NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
The query sequence EKC31663.1 may be preliminary or obsolete. For more information, check Entrez.
Conserved domains on  [gi|405966368|gb|EKC31663.1|]
View 

Orexin receptor type 2 [Crassostrea gigas]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606955)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

 Zoom to residue level

show extra options Â»

Show site features     Horizontal zoom: Ã—

List of domain hits

Name Accession Description Interval E-value
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-348 8.26e-157

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


:

Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 442.98  E-value: 8.26e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15208    1 WVLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVK-RQYIDLLIFCGPQWS 208
Cdd:cd15208   81 TVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVPlANKTILLTVCDERWS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRP---MMDGNVNRAEEQLESRKKAAKMLITVV 285
Cdd:cd15208  161 DSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRKwnkPRKSAVAAEEKQLRSRRKTAKMLIVVV 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 286 IGFAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15208  241 IMFAICYLPVHLLNILRYVFGLFTVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
 
Name Accession Description Interval E-value
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-348 8.26e-157

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 442.98  E-value: 8.26e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15208    1 WVLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVK-RQYIDLLIFCGPQWS 208
Cdd:cd15208   81 TVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVPlANKTILLTVCDERWS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRP---MMDGNVNRAEEQLESRKKAAKMLITVV 285
Cdd:cd15208  161 DSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRKwnkPRKSAVAAEEKQLRSRRKTAKMLIVVV 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 286 IGFAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15208  241 IMFAICYLPVHLLNILRYVFGLFTVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
66-337 1.29e-56

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 185.58  E-value: 1.29e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368   66 GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQTTSVAVSVFTLSAIS 144
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  145 VERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADlTRFVKRQYIdllIFCGPQW-SDKTNQVVYQSVII 221
Cdd:pfam00001  81 IDRYLAIVHPLRYKRrrTPRRAKVLILVIWVLALLLSLPPLLFGW-TLTVPEGNV---TVCFIDFpEDLSKPVSYTLLIS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  222 VLMYLLPLVLMTVTYSMIAVVLWTGKIPGaiesanrpmmdgnvnRAEEQLESRKKAAKMLITVVIGFAVCYFPVHLFNIL 301
Cdd:pfam00001 157 VLGFLLPLLVILVCYTLIIRTLRKSASKQ---------------KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLL 221
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 405966368  302 RYADALRFVAPRMIQVLSMIsHWLPYLNSSINPIIY 337
Cdd:pfam00001 222 DSLALDCELSRLLDKALSVT-LWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
32-341 7.49e-22

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 95.23  E-value: 7.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  32 DEEYLDYLEDYVFpDDWEWGIIILYALTFIVGLSGNVLVCFaVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDV 111
Cdd:PHA03087  24 DEDYADCDLNIGY-DTNSTILIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDL-LFVMTLPFQIYYYI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 112 TETWYFGFAMCKIALFLQTTSVAVSVFTLSAISVERWYAICYPLrfKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRF 191
Cdd:PHA03087 101 LFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPV--KSNKINTVKYGYIVSLVIWIISIIETTPILFVYT 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 192 VKRQYiDLLIfCGPQWSDKTN--QVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPgaiesanrpmmdgnvnraee 269
Cdd:PHA03087 179 TKKDH-ETLI-CCMFYNNKTMnwKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKS-------------------- 236
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 270 qlESRKKAAKMLITVVIGFAVCYFPVHLFNILRYADALRFV----APRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:PHA03087 237 --KKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKsgckAVKYIQYALHVTEIISLSHCCINPLIYAFVS 310
 
Name Accession Description Interval E-value
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-348 8.26e-157

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 442.98  E-value: 8.26e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15208    1 WVLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVK-RQYIDLLIFCGPQWS 208
Cdd:cd15208   81 TVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVPlANKTILLTVCDERWS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRP---MMDGNVNRAEEQLESRKKAAKMLITVV 285
Cdd:cd15208  161 DSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRKwnkPRKSAVAAEEKQLRSRRKTAKMLIVVV 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 286 IGFAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15208  241 IMFAICYLPVHLLNILRYVFGLFTVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
52-348 1.81e-94

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 284.11  E-value: 1.81e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd14993    3 LIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFK--STKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLI-FCGPQWS 208
Cdd:cd14993   83 SVSASVLTLVAISIDRYLAICYPLKARrvSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPGTITIyICTEDWP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvNRAEEQLESRKKAAKMLITVVIGF 288
Cdd:cd14993  163 SPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANS-------TSSRRILRSKKKVARMLIVVVVLF 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 289 AVCYFPVHLFNI-LRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14993  236 ALSWLPYYVLSIlLDFGPLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
52-341 5.88e-70

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 220.62  E-value: 5.88e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIvadltrFVKRQYIDLLIFCGPQWSD 209
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRrfTRRRAKLLIALIWLLSLLLALPPLL------GWGVYDYGGYCCCCLCWPD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnRAEEQLESRKKAAKMLITVVIGFA 289
Cdd:cd00637  155 LTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNS--------SRRRRRRRERKVTKTLLIVVVVFL 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 405966368 290 VCYFPVHLFNILRYADALRFVAPRmiqVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd00637  227 LCWLPYFILLLLDVFGPDPSPLPR---ILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
52-341 4.31e-69

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 219.03  E-value: 4.31e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15207    3 FIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYiDLLIFCGPQWSDKT 211
Cdd:cd15207   83 SVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRG-QTVHICVEFWPSDE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESanrpmmdgNVNRAEEQLESRKKAAKMLITVVIGFAVC 291
Cdd:cd15207  162 YRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGSA--------SREAQAAVSKKKVRVIKMLIVVVVLFALS 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 292 YFPVHLFNILryADALRFVAPRMIQVLSM---ISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15207  234 WLPLHTVTML--DDFGNLSPNQREVLYVYiypIAHWLAYFNSCVNPIVYGYFN 284
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
52-341 2.24e-67

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 214.53  E-value: 2.24e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSD-VTETWYFGFAMCKIALFLQT 130
Cdd:cd15392    3 IILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALlILQYWPFGEFMCPVVNYLQA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQyiDLLIFCGPQWSDK 210
Cdd:cd15392   83 VSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSNAS--CGQYICTESWPSD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESanrpmmdgnvNRAEEQLESRKKAAKMLITVVIGFAV 290
Cdd:cd15392  161 TNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKRTPGEAEN----------NRDQRMAESKRKLVKMMITVVAIFAL 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 291 CYFPVHLFNILR--YADALRFvapRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15392  231 CWLPLNILNLVGdhDESIYSW---PYIPYLWLAAHWLAMSHCCYNPFIYCWMN 280
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
52-340 4.13e-66

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 211.31  E-value: 4.13e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15203    3 LILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQGV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSDKT 211
Cdd:cd15203   83 SIFVSTLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILPYCGYFCTESWPSSS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGkipgaieSANRPMMDGNVNRAEEQLESRK-KAAKMLITVVIGFAV 290
Cdd:cd15203  163 SRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKR-------VKKKRGKRTLSSRRRRSELRRKrRTNRLLIAMVVVFAV 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 405966368 291 CYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15203  236 CWLPLNLFNLLRDFEPLPQIDGRHFYLIFLICHLIAMSSACVNPLLYGWL 285
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
50-340 2.62e-60

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 196.35  E-value: 2.62e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15095    1 WLVPLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPeviVADLTRFVKRQYIDLLIFCGPQW 207
Cdd:cd15095   81 QVTVQATCLTLTALSVDRYYAIVHPIRSLRfrTPRVAVVVSACIWIVSFLLSIP---VAIYYRLEEGYWYGPQTYCREVW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRPmmdgnvnraEEQLESRKKAAKMLITVVIG 287
Cdd:cd15095  158 PSKAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEQLS---------ERALRQKRKVTRMVIVVVVL 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 288 FAVCYFPVHLFNILRYADaLRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15095  229 FAICWLPNHVLNLWQRFD-PNFPETYATYALKIAALCLSYANSAVNPFVYAFM 280
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
53-341 4.77e-60

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 195.59  E-value: 4.77e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15390    4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFvKRQYIDLLIFCGPQWSDKTN 212
Cdd:cd15390   84 VAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETY-YYYTGSERTVCFIAWPDGPN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QV---VYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGaiesanrpmmdGNVNRAEEQLESRKKAAKMLITVVIGFA 289
Cdd:cd15390  163 SLqdfVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIG-----------ENTPRQLESVRAKRKVVKMMIVVVVIFA 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 405966368 290 VCYFPVHLFNILRYADALRFVAPRMIQVLSMIsHWLPYLNSSINPIIYNFMS 341
Cdd:cd15390  232 ICWLPYHLYFILTYLYPDINSWKYIQQIYLAI-YWLAMSNSMYNPIIYCWMN 282
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
54-348 1.41e-58

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 191.85  E-value: 1.41e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15393    5 ILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSDKTNQ 213
Cdd:cd15393   85 NVSVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVALALRVEELTDKTNNGVKPFCLPVGPSDDWW 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 VVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESAnrpmmdgnvnRAEEQLESRKKAAKMLITVVIGFAVCYF 293
Cdd:cd15393  165 KIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNAQDV----------RDDEILKNKKKVIKMLIIVVALFALCWL 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 294 PVHLFNIlryadaLRFVAP-----RMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15393  235 PLQTYNL------LNEIKPeinkyKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
52-348 1.50e-58

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 191.95  E-value: 1.50e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15202    3 LIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDlLIFCGPQWSD-- 209
Cdd:cd15202   83 SVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIV-RSLCLEDWPEra 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESanrpmmdgnvNRAEEQLESRKKAAKMLITVVIGFA 289
Cdd:cd15202  162 DLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGDATT----------ERYFALRRKKKKVIKMLMVVVVLFA 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 290 VCYFPVHLFNILRYADAlrFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15202  232 LCWLPFNIYVLLLSSKP--DYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
51-341 3.92e-57

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 188.11  E-value: 3.92e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15391    2 HLINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVkrQYIDLLIFCGPQW-SD 209
Cdd:cd15391   82 VSVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYG--QYSEGRVLCGESWpGP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESAnrpmmdgnvnRAEEQLESRKKAAKMLITVVIGFA 289
Cdd:cd15391  160 DTSRSAYTVFVMLLTYIIPLLILTSTYGYVGFRLWNRTAPGNADKG----------RDDMQIKSKRKVIKMLVFVVLMFG 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 290 VCYFPVHLFNIL-RYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15391  230 ICWLPLHLFNLVqDFSTVFRNMPQHTTRLIYGACHWIAMSNSFVNPIIYLFMN 282
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
66-337 1.29e-56

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 185.58  E-value: 1.29e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368   66 GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQTTSVAVSVFTLSAIS 144
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  145 VERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADlTRFVKRQYIdllIFCGPQW-SDKTNQVVYQSVII 221
Cdd:pfam00001  81 IDRYLAIVHPLRYKRrrTPRRAKVLILVIWVLALLLSLPPLLFGW-TLTVPEGNV---TVCFIDFpEDLSKPVSYTLLIS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  222 VLMYLLPLVLMTVTYSMIAVVLWTGKIPGaiesanrpmmdgnvnRAEEQLESRKKAAKMLITVVIGFAVCYFPVHLFNIL 301
Cdd:pfam00001 157 VLGFLLPLLVILVCYTLIIRTLRKSASKQ---------------KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLL 221
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 405966368  302 RYADALRFVAPRMIQVLSMIsHWLPYLNSSINPIIY 337
Cdd:pfam00001 222 DSLALDCELSRLLDKALSVT-LWLAYVNSCLNPIIY 256
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
52-348 6.42e-56

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 184.40  E-value: 6.42e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15001    2 VIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIfCGPQWSD 209
Cdd:cd15001   82 SFICSVLTLTAISIERYYVILHPMKAKSfcTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYH-CQKAWPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSmiavvlwtgkipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIGFA 289
Cdd:cd15001  161 TLYSRLYVVYLAIVIFFIPLIVMTFAYA---------------------------------RDTRKQVIKMLISVVVLFA 207
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 290 VCYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15001  208 VCWGPLLIDNLLVSFDVISTLHTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
50-348 1.01e-55

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 184.80  E-value: 1.01e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLS-DVTETWYFGFAMCKIALFL 128
Cdd:cd14997    1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVEtWAREPWLLGEFMCKLVPFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 129 QTTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYiDLLIFCGPQ 206
Cdd:cd14997   81 ELTVAHASVLTILAISFERYYAICHPLQAKYvcTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDG-TPVAVCRTP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 wSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVL-WTgkipgaiesaNRPMMDGNVNRAEEQLESRKKAAKMLITVV 285
Cdd:cd14997  160 -ADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLvGH----------PALESRRADAANRHTLRSRRQVVYMLITVV 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 286 IGFAVCYFP---VHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14997  229 VLFFVCLLPfrvVTLWIIFAPDEDLQALGLEGYLNLLVFCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
53-348 2.71e-54

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 181.13  E-value: 2.71e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15205    4 VITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFK--STKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSDK 210
Cdd:cd15205   84 VVTSILTMTCIAVERHQGIVHPLKMKwqYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEVKYDFLYEKRHVCCLERWYSP 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANrpmmdgNVNRAEEQLESRKK--AAKMLITVVIGF 288
Cdd:cd15205  164 TQQKIYTTFILVILFLLPLTTMLFLYSRIGYELWIKKRVGDASVLQ------TIHGIEMSKISRKKkrAVKMMVTVVLLF 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 289 AVCYFPVHLFNILR-YADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15205  238 AVCWAPFHVVHMMIeYSNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
52-348 4.55e-54

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 180.32  E-value: 4.55e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd14992    3 LGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQyIDLLIFCGPQW-- 207
Cdd:cd14992   83 SVYASSLTLTAIAFDRYFAIIHPLKPRHrqSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVK-NQEKIFCCQIPpv 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESAnrpmmdgnvnRAEEQLESRKKAAKMLITVVIG 287
Cdd:cd14992  162 DNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSIKE----------VERKRLKCKRRVIKMLVCVVVL 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 288 FAVCYFPVHLFNILRYADALRFVAPRMIQVLSMIsHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14992  232 FVICWLPFHLFFLLRDFFPLIMKEKHTLQVYYFL-HWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
51-348 1.77e-52

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 175.06  E-value: 1.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPevivadltRFVKRQYIDLLIFCGPQWs 208
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQlmTKKRALIMIAAVWVYSLLISLP--------PLVGWRDETQPSVVDCEC- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnRAEeqlesrKKAAKMLITVVIGF 288
Cdd:cd14967  152 EFTPNKIYVLVSSVISFFIPLLIMIVLYARIFRVA----------------------RRE------LKAAKTLAIIVGAF 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPrmiqVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14967  204 LLCWLPFFIIYLVSAFCPPDCVPP----ILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
54-335 1.47e-51

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 173.99  E-value: 1.47e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15927    5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLR--FKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLI-FCGPQWSDK 210
Cdd:cd15927   85 GVSVFTLTALSADRYFAIVNPMRkhRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQIcYPYPQELGP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGkipgaiesaNRPMMDGNVNRAEEQLESRKKAAKMLITVVIGFAV 290
Cdd:cd15927  165 NYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIRS---------TRNIGSGQNQAAQRQIEARKKVAKTVLAFVVLFAV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 405966368 291 CYFPVHLFNILRYADALRFVAPRMI-QVLSMISHWLPYLNSSINPI 335
Cdd:cd15927  236 CWLPRHVFMLWFHFAPNGLVDYNAFwHVLKIVGFCLSFINSCVNPV 281
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
54-348 2.90e-50

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 170.17  E-value: 2.90e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLtrFVKRQYIDLLIFCGPQWSDKT 211
Cdd:cd15096   85 YASVYTLVLMSLDRYLAVVHPITSMSirTERNTLIAIVGIWIVILVANIPVLFLHGV--VSYGFSSEAYSYCTFLTEVGT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGaiesanrpmmdgnVNRAEEQLESRKKAAKMLITVVIGFAVC 291
Cdd:cd15096  163 AAQTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPG-------------GRRSAESQRGKRRVTRLVVVVVVVFAIC 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 292 YFPVHL-FNILRYADALRFVAPRMIQVLsmiSHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15096  230 WLPIHIiLLLKYYGVLPETVLYVVIQIL---SNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
52-337 2.21e-49

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 167.90  E-value: 2.21e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15389    3 LIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIfCGPQW---S 208
Cdd:cd15389   83 SVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSR-CLPSFpepS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLmYLLPLVLMTVTYSMIAVVLWTGKIPGAIesanrpmmdgNVNRAEEQLESRKKAAKMLITVVIGF 288
Cdd:cd15389  162 DLFWKYLDLATFILQ-YVLPLLIIGVAYTRVAKKLWLRNAIGDV----------TTEQYVAQRRKKKKTIKMLMLVVLLF 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 405966368 289 AVCYFPVHLFNILryadaLRFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15389  231 AICWLPLNCYHVL-----LSSHPIRSNSALFFAFHWLAMSSTCYNPFIY 274
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
50-348 1.44e-48

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 165.26  E-value: 1.44e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15206    1 ELIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDllifCGPQW 207
Cdd:cd15206   81 AVSVSVSTFTLVAISLERYFAICHPLKSRVwqTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGGHK----CREVW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiesanrpmmdgnvnraeeqlESRKKAAKMLITVVIG 287
Cdd:cd15206  157 PNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL---------------------------EAKKRVIRMLFVIVVE 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 288 FAVCYFPVHLFNILR---YADALRFVAPRMIQVLsmisHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15206  210 FFICWTPLYVINTWKafdPPSAARYVSSTTISLI----QLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
52-348 8.51e-48

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 163.74  E-value: 8.51e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNR--SMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15098    3 VPVVFGLIFCLGVLGNSLVITVLARVKpgKRRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPeviVADLTRFVKRQYIDLLIFCGPQW 207
Cdd:cd15098   83 TVSMLVSIFTLVAMSVDRYIAVVHSRTSSSlrTRRNALLGVLVIWVLSLAMASP---VAVHQDLVHHWTASNQTFCWENW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTgKIPGAIESANRpmmdgnvnraeeqleSRKKAAKMLITVVIG 287
Cdd:cd15098  160 PEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHK-KLKNMSKKSER---------------SKKKTAQTVLVVVVV 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 288 FAVCYFPVHLfnILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15098  224 FGISWLPHHI--IHLWVEFGDFPLTQASFVLRITAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
50-348 9.81e-48

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 163.41  E-value: 9.81e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd14971    1 WIVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQyidlLIFCGPQW 207
Cdd:cd14971   81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHirTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGN----RTVCSEAW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeeqlESRKKAAKMLITVVIG 287
Cdd:cd14971  157 PSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSR--------------RAKRKVTRLVLVVVVL 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 288 FAVCYFPVHLFNILRYADalRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14971  223 FAACWGPIHAILLLVALG--PFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
51-348 3.72e-47

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 162.52  E-value: 3.72e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPptllSDVTETWY-----FGFAMCKIA 125
Cdd:cd14979    2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLP----VELYNFWWqypwaFGDGGCKLY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 126 LFLQTTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPevivadLTRFVKRQYIDLLI-- 201
Cdd:cd14979   78 YFLFEACTYATVLTIVALSVERYVAICHPLKAKTlvTKRRVKRFILAIWLVSILCAIP------ILFLMGIQYLNGPLpg 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 202 ------FCGPQWSDKTNQVVYQSVIIVLmYLLPLVLMTVTYSMIAVVLWTGKIpgaIESANRPMMDGNVNRAEEQlESRK 275
Cdd:cd14979  152 pvpdsaVCTLVVDRSTFKYVFQVSTFIF-FVLPMFVISILYFRIGVKLRSMRN---IKKGTRAQGTRNVELSLSQ-QARR 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 276 KAAKMLITVVIGFAVCYFPVHLFNIL-RYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14979  227 QVVKMLGAVVIAFFVCWLPFHAQRLMfSYASKEDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
52-337 4.75e-47

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 161.83  E-value: 4.75e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTET-WYFGFAMCKIALFLQT 130
Cdd:cd15394    3 IIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRgWVFGRFMCYFVFLMQP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIvadltrfvKRQYIDL----LIFCGPQ 206
Cdd:cd15394   83 VTVYVSVFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALPAAA--------HTYYVEFkgldFSICEEF 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQ-VVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANrpmmdgnvnrAEEQLESRKKAAKMLITVV 285
Cdd:cd15394  155 WFGQEKQrLAYACSTLLITYVLPLLAISLSYLRISVKLRNRVVPGSMTQSQ----------AEWDRARRRKTFRLLVVVV 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 405966368 286 IGFAVCYFPVHLFNILRYADaLRFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15394  225 VAFAICWLPLHIFNVIRDID-IDLIDKQYFNLIQLLCHWLAMSSACYNPFLY 275
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
52-348 6.94e-46

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 159.03  E-value: 6.94e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTE-TWYFGFAMCKIALFLQT 130
Cdd:cd15134    3 ITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQyPWVFGEVFCKLRAFLSE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFK--STKRRAKIIILVIWIIAFLLALPeviVADLTRFVKRQY-------IDLLI 201
Cdd:cd15134   83 MSSYASVLTITAFSVERYLAICHPLRSHtmSKLSRAIRIIIAIWIIAFVCALP---FAIQTRIVYLEYpptsgeaLEESA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 202 FCGPQWSDKTNQVVYQsVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiESANRPMMDGNVNRAEEQLESRKKAAKML 281
Cdd:cd15134  160 FCAMLNEIPPITPVFQ-LSTFLFFIIPMIAIIVLYVLIGLQLR--------RSTLLRRGQRSVSGGRRSSQSRRTVLRML 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 282 ITVVIGFAVCYFPVHLFNILR-YADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15134  231 VAVVVAFFICWAPFHAQRLLTvYAKNMTPPYLFINRILFYISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
52-348 3.22e-45

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 157.29  E-value: 3.22e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15981    3 FILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDL------LIFCGP 205
Cdd:cd15981   83 SVSASVFTLVAIAVERFRCIVHPFRQKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEHHFMVDDynnsypLYSCWE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 QWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTgkipgaiesANRPMMDGNVNRAEEQLESRKKAA--KMLIT 283
Cdd:cd15981  163 AWPDTEMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFK---------SSAPIRGSQGEEEEGRRVSKRKIKviNMLII 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 284 VVIGFAVCYFPvhLFNILRYADALRFVAPRMIQVLSMI---SHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15981  234 VALFFTLSWLP--LWTLMLLTDYGHLSEDQLNLVTVYVfpfAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
53-348 8.02e-44

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 153.89  E-value: 8.02e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15980    4 IASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTrfvKRQYIDLLI----------F 202
Cdd:cd15980   84 VSASVFTLVAIAVDRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQ---EEKNYRVVLgsqnktspvyW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 203 CGPQWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPgaiesanrpmMDGNVNRAEEQLESRKKAA--KM 280
Cdd:cd15980  161 CREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMP----------HTGKHNQEQRHVVSRKKQKviKM 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 281 LITVVIGFAVCYFPVHLFNILR-YADalrfVAPRMIQVLSM----ISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15980  231 LLIVALLFILSWLPLWTLMMLSdYAN----LSPNQLQIINIyiypFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
56-348 1.62e-43

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 152.39  E-value: 1.62e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  56 YALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAV 135
Cdd:cd16003    7 YGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 136 SVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIvadltrFVKRQYIDLLIFCGPQWSDKTNQ-V 214
Cdd:cd16003   87 SIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCL------YSKTKVMPGRTLCFVAWPGGPDQhF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 215 VYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGaiesanrpmmdGNVNRAEEQLESRKKAAKMLITVVIGFAVCYFP 294
Cdd:cd16003  161 TYHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPG-----------DTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLP 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 405966368 295 VHLFNILRyADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd16003  230 YHIYFIVT-GLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
53-341 7.15e-43

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 150.99  E-value: 7.15e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd14986    4 VAVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVadltrFVKRQYIDLLIFCGPQWSDKTN 212
Cdd:cd14986   84 LFASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLVI-----FVERELGDGVHQCWSSFYTPWQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLW-TGKIPGAIESANRPMMDGNVNRAEEQLE----SRKKAAKMLITVVIG 287
Cdd:cd14986  159 RKVYITWLATYVFVIPLIILSYCYGRILRTIWiRSRQKTDRPIAPTAMSCRSVSCVSSRVSlisrAKIKTIKMTLVIILA 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 288 FAVCYFPVHLFNILR-YADA--LRFVAPRMIQVLSMishwlpyLNSSINPIIYNFMS 341
Cdd:cd14986  239 FILCWTPYFIVQLLDvYAGMqqLENDAYVVSETLAS-------LNSALNPLIYGFFS 288
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
54-337 4.97e-41

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 146.14  E-value: 4.97e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd16004    5 IAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRfvkRQYIDLLIFCGPQWSDKTNQ 213
Cdd:cd16004   85 FVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTM---DQGRTKCIVAWPGDSGGKHQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 VVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGaiesanrpmmDGNVNRAEEQLESRKKAAKMLITVVIGFAVCYF 293
Cdd:cd16004  162 LTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPG----------HQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWL 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 405966368 294 PVHLFNILRYADALRFVAPRMIQVLSMIsHWLPYLNSSINPIIY 337
Cdd:cd16004  232 PYHLYFILGSFNEDIYCQKYIQQVYLAI-FWLAMSSTMYNPIIY 274
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
52-348 1.70e-40

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 144.36  E-value: 1.70e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIcLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd14970    3 IPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLG-LPFLATSYLLGYWPFGEVMCKIVLSVDAY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLrfKSTKRR----AKIIILVIWIIAFLLALPEVIVADLtrfvkRQYIDLLIFCGPQW 207
Cdd:cd14970   82 NMFTSIFCLTVMSVDRYLAVVHPV--KSLRFRtprkAKLVSLCVWALSLVLGLPVIIFART-----LQEEGGTISCNLQW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVI--IVLMYLLPLVLMTVTYSMIAVVL-WTGKIPGAiesanrpmmdgnvnRAEEQLESRKKAAKMLITV 284
Cdd:cd14970  155 PDPPDYWGRVFTIytFVLGFAVPLLVITVCYSLIIRRLrSSRNLSTS--------------GAREKRRARRKVTRLVLVV 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 285 VIGFAVCYFPVHLFNILRYAdalrfVAPRMIQVLSMISHW---LPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14970  221 VAVFVVCWLPFHVFQIVRLL-----IDPPETLTVVGVFLFciaLSYANSCLNPILYAFLDENFRKSF 282
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
52-348 9.29e-40

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 142.95  E-value: 9.29e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd14977    3 IMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIW--IIAFLLALPEVIVADLTRfVKRQYIDLLIFCGPQWSD 209
Cdd:cd14977   83 SLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAViwVGSVLLAVPEAVLSTVAR-ESSLDNSSLTVCIMKPST 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVY--QSVIIVLMY-LLPLVLMTVTYSMIAVVLWTGKIPGAIesanrpmmdgnvnRAEEQLESRKKAAKMLITVVI 286
Cdd:cd14977  162 PFAETYPkaRSWWLFGCYfCLPLAFTAVCYLLMARTLIRAAKEYTR-------------GTKKHMKQRRQLAKTVLCLVL 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 287 GFAVCYFPVHLFNILR-YADALRFVAPRM-IQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14977  229 VFAFCWLPEHISNILRaTLYNEVLIDTRStLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
51-343 4.44e-39

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 141.02  E-value: 4.44e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALtFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15197    3 QLATLWVL-FVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVadltrFVKRQYIDLLIFCGPQWSDK 210
Cdd:cd15197   82 VVTYASTYVLVALSIDRYDAICHPMNFSQSGRQARVLICVAWILSALFSIPMLII-----FEKTGLSNGEVQCWILWPEP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWT-GKIPGAIESAN-------RPMMDGNVNRAeeqlesRKKAAKMLI 282
Cdd:cd15197  157 WYWKVYMTIVAFLVFFIPATIISICYIIIVRTIWKkSKIQVTINKAGlhdgssrRSSSRGIIPRA------KIKTIKMTF 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 283 TVVIGFAVCYFPVHLFNILRYADALRfvAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQ 343
Cdd:cd15197  231 VIVTVFIICWSPYFVFDLLDVFGLLP--RSKTKIAAATFIQSLAPLNSAINPLIYCLFSTH 289
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
52-341 9.57e-39

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 140.06  E-value: 9.57e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15123    3 IYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILV--IWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGP-QWS 208
Cdd:cd15123   83 SVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAgcVWIVSMLFAIPEAVFSDLYSFRDPEKNTTFEACAPyPVS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTgkipgaiESANRPMMDGnvNRAEEQLESRKKAAKMLITVVIGF 288
Cdd:cd15123  163 EKILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYK-------STFNMPAEEH--SHARKQIESRKRVAKTVLVLVALF 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPRMIQVLSMI-SHWLPYLNSSINPIIYNFMS 341
Cdd:cd15123  234 AFCWLPNHILYLYRSFTYHTSVDSSAFHLIATIfSRVLAFSNSCVNPFALYWLS 287
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
52-341 1.24e-38

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 139.50  E-value: 1.24e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15012    2 FIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSD 209
Cdd:cd15012   82 SYTASIGILVVISVERYIAILHPLRCKQllTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICVLDREM 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 kTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGkipgaieSANRPmmdgnvnraeeqlesRKKAAKMLITVVIGFA 289
Cdd:cd15012  162 -FNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKS-------SSIEA---------------RRKVVRLLVAVVVSFA 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 405966368 290 VCYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15012  219 LCNLPYHARKMWQYWSEPYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAFLS 270
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
53-348 1.30e-38

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 139.62  E-value: 1.30e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15978    4 ILLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYiDLLIFCGPQWSDK 210
Cdd:cd15978   84 VSVSTFNLVAISLERYSAICKPLksRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINN-STGNMCRLLWPND 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgnvnraeEQLESRKKAAKMLITVVIGFAV 290
Cdd:cd15978  163 VTQQSWYIFLLLILFLIPGIVMMTAYGLISLELYRGI---------------------KFLMAKKRVIRMLIVIVILFFL 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 291 CYFPVHLFNILRYADalRFVAPRMIQ--VLSMIsHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15978  222 CWTPIFSANAWRAFD--TRSADRLLSgaPISFI-HLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
53-348 1.25e-37

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 136.87  E-value: 1.25e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15979    4 ILLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPeVIVADLTRFVKRQYIDLLIFCGPQWSDK 210
Cdd:cd15979   84 VSVSTFSLVAIAIERYSAICNPLqsRVWQTRSHAYRVIAATWLLSGLIMIP-YPVYSVTVPVPVGDRPRGHQCRHAWPSA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGkipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIGFAV 290
Cdd:cd15979  163 QVRQAWYVLLLLILFFIPGVVMIVAYGLISRELYRG------------------------LLAKKRVIRMLVVIVAMFFL 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 291 CYFPVHLFNILRYADALRFVAPRMIQVLSMIsHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15979  219 CWLPIFSANTWRAFDPLSAHRALSGAPISFI-HLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
50-348 2.43e-36

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 133.87  E-value: 2.43e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15124    1 YAIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIW--IIAFLLALPEVIVADLTRFVKRQYIDLLIFCGP-Q 206
Cdd:cd15124   81 LTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALiwILSMLLAIPEAVFSDLHPFYDKSTNKTFVSCAPyP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaIESANRPMMDGNVNrAEEQLESRKKAAKMLITVVI 286
Cdd:cd15124  161 HSNELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNL--------IRSAYNLPVEGNVH-VRRQIESRKRLAKTVLVFVG 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 287 GFAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15124  232 LFAFCWLPNHIIYLYRSYHYSEVDTSMLHFVSSICARILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
52-340 1.18e-35

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 131.78  E-value: 1.18e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15397    3 LVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQ-------YIDLLIfCG 204
Cdd:cd15397   83 SVTVSILSLVLIALERHQLIINPTGWKPSVSQAYLAVVVIWMLACFISLPFLAFHILTDEPYKNlshffapLADKAV-CT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 PQWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaieSANRPMMD--GNVNRaeeQLESRKKAAKMLI 282
Cdd:cd15397  162 ESWPSEHHKLAYTTWLLLFQYCLPLLFILVCYLRIYLRL----------RRRKDMLErrGEYNR---RAGHSKRINVMLV 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 283 TVVIGFAVCYFPVHLFNILRYADaLRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15397  229 SLVAAFALCWLPLNVFNAIADWN-HEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFL 285
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
51-347 2.21e-35

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 131.16  E-value: 2.21e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQ 129
Cdd:cd15131    2 GITVTCVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDL-LIFLCMPLDLYRLWQyRPWNFGDLLCKLFQFVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQW 207
Cdd:cd15131   81 ESCTYSTILNITALSVERYFAICFPLRAKVvvTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKATEY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeeQLESRKKAAKMLITVVIG 287
Cdd:cd15131  161 AVRSGLLTIMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRRENIGPNASH------------RDKNNRQTVKMLAVVVFA 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 288 FAVCYFPVHLFNIL--RYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGA 347
Cdd:cd15131  229 FVLCWLPFHVGRYLfsKSFEAGSLEIALISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVA 290
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
52-341 2.66e-35

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 131.11  E-value: 2.66e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15396    3 LIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLT-----------RFVKRQYIdll 200
Cdd:cd15396   83 SVSVSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIFHQLTdepfrnlsshsDFYKDKVV--- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 201 ifCGPQWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesANRPMMDGNVNRAEEQLESRKKAAKM 280
Cdd:cd15396  160 --CIEAWPSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCL-----------KKRNSKIDRMRENESRLSENKRINTM 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 281 LITVVIGFAVCYFPVHLFNIL--RYADALRFVAPRMIQVLsmiSHWLPYLNSSINPIIYNFMS 341
Cdd:cd15396  227 LISIVVTFAACWLPLNIFNVVfdWNHEVLMSCHHNLVFTL---CHLVAMVSTCINPIFYGFLN 286
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
51-348 3.96e-35

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 130.40  E-value: 3.96e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd14969    2 VLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLR-FKSTKRRAKIIILVIWIIAFLLALPEVI-------VADLTRfvkrqyidllif 202
Cdd:cd14969   82 FLGLVSISTLAALAFERYLVIVRPLKaFRLSKRRALILIAFIWLYGLFWALPPLFgwssyvpEGGGTS------------ 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 203 CGPQWSDKTnqVVYQSVIIVLM---YLLPLVLMTVTYSMIAVVLWtgkipgaiESANRPMMDGNVNRAEEQLESRKKAAK 279
Cdd:cd14969  150 CSVDWYSKD--PNSLSYIVSLFvfcFFLPLAIIIFCYYKIYRTLR--------KMSKRAARRKNSAITKRTKKAEKKVAK 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 280 MLITVVIGFAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHwlpylNSSI-NPIIYNFMSVQTKGAF 348
Cdd:cd14969  220 MVLVMIVAFLIAWTPYAVVSLYVSFGGESTIPPLLATIPALFAK-----SSTIyNPIIYVFMNKQFRRAL 284
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
51-341 7.78e-35

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 129.53  E-value: 7.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSD-VTETWYFGFAMCKIALFLQ 129
Cdd:cd15928    2 AVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLwRYRPWRFGDLLCRLMYFFS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDllifcGPQW 207
Cdd:cd15928   81 ETCTYASILHITALSVERYLAICHPLRAKVlvTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPR-----GFEC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVL---MYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeeQLESRKKAAKMLITV 284
Cdd:cd15928  156 TVVNVSSGLLSVMLWVstsFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASR------------RDNNHRQTVRMLAVI 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 285 VIGFAVCYFPVHL-----FNILRYADALRFVAprmiQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15928  224 VLAFVLCWLPFHVgrvifNHSRASTKHLHYVS----QYFNLVSFVLFYLSAAINPILYNLMS 281
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
54-340 7.80e-35

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 129.70  E-value: 7.80e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDV--TETWYFGFAMCKIALFLQTT 131
Cdd:cd15204    5 VVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVvrQRSWTHGDVLCAVVNYLRTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYidllIFCGPQWSDKt 211
Cdd:cd15204   85 SLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYANQGK----IFCGQIWPVD- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQS---VIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeEQLESRKKAAKMLITVVIGF 288
Cdd:cd15204  160 QQAYYKAyylFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIR-----------RRLRRRRRKVRLLVVILTAF 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 289 AVCYFPVHLFNILR-------YADALRFVAPRMIQVLSMIshwlpylNSSINPIIYNFM 340
Cdd:cd15204  229 VLCWAPYYGYAIVRdffptllSKEKLNTTIFYIVEALAMS-------NSMINTVVYVAF 280
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
52-348 8.10e-35

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 129.55  E-value: 8.10e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15399    3 LILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQAL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIfCGPQWSDKT 211
Cdd:cd15399   83 AVHVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFREYSVIEISPDFKIQA-CSEKWPNGT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQ--VVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAiesanrpmmdGNvnraEEQLESRKKAAKMLITVVIGFA 289
Cdd:cd15399  162 LNdgTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGG----------GN----DHYHQRRRKTTKMLVCVVVVFA 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 290 VCYFPVHLFNILRYADaLRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15399  228 VSWLPFHAFQLASDID-SKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
54-337 1.83e-34

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 128.44  E-value: 1.83e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd16002    5 VAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRqyidllIFCGPQWSDKTNQ 213
Cdd:cd16002   85 FASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGR------VVCYVEWPEHEER 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 V---VYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGaiesanrpmmdGNVNRAEEQLESRKKAAKMLITVVIGFAV 290
Cdd:cd16002  159 KyetVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPG-----------DSSDRYHEQVSAKRKVVKMMIVVVCTFAI 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 405966368 291 CYFPVHLFNILRYADALRFVApRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd16002  228 CWLPYHIYFLLQYFHPELYEQ-KFIQQVYLAIMWLAMSSTMYNPIIY 273
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
53-348 2.34e-34

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 127.89  E-value: 2.34e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSD--VTETWYFGFAMCKIALFLQT 130
Cdd:cd14995    4 TFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESllGPDSWIYGYAGCLLITYLQY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLR--FKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQyiDLLIFCGPQWS 208
Cdd:cd14995   84 LGINASSLSITAFTIERYIAICHPMKaqFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHYGD--DIVVRCGYKVS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQsVIIVLMYLLPLVLMTVTYSMIAVVLWTgkipgaiesanrpmmdgnvnraeeqleSRKKAAKMLITVVIGF 288
Cdd:cd14995  162 RHYYLPIYL-ADFVLFYVIPLLLAIVLYGLIGRILFS---------------------------SRKQVTKMLAVVVVLF 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPRMIqvlsMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14995  214 ALLWMPYRTLVVYNSFASPPYLDLWFL----LFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
53-348 9.62e-34

