGQICLAIFLAILLGLGISYFQDILP 336
Cdd:cd17333 291 GLVATALLGLFMAALFPTILSLGISNLP 318
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-195 |
4.21e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.41 E-value: 4.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 13 LFVVNMLLLGMGIAVTVpYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHLNRKILIITALFMGAVSFS 92
Cdd:COG2271 185 LALAYFLVYFALYGFLT-WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 93 IYFYVHQIWLFIVLYALFQGLFAPAMPQLYASARESInassSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGL 172
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF----PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|...
gi 394281562 173 FGGTIAIILFTLILQVFFYKNLP 195
Cdd:COG2271 340 FLLLAALALLAALLALLLLRETR 362
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-186 |
8.38e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 8.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 1 MFTALLQIKNYKLFVVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILI 80
Cdd:COG2211 220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAK--RFGKKKAF 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 81 ITALFMGAVSFSIYFYV--HQIWLFIVLYAL---FQGLFAPAMPQLYASARESINASSSRDRAKFANTVLRSMFSLGFLF 155
Cdd:COG2211 298 IIGLLLAALGLLLLFFLgpGNLWLLLVLAALagiGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQAL 377
|
170 180 190
....*....|....*....|....*....|....*....
gi 394281562 156 GPFIGAQLIELKGY--------SGLFGGTIAIILFTLIL 186
Cdd:COG2211 378 AGALAGLLLALFGYvagaaqspSALTGIRLLFFLLPAVL 416
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-128 |
9.30e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.36 E-value: 9.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 2 FTALLQIKNYKLFVVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILII 81
Cdd:COG2814 200 LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLL 277
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 394281562 82 TALFMGAVSFSIYFYVHQIWLFIVLYALFQGLFAPAMPQLYASARES 128
Cdd:COG2814 278 IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
13-186 |
7.18e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 7.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 13 LFVVNMLLLGMGIAVTVPyLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILIITALFMGAVSFS 92
Cdd:cd06173 213 LLLALALFALLGGALTVL-LPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSK--RRRRGRLLLIGALLLGLALL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 93 IYFYVHQIWLFIVLYALFQGLFAPAMPQLYASARESINAsssRDRAKfANTVLRSMFSLGFLFGPFIGAQLIELKGYSGL 172
Cdd:cd06173 290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPD---ELRGR-VFSVYNALNSGAMPLGALLAGLLADALGLSAV 365
|
170
....*....|....
gi 394281562 173 FGGTIAIILFTLIL 186
Cdd:cd06173 366 FLLAGALLLLAALL 379
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
29-346 |
7.44e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 7.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 29 VPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHLNRKI---LIITALFMGAVSFSIYFYVhqIWLFIV 105
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLplgPLLTGLGLSLLGFAPNYWL--LLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 106 LYALFQGLFAPAMPQLYASAresinassSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKgysGLFGGTIAIILFTLI 185
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQA--------AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALF---GGLGLLILLIIPGLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 186 LQVFFYKNLPVKNQISEQQhiEKIAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEK---ERYVGYLASLC 262
Cdd:cd17478 162 VALLLLRLRPLKKPEAKKA--AAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRgysLVFAGLLLSLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 263 AGLEVPFMVILGILSAKLPTRTLLIIgSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYFQDILPDFPGYA 342
Cdd:cd17478 240 LFAGAIGTLIGGPLSDRFGRRRVIIA-SLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLA 318
|
....
gi 394281562 343 STLF 346
Cdd:cd17478 319 SGLM 322
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
5-191 |
8.76e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.61 E-value: 8.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 5 LLQIKNYKLFVVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFsdTHHLNRKILIITAL 84
Cdd:cd17329 196 VLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARL--VERFRLRKILMIGI 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 85 FMGAVSFSIYFYVHQIWLFIVLYALF---QGLFAPAMPQLyasaresINASSSRDRAKFANTVLRSMFSLGFLFGPFIGA 161
Cdd:cd17329 274 LLFAIGFAVLAFANTLAVLILAMIVLtlgEMLVFPAVQTL-------VAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG 346
|
170 180 190
....*....|....*....|....*....|
gi 394281562 162 QLIELKGYSGLFGGTIAIILFTLILQVFFY 191
Cdd:cd17329 347 LLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
223-395 |
6.89e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 6.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 223 FIAFILLHIGQWMYTMNMPLFVTDYLNEKERYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGV 302
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 303 FKNFHMMLVGQICLAIFLAILLGLGISYFQDILPD-FPGYASTLFANAMVIGQLGGNLLGGVMSHWVGLENVFFVSASSI 381
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170
....*....|....