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 126.77  E-value: 9.62e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15000    3 SSMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIvadLTRFVKRQYIDLL-IFCGpqwSDKT 211
Cdd:cd15000   83 LLASVLALCAVSYDRLTAIVLPSEARLTKRGAKIVIVITWIVGLLLALPLAI---YRSYRERQWKNFLeTYCA---ENTQ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtGKIPGAIESANRPMmdgnvnraeeQLESRKKAAKMLITVVIGFAVC 291
Cdd:cd15000  157 VLPIYWHVIITVLVWLPLGIMLICYSAIFWKL--DKYERRVLRREHPS----------VVRYKKKAAKTLFIVLITFVVC 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 292 YFPVHLFNILRYADALRFVAPRMI----QVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15000  225 RIPFTALIFYRYKLVPNDNTQNSVsgsfHILWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
56-341 2.17e-33

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 126.08  E-value: 2.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  56 YALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAV 135
Cdd:cd15395    7 YSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 136 SVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLT-------RFVKRQYIDLLIfCGPQWS 208
Cdd:cd15395   87 SIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPFLIFQVLTdepfknvNVSLDAYKGKYV-CLDQFP 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaieSANRPMMD---GNVNRAEEQlesrKKAAKMLITVV 285
Cdd:cd15395  166 SDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRL----------KRRNNMMDkmrDNKYRSSET----KRINIMLISIV 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 286 IGFAVCYFPVHLFNILrYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15395  232 VAFAVCWLPLNIFNAV-FDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLN 286
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
52-341 2.95e-33

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 125.45  E-value: 2.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15125    3 IPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKR--RAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSD 209
Cdd:cd15125   83 SVGVSVFTLTALSADRYKAIVNPMDIQTSSAvlRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACIPYPQTD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaIESANRpMMDGNVNRAEEQLESRKKAAKMLITVVIGFA 289
Cdd:cd15125  163 EMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTL--------IKSAHN-IPGEYSEHSKRQMETRKRLAKIVLVFVGLFA 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 405966368 290 VCYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15125  234 FCWFPNHVLYMYRSFNYNEIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLS 285
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
54-348 4.71e-33

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 124.55  E-value: 4.71e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSM-RTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15097    5 VVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKrqyidlLIFCGPQWSDK 210
Cdd:cd15097   85 MYASSFTLAAVSVDRYLAIRYPLRSRElrTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYAN------STVCMPGWEEA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVlMYLLPLVLMTVTYSMIAVVLWTGKIPgaiesanrpmmdgnVNRAEEQLESRKKAAKMLITVVIGFAV 290
Cdd:cd15097  159 RRKAMDTCTFAF-GYLIPVLVVSLSYTRTIKYLWTAVDP--------------LEAMSESKRAKRKVTKMIIIVTALFCL 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 291 CYFPVHLFnILRYADAlRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15097  224 CWLPHHVV-ILCYLYG-DFPFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
53-348 8.02e-33

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 123.50  E-value: 8.02e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15196    4 IAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLR-FKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFcGPQWSDKT 211
Cdd:cd15196   84 MYASSYVLVATAIDRYIAICHPLSsHRWTSRRVHLMVAIAWVLSLLLSIPQLFIFSYQEVGSGVYDCWATF-EPPWGLRA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 nqvvYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIpgaiesanrpmmdgnvnraeeqlesrkKAAKMLITVVIGFAVC 291
Cdd:cd15196  163 ----YITWFTVAVFVVPLIILAFCYGRICYVVWRAKI---------------------------KTVKLTLVVVACYIVC 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 292 YFPVHLFNILRYADAlrfVAPRMIQVLSMIShWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15196  212 WTPFFVVQMWAAWDP---TAPIEGPAFVIIM-LLASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
54-348 2.32e-32

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 122.97  E-value: 2.32e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15094    5 VLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADE-CFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLifcGPQWSDKT 211
Cdd:cd15094   84 FTSSFTLTVMSADRYLAVCHPIRSMRyrTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIV---WPDSSAVN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTgkipgaiesanrpmmDGNVNRAEEQLESRKKAAKMLITVVIGFAVC 291
Cdd:cd15094  161 GQKAFTLYTFLLGFAIPLLLISVFYTLVILRLRT---------------VGPKNKSKEKRRSHRKVTRLVLTVISVYIIC 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 292 YFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15094  226 WLPYWAFQVHLIFLPPGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
54-341 2.83e-32

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 122.76  E-value: 2.83e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIiCLPPTLLSDVT-ETWYFGFAMCKIALFLQTTS 132
Cdd:cd14982    5 IVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVL-TLPFRIYYYLNgGWWPFGDFLCRLTGLLFYIN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIdllifCGPQWSD- 209
Cdd:cd14982   84 MYGSILFLTCISVDRYLAVVHPLKSRRlrRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTT-----CFEFLSEw 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanRPMMDGNVNRAEeqlesRKKAAKMLITVVIGFA 289
Cdd:cd14982  159 LASAAPIVLIALVVGFLIPLLIILVCYSLIIRAL-------------RRRSKQSQKSVR-----KRKALRMILIVLAVFL 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 290 VCYFPVHLFNILRYADALRFV----APRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd14982  221 VCFLPYHVTRILYLLVRLSFIadcsARNSLYKAYRITLCLASLNSCLDPLIYYFLS 276
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
52-348 4.41e-32

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 122.06  E-value: 4.41e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15051    3 LGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSd 209
Cdd:cd15051   83 LCTASILNLFAISLDRYLAITAPLRYPSrvTPRRVAIALAAIWVVSLAVSFLPIHLGWNTPDGRVQNGDTPNQCRFELN- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 ktnqVVYQSVIIVLMYLLPLVLMTVTYSMIAVVlwtgkipgAIESANR----PMMDGNVNRAEEQLESRKKAAKMLITVV 285
Cdd:cd15051  162 ----PPYVLLVAIGTFYLPLLIMCGVYLRIFRI--------AREQAKRinalTPASTANSSKSAATAREHKATVTLAAVL 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 286 IGFAVCYFPVHLFNILRyadalRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15051  230 GAFIICWFPYFTYFTYR-----GLCGDNINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
52-348 6.10e-31

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 119.56  E-value: 6.10e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPptllSDVTETWY-----FGFAMCKIAL 126
Cdd:cd15133    3 VCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMP----LELYELWQnypflLGSGGCYFKT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPLRFK--STKRRAKIIILVIWIIAFLLALPEVIVADLtrFVKRQYIDLLIFC- 203
Cdd:cd15133   79 FLFETVCLASILNVTALSVERYIAVVHPLAARtcSTRPRVTRVLGCVWGVSMLCALPNTSLHGI--KFLGSGVPASAQCt 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 --GPQWSdkTNQVVyqSVIIVLMYLLPLVLMTVTYSMIAvvLWTGKIPGAIESANRPMMDGNVNRAEEQLESRKKAAKML 281
Cdd:cd15133  157 vrKPQAI--YNMIP--QHTGHLFFVLPMAVISVLYLLMA--LRLARERGLDATGAGSKIGTRTGQLLQHPRTRAQVTKML 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 282 ITVVIGFAVCYFPVHLFNIL-----RYADALRFVaprmIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15133  231 FILVVVFAICWAPFHIDRLMwsfisDWTDNLHEV----FQYVHIISGVFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
52-348 3.87e-30

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 117.56  E-value: 3.87e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLsdvtETWY-----FGFAMCKIAL 126
Cdd:cd15358    3 VCVTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELY----EMWSnypflLGAGGCYFKT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRfvkrqyidLLIFC- 203
Cdd:cd15358   79 LLFETVCFASILNVTALSVERYIAVVHPLKAKYvvTRTHAKRVIGAVWVVSILCSIPNTSLHGIFQ--------LTVPCr 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 GPQWSDKTNQVV-----YQSVIIV---LMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRPMMDGNVN-RAEEQLESR 274
Cdd:cd15358  151 GPVPDSATCMLVkprwmYNLIIQIttlLFFFLPMGTISVLYLLIGLQLKREKMLLVLEAKGSKAGDSYQHrRIQQEKRRR 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 275 KKAAKMLITVVIGFAVCYFPVHLFNIL-RYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15358  231 RQVTKMLFVLVVVFGICWAPFHTDRLMwSFISQWTGELHLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFREMF 305
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
52-348 5.27e-30

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 116.41  E-value: 5.27e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15093    3 IPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIAD-ELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDGI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLrfKSTKRR----AKIIILVIWIIAFLLALPEVIVADLtrfvkRQYIDLLIFCGPQW 207
Cdd:cd15093   82 NMFTSIFCLTVMSVDRYLAVVHPI--KSARWRrprvAKVVNLAVWVASLLVILPVVVFAGT-----RENQDGSSACNMQW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTN--QVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeeqleSRKKAAKMLITVV 285
Cdd:cd15093  155 PEPAAawSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKR---------------SERKVTRMVVMVV 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 286 IGFAVCYFPVHLFNILRYadalrFVAPRMIQVLSMISHW---LPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15093  220 VVFVICWLPFYVLQLVNV-----FVQLPETPALVGVYHFvviLSYANSCANPILYGFLSDNFKKSF 280
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
54-348 6.84e-30

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 116.50  E-value: 6.84e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPptllSDVTETW-----YFGFAMCKIALFL 128
Cdd:cd15357    5 LVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMP----LEVYEMWsnypfLFGPVGCYFKTAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 129 QTTSVAVSVFTLSAISVERWYAICYPLRFK--STKRRAKIIILVIWIIAFLLALPEVIvadlTRFVKRQYI--------- 197
Cdd:cd15357   81 FETVCFASILSVTTVSVERYVAILHPFRAKlnSTRERALKIIVVLWVLSVLFSIPNTS----IHGIKLQYFpngtlipds 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 198 DLLIFCGPQWsdktnqvVYQSVIIV---LMYLLPLVLMTVTYSMIAVVLWTGKipgaieSANRPMMDGNVNRAeeqleSR 274
Cdd:cd15357  157 ATCTVVKPLW-------IYNLIIQItslLFYVLPMGVISVLYYLMGLKLRGDK------SLEADEMNVNIQRP-----SR 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 275 KKAAKMLITVVIGFAVCYFPVHLfNILRYADALRFVAP--RMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15357  219 KSVTKMLFVLVLVFAICWAPFHV-DRLFFSFVVEWTEPlaNVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
52-341 8.24e-30

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 116.00  E-value: 8.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVlVCFaVWRNRSMRTVTN--IFIVNLAIADLaVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd14999    2 IGTVLSLMCVVGVAGNV-YTL-VVMCLSMRPRASmyVYILNLALADL-LYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLR-FKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRfVKRQYIDLLIFCGPQWS 208
Cdd:cd14999   79 FLTMHASIFTLTVMSTERYLAVVKPLDtVKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVT-VEDKSGGSKRICLPTWS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 dKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeeqlESRKKAAKMLITVVIGF 288
Cdd:cd14999  158 -EESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKR--------------LPKQKVLKMIFTIVLVF 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd14999  223 WACFLPFWIWQLLYLYSPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLT 275
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
52-348 1.08e-29

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 115.82  E-value: 1.08e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15089    3 ITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLR---FKsTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWS 208
Cdd:cd15089   82 NMFTSIFTLTMMSVDRYIAVCHPVKaldFR-TPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGAVVCMLQFPSPSWY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTnqvVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgNVNRAEEQLESRKKAAKMLITVVIGF 288
Cdd:cd15089  161 WDT---VTKICVFIFAFVVPILVITVCYGLMILRLRSVR---------------LLSGSKEKDRNLRRITRMVLVVVAAF 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHwLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15089  223 IICWTPIHIFVIVWTLVDIDRRNPLVVAALHLCIA-LGYANSSLNPVLYAFLDENFKRCF 281
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
53-348 4.43e-29

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 114.32  E-value: 4.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGL---SGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15048    1 IVLAVLISVLILvtvIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLlifCGPQW 207
Cdd:cd15048   81 YTLCTASALTIVLISLDRYLSVTKAVKYRAkqTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGYSIVPTGD---CEVEF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDktnQVVYQSVIIVLMYLLPLVLMTVTYSMI--AVVLWTGKIPGA---IESANRPMMDGNVNRAEEQLESRKKAAKMLI 282
Cdd:cd15048  158 FD---HFYFTFITSVLEFFIPFISVSFFNLLIylNIRKRSRRRPLRsvpILPASQNPSRARSQREQVKLRRDRKAAKSLA 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 283 TVVIGFAVCYFPVHLFNILRYADALRFVAprmiQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15048  235 ILVLVFLICWAPYTILTIIRSFCSGSCVD----SYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
50-342 1.26e-28

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 112.69  E-value: 1.26e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLavIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd14984    1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADL--LFVLTLPFWAVYAADGWVFGSFLCKLVSALY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRqYIDLLIFcgPQW 207
Cdd:cd14984   79 TINFYSGILFLACISIDRYLAIVHAVSAlrARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGS-SICSYDY--PED 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnrAEEQLESRKKAAKMLITVVIG 287
Cdd:cd14984  156 TATTWKTLLRLLQNILGFLLPLLVMLFCYSRIIRTL-----------------------LRARNHKKHRALRVIFAVVVV 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 288 FAVCYFPVHLFNILRYADALRFVAP-----RMIQVLSMISHWLPYLNSSINPIIYNFMSV 342
Cdd:cd14984  213 FFLCWLPYNIVLLLDTLQLLGIISRscelsKSLDYALQVTESLAFSHCCLNPVLYAFVGV 272
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
52-348 1.65e-28

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 112.40  E-value: 1.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15090    3 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLR---FKsTKRRAKIIILVIWIIAFLLALPEVIVADLTRfvKRQYID-LLIFCGPQW 207
Cdd:cd15090   82 NMFTSIFTLCTMSVDRYIAVCHPVKaldFR-TPRNAKIVNVCNWILSSAIGLPVMFMATTKY--RQGSIDcTLTFSHPSW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTnqvVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgNVNRAEEQLESRKKAAKMLITVVIG 287
Cdd:cd15090  159 YWEN---LLKICVFIFAFIMPVLIITVCYGLMILRLKSVR---------------MLSGSKEKDRNLRRITRMVLVVVAV 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 288 FAVCYFPVHLFNILRyadALRFVAPRMIQVLSM-ISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15090  221 FIVCWTPIHIYVIIK---ALVTIPETTFQTVSWhFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
53-339 1.83e-28

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 112.35  E-value: 1.83e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFG---FAMCKIALFLQ 129
Cdd:cd14968    4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNFHgclFMACLVLVLTQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 ttsvaVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQW 207
Cdd:cd14968   84 -----SSIFSLLAIAIDRYLAIKIPLRYKSlvTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLESGCGEGGIQCLFEE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYqsVIIVLMYLLPLVLMTVTYSMIAVVlwtgkipgAIESANRPMMDGNVNRAEEQLESRKKAAKMLITVVIG 287
Cdd:cd14968  159 VIPMDYMVY--FNFFACVLVPLLIMLVIYLRIFRV--------IRKQLRQIESLLRSRRSRSTLQKEVKAAKSLAIILFL 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 405966368 288 FAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHwlpyLNSSINPIIYNF 339
Cdd:cd14968  229 FALCWLPLHIINCITLFCPECKVPKILTYIAILLSH----ANSAVNPIVYAY 276
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
53-351 6.63e-28

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 110.99  E-value: 6.63e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15384    4 IVVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRfvkRQYIDLLIFCGPQ--WSDK 210
Cdd:cd15384   84 LYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVER---GPFVEDFHQCVTYgfYTAE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVL---WTGKIPGAIESANRpmmdgNVNRAEEQLESRKKAAKMLITVVIG 287
Cdd:cd15384  161 WQEQLYNMLSLVFMFPIPLVIMVTCYVLIFITLsksSRDFQGLEIYTRNR-----GPNRQRLFHKAKVKSLRMSAVIVTA 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 288 FAVCYFPVHLFNILRyadaLRFVAPRMIQVLSMISHWLPYLNSSINPIIYnfmsvqtkGAFHLT 351
Cdd:cd15384  236 FILCWTPYYVIMIWF----LFFNPYPLNDILFDVIFFFGMSNSCVNPLIY--------GAFHIT 287
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
54-348 1.63e-27

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 109.71  E-value: 1.63e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIiCLPPTLLSDVTET-WYFGFAMCKIALFLQTTS 132
Cdd:cd15168    5 IVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLL-SLPFLIYYYANGDhWIFGDFMCKLVRFLFYFN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLR--FKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRqyidllIFCGPQWSDK 210
Cdd:cd15168   84 LYGSILFLTCISVHRYLGICHPLRslGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNR------TTCYDTTSPE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 --TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESAnrpmmdgnvnraeeqlesRKKAAKMLITVVIGF 288
Cdd:cd15168  158 elNDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVTSAL------------------RRKSIRLVIIVLALF 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAP-----RMIQVLSMISHWLPYLNSSINPIIYnFMSVQTKGAF 348
Cdd:cd15168  220 AVCFLPFHVTRTINLAARLLSGTAscatlNGIYVAYKVTRPLASLNSCLNPLLY-FLAGDKFRRR 283
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
55-341 1.78e-27

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 109.46  E-value: 1.78e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLP---PTLLSDvtETWYFGFAMCKIALFLQTT 131
Cdd:cd15088    6 VFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADL-LFMLGMPfliHQFAID--GQWYFGEVMCKIITALDAN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRfkSTKRR----AKIIILVIWIIAFLLALPEVIVADLTrfvkrQYIDLLIFCGPQW 207
Cdd:cd15088   83 NQFTSTYILTAMSVDRYLAVVHPIR--STKYRtrfvAKLVNVGLWAASFLSILPVWVYSSLI-----YFPDGTTFCYVSL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPgaiesanrpmmdGNVNRAEEQLesrKKAAKMLITVVIG 287
Cdd:cd15088  156 PSPDDLYWFTIYHFILGFAVPLVVITVCYILILHRLARGVAP------------GNQSHGSSRT---KRVTKMVILIVVV 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 288 FAVCYFPVH---LFNILRYADALRFVaprmiqVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15088  221 FIVCWLPFHvvqLVNLAMNRPTLAFE------VAYFLSICLGYANSCLNPFVYILVS 271
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
52-347 2.51e-27

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 109.71  E-value: 2.51e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTV-TNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15382    3 SIIVYSVLFLIAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVadltrFVKRQY--IDLLIFCGPQWS 208
Cdd:cd15382   83 FGLYLSSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPQSFI-----FHVESHpcVTWFSQCVTFNF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVV--YQSVIIVLMYLLPLVLMTVTYSMIavvLW----------TGKIPGAIESANRPMMDGNVNRAeeqlesRKK 276
Cdd:cd15382  158 FPSHDHElaYNIFNMITMYALPLIIIVFCYSLI---LCeisrkskekkEDVSEKSSSVRLRRSSVGLLERA------RSR 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 277 AAKMLITVVIGFAVCYFPVHLFNILRYADalRFVA---PRMIQVLSMIshwLPYLNSSINPIIYNFMSVQTKGA 347
Cdd:cd15382  229 TLKMTIVIVLVFIICWTPYFIMSLWYWFD--RESAskvDPRIQKGLFL---FAVSNSCMNPIVYGYFSIDLRRE 297
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
52-348 4.46e-27

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 108.40  E-value: 4.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15973    3 IQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIAD-ELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDGI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRR--AKIIILVIWIIAFLLALPEVIVADlTRFVKRQyidlLIFCGPQWSD 209
Cdd:cd15973   82 NMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPtvAKMINICVWILSLLVISPIIIFAD-TATRKGQ----AVACNLIWPH 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIavvlwTGKIPGAIESANrpmmdgnvnrAEEQLESRKKAAKMLITVVIGFA 289
Cdd:cd15973  157 PAWSAAFVIYTFLLGFLLPVLAIGLCYILI-----IGKMRAVALKAG----------WQQRRKSEKKITRMVLMVVTVFV 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 290 VCYFPVHLFNIlryadaLRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15973  222 ICWMPFYVVQL------LNLFLPRLDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
51-348 6.08e-27

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 107.81  E-value: 6.08e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVglSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15059    4 SSIVSVVILLII--VGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIvadlTRFVKRQYIDLLIFCGpqWS 208
Cdd:cd15059   82 LFCTASIVNLCAISLDRYWSVTQAVEYnlKRTPRRAKAMIAAVWIISAVISLPPLF----GWKDEQPWHGAEPQCE--LS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSviiVLMYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIG- 287
Cdd:cd15059  156 DDPGYVLFSS---IGSFYIPLLIMIIVYARIYRA----------------------------AKRKERRFTLVLGVVMGa 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 288 FAVCYFPVHLFNILrYADALRFVAPRmiqVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15059  205 FVLCWLPFFFTYPL-VVVCKTCGVPE---LLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
52-348 7.55e-27

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 107.45  E-value: 7.55e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15061    2 LISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKstKRRAKIIILVIWIIAFLLALpevIVADLTRFVKRQYIDLLIFCGPQWSDKT 211
Cdd:cd15061   82 LCTASILNLCCISLDRYFAITYPLKYR--TKRSRRLAITMILAVWVISL---LITSPPLVGPSWHGRRGLGSCYYTYDKG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 nQVVYQSVIIvlmYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIGFAVC 291
Cdd:cd15061  157 -YRIYSSMGS---FFLPLLLMLFVYLRIFRV----------------------------IAKERKTAKTLAIVVGCFIVC 204
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 292 YFPvhlFNILRYADAlrFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15061  205 WLP---FFIMYLIEP--FCDCQFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-347 8.93e-27

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 107.96  E-value: 8.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSD-VTETWYFGFAMCKIALFLQTTSVAVS 136
Cdd:cd15132    9 ILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDL-LILLCLPFDLYRLwKSRPWIFGEFLCRLYHYISEGCTYAT 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 137 VFTLSAISVERWYAICYPLRFK--STKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPqwsdkTNQV 214
Cdd:cd15132   88 ILHITALSIERYLAICFPLRAKvlVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDFSRECKH-----TPYA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 215 VYQSVIIVLM------YLLPLVLMTVTYSMIAVVLWtgkipgaiESANRPMMDGNVNRAeeqlESRKKAAKMLITVVIGF 288
Cdd:cd15132  163 VSSGLLGIMIwvtttyFFLPMLCLSFLYGFIGRKLW--------KSKNDLRGPNAAARE----RSHRQTVRILAVVVLAF 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 289 AVCYFPVHLFNILrYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGA 347
Cdd:cd15132  231 IICWLPFHIGRIL-FANTEDYRTMMFSQYFNIVAMQLFYLSASINPILYNLISRKYRAA 288
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
50-348 1.06e-26

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 107.05  E-value: 1.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVglSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVT-ETWYFGFAMCKIALFL 128
Cdd:cd15053    3 WALFLLLLPLLTV--FGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNgGKWYLGPILCDIYIAM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 129 QTTSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQyidLLIFCGPQ 206
Cdd:cd15053   81 DVMCSTASIFNLCAISIDRYIAVTQPIKYarQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPE---ECRFYNPD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WsdktnqVVYQSVIivlMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnRAEeqlesrKKAAKMLITVVI 286
Cdd:cd15053  158 F------IIYSSIS---SFYIPCIVMLLLYYRIFRAL----------------------RRE------KKATKTLAIVLG 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 287 GFAVCYFPVHLFNILR-YADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15053  201 VFLFCWLPFFTLNILNaICPKLQNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
53-339 1.56e-26

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 107.25  E-value: 1.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGL---SGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15055    1 VLLYIVLSSISLltvLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPevivadltrfvkrqyidLLIFCGPQW 207
Cdd:cd15055   81 YILTSASIFNLVLIAIDRYVAVCDPLLYptKITIRRVKICICLCWFVSALYSSV-----------------LLYDNLNQP 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 S-DKTN----------QVVYQSVIIVLMYLLPLVLMTVTYSMI-AVVLWTGKipgAIESanrpMMDGNVNRAEEQLESRK 275
Cdd:cd15055  144 GlIRYNscygecvvvvNFIWGVVDLVLTFILPCTVMIVLYMRIfVVARSQAR---AIRS----HTAQVSLEGSSKKVSKK 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 276 ---KAAKMLITVVIGFAVCYFPVHLFNIlryADALRFVAPRMIQVLSmishWLPYLNSSINPIIYNF 339
Cdd:cd15055  217 serKAAKTLGIVVGVFLLCWLPYYIVSL---VDPYISTPSSVFDVLI----WLGYFNSCLNPLIYAL 276
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
52-341 2.95e-26

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 106.56  E-value: 2.95e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIV--GLSGNVLvCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLL---SDVTETWYFGFAM--CKI 124
Cdd:cd14978    1 VLYGYVLPVICifGIIGNIL-NLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLpyiADYSSSFLSYFYAyfLPY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 125 ALFLQTTSVAVSVFTLSAISVERWYAICYPLRFK--STKRRAKIIILVIWIIAFLLALPEVivadLTRFVKRQYIDLLIF 202
Cdd:cd14978   80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKARtwCTPRRARRVILIIIIFSLLLNLPRF----FEYEVVECENCNNNS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 203 CGPQWSDKTNQ------VVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesANRPMMDGNVNRAEEQLESRKK 276
Cdd:cd14978  156 YYYVIPTLLRQnetyllKYYFWLYAIFVVLLPFILLLILNILLIRALRKSK-------KRRRLLRRRRRLLSRSQRRERR 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 277 AAKMLITVVIGFAVCYFPVHLFNILRYADAlRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd14978  229 TTIMLIAVVIVFLICNLPAGILNILEAIFG-ESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFS 292
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
52-348 5.89e-26

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 105.27  E-value: 5.89e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15974    3 IPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVAD-ELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDGV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLrfKSTKRR----AKIIILVIWIIAFLLALPEVIVADLTRFVKRqyidllifCGPQW 207
Cdd:cd15974   82 NQFTSIFCLTVMSIDRYLAVVHPI--KSTKWRrprvAKLINATVWTLSFLVVLPVIIFSDVQPDLNT--------CNISW 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNqvVYQSVII----VLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeeqleSRKKAAKMLIT 283
Cdd:cd15974  152 PEPVS--VWSTAFIiytaVLGFFGPLLVICLCYLLIVIKVKSSGLRVGSTKRRK---------------SERKVTRMVVI 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 284 VVIGFAVCYFPVHLFNILRyadaLRFVAPR--MIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15974  215 IVVVFVFCWLPFYMLNIVN----LIVILPEepAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
52-348 1.25e-25

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 104.56  E-value: 1.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15092    3 IVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALAD-TLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTrfVKRQYIDLLIFCGPQ--- 206
Cdd:cd15092   82 NMFTSTFTLTAMSVDRYVAICHPIKALDvrTPHKAKVVNVCIWALASVVGVPVMVMGSAQ--VEDEEIECLVEIPTPqdy 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDktnqvVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIpgaiesanrpmmdgnVNRAEEQLESRKKAAKMLITVVI 286
Cdd:cd15092  160 WDP-----VFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRL---------------LSGSKEKDRNLRRITRLVLVVVA 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 287 GFAVCYFPVHLFNIlryADALRFVAPRMIQVlsMISHW---LPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15092  220 VFVGCWTPIQIFVL---AQGLGVQPSSETAV--AILRFctaLGYVNSSLNPVLYAFLDENFKACF 279
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
52-348 1.48e-25

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 104.27  E-value: 1.48e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15091    3 ITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD-ALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLrfKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSDKT 211
Cdd:cd15091   82 NMFTSIFTLTMMSVDRYIAVCHPV--KALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSLQFPDDD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 N---QVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpMMDGnvnrAEEQLESRKKAAKMLITVVIGF 288
Cdd:cd15091  160 YswwDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVR-----------LLSG----SREKDRNLRRITRLVLVVVAVF 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 289 AVCYFPVHLFNILryaDALRFVaPRMIQVLSMISHW--LPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15091  225 VVCWTPIHIFILV---EALGSV-SHSTAAVSSYYFCiaLGYTNSSLNPILYAFLDENFKRCF 282
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
53-339 1.88e-25

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 104.10  E-value: 1.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIcLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd14975    4 CTLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLT-LPVWIYFLATGTWDFGLAACKGCVYVCAVS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPlrFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLifCGPQWSDKTN 212
Cdd:cd14975   83 MYASVFLITLMSLERFLAVSRP--FVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGM--CKYRHYSDGQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnrAEEQLESRKKAAKMLITVVIGFAVCY 292
Cdd:cd14975  159 LVFHLLLETVVGFAVPFTAVVLCYSCLLRRL-----------------------RRRRFRRRRRTGRLIASVVVAFAACW 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 293 FPVHLFNILRYADAL---RFVAPRMIQVLSM---ISHWLPYLNSSINPIIYNF 339
Cdd:cd14975  216 LPYHVGNLLEVVSELiggSKMAGTLGKVAEAgrpIAGALAFLSSSINPLLYAF 268
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
51-348 2.62e-25

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 103.20  E-value: 2.62e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQ 129
Cdd:cd15067    1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTgGYWLFGRDWCDVWHSFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIvadLTRFVKRQYID--LLIFcgp 205
Cdd:cd15067   81 VLASTASILNLCVISLDRYWAITDPISYPSrmTKRRALIMIALVWICSALISFPAIA---WWRAVDPGPSPpnQCLF--- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 qwsdkTNQVVYQSVIIVLMYLLPLVLMTVTYsmiavvlwtgkipgaiesanrpmmdGNVNRAEEQlesRKKAAKMLITVV 285
Cdd:cd15067  155 -----TDDSGYLIFSSCVSFYIPLVVMLFTY-------------------------YRIYRAAAK---EQKAAKTLGIVM 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 286 IGFAVCYFPVHLFNILryadaLRFVAPRMIQ---VLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15067  202 GVFILCWLPFFVTNIL-----IGFCPSNCVSnpdILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
53-339 2.69e-25

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 104.02  E-value: 2.69e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15195    4 VLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKR-----QYIDLLIFcgpqw 207
Cdd:cd15195   84 MYLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEqpgfhQCVDFGSA----- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVvlwtgKIPGAIESANRPMMDGNVNRAEEQLE-SRKKAAKMLITVVI 286
Cdd:cd15195  159 PTKKQERLYYFFTMILSFVIPLIITVTCYLLILF-----EISKMAKRARDTPISNRRRSRTNSLErARMRTLRMTALIVL 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 287 GFAVCYFPVHLFNILRYAD--ALRFVAPRMIQVLSMIShwlpYLNSSINPIIYNF 339
Cdd:cd15195  234 TFIVCWGPYYVLGLWYWFDkeSIKNLPPALSHIMFLLG----YLNPCLHPIIYGV 284
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
51-337 3.21e-25

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 104.07  E-value: 3.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15058    2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLA-LPevIVADLTRFVKRQyiDLLIFCGPQW 207
Cdd:cd15058   82 LCVTASIETLCVIAVDRYIAITRPLRYQVllTKRRARVIVCVVWIVSALVSfVP--IMNQWWRANDPE--ANDCYQDPTC 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVL-----WTGKIPGAIESANRPMMDGNVNRAEEQLESRK------- 275
Cdd:cd15058  158 CDFRTNMAYAIASSVVSFYIPLLIMIFVYARVFLIAtrqlqLIDKRRLRFQSECPAPQTTSPEGKRSSGRRPSrltvvke 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 276 -KAAKMLITVVIGFAVCYFPVHLFNILRYADalRFVAPRMIQVLsmiSHWLPYLNSSINPIIY 337
Cdd:cd15058  238 hKALKTLGIIMGTFTLCWLPFFIANIINVFN--RNLPPGEVFLL---LNWLGYINSGLNPIIY 295
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
52-341 4.15e-25

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 103.26  E-value: 4.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNR--SMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15002    2 VPILLGVICLLGFAGNLMVIGILLNNArkGKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKSTK-RRAKIIILVIWIIAFLLALPEVIVadltRFVKRQYIDLLIFCGPQWS 208
Cdd:cd15002   82 HACMAAKSFTIAVLAKACYMYVVNPTKQVTIKqRRITAVVASIWVPACLLPLPQWLF----RTVKQSEGVYLCILCIPPL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiesanRPMMDGNVNRAEEQlesRKKAAKMLITVVIGF 288
Cdd:cd15002  158 AHEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQ------------RRGTKTQNLRNQIR---SRKLTHMLLSVVLAF 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPrmIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15002  223 TILWLPEWVAWLWLIHIKSSGSSP--PQLFNVLAQLLAFSISSVNPIIFLLMS 273
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-339 4.85e-25

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 103.30  E-value: 4.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  46 DDWE--WGII-ILYALTFIVGLSGNVLVCFAVWRNRSMR-TVTNIFIVNLAIADLAvIIICLPptLLSDVTET---WYFG 118
Cdd:cd15190    4 TEWKpsYALIpVIYMLVFVLGLSGNGLVLWTVFRSKRKRrRSADTFIANLALADLT-FVVTLP--LWAVYTALgyhWPFG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 119 FAMCKIALFLQTTSVAVSVFTLSAISVERWYAICYPLrfKSTKRRAKIIILVIW----IIAFLLALPEVIVadltRFVKR 194
Cdd:cd15190   81 SFLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSL--ASAKLRSRTSGIVALgviwLLAALLALPALIL----RTTSD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 195 QYIDLLIFCGPQWS---DKTNQVVYQSVI----IVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanRPMMDGNVNRA 267
Cdd:cd15190  155 LEGTNKVICDMDYSgvvSNESEWAWIAGLglssTVLGFLLPFLIMLTCYFFIG----------------RTVARHFSKLR 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 268 EEQLESRKKAAKMLITVVIGFAVCYFPVHLFNILRYADALRFVA-PRMIQVLSMISH----WLPYLNSSINPIIYNF 339
Cdd:cd15190  219 RKEDKKKRRLLKIIITLVVTFALCWLPFHLVKTLYALMYLGILPfSCGFDLFLMNAHpyatCLAYVNSCLNPFLYAF 295
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
50-337 4.90e-25

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 102.39  E-value: 4.90e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIvGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTET-WYFGFAMCKIALFL 128
Cdd:cd15052    2 WAALLLLLLVIA-TIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGvWPLPLVLCLLWVTL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 129 QTTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIW--IIAFLLALPEVIVADLTRFVKRQYIDLLIFCGpq 206
Cdd:cd15052   81 DVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIvwLISIGISSPIPVLGIIDTTNVLNNGTCVLFNP-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 wsdktNQVVYQSVIivlMYLLPLVLMTVTYSMiavvlwTGKIpgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVI 286
Cdd:cd15052  159 -----NFVIYGSIV---AFFIPLLIMVVTYAL------TIRL----------------------LSNEQKASKVLGIVFA 202
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 405966368 287 GFAVCYFPVHLFNILryADALRFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15052  203 VFVICWCPFFITNIL--TGLCEECNCRISPWLLSVFVWLGYVSSTINPIIY 251
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-348 6.26e-25

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 103.01  E-value: 6.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSV 137
Cdd:cd15976    9 LVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 138 FTLSAISVERWYAICYPLRFKST--KRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQyiDLLIFCGPQWSDKTNQVV 215
Cdd:cd15976   89 LSLCALSIDRYRAVASWSRIKGIgvPKWTAVEIVLIWVVSIILAVPEAIGFDMITMDYKG--ELLRICLLHPIQKTAFMQ 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 216 YQSV-----IIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmDGNVNRAEEQLESRKKAAKMLITVVIGFAV 290
Cdd:cd15976  167 FYKTakdwwLFSFYFCLPLACTAVFYTLMTCEMLRKK-------------NGMQIALNDHLKQRREVAKTVFCLVLVFAL 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 291 CYFPVHLFNILRYA-----DALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15976  234 CWLPLHLSRILKLTiydekDPNRCELLSFFLVLDYIGINMASLNSCINPIALYLVSKRFKNCF 296
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
58-341 1.20e-24

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 101.90  E-value: 1.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSV 137
Cdd:cd15402    9 FTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 138 FTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLtrfvkrQYIDLLIFCGPQWSDKTnqvV 215
Cdd:cd15402   89 FNITGIAINRYCYICHSLKYDKlySDKNSLCYVLLIWVLTVAAIVPNLFVGSL------QYDPRIYSCTFAQSVSS---A 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 216 YQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaIESANRPMMDgnvNRAEEQLESRKKAAKMLITVVIgFAVCYFPV 295
Cdd:cd15402  160 YTIAVVFFHFILPIIIVTFCYLRIWILV--------IQVRRRVKPD---NKPKLKPHDFRNFVTMFVVFVL-FAVCWAPL 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 405966368 296 HLFNILRYADALRFVaPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15402  228 NFIGLAVAVDPETIV-PRIPEWLFVASYYMAYFNSCLNAIIYGLLN 272
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
52-348 1.39e-24

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 101.42  E-value: 1.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGL--SGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15063    1 LISLLVLTFLNVLvvLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVA-DLTRFVKRQYIDLLIFCGPQ 206
Cdd:cd15063   81 VWMCTASILNLCAISLDRYLAITRPIRYPSlmSTKRAKCLIAGVWVLSFVICFPPLVGWnDGKDGIMDYSGSSSLPCTCE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQVVYQSviiVLMYLLPLVLMTVTYSMIAVvlwtgkipgaieSANRpmmdgnvnraeeqlesRKKAAKMLITVVI 286
Cdd:cd15063  161 LTNGRGYVIYSA---LGSFYIPMLVMLFFYFRIYR------------AARM----------------ETKAAKTVAIIVG 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 287 GFAVCYFPVHLFNILRYadalrFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15063  210 CFIFCWLPFFTVYLVRA-----FCEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
52-341 1.52e-24

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 101.38  E-value: 1.52e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15398    3 LIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVI---VADLTRFVKRQYIDLLIFCGPQWS 208
Cdd:cd15398   83 SVMVSTLMLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSPLPVfhkIVDLSETFNLESLKNKYLCIESWP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiESANRpmmdgnvnraeeqleSRKKAAKMLItVVIGF 288
Cdd:cd15398  163 SDSYRIAFTISLLFVQYILPLVCLTVSHTSVC------------RSVKR---------------SRSVFYRLTI-VILAF 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 289 AVCYFPVHLFNILRYADAlRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15398  215 AVSWMPLHLFHLVTDFNA-NLISNRHFKLVYCICHLLGMLSCCLNPILYGFLN 266
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
54-348 2.71e-24