gi 394281562 382 FVGMILILFTKDQK 395
Cdd:pfam07690 162 LLAAVLLLLPRPPP 175
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
13-328 |
1.38e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.71 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 13 LFVVNMLLLGMGIAVT-VPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHLNRkiLIITALFMGAVSF 91
Cdd:COG2807 20 LLAIVLVALNLRPAITsVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLER--TLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 92 SIYFYVHQIWLFIVLYALF---QGLFAPAMPQLyasaresINASSSRDRAkFANTVLRSMFSLGFLFGPFIGAQLIELKG 168
Cdd:COG2807 98 LLRSLAPSVALLLAGTALIgagIAVGNVLLPGL-------IKRWFPDRVG-LMTGLYTAAMGLGAALAAGLTVPLAAALG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 169 YSGLFGGTIAIILFTLILQVFFYKNLPVKNQISEQqhiEKIAPNMFKDKsLFIPFIAFILLHIGQWmYTMN--MPLFVTD 246
Cdd:COG2807 170 WRGALAVWALLALLALLLWLPLLRRRPAAAAAAPA---AASLRSLWRSP-LAWLLTLFFGLQSLLY-YAVVawLPPILRD 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 247 yLNEKERYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAfyfsIGVFknfhMMLVGQICLAIFLAILLGL 326
Cdd:COG2807 245 -AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGL----AGLL----GLLLAPGSLPWLWAVLLGL 315
|
..
gi 394281562 327 GI 328
Cdd:COG2807 316 GQ 317
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
4-192 |
1.42e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 43.73 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 4 ALLQIKNYKLFVVNMLLLGMGIAVTVPYLILFaTKDLGMTTTQYGLLLALAAISQ----FIVNSIIARFSdthhlNRKIL 79
Cdd:cd17335 193 ALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWH-LQDLGGSKTLIGLLWTVGVVSEipffFFSSRLIQRFG-----HVGLL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 80 IItALFMGAVSFSIYFYVHQIWLFIVLyALFQGLFAPAMpqlYASARESINASSSRDRAKFANTVLRSM-FSLGFLFGPF 158
Cdd:cd17335 267 YL-GLLAYVVRWLLYSFLENPWLVLPI-ELLHGLTFALV---WAAAVSYASAAAPPGLRATAQGLLQGLyFGLGGGLGSL 341
|
170 180 190
....*....|....*....|....*....|....
gi 394281562 159 IGAQLIELKGYSGLFGGTIAIILFTLILQVFFYK 192
Cdd:cd17335 342 IGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
5-113 |
3.30e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.56 E-value: 3.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 5 LLQIKNYKLFVVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHLNRKILIITAL 84
Cdd:cd17503 174 LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL 253
|
90 100
....*....|....*....|....*....
gi 394281562 85 FMGAVSFSIYFYVHQIWLFIVLYALFQGL 113
Cdd:cd17503 254 LALGTLLLAFLTPDTSLWLIILPLFIRGL 282
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
31-186 |
4.23e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.17 E-value: 4.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 31 YLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHLNRKILIITALFMgAVSFSIYFYVHQIWLFI---VLY 107
Cdd:cd17474 220 YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLY-ALSLLLLGFVPSLALLLiaiVLF 298
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 394281562 108 ALFQGLFAPAMPQLyasareSINASSSRDRAkFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLFGGTIAIILFTLIL 186
Cdd:cd17474 299 GLGLGLNLPLLTTL------VTELAPEEERG-TASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
18-303 |
4.33e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 41.72 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 18 MLLLGMGIAVTVPYLILFAtKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHlNRKILIITALFMGAVSFSIYFyV 97
Cdd:COG0477 23 TFLEGLDFTIVNVALPSIA-ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYG-RKRVLLIGLLLFGLASLLCGL-A 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 98 HQIWLFIVLYALfQGLFAPAMpqlYASARESINASSSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLFGGTI 177
Cdd:COG0477 100 PSPELLIAARAL-QGIGAGGL---MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 178 AIILFTLILQVFFYKNLPVKNQISEQQHIEKIAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLnekeryVGY 257
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL------LLA 249
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 394281562 258 LASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVF 303
Cdd:COG0477 250 LLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| PRK11128 |
PRK11128 |
3-phenylpropionate MFS transporter; |
38-119 |
6.79e-04 |
|
3-phenylpropionate MFS transporter;
Pssm-ID: 236856 [Multi-domain] Cd Length: 382 Bit Score: 41.43 E-value: 6.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 38 KDLGMTTTQYGLLLALAAISQFIVNSIIA-RFSDTHHL---NRKILIITALFMGAVSFSiyfyVHQIWLFIVLYALFQGL 113
Cdd:PRK11128 32 KGQGYTPETIGLLLGAGLVARFLGSLLIApRVKDPSQLipaLRLLALLTLLFAVAFWFG----AHSFWLLFVAIGLFNLF 107
|
....*.