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 101.14  E-value: 2.71e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15977    5 ILSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKST--KRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYiDLLIFCGPQWSDKT 211
Cdd:cd15977   85 GITVLSLCALSIDRYRAVASWSRIRGIgiPVWKAVEVTLIWAVAIIVAVPEAIAFDMVEIDYRGQ-TLLVCMLPMEQTSS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSV----IIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmDGNVNRAEEQLESRKKAAKMLITVVIG 287
Cdd:cd15977  164 FMRFYQDVkdwwLFGFYFCLPLACTGVFYTLMSCEMLSIK-------------NGMRIALNDHMKQRREVAKTVFCLVVI 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 288 FAVCYFPVHLFNILR-----YADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15977  231 FALCWLPLHLSRILKktiydVKDPQRCELLSFLLVMDYTGINMASLNSCINPVALYFVSRKFKNCF 296
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
52-348 2.75e-24

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 100.65  E-value: 2.75e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15972    3 IPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALAD-ELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRfkSTKRR----AKIIILVIWIIAFLLALPEVIVADLTRFVKRqyidllifCGPQW 207
Cdd:cd15972   82 NQFTSIFCLTVMSVDRYLAVVHPIR--SSKWRkppvAKTVNATVWALSFLVVLPVVIFSGVPGGMGT--------CHIAW 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNqvVYQSVIIV----LMYLLPLVLMTVTYSMIAVvlwtgkipgAIESANRPMMDGNVNRAeeqlESRKKAAKMLIT 283
Cdd:cd15972  152 PEPAQ--VWRAGFIIytatLGFFCPLLVICLCYLLIVV---------KVRSSGRRVRATSTKRR----GSERKVTRMVVI 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 284 VVIGFAVCYFPVHLFNILRYADALRfVAPRMIQVLSMISHwLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15972  217 VVAAFVLCWLPFYALNIVNLVCPLP-EEPSLFGLYFFVVV-LSYANSCANPIIYGFLSDNFKQGF 279
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
52-348 2.78e-24

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 100.69  E-value: 2.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15971    3 LTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIAD-ELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLrfKSTK----RRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDlLIFCGPQW 207
Cdd:cd15971   82 NQFTSIFCLTVMSIDRYLAVVHPI--KSAKwrkpRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCT-IIWPGESS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQsviIVLMYLLPLVLMTVTYSMIAVVLWTGKIpgAIESANRPmmdgnvnraeeqlESRKKAAKMLITVVIG 287
Cdd:cd15971  159 AWYTGFIIYT---FILGFFVPLTIICLCYLFIIIKVKSSGI--RVGSSKRK-------------KSEKKVTRMVSIVVAV 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 288 FAVCYFPVHLFNILRYADALRFvAPRMIQVLSMIShWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15971  221 FVFCWLPFYIFNVSSVSVSISP-TPGLKGMFDFVV-VLSYANSCANPILYAFLSDNFKKSF 279
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
51-339 3.11e-24

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 100.81  E-value: 3.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADL--AVIIiclpPTLLSDVTETWYFGFAMCKIALFL 128
Cdd:cd15178    2 ALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLlfALTL----PFWAVSVVKGWIFGTFMCKLVSLL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 129 QTTSVAVSVFTLSAISVERWYAICYPLRFKSTKRR-AKIIILVIWIIAFLLALPevivADLTRFVKRQYIDLLIFC---- 203
Cdd:cd15178   78 QEANFYSGILLLACISVDRYLAIVHATRALTQKRHlVKFVCAGVWLLSLLLSLP----ALLNRDAFKPPNSGRTVCyenl 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 GPQWSDKTnQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgnvnraeeqLESRKKAAKMLIT 283
Cdd:cd15178  154 GNESADKW-RVVLRILRHTLGFLLPLVVMLFCYGFTIKTLLQTR-----------------------SFQKHRAMRVIFA 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 284 VVIGFAVCYFPVH---LFNILRYADALRFVAPR--MIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15178  210 VVLAFLLCWLPYNvtvLIDTLMRTKLITETCELrnHVDVALYVTQILGFLHSCINPVLYAF 270
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
60-348 3.59e-24

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 100.91  E-value: 3.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  60 FIVGLSGNVLVCFAVWRNR-SMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVF 138
Cdd:cd15383   11 FVLSACSNLAVLWSATRNRrRKLSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSSAF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 139 TLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIvadLTRFVKRQYIDLLIFCGPQWSDKTN--QVVY 216
Cdd:cd15383   91 VTVVISLDRHAAILNPLAIGSARRRNRIMLCAAWGLSALLALPQLF---LFHTVTATPPVNFTQCATHGSFPAHwqETLY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 217 QSVIIVLMYLLPLVLMTVTYSMIAVvlwtgkipgaieSANRPMMDGNVNRAEEQL---------ESRKKAAKMLITVVIG 287
Cdd:cd15383  168 NMFTFFCLFLLPLLIMIFCYTRILL------------EISRRMKEKKDSAKNEVAlrsssdnipKARMRTLKMTIVIVSS 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 288 FAVCYFPVHLFNILRYadalrfVAPRMIQ--VLSMISHWL---PYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15383  236 FIVCWTPYYLLGLWYW------FSPEMLEqtVPESLSHILflfGLLNACLDPLIYGLFTISFRRGL 295
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-348 6.81e-24

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 100.29  E-value: 6.81e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETW-----YFGFAMCKIALFLQTTS 132
Cdd:cd15128    9 LIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWpfgdqPFGQFLCKLVPFIQKAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKST--KRRAKIIILVIWIIAFLLALPEVIVADLTRF-VKRQYIDLLIFCGPQWSD 209
Cdd:cd15128   89 VGITVLNLCALSVDRYRAVASWSRIQGIgiPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFnYKGVTLRTCLLRPETSFM 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmDGNVNRA-EEQLESRKKAAKMLITVVIGF 288
Cdd:cd15128  169 KFYIDVKDWWLFGFYFCLPLVCTAIFYTLMTCEMLRKR-------------NGMLRIAlNEHLKQRREVAKTVFCLVVIF 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 289 AVCYFPVHLFNILRYA-----DALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15128  236 ALCWLPLHLSRILKLTvydqnDPNRCELLSFLLVLDYFGINLATLNSCINPIALYFVSRKFKNCF 300
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
52-348 7.86e-24

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 100.31  E-value: 7.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTV---TNIFIVNLAIADLAVIIICLPPTLLSD--VTETWYFGFAMCKIAL 126
Cdd:cd15355    3 VTAIYLALFVVGTVGNSITLYTLARKKSLQHLqstVHYHLASLALSDLLILLLAMPVELYNFiwVHHPWAFGDAACRGYY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLtRFVKRQYIDLLIfCG 204
Cdd:cd15355   83 FLRDACTYATALNVASLSVERYLAICHPFKAKSlmSRSRTKKFISAIWLASALLAIPMLFTMGE-QNRSGTHPGGLI-CT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 PQWSDKTNQVVYQsVIIVLMYLLPLVLMTVTYSMIA----VVLWTGKIPGAIESANRPMMDGNVNRAEEQLESRKKAAKM 280
Cdd:cd15355  161 PIVDTSTLKVVIQ-VNAFLSFLFPMLVISVLNTLIAnqltVMVNQAEQENQVCTIGGQRTVLSVSMEPGRVQSLRHGVLV 239
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 281 LITVVIGFAVCYFPVHLFNIL-------RYADALRfvapRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15355  240 LRAVVIAFVVCWLPYHVRRLMfcyvsdeQWTTFLY----DFYHYFYMLTNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
52-340 9.07e-24

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 99.30  E-value: 9.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCF-AVWRNRsmRTVTNIFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQ 129
Cdd:cd14974    3 SLVLYALIFLLGLPGNGLVIWvAGFKMK--RTVNTVWFLNLALADF-LFCLFLPFLIVYIAMgHHWPFGSVLCKLNSFVI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQW 207
Cdd:cd14974   80 SLNMFASVFLLTAISLDRCLLVLHPVwaQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVEDYDL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 sDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnrAEEQLESRKKAAKMLITVVIG 287
Cdd:cd14974  160 -RRSRHKALTVIRFLCGFLLPLLIIAICYSVIAVKL-----------------------RRKRLAKSSKPLRVLLAVVVA 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 288 FAVCYFPVHLFNILRYADAlrFVAPRMIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd14974  216 FFLCWLPYHVFALLELVAA--AGLPEVVLLGLPLATGLAYFNSCLNPILYVFM 266
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
54-340 1.12e-23

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 99.24  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15314    5 IFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALpEVIVADLTrfVKRQYIDLLIFCGpqwsdkt 211
Cdd:cd15314   85 TASILNLCFISIDRYYAVCQPLLYRSkiTVRVVLVMILISWSVSALVGF-GIIFLELN--IKGIYYNHVACEG------- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVII-----VLMYLLPLVLMTVTYSMIAVVlwtgkipgAIESAnRPMMDGNVNRAEEQLESRKKAAKMLITVVI 286
Cdd:cd15314  155 GCLVFFSKVSsvvgsVFSFYIPAVIMLCIYLKIFLV--------AQRQA-RSIQSARTKSGASSSKMERKATKTLAIVMG 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 287 GFAVCYFPVHLFNI----LRYAdalrfVAPRMIQVLSmishWLPYLNSSINPIIYNFM 340
Cdd:cd15314  226 VFLLCWTPFFLCNIidpfINYS-----IPPVLIEVLN----WLGYSNSTLNPFIYAFF 274
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
52-337 2.01e-23

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 98.11  E-value: 2.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLS--GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15329    1 VLIGIVLLIIILGTvvGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQyidllifCgpQW 207
Cdd:cd15329   81 VLLCTASILNLCAISVDRYLVITRPLTYavKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPGV-------C--QV 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDktnQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVlwtgkipgaiesANRPMmdgnvnraeeqlesrkKAAKMLITVVIG 287
Cdd:cd15329  152 SQ---DFGYQIYATFGAFYIPLIVMLVLYYKIYRA------------AKSER----------------KAIKTLGIIMGA 200
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 405966368 288 FAVCYFPVHLFNILR--YADALRFVAPrmiQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15329  201 FTLCWLPFFILALLRpfLKPIKCSCIP---LWLSRLFLWLGYANSFLNPIIY 249
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
52-348 2.79e-23

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 98.28  E-value: 2.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPP-TLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15191    3 IPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADL-LFLATLPLwATYYSYGYNWLFGSVMCKICGSLLT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRF-KSTKRRAKIIILVIWIIAFLLALPEVIVADlTRFVKRQYIDLLIFCGPQWSD 209
Cdd:cd15191   82 LNLFASIFFITCMSVDRYLAVVYPLRSqRRRSWQARLVCLLVWVLACLSSLPTFYFRD-TYYIEELGVNACIMAFPNEKY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaieSANRPMMDGnvnraeeqlESRKKAAKMLITVVIGFA 289
Cdd:cd15191  161 AQWSAGLALMKNTLGFLIPLIVIATCYFGIGRHLL---------KTKGFGKNK---------QRRDKVLKMVAAVVLAFL 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 290 VCYFPVHlfnILRYADALRFVAPRM-IQVLSMISHWLPYL------NSSINPIIYNFMSVQTKGAF 348
Cdd:cd15191  223 ICWFPFH---VLTFLDALARMGVINnCWVITVIDKALPFAiclgfsNSCINPFLYCFVGNHFREKL 285
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
53-339 3.50e-23

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 98.27  E-value: 3.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTfIVGLSGNVLVCFAVWRNRSMR-TVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGfAMCKIALFLQTT 131
Cdd:cd15057    5 CILYLLV-LLTLLGNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFG-SFCDVWVSFDIM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVI----VADLTRFVKRQYIDllifcgP 205
Cdd:cd15057   83 CSTASILNLCVISVDRYWAISSPFRYERrmTRRRAFIMIAVAWTLSALISFIPVQlgwhRADDTSEALALYAD------P 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 QWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVlwTGKIPGAIESANRPMMDGNVNRAEEQLESRK--KAAKMLIT 283
Cdd:cd15057  157 CQCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRI--ARRQIRRIAALERAAQESTNPDSSLRSSLRRetKALKTLSI 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 284 VVIGFAVCYFPVHLFN-ILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15057  235 IMGVFVCCWLPFFILNcVLPFCDLRTAQFPCVPDTTFIVFVWLGWANSSLNPIIYAF 291
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
52-348 3.51e-23

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 98.19  E-value: 3.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15065    2 IGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSD 209
Cdd:cd15065   82 CSTASILNLCAISLDRYIHIKKPLKYERwmTTRRALVVIASVWILSALISFLPIHLGWHRLSQDEIKGLNHASNPKPSCA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMI-------AVVLWTGKIPGAIESANRPMMDGNVNRaeEQLESRKKAAKMLi 282
Cdd:cd15065  162 LDLNPTYAVVSSLISFYIPCLVMLLIYSRLylyarkhVVNIKSQKLPSESGSKFQVPSLSSKHN--NQGVSDHKAAVTL- 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 283 TVVIG-FAVCYFPVHLFNILRYADAlRFVAPRMIQVLSmishWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15065  239 GIIMGvFLICWLPFFIINIIAAFCK-TCIPPKCFKILT----WLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
52-348 4.51e-23

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 97.94  E-value: 4.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15056    3 LSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAIC-YPLRFKSTKRRakiiilVIWIIAFLLALPEVI--VADLTRFVKRQYIDLLIFCGPQWS 208
Cdd:cd15056   83 LTTASIMHLCCIALDRYYAICcQPLVYKMTPLR------VAVMLGGCWVIPTFIsfLPIMQGWNHIGIEDLIAFNCASGS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVV---YQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIpgAIESANRPMMDGNVN--RAEEQLESRKKAAKMLIT 283
Cdd:cd15056  157 TSCVFMVnkpFAIICSTVAFYIPALLMVLAYYRIYVAAREQAH--QIRSLQRAGSSNHEAdqHRNSRMRTETKAAKTLGI 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 284 VVIGFAVCYFPVHLFNILRyadalRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15056  235 IMGCFCVCWAPFFVTNIVD-----PFIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
54-340 6.21e-23

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 97.12  E-value: 6.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIClpPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15176    5 VFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTL--PFWAADAVNGWVLGTAMCKITSALYTMNF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLtRFVKRQYIDLLIFcgPQWSDKTNQ 213
Cdd:cd15176   83 SCGMQFLACISVDRYVAITKATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTV-RENSDRYRCLPVF--PPSLVTSAK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 VVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtGKIPGAiesanrpmmdgnvnraeeqleSRKKAAKMLITVVIGFAVCYF 293
Cdd:cd15176  160 ATIQILEVLLGFVLPFLVMVFCYSRVARAL--SRTPNV---------------------KKSRALKVLLAVVGVFIVTQL 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 405966368 294 PVHLFNILRYADALRFV-----APRMIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15176  217 PYNVVKFYRAIDVIYLLitdcsMSKTLDIAIQVTESIALFHSCLNPVLYVFM 268
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
52-339 2.11e-22

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 95.52  E-value: 2.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPptLLSDVTET---WYFGFAMCKIALFL 128
Cdd:cd14985    3 IPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADL-VFVLTLP--LWATYTANqydWPFGAFLCKVSSYV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 129 QTTSVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIVADLtRFVKRQYIDLLIFCGPQ 206
Cdd:cd14985   80 ISVNMFASIFLLTCMSVDRYLAIVHPVasRRLRRRRQARVTCALIWVVACLLSLPTFLLRSL-QAIENLNKTACIMLYPH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQVVyqsVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgnvNRAEEQLESRKKAAKMLITVVI 286
Cdd:cd14985  159 EAWHFGLSL---ELNILGFVLPLLIILTCYFHIARSLRKRY-----------------ERTGKNGRKRRKSLKIIFALVV 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 287 GFAVCYFPVHLFNILRYADALRFVAP----RMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd14985  219 AFLVCWLPFHFFKFLDFLAQLGAIRPcfweLFLDLGLPIATCLAFTNSCLNPFIYVF 275
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
52-348 2.53e-22

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 95.36  E-value: 2.53e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15970    3 ISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIAD-ELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRR--AKIIILVIWIIAFLLALPEVIVADLTrfvkrQYIDLLIFCGPQWSD 209
Cdd:cd15970   82 NMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPtvAKMVNLGVWVFSILVILPIIIFSNTA-----PNSDGSVACNMQMPE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQ--VVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeeqleSRKKAAKMLITVVIG 287
Cdd:cd15970  157 PSQRwlAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQRKR---------------SERKITLMVMMVVTV 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 288 FAVCYFPVHLFNIlryadaLRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15970  222 FVICWMPFYVVQL------VSVFVGQHDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
51-341 2.65e-22

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 95.36  E-value: 2.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15401    2 VLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLA--LPEVIVADLtrfvkrQYIDLLIFCGpqwS 208
Cdd:cd15401   82 LSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAaiVPNFFVGSL------QYDPRIYSCT---F 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaIESANRPMMDGNVNRAEEQLesrKKAAKMLITVVIgF 288
Cdd:cd15401  153 AQTVSSSYTITVVVVHFIVPLSIVTFCYLRIWVLV--------IQVKHRVRQDSKQKLKANDI---RNFLTMFVVFVL-F 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 289 AVCYFPVHLFNILRYADALRfVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15401  221 AVCWGPLNFIGLAVAINPLK-VAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLN 272
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
51-339 4.77e-22

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 94.71  E-value: 4.77e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILyaLTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15083    4 GIFIL--IIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIvaDLTRFVKRQYidlLIFCGPQW- 207
Cdd:cd15083   82 LFGIMSINTLAAIAVDRYLVITRPMkaSVRISHRRALIVIAVVWLYSLLWVLPPLF--GWSRYVLEGL---LTSCSFDYl 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMI-AVVLWTGKipgAIESANRPMMDGNVNRAEEQLESRKKAAKMLITVVI 286
Cdd:cd15083  157 SRDDANRSYVICLLIFGFVLPLLIIIYCYSFIfRAVRRHEK---AMKEMAKRFSKSELSSPKARRQAEVKTAKIALLLVL 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 287 GFAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHwlpyLNSSINPIIYNF 339
Cdd:cd15083  234 LFCLAWTPYAVVALIGQFGYLEVLTPLATAIPAAFAK----TSAIYNPVIYAF 282
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
54-347 5.95e-22

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 94.46  E-value: 5.95e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTET-WYFGFAMCKIALFLQTTS 132
Cdd:cd15968    5 ICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADL-LYALSLPLLIYNYAMRDrWLFGDFMCRLVRFLFYFN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLR--FKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYidllifCGPQWSDK 210
Cdd:cd15968   84 LYGSILFLTCISVHRYLGICHPMRpwHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTV------CYDLAPPA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 --TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeeqlesRKKAAKMLITVVIGF 288
Cdd:cd15968  158 lfPHYVPYGMALTVSGFLLPFSIILWCYCLVVRTLCRTLGPAEPPAQAR----------------RRKSIRTIVTVTLLF 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 289 AVCYFPVHLF-NILRYADALRFVAPRMIQVLSM---ISHWLPYLNSSINPIIYnFMSVQTKGA 347
Cdd:cd15968  222 ALCFLPFHITrTIYLAVRVTPGVPCHVLEAVAAcykITRPLASANSVLNPLLY-FLTKKKFGR 283
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
54-348 6.69e-22

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 94.54  E-value: 6.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYF-----GFAMCKIALFL 128
Cdd:cd15975    5 VLSCIIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFddssfGVFLCKLVPFL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 129 QTTSVAVSVFTLSAISVERWYAICYPLRFKST--KRRAKIIILVIWIIAFLLALPEVIVADLTRFVKR--QYIDLLIFCG 204
Cdd:cd15975   85 QKASVGITVLNLCALSVDRYRAVASWSRVQGIgiPLITAIEIFSIWVLSFILAIPEAIGFVMVPFEYNgeQYRTCMLNAT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 PQWSDktnqvVYQSV----IIVLMYLLPLVLMTVTYSMIAVvlwtgkipgaiESANRpmMDGNVNRA-EEQLESRKKAAK 279
Cdd:cd15975  165 TKFMN-----FYVDAkdwwLFGFYFCVPLACTAIFYTLMTC-----------EMLNR--RKGSLRIAlSEHLKQRREVAK 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 280 MLITVVIGFAVCYFPVHLFNILRYA-----DALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15975  227 TVFCLVVIFALCWFPLHLSRILKKTvynenDPRRCELLSFLLVMDYISINLATMNSCINPIALYFVSKKFKNCF 300
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
32-341 7.49e-22

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 95.23  E-value: 7.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  32 DEEYLDYLEDYVFpDDWEWGIIILYALTFIVGLSGNVLVCFaVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDV 111
Cdd:PHA03087  24 DEDYADCDLNIGY-DTNSTILIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDL-LFVMTLPFQIYYYI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 112 TETWYFGFAMCKIALFLQTTSVAVSVFTLSAISVERWYAICYPLrfKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRF 191
Cdd:PHA03087 101 LFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPV--KSNKINTVKYGYIVSLVIWIISIIETTPILFVYT 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 192 VKRQYiDLLIfCGPQWSDKTN--QVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPgaiesanrpmmdgnvnraee 269
Cdd:PHA03087 179 TKKDH-ETLI-CCMFYNNKTMnwKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKS-------------------- 236
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 270 qlESRKKAAKMLITVVIGFAVCYFPVHLFNILRYADALRFV----APRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:PHA03087 237 --KKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKsgckAVKYIQYALHVTEIISLSHCCINPLIYAFVS 310
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
48-348 8.45e-22

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 93.48  E-value: 8.45e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  48 WEWGIIILyaltfIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALF 127
Cdd:cd15210    4 AVWGIVFM-----VVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 128 LQTTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAF----LLALPEVIVADLTrFVKRqyidlliFC 203
Cdd:cd15210   79 LRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFsfgsFLPLWLGIWGRFG-LDPK-------VC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 GPQWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSmiavvlwtgkipgaiesanrpmmdgnvnRAEEqlesrKKAAKMLIT 283
Cdd:cd15210  151 SCSILRDKKGRSPKTFLFVFGFVLPCLVIIICYA----------------------------RRED-----RRLTRMMLV 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 284 VVIGFAVCYFPVHLFNIlryADALRFVaprmiQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15210  198 IFLCFLVCYLPITLVNV---FDDEVAP-----PVLHIIAYVLIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
54-348 1.08e-21

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 93.11  E-value: 1.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQTTS 132
Cdd:cd15310    5 LSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTgGVWNFSRICCDVFVTLDVMM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFK-----STKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFcgpqw 207
Cdd:cd15310   85 CTASILNLCAISIDRYTAVVMPVHYQhgtgqSSCRRVSLMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDF----- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 sdktnqVVYQSVIivlMYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIG 287
Cdd:cd15310  160 ------VIYSSVV---SFYLPFGVTLLVYVRIYVV----------------------------LLREKKATQMLAIVLGA 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 288 FAVCYFPVHLFNILRYADALRFVAPRMIQVlsmiSHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15310  203 FIVCWLPFFLTHILNTHCQACHVPPELYSA----TTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
54-337 1.10e-21

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 93.20  E-value: 1.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15213    5 ILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERwYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQyidllIFCGPQWSDKTNQ 213
Cdd:cd15213   85 LEGVAILLIISVDR-YLIIVQRQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPRA-----PQCVLGYTESPAD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 VVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgnvnraeeqlesrKKAAKMLITVVIGFAVCYF 293
Cdd:cd15213  159 RIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSFK---------------------------TRAFTTILILFIGFSVCWL 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 405966368 294 PVHLFNILryadaLRFVAPRMI-QVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15213  212 PYTVYSLL-----SVFSRYSSSfYVISTCLLWLSYLKSAFNPVIY 251
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
52-348 1.25e-21

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 93.15  E-value: 1.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15049    3 ICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVI-----VADLTRFVKRQYIDLLifcg 204
Cdd:cd15049   83 ASNASVMNLLLISFDRYFSVTRPLtyRAKRTPKRAILMIALAWVISFVLWAPAILgwqyfVGERTVPDGQCYIQFL---- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 pqwsdktNQVVYQSVIIVLMYLLPLVLMTVTYSMIavvlwtgkipgAIESAnrpmmdgnvnraeeqleSRKKAAKMLITV 284
Cdd:cd15049  159 -------DDPAITFGTAIAAFYLPVLVMTILYWRI-----------YRETA-----------------RERKAARTLSAI 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 285 VIGFAVCYFPVHLFNILRYadalrFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15049  204 LLAFIITWTPYNILVLVST-----FCAKCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
52-348 1.97e-21

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 92.39  E-value: 1.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLS--GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15064    1 VLISVLLSLIILATilGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEvivadltrfvkrqyidLLIFCGPQW 207
Cdd:cd15064   81 VTCCTASILHLCVIALDRYWAITDAVEYahKRTPKRAAVMIALVWTLSICISLPP----------------LFGWRTPDS 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLM-----YLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnvnRAEEQlesrkKAAKMLI 282
Cdd:cd15064  145 EDPSECLISQDIGYTIFstfgaFYIPLLLMLILYWKIYRA-----------------------AARER-----KAAKTLG 196
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 283 TVVIGFAVCYFPVHLFNILRYADALRFVAPRMIQVLSmishWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15064  197 IILGAFIVCWLPFFLVALIVPLCSHCWIPLALKSFFL----WLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
52-343 2.97e-21

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 92.45  E-value: 2.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlaVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15180    3 LPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALAD--ILLLVTLPFWAVQAVHGWIFGTGLCKLAGAVFKI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKR--RAKIIILVIWIIAFLLALPEVIVADLTRfVKRQYIDLLIFCGPQwSD 209
Cdd:cd15180   81 NFYCGIFLLACISFDRYLSIVHAVQMYSRKKpmLVHLSCLIVWLFCLLLSIPDFIFLEATK-DPRQNKTECVHNFPQ-SD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnRAEEQLESRKKAAKMLITVVIGFA 289
Cdd:cd15180  159 TYWWLALRLLYHIVGFLLPLAVMVYCYTSILLRL----------------------LRSSQGFQKQRAIRVIVAVVVVFF 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 290 VCYFPVH---LFNILRYADALRFVAPR--MIQVLSMISHWLPYLNSSINPIIYNFMSVQ 343
Cdd:cd15180  217 LCWTPYNialLVDTLIDLSVLDRNCGTesRLDIALSVTSSLGYFHCCLNPLLYAFVGVK 275
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
58-341 5.27e-21

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 91.76  E-value: 5.27e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSV 137
Cdd:cd15209    9 VTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 138 FTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLtRFVKRQYIDLLIfcgpqwsdKTNQVV 215
Cdd:cd15209   89 FNITAIAINRYCYICHSLQYDRlySLRNTCCYLCLTWLLTVLAVLPNFFIGSL-QYDPRIYSCTFA--------QTVSTV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 216 YQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESanrpmmdgnvnRAEEQLESRKKAAKMLITVVIgFAVCYFPV 295
Cdd:cd15209  160 YTITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQ-----------RPKLKPADVRNFLTMFVVFVL-FAVCWAPL 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 405966368 296 HLFNILRYADALRfVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15209  228 NFIGLAVAINPKE-MAPKIPEWLFVASYFMAYFNSCLNAIIYGLLN 272
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
50-337 6.05e-21

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 91.89  E-value: 6.05e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15959    1 WLAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVI-WIIAFLLALPevIVADLTRF-----VKRQYIDlli 201
Cdd:cd15959   81 VLCVTASIETLCAIAVDRYLAITNPLRYEAlvTKRRARTAVCLVwAISAAISFLP--IMNQWWRDgadeeAQRCYDN--- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 202 fcgPQWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVL-----WTGKIPGAIESANRPMMDGnvNRAEEQLESR-- 274
Cdd:cd15959  156 ---PRCCDFVTNMPYAIVSSTVSFYVPLLVMIFVYVRVFVVAtrqvrLIRKDKVRFPPEESPPAES--RPACGRRPSRll 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 275 ----KKAAKMLITVVIGFAVCYFPVHLFNILRYadalrFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15959  231 aikeHKALKTLGIIMGTFTLCWLPFFVANIIKV-----FCRSLVPDPAFLFLNWLGYANSAFNPIIY 292
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
51-348 1.73e-20

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 89.97  E-value: 1.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15327    2 GVGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEvivadltrfvkrqyidLLIFCGPQWS 208
Cdd:cd15327   82 LCCTASILSLCVISVDRYVGVKHSLKYPTimTERKAGVILVLLWVSSMVISIGP----------------LLGWKEPPPP 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DK-----TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiesanrpmmdgnvnraeeQLESRKKAAKMLIT 283
Cdd:cd15327  146 DEsicsiTEEPGYALFSSLFSFYLPLMVILVMYFRVYVVAL-------------------------KFSREKKAAKTLAI 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 284 VVIGFAVCYFPvhLFNILRYADALRFVAPRmiQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15327  201 VVGVFILCWFP--FFFVLPLGSFFPALKPS--EMVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
53-339 2.58e-20

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 90.00  E-value: 2.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPptlLSDVTETwyfGF-AMCKIALFLQT- 130
Cdd:cd15068    4 ITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP---FAITIST---GFcAACHGCLFIACf 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 --TSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQ 206
Cdd:cd15068   78 vlVLTQSSIFSLLAIAIDRYIAIRIPLRYNGlvTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQVVYQSVIIVLMY----LLPLVLMTVTYsmIAVVLWTGKIPGAIESANRPMMdgnvnRAEEQLESRKKAAKMLI 282
Cdd:cd15068  158 VACLFEDVVPMNYMVYFNFfacvLVPLLLMLGVY--LRIFLAARRQLKQMESQPLPGE-----RARSTLQKEVHAAKSLA 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 283 TVVIGFAVCYFPVHLFNILRYADALRFVAPRMIQVLSMIshwLPYLNSSINPIIYNF 339
Cdd:cd15068  231 IIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIV---LSHTNSVVNPFIYAY 284
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
51-339 2.67e-20

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 89.49  E-value: 2.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILyALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIClPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15121    3 GIAIL-SLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTA-PFFLHFLSGGGWEFGSVVCKLCHYVCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRqyidlLIFCGP-QW 207
Cdd:cd15121   81 VSMYASIFLITLMSMDRCLAVAKPFlsQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNIN-----MKLCIPyHP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SdkTNQVVYQSVIIVLM-YLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVI 286
Cdd:cd15121  156 S--VGHEAFQYLFETITgFLLPFTAIVTCYSTIGRRLRSAR-----------------------FRRKRRTNRLVVLIIA 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 287 GFAVCYFPVHLFNILRYADALRFvAPRMIQVLSMISHWLP------YLNSSINPIIYNF 339
Cdd:cd15121  211 TFALFWLPYHVVNLIQVAGALQN-QAGNASVLKAAKLARPnvtalaFLSSSVNPVLYAF 268
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
51-337 3.93e-20

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 89.58  E-value: 3.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15958    2 GMSLLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIV---ADLTRFVKRQYIDllifcgP 205
Cdd:cd15958   82 LCVTASIETLCVIAIDRYLAITSPFRYQSllTRARAKGIVCTVWAISALVSFLPIMMhwwRDEDDQALKCYED------P 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 QWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYsmIAVVLWTGKIPGAIESANRPMMDGNV--NRAEEQLESR------KKA 277
Cdd:cd15958  156 GCCDFVTNRAYAIASSIISFYIPLLIMIFVY--LRVYREAKKQIKKIDKCEGRFHNTLTglGRKCKRRPSRilalreQKA 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 278 AKMLITVVIGFAVCYFPVHLFNILRYadalrFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15958  234 LKTLGIIMGVFTLCWLPFFLVNVVNV-----FNRELVPDWLFVFFNWLGYANSAFNPIIY 288
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
50-348 4.75e-20

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 88.46  E-value: 4.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15323    1 AGLAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVADltrfvKRQYIDLLIFCgpQW 207
Cdd:cd15323   81 VLFCTSSIVHLCAISLDRYWSVTQAVEYnlKRTPRRVKAIIVTVWLISAVISFPPLISMY-----RDPEGDVYPQC--KL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSviiVLMYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIG 287
Cdd:cd15323  154 NDETWYILSSC---IGSFFAPCLIMILVYIRIYRV----------------------------AKAREKRFTFVLAVVMG 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 288 -FAVCYFPV----HLFNILRYADALRfvaprmiQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15323  203 vFVVCWFPFffsySLYGICREACEVP-------EPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
56-348 6.46e-20

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 88.61  E-value: 6.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  56 YALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIcLPPTLLSDVTET-WYFGFAMCKIALFLQTTSVA 134
Cdd:cd15161    7 YILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLI-LPMRLVYHLSGNhWPFGEVPCRLAGFLFYLNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLRFKSTKRrakiIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSDKTNQV 214
Cdd:cd15161   86 ASLYFLACISVDRFLAIVHPVKSMKIRK----PLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQLYREKASRG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 215 VYQSVIIVlmYLLPLVLMTVTYSMIAVVLWTGkipgaiesanrpmmdgnvNRAEEQLesRKKAAKMLITVVIGFAVCYFP 294
Cdd:cd15161  162 ALVSLAVA--FTIPFVTTVTCYLLIIRSLRTG------------------KREEKPL--KDKAIKMIILVLTIFLICFVP 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 295 VHL---FNILRYADALRFVAPRMIQVLS-MISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15161  220 YHIsryIYILSHNGAGASCSSRRGLALAnRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
54-348 7.33e-20

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 88.03  E-value: 7.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15325    5 VILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKS--TKRRAkiiilviwiiafLLALPEVIVadltrfvkrqyIDLLIFCGPQWSDK- 210
Cdd:cd15325   85 TASIMSLCIISIDRYIGVSYPLRYPSimTERRG------------LLALLCVWV-----------LSLVISIGPLFGWKe 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 -----------TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiesanrpmmdgnvnraeeQLESRKKAAK 279
Cdd:cd15325  142 papedeticqiTEEPGYALFSALGSFYLPLAIILVMYCRVYVVAL-------------------------KFSREKKAAK 196
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 280 MLITVVIGFAVCYFPVHLFNILryadALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15325  197 TLGIVVGCFVLCWLPFFLVMPI----GSIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
52-339 8.28e-20

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 88.66  E-value: 8.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15317    3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTkrrakiiilviwiiaFLLALPEVIVAdLTRFVKRQYIDLLIFCG------P 205
Cdd:cd15317   83 LCTTSIFHLCFIAIDRYYAVCDPLRYPSK---------------ITVQVAWRFIA-IGWLVPGIYTFGLIYTGandeglE 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 QWSDKTNQV----VYQSVIIVLM----YLLPLVLMTVTYSMIAVVlwtgkipgAIESANRPMMDGNVNRAEEQLESR--- 274
Cdd:cd15317  147 EYSSEISCVggcqLLFNKIWVLLdfltFFIPCLIMIGLYAKIFLV--------ARRQARKIQNMEDKFRSSEENSSKasa 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 275 ---KKAAKMLITVVIGFAVCYFPvhlFNILRYADALRFVAPRMIQVLSMIshWLPYLNSSINPIIYNF 339
Cdd:cd15317  219 sreRKAAKTLAIVMGIFLFCWLP---YFIDTIVDEYSNFITPAIVFDAVI--WLGYFNSAFNPFIYAF 281
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
61-348 9.47e-20

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 87.64  E-value: 9.47e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVFTL 140
Cdd:cd15326   12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 141 SAISVERWYAICYPLRFKS--TKRRAkiiilviwiiafLLALPEVIVadltrfvkrqyIDLLIFCGPQWSDK-------- 210
Cdd:cd15326   92 CAISIDRYIGVRHSLQYPTivTRKRA------------ILALLGVWV-----------LSTVISIGPLLGWKepappddk 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 ----TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiesanrpmmdgnvnraeeQLESRKKAAKMLITVVI 286
Cdd:cd15326  149 vceiTEEPFYALFSSLGSFYIPLIVILVMYCRVYIVAL-------------------------KFSREKKAAKTLGIVVG 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 287 GFAVCYFPvhLFNILRYADAlrFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15326  204 MFILCWLP--FFIALPLGSL--FSHLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
53-339 1.21e-19

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 88.07  E-value: 1.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTL---LSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15069    4 VALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAItisLGFCTDFHSCLFLACFVLVLTQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TtsvavSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALpevivadlTRFVKRQYIDLLIFCGPQW 207
Cdd:cd15069   84 S-----SIFSLLAVAVDRYLAIKVPLRYKSlvTGKRARGVIAVLWVLAFGIGL--------TPFLGWNKAMSATNNSTNP 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKT------------NQVVYQSVIIVLMY----LLPLVLMTVTYSMIAVVlwtgkipgAIESANRPMMDGNvnrAEEQL 271
Cdd:cd15069  151 ADHGtnhscclisclfENVVPMSYMVYFNFfgcvLPPLLIMLVIYIKIFLV--------ACRQLQRTELMDH---SRTTL 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 272 ESRKKAAKMLITVVIGFAVCYFPVHLFN-ILRYADALRFVAPRMIQVLSMIshwLPYLNSSINPIIYNF 339
Cdd:cd15069  220 QREIHAAKSLAIIVGIFALCWLPVHILNcITLFQPEFSKSKPKWAMNVAIL---LSHANSVVNPIVYAY 285
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
52-339 1.57e-19

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 87.49  E-value: 1.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTE-TWYFGFAMCKIALFLQT 130
Cdd:cd15192    3 IPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADL-CFLITLPLWAAYTAMEyHWPFGNFLCKIASALVS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIVADlTRFVKRQYIDLlifCGPQWS 208
Cdd:cd15192   82 FNLYASVFLLTCLSIDRYLAIVHPMksRLRRTLVVARVTCIVIWLLAGVASLPAIIHRD-VFFIENTNITV---CAFHYP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQ--VVYQSVIIVLMYLLPLVLMTVTYSMIavvlWTGKIPGAIESANRPMMDgnvnraeeqlesrkKAAKMLITVVI 286
Cdd:cd15192  158 SQNSTllVGLGLMKNLLGFLIPFLIILTCYTLI----GKALKKAYEIQRNKPRND--------------EIFKMIMAVVL 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 287 GFAVCYFPVHLFNILRYADALRFVA----PRMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15192  220 FFFFCWIPHQIFTFLDVLIQLKVIQdchiADIVDTAMPFTICIAYFNSCLNPILYGF 276
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
50-340 1.58e-19

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 87.50  E-value: 1.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFL 128
Cdd:cd15193    1 IYIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADL-VFVLTLPFWAASTALgGQWLFGEGLCKLSSFI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 129 QTTSVAVSVFTLSAISVERWYAICYPLRFK--STKRRAKIIILVIWIIAFLLALPEVIVADLTRFVkrqyidlliFCgpq 206
Cdd:cd15193   80 IAVNRCSSILFLTGMSVDRYLAVVKLLDSRplRTRRCALITCCIIWAVSLVLGIPSLVYRNLINES---------VC--- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQVV--YQSVIIVLMYLLPLVLMTVTYSMIAVVLWTgkipgaiesanrpmmdgNVNRAEEQLESRKKAAKMLITV 284
Cdd:cd15193  148 VEDSSSRFFqgISLATLFLTFVLPLIVILFCYCSILVRLRR-----------------HFHGAKRTGRRRRNSLRIVFAI 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 285 VIGFAVCYFPVHLFNILRYadALRFVAPRMIQVLSMISHW-------LPYLNSSINPIIYNFM 340
Cdd:cd15193  211 VTAFVLSWLPFNTLKAVRL--LLELGGGVLPCHTTVAIRQgltitacLAFVNSCVNPLIYSLL 271
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
50-336 1.69e-19

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 87.60  E-value: 1.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15127    1 YAVMCLSVVIFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYA-----ICYPLRFKSTKRRAKiiILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCG 204
Cdd:cd15127   81 VASLGVTTFTLCALCIDRFRAatnvqMYYEMIENCTSTTAK--LAVIWVGALLLALPEVVLRQLSKEDGGSGAPPAERCV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 PQWSDKTNQVVYqsvIIVLMY-------------LLPlVLMTVTYSMIAvvlwTGKIPGAIESANRPmmdgnvNRAEEQL 271
Cdd:cd15127  159 VKISTELPDTIY---VLALTYdgarlwwyfgcyfCLP-TLFTITCSLVT----ARKIRRAEKACTRG------NKRQIQL 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 272 ESRKKAAKMLITVVIGFavCYFPVHLFNILRyADALRFVAPRMIQVLSMISHWLPYLNSSINPII 336
Cdd:cd15127  225 ESQMNCTVVALTILYGF--CIIPENICNIVT-AYMATGVSRQTMDLLHLISQFLLFFKSCVTPVL 286
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
56-344 1.75e-19

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 87.50  E-value: 1.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  56 YALTFIVGLSGNVLVCFA-VWRNRSMRTVTnIFIVNLAIADlAVIIICLPPTLLSDVTET-WYFGFAMCKIALFLQTTSV 133
Cdd:cd15373    7 YGIVFVVGLVLNILALYVfLFRTKPWNAST-TYMFNLAISD-TLYVLSLPLLVYYYADENdWPFSEALCKIVRFLFYTNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSDktNQ 213
Cdd:cd15373   85 YCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDTSSPELFD--QF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 VVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanRPMMDGNVNRAEEQlESRKKAAKMLITVVIGFAVCYF 293
Cdd:cd15373  163 VVYSSVMLVLLFCVPFVVILVCYALMV----------------RKLLKPSAGTSTNS-RSKKKSVKMIIIVLAVFILCFL 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 405966368 294 PVHLFNILRYADA---LRFVAPRMIQVLSMISHWLPYLNSSINPIIYnFMSVQT 344
Cdd:cd15373  226 PFHVTRTLYYSFRsmdLSCGTLNAINLAYKVTRPLASANSCLDPILY-FLAGQS 278
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
55-348 1.75e-19

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 87.31  E-value: 1.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIF---IVNLAIADLAVIIICLPPTLLSDV--TETWYFGFAMCKIALFLQ 129
Cdd:cd15130    6 IYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVryhLGSLALSDLLILLLAMPVELYNFIwvHHPWAFGDAGCRGYYFLR 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQW 207
Cdd:cd15130   86 DACTYATALNVASLSVERYLAICHPFKAKTlmSRSRTKKFISAIWLASALLAIPMLFTMGLQNESDDGTHPGGLVCTPIV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQsVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIG 287
Cdd:cd15130  166 DTATLKVVIQ-VNTFMSFLFPMLVTSILNTVIANKL---------------------------VQALRRGVLVLRAVVIA 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 288 FAVCYFPVHLFNILR-YADALRFVAP--RMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15130  218 FVVCWLPYHVRRLMFcYISDEQWTTFlfDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVF 281
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
51-339 2.30e-19

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 87.17  E-value: 2.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILyALTFIVGLSGNVLVCFAV--WRNRSMRTVTNIFIVNLAIADLAVIIicLPPTLLSDVT-ETWYFGFAMCKIALF 127
Cdd:cd15122    3 GTIFL-LLAALLGLPGNGFIIWSIlwKMKARGRSVTCILILNLAVADGAVLL--LTPFFITFLTrKTWPFGQAVCKAVYY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 128 LQTTSVAVSVFTLSAISVERWYAICYPLRFKSTKRR--AKIIILVIWIIAFLLALPEVIVADLtrfVKRQYIDLLIfCGP 205
Cdd:cd15122   80 LCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKalVRKILLAIWLLALLLALPAFVYRHV---WKDEGMNDRI-CEP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 QWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnrAEEQLESRKKAAKMLITVV 285
Cdd:cd15122  156 CHASRGHAIFHYTFETLVAFVLPFGVILFSYSVILVRL-----------------------KGARFRRRARVEKLIAAIV 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 286 IGFAVCYFPVHLFNILRYADALrfVAPRMIQVLSMISH-------WLPYLNSSINPIIYNF 339
Cdd:cd15122  213 VAFALLWVPYHVVNLLQVVANL--APGEVLEKLGGAAKaaragatALAFFSSSVNPLLYVF 271
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
55-348 2.81e-19

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 86.75  E-value: 2.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLavIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVA 134
Cdd:cd15173    6 MYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADL--LFLCTLPFWAYSAAHEWIFGTVMCKITNGLYTINLY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLRFKSTKRR----AKIIILVIWIIAFLLALPEVIVADLTRFVKRqyidlliFCGPQWSDK 210
Cdd:cd15173   84 SSMLILTCITVDRFIVIVQATKAHNCHAKkmrwGKVVCTLVWVISLLLSLPQFIYSEVRNLSSK-------ICSMVYPPD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgNVNraeeqlesRKKAAKMLITVVIGFAV 290
Cdd:cd15173  157 AIEVVVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAK---------------GFQ--------KHKSLKIIFVVVAVFIL 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 291 CYFPvhlFNILRYADALRFVAPRMIQVLS--MISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15173  214 TQLP---YNIMKLIRTLHIENTDSTNFKYaiLITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
51-348 3.27e-19

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 87.16  E-value: 3.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVW---RNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTE--TWYFGFAMCKIA 125
Cdd:cd15135    2 TLTLLYSLILVAGILGNSATIKVTQvlqKKGYLQKSVTDHMVSLACSDLLVLLLGMPVELYSAIWDpfATPSGNIACKIY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 126 LFLQTTSVAVSVFTLSAISVERWYAICYPLRFKS-TKRRAKIIILVIWIIAFLLALP--------EVIVADLTRFVKRQY 196
Cdd:cd15135   82 NFLFEACSYATILNVATLSFERYIAICHPFKYKAlSGSRVRLLICFVWLTSALVALPllfamgteDPLEAFPSYRGTRHH 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 197 IDL----LIFCGPQWSDKTnqvVYQSVII--VLMYLLPLVLMTVTYSMIAVVLwTGKIPGAIESANRPMMDGNVNRAE-- 268
Cdd:cd15135  162 CQDqksnLTICTSLSSKWT---VFQASIFsaFVLYLLVLASVAFMCRRMMRAL-MGSKKGAVAVKGPGGSVQLLRKHEsa 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 269 EQLESRKKAAKMLITVVIGFAVCYFPvhlFNILRYADALRfvaP---------RMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15135  238 EGKTARKQTILFLGLIVGTLAVCWMP---NQIRRIMAAAK---PkddwtrsyfRAYIILLPIADTFFYLSSVLNPLLYNL 311

                 ....*....
gi 405966368 340 MSVQTKGAF 348
Cdd:cd15135  312 SSQQFRSVF 320
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
50-339 3.31e-19

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 86.64  E-value: 3.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15312    1 VAMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLA----LPEVIVADLTRFVkrqyidLLIFC 203
Cdd:cd15312   81 MMLSTTSIFHLCFIAVDRYYAVCDPLHYrtKITTPVIKVFLVISWSVPCLFAfgvvFSEVNLEGIEDYV------ALVSC 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 GPQWSDKTNQVvYQSVIIVLMYLLPLVLMTVTYSMIAVVlwTGKIPGAIESANRPMMDGNVNRAEEQLEsrKKAAKMLIT 283
Cdd:cd15312  155 TGSCVLIFNKL-WGVIASLIAFFIPGTVMIGIYIKIFFV--ARKHAKVINNRPSVTKGDSKNKLSKKKE--RKAAKTLSI 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 284 VVIGFAVCYFPvhlFNILRYADA-LRFVAPRMIQVLSMishWLPYLNSSINPIIYNF 339
Cdd:cd15312  230 VMGVFLLCWLP---FFVATLIDPfLNFSTPVDLFDALV---WLGYFNSTCNPLIYGF 280
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
54-165 3.48e-19

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 86.43  E-value: 3.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15008    4 LVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTP 83
                         90       100       110
                 ....*....|....*....|....*....|..
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKSTKRRAK 165
Cdd:cd15008   84 GVQIYVLLSICVDRFYTIVYPLSFKVSREKAK 115
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
57-339 3.70e-19

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 86.75  E-value: 3.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  57 ALTFIVGLS--GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15212    6 VLLAIFLLSslGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSrPGWLFGDRLCLANGFFNACFG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPqWSDKTNQ 213
Cdd:cd15212   86 IVSTLTMTLISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYEKLGFYHCLYVLH-SGPSRLG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 VVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgKIPGAIESANRPMmdgNVNRAEEQLESRKKAAKMLITVVIGFAVCYF 293
Cdd:cd15212  165 AAYSSVLIVLCYLLPFALMCFCHYNIC------KTVRLSESRVRPV---TTYAHLLRFYSEMRTATTVLIMIVFIICCWG 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 405966368 294 PVHLFNILRYADALRFvAPRMIQVLSmishWLPYLNSSINPIIYNF 339
Cdd:cd15212  236 PYCLLGLVAAAGGYQF-PPLMDTVAI----WMAWANGAINPLIYAI 276
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
64-339 3.82e-19

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 86.98  E-value: 3.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  64 LSGNVLVCFAVWRNRSMRT-VTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGfAMCKIALFLQTTSVAVSVFTLSA 142
Cdd:cd15320   16 LLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 143 ISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVaDLTRFVKRQYIDLLIFCGPQWSDKTNQVVYQSVI 220
Cdd:cd15320   95 ISVDRYWAISSPFRYerKMTPKVAFIMISVAWTLSVLISFIPVQL-NWHKAKPTSFLDLNASLRDLTMDNCDSSLNRTYA 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 221 I---VLMYLLPLVLMTVTYSMIAVVLW------TGKIPGAIESANRPMMDGNVNRAE-EQLESR-----KKAAKML--IT 283
Cdd:cd15320  174 IsssLISFYIPVAIMIVTYTRIYRIAQkqirriSALERAAVHAKNCQNSTGNRGSGDcQQPESSfkmsfKRETKVLktLS 253
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 284 VVIG-FAVCYFPVHLFNILryadaLRFVAPRMIQVLSMISH------WLPYLNSSINPIIYNF 339
Cdd:cd15320  254 VIMGvFVCCWLPFFILNCM-----VPFCKPTSTEPFCISSTtfdvfvWFGWANSSLNPIIYAF 311
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
61-348 4.04e-19

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 86.00  E-value: 4.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVFTL 140
Cdd:cd15062   12 LFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 141 SAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAF------LLALPEVIVADLTrfvkrqyidlliFCGpqwsdKTN 212
Cdd:cd15062   92 CVISVDRYIGVRYPLNYPTivTARRATVALLIVWVLSLvisigpLLGWKEPAPADEQ------------ACG-----VNE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiesanrpmmdgnvnraeeQLESRKKAAKMLITVVIGFAVCY 292
Cdd:cd15062  155 EPGYVLFSSLGSFYLPLAIILVMYCRVYVVAF-------------------------KFSREKKAAKTLGIVVGAFVLCW 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 293 FPvhlFNILRYADALrFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15062  210 FP---FFVVLPLGSL-FSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
58-341 7.44e-19

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 85.67  E-value: 7.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSV 137
Cdd:cd15400    9 FTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 138 FTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAF--LLALPEVIVADLtRFVKRQYIDLLIfcgpqwsdKTNQVV 215
Cdd:cd15400   89 FNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALtvVAIVPNFFVGSL-EYDPRIYSCTFV--------QTASSS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 216 YQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgKIPGAIESANRPMMDgnvnraeeqlESRKKAAKMLITVVIGFAVCYFPV 295
Cdd:cd15400  160 YTIAVVVIHFIVPITVVSFCYLRIWVLVI--QVRRKVKSESKPRLK----------PSDFRNFLTMFVVFVIFAICWAPL 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 405966368 296 HLFNiLRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15400  228 NLIG-LAVAINPQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLN 272
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
53-348 7.90e-19

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 85.18  E-value: 7.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15060    4 TILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVAD--LTRFVKRQYIDLlifcgpqwS 208
Cdd:cd15060   84 CTASILNLCAIALDRYWAIHDPINYaqKRTLKRVLLMIVVVWALSALISVPPLIGWNdwPENFTETTPCTL--------T 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSviiVLMYLLPLVLMTVTYsmIAVVLWTGKipgaiesanrpmmdgnvnraeeqlesRKKAAKMLITVVIGF 288
Cdd:cd15060  156 EEKGYVIYSS---SGSFFIPLLIMTIVY--VKIFIATSK--------------------------ERRAARTLGIIMGVF 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPRMIQVLSmishWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15060  205 VVCWLPFFLMYVILPFCETCSPSAKVVNFIT----WLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
55-339 9.25e-19

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 86.16  E-value: 9.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRT-VTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGfAMCKIALFLQTTSV 133
Cdd:cd15319    6 LLSLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIV----ADLTRFVKRQYIDLLIFCGPQW 207
Cdd:cd15319   85 TASILNLCVISVDRYWAISSPFRYerKMTQRVALVMISVAWTLSVLISFIPVQLnwhkDSGDDWVGLHNSSISRQVEENC 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYlLPLVLMTVTYSMIAVVLWTG-KIPGAIESANRPMMDGNVNRAEEQLE-----SRKKAAKML 281
Cdd:cd15319  165 DSSLNRTYAISSSLISFY-IPVAIMIVTYTRIYRIAQIQiRRISSLERAAEHAQSCRSNRIDCHHHtslrtSIKKETKVL 243
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 282 --ITVVIG-FAVCYFPVHLFNIL-----RYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15319  244 ktLSVIMGvFVCCWLPFFILNCMvpfcdRPPADPDAGLPCVSETTFDVFVWFGWANSSLNPIIYAF 309
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
54-348 1.02e-18

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 84.97  E-value: 1.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLS--GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15321    9 IAAAITFLILFTifGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIvadlTRFVKRQYIDLLIFCgpQWSD 209
Cdd:cd15321   89 FCTSSIVHLCAISLDRYWSVSRAIEYnsKRTPRRIKCIILIVWLIAAVISLPPLI----YKGKQKDEQGGLPQC--KLNE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSviiVLMYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIG-F 288
Cdd:cd15321  163 EAWYILSSS---IGSFFAPCLIMILVYLRIYLI----------------------------AKNREKRFTFVLAVVIGvF 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 289 AVCYFPVHlfnilrYADALRFVAPRMIQV---LSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15321  212 VLCWFPFF------FSYSLGAICPELCKVphsLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
55-343 2.19e-18

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 84.42  E-value: 2.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLavIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVA 134
Cdd:cd15174    6 LYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADL--LFLCTLPFWATAASSGWVFGTFLCKVVNSMYKINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLRFKSTKRR----AKIIILVIWIIAFLLALPEVIvadltrFVKRQYIDLLIFCGPQWSDK 210
Cdd:cd15174   84 SCMLLLTCISVDRYIAIVQATKAHNSKNKrllySKLVCFFVWLLSTILSLPEIL------FSQSKEEESVTTCTMVYPSN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TN---QVVYQSVIIVLMYLLPLVLMTVTYSMIavvlwtgkIPGAIESANRpmmdgnvnraeeqleSRKKAAKMLITVVIG 287
Cdd:cd15174  158 ESnrfKVAVLALKVTVGFFLPFVVMVICYTLI--------IHTLLQAKRF---------------QKHKALKVIIAVVTV 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 288 FAVCYFPVHLFNILRYADALRFV-----APRMIQVLSMISHWLPYLNSSINPIIYNFMSVQ 343
Cdd:cd15174  215 FVLSQLPYNSILLIKTINAYNITitdcaTSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVR 275
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
50-348 2.28e-18

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 84.23  E-value: 2.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILyaLTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15307    3 WALLAL--VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPevivadLTRFVKRQYIDLLIfcgpqw 207
Cdd:cd15307   81 VLFCTASIMHLCTISVDRYLSLRYPMRFgrNKTRRRVTLKIVFVWLLSIAMSLP------LSLMYSKDHASVLV------ 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 sDKTNQV---VYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesANRPMMDGNVNRAEEqlesrkKAAKMLITV 284
Cdd:cd15307  149 -NGTCQIpdpVYKLVGSIVCFYIPLGVMLLTYCLTVRLL-----------ARQRSRHGRIIRLEQ------KATKVLGVV 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 285 VIGFAVCYFPVHLFNILRY--ADALRFVAPRMIQVLSmishWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15307  211 FFTFVILWSPFFVLNLLPTvcAECEERISHWVFDVVT----WLGYASSMVNPIFYTIFNKVFRQAF 272
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
52-348 3.22e-18

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 83.46  E-value: 3.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15322    3 LIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIvaDLTRFVKRQYIDLLIFCGPQWsd 209
Cdd:cd15322   83 FCTSSIVHLCAISLDRYWSITQAIEYnlKRTPRRIKCIIFIVWVISAVISFPPLI--TIEKKSGQPEGPICKINDEKW-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 ktnQVVYQSviiVLMYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIG-F 288
Cdd:cd15322  159 ---YIISSC---IGSFFAPCLIMVLVYIRIYQI----------------------------AKNREKRFTFVLAVVIGvF 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 289 AVCYFPvhLFNILRYADALRFVAPRmiqVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15322  205 VICWFP--FFFTYTLTAVCDCSVPE---TLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
61-337 4.03e-18

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 83.61  E-value: 4.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVFTL 140
Cdd:cd15336   12 ITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 141 SAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVivadltrFVKRQYID--LLIFCGPQWSDKTNQV-V 215
Cdd:cd15336   92 LAISLDRYLVITKPLASirWVSKKRAMIIILLVWLYSLAWSLPPL-------FGWSAYVPegLLTSCTWDYMTFTPSVrA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 216 YQSVIIVLMYLLPLVLMTVTY-SMIAVVLWTGKIPGAIESANRpmmdGNVNRAEEQLESRKKAAKMLITVVIGFAVCYFP 294
Cdd:cd15336  165 YTMLLFCFVFFIPLGIIIYCYlFIFLAIRSTGREVQKLGSQDR----KEKAKQYQRMKNEWKMAKIAFVVILLFVLSWSP 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 405966368 295 VHLFNILRYADALRFVAPRMIQVLSMISHwlpylNSSI-NPIIY 337
Cdd:cd15336  241 YACVALIAWAGYAHLLTPYMKSVPAVIAK-----ASAIyNPIIY 279
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
53-341 4.18e-18

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 83.71  E-value: 4.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15387    4 VTVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRfkSTKRRA-KIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPqWSDKT 211
Cdd:cd15387   84 MFASTYMLLLMSIDRCLAICQPLR--SLHRRSdRVYVLFSWLLSLVFSIPQVHIFSLREVGNGVYDCWADFIQP-WGPKA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 nqvvYQSVIIVLMYLLPLVLMTVTYSMIAVVLWT--------GKIPGAIESANRPMMDGNVNRAEEQLESRKKAAKMLIT 283
Cdd:cd15387  161 ----YITWITLSVYIIPVLILSVCYGLISFKIWQnvklktrrETKTPLSSAASGGAALARVSSVKLISKAKIRTVKMTFV 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 284 VVIGFAVCYFPVHLFNILRYADAlrfVAPR--MIQVLSMIshwLPYLNSSINPIIYNFMS 341
Cdd:cd15387  237 IVLAYIVCWTPFFFVQMWSVWDP---NAPKeaSPFIIAML---LASLNSCCNPWIYMFFT 290
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
53-341 4.60e-18

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 83.25  E-value: 4.60e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFaVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTE-TWYFGFAMCKIALFLQTT 131
Cdd:cd15119    4 IVIYIVAFVLGVPGNAIVIW-VTGFKWKKTVNTLWFLNLAIADF-VFVLFLPLHITYVALDfHWPFGVWLCKINSFVAVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPL---RFKSTKrRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIdllIFCGPQWS 208
Cdd:cd15119   82 NMFASVLFLTVISLDRYISLAHPVwshRYRTLK-SALILCGIVWLSAAAISGPALYFRDTMELSINVTI---CFNNFHKH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLM----YLLPLVLMTVTYSMIAVvlwtgkipgaiesanrpmmdgNVNRAEEQLESrkKAAKMLITV 284
Cdd:cd15119  158 DGDLIVMRHTILVWVRfffgFLFPLLTMVVCYSLLAI---------------------KVKRRTLLISS--KFFWTISAV 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 285 VIGFAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15119  215 IVAFFVCWTPYHIFSILELSIHHSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIG 271
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
52-348 5.46e-18

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 83.32  E-value: 5.46e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTV--TNIFIVNLAIADLavIIICLPPTLLSD--VTETWYFGFAMCKIALF 127
Cdd:cd14976    3 VSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQseSNKFVFNLALTDL--IFVLTLPFWAVEyaLDFVWPFGTAMCKVVRY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 128 LQTTSVAVSVFTLSAISVERWYAICYPLRFKSTK--RRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFcgP 205
Cdd:cd14976   81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRkaFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHTLCLLRF--P 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 QWSDKTNQV----VYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANrpmmdgnvnraeeqlesrkkAAKML 281
Cdd:cd14976  159 KNSSVTRWYnwlgMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSKRRKSR--------------------VTKSV 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 282 ITVVIGFAVCYFPVH---LFNILRYADALRF-VAPRMIQVLSM-ISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14976  219 FIVVLSFFICWLPNQalsLWSALIKFDDVPFsDAFFAFQTYAFpVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
62-341 6.80e-18

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 82.94  E-value: 6.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  62 VGLSGNVLVCFAVWRNRSmRTVTNIFIVNLAIADLAVIIIClpPTLLSDVTE--TWYFGFAMCKIALFLQTTSVAVSVFT 139
Cdd:cd15339   13 TGLVGNILVLFTIIRSRK-KTVPDIYVCNLAVADLVHIIVM--PFLIHQWARggEWVFGSPLCTIITSLDTCNQFACSAI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 140 LSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIA--FLLALPEVIVADLTRFVkrqyiDLLIFCGPQWSDKTNQVVYQ 217
Cdd:cd15339   90 MTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAasFILVLPVWVYAKVIKFR-----DGLESCAFNLTSPDDVLWYT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 218 SVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiESANRPMMDGNVNRAEEQLESRkKAAKMLITVVIGFAVCYFPVHL 297
Cdd:cd15339  165 LYQTITTFFFPLPLILICYILILCYTW--------EMYRKNKKAGRYNTSIPRQRVM-RLTKMVLVLVGVFLVSAAPYHV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 405966368 298 FNILRyadaLRFVAPRMIQVLSM-ISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15339  236 IQLVN----LSVSQPTLAFYVSYyLSICLSYASSSINPFLYILLS 276
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
64-348 1.13e-17

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 81.81  E-value: 1.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  64 LSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQTTSVAVSVFTLSA 142
Cdd:cd15308   15 IAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQgGVWTLSPVLCDALMTMDVMLCTASIFNLCA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 143 ISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIfcgpqwsDKTNQVVYQSVIiv 222
Cdd:cd15308   95 ISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRDPAVCKL-------EDNNYVVYSSVC-- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 223 lMYLLPLVLMTVTYSMiavvlwtgkipgaiesanrpMMDGnvnraeeqLESRKKAAKMLITVVIGFAVCYFPVHLFNILR 302
Cdd:cd15308  166 -SFFIPCPVMLVLYCA--------------------MFRG--------LGRERKAMRVLPVVVGAFLFCWTPFFVVHITR 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 405966368 303 YADALRFVAPRMIQVLSmishWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15308  217 ALCESCSIPPQLISIVT----WLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
54-348 1.23e-17

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 81.62  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15309    5 MLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFK---STKRRAKIIILVIWIIAFLLALPEVIVADLTRfvkrqyIDLLIFCGPQWsdk 210
Cdd:cd15309   85 TASILNLCAISIDRYTAVAMPMLYNtrySSKRRVTVMISVVWVLSFAISCPLLFGLNNTD------QNECIIANPAF--- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 tnqVVYQSVIivlMYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIGFAV 290
Cdd:cd15309  156 ---VVYSSIV---SFYVPFIVTLLVYVQIYIV----------------------------LQKEKKATQMLAIVLGVFII 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 291 CYFPVHLFNILRYADALRfVAPRMIQVLSmishWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15309  202 CWLPFFITHILNMHCDCN-IPPALYSAFT----WLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
57-348 1.67e-17

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 81.27  E-value: 1.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  57 ALTFIVGLS--GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVA 134
Cdd:cd15066    5 AMTLIILAAifGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIvadLTRFVKRQYIDLLIFCGPQWSDKTN 212
Cdd:cd15066   85 ASILHLCCISVDRYYAIVQPLEYpsKMTKRRVAIMLANVWISPALISFLPIF---LGWYTTEEHLQYRKTHPDQCEFVVN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QvVYQSVIIVLMYLLPLVLMTVTYSMIAVVlwtgkipgaiesANRpmmdgnvnraeeqlesRKKAAKMLITVVIGFAVCY 292
Cdd:cd15066  162 K-IYALISSSVSFWIPCIVMIFTYYRIYLE------------AKR----------------EHKAAKTLGIIMGAFILCW 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 293 FPVHLFNILRYADALRFVAPRmiqVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15066  213 LPFFLWYVTTTLCGDACPYPP---ILVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
50-339 2.36e-17

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 81.60  E-value: 2.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAV-IIICLPPTLLSDVTETWYFGFAMCKIALFL 128
Cdd:cd15337    1 YLIGIYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFsAVNGFPLKTISSFNKKWIWGKVACELYGFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 129 QTTSVAVSVFTLSAISVERWYAICYPLR--FKSTKRRAKIIILVIWIIAFLLALPEVIvaDLTRFVKRQY-----IDLLi 201
Cdd:cd15337   81 GGIFGFMSITTLAAISIDRYLVIAKPLEamKKMTFKRAFIMIIIIWLWSLLWSIPPFF--GWGRYVPEGFqtsctFDYL- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 202 fcgpqwSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIavvLWtgkipgAIESANRPMM----DGNVNRAEEQLESRK-- 275
Cdd:cd15337  158 ------SRDLNNRLFILGLFIFGFLCPLLIIIFCYVNI---IR------AVRNHEKEMTqtakSGMGKDTEKNDARKKae 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 276 -KAAKMLITVVIGFAVCYFP---VHLFNILRYADalrFVAPRMIQVLSMISHwlpylNSSI-NPIIYNF 339
Cdd:cd15337  223 iRIAKVAIILISLFLLSWTPyavVALLGQFGPAY---WITPYVSELPVMFAK-----ASAIyNPIIYAL 283
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
53-341 2.69e-17

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 81.36  E-value: 2.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15388    4 IAVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPL-RFKSTKRRAKIIILVIWIIAFLLALPEVIVadltrFVKRQYIDLLIFCGPQWSDKT 211
Cdd:cd15388   84 MFASSYMIVAMTFDRHQAICRPMvTFQKGRARWNGPVCVAWAISLILSLPQVFI-----FSKVEVAPGVYECWACFIEPW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVIIVLMYLLPLVLMTV----TYSMIAVVLWTGKIPGAIESANRPMMDGNVNRAEEQLESRKKAAKMLITVVIG 287
Cdd:cd15388  159 GLKAYVTWITLVVFVLPTLIITVcqvlIFKEIHINIYLKSQIIVAVVKKKQLLSSRASSVAEVSKAMIKTVKMTLVIVLV 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 405966368 288 FAVCYFPvhlFNILRYADALRFVAPRMIQVLSMIShWLPYLNSSINPIIYNFMS 341
Cdd:cd15388  239 YVLCWAP---FFLVQLWSVWDPKAPTEGATFTILM-LLASLNSCTNPWIYMAFS 288
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
52-348 3.93e-17

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 80.59  E-value: 3.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAViIICLPPTLLSDVTE-TWYFGFAMCKIALFLQT 130
Cdd:cd14988    3 LFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGV-VLTLPVWMLEVMLDyTWLWGSFLCKFTHYFYF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAI----CYPLRFKSTKRRAkiIILVIWIIAFLLALPEVIVADLTRFVKrqyiDLLIFCGPQ 206
Cdd:cd14988   82 ANMYSSIFFLTCLSVDRYLTLtsssPFWQQHQHRIRRA--LCAGIWVLSAIIPLPEVVHMQLLDGVE----PMCLFLAPF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVvlwtgkipgAIESANRPmmdgnvnraeeqlESRKKAAKMLITVVI 286
Cdd:cd14988  156 ETYDEWALAVSLLTLIIGFLIPFSIIAVFNVLTAR---------YIRTAGRP-------------ESRRHCLLIYAYILV 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 287 gFAVCYFPVHLFNILRYADALRFVAP-----------RMIQVLSMishwlpyLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14988  214 -FVVCWLPYHVTLLLLTLHGSHISLHcnlvhflyffyDVIDCFSL-------LHCVANPILYNFLSKSFRGKL 278
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
54-239 3.98e-17

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 80.70  E-value: 3.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15079    5 FIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDF-LMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPL-RFKSTKRRAKIIILVIWIIAFLLALPEVIVAdLTRFVKRQYidlLIFCGPQW-SDKT 211
Cdd:cd15079   84 IGSIWTNAAIAYDRYNVIVKPLnGNPLTRGKALLLILFIWLYALPWALLPLLFG-WGRYVPEGF---LTSCSFDYlTRDW 159
                        170       180
                 ....*....|....*....|....*...
gi 405966368 212 NQVVYQSVIIVLMYLLPLVLMTVTYSMI 239
Cdd:cd15079  160 NTRSFVATIFVFAYVIPLIIIIYCYSFI 187
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
53-341 5.13e-17

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 80.61  E-value: 5.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15386    4 IGVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLR-FKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQ-YIDLLIFCGPQWSDK 210
Cdd:cd15386   84 MFASTYMLIMMTVDRYIAVCHPLRtLQQPSRQAYLMIGATWLLSCILSLPQVFIFSLREVDQGSgVLDCWADFGFPWGAK 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TnqvvYQSVIIVLMYLLPLVLMTVTYSMIAVVLWT---GKIPGAIESA---NRPMMDGNVNRAEEQLESRKKAAKMLITV 284
Cdd:cd15386  164 A----YITWTTLSIFVLPVAILIVCYSLICYEICKnlkGKTQTSRSEGggwRTQGMPSRVSSVRTISRAKIRTVKMTFVI 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 285 VIGFAVC---YFPVHLFNILRYAdalrfvAPR--MIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15386  240 VLAYIACwapFFSVQMWSVWDEN------APDedSSDFAFTITMLLASLSSCCNPWIYMFFS 295
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
53-341 5.14e-17

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 80.55  E-value: 5.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVcfaVWRN--RSMRTVTNIFIVNLAIADLAVIIIcLPPTLLSDVT-ETWYFGFAMCKIALFLQ 129
Cdd:cd15117    4 LVIYSSAFVLGTLGNGLV---IWVTgfRMTRTVTTVCFLNLAVADFAFCLF-LPFSVVYTALgFHWPFGWFLCKLYSTLV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIvadltrFVKRQYIDLLIFC---- 203
Cdd:cd15117   80 VFNLFASVFLLTLISLDRCVSVLWPVwaRNHRTPARAALVAVGAWLLALALSGPHLV------FRDTRKENGCTHCylnf 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 --------GPQWSDKTNQVVYQSVII---VLMYLLPLVLMTVTYSMIAVVLWTGKIpgaiESANRPMmdgnvnraeeqle 272
Cdd:cd15117  154 dpwnetaeDPVLWLETVVQRLSAQVItrfVLGFLVPLVIIGGCYGLIAARLWREGW----VHSSRPF------------- 216
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 273 srkkaaKMLITVVIGFAVCYFPVHLFNILRYADAL--RFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15117  217 ------RVLTAVVAAFFLCWFPFHLVSLLELVVILnqKEDLNPLLILLLPLSSSLACVNSCLNPLLYVFVG 281
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
54-339 6.26e-17

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 80.29  E-value: 6.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQTTS 132
Cdd:cd15194    5 ILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDF-IFLVTLPLWVDKEVVlGPWRSGSFLCKGSSYIISVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRR--AKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDllifcgpQWSDK 210
Cdd:cd15194   84 MYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKhnAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCN-------EDAGT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTgkipgaiesanrpmmdgNVNRAEEQLESRKKAAKMLITVVIGFAV 290
Cdd:cd15194  157 PSKVIFSLVSLIVAFFLPLLSILTCYCTIIWKLCH-----------------HYQKSGKHQKKLRKSIKIVFIVVAAFVF 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 291 CYFPVHLFNILRYADALR---FVAPRMIQVLSM-ISHWLPYLNSSINPIIYNF 339
Cdd:cd15194  220 SWMPFNLFKALAIASGLQvevTCLPYTLAQLGMeVSAPLAFANSCANPFIYYF 272
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
53-340 7.15e-17

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 79.81  E-value: 7.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFaVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLL-SDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15116    4 MVIYSVVFVLGVLGNGLVIF-ITGFKMKKTVNTVWFLNLAVADF-LFTFFLPFSIAyTAMDFHWPFGRFMCKLNSFLLFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYI------DLLIFC 203
Cdd:cd15116   82 NMFTSVFLLTVISIDRCISVVFPVWSQNhrSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKIicfnnfSLSGDN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 GPQWSDKTNQVVYQSVII---VLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnrAEEQLESRKKAAKM 280
Cdd:cd15116  162 SSPEVNQLRNMRHQVMTItrfLLGFLIPFTIIICCYAAIVLKL-----------------------KRNRLAKSSKPFKI 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 281 LITVVIGFAVCYFPVHLFNILryaDALRFVAPRMIQVLSM-ISHWLPYLNSSINPIIYNFM 340
Cdd:cd15116  219 IAAVIVTFFLCWAPYHILNLL---EMEATRSPASVFKIGLpITSSLAFINSCLNPILYVFM 276
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
54-348 7.22e-17

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 79.78  E-value: 7.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIvglsGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15050    9 TISLITVI----LNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVAS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRqyIDLLIFCGPQWSDKT 211
Cdd:cd15050   85 TASIFSLFILCIDRYRSVQQPLKYlkYRTKTRASLMISGAWLLSFLWVIPILGWHHFARGGER--VVLEDKCETDFHDVT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 nqvVYQSVIIVLMYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnVNRaeeqlesRKKAAKMLITVVIGFAVC 291
Cdd:cd15050  163 ---WFKVLTAILNFYIPSLLMLWFYAKIFKA---------------------VNR-------ERKAAKQLGFIMAAFILC 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 292 YFPVH-LFNILRYADALRFvaprmiQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15050  212 WIPYFiLFMVIAFCKNCCN------ENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
54-344 8.12e-17

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 79.80  E-value: 8.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLavIIICLPPTLLSD--VTETWYFGFAMCKIALFLQTT 131
Cdd:cd16001    5 VTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADL--LYVCSLPLLIVNyaMRDRWPFGDFLCKLVRFLFYT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIvadltrFVKRQYIDLLIFCGPQWSD 209
Cdd:cd16001   83 NLYGSILFLTCISVHRFLGVCYPIRSLAyrTRRLAVIGSAATWILVVLQLLPTLV------YARTGSINNRTVCYDLTSP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 K--TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiesanRPMMDGNVNRAeeqleSRKKAAKMLITVVIG 287
Cdd:cd16001  157 DnfGNYFPYGMVLTVTGFLIPFLIILLCYCLMIKSLI------------RSEEAAGVGKA-----ARAKSIRTILLVCGL 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 288 FAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISH--WLPY--LNSSINPIIYnFMSVQT 344
Cdd:cd16001  220 FALCFVPFHITRTIYLFVRVYLVQDCPLLQFVSLAYkiWRPLvsFNSCINPLLY-FLSGDS 279
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
55-339 8.72e-17

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 79.79  E-value: 8.72e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTE-TWYFGFAMCKIALFLQTTSV 133
Cdd:cd15158    6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDL-LCVCTLPLRVVYYVHKgQWLFGDFLCRISSYALYVNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKS--TKRRAKII------ILVIWIIAFLLALPEVIVADLTRfvkrqyidllIFCGP 205
Cdd:cd15158   85 YCSIYFMTAMSFTRFLAIVFPVQNLNlvTVKKARIVcvgiwiFVTLTSSPFLMSGSHDTETNKTK----------CFEPP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 QWSDKTNQV-VYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTgkipgaiesanrpmmdgNVNRAEEQLESRKKAAKMLITV 284
Cdd:cd15158  155 QSNQQLTKLlVLNYISLVVGFIIPFLVILICYAMIIRTLLK-----------------NTMKARKQQSSRKKAIRMIIIV 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 285 VIGFAVCYFP------VHLFNILRYADALRFVapRMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15158  218 LLAFLVSFMPyhiqrtIHLHFLSRKDSTCEEV--LYMQKSVVITLCLAAANCCFDPLLYFF 276
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
52-343 1.10e-16