gi 394281562 114 FAPAMP 119
Cdd:PRK11128 108 FSPLVP 113
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
21-317 |
1.97e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 39.93 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 21 LGMGIAVTV-PYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDthHLNRKILIITALFMGAVSFSIYFYVHQ 99
Cdd:cd17388 13 MGIGLIMPVlPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSD--RFGRRPVLLLSLAGAALDYLLMAFAPT 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 100 IWLfivlyaLFQG-LFAPAMPQLYASARESI-NASSSRDRAKfANTVLRSMFSLGFLFGPFIGAQLIELKGYSG-LFGGT 176
Cdd:cd17388 91 LWW------LYLGrIIAGITGATGAVAAAYIaDVTPPEQRAR-NFGLLGAAFGLGFIAGPALGGLLGEISPRAPfLVAAG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 177 IAIILFTLILQVFFYKNLPVKNQISEQQHIEKIAP--NMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEKERY 254
Cdd:cd17388 164 LNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSlrWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTM 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 394281562 255 VGYLASLCAGLEVPFMVIL-GILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLA 317
Cdd:cd17388 244 VGLSLAVFGLLHALFQAFVtGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLA 307
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
210-391 |
2.30e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 210 APNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDyLNEKERYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIG 289
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 290 SVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYFQDILP-DFPGYASTLFANAMVIGQLGGNLLGGVMSHWV 368
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|...
gi 394281562 369 GLENVFFVSASSIFVGMILILFT 391
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
38-330 |
3.35e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.48 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 38 KDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHLNRKILIITALFMGAVSFSIYFyvHQIWLFIVLYALfQGLFAPA 117
Cdd:cd17504 24 REFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA--PNLPVLIAGRAL-QGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 118 MPQLYASARESInassSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLFGGTIAIILFTLILqvffyknlpvk 197
Cdd:cd17504 101 FPLAFALVREEF----PPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL----------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 198 nqiseqqhIEKIAPNMFKDKSLFIPFIAFILLHIGQWMytmnMPLFVTDYLNEKERYVGYLASLCAGL-EVPFMVIL--- 273
Cdd:cd17504 166 --------VPLIDLRLLRRRNVLLANITALLAGFGMFM----VFQLLPQLLQLPTPTGFGLGITEAGLlLLPGALVMlia 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 394281562 274 ----GILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVgqiclAIFLAILLGLGISY 330
Cdd:cd17504 234 gplaGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALV-----VALLLIGIGLGLAF 289
|
|
| ATG22 |
pfam11700 |
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ... |
1-112 |
7.43e-03 |
|
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.
Pssm-ID: 371676 Cd Length: 479 Bit Score: 38.40 E-value: 7.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 1 MFTALLQIKNYKLFVVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHLNRK--- 77
Cdd:pfam11700 275 TLKQARKLKDALLFLVAWFLLSDGIATVSSTAVLFAKTELGMSTSQLTLLNIVAMIAAVLGAFLWPFVSRRFNLKTKqtl 354
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 394281562 78 --ILIITAL-----FMGAVSFSIYF-YVHQIWLFIVLYALFQG 112
Cdd:pfam11700 355 iaCIVLFELiplygLLGIILGKIGLkNPWEFWVLQAFYGLVLG 397
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
13-328 |
9.06e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 37.94 E-value: 9.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 13 LFVVNMLLLGMGIA----VTVPYLILFATKDLGMTTTQYGLLLAL----AAISQFIVNSIIARFSdthhlNRKILIITAL 84
Cdd:cd17319 2 WRIIPLLFLAYVINyldrVNISVAAPTIMKDLGLSPTQYGLIASAfflgYALFQVPGGWLLDRFG-----ARKVLAVSML 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 85 FMGAVSFSIYFyVHQIWLFIVLYALFqGLF-APAMPqlyASARESINASSSRDRAkFANTVLRSMFSLGFLFGPFIGAQL 163
Cdd:cd17319 77 LWSLFTALTGF-ATSLTSLYVLRFLL-GVAeAGFFP---GAIKALAEWFPARERG-RATGLFNSGAPLGAAIGPPLSGWL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 164 IELKGYSGLFggtIAIILFTLILQVFFYKNLPvknqiseqqhiekiapnmfkdkSLFIPFIAFILLHIGQWMYTMNMPLF 243
Cdd:cd17319 151 LLLFGWRWAF---IIEGLLGLLLAVLWWFYLR----------------------QVWGLALGYFGINYALYGLLTWLPTY 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394281562 244 VTDYLNEKERYVGYLASLCAGLEVPFMVILGILSAKLPT---RTLLIIGSVFGGAFYFSIGVFKNfHMMLVGQICLAIFL 320
Cdd:cd17319 206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarRLVIIIGLLLAAVGLLLAYLTTS-PVVAVILLSLAGFG 284
|
....*...
gi 394281562 321 AILLGLGI 328
Cdd:cd17319 285 IGAASPVF 292
|
|
| |