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 79.41  E-value: 1.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIcLPPTLLSDVTeTWYFGFAMCKIALFLQTT 131
Cdd:cd15181    3 IPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLT-FPFSVVESIA-GWVFGTFLCKLVGAIHKL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLR-FKSTKRRA-KIIILVIWIIAFLLALPEVIVADLTrfvKRQYIDLLIFCGPQWSD 209
Cdd:cd15181   81 NFYCSSLLLACISVDRYLAIVHAIHsYRHRRLRSvHLTCGSIWLVCFLLSLPNLVFLEVE---TSTNANRTSCSFHQYGI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVII--VLMYLLPLVLMTVTYSMIAVVLwtgkipgaIESANRPmmdgnvnraeeqleSRKKAAKMLITVVIG 287
Cdd:cd15181  158 HESNWWLTSRFLyhVVGFFLPLLIMGYCYATIVVTL--------CQSSRRL--------------QKQKAIRVAILVTLV 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 288 FAVCYFPVHLFNILRYADALRFVAP-----RMIQVLSMISHWLPYLNSSINPIIYNFMSVQ 343
Cdd:cd15181  216 FCLCWLPYNIVIFLDTLDDLKAVVKncklnDLLDAAITVTESLGFSHCCLNPILYAFIGVK 276
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
52-340 1.22e-16

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 79.04  E-value: 1.22e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFaVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTET-WYFGFAMCKIALFLQT 130
Cdd:cd15115    3 SLVVLSLTFLLGVPGNGLVIW-VAGLKMKRTVNTIWFLNLAVADL-LCCLSLPFSIAHLLLNGhWPYGRFLCKLLPSIIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVadltrfvKRQYIDLLI-FCGPQW 207
Cdd:cd15115   81 LNMFASVFTLTAISLDRFLLVIKPVWAQNhrSVLLACLLCGCIWILALLLCLPVFIY-------RTTVTDGNHtRCGYDF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SdktnqVVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanRPMMDGNVNRaeeqleSRKKAAKMLITVVIG 287
Cdd:cd15115  154 L-----VAITITRAVFGFLLPLLIIAACYSFIA----------------FRMQRGRFAK------SQSKTFRVIIAVVVA 206
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 288 FAVCYFPVHLFNILRyadalRFVAPRMIQVLSMISHW---LPYLNSSINPIIYNFM 340
Cdd:cd15115  207 FFVCWAPYHIIGILS-----LYGDPPLSKVLMSWDHLsiaLAYANSCLNPVLYVFM 257
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
54-348 1.45e-16

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 79.06  E-value: 1.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15296    5 VLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLLC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKSTK---RRAKIIILVIWIIAFLLALPEVIVADltrFVKRQYIdllIFCGPQWSDK 210
Cdd:cd15296   85 TASVFNIVLISYDRFLSVTRAVSYRAQKgmtRQAVLKMVLVWVLAFLLYGPAIISWE---YIAGGSI---IPEGECYAEF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVlmTVTYSMIAVVLwtgkipgaiesanrpmmdgNVNRAEEQLESRKKAAKMLITVVIGFAV 290
Cdd:cd15296  159 FYNWYFLMTASTLEFFTPFI--SVTYFNLSIYL-------------------NIQKRRFRLSRDKKVAKSLAIIVCVFGL 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 291 CYFPVHLFNILRYADALRFVAprmiQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15296  218 CWAPYTLLMIIRAACHGHCVP----DYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
54-348 1.76e-16

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 78.48  E-value: 1.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15330    5 LFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVADLTRfvKRQYIDLLIFcgpqwSDKT 211
Cdd:cd15330   85 TSSILHLCAIALDRYWAITDPIDYvnKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPE--DRSDPDACTI-----SKDP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSviiVLMYLLPLVLMTVTYSMIavvlwtgkipgaIESANRpmmdgnvnraeeqlesRKKAAKMLITVVIGFAVC 291
Cdd:cd15330  158 GYTIYST---FGAFYIPLILMLVLYGRI------------FKAAAR----------------ERKTVKTLGIIMGTFILC 206
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 292 YFPVHLFNILryadaLRFVAPR--MIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15330  207 WLPFFIVALV-----LPFCESTchMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
55-341 1.89e-16

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 78.76  E-value: 1.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLavIIICLPPTLLSDVTET--WYFGFAMCKIALFLQTTS 132
Cdd:cd15379    6 VYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADL--LYVCSLPLLIYNYTQKdyWPFGDFTCRLVRFQFYTN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLA---LPEVIVADLTrfVKRQYIDLLIFCGPQWSd 209
Cdd:cd15379   84 LHGSILFLTCISVQRYLGICHPLASWHKKKGKKLTWLVCGAVWLVVIaqcLPTFVFASTG--TQRNRTVCYDLSPPARS- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 kTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeeqlESRKKAAKMLITVVIGFA 289
Cdd:cd15379  161 -TAYFPYGITLTRTGFLLPFAARLACYCSMATILCRVVIAVAVVAAPG--------------EKRGKAARMIIVVAAVFL 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 290 VCYFPVHL----FNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15379  226 ISFLPFHYtktrYLQVRSWDGGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQ 281
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
54-337 2.60e-16

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 78.74  E-value: 2.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15403    5 IVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWFFV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERwYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRqyidllifcGPQ----WSD 209
Cdd:cd15403   85 LEGVAILLIISVDR-FLIIVQRQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEVPAR---------APQcvlgYTE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMI--AVVLWTGKIPGAIESAN-RPMMDGNVNRAEEQ------LESRKKAAKM 280
Cdd:cd15403  155 SPADRVYAVLLVVAVFFVPFSIMLYSYLCIlnTVRRNAVRIHNHADSLClSQVSKLGLMGLQRPhqmnvdMSFKTRAFTT 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 281 LITVVIGFAVCYFPVHLFNILRYAdALRFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15403  235 ILILFVGFSLCWLPHTVFSLLSVF-SRRFYYSSSFYPISTCVLWLSYLKSVFNPVIY 290
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
55-337 5.09e-16

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 77.64  E-value: 5.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTET-WYFGFAMCKIALFLQTTSV 133
Cdd:cd15377    6 VYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADF-LYVLTLPALIFYYFNKTdWIFGDAMCKLQRFIFHVNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLR-FKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDllifCGPQWSDK-- 210
Cdd:cd15377   85 YGSILFLTCISVHRYTGVVHPLKsLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTIT----CYDTTSDEyl 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESaNRPMmdgnvnraeeqlesRKKAAKMLITVVIGFAV 290
Cdd:cd15377  161 RSYFIYSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYTEEN-NAPL--------------RRKSIYLVIIVLTVFAV 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 291 CYFPVHLFNILRYADALRFVAPRM------IQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15377  226 SYLPFHVMKTLNLRARLDFQTPAMcafndrVYATYQVTRGLASLNSCVDPILY 278
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
50-348 5.30e-16

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 77.44  E-value: 5.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRnRSMRTVTNIFIVNLAIADLaviIICLP-PTLLSDVTET--WYFGFAMCKIAL 126
Cdd:cd15114    1 VVALVLYAVVFLVGVPGNALVAWVTGF-EAKRSVNAVWFLNLAVADL---LCCLSlPILAVPIAQDghWPFGAAACKLLP 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPlRFKSTKRRAkIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQ 206
Cdd:cd15114   77 SLILLNMYASVLLLTAISADRCLLVLRP-VWCQNHRRA-RLAWIACGAAWLLALLLTVPSFIYRRIHQEHFPEKTVCVVD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WS-DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTgkipgaiesanrpmmdgnvnraeEQLESRKKAAKMLITVV 285
Cdd:cd15114  155 YGgSTGVEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWS-----------------------RRRQKSRRTLKVVTAVV 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 286 IGFAVCYFPVHLFN-ILRYADALRFVAPRMIQVLSMISHwLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15114  212 VGFFLCWTPYHVVGlIIAASAPNSRLLANALKADPLTVS-LAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
54-341 5.89e-16

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 77.32  E-value: 5.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15074    5 IYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYP-LRFKSTKRRAKIIILVIWIIAFLLALPEviVADLTRFVKRQYidlLIFCGPQW---SD 209
Cdd:cd15074   85 CCSINTLTAISIYRYLKICHPpYGPKLSRRHVCIVIVAIWLYALFWAVAP--LVGWGSYGPEPF---GTSCSIDWtgaSA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVvlwtgKIPGAiesanRPMMDGNVNRAEEQLESRKKAAKMLITVVIGFA 289
Cdd:cd15074  160 SVGGMSYIISIFIFCYLLPVLIIVFSYVKIIR-----KVKSS-----RKRVAGFDSRSKRQHKIERKVTKVAVLICAGFL 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 290 VCYFP---VHLFNIlryadalrFVAPRMIQVLSMIshwLPYL----NSSINPIIYNFMS 341
Cdd:cd15074  230 IAWTPyavVSMWSA--------FGSPDSVPILASI---LPALfaksSCMYNPIIYLLFS 277
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
52-340 6.03e-16

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 77.24  E-value: 6.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAV-----WRNRSMrtvtNIFIVNLAIADLAvIIICLPPTLLSDVTE-TWYFGFAMCKIA 125
Cdd:cd15926    3 ISIVYSVVCALGLVGNLLVLYLMkskqgWKKSSI----NLFVTSLAVTDFQ-FVLTLPFWAVENALDfTWLFGKAMCKIV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 126 LFLQTTSVAVSVFTLSAISVERWYAICYPLRFKSTKRR--AKIIILVIWIIAFLLALPEVIVADlTRFVKRQYIDLLIFC 203
Cdd:cd15926   78 SYVTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCcsAKWLCVLIWVLAILASLPNAIFST-TATVSNEELCLVKFP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 GPQWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanRPMMDGNVNRAEEQleSRKKAAKMLIT 283
Cdd:cd15926  157 DNRGNAQFWLGLYHAQKVLLGFLIPLGIISLCYLLLV----------------RFITDKNITGSSTK--RRSKVTKSVTI 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 284 VVIGFAVCYFP---VHLFNILRYADALRFVAPRMI-QVLSM-ISHWLPYLNSSINPIIYNFM 340
Cdd:cd15926  219 VVLSFFLCWLPnqaLTTWGILIKLNVVHFSYEYFTtQVYIFpITVCLAHSNSCLNPILYCLM 280
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
51-337 6.36e-16

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 77.60  E-value: 6.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15957    2 GMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLA-LPevIVADLTRFVKRQYIDllIFCGPQW 207
Cdd:cd15957   82 LCVTASIETLCVIAVDRYFAITSPFKYQSllTKNKARVIILMVWIVSGLTSfLP--IQMHWYRATHQEAIN--CYAEETC 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SD-KTNQVVYQSVIIVLMYlLPLVLMTVTYSMI---------AVVLWTGKIPGAIESANRPMMDGNVNRAEEQLESRKKA 277
Cdd:cd15957  158 CDfFTNQAYAIASSIVSFY-VPLVIMVFVYSRVfqeakrqlqKIDKSEGRFHNQNIDQNGSGGGGGNRRRSKFCLKEHKA 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 278 AKMLITVVIGFAVCYFPVHLFNILRYADalRFVAPRMIQVLsmiSHWLPYLNSSINPIIY 337
Cdd:cd15957  237 LKTLGIIMGTFTLCWLPFFIVNIVHVIQ--DNLIRKEVYIL---LNWIGYVNSGFNPLIY 291
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
54-348 6.54e-16

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 77.04  E-value: 6.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFA-VWRNRSMRTVTnIFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQTT 131
Cdd:cd15375    5 VMYSIIFIVGFPGNIIAIFVyLFKMRPWKSST-IIMLNLALTDL-LYVTSLPFLIYYYINgESWIFGEFMCKFIRFIFHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRakIIILVIWIIAFLLALPEVI-----VADLTRFVKRQYIDLlifcgpQ 206
Cdd:cd15375   83 NLYGSILFLTCFSIFRYVVIVHPLRAFQVQKR--RWAIVACAVVWVISLAEVSpmtflITTKEKNNRTICLDF------T 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQV-VYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGkipgaiesanrPMMDGNvnraeeqleSRKKAAKMLITVV 285
Cdd:cd15375  155 SSDNLNTIwWYNWILTVLGFLLPLVIVTLCYTRIIYTLAKG-----------PHTGSA---------SKQKARRLIILIL 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 286 IGFAVCYFPVHLFNILRYADALRFVAP---RMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15375  215 LVFYVCFLPFHILRVVRIETRLPPVSCclkHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
56-343 6.65e-16

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 77.12  E-value: 6.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  56 YALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIClpPTLLSDVTETWYFGFAMCKIALFLQTTSVAV 135
Cdd:cd15177    7 YLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTL--PFAAAETLQGWIFGNAMCKLIQGLYAINFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 136 SVFTLSAISVERWYAI-CYPL---RFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFvKRQYIDLLIFcgPQWSDKT 211
Cdd:cd15177   85 GFLFLTCISVDRYVVIvRATSahrLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENR-SELSSCRMIF--PEVVSRT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPgaiesanrpmmdgnvnraeeqleSRKKAAKMLITVVIGFAVC 291
Cdd:cd15177  162 VKGATALTQVVLGFAIPLIVMAVCYAAIGRTLLAARGW-----------------------ERHRALRVIAALVVAFVLF 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 292 YFPVHLFNILRYADALRFVAP-----RMIQVLSMISHWLPYLNSSINPIIYNFMSVQ 343
Cdd:cd15177  219 QLPYSVVLLLDTADLLATLELscsqsKRKDIALLVTSGLAYVRCCLNPLLYAFVGVR 275
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
54-345 1.02e-15

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 76.73  E-value: 1.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTEtWYFGFAMCKIALFLQTTSV 133
Cdd:cd15179    5 TVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADL-LFVLTLPFWAVDAAAN-WYFGNFLCKAVHVIYTVNL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLrfKSTKRRA----KIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIfcgPQWSD 209
Cdd:cd15179   83 YSSVLILAFISLDRYLAIVHAT--NSQRPRKllaeKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIY---PEDTF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIGFA 289
Cdd:cd15179  158 ELWVVAFRFQHILVGLVLPGLVILTCYCIIISKLSHSK-----------------------GHQKRKALKTTVILILAFF 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 290 VCYFPVHLFNILRYADALRFVAPR-----MIQVLSMISHWLPYLNSSINPIIYNFMSVQTK 345
Cdd:cd15179  215 ACWLPYYIGISIDTFMLLEIIKQScemeqTVHKWISITEALAFFHCCLNPILYAFLGAKFK 275
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
54-345 1.06e-15

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 76.72  E-value: 1.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQTTS 132
Cdd:cd15162    5 AVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADL-LLVIWLPFKIAYHIHgNNWIFGEALCRLVTVAFYGN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPeVIVADLTRFVKRQYIDLLIFCGPQWSDK 210
Cdd:cd15162   84 MYCSILLLTCISIDRYLAIVHPMGHRRlrARRYALGTCLAIWLLALLVTLP-LYLVKQTIFLPALDITTCHDVLPEQLLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkIPGAIESANRpmmdgnvnraeeqleSRKKAAKMLITVVIGFAV 290
Cdd:cd15162  163 GDWFYYFLSLAIVGFLIPFILTASCYVATIRTL----AALEDENSEK---------------KKKRAIKLAATVLAIFII 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 291 CYFPVHLFNILRYADaLRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTK 345
Cdd:cd15162  224 CFAPSNLLLLAHYSL-ISSSGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
55-341 1.26e-15

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 76.33  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPptLLSDV---TETWYFGFAMCKIALFLQTT 131
Cdd:cd14991    6 LLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADF-LLLICLP--FRIDYylrGEHWIFGEAWCRVNLFMLSV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYP-LRF-KSTKRRAKIIILVIWIIAFLLALPEVivadLTRFVKRQYIDLLIFCGPQWSD 209
Cdd:cd14991   83 NRSASIAFLTAVALDRYFKVVHPhHRVnRMSVKAAAGVAGLLWALVLLLTLPLL----LSTLLTVNSNKSSCHSFSSYTK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTysmIAVVLWTGKIPGAIESANRPmmdgnvnraeeqlesrKKAAKMLITVVIGFA 289
Cdd:cd14991  159 PSLSIRWHNALFLLEFFLPLGLIVFC---SVRIACNLRIRQSLGKQARV----------------QRAIRLVFLVVIVFV 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 290 VCYFP-------VHLFNILRYADALRFVAprmiqVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd14991  220 LCFLPsiiagllALVFKNLGSCRCLNSVA-----QLFHISLAFTYLNSALDPVIYCFSS 273
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
57-339 1.28e-15

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 76.44  E-value: 1.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  57 ALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVS 136
Cdd:cd15318    8 AIGMLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 137 VFTLSAISVERWYAICYPLRF--KSTKRRAKIIILV----IWIIAFLLALPEVIVADLTRFVkrQYIDLLIFCgpqwsdk 210
Cdd:cd15318   88 IFHLCFISIDRHCAICDPLLYpsKFTIRVACIFIAAgwlvPTVYTSVFLYTKAVEEGLAELL--TSVPCVGSC------- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 tnQVVYQSVIIVL---MYLLPLVLMTVTYSMIAVVlwTGKIPGAIESANRpmmdgNVNRAEeqlESRKKAAKMLITVVIG 287
Cdd:cd15318  159 --QLLYNKLWGWLnfpVFFIPCLIMIGLYVKIFIV--AKRQARAIASLLS-----DTNGAS---KRERKAAKTLGIAVGV 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 288 FAVCYFPvhlFNILRYADA-LRFVAPrmiQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15318  227 YLLCWLP---FTIDTMVDSlLNFITP---PLLFDIIIWFAYFNSACNPLIYVF 273
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
54-339 1.40e-15

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 76.30  E-value: 1.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLV--CFAVWRNRSMRTVtnIFIVNLAIADLAVIIiCLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15152    5 VTYTVILIPGLIGNVLAlwVFYAYVKETKRAV--IFMINLAIADLLQVL-SLPLRIFYYLNKSWPFGKFLCMFCFYLKYV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLA---LPEVIVADLTRFvKRQYIDLLIfcgpQWS 208
Cdd:cd15152   82 NMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAGWLVVCVGclpFPLLRQSQDTNP-TCCFADLPL----RNV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLmtvtysmiaVVLWTGKIPGAIESANRPMMDgnvnraeeqLESRKKAAKMLITVVIGF 288
Cdd:cd15152  157 GLTTSVIMLTIAELTGFVTPLLI---------VLYCSWKTVMSLREKTPVLQD---------LGEKKKALKMILTCAVVF 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 289 AVCYFPVHLFNILRYADALRFV----APRMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15152  219 LICFAPYHISFPLDFLVKSNKIksctARKVILIFHPVALCLASLNSCLDPVIYYF 273
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
53-341 1.44e-15

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 76.06  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIF---IVNLAIADLAVIIICLPPTLLSDV--TETWYFGFAMCKIALF 127
Cdd:cd15356    4 TAVYALIWALGAAGNALTIHLVLKKRSLRGLQGTVhyhLVSLALSDLLILLISVPIELYNFVwfHYPWVFGDLVCRGYYF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 128 LQTTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPevivadlTRFVKRQYIDLL----- 200
Cdd:cd15356   84 VRDICSYATVLNIASLSAERYLAICQPLRAKRllSKRRTKWLLALIWASSLGFALP-------MAFIMGQKYELEtadge 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 201 -----IFCGPQWSDKTNQVVYQsVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnraeeQLESRK 275
Cdd:cd15356  157 pepssRVCTVLVSRATLKVFIQ-VNAFVSFVLPLALIAFLNGVTVSHL--------------------------RIQSLQ 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 276 KAAKMLITVVIGFAVCYFPVHLFNIL-------RYADALRfvapRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15356  210 HSVQVLRAIVIAYVICWLPYHARRLMfcyvpddAWTDSLY----NFYHYFYMLTNTLFYVSSAVNPLLYNVVS 278
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
54-348 1.47e-15

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 76.11  E-value: 1.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15155    5 AVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDL-LFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPlrFKSTKRRAKIIILVIWIIAFLLALPEVIVADLtrFVKRQYIDLLIFCGPQWSDKTNQ 213
Cdd:cd15155   84 YGSMLFLTCISVDRFLAIVYP--FRSRTIRTRRNSAIVCAGVWILVLSGGISASL--FSTTNVSNTSTTCFEGFSKSIWK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 VVYQSVII---VLMYLLPLVLMTVTYSmiaVVLWTGKIPGAIESANrpmmdgnvnraeeqlESRKKAAKMLITVVIGFAV 290
Cdd:cd15155  160 TYLSKITIfieVVGFIIPLLLNLTCSS---LVLRTLRKPATLSQIG---------------TNKEKVLKMILVHVAIFVV 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 291 CYFP----VHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15155  222 CFVPynsiLFLYALVRSQAIANCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
53-348 1.95e-15

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 76.04  E-value: 1.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDV-TETWYFGFAMCKIALFLQTT 131
Cdd:cd15071    4 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIgPQTEFYSCLMVACPVLILTQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SvavSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSD 209
Cdd:cd15071   84 S---SILALLAIAVDRYLRVKIPTRYKSvvTPRRAAVAIAGCWILSFLVGLTPMFGWNNLNAVERAWAANSSMGELVIKC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMY----LLPLVLMTVTYSMIAVVlwtgkipgaIESANRPMMDGNVNRAEEQLESRKKAAKMLITVV 285
Cdd:cd15071  161 QFETVISMEYMVYFNFfvwvLPPLLLMLLIYLEVFYL---------IRKQLNKKVSSSSSDPQKYYGKELKIAKSLALIL 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 286 IGFAVCYFPVHLFNILryadALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15071  232 FLFALSWLPLHILNCI----TLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
52-340 2.25e-15

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 75.68  E-value: 2.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVwRNRSMRTVT--NIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15925    3 VALAYGLVCAIGLLGNLAVMYLL-RNCARRAPPpiDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTAT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLR--FKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQyIDLLIFCGPQW 207
Cdd:cd15925   82 VLNVYASVFLLTAMSVTRYWVVASAAGpgTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVE-LCLLKFPSNYW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDktnqvVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIpgaieSANRPMMDGNVNRAeeqlesrkkaakmLITVVIG 287
Cdd:cd15925  161 LG-----AYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKV-----NQNNRQRQSVIARS-------------VRLVVAS 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 288 FAVCYFPVHL---------FNILRYADALRFVAPRMIQVLSMISHwlpyLNSSINPIIYNFM 340
Cdd:cd15925  218 FFLCWFPNHVvtfwgvlvkFRAVPWNSTFYFIHTYVFPVTTCLAH----SNSCLNPVLYCLM 275
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
52-348 2.63e-15

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 75.00  E-value: 2.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15297    3 IVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEV-----IVADLTRFVKRQYIDLLifcg 204
Cdd:cd15297   83 VSNASVMNLLIISFDRYFCVTKPLTYpvKRTTKMAGMMIAAAWVLSFILWAPAIlfwqfIVGGRTVPEGECYIQFF---- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 pqwsdkTNQVVYQSVIIVLMYlLPLVLMTVTYsmiavvlWtgkipgaiesanrpmmdgNVNRAEEQlesRKKAAKMLITV 284
Cdd:cd15297  159 ------SNAAVTFGTAIAAFY-LPVIIMTVLY-------W------------------QISRASSR---EKKVTRTILAI 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 285 VIGFAVCYFPvhlFNILRYADAlrFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15297  204 LLAFIITWTP---YNVMVLINT--FCASCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
52-348 2.74e-15

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 74.91  E-value: 2.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15324    3 IVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVAdltrfvKRQYIDLLIfcgpqwsd 209
Cdd:cd15324   83 FCTSSIVHLCAISLDRYWSVTKAVSYnlKRTPKRIKRMIAVVWVISAVISFPPLLMT------KHDEWECLL-------- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 kTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIG-F 288
Cdd:cd15324  149 -NDETWYILSSCTVSFFAPGLIMILVYCKIYRV----------------------------AKMREKRFTFVLAVVMGvF 199
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPrmiQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15324  200 VLCWFPFFFTYSLHAVCRKRCGIP---DALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
53-341 2.97e-15

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 75.11  E-value: 2.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLavIIICLPPTLLSDVT--ETWYFGFAMCKIALFLQT 130
Cdd:cd15160    4 PVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDL--LYILTLPLWIDYTAnhHNWTFGPLSCKVVGFFFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLlifCGPQWSDK 210
Cdd:cd15160   82 TNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDEPNHTL---CYEKYPME 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnRAEEQLESRKKAA--KMLITVVIGF 288
Cdd:cd15160  159 GWQASYNYARFLVGFLIPLSLILFFYRRVLRAV----------------------RQSPSLEREEKRKiiGLLLSIVVIF 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 289 AVCYFPVHLFNILRYadALRFVAPRM------IQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15160  217 LLCFLPYHVVLLVRS--VIELVQNGLcgfekrVFTAYQISLCLTSLNCVADPILYIFVT 273
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
54-340 3.50e-15

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 75.14  E-value: 3.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLV------CFAVWRNrsmrtvTNIFIVNLAIADLAviIIC-LPPTLLSDVTETWYFGFAMCKIAL 126
Cdd:cd15378    5 TMYSIEFVLGFIGNTIVilgyifCLKNWKS------SNIYLFNLSVSDLA--FLCtLPMLVYSYSNGQWLFGDFLCKSNR 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRakIIILVIWIIAFLLALPEVIvaDLTRFVKRQYIDLLIFCGPQ 206
Cdd:cd15378   77 YLLHANLYSSILFLTFISIDRYLLIKYPFREHILQKK--RSAVAISLAIWVLVTLELL--PILTFIGPNLKDNVTKCKDY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WS--DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdGNVNRAEEQLESRKKAAKMLITV 284
Cdd:cd15378  153 ASsgDATNSLIYSLFLTVTGFLIPLCVMCFFYYKIALFL------------------KNRNRQLANATSFEKPLTLVILA 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 285 VIGFAVCYFPVHLFNILRYADALRF--VAP---RMIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15378  215 VVIFSVLFTPYHVMRNVRIASRLDSigVSEctlIIIKSLYIVTRPIAFLNSVINPVFYFLM 275
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
54-341 3.55e-15

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 74.82  E-value: 3.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRN-RSMRTVTNIFIVNLAIADLaVIIICLPPTLLSdVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15188    5 VFYTLVFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDL-LFLVTLPFWAMY-VAWHWVFGSFLCKFVSTLYTIN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICY--PLRFKSTKRRAKIIILVIWIIAFLLALPEVIvadltrFVK-RQYIDLLIFCGPQWSD 209
Cdd:cd15188   83 FYSGIFFVSCMSLDKYLEIVHaqSPHRLRTRRKSLLVLVAVWVLSIALSVPDMV------FVQtHHTNNGVWVCHADYGG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTN--QVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGaiesanrpmmdgnvnraeeqlesRKKAAKMLITVVIG 287
Cdd:cd15188  157 HHTiwKLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPG-----------------------QGRALRFVAALVVV 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 288 FAVCYFPVHLFNILRYADALRFVA----PRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15188  214 FFVLWFPYNLTLFLHSLQDLHVIGncerSRHLDYALQVTESLAFVHCCLNPLLYAFVS 271
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
54-337 3.71e-15

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 75.22  E-value: 3.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIClpPTLLSDVTE--TWYFGFAMCKIALFLQTT 131
Cdd:cd15374    5 VSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSL--PTLIYYYADhnHWPFGVVACKIVRFLFYA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRfksTKRRAKIIILVIWIIAFLLALPEVIVADLTrFVKRQYIDLLIFCGPQWS--D 209
Cdd:cd15374   83 NLYCSILFLTCISVHRYVGICHPIR---ALRWVKPRHAYLICASVWLVVTVCLVPNLI-FVTTSRKDNITLCHDTTRpeE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiesanRPMMDGNVNRaeeQLESRKKAAKMLITVVIGFA 289
Cdd:cd15374  159 FDHYVHYSSAVMVLLFGIPCLVIVVCYGLMARRLC------------KPRVGSSRQQ---GPSSKKRSLKTIIMVLTVFA 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 405966368 290 VCYFPVHLFNILRYADALRFVAPRMIQVLSM---ISHWLPYLNSSINPIIY 337
Cdd:cd15374  224 ICFVPFHITRTLYYVARLLKADCDTLNIINVtykVTRPLASANSCLDPILY 274
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
53-341 4.52e-15

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 74.86  E-value: 4.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15385    4 IAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLR-FKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRF--VKRQYIDLLIFCGPqWSD 209
Cdd:cd15385   84 MFASTYMLVMMTADRYIAICHPLKtLQQPTKRSYLMIGSAWALSFILSTPQYFIFSLSEIenGSGVYDCWANFIVP-WGI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTnqvvYQSVIIVLMYLLPLVLMTVTYSMIAVVLW---TGKIPGAIESANRPMMDGNVNRAEEQLESRKK--AAKMLITV 284
Cdd:cd15385  163 KA----YITWITISIFVVPVIILLTCYGFICYNIWrniKCKTRRGLSDNALKNILLAVCVSSVKTISRAKirTVKMTFVI 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 285 VIGFAVCYFPVHLFNILRYADAlRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15385  239 VLAYIVCWAPFFTIQMWSVWDQ-NFPWDESENTAVTITALLASLNSCCNPWIYMFFS 294
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
52-341 5.24e-15

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 74.73  E-value: 5.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQT 130
Cdd:cd15148    3 LAVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADL-LLIICLPFRILYHVNnNQWTLGPLLCKVVGNLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWyaicypLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGpQWSDK 210
Cdd:cd15148   82 MNMYISIILLGFISLDRY------LKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIVLTEKNEESTKCF-QYKDR 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQV--VYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGkipgaieSANRPMMDGNVNRAeeqlesrkKAAKMLITVVIGF 288
Cdd:cd15148  155 KNAKgkAIFNFLIVAMFWLVFLLLILSYGKIAKKLLRI-------SRDKPDFPNAAKYN--------RTARKSFFVLFIF 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPRMIQVLSMISH---WLPYLNSSINPIIYNFMS 341
Cdd:cd15148  220 TVCFVPYHAFRIFYITSQLQNNSCYWKEILHKTNEimlLLSAFNSCLDPVMYFLLS 275
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
52-337 6.95e-15

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 74.09  E-value: 6.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15301    3 IVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEV-----IVADLTRFVKRQYIDLLIfcg 204
Cdd:cd15301   83 ASNASVLNLLIISFDRYFSVTRPLtyRARRTTKKAAVMIASAWIISLLLWPPWIyswpyIEGKRTVPAGTCYIQFLE--- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 pqwsdkTNQVVYQSVIIVLMYlLPLVLMTVTYSMIavvlWTgkipgaiESANRpmmdgnvnraeeQLESRKKAAKMLITV 284
Cdd:cd15301  160 ------TNPYVTFGTALAAFY-VPVTIMCILYWRI----WR-------ETKKR------------QKKQESKAAKTLSAI 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 285 VIGFAVCYFPvhlFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15301  210 LLAFIVTWTP---YNVLVLIKAFFPCSDTIPTELWDFSYYLCYINSTINPLCY 259
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
54-348 1.09e-14

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 73.43  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTE-TWYFGFAMCKIALFLQTTS 132
Cdd:cd15304    5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPL---RFKS-TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLlifcgpqwS 208
Cdd:cd15304   85 STASIMHLCAISLDRYIAIRNPIhhsRFNSrTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLL--------A 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKtNQVVYQSVIivlMYLLPLVLMTVTYSMiavvlwtgkipgaiesanrpmmdgNVNRAEEQLESRKKAAKMLITVVIGF 288
Cdd:cd15304  157 DE-NFVLIGSFV---AFFIPLTIMVITYFL------------------------TIKSLQQSISNEQKASKVLGIVFFLF 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 289 AVCYFPVHLFNILRYAdALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15304  209 VVMWCPFFITNVMAVI-CKESCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
54-340 1.52e-14

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 73.25  E-value: 1.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIcLPPTLLSDVTE-TWYFGFAMCKIALFLQTTS 132
Cdd:cd14987    5 FFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVAT-LPVWVVSLVQHnQWPMGEFTCKITHLIFSIN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRA--KIIILVIWIIAFLLALPEvivadlTRFVKRQYIDLL--IFCGPQWS 208
Cdd:cd14987   84 LFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIvrRIICVLVWLLAFVASLPD------TYFLKTVTSPSNneTYCRSFYP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQ---VVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipGAIESANRpmmdgnvnraeeqlESRKKAAKMLITVV 285
Cdd:cd14987  158 EESFKewlIGMELVSIVLGFVIPFPIIAVFYFLLA---------RAISASSD--------------QERKSSRKIIFSYV 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 286 IGFAVCYFPVH------LFNILRY------ADALRFVAPRMIQVLSMIshwlpylNSSINPIIYNFM 340
Cdd:cd14987  215 VVFLVCWLPYHtvvlldILSFLHLipfscqLENFLYAALHVTQCFSLV-------HCCVNPILYSFI 274
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
58-343 1.81e-14

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 72.94  E-value: 1.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSV 137
Cdd:cd15077    9 FLVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 138 FTLSAISVERWYAICYPL---RFKSTkrRAKIIILVIWIIAFLLALPEVivadltrFVKRQYI--DLLIFCGPQWSDKTN 212
Cdd:cd15077   89 WSLAVVAFERFLVICKPLgnfTFRGT--HAIIGCIATWVFGLAASLPPL-------FGWSRYIpeGLQCSCGPDWYTTNN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QVVYQSVIIVLM---YLLPLVLMTVTYSMIAVVLWTgkipgaiesanrpmmdgnVNRAEEQLESRKKA----AKMLITVV 285
Cdd:cd15077  160 KWNNESYVMFLFcfcFGVPLSIIVFSYGRLLLTLRA------------------VAKQQEQSASTQKAerevTKMVVVMV 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 286 IGFAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHwlpyLNSSINPIIYNFMSVQ 343
Cdd:cd15077  222 LGFLVCWLPYASFALWVVTNRGEPFDLRLASIPSVFSK----ASTVYNPVIYVFMNKQ 275
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
54-348 2.14e-14

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 72.63  E-value: 2.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTE-TWYFGFAMCKIALFLQTTS 132
Cdd:cd15305    5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPL---RFKS-TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLlifcgpqws 208
Cdd:cd15305   85 STASIMHLCAISLDRYVAIRNPIehsRFNSrTKAMMKIAAVWTISIGISMPIPVIGLQDDEKVFVNGTCVL--------- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIivlMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnRAEEQLESRKKAAKMLITVVIGF 288
Cdd:cd15305  156 NDENFVLIGSFV---AFFIPLIIMVITYCLTIQVL----------------------QRQQAINNERRASKVLGIVFFLF 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 289 AVCYFPVHLFNILrYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15305  211 LIMWCPFFITNIL-SVLCKEACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAF 269
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
61-236 2.24e-14

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 72.85  E-value: 2.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVFTL 140
Cdd:cd15073   12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 141 SAISVERWYAICYP-LRFKSTKRRAKIIILVIWIIAFLLAL----------PEVIVAdltrfvkrqyidlliFCGPQWS- 208
Cdd:cd15073   92 TVVAVDRYLTICRPdLGRKMTTNTYTVMILLAWTNAFFWAAmplvgwasyaLDPTGA---------------TCTINWRk 156
                        170       180
                 ....*....|....*....|....*...
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTY 236
Cdd:cd15073  157 NDSSFVSYTMSVIVVNFIVPLAVMFYCY 184
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
54-340 2.93e-14

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 72.46  E-value: 2.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADlAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15087    5 VIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIAD-DLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKSTKRR----AKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQwsd 209
Cdd:cd15087   84 FSSIYFLTVMSVDRYLVVLATVRSRRMPYRtyraAKIVSLCVWLLVTIIVLPFTVFAGVYSNELGRKSCVLSFPSPE--- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 ktnQVVYQSVII---VLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanRPMMDGNVNRAEEQleSRKKAAKMLITVVI 286
Cdd:cd15087  161 ---SLWFKASRIytlVLGFAIPVSTICILYTMMLYKL-------------RNMRLNSNAKALDK--AKKKVTLMVLVVLA 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 287 GFAVCYFPVHLFNILryadALRFVAPR--MIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15087  223 VCLFCWTPFHLSTVV----ALTTDLPQtpLVIGISYFITSLSYANSCLNPFLYAFL 274
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
55-341 3.17e-14

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 72.19  E-value: 3.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVA 134
Cdd:cd15156    6 VFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDL-LFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDllifCGPQWSDKTN 212
Cdd:cd15156   85 GSILFLTCISVDRFLAIVYPFRSKTlrTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSET----CFENFSSKTW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QVVYQSVII---VLMYLLPLVLMTVTYSMIavvlwtgkipgaIESANRPMmdgNVNRAEeqlESRKKAAKMLITVVIGFA 289
Cdd:cd15156  161 KTYLSKIVIfieIVGFFIPLILNVTCSTMV------------LKTLRRPN---TLSRSK---LNKKKVLKMIFVHLFIFC 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 290 VCYFPVH----LFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15156  223 FCFIPYNvnlvLYSLVRTQTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTS 278
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
50-348 3.20e-14

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 72.00  E-value: 3.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15331    1 VLTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYA---ICYPLRfkSTKRRAKIIILVIWIIAFLLALPevivadlTRFVKRQYIDLLIFCGPQ 206
Cdd:cd15331   81 VLCCTASILHLVAIALDRYWAvtnIDYIRR--RTAKRILIMIAVVWFVSLIISIA-------PLFGWKDEDDLDRVLKTG 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIavvlwtgkipgaIESANRpmmdgnvnraeeqlesRKKAAKMLITVVI 286
Cdd:cd15331  152 VCLISQDYGYTIFSTVGAFYVPLLLMIIIYWKI------------YQAAKR----------------ERKAARTLAIITG 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 287 GFAVCYFPVHLFNILRYADAlrfvAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15331  204 AFVVCWLPFFLVALVMPFCG----AWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
52-337 3.59e-14

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 71.92  E-value: 3.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd17790    3 IVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVI-----VADLTRFVKRQYIDLLifcg 204
Cdd:cd17790   83 ASNASVMNLLIISFDRYFSITRPLtyRAKRTPRRAAIMIGLAWLISFVLWAPAILfwqylVGERTVLAGQCYIQFL---- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 pqwsdktNQVVYQSVIIVLMYLLPLVLMTVTYsmiavvlWtgkipgaiesanrpmmdgnvnRAEEQLESRKKAAKMLITV 284
Cdd:cd17790  159 -------SQPIITFGTAIAAFYLPVTIMIILY-------W---------------------RIYRETIKEKKAARTLSAI 203
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 285 VIGFAVCYFPvhlFNILRYADAlrFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd17790  204 LLAFILTWTP---YNIMVLVST--FCKDCVPKTLWELGYWLCYVNSTVNPMCY 251
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
55-341 3.97e-14

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 72.03  E-value: 3.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTET-WYFGFAMCKIALFLQTTSV 133
Cdd:cd15967    6 VYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADL-LYLLTLPFLVVYYLKGRkWIFGQVFCKITRFCFNLNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVivadltrFVKRQYIDllifcGPQWSDKT 211
Cdd:cd15967   85 YGSIGFLTCISVYRYLAIVHPMRVmgRITTTHSVVISALVWLLVVIQSLPDL-------FFSKTNSN-----GTKCFDTT 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQ------VVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesANRPMMDGNVnraeeqlesRKKAAKMLITVV 285
Cdd:cd15967  153 FNdylesyLTYSLGWTVTGFVIPLLIILGCYGHVVVVL-----------CRNNNVDKGL---------KQRCLKLVIILI 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 286 IGFAVCYFPVHLF-NILRYADALR-----FVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15967  213 VLFSVCYIPYHVFrNLNLLSRILQkqgscTQWFRGIYIAHQVSRGLVCLNSALNPLVYLMGS 274
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
51-339 4.39e-14

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 71.76  E-value: 4.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAV-WRNRsmRTVTNIFIVNLAIADLAViIICLPP-TLLSDVTETWYFGFAMCKIALFL 128
Cdd:cd15118    2 ATICLHGIVSTLGIVENLLILWVVgFRLR--RTVISIWILNLALSDLLA-TLSLPFfTYYLASGHTWELGTTFCRIHSSI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 129 QTTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFV---KRQYIDLLIFC 203
Cdd:cd15118   79 FFLNMFVSGFLLAAISLDRCLLVVKPVWAQNhrNVAAAKKICGVIWAMALINTIPYFVFRDVIERKdgrKLCYYNFALFS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 -GPQWSD---KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnraeeQLESRKKAA- 278
Cdd:cd15118  159 pSPDNNHpicKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLII--------------------------RHRCRRRPGr 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 279 --KMLITVVIGFAVCYFPVHLFNILRY-ADALRFVAPRMIQVLSMISHwLPYLNSSINPIIYNF 339
Cdd:cd15118  213 fvRLVVSVVVSFALCWAPYHIFSIIEVmAHNQHSLRPLVIQGLPFATT-LAFLNSVLNPVLYVF 275
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
50-337 4.83e-14

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 71.52  E-value: 4.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLS---GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIAL 126
Cdd:cd15299    1 WQVVLIAFLTGILALVtiiGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEV-----IVADLTRFVKRQYIDL 199
Cdd:cd15299   81 SIDYVASNASVMNLLVISFDRYFSITRPLtyRAKRTTKRAGVMIGLAWVISFVLWAPAIlfwqyFVGKRTVPPDECFIQF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 200 LifcgpqwsdkTNQVVYQSVIIVLMYlLPLVLMTVTYsmiavvlWtgkipgaiesanrpmmdgnvnRAEEQLESRKKAAK 279
Cdd:cd15299  161 L----------SEPIITFGTAIAAFY-LPVTIMTILY-------W---------------------RIYKETIKEKKAAQ 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 280 MLITVVIGFAVCYFPvhlFNILRYADAlrFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15299  202 TLSAILLAFIITWTP---YNIMVLVNT--FCDSCIPKTYWNLGYWLCYINSTVNPVCY 254
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
58-337 5.13e-14

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 71.83  E-value: 5.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTET---WYFGFAMCKIALFLQTTSVA 134
Cdd:cd15006    8 VIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPHccwWIYTLLFCKVIKFLHKVFCS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRfvkrqyIDLLIFCGPQWSDKTNQV 214
Cdd:cd15006   88 VTVLSFAAIALDRYYSVLYPLERKISDAKSRDLVIYIWAHAVVASVPVFAVTNVTD------IYAMSTCTESWGYSLGHL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 215 VYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRPMMDGNVNRAEEQLESRKKAakMLITVVIGFAVCYFP 294
Cdd:cd15006  162 VYVIIYNITTVILPVAVVFLFMILIRRALSASQKKKVIIAALRTPQNTISIPYVSQREAELHA--MLLSMVLVFILCSVP 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 405966368 295 VHLFNILRYAdalrFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15006  240 YATLVIYRTI----LNISDISVFLLLTAIWLPKVSLLANPLLF 278
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
48-348 6.82e-14

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 70.98  E-value: 6.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  48 WEWGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALF 127
Cdd:cd15333    3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 128 LQTTSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVivadLTRFVKRQyiDLLIFCgp 205
Cdd:cd15333   83 SDITCCTASILHLCVIALDRYWAITDAVEYskKRTPKRAAVMIALVWVISISISLPPF----FWRQAKAE--EEVSEC-- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 qwSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnRAEEqlesrKKAAKMLITVV 285
Cdd:cd15333  155 --VVNTDHILYTVYSTVGAFYIPTLLLIALYGRIYVEA----------------------RARE-----RKATKTLGIIL 205
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 286 IGFAVCYFPVHLFN-ILRYADALRFVAPRMIQVLSmishWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15333  206 GAFIVCWLPFFIISlVLPICKDACWFHLAIFDFFT----WLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
50-239 1.09e-13

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 70.56  E-value: 1.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLavIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15175    1 WFLPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADI--LFLLTLPFWAASAAKKWVFGEEMCKAVYCLY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPL---RFKS-TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIdlLIFCGP 205
Cdd:cd15175   79 KMSFFSGMLLLMCISIDRYFAIVQAAsahRHRSrAVFISKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTC--SIFTNN 156
                        170       180       190
                 ....*....|....*....|....*....|....
gi 405966368 206 QWSDKTNQVVYQsviIVLMYLLPLVLMTVTYSMI 239
Cdd:cd15175  157 KQTLSVKIQISQ---MVLGFLVPLVVMSFCYSVI 187
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
52-337 1.32e-13

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 70.24  E-value: 1.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15295    3 LLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFK---STKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQyidllifCGPQWS 208
Cdd:cd15295   83 LCTASVYNIVLISYDRYQSVSNAVSYRnqqTATLRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGE-------CEPEFF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNqvvYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiesanrpmmdgnvnraeEQLESRkKAAKMLITVVIGF 288
Cdd:cd15295  156 SNWY---ILAITSVLEFLVPVILVAYFNTQIYWSLW------------------------KRLRDR-KLAKSLAIILGTF 207
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 405966368 289 AVCYFPVHLFNILRYAdalrfVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15295  208 AICWAPYSLFTIIRAA-----CEKHRGSPWYNFAFWLQWFNSFINPFLY 251
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
53-341 1.43e-13

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 70.15  E-value: 1.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd14964    2 TIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKiiilVIWIIAFLLALPEVIVadLTRFVKRQYIDLLIFCGPQWSDKTN 212
Cdd:cd14964   82 NLASIWTTLVLTYHRYFALCGPLKYTRLSSPGK----TRVIILGCWGVSLLLS--IPPLVGKGAIPRYNTLTGSCYLICT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QVVYQSVIIVLMYLLPLVLMtvTYSMIAVVLWTGKIPGAIESANRPMMDGNvnraeeqlesrKKAAKMLITVVIGFAVCY 292
Cdd:cd14964  156 TIYLTWGFLLVSFLLPLVAF--LVIFSRIVLRLRRRVRAIRSAASLNTDKN-----------LKATKSLLILVITFLLCW 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 405966368 293 FPVHLFNILRYADALRFVAPRMiqvlSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd14964  223 LPFSIVFILHALVAAGQGLNLL----SILANLLAVLASTLNPFIYCLGN 267
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
54-339 1.61e-13

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 70.22  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTET-WYFGFAMCKIALFLQTTS 132
Cdd:cd15921    5 TAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDL-LLVCTLPLRLTYYVLNShWPFGDIACRIILYVLYVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPevivadLTRFVKRQYIDLLIFCGPQWSDK 210
Cdd:cd15921   84 MYSSIYFLTALSVFRYLALVWPYLYlrVQTHSVAGIICGLIWILMGLASSP------LLFAKSKQHDEGSTRCLELAHDA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQV-VYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPgaiESANRPmmdgnvnraeeqleSRKKAAKMLITVVIGFA 289
Cdd:cd15921  158 VDKLlLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPA---LGRTRP--------------SRRKACALIIISLGIFL 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 290 VCYFPVHLFNILrYADALRFVAPRMIQVLSM-----ISHWLPYLNSSINPIIYNF 339
Cdd:cd15921  221 VCFLPYHIVRTI-HLITERQIKESCGYILRVrkaavITLCLAASNSCFDPLLYFF 274
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
52-348 1.62e-13

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 70.17  E-value: 1.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTEtWYFGFAMCKIALFLQTT 131
Cdd:cd15172    3 VPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADI-LFVLTLPFWAVYEAHQ-WIFGNFSCKLLRGIYAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLR-FK---STKRRAKIIILVIWIIAFLLALPEVIVADLTRF-VKRQYIdllifCGPQ 206
Cdd:cd15172   81 NFYSGMLLLACISVDRYIAIVQATKsFRlrsRTLAYSKLICAAVWLLAILISLPTFIFSEVYDFgLEEQYV-----CEPK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 ----WSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnrAEEQLESRKKAAKMLI 282
Cdd:cd15172  156 ypknSTAIMWKLLVLSLQVSLGFFIPLLVMIFCYSFIIKTL-----------------------LQAQNSQRHKAVRVVV 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 283 TVVIGFAVCYFPVHL--------FNILRYADALRFVAPRMiqvlsMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15172  213 AVVLVFLVCQVPYNIvllieainLGEQQSCSSEKAVAYAK-----TITECLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
54-339 2.11e-13

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 70.07  E-value: 2.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTE-TWYFGFAMCKIALFLQTTS 132
Cdd:cd15159    5 LFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDI-LFTLALPGRIAYYALGfDWPFGDWLCRLTALLFYIN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKR--RAKIIILVIWIIAFLLALPEVIV---------------ADLTRFVKRQ 195
Cdd:cd15159   84 TYAGVNFMTCLSVDRYIAVVHPLRRHRLRKvkVVRYICVFVWVLVFLQTLPLLFMpmtkemggritcmeyPNFEKIKRLP 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 196 YIdLLIFCgpqwsdktnqvvyqsviiVLMYLLPLVLMTVTYSMIAVVLwtgkipgaIESANRpmmdgnvNRAEEQLESRK 275
Cdd:cd15159  164 LI-LLGAC------------------VIGFGVPVGIILFCYSQITLKL--------CRTAKE-------NPLTEKSGHHK 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 276 KAAKMLITVVIGFAVCYFPVHLfNILRYADALRFVAP-----RMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15159  210 KACNVILLVLLVFVVCFSPYHL-NIIQFMIRKLLYQPscselKAFKISLQITVCLMNLNCCLDPFIYFF 277
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
55-346 2.49e-13

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 69.31  E-value: 2.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLavIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVA 134
Cdd:cd15182    6 FYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDL--LFTFTLPFWASYHSSGWIFGEILCKAVTSIFYIGFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLrfkSTKRRAKIIILVIWIIA-----FLLALPEVIvadLTRFVKRQYIDLLifCGPQWSD 209
Cdd:cd15182   84 SSILFLTLMTIDRYLAVVHPL---SALRSRKLRYASLVSVAvwvisILASLPELI---LSTVMKSDEDGSL--CEYSSIK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSviiVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgnvnraeeqLESRKKAAKMLITVVIGFA 289
Cdd:cd15182  156 WKLGYYYQQ---NLFFLIPLGIIVYCYVRILQTLMRTR-----------------------TMRKHRTVKLIFVIVLVFF 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 290 VCYFPVHLFNILRYADALRFVAPRMIQVLS---MISHWLPYLNSSINPIIYNFMSVQTKG 346
Cdd:cd15182  210 LSWAPYNIVIFLRSLKDLTIPICECSKQLDyafYICRNIAFSHCCLNPVFYVFVGVKFRN 269
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
50-341 2.61e-13

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 69.39  E-value: 2.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFaVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15372    1 RLVPSLYTLVFLVGLPANGLALW-VLATQVKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKSTkrRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCG---PQ 206
Cdd:cd15372   80 YGNMYCSVLLLMCISLDRYLAVVHPFFARTL--RSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNITLCHdvlPL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnraeeqLESRKK---AAKMLIT 283
Cdd:cd15372  158 DEQDTYLFYYFACLAVLGFLLPLVVILFCYGSVLHTL---------------------------LRSGQRyghAMKLTVL 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 284 VVIGFAVCYFPVHLFNILRYADAlRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15372  211 VLVSFVLCFTPSNLLLLLHYSDP-TLDDGGNLYIVYMVSLAISTLNSCVDPFIYYYVS 267
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
54-304 2.72e-13

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 69.41  E-value: 2.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAviIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15923    5 AIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLL--LLISLPFKMHSYRRESAGLQKLCNFVLSLYYINM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFllalpeVIVADLTRFVKRQYIDLLiFCGpQWSDKTNQ 213
Cdd:cd15923   83 YVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVL------VVTISIPYFLLDSSNEKT-MCF-QRTKQTES 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 VVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesANRPmmdGNVNRAEEQlesrKKAAKMLITVVIGFAVCYF 293
Cdd:cd15923  155 LKVFLLLEIFGFLLPLIIMTFCSARVIHTL-----------QKRL---DDVGSRSET----KQCIRVIMANLIVFIVCFL 216
                        250
                 ....*....|.
gi 405966368 294 PVHLFNILRYA 304
Cdd:cd15923  217 PVHVGFFVKFI 227
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
50-343 3.82e-13

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 69.06  E-value: 3.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIV---GLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIAL 126
Cdd:cd15082   11 WNFTVLAALMFVVtslSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPL-RFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKrqyidLLIFCGP 205
Cdd:cd15082   91 FAVTFFGIVALWSLAVLAFERFFVICRPLgNIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSK-----IGTTCEP 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 QW-SDKTNQVVYQSVIIVLMYLLPLVLMTVTY-SMIAVVLWTGKIPGAIESANRPmmdgnvnraeeqlesRKKAAKMLIT 283
Cdd:cd15082  166 NWySGNMHDHTYIITFFTTCFILPLGVIFVSYgKLLQKLRKVSNTQGRLGNARKP---------------ERQVTRMVVV 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 284 VVIGFAVCYFPVHLFNILRYADALRFVAPRmiqvLSMISHWLPYLNSSINPIIYNFMSVQ 343
Cdd:cd15082  231 MIVAFMVCWTPYAAFSILVTAHPTIHLDPR----LAAIPAFFSKTAAVYNPIIYVFMNKQ 286
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
42-343 5.82e-13

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 68.74  E-value: 5.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  42 YVFPDDWEWGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAM 121
Cdd:cd15084    3 HLAPRSTYLTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 122 CKIALFLQTTSVAVSVFTLSAISVERWYAICYPL-RFKSTKRRAKIIILVIWIIAFLLALPEVIvaDLTRFVKRqyiDLL 200
Cdd:cd15084   83 CEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMgDFRFQQRHAVSGCAFTWGWSLLWTSPPLF--GWSSYVPE---GLR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 201 IFCGPQW-SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipGAIESANRpmmdgnvnRAEEQLESRKKAAK 279
Cdd:cd15084  158 TSCGPNWyTGGTNNNSYILALFVTCFALPLSTIIFSYSNLLLTL------RAVAAQQK--------ESETTQRAEKEVTR 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 280 MLITVVIGFAVCYFPVHLFNILRYADALRFVAPrmiqVLSMISHWLPYLNSSINPIIYNFMSVQ 343
Cdd:cd15084  224 MVIAMVMAFLICWLPYATFAMVVATNKDVVIQP----TLASLPSYFSKTATVYNPIIYVFMNKQ 283
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
67-349 6.98e-13

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 68.05  E-value: 6.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  67 NVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVFTLSAISVE 146
Cdd:cd15334   18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 147 RWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIdllifcgpqwsDKTNQVVYQSVIIVLM 224
Cdd:cd15334   98 RYRAITDAVEYarKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSREDECI-----------IKHDHIVFTIYSTFGA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 225 YLLPLVLMTVTYSMIavvlwtgkipgaIESANRpmmdgnvnraeeqlesRKKAAKMLITVVIGFAVCYFPVHLFNILRYA 304
Cdd:cd15334  167 FYIPLALILILYYKI------------YRAATR----------------ERKAATTLGLILGAFVICWLPFFVKEVIVNT 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 405966368 305 DALRFVAPRMIQVLSmishWLPYLNSSINPIIYNFMSVQTKGAFH 349
Cdd:cd15334  219 CDSCYISEEMSNFLT----WLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
53-342 7.42e-13

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 68.30  E-value: 7.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIII-CLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15198    4 LIFLGVILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGtALSQIIWELLGDRWMAGDVACRLLKLLQAS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLrfkSTKRRAKIIILVIWIIAFLLALP------EVIVADLTRFVKRQYIDLLIFCG- 204
Cdd:cd15198   84 ARGASANLVVLLALDRHQAIRAPL---GQPLRAWKLAALGWLLALLLALPqayvfrVDFPDDPASAWPGHTLCRGIFAPl 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 PQWsdktNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLW--TGKIPGAIESANRPMMDGNVNRAEEQLESRK-KAAKML 281
Cdd:cd15198  161 PRW----HLQVYATYEAVVGFVAPVVILGVCYGRLLLKWWerANQAPGAKKPWKKPSKSHLRATAPSALPRAKvKTLKMT 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 282 ITVVIGFAVCYFPVHLFNILRYADALRFVAPRMIQVLSMIShwlpYLNSSINPIIYNFMSV 342
Cdd:cd15198  237 LVIALLFVGCSLPYFIAELAAAFGSGDWEPEKVAAALGVMA----VANSATNPFVFLFFNA 293
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
50-348 9.01e-13

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 68.35  E-value: 9.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15126    1 YGILLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYME 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWII---AFLLALPEVIVADLTRFVKRQYIDLLIFCGPQ 206
Cdd:cd15126   81 VTSLGVTTFSLCALGIDRFHAATSPQPKARPVERCQSILAKLAVIwvgSMTLAVPELLLWQLAQETSPGSGMVIDTCIMK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQVVYQSVIIV----------LMYLLPlVLMTVTYSMIavvlwTGKIPGAIESANRPMMdgnvnRAEEQLESRKK 276
Cdd:cd15126  161 PSPNLPESLYSLVLTYqnarmwwyfgCYFCLP-ILFTVTCQLV-----TLRVSGTSGSSKECKD-----IKHGQCERQLN 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 277 AAKMLITVVigFAVCYFPVHLFNILrYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15126  230 CTVAGLAVV--YGVCTLPENVCNIV-VAYTSLEVSDQTLDLLSLINQFFLFFKCAVTPVLLLCLCKPLGQAF 298
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
54-345 9.95e-13

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 67.90  E-value: 9.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIClpPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15187    5 VLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSL--PFQAYYLLDQWVFGNAMCKIVSGAYYIGF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAI---CYPLRFKsTKRRAKIIILVIWIIAFLLALPEVIvadltrFVKRQYIDLLIFCGPQWSDK 210
Cdd:cd15187   83 YSSMFFITLMSIDRYLAIvhaVYALKVR-TASHGTILSLALWLVAILASVPLLV------FYQVASEDGRLQCIPFYPGQ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TN--QVVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanrpmmdGNVNRAEEQleSRKKAAKMLITVVIGF 288
Cdd:cd15187  156 GNswKVFTNFEVNILGLLIPFSILIFCYHNIL---------------------RNLRRCHNQ--NKTKAIKLVFIVVIVF 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 289 AVCYFPvhlFNILRYADALRFV-------APRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTK 345
Cdd:cd15187  213 FLFWTP---FNVVLFLDSLHSLhiidgcqNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFK 273
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
54-348 1.05e-12

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 67.55  E-value: 1.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTET-WYFGFAMCKIALFLQTTS 132
Cdd:cd15306    5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAmWPLPLVLCPIWLFLDVLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWI--IAFLLALPEVIVADLTRFVKRQYIDLLIFCGPqwsdk 210
Cdd:cd15306   85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVwlISIGIAIPVPIKGIETDVDNPNNITCVLTKER----- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 tnqvvYQSVII---VLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmdgnvnrAEEQLESRKKAAKMLITVVIG 287
Cdd:cd15306  160 -----FGDFILfgsLAAFFTPLAIMIVTYFLTIHAL-----------------------RKQTITNEQRASKVLGIVFFL 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 288 FAVCYFPVHLFNIlryadALRFVAP---RMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15306  212 FLLMWCPFFITNI-----TSVLCDScnqTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAF 270
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
52-348 1.84e-12

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 66.69  E-value: 1.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLP-PTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15302    3 LALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPfYTVYVLNGDYWPLGWVLCDLWLSVDY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWsdk 210
Cdd:cd15302   83 TVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQYFTGQGRSLPEGECYVQF--- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnVNRAEEQLESrkkaakmlITVVIG-FA 289
Cdd:cd15302  160 MTDPYFNMGMYIGYYWTTLIVMLILYAGIYRA---------------------ANRARKALRT--------ITFILGaFV 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 290 VCYFPVHlfnILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15302  211 ICWTPYH---ILATIYGFCEAPPCVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
54-339 2.72e-12

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 66.81  E-value: 2.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15316    5 IVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSDKT 211
Cdd:cd15316   85 YASLFHLCFISVDRYIAVTDPLVYptKFTVSVSGICISVSWIFSLTYSFSVFYTGVNDDGLEELVNALNCVGGCQIILNQ 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSviivLMYLLPLVLMTVTYSMIAVVLWTGKIpgAIESANRPMMDGNVNRAEEQLESRKKAAKMLITVVIGFAVC 291
Cdd:cd15316  165 NWVLVDF----LLFFIPTFAMIILYGKIFLVAKQQAR--KIEMTSSKAESSSESYKDRVARRERKAAKTLGITVIAFLVS 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 405966368 292 YFPvhlFNILRYADA-LRFVAPRMIQvlsMISHWLPYLNSSINPIIYNF 339
Cdd:cd15316  239 WLP---YLIDVLIDAfMNFITPPYIY---EICCWCAYYNSAMNPLIYAL 281
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
61-339 2.97e-12

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 66.36  E-value: 2.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPpTLLSDVTE--TWYFGFAMCKIALFLQTTSVAVSVF 138
Cdd:cd15380   12 FFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDL-VFVLGLP-FWAENIRNqfNWPFGNFLCRVISGVIKANLFISIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 139 TLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYID-LLIFCGPQWsdktnQVV 215
Cdd:cd15380   90 LVVAISQDRYRTLVHTMtsRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPDLNISAcILLFPHEAW-----HFA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 216 YQSVIIVLMYLLPLVlmtvtysmiAVVLWTGKIPGAIESANRpmmdgnVNRAEEQLESRKKAAKMLITVVIGFAVCYFPV 295
Cdd:cd15380  165 RRVELNIVGFLLPLA---------AIVFFNFHIIASLRERTE------ESRKRCGGLKDTKATRLILTLVLMFLVCWTPY 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 405966368 296 HLFNILRYADALRFVA----PRMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15380  230 HFFAFLDFLFQVEVIQgcfwEEFIDLGLQLANFFAFANSCLNPVIYVF 277
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
55-340 3.03e-12

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 66.39  E-value: 3.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVA 134
Cdd:cd15185    6 LYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDL-LFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAIC---YPLRFKsTKRRAKIIILVIWIIAFLLALPEVIvadltrFVKRQYIDLLIFCGPQWSDKT 211
Cdd:cd15185   85 SEIFFIILLTIDRYLAIVhavFALRAR-TVTFGIITSIITWGLAVLAALPEFI------FYETQELFEEFLCSPLYPEDT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 --NQVVYQSVIIVLMYL-LPLVLMTVTYSMIAVVLWtgKIPGaiesanrpmmdgnvnraeeqlESRKKAAKMLITVVIGF 288
Cdd:cd15185  158 edSWKRFHALRMNIFGLaLPLLIMVICYTGIIKTLL--RCPS---------------------KKKYKAIRLIFVIMVVF 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 289 AVCYFPVHLFNILRYADALRFVA----PRMIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15185  215 FIFWTPYNLVLLLSAFQSIFFETdcerSKHLDLAMQVTEVIAYTHCCINPVIYAFV 270
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
55-340 3.82e-12

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 66.05  E-value: 3.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVA 134
Cdd:cd15183    6 LYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDL-VFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLrfksTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSDKT--N 212
Cdd:cd15183   85 SEIFFIILLTIDRYLAIVHAV----FALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSliR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QVVYQSVIIVLMYL-LPLVLMTVTYSMIAVVLwtgkipgaiesANRPMmdgnvnraeeqlESRKKAAKMLITVVIGFAVC 291
Cdd:cd15183  161 WKRFQALKLNLLGLiLPLLVMIICYTGIINIL-----------LRRPN------------EKKAKAVRLIFVITLLFFLL 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 405966368 292 YFPVHLFNILRYADALRFV----APRMIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15183  218 WTPYNLAAFVSAFQDVLFTpsceQSQQLDLALQVTEVIAYTHCCVNPVIYVFV 270
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
52-348 4.93e-12

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 65.33  E-value: 4.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15335    3 IVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVadltrfvkRQYIDLLIfcGPQWSD 209
Cdd:cd15335   83 CCTCSILHLCVIALDRYWAITDAIEYarKRTAKRAGLMILTVWTISIFISIPPLFW--------RNHHDANI--PSQCII 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIVLMYLLPLVLMTVTYSMIavvlwtgkipgaIESANRpmmdgnvnraeeqlesRKKAAKMLITVVIGFA 289
Cdd:cd15335  153 QHDHVIYTIYSTFGAFYIPLTLILILYYRI------------YHAASR----------------ERKAARILGLILGAFI 204
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 290 VCYFPVHLFNILrYADALRFVAPRMIQVLSmishWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15335  205 LSWLPFFIKELI-VGLSVMTVSPEVADFLT----WLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
55-154 5.25e-12

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 66.33  E-value: 5.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFI--VGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTE-TWYFGFAMCKIALFLQTT 131
Cdd:cd15005    4 LTTLGLIlcVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGsGWIYGALSCKVIAFLAVL 83
                         90       100
                 ....*....|....*....|...
gi 405966368 132 SVAVSVFTLSAISVERWYAICYP 154
Cdd:cd15005   84 FCFHSAFTLFCIAVTRYMAIAHH 106
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
54-341 6.20e-12

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 65.56  E-value: 6.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTET-WYFGFAMCKIALFLQTTS 132
Cdd:cd15368    5 VVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDL-MLACFLPFQIVYHIQRNhWIFGKPLCNVVTVLFYAN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLL-ALPEVIVADLTRFVKRQYIdLLIFCGPQWSDKT 211
Cdd:cd15368   84 MYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLtALSPLERTDLTYYVKELNI-TTCFDVLKWTMLP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVIIVLMYLLPLVLMTVTysmiaVVLWTGKIPGAIESANRpmmDGNvnraeeqlESRKKAAKMLITVVIGFAVC 291
Cdd:cd15368  163 NIAAWAAFLFTLFILLFLIPFIIT-----VYCYVLIILKLVQTSER---YGR--------EQKRRAIYLALIVLLVFITC 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 292 YFP------VHLFNILRYADALrFVAPRMIQVLSMishwlpyLNSSINPIIYNFMS 341
Cdd:cd15368  227 FAPnnfillAHMVSRLFYGKSL-YHAYKLTLSLSC-------LNSCLDPFIYYFAS 274
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
53-347 6.26e-12

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 65.16  E-value: 6.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVtnIFIVNLAIADLAVIIICLPPTLLSD--VTETWYFGFAMCKIALFLQT 130
Cdd:cd15220    3 LFCMVLLDLTALVGNTAVMVVIAKTPHLRKF--AFVCHLCVVDLLAALLLMPLGILSSspFFLGVVFGEAECRVYIFLSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVADLTrfvKRQYIDLLIFCGPQWS 208
Cdd:cd15220   81 CLVSASILTISAISVERYYYIVHPMRYevKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSY---GGPAPIAARHCSLHWS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGkipgaiesanrpmmdgnvnraeeqlesrkKAAKMLITVVIGF 288
Cdd:cd15220  158 HSGHRGVFVVLFALVCFLLPLLLILVVYCGVFKVFGGG-----------------------------KAALTLAAIVGQF 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPRMIQVLSmishWLPYLNSSINPIIYNFMSVQTKGA 347
Cdd:cd15220  209 LCCWLPYFAFHLYSALAASPVSGGEAEEVVT----WLAYSCFAVNPFFYGLLNRQIREE 263
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
54-337 6.34e-12

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 65.49  E-value: 6.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVlvcFAVW----RNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15376    5 PILGVEFLVAVLGNG---LALWlfvtRERRPWHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRfVKRQYIDLLIFcgpqw 207
Cdd:cd15376   82 TCNLYGSIFFITCISLNRYLGIVHPFftRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLEV-ERHNKTECLGT----- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYL---LPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgNVNRAEeqlesRKKAAKMLITV 284
Cdd:cd15376  156 AVDSRLPTYLPYSLFLAVVgcgLPFLLTLASYLAIVWAVLRSP---------------GITTLE-----KRKVAALVAVV 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 285 VIGFAVCYFPVHLF---NILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15376  216 VALYAVSFVPYHILrnlNLYRRLQWLKAAASLRIYFAYQVTKGLVTLNMCIHPLLY 271
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
54-341 9.01e-12

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 64.81  E-value: 9.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQTTS 132
Cdd:cd15199    5 SLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADV-LLLICLPFKAYFYLNgNRWSLGGGTCKALLFMLSLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPlRFKS---TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVK-RQYidllifcGPQwS 208
Cdd:cd15199   84 RGVSIAFLTAVALDRYFRVVHP-RGKKnslSLQAAPYISFLVWLLLVGLTIPTLLASQPKNFTEcNSF-------SPK-D 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLmtVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeeqlesRKKAAKMLITVVIGF 288
Cdd:cd15199  155 DEDFSDTWQEAVFFLQFLLPFGL--IVFCTVRIIRRLKKRLRDVGKQPK----------------LQRAMALVTSVVVVF 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 289 AVCYFP-------VHLFNILRYADALRFVAPrmiqvLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15199  217 GFCFLPcflarvlMLIFQNKESCNALNIAVH-----TYDVTMCLTYLNSVLDPIVYCFSS 271
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
58-337 1.54e-11

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 64.40  E-value: 1.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTE-TWYFGFAMCKIALFLQTTSVAVS 136
Cdd:cd15381    9 IIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADL-LLVCCLPFWAINISNGfNWPFGEFLCKSVNAVIYMNLYSS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 137 VFTLSAISVERWYAICYPLRFKSTKRR--AKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLI-FCGPQWSDKTNq 213
Cdd:cd15381   88 IYFLMMVSIDRYLALVKTMSSGRMRRPacAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNITACVLdYPSEGWHVALN- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 vvyqSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanrpmmDGNVNRAEEQLESRKKAAKMLITVVIGFAVCYF 293
Cdd:cd15381  167 ----ILLNVVGFLIPLSIITFCSTQIIQVL-----------------RNNKMQKFKEIQTERKATVLVLAVLLMFFICWL 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 405966368 294 PVHLFNILRYADALRFVA----PRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15381  226 PFHIFTFLDTLHKLGLISgcrwEDILDIGTQIATFLAYSNSCLNPLLY 273
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
60-339 1.55e-11

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 64.41  E-value: 1.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  60 FIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLavIIICLPPTLLSDVTE--TWYFGFAMCKIALFLQTTSVAVSV 137
Cdd:cd15189   11 CLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADL--VFVSGLPFWAMNILNqfNWPFGELLCRVVNGVIKVNLYTSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 138 FTLSAISVERWYAICYPLRFKSTKRR--AKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDllifCGPQWSDKTNQVV 215
Cdd:cd15189   89 YLLVMISQDRYLALVKTMAARRLRRRryAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLNITA----CVLLYPHEAWHFA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 216 YQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgNVNRAEEQLESrkKAAKMLITVVIGFAVCYFPV 295
Cdd:cd15189  165 HIVLLNIVGFLLPLLVITFCNYNILQALRTRE---------------ESTRCEDRNDS--KATALVLAVTLLFLVCWGPY 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 405966368 296 HLFNILRYADALRFVAP----RMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15189  228 HFFTFLDFLFDVGVLDEcfweHFIDIGLQLAVFLAFSNSCLNPVLYVF 275
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
52-157 1.61e-11

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 64.20  E-value: 1.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15232    3 LFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTW 82
                         90       100
                 ....*....|....*....|....*.
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRF 157
Cdd:cd15232   83 SLGSELLLLTAMAYDRYVAICHPLHY 108
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
57-337 1.67e-11

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 64.06  E-value: 1.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  57 ALTFIVGLS--GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVA 134
Cdd:cd15054    6 FLCLIILLTvaGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSDKTN 212
Cdd:cd15054   86 ASILNLCVISLDRYLLIISPLRYKLrmTPPRALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSGTVEGQCRLLV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QVVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanrpmmdgnvnraeeqLESRK--KAAKMLITVVIGFAV 290
Cdd:cd15054  166 SLPYALVASCLTFFLPSGAICFTYCRIL------------------------------LAARKalKASLTLGILLGMFFV 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 405966368 291 CYFPVHLFNILRyaDALRFVAPRMIQVLSmishWLPYLNSSINPIIY 337
Cdd:cd15054  216 TWLPFFVANVVQ--AVCDCVSPGLFDVLT----WLGYCNSTMNPIIY 256
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
56-345 2.20e-11

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 64.04  E-value: 2.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  56 YALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIiCLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAV 135
Cdd:cd15153    7 YIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVL-SLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 136 SVFTLSAISVERWYAICYPLRFKSTKRRAKIIilviwiiafllalpevIVADLTRFVKRQYIDLLIFCGPQWSDKTNQVV 215
Cdd:cd15153   86 SICFLTCISIQRCFFLLHPFKARDWKRRYDVG----------------ISAAVWIVVGLACLPFPLLRSKSLSNNNRSCF 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 216 YQSVIIVLMYLLPLVLMTVT------YSMIAVVLWTGKIPGAIESAnrpmmdgnvNRAEEQLESRKKAAKMLITVVIGFA 289
Cdd:cd15153  150 ADLGMKKLNFGAAIAMMTVAelfgfvIPLFIIAWCTWKTENSLRQR---------NKQQQSTSEKQKALRMVRMCAAVFF 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 290 VCYFPVHL---------FNILRYADALRFvaprmIQVLSMISHWLPYLNSSINPIIYNFMSVQTK 345
Cdd:cd15153  221 ICFAPYHInflfylmvsESIITNCEVSQV-----ILQFHPISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
54-162 2.60e-11

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 63.66  E-value: 2.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPP----TLLSDVtetWYFGFAMCKIALFLQ 129
Cdd:cd15366    5 TLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDL-LYIATLPLwidyFLHRDN---WIHGPESCKLFGFIF 80
                         90       100       110
                 ....*....|....*....|....*....|...
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKSTKR 162
Cdd:cd15366   81 YTNIYISIAFLCCISVDRYLAVAHPLRFAKVRR 113
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
54-343 4.59e-11

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 62.87  E-value: 4.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15075    5 IIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVAFFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPL-RFKSTKRRAKIIILVIWIIAFLLALPEvivadLTRFVKRQYIDLLIFCGPQW-SDKT 211
Cdd:cd15075   85 IAALCTVAVIAVDRLFVVCKPLgTLTFQTRHALAGIASSWLWSLIWNTPP-----LFGWGSYQLEGVMTSCAPDWySRDP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESanrpmmdGNVNRAEEQLesrkkaAKMLITVVIGFAVC 291
Cdd:cd15075  160 VNVSYILCYFSFCFAIPFAIILVSYGYLLWTLRQVAKLGVAEG-------GSTAKAEVQV------ARMVVVMVMAFLLC 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 405966368 292 YFPVHLFNILRYADALRFVAPrMIQVLSMishWLPYLNSSINPIIYNFMSVQ 343
Cdd:cd15075  227 WLPYAAFALTVVSKPDVYINP-LIATVPM---YLAKSSTVYNPIIYIFMNKQ 274
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
66-339 5.89e-11

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 62.49  E-value: 5.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  66 GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSvaVSVFTLSAISV 145
Cdd:cd15070   17 GNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVTIHFYSCLFMSCLLVVFTH--ASIMSLLAIAV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 146 ERWYAICYPLRFK--STKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIfCGPQWSDKTNQVVYQSVIIVL 223
Cdd:cd15070   95 DRYLRVKLTVRYRivTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQ-CQFTSVMRMDYMVYFSFFTWI 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 224 myLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgnVNRAEEQLESRK------KAAKMLITVVIGFAVCYFPVHL 297
Cdd:cd15070  174 --LIPLVIMCALYVDIFYIIRNKL----------------SQNATGFRETGAfygrefKTAKSLALVLFLFAVCWLPLSI 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 405966368 298 FNILRYadalrfVAPRMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15070  236 INCVVY------FNPKVPKIALYLGILLSHANSMMNPIVYAC 271
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
52-348 5.98e-11

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 62.49  E-value: 5.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVcFAVWRNRSMRTVTNIFIVNLAIADLAVIIIcLPPTLLSDVTET-WYFGFAMCKiaLFLQT 130
Cdd:cd15120    3 IAVALFVTFLVGLVVNGLY-LWVLGFKMRRTVNTLWFLHLILSNLIFTLI-LPFMAVHVLMDNhWAFGTVLCK--VLNST 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAV--SVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFC-GP 205
Cdd:cd15120   79 LSVGMftSVFLLTAISLDRYLLTLHPVwsRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTICQNNYAlST 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 QWSDKTNQVVYQSVIIVLM-------YLLPLVLMTVTYSMIAVvlwtgkipgaiesanrPMMDGNVNRAeeqlesrKKAA 278
Cdd:cd15120  159 NWESAEVQASRQWIHVAMFvfrfllgFLLPFLIITFCYVRMAL----------------KMKERGLARS-------SKPF 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 279 KMLITVVIGFAVCYFPVHLFNILRYAdalRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15120  216 KVMFTAVVSFFVCWLPYHLHSGLVLT---RGRPPSLTDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
52-158 6.02e-11

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 63.49  E-value: 6.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWrNRSMRTVTNIFIVNLAIADLavIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:PHA02638 101 IKIFYIIIFILGLFGNAAIIMILF-CKKIKTITDIYIFNLAISDL--IFVIDFPFIIYNEFDQWIFGDFMCKVISASYYI 177
                         90       100
                 ....*....|....*....|....*..
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFK 158
Cdd:PHA02638 178 GFFSNMFLITLMSIDRYFAILYPISFQ 204
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
54-236 7.68e-11

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 62.09  E-value: 7.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRT-VTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15219    4 VLLVVVLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIfCGPQWSDKTN 212
Cdd:cd15219   84 TSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLSWLGYSSLYASCTL-HLPREEERRR 162
                        170       180
                 ....*....|....*....|....
gi 405966368 213 QVVYQSVIIVLMYLLPLVLMTVTY 236
Cdd:cd15219  163 FAVFTAFFHAFTFLLSLLVLCVTY 186
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
50-343 8.31e-11

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 62.23  E-value: 8.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIvglsgNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15081   18 WMIFVVFASVFT-----NGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPlrFKSTKRRAKIIILVIWI----IAFLLALPeviVADLTRFVKRqyiDLLIFCGP 205
Cdd:cd15081   93 SVCGITGLWSLTIISWERWVVVCKP--FGNIKFDGKLAIVGIIFswvwSAVWCAPP---IFGWSRYWPH---GLKTSCGP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 QWSDKTNQVVYQSVIIVLMY---LLPLVLMTVTYsmIAVVLwtgkipgAIESANRPMMDgnvnrAEEQLESRKKAAKMLI 282
Cdd:cd15081  165 DVFSGSSDPGVQSYMIVLMItccIIPLAIIILCY--LQVWL-------AIRAVAQQQKE-----SESTQKAEKEVSRMVV 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 283 TVVIGFAVCYFPVHLFNILRYADALRFVAPRMiqvlSMISHWLPYLNSSINPIIYNFMSVQ 343
Cdd:cd15081  231 VMIFAYCFCWGPYTFFACFAAANPGYAFHPLA----AALPAYFAKSATIYNPIIYVFMNRQ 287
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
55-243 8.52e-11

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 62.08  E-value: 8.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTEtWYFGFAMCKIALFLQTTSVA 134
Cdd:cd15184    6 LYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDL-LFLLTLPFWAHYAANE-WVFGNAMCKLLTGLYHIGFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLrFKSTKRRAK---IIILVIWIIAFLLALPEVIvadltrFVKRQYIDLLIFCGPQWSDKT 211
Cdd:cd15184   84 SGIFFIILLTIDRYLAIVHAV-FALKARTVTfgvVTSVVTWVVAVFASLPGII------FTKSQKEGSHYTCSPHFPPSQ 156
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 405966368 212 NQV--VYQSVIIVLMYL-LPLVLMTVTYSMIAVVL 243
Cdd:cd15184  157 YQFwkNFQTLKMNILGLvLPLLVMIICYSGILKTL 191
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
61-339 1.53e-10

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 61.45  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVcfAVWR--NRSMRTVTNIFIVNLAIADLA----VIIICLPPTLLSDV----TETWYFGfAMCKIALFLQT 130
Cdd:cd15137   12 IIALLGNLFV--LIWRlkYKEENKVHSFLIKNLAIADFLmgvyLLIIASVDLYYRGVyikhDEEWRSS-WLCTFAGFLAT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRF-KSTKRRAKIIILVIWIIAFLLA-LPEVIVADLTRFVKRQYIDLLIFCGPQ-- 206
Cdd:cd15137   89 LSSEVSVLILTLITLDRFICIVFPFSGrRLGLRRAIIVLACIWLIGLLLAvLPLLPWDYFGNFYGRSGVCLPLHITDErp 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 --WSdktnqvvYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRPMMdgnvnraeeqlesrkkAAKMLITV 284
Cdd:cd15137  169 agWE-------YSVFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAASRKSKRDMA----------------VAKRFFLI 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 285 VIGFAVCYFPVHLfnilryadaLRFVAPRMIQVLSMISHW-----LPyLNSSINPIIYNF 339
Cdd:cd15137  226 VLTDFLCWIPIIV---------IGILALSGVPIPGEVYAWvavfvLP-INSALNPILYTL 275
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
58-300 1.56e-10

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 61.08  E-value: 1.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAM-------CKIALFLQT 130
Cdd:cd15136    9 FVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIdwqtgagCKTAGFLAV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLR--FKSTKRRAKIIILVIWIIAFLLA-LPEVIVADLTRFVkrqyidlliFCGPQW 207
Cdd:cd15136   89 FSSELSVFTLTVITLERWYAITHAMHlnKRLSLRQAAIIMLGGWIFALIMAlLPLVGVSSYSKTS---------ICLPFE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLmYLLPLVLMTVTYSMIAVVlwtgkIPGAIESANRpmmdgnvnraeeqlESRKKAAKMLITVVIG 287
Cdd:cd15136  160 TETPVSKAYVIFLLLF-NGLAFLIICGCYIKIYLS-----VRGSGRAANS--------------NDTRIAKRMALLVFTD 219
                        250
                 ....*....|...
gi 405966368 288 FAvCYFPVHLFNI 300
Cdd:cd15136  220 FL-CWAPIAFFGL 231
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
50-349 1.72e-10

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 61.12  E-value: 1.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFA-VWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTE-TWYFGFAMCKIALF 127
Cdd:cd15170    1 WLVLAVYIITFLIGLPANLLAFYTfIRKVRRKPTPIDILLLNLTVSDL-IFLLFLPFKMAEAASGmIWPLPYFLCPLSSF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 128 LQTTSVAVSVFTLSAISVERWYAICYPLRFKstKRRAKIIILVIWIIAFLLALPE---VIVADLTRFVKRQYIDLLIFCG 204
Cdd:cd15170   80 IFFSTIYISTLFLTAISVERYLGVAFPIKYK--LRRRPLYAVIASVFFWVLAFSHcsiVYIVEYHIDSENTSVTNNSRCY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 PQWSDKTNQVV--YQSVIIVLMYLLPLVLMTVTY-SMIAVVLwtgkipgaiesaNRPmmdgNVNRAEeqlesRKKAAKML 281
Cdd:cd15170  158 DNFTPEQLKILlpVRLELFLVLFCIPFLITCFCYiNFIRILS------------SLP----HISRQR-----KQRAIGLA 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 282 ITVVIGFAVCYFPVHLFNILRYADAlRFVAPRMIQVLsmishwLPYLNSSINPIIYNFMSVQTKGAFH 349
Cdd:cd15170  217 VATLLNFIVCFAPYNISHVVGFIQR-KSPEWRMYALL------LSTLNACLDPIIFYFSSSAVRRAFK 277
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
61-348 2.18e-10

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 60.80  E-value: 2.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVFTL 140
Cdd:cd15298   12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 141 SAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEV-----IVADLTRFVKRQYIDLLifcgpqwsdkTNQ 213
Cdd:cd15298   92 LIISFDRYFCVTKPLTYpaRRTTKMAGLMIAAAWVLSFVLWAPAIlfwqfVVGKRTVPDNQCFIQFL----------SNP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 VVYQSVIIVLMYlLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnvnRAEEqlesrKKAAKMLITVVIGFAVCYF 293
Cdd:cd15298  162 AVTFGTAIAAFY-LPVVIMTVLYIHISLA-----------------------SARE-----RKVTRTIFAILLAFILTWT 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 294 PVHLFNILRyadalRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15298  213 PYNVMVLVN-----TFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
60-346 2.21e-10

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 60.99  E-value: 2.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  60 FIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVFT 139
Cdd:cd15076   11 FIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGWS 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 140 LSAISVERWYAICYPL-RFKSTKRRAKIIILVIWIIAFLLALPEVIvaDLTRFVKRqyiDLLIFCGPQW---SDKTNQVV 215
Cdd:cd15076   91 LAFLAFERYIVICKPFgNFRFGSKHALGAVVATWIIGIGVSLPPFF--GWSRYIPE---GLQCSCGPDWytvGTKYRSEY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 216 YQSVIIVLMYLLPLVLMTVTYSmiavvlwtgKIPGAIESanrpmmdgnVNRAEEQLESRKKA----AKMLITVVIGFAVC 291
Cdd:cd15076  166 YTWFLFIFCFIVPLSIIIFSYS---------QLLGALRA---------VAAQQQESASTQKAerevSRMVVVMVGSFCLC 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 292 YFP-----VHLFNILRYADALRFVAprmiqvlsmISHWLPYLNSSINPIIYNFMSVQTKG 346
Cdd:cd15076  228 YVPyaalaMYMVNNRDHGLDLRLVT---------IPAFFSKSSCVYNPIIYCFMNKQFRA 278
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
53-339 3.01e-10

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 60.55  E-value: 3.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15154    4 LVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDL-LFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQMN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLL--ALPEVIVADLTRFVKRQyiDLLIFCGPQWSDK 210
Cdd:cd15154   83 MYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILggSVPAAIVHSSSDCLLHG--EKVYRCFESFSDN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVII--VLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIEsanrpmmdgnvnraeeqlesRKKAAKMLITVVIGF 288
Cdd:cd15154  161 DWKGLLPLVVLaeILGFLLPLAAVLYCSCRIFVELCRTQEPQQGR--------------------RRKTVRLLLVNLVIF 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 289 AVCYFPVH----LFNILR--YADALRFVAPRMIQVLsMISHWLPYLNSSINPIIYNF 339
Cdd:cd15154  221 LICFVPYNttlaVYGLLRanLVEDTWNIKDTLRKVL-SVTVLLASTNCALDPLVYYF 276
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
54-341 4.05e-10

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 60.20  E-value: 4.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQTTS 132
Cdd:cd15370    5 IVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADL-LFVIWFPLKIAYHINgNNWIYGEALCKVLIGFFYGN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSDKTN 212
Cdd:cd15370   84 MYCSILFMTCLSVQRYWVIVNPMSHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIPALDITTCHDVLPEQLLVGD 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QVVYQSVIIVLMYLLPLVLMTVTYSMIavvlwtgkipgaIESANRPMMDGNVNRaeeqleSRKKAAKMLITVVIGFAVCY 292
Cdd:cd15370  164 MFNYFLSLAIGVFLFPAFLTAVAYVLM------------IRALKSSINDESIEK------KRKRAIKLIVTVLVMYLICF 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 405966368 293 FPVHLFNILRYAdALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15370  226 TPSNLLLVVHYF-LLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVS 273
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
52-339 5.54e-10

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 59.46  E-value: 5.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIClpPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15186    3 LSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATL--PFWTHYLINEWGLHNAMCKLTTAFFFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAI---CYPLRFKsTKRRAKIIILVIWIIAFLLALPEVIvadltrFVKRQYIDLLIFCgPQWS 208
Cdd:cd15186   81 GFFGGIFFITVISIDRYLAIvlaANSMNNR-TVQHGVTISLGVWAAAILVAVPQFM------FTKMKENECLGDY-PEVL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesaNRpmmdgnvnraeeqleSRKKAAKMLITVVIGF 288
Cdd:cd15186  153 QEIWPVLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCK--------NH---------------KKARAIKLILLVVIVF 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 289 AVCYFPvhlFNILRYADALR----FVAPRMIQVLSM---ISHWLPYLNSSINPIIYNF 339
Cdd:cd15186  210 FLFWTP---YNVMIFLETLKlydfFPSCDMKKDLRLalsVTETIAFSHCCLNPLIYAF 264
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
66-239 7.14e-10

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 59.18  E-value: 7.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  66 GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVFTLSAISV 145
Cdd:cd15214   16 GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 146 ERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIdllifCGPQWSdktNQVVYQSVIIVL 223
Cdd:cd15214   96 DRYYAVLYPMVYpmKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEFDRFKWM-----CVAAWH---KEAGYTAFWQVW 167
                        170
                 ....*....|....*.
gi 405966368 224 MYLLPLVLMTVTYSMI 239
Cdd:cd15214  168 CALLPFVVMLVCYGFI 183
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
52-337 1.00e-09

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 58.50  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15300    3 IAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIVADLtrFVKRQYIDLlifcgpqwSD 209
Cdd:cd15300   83 ASNASVMNLLVISFDRYFSITRPLtyRAKRTPKRAGIMIGLAWLISFILWAPPILCWQY--FVGKRTVPE--------RE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVII----VLMYLLPLVLMTVTYSmiavvlwtgkipgaiesanrpmmdgnvnRAEEQLESRKKAAKMLITVV 285
Cdd:cd15300  153 CQIQFLSEPTITfgtaIAAFYIPVSVMTILYC----------------------------RIYKETIKERKAAQTLSAIL 204
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 405966368 286 IGFAVCYFPvhlFNILRYADAlrFVAPRMIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15300  205 LAFIITWTP---YNIMVLVST--FCSDCIPLTLWHLGYWLCYVNSTVNPMCY 251
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
55-337 1.65e-09

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 58.28  E-value: 1.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMR---TVTNIFIVNLAIADLAVIIIClpPTLLSDV--TETWYFGFAMCKIALFLQ 129
Cdd:cd15338    6 VFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGM--PFLIHQLlgNGVWHFGETMCTLITALD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQw 207
Cdd:cd15338   84 TNSQITSTYILTVMTLDRYLATVHPIRSTKirTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVGCALLLPNPE- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQsviIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESAnrpmmdgnvnraeeQLESrKKAAKMLITVVIG 287
Cdd:cd15338  163 TDTYWFTLYQ---FFLAFALPLVVICVVYFKILQNMASTVAPLPQRSL--------------RVRT-KKVTRMAVAICLA 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 405966368 288 FAVCYFPVHLFNILRYADALRFVAprmIQVLSMISHWLPYLNSSINPIIY 337
Cdd:cd15338  225 FFICWAPFYILQLAHLSIDRPSLA---FLYAYNVAISMGYANSCINPFLY 271
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
52-337 1.88e-09

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 57.93  E-value: 1.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLS--GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15404    1 VILSAVMIFILLVSflGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERwYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRqyidllifcGPQ--W 207
Cdd:cd15404   81 WLFVMEGVAILLIISIDR-FLIIVQKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDLQIPSR---------APQcvF 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgNVNRAeeqleSRKKAAKMLITVVIG 287
Cdd:cd15404  151 GYTTNPGYQAYVILIMLIFFFIPFMVMLYSFMGIL--------------------NTVRS-----FKTRAFTTILILFIV 205
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 405966368 288 FAVCYFPVHLFNILRYADALRFVAPRMIQVlSMISHWLPYLNSSINPIIY 337
Cdd:cd15404  206 FTVCWAPFTTYSLVATFNSHFYHKHNFFEI-STWLLWLCYLKSALNPLIY 254
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
52-162 2.92e-09

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 57.44  E-value: 2.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTN-IFIVNLAIADLAVIIIcLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd14983    3 SLMVYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDLVFILS-LPIKIVEALSSAWTLPAVLCPLYNLAHF 81
                         90       100       110
                 ....*....|....*....|....*....|..
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKR 162
Cdd:cd14983   82 STLYASTCFLTAISAGRYLGVAFPIKYQLYKK 113
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
52-348 2.97e-09

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 57.16  E-value: 2.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIvglsGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15215    6 IVIFLCASLF----GNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYidlliFCGPQWSD 209
Cdd:cd15215   82 FAFAGVNTIVVVSVDRYLAIIHPLSYptKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDERNA-----LCSVIWGS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNqvvYQSVIIVLMYLLPLVLMTVTYSMiavvlwtgkipgaiesanrpmmdgnVNRAEEQLeSRKKAAKMLITVVIGFA 289
Cdd:cd15215  157 SYS---YTILSVVSSFVLPVIIMLACYSM-------------------------VFRAARRC-YHCKAAKVIFIIIFSYV 207
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 290 VCYFPVHLFNILR-YADAlrfvapRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15215  208 LSMGPYSFLSVLAvWVDT------QVPQWVISIILWLFFLQCCIHPYIYGYMHKSIKKEF 261
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
61-294 4.61e-09

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 56.76  E-value: 4.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVFTL 140
Cdd:cd15080   12 LLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 141 SAISVERWYAICYPL-RFKSTKRRAKIIILVIWIIAFLLALPEVIvaDLTRFVKRqyiDLLIFCGPQWSDKTNQVVYQSV 219
Cdd:cd15080   92 VVLAIERYVVVCKPMsNFRFGENHAIMGVAFTWVMALACAAPPLV--GWSRYIPE---GMQCSCGIDYYTLKPEVNNESF 166
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 220 II---VLMYLLPLVLMTVTYSMIavvLWTGKipgaiESANRPMMDGNVNRAEeqlesrKKAAKMLITVVIGFAVCYFP 294
Cdd:cd15080  167 VIymfVVHFTIPLIVIFFCYGRL---VCTVK-----EAAAQQQESATTQKAE------KEVTRMVIIMVIAFLICWVP 230
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
57-342 5.22e-09

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 56.70  E-value: 5.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  57 ALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDV-TETWYFGFAMCKIALFLQTTSVAV 135
Cdd:cd15200    8 GIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADF-FLIINLPFRIDYYLrNEVWRFGATACQVNLFMLSMNRTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 136 SVFTLSAISVERWYAICYP---LRFKSTKRRAKIIILVIWIIAFL---LALPEVIVADLTRFVKRQYIDllifcgPQWSD 209
Cdd:cd15200   87 SIVFLTAIALNRYLKVVHPhhqLSKASVGCAAKVAAGLWILILLLnihLLLLDHVQSNSTCLSYDHGTD------PSASD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYqsviiVLMYLLPLVLMTVTysmIAVVLWTGKipgaiesaNRPMMDGNVNRaeeqlesrkKAAKMLITVVIGFA 289
Cdd:cd15200  161 RWHRILF-----FLEFFLPLGIILFC---IFSIILTLK--------QRKLAKQAGPQ---------RAVKVLAVIVLVYT 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 290 VCYFPVHLFNILRYAdALRFVAPRMIQVLSMISHW---LPYLNSSINPIIYNFMSV 342
Cdd:cd15200  216 VCFLPSILFALASLV-AFKVSQCRSLDLCTQLFHGslaFTYLNSALDPVLYCFSSP 270
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
61-348 6.37e-09

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 56.48  E-value: 6.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIF-IVNLAIADLAV----IIICLPPTLLSD----VTETWYFGFaMCKIALFLQTT 131
Cdd:cd14980   12 ILALIGNILVIIWHISSKKKKKKVPKLlIINLAIADFLMgiylLIIAIADQYYRGryaqYSEEWLRSP-PCLLACFLVSL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS-TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIfCGPQWSDK 210
Cdd:cd14980   91 SSLMSVLMMLLITLDRYICIVYPFSNKRlSYKSAKIILILGWLFSIIFAAIPILYSINQPGDNRLYGYSSI-CMPSNVSN 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYqSVIIVLMYLLPLVLMTVTYS-MIAVVLWTGKipgaiesanrpmmdgNVNRAEEQLEsrKKAAKMLITVVIGFA 289
Cdd:cd14980  170 PYYRGW-LIAYLLLTFIAWIIICILYIlIFISVRKSRK---------------SARRSSSKRD--KRIAIRLALILITDL 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 290 VCYFPVHLFNILryadalrfvapRMIQVLSMISHWLPY-------LNSSINPIIYNFMSVQTKGAF 348
Cdd:cd14980  232 ICWLPYYIVIFS-----------GLLTSTEIDIHVLQFiailalpLNSAINPYLYTLTTPTFKRDF 286
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
61-348 7.30e-09

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 56.28  E-value: 7.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVFTL 140
Cdd:cd15086   12 TFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSLISL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 141 SAISVERWYAICYPLRFKSTK-RRAKIIILVIWIIAFLLALPEvivadLTRFVKRQYIDLLIFCGPQWSDKT-NQVVYQS 218
Cdd:cd15086   92 AVLSYERYCTLLRPTEADVSDyRKAWLGVGGSWLYSLLWTLPP-----LLGWSSYGPEGPGTTCSVQWTSRSaNSISYII 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 219 VIIVLMYLLPLVLMTVTYsmiavvlwtGKIPGAIESANRpmMDGNVNRAEEQlesrkKAAKMLITVVIGFAVCYFPVHLF 298
Cdd:cd15086  167 CLFIFCLLLPFLVMVYCY---------GRLLYAIKQVGK--INKSTARKREQ-----HVLLMVVTMVICYLLCWLPYGVM 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 405966368 299 NILRYADALRFVAPrmiqVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15086  231 ALLATFGKPGLVTP----VASIVPSILAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
54-302 7.43e-09

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 56.31  E-value: 7.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLavIIICLPPTLLSDVTE--TWYFGFAMCKIALFLQTT 131
Cdd:cd15367    5 VVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADL--LYIFSLPFWLQYVLQhdNWTYSELLCKICGILLYE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFkSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLIFCGPQWSDKT 211
Cdd:cd15367   83 NIYISIGFLCCISVDRYLAVVHPFRF-HAFRTMKAATLVSTVIWLKELMTCVFFFLHGEISKDKENHSVCFEHYPIKAWE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVIIvlMYLLPLVLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnVNRAEEQLESRKKAAKMLITV-VIGFAV 290
Cdd:cd15367  162 HNINYYRFYA--GFLFPIFLLSFSYCRILRA---------------------VRKSHGTQKSQKIQIKRLVLStVVIFLV 218
                        250
                 ....*....|..
gi 405966368 291 CYFPVHLFNILR 302
Cdd:cd15367  219 CFGPYHILLLVR 230
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
59-339 8.42e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 56.15  E-value: 8.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  59 TFIVGLsgNVLVCFAVWRNRSMRTVTNIFIVNLAIADL----AVIIICLPPTLLSDVTETWYFGFAMCKIALflqttSVA 134
Cdd:cd14972   10 VFIVVE--NSLVLAAIIKNRRLHKPMYILIANLAAADLlagiAFVFTFLSVLLVSLTPSPATWLLRKGSLVL-----SLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALpevivadLTRFVKRQYIDLLIFCGPQWSDKTN 212
Cdd:cd14972   83 ASAYSLLAIAVDRYISIVHGLTYVNnvTNKRVKVLIALVWVWSVLLAL-------LPVLGWNCVLCDQESCSPLGPGLPK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 QVVyqsVIIVLMYLLPLVLMTVTYSMIAVVLWTgkipgaieSANRPMMDGNVNRAEEQLESRKKAAKMLITVVIgFAVCY 292
Cdd:cd14972  156 SYL---VLILVFFFIALVIIVFLYVRIFWCLWR--------HANAIAARQEAAVPAQPSTSRKLAKTVVIVLGV-FLVCW 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 405966368 293 FPvhlFNILRYADALRFvAPRMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd14972  224 LP---LLILLVLDVLCP-SVCDIQAVFYYFLVLALLNSAINPIIYAF 266
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
52-339 9.67e-09

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 55.84  E-value: 9.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVgLSGNVLVCFAVWR-NRSMRTVTNIFIVNLAIADLAV---IIICLPPTLLSDVTETWYFgfaMCKIALF 127
Cdd:cd15104    3 GVILAVLSPLI-ITGNLLVIVALLKlIRKKDTKSNCFLLNLAIADFLVglaIPGLATDELLSDGENTQKV---LCLLRMC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 128 LQTTSVAVSVFTLSAISVERWYAICYPLRFK--STKRRAKIIILVIWIIAFLLALPEVIVADLtrfvkrQYIDLLIFCGp 205
Cdd:cd15104   79 FVITSCAASVLSLAAIAFDRYLALKQPLRYKqiMTGKSAGALIAGLWLYSGLIGFLPLISPQF------QQTSYKGKCS- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 qwsdkTNQVVYQSVIIVL--MYLLP--LVLMTVTYSMIAVVLWTGKIPGAIESAnrpmMDGNVNRAeeQLESRKKAAKML 281
Cdd:cd15104  152 -----FFAAFHPRVLLVLscMVFFPalLLFVFCYCDILKIARVHSRAIYKVEHA----LARQIHPR--RTLSDFKAARTV 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 282 ITVVIGFAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHwlpyLNSSINPIIYNF 339
Cdd:cd15104  221 AVLIGCFLLSWLPFQITGLVQALCDECKLYDVLEDYLWLLGL----CNSLLNPWIYAF 274
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
55-348 1.28e-08

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 55.41  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVA 134
Cdd:cd15420    6 LFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAH 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYID---------LLIFC 203
Cdd:cd15420   86 TECVLLAVMSYDRYVAICHPLRYTVimNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNhffceilavLKLAC 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 GPQWSDKtnqvVYQSVIIVLMYLLPLVLMTVTYSMIavvLWTGKipgAIESAnrpmmdgnvnraeeqlESRKKAakmlit 283
Cdd:cd15420  166 ADTWINE----ILIFAGCVFILLGPFSLILISYLHI---LAAIL---KIQSA----------------EGRRKA------ 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 284 vvigFAVCYfpVHLFNI-LRYADA-LRFVAPRMIQV---LSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15420  214 ----FSTCS--SHLCVVgLFYGTAmFMYMVPGSSNSaeqEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
42-341 1.49e-08

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 55.17  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  42 YVFPddwewgiiILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAM 121
Cdd:cd15365    1 YLFP--------FVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFV 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 122 CKIALFLQTTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLli 201
Cdd:cd15365   73 CIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSFHESSSHTL-- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 202 fCGPQWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSmiavvlwtgKIPGAIESanrpmmdgnvNRAEEQLEsRKKAAKML 281
Cdd:cd15365  151 -CYDKFPLEDWQARLNLFRICLGYLLPLLIILFCYW---------KIYQAVRS----------NQATEDQE-KKKIFKLL 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 282 ITVVIGFAVCYFPVHLFNILR--YADALRFVAPRMIQvLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15365  210 LLITVTFVICFTPYHVVLLIRsiVEPCDCRNAKWLYT-LYKITVALTSLNCIADPFLYCFVT 270
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
54-339 1.57e-08

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 55.10  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLavIIICLPP----TLLSDvtETWYFGFAMCKIALFLQ 129
Cdd:cd15157    5 TVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDL--MFVSTLPfradYYLMG--SHWVFGDIACRIMSYSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIiaFLLALPEVIVADLTRFVKRQYIDLlifcGPQW 207
Cdd:cd15157   81 YVNMYCSIYFLTVLSIVRFLAIVHPFKLWKvtSIKYARILCAVIWI--FVMAASSPLLSKGTSKYNSQTKCL----DLHP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 SDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPgaiESANRPmmdgnvnraeeqleSRKKAAKMLITVVIG 287
Cdd:cd15157  155 SKIDKLLILNYIVLVVGFILPFCTLSICYILIIKALLKPRVP---QSKLRV--------------SHKKALLTIIITLIL 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 405966368 288 FAVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNF 339
Cdd:cd15157  218 FLLCFLPYHILRTVHLMQWSEGQCNLRLHKAVVITLCLAAANSCLDPLLYYF 269
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
60-340 2.22e-08

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 54.83  E-value: 2.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  60 FIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLlsDVTETWYFGFAMCK-IALFLQTTSVAvSVF 138
Cdd:cd14989   11 FPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVF--NLNEKYYDIAVLCTfMSLFLQINMYS-SIF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 139 TLSAISVERWYAI-----CYPLRfksTKRRAKIIILVIWIIAFLLALPEVIVadltrfVKRQYIDLLIFCGPQWSDktnq 213
Cdd:cd14989   88 FLTWMSFDRYIALakvmkSSPLR---TMQHARLSCGLIWMASISATLLPFTA------VQAQHTGEVHFCFADVRE---- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 214 vvYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIesanRPmmdgnvnraeeqleSRKKAAKMLITVVIGFAVCYF 293
Cdd:cd14989  155 --IQWLEVTLGFIIPFSIIGLCYSLIVRVLVRAQKHRRL----RP--------------RRQKALRMILVVVLVFFICWL 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 294 PVHLF-----------NILRYADALRFVAPRMIQVLSMIShwlpYLNSSINPIIYNFM 340
Cdd:cd14989  215 PENVFisiqllqgtqePSESYDESFRHNHPLTGHIVNLAA----FSNSCLNPLIYSFL 268
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
53-297 2.27e-08

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 54.65  E-value: 2.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTEtWYFGFAMCKIALFLQTTS 132
Cdd:cd15165    4 LVVYIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDL-LLLLSLPFKMHSSKKQ-WPLGRTLCSFLESLYFVN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPevivadltRFVKRQYIDLLIFCGPQWSDK 210
Cdd:cd15165   82 MYGSILIIVCISVDRYIAIRHPFLAKRlrSPRKAAIVCLTIWVFVWAGSIP--------IYSFHDKPTNNTRCFHGFSNK 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVvyqSVIIVLM---YLLPLVLMTVTYSMIAVVLWTGKIPgaiesanrpmmdgnvnraEEQLESRKKAAKMLITVVIG 287
Cdd:cd15165  154 TWSK---KVIVVVEefgFLIPMAVMVFCSVQIIRTLLDMRRP------------------EQPKVKQNKSVKIVLSNLVV 212
                        250
                 ....*....|
gi 405966368 288 FAVCYFPVHL 297
Cdd:cd15165  213 FLVCFTPYHL 222
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
61-341 6.41e-08

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 53.29  E-value: 6.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSVFTL 140
Cdd:cd15078   12 FLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIVSIMTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 141 SAISVERWYAICYP--LRFKSTKRrakiiiLVIWIIAFLLALPEVIVADLTRFVKRQYidlLIFCGPQWSDK-TNQVVYQ 217
Cdd:cd15078   92 TVLAYERYIRVVHAkvVNFSWSWR------AITYIWLYSLAWTGAPLLGWNRYTLEVH---GLGCSFDWKSKdPNDTSFV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 218 SVIIVLMYLLPLVLMTVTYSMIavvLWTGKIPGAIEsanrpmmDGNVNRAEEQLESRKKAAKMLITVVIGFAVCYFPVHL 297
Cdd:cd15078  163 LLFFLGCLVVPLGIMAYCYGHI---LYEIRMLRSVE-------DLQTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAV 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 405966368 298 FNILRYADALRFVAPrmiqVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15078  233 VSLLVTSGYSKLVTP----TIAIIPSLFAKSSTAYNPVIYIFMI 272
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
54-345 7.65e-08

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 53.06  E-value: 7.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15223    5 LPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYID---------LLIF 202
Cdd:cd15223   85 AMESSILLVMALDRYVAICKPLRYPSiiTKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEhcycdhmalVSLA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 203 CGpqwsDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanrpmmdgnvnRAEEQLESRKKAAKMLI 282
Cdd:cd15223  165 CG----DTTINSIYGLAVAWLIVGSDIILIFFSYALIL-------------------------RAVLRLASGEARSKALN 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 283 TVVIGFAV--CYFPVHLFNILRYAdaLRFVAPRMIQVLSMISHWLpyLNSSINPIIYnfmSVQTK 345
Cdd:cd15223  216 TCGSHLIVilFFYTAVLVSSLTYR--FGKTIPPDVHVLLSVLYIL--IPPALNPIIY---GVRTK 273
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
54-341 7.81e-08

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 53.26  E-value: 7.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPptlLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15920    5 VMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADL-LLVLCLP---FRVAYQNTAGPLSFCKIVGAFFYLNM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPL-RFK-STKRRAKIIILVIWIIAFLLALPEVivadltrFVKRQYIDLLIFCGPQWSDKT 211
Cdd:cd15920   81 YASILFLSLISLDRYLKIIKPLqQFKiHTVPWSSAASGGVWLLLLACMIPFL-------FESRNEGPCDNKCFHFRSKGL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQVVYQSVIIVLMYLLpLVLMTVTYSMIAVVLWtgkipgaiesanrpmmDGNVNRAEEQ-LESRKKAAKMLITVVIGFAV 290
Cdd:cd15920  154 TAGGINLTAVVIFYIL-SLLFLYFYAKISHKLY----------------KVSLGNAQQQiKKASKRAIIKTFIVLAIFIV 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 291 CYFPVHLFNILRYADALRFVA----PRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15920  217 CFVPYHIVRVPYVLAQIDVISslpwKQTLHIANELVLCLSALNSCLDPIIYFFLS 271
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
53-341 7.88e-08

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 53.03  E-value: 7.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLvcfAVW----RNRSmRTVTNIFIVNLAIADLAVIIIC----------LPPTLLSDVTETWYFg 118
Cdd:cd15164    4 LIIYIPILFFGLLFNVL---ALWvfccKMKK-WTETRVYMINLAVADCCLLFSLpfvlyflkhsWPDDELCLVLQSIYF- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 119 famckialflqtTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAkiiilvIWIIAFLLALpeVIVADLTRFVKRQY 196
Cdd:cd15164   79 ------------INRYMSIYIITAIAVDRYIAIKYPLKAKSlrSPRKA------ALTCGLLWVL--VIISVSLRLAWEEQ 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 197 IDLLIFcgpqWSDKTNQVVYQSVIIVLMYLLPLVlmTVTYSMIAVvlwtgkipgaIESANRPMmdgNVNRAEEQLesRKK 276
Cdd:cd15164  139 EENFCF----GKTSTRPSKRTLIFSLLGFFIPLI--ILSFCSIQV----------IRSLKKKK---KTNPHEEKL--IQK 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 277 AAKMLITVVIGFAVCYFPVHLFNILRYADALRFVAPRMIQVLSM---ISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15164  198 AIYIVSANLIVFIVCFLPLHIGLLVRFVMESNKASCSLIQNIRNfiyVASCLANANCCLDAICYYFVA 265
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
54-341 8.58e-08

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 53.22  E-value: 8.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNvlvCFAVWRNRSMRTVTN-----IFIVNLAIADLaVIIICLPPTLLSDVTE-TWYFGFAMCKIA-- 125
Cdd:cd15147    5 IVYSIIFVLGLIAN---CYVLWVFARLYPSKKlneikIFMVNLTIADL-LFLITLPFWIVYYHNEgNWILPKFLCNVAgc 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 126 LFLQTTSVavSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLL--ALPeVIVADLTRFVKRQYIDLL-IF 202
Cdd:cd15147   81 LFFINTYC--SVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVasASY-FLFMDSTNTVKIDSGNFTrCF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 203 CGPQWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLwtgkipgaiesanRPMMDGNVNRaeeqlESRKKAAKMLI 282
Cdd:cd15147  158 EGYEKDNSKPVLIIHFIIIGLFFLVFLLILVCNLVIARTLL-------------SQPVQGQRNA-----GVKRRALWMVC 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 283 TVVIGFAVCYFPVHL------FNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15147  220 TVLAVFVICFVPHHVvqgpwtLAVLQQWRYWDCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLT 284
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
53-341 1.60e-07

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 52.26  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIV---GLSGNVLV----CFAVWRNRSMrtvtnIFIVNLAIADLAV----IIICLPPTLLsdvteTWYFGFAM 121
Cdd:cd14973    1 LVIFSLTVLLslcGLVGNGLVlwllGFRIKRNPFS-----VYILNLAAADFLFlscqAIQSLEDLLG-----GSLPGFAL 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 122 CKIALFLQTTSVAVSVFTLSAISVERWYAICYPLRFKStkRRAKIIILVIWIIAFLLALPEVIVadltrfvkrqyidLLI 201
Cdd:cd14973   71 CRLLATLMFFSYTVGLSLLAAISTERCLSVLFPIWYRC--HRPKHLSAVVCALLWALSLLLSVL-------------ESY 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 202 FCG-PQWSDKTNQVVYQSVIIVLMYLLPLVLMTVtySMIAVVLWtgkipgaiesanrpmmdgnVNRAEEQLESRKKAAKM 280
Cdd:cd14973  136 FCGfLFWKFNESACRTFNFLSALLFLLLFLVMCV--SSLTLLIR-------------------VQCSSQRRPPTRLYVVI 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 281 LITVVIgFAVCYFPVHLFNILRYAdalrfVAPRMIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd14973  195 LLTVLV-FLLCGLPLGIYWFLLLW-----FSNYLFHTFHPISDLLSCVNSSANPIIYFFVG 249
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
54-340 1.63e-07

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 52.12  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLvcfAVWRNRSMRTVTN--IFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQT 130
Cdd:cd15150    5 LLYTVLFIVGLTMNGL---AMRVFFQIPSKSNfiIFLKNTVISDL-LMILTFPFKILSDAKlGSWPLRGFVCQVTSVIFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKR--RAKIIILVIWIIAFLLALPEVIVADLTRFVK--RQYIDLLIFCGPQ 206
Cdd:cd15150   81 FTMYISILFLGLITIDRYQKTTRPFKTSNPKNllGAKILSTVIWASMFALSLPNMILTNRQPTPKnvKKCSLLKSEFGLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQvvyqsvIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanRPMMDGNVNRAEEQLESRKKAAKMLITVVI 286
Cdd:cd15150  161 WHEIVNY------ICQVIFWVNFLIVIVCYTLIT----------------KELYKSYKRTRGVGKVSRKKVNVKVFIIIA 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 287 GFAVCYFPVHL----FNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15150  219 VFFICFVPFHFaripYTLSQTRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFL 276
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
52-348 2.26e-07

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 51.64  E-value: 2.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLsgnVLVCFAVW----RNRSMRTVTnIFIVNLAIADlAVIIICLPPTLL-SDVTETWYFGFAMCKIAL 126
Cdd:cd15922    3 IPVFLSLVFLGGF---LLNSFSLWifwfRIKQWSSGT-ILQFNLALSD-AIITPAAPLLIAyFSLGSHWPFGQFLCQLKV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRA--KIIILVIWIIAFLLALPevivadLTRFVKRQYIDLLIFCG 204
Cdd:cd15922   78 FLLSTHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSfmKKLCLGVWLLLFVQGLP------FFFVLKTSVIDGKTKCL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 PQWSDKTNQV--VYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipGAIESANrpmmdgnvnraeeQLESRKKAAKMLI 282
Cdd:cd15922  152 SIHQSELSLLyfVWNFVLLILGFLLPFGVSLTCYALLG---------ASIAKMN-------------SNNARGRAMKAKS 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 283 TVVIG-----FAVCYFPVHLFN----ILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15922  210 LQMIGislviFIICFVPLHVTRtvgvVVKLFYPESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
61-180 2.65e-07

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 51.44  E-value: 2.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAM-------CKIALFLQTTSV 133
Cdd:cd15964   12 LLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIdwqtgpgCNTAGFFTVFAS 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLAL 180
Cdd:cd15964   92 ELSVYTLTVITLERWYAITFAMRLdrKIRLRHASAIMLGGWVFCFLLAL 140
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
52-348 2.79e-07

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 51.83  E-value: 2.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVtNIFIVNLAIADLaVIIICLPPTLLSDVTEtWYFGFAMCKIALFLQTT 131
Cdd:PHA02834  31 VIVFYILLFIFGLIGNVLVIAVLIVKRFMFVV-DVYLFNIAMSDL-MLVFSFPFIIHNDLNE-WIFGEFMCKLVLGVYFV 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIW-IIAFLLALPEVIvadLTRFVKRQYIDLLIFCGPQwSDK 210
Cdd:PHA02834 108 GFFSNMFFVTLISIDRYILVVNATKIKNKSISLSVLLSVAAwVCSVILSMPAMV---LYYVDNTDNLKQCIFNDYH-ENF 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKipgaiesanrpmmdgNVNRAeeqlesrkKAAKMLITVVIGFAV 290
Cdd:PHA02834 184 SWSAFFNFEINIFGIVIPLIILIYCYSKILYTLKNCK---------------NKNKT--------RSIKIILTVVTFTVV 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 291 CYFPvhlFNILRYADALRFVA------------PRMIQVLSMIShwlpYLNSSINPIIYNFMSVQTKGAF 348
Cdd:PHA02834 241 FWVP---FNIVLFINSLQSVGlidigcyhfkkiVYSIDIAELIS----FVHCCVNPIIYAFVGKNFKKVF 303
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
52-347 4.02e-07

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 50.95  E-value: 4.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15233    3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTRF-----VKRQYIDLLIFCg 204
Cdd:cd15233   83 LAGADCFLLTAMAYDRYLAICQPLTYSVrmSWRVQTALVGISCACAFTNALTHTVAMSTLKFcgpnvINHFFCDLPPLF- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 pQWSDKTNQVVYQS--VIIVLMYLLPLVLMTVTYSMIAVVLWTgkipgaIESAnrpmmdgnvnraeeqlESRKKA----A 278
Cdd:cd15233  162 -QLSCSSTHLNELLlfVFAFFMALAPCVLIVVSYAHVVAAVLR------IRSA----------------EGRRKAfstcG 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 279 KMLITVVIgfavcYFPVHLFNILRYADALRFVAPRMIQVLSMIshwlpyLNSSINPIIYNFMSVQTKGA 347
Cdd:cd15233  219 SHLTVVCI-----FYGTGVFSYMRLGSVYSSDKDKVIGILNTV------LSPMLNPLIYSLRNKDVKGA 276
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
54-157 4.09e-07

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 50.91  E-value: 4.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTF----IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15227    1 ILHFVLFlliyLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLF 80
                         90       100
                 ....*....|....*....|....*...
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRF 157
Cdd:cd15227   81 IFFAASELALLTVMAYDRYVAICHPLHY 108
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
52-341 4.90e-07

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 50.56  E-value: 4.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRnRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQT 130
Cdd:cd15371    3 IPAVYIIVVVLGVPSNAIILWMLFF-RLRSVCTAIFYANLAISDL-LFCITLPFKIVYHLNgNNWVFGETMCRIITITFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRR--AKIIILVIWIIAFLLALPEVIVADlTRFVKRQYIDLLIFCGPQWS 208
Cdd:cd15371   81 GNMYCSILLLTCISINRYLAIVHPFIYRSLPKKtyAVLICALVWTIVFLYMLPFFILKQ-TYYLKELNITTCHDVLPECE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTN-QVVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanrpmmdgnvnRAEEQLESRK-KAAKMLITVVI 286
Cdd:cd15371  160 QNSNfQFYYFISMAVFGFLIPLVITIFCYISII-------------------------RTLNAYEHKWfWYVKITALVLI 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 287 GFAVCYFPVHLFNILRYADALRFVAPRMIQvLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15371  215 IFTICFAPSNVILIIHHFNYYYFNNDNLYS-IYLIALCLGSLNSCLDPFLYFLMS 268
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
54-205 4.94e-07

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 50.74  E-value: 4.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15224    5 LLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLA 84
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKSTKRRAkiiilviwiIAFLLALPEVIVADLTRFVKRQYIDLLIFCGP 205
Cdd:cd15224   85 CTECVLLAVMAYDRYVAICHPLRYPVIMTHQ---------LCVQLAAGSWLSGFLISMIKVYFISQLSFCGP 147
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
52-159 5.58e-07

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 50.49  E-value: 5.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVtetWY----FGFAMCKIALF 127
Cdd:cd15950    3 IAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDL-VMSTSIVPKMLSIF---WLgsaeISFEACFTQMF 78
                         90       100       110
                 ....*....|....*....|....*....|..
gi 405966368 128 LQTTSVAVSVFTLSAISVERWYAICYPLRFKS 159
Cdd:cd15950   79 FVHSFTAVESGVLLAMAFDRYVAICHPLRYSA 110
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
54-343 6.83e-07

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 50.24  E-value: 6.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFI---VGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15085    2 ILSFLMFLnatFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPL-RFKSTKRRAKIIILVIWIIAFLLAlpeviVADLTRFVKRQYIDLLIFCGPQWSD 209
Cdd:cd15085   82 YFGIVSLWSLTLLAYERYNVVCKPMgGLKLSTKRGYQGLLFIWLFCLFWA-----VAPLFGWSSYGPEGVQTSCSIGWEE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KT-NQVVYQSVIIVLMYLLPLVLMTVTYSmiAVVLWTGKIPGAIESanrpmmDGNVNRAEEQlesrKKAAKMLITVVIGF 288
Cdd:cd15085  157 RSwSNYSYLILYFLMCFVIPVAIIGFSYG--NVLRSLHKLNKKIEQ------QGGKNCPEEE----ERAVIMVLAMVIAF 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPrmiqVLSMISHWLPYLNSSINPIIYNFMSVQ 343
Cdd:cd15085  225 LICWLPYTVFALIVVVNPELSISP----LAATMPTYFAKTSPVYNPIIYIFLNKQ 275
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
58-348 9.38e-07

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 49.66  E-value: 9.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGN-VLVCFAVWRNRSMRTVTnIFIVNLAIADLaVIIICLPptLLSDV---TETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15201    9 LEFVLGLLGNgLALWIFCFHLKSWKSST-VYLFNLAVADF-LLIICLP--FRTDYylrGKHWKFGDIPCRIVLFMLAMNR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYP---LRFKSTKRRAKII----ILVIWIIAFLLALPEVIVadltrFVKRQYIDLLIFCGPQ 206
Cdd:cd15201   85 AGSIFFLTAVAVDRYFRVVHPhhrINSISVRKAAIIAcglwLLTIAMTVYLLTKKHLFP-----RGNATQCESFNICTGT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDktnqVVYQSVIIVLMYLLPLVlmTVTYSMIAVVlWTGKipgaiesanrpmmdgnvNRAEEQLESRKKAAKMLITVVI 286
Cdd:cd15201  160 DSS----SNWHEAMFLLEFFLPLA--IILYCSVRII-WQLR-----------------GRQLDRHAKIKRAVQFIMVVAI 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 287 GFAVCYFP-----VHLFnILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15201  216 VFIICFLPsnvtrIAIW-ILKHTSNEDCQYYRSVDLAFYITISFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
52-239 1.01e-06

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 49.81  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTL---LSDVTEtwyFGFAMCKIAL-F 127
Cdd:cd15222    3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLgifWFNARE---ISFDACLAQMfF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 128 LQTTSVAVSVfTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIvadltrFVKRqyidlLIFCGP 205
Cdd:cd15222   80 IHTFSFMESS-VLLAMAFDRFVAICNPLRYASilTNSRIAKIGLAIVLRSVLLLLPLPF------LLKR-----LPFCHS 147
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 Q----------------WSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMI 239
Cdd:cd15222  148 NvlshsyclhqdvmklaCSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLI 197
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
52-159 1.10e-06

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 49.77  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15955    3 IGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHT 82
                         90       100
                 ....*....|....*....|....*...
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS 159
Cdd:cd15955   83 LQAFESGILLAMALDRYVAICHPLRHSS 110
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
53-153 1.56e-06

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 49.56  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLS-DVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15217    4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSiRNGSAWTYSVLSCKIVAFMAVL 83
                         90       100
                 ....*....|....*....|..
gi 405966368 132 SVAVSVFTLSAISVERWYAICY 153
Cdd:cd15217   84 FCFHAAFMLFCISVTRYMAIAH 105
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
54-340 2.04e-06

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 48.98  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLvcfAVWRNRSMRTVTN--IFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQT 130
Cdd:cd15924    5 VLYTVIFFAGILLNGL---AMWIFFHIPSKSSfiIYLKNTVVADL-LMILTFPFKILSDAGlGPWQLRTFVCRVTSVLFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRR--AKIIILVIWIIAFLLALPEVIVAdltrfvKRQYIDLLIFCGPQWS 208
Cdd:cd15924   81 FTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVsfAKILSVVVWALMFLLSLPNMILT------NQQPREKNVKKCSFLK 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSV--IIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRpmmdgnvnraeeqlesRKKAAKMLITVVI 286
Cdd:cd15924  155 SELGLKWHEIVnyICQVIFWIVFLLMIVCYTAITKKVYRSYRRVFRSSSSR----------------RKKSNVKIFIIVA 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 287 GFAVCYFPVHLFNI---LRYADALRFV-APRMIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15924  219 VFFVCFVPYHFARIpytLSQTRDVFDCtAENILFYVKEATLFLSALNVCLDPIIYFFL 276
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
58-157 3.00e-06

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 48.25  E-value: 3.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSV 137
Cdd:cd15912    9 LTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEF 88
                         90       100
                 ....*....|....*....|
gi 405966368 138 FTLSAISVERWYAICYPLRF 157
Cdd:cd15912   89 FLLAVMSFDRYVAICNPLHY 108
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
55-343 3.32e-06

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 48.22  E-value: 3.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIIcLPPTLLSDVT-ETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15369    6 VYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLL-LPFKIAYHFSgNDWLFGEAMCRVVTAAFYCNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPeVIVADLTRFVKRQYIdllIFCGPQWSDKT 211
Cdd:cd15369   85 YCSILLMTCISVDRFLAVVYPMQSLSwrTLRRASFTCAAIWLLSIAGVVP-LLLSEQTIQIPDLGI---TTCHDVLNEQL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 212 NQ---VVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWTGKIPGaiesanrpmmdgnvNRAEeqlesRKKAAKMLITVVIGF 288
Cdd:cd15369  161 LMgyyVYYFSIFSCLFFFVPLIITTVCYVSIIRCLSSSSDVA--------------NSSK-----KTRALFMAVAVFCVF 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 289 AVCYFPVHLFNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQ 343
Cdd:cd15369  222 VICFGPTNVLLLAHYVRFAYTSTNDASYFAYLLCVCVGSISCCLDPLIYYYGSSQ 276
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
52-239 3.64e-06

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 48.06  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLsdvteTWYFG-----FAMCKIAL 126
Cdd:cd15221    3 ISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLA-----IFWFGageisFDGCLTQM 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLAlpevIVADLTRFVKRqyidlLIFCGPQ 206
Cdd:cd15221   78 FFVHFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFC----IVFPFVFLLKR-----LPYCGHN 148
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 405966368 207 ----------------WSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMI 239
Cdd:cd15221  149 viphtycehmgiarlaCADITVNIWYGLTVALLTVGLDVVLIAVSYALI 197
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
51-163 5.62e-06

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 47.56  E-value: 5.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15938    2 LLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81
                         90       100       110
                 ....*....|....*....|....*....|...
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRR 163
Cdd:cd15938   82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSR 114
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
52-348 6.63e-06

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 47.25  E-value: 6.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQT 130
Cdd:cd15328    3 VLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSgRRWQLGRSLCQVWISFDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFK-STKRRAKiiilvIWIIAFLLALPEVI-VADLTRFVKRQYIDLLIFCgpQWS 208
Cdd:cd15328   83 LCCTASIWNVTAIALDRYWSITRHLEYTlRTRRRIS-----NVMIALTWALSAVIsLAPLLFGWGETYSEDSEEC--QVS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 209 DKTNQVVYQSviiVLMYLLPLVLMTVTYsmiavvlWtgKIPGAIEsanrpmmdgnvnraeeqlesRKKAAKMLITVVIG- 287
Cdd:cd15328  156 QEPSYTVFST---FGAFYLPLCVVLFVY-------W--KIYKAAQ--------------------KEKRAALMVGILIGv 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 288 FAVCYFPVHLFNILRyadalRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15328  204 FVLCWIPFFLTELIS-----PLCSCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
55-185 7.35e-06

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 47.13  E-value: 7.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaviiiCLPPTLLSDVTETWY---FGFAMCKIALFLQTT 131
Cdd:cd15171    6 LCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNL-----CFLLTLPFWAHAAWHggsLGNPTCKVLVALSSV 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 132 SVAVSVFTLSAISVERwYAICYPLRFKSTKRR----AKIIILVIWIIAFLLALPEVIV 185
Cdd:cd15171   81 GLHSEALFNVLLTVQA-SRVFFHGRLASSARRvapcGIIASVLAWLTAFLVTLPEFVF 137
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
54-157 7.53e-06

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 46.89  E-value: 7.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15237    5 ILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALG 84
                         90       100
                 ....*....|....*....|....
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRF 157
Cdd:cd15237   85 VTECVLLAVMAYDRYVAICNPLRY 108
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
54-340 1.08e-05

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 46.71  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLvcfAVWRNRSMRTVTN--IFIVNLAIADLaVIIICLPPTLLSDVT-ETWYFGFAMCKIALFLQT 130
Cdd:cd15969    5 VLYLIIFIGSILLNGL---AVWIFFHIRNKTSfiFYLKNIVIADL-LMTLTFPFKIIQDSGlGPWNFNFFLCRYTSVLFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPlrFKSTK----RRAKIIILVIWIIAFLLALPEVIVADltRFVKRQYIDLLIFCGPQ 206
Cdd:cd15969   81 ASMYTSIVFLGLISLDRYLKVVKP--FGDSRmysiTFTKVLSACVWLIMAFLSLPNIILTN--GQPTEDNIHDCSKLKSP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 WSDKTNQVVyqSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipGAIESANRPMMdgnvnraeEQLESRKKAAKMLITVVI 286
Cdd:cd15969  157 LGVKWHTAV--SYINICIFVAVLVILIVCYISIS---------RYIYKSSKQFI--------SSSSRTRKHNQSIRVVVA 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 287 GFAVCYFPVHLFNILRYADALRFVAPRMIQVL----SMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15969  218 VFFVCFLPYHLCRIPFTFSQLDKILDCTIKTIlyycKEATLFLSACNVCLDPIIYFFM 275
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
54-180 1.18e-05

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 46.39  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAM-------CKIAL 126
Cdd:cd15360    5 VLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIdwqtgagCAAAG 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPLRF--KSTKRRAKIIILVIWIIAFLLAL 180
Cdd:cd15360   85 FFTVFASELSVYTLTVITLERWHTITYAMQLdrKVRLRHAAVIMVGGWIFAFTVAL 140
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
54-162 1.29e-05

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 46.40  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAM-------CKIAL 126
Cdd:cd15359    5 VLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIdwqtgsgCSTAG 84
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPLRFKSTKR 162
Cdd:cd15359   85 FFTVFASELSVYTLTVITLERWHTITYAMQLDRKLR 120
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
55-153 1.44e-05

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 46.56  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLS--GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLS-DVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15218    4 LTSLGFIIGVSvvGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSvKNGSTWTYGTLTCKVIAFLGVL 83
                         90       100
                 ....*....|....*....|..
gi 405966368 132 SVAVSVFTLSAISVERWYAICY 153
Cdd:cd15218   84 SCFHTAFMLFCISVTRYLAIAH 105
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
52-345 1.47e-05

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 46.13  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSdvteTWYFG-----FAMCKIAL 126
Cdd:cd15917    3 LSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDL-VLSTSTVPKMLG----IFWFNareisFDACLAQM 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALP-EVIVADL----TRFVKRQYIDL 199
Cdd:cd15917   78 FFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTilTNTVVGKIGLAILLRAVALIIPlPLLVRRLpycgSNVISHSYCEH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 200 L----IFCGpqwsDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanrpmmdgnvnRAEEQLESRK 275
Cdd:cd15917  158 MavvkLACG----DTRVNSIYGLFVALLIVGFDLLFIALSYVLIL-------------------------RAVLQLPSKE 208
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 405966368 276 KAAKMLITV---VIGFAVCYFPVhLFNILRYadalRFV--APRMIQVLSMISHWLpyLNSSINPIIYnfmSVQTK 345
Cdd:cd15917  209 ARLKALSTCgshICVILIFYTPA-LFSFLTH----RFGhhVPPHVHILLANLYLL--LPPMLNPIVY---GVRTK 273
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
50-241 1.62e-05

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 46.06  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIvglsGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCK----IA 125
Cdd:cd15431    5 VLLLIVYLVTLL----GNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLaqmyIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 126 LFLQTTsvavSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIVADLTrfvkrqyidlliFC 203
Cdd:cd15431   81 LFLGIT----ECLLLAVMAYDRFVAICNPLRYTLimSWRVCIQLAAGSWVSAFLLTVIPVLTMPLH------------FC 144
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 405966368 204 GPQ----------------WSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAV 241
Cdd:cd15431  145 GPNvinhffcevqallklaCSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGV 198
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
57-180 1.78e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 46.08  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  57 ALTFIVGLSGNVLVCFAVWRNRS--MRTVTNIFIVNLAIADLAVIIICLPPTL-LSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd14981    8 ALMFVFGVLGNLLALIVLARSSKshKWSVFYRLVAGLAITDLLGILLTSPVVLaVYASNFEWDGGQPLCDYFGFMMSFFG 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLAL 180
Cdd:cd14981   88 LSSLLIVCAMAVERFLAITHPFFYNShvKKRRARLMLGAVWAFALLIAS 136
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
54-239 2.23e-05

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 45.43  E-value: 2.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFiVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTEtWYFGFAMCKIALFLQTTSV 133
Cdd:cd15072    6 ILLVEAL-VGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLRR-WPYGSEGCQAHGFQGFFTA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 134 AVSVFTLSAISVERWYAICYPlRFKSTKRRAKIIILVIWIIAFLLALPevivadLTRFVKRQYIDLLIFCGPQWS-DKTN 212
Cdd:cd15072   84 LASICSSAAIAWDRYHHYCTR-SKLQWSTAISLVLFVWLFSAFWAAMP------LLGWGEYDYEPLGTCCTLDYSkGDRN 156
                        170       180
                 ....*....|....*....|....*..
gi 405966368 213 QVVYQSVIIVLMYLLPLVLMTVTYSMI 239
Cdd:cd15072  157 YVSYLFTMAFFNFILPLFILLTSYSSI 183
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
52-239 2.38e-05

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 45.50  E-value: 2.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTfivgLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15424    7 ILIIYLLT----ILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKST--KRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLiFCGPQWSD 209
Cdd:cd15424   83 LGSTECLLLGAMAYDRYLAICHPLLYAAAmgRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHF-FCELPVVL 161
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 405966368 210 K--------TNQVVYQSVIIVLmyLLPLVLMTVTYSMI 239
Cdd:cd15424  162 KlacadthiTEAIVFGAGVLIL--LVPLSVILTSYGLI 197
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
51-163 2.63e-05

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 45.47  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  51 GIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT 130
Cdd:cd15429    2 GLFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISL 81
                         90       100       110
                 ....*....|....*....|....*....|...
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKSTKRR 163
Cdd:cd15429   82 ALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSG 114
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
52-156 2.64e-05

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 45.42  E-value: 2.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLlsdvTETWY----FGFAMCKIALF 127
Cdd:cd15951    3 ISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKML----SIFWFnsreIDFSACLTQMF 78
                         90       100
                 ....*....|....*....|....*....
gi 405966368 128 LQTTSVAVSVFTLSAISVERWYAICYPLR 156
Cdd:cd15951   79 FIHSFSTMESGIFVAMALDRYVAICNPLR 107
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
54-155 3.53e-05

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 45.09  E-value: 3.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15409    5 LVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSA 84
                         90       100
                 ....*....|....*....|..
gi 405966368 134 AVSVFTLSAISVERWYAICYPL 155
Cdd:cd15409   85 TTECFLLAAMAYDRYVAICNPL 106
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
53-298 3.72e-05

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 44.81  E-value: 3.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLaVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15166    4 LVFYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDL-IFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLA--LPEVI-------VADLTRFVKRQYIDLLifc 203
Cdd:cd15166   83 PSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLAstFPLLFlyedpdkASNFTTCLKMLDIIHL--- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 gpqwsdKTNQVVYQSVIIvLMYLLPLVLMTVTYSMIAVVLWTGKIpgaieSANRPmmdgnvnraeeqlESRKKAAKMLIT 283
Cdd:cd15166  160 ------KEVNVLNFTRLI-FFFLIPLFIMIGCYLVIIHNLVHGRT-----SKLKP-------------KVKEKSIRIIIT 214
                        250
                 ....*....|....*
gi 405966368 284 VVIGFAVCYFPVHLF 298
Cdd:cd15166  215 LIVQVLVCFVPFHIC 229
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
53-157 4.41e-05

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 44.85  E-value: 4.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15421    4 FSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTL 83
                         90       100
                 ....*....|....*....|....*
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRF 157
Cdd:cd15421   84 GGAECLLLALMAYDRYVAICHPLRY 108
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
52-341 4.76e-05

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 44.77  E-value: 4.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15364    3 LVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIFFC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRR--AKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLifcgpQWSD 209
Cdd:cd15364   83 NIYISILLLCCISIDRFVAVVYALESRGRRRQriAAFISFLIFIVVGLVHSPVFIMREGQTEGSHTCFETL-----QMDT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 210 KTNQVVYQSVIIvlMYLLPL-VLMTVTYSMIAVVlwtgkipgaiesanrpmmdgnvnRAEEQLESRKKA-AKML-ITVVI 286
Cdd:cd15364  158 QVAGFYYARFCI--GFAIPLaILIFTNYRIFRSI-----------------------QTSTSLTPHQKAkVKYLaIAVIV 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405966368 287 GFAVCYFPVHLFNILRyadALRFVAPR--------MIQVLSMISHWLPYLNSSINPIIYNFMS 341
Cdd:cd15364  213 IFLICFAPYHLVLLVR---AIAFSLYPngmcgfeeRIYTPSVIFLCLSTVNSVADPIIYVLVS 272
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
61-348 5.77e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 44.16  E-value: 5.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWY------FGFAMCKIALFLQTTSVA 134
Cdd:cd15354   12 IISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHlviedaFVRHIDNVFDSLICISVV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 135 VSVFTLSAISVERWYAICYPLRFKS--TKRRAKiiilviwiiafllalpeVIVADLTRFVKRQYIDLLIFcgpqwSDKTn 212
Cdd:cd15354   92 ASMCSLLAIAVDRYVTIFYALRYHNimTVRRAG-----------------IIIACIWTFCTGCGIIFILY-----SEST- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 213 qvvYQSVIIVLMYLLPLVLMTVTYSMIAVVLWT-----GKIPGAIESANRPMMDGNVNraeeqlesrkkaakmlITVVIG 287
Cdd:cd15354  149 ---YVIICLITMFFAMLFLMVSLYIHMFLLARThvkriAALPGYNSVRQRTSMKGAVT----------------LTILLG 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 405966368 288 -FAVCYFPVHLFNILRYAdalrfvAPRMIQVLSMISHWLPYL-----NSSINPIIYNFMSVQTKGAF 348
Cdd:cd15354  210 iFIVCWAPFFLHLILMIS------CPQNLYCVCFMSHFNMYLilimcNSVIDPLIYAFRSQEMRKTF 270
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
54-157 5.92e-05

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 44.35  E-value: 5.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15940    5 MLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFA 84
                         90       100
                 ....*....|....*....|....
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRF 157
Cdd:cd15940   85 CTEIFLLTIMAYDRYVAICNPLHY 108
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
54-156 6.47e-05

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 44.01  E-value: 6.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd13954    5 VLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLG 84
                         90       100
                 ....*....|....*....|...
gi 405966368 134 AVSVFTLSAISVERWYAICYPLR 156
Cdd:cd13954   85 GTECFLLAVMAYDRYVAICHPLH 107
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
61-164 6.83e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 44.02  E-value: 6.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAmckiALFLQT---------- 130
Cdd:cd15103   12 IVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPR----DSFEQHidnvidsmic 87
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 405966368 131 TSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRA 164
Cdd:cd15103   88 SSLLASICSLLAIAVDRYITIFYALRYHSimTVRRA 123
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
54-340 9.12e-05

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 43.62  E-value: 9.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSmrtvTNIFIV---NLAIADLAvIIICLPPTLLSDV-TETWYFGFAMCKIALFLQ 129
Cdd:cd15151    5 VLYTVLFLVGLILNSVAAWIFFHIPS----TSTFIVylkNTLVADLI-MTLMLPFKILSDSgLGPWQLRAFVCRFSAVVF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKSTK--RRAKIIILVIWIIAFLLALPEVIVAD--LTRFVKRQYIDLLIFCGP 205
Cdd:cd15151   80 YITMYISIILLGLISFDRYLKIVRPFGKSWVQrvRFAKILSGAVWLVMFLLSVPNMILSNkpATPISVKKCASLKSPLGL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 206 QWSDKTN---QVVYQSViivlmyllpLVLMTVTYSMIAVVLWtgkipgaiESANRpmmdgnvNRAEEQLESRKKAAKMLI 282
Cdd:cd15151  160 KWHEVVNyicQFIFWGV---------FALMVLFYTIISKKVY--------ESYKK-------SRSKDNKASKKTKAKVFI 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405966368 283 TVVIgFAVCYFPVHL----FNILRYADALRFVAPRMIQVLSMISHWLPYLNSSINPIIYNFM 340
Cdd:cd15151  216 IVAV-FFVCFAPFHFvrvpYTLSQTGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFL 276
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
52-300 9.36e-05

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 43.68  E-value: 9.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVL---VCFAVWRNRSMRtvtnIFIVNLAIADLaVIIICLPPTLLSDV-TETWYFGFAMCKIALF 127
Cdd:cd15149    3 IPVFYSLVFIVGILLNGVnfwIFFYVPSNKSFI----VYLKNIVFADL-LMSLTFPFKILSDVeLGPWQLNVIVCRYSAV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 128 LQTTSVAVSVFTLSAISVERWYAICYPL--RFKSTKRRAKIIILVIWIIAFLLALPEVIVAD--LTRFVKRQYIDLLIFC 203
Cdd:cd15149   78 IFYLNMYVGIIFFGLIGFDRYYKIVKPLhtSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNqsFHEANYTKCARLKSEL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 204 GPQWSDKTNqvvyqsVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanRPMMDGNVNRAEEQLESRKKAAKMLIT 283
Cdd:cd15149  158 GIQWHKASN------YICVSIFWVVFLLLIIFYVAIS----------------RKIYKSNQKFRRNSTNMKAKSSRNIFS 215
                        250
                 ....*....|....*..
gi 405966368 284 VVIGFAVCYFPVHLFNI 300
Cdd:cd15149  216 ILFVFFVCFVPYHALRI 232
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
55-160 1.78e-04

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 42.98  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  55 LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVA 134
Cdd:cd15235    7 LFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGN 86
                         90       100
                 ....*....|....*....|....*.
gi 405966368 135 VSVFTLSAISVERWYAICYPLRFKST 160
Cdd:cd15235   87 TDSFLLAVMAYDRYVAICHPLHYATV 112
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
52-337 2.33e-04

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 42.36  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGlsGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15914    5 ILLLLIYLFIIT--GNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIvadltrfvkrqYIDLLIFCGPQ--- 206
Cdd:cd15914   83 LGITECYLLTAMAYDRYLAICNPLHYPSimTPKLCTQLAAGCWLCGFLGPVPEII-----------LISTLPFCGPNqiq 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 207 -------------WSDKTNQVVYQSVIIVLMYLLPLVLMTVTYS-MIAVVLwtgKIPGAiesanrpmmdgnvnraeeqlE 272
Cdd:cd15914  152 hifcdfppllslaCTDTSLNVLVDFVIHAVIILLTFLLILLSYVkIISVVL---KIPSA--------------------E 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 405966368 273 SRKKA----AKMLITVVIgfavcYFPVHLFNILRYADALRFVAPRMIQVLSMIshwlpyLNSSINPIIY 337
Cdd:cd15914  209 GRQKAfstcAAHLTVVLL-----FFGSVSFMYLRLSKSYSLDYDRAIAVVYAV------LTPFFNPIIY 266
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
52-163 2.56e-04

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 42.25  E-value: 2.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15231    3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82
                         90       100       110
                 ....*....|....*....|....*....|..
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKSTKRR 163
Cdd:cd15231   83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSR 114
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
54-205 3.41e-04

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 41.92  E-value: 3.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTfivgLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15913    9 VIYILT----LLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLG 84
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIvadltrfvkrqYIDLLIFCGP 205
Cdd:cd15913   85 TTECFFLSVMAFDRYLAICRPLHYPTimTGQLCGKLVAFCWVCGFLWFLIPVV-----------LISQLPFCGP 147
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
54-155 3.46e-04

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 42.02  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15415    5 MLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFV 84
                         90       100
                 ....*....|....*....|..
gi 405966368 134 AVSVFTLSAISVERWYAICYPL 155
Cdd:cd15415   85 TTEGFLLAVMAYDRYVAICNPL 106
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
52-159 3.47e-04

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 41.77  E-value: 3.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15956    3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHA 82
                         90       100
                 ....*....|....*....|....*...
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS 159
Cdd:cd15956   83 FSAMESGVLVAMALDRFVAICNPLHYAT 110
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
52-160 3.93e-04

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 41.91  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIvglsGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15419    7 FLVIYMVTVL----GNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSL 82
                         90       100
                 ....*....|....*....|....*....
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKST 160
Cdd:cd15419   83 FGTTEGFLLAAMAYDRFIAICNPLLYPVI 111
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
44-155 4.50e-04

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 41.65  E-value: 4.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  44 FPDDWEWGIII--LYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAM 121
Cdd:cd15945    6 FTDYLSLKVTLflVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYG 85
                         90       100       110
                 ....*....|....*....|....*....|....
gi 405966368 122 CKIALFLQTTSVAVSVFTLSAISVERWYAICYPL 155
Cdd:cd15945   86 CALQMFFFAAFADAECLLLAVMAYDRYVAICNPL 119
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
61-348 5.28e-04

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 41.43  E-value: 5.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAV--------IIICLpptLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15353   12 IVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVsvsngsetVVITL---LNGNDTDAQSFTVNIDNVIDSVICSS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKiiilviwiiafllalpeVIVADLTRFVKRQYIDLLIFcgpqwSDK 210
Cdd:cd15353   89 LLASICSLLSIAVDRYFTIFYALQYHNimTVRRAG-----------------VIITCIWTACTVSGVLFIIY-----SDS 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 211 TnqvvyqSVIIVL--MYLLPLVLMTVTYSMIAVVLWTGKIPGAIESANRPMMDGnvnraeeqleSRKKAAkMLITVVIG- 287
Cdd:cd15353  147 S------VVIICLisMFFTMLALMASLYVHMFLLARLHIKRIAVLPGTGPIRQG----------ANMKGA-ITLTILLGv 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 288 FAVCYFPVHLFNILRYAdalrfvAPRMIQVLSMISHWLPYL-----NSSINPIIYNFMSVQTKGAF 348
Cdd:cd15353  210 FVVCWAPFFLHLIFYIS------CPRNPYCVCFMSHFNMYLilimcNSVIDPLIYAFRSQELRKTF 269
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
52-239 5.85e-04

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 41.21  E-value: 5.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLlsdvtETWYFG-----FAMCKIAL 126
Cdd:cd15952    3 IGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKML-----GIFWFNlreisFGGCLAQM 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 127 FLQTTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPEVIvadltrFVKRqyidlLIFCG 204
Cdd:cd15952   78 FFIHTFTGMESAVLVAMAFDRYVAICNPLRYTTilTNKVISVIALGIVLRPLLLVLPFVF------LILR-----LPFCG 146
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 PQWSDKT---------------NQVVYQSVIIVLMYLLPLVLMTVTYSMI 239
Cdd:cd15952  147 HNIIPHTycehmgiaklacasiRINIIYGLFAISVLVLDVILIALSYVLI 196
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
54-157 6.99e-04

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 40.93  E-value: 6.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15911    5 LLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLA 84
                         90       100
                 ....*....|....*....|....
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRF 157
Cdd:cd15911   85 ATECYLLAVMSYDRYLAICKPLHY 108
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
54-158 9.55e-04

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 40.77  E-value: 9.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15408   18 VVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFA 97
                         90       100
                 ....*....|....*....|....*
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFK 158
Cdd:cd15408   98 TTECYLLAAMAYDRYVAICNPLLYT 122
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
52-341 1.38e-03

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 40.16  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIiCLPPTLLSdvtetwYFGFAMCKIALFLQTT 131
Cdd:cd15163    3 LMVINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGL-SLPTRIVM------YYSAGNCLTCSFVHIF 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 132 SVAV----SVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYIDLLifcgpqw 207
Cdd:cd15163   76 SYFVnmycSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSILTTAIKFASCCLSKLF------- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 208 sdktnqvvyqsVIIVLMYLLPLVLMTVtysmiavvlWTGKIPGAIESANrpMMdgnvnraEEQLESRKKAAKMLITVVIG 287
Cdd:cd15163  149 -----------ALTVFEFFLPLLIITF---------FTIRIMCALSRPG--LM-------HQSRERRMRAVQLLITVLII 199
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405966368 288 FAVCYFPVHLFNILRYadalrfVAPRMIQVLSMISHW----LPYLNSSINPIIYNFMS 341
Cdd:cd15163  200 FMICFTPFHVRQVAVA------FNPDIPHHTSLIVYHvtvtLSSLNSCMDPIVYCFVT 251
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
54-157 1.87e-03

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 39.62  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15936    5 LVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTG 84
                         90       100
                 ....*....|....*....|....
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRF 157
Cdd:cd15936   85 GAEVFLLSVMAYDRYIAIHKPLHY 108
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
52-157 1.90e-03

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 39.72  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15942    3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82
                         90       100
                 ....*....|....*....|....*.
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRF 157
Cdd:cd15942   83 LGCAECFLYTVMAYDRFLAICKPLHY 108
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
52-345 2.42e-03

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 39.17  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTL------LSDVTetwyfgFAMCKIA 125
Cdd:cd15953    3 ISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALcifwfnLKEIT------FSGCLTQ 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 126 LFLQTTSVAVSVFTLSAISVERWYAICYPLRFKS--TKRRAKIIILVIWIIAFLLALPE-VIVADL----TRFVKRQYID 198
Cdd:cd15953   77 MFFIHTLSIMESAVLVAMAFDRYVAICNPLRYATilTNSRIAKLGLVGLIRGVLLILPLpLLLSRLpfcaNRIIPHTYCE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 199 LL----IFCGpqwsDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAvvlwtgkipgaiesanrpmmdgnvnRAEEQLESR 274
Cdd:cd15953  157 HMavvkLACG----DTTINRIYGLVVALLVVGLDLLLIALSYALII-------------------------RAVLRLSSK 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 275 KKAAKMLITVV--IGFAVCYFPVHLFNILRYadalRF---VAPRMIQVLSMISHWLPylnSSINPIIYnfmSVQTK 345
Cdd:cd15953  208 KARQKALNTCTahICVILMSYTPALFSFLTH----RFgqgIAPHIHIILANLYLLVP---PMLNPIIY---GVKTK 273
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
122-337 3.32e-03

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 39.08  E-value: 3.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 122 CKIALFLQTTSVAVSVFTLSAISVERWYAICYPLR-FKSTKRRAKIIILVIWIIAFLLALpeviVADLTRFVKRQYIDLL 200
Cdd:cd15965   80 CQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRcLTPGKCRTITILILIWIIGFIIAF----IPLSNKEFFRNYYGTN 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 201 IFCGPQWSDKTNQV---VYQSVIIVLMYLLPLVLMTVTY-SMIAVVLWTGKIPGAIESanrpmmdgnvnraeeQLESRKK 276
Cdd:cd15965  156 GVCFPLHSEQPESTgaqIYSVVIFLGLNLAAFIIIVFSYgSMFYSIHQTAIMATEISN---------------HIKKEMT 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 405966368 277 AAKMLITVVIGFAVCYFPVHLfnilryadaLRFVAPRMIQVLSMISHW-----LPyLNSSINPIIY 337
Cdd:cd15965  221 LAKRFFFIVFTDALCWIPIFI---------LKLLSLLQVEIPGTISSWvvifiLP-INSALNPILY 276
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
50-160 3.65e-03

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 38.94  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15405    1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80
                         90       100       110
                 ....*....|....*....|....*....|.
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFKST 160
Cdd:cd15405   81 CFFVISECYVLTAMAYDRYVAICNPLLYTVT 111
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
52-160 3.89e-03

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 38.61  E-value: 3.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15428    3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82
                         90       100
                 ....*....|....*....|....*....
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKST 160
Cdd:cd15428   83 FGITECALLSVMSYDRYVAICLPLRYSLI 111
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
54-163 4.12e-03

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 38.59  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTV-TNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTS 132
Cdd:cd15935    5 VLVLACYAAILLGNLLIVVTVHADPHLLQSpMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFL 84
                         90       100       110
                 ....*....|....*....|....*....|.
gi 405966368 133 VAVSVFTLSAISVERWYAICYPLRFKSTKRR 163
Cdd:cd15935   85 GGSEMLLLTLMAYDRYVAICHPLRYLAVMNR 115
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
58-156 4.73e-03

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 38.59  E-value: 4.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  58 LTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSVAVSV 137
Cdd:cd15225    9 LIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTEC 88
                         90
                 ....*....|....*....
gi 405966368 138 FTLSAISVERWYAICYPLR 156
Cdd:cd15225   89 FLLAAMAYDRYVAICNPLR 107
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
53-158 4.84e-03

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 38.23  E-value: 4.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  53 IILYALTFIVGLS---GNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQ 129
Cdd:cd15946    1 SILFAVFLLIYLSillGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIF 80
                         90       100
                 ....*....|....*....|....*....
gi 405966368 130 TTSVAVSVFTLSAISVERWYAICYPLRFK 158
Cdd:cd15946   81 LALGITECTLFSVMAYDRYVAICHPLRYK 109
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
61-164 5.06e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 38.24  E-value: 5.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  61 IVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETwyfGFAMCKIALFLQT---------T 131
Cdd:cd15351   12 LVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEH---GVLVCRAPMLQHMdnvidtmicS 88
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS--TKRRA 164
Cdd:cd15351   89 SVVSSLSFLGAIAVDRYITIFYALRYHSimTLQRA 123
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
54-157 5.60e-03

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 37.98  E-value: 5.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15918    5 GLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFG 84
                         90       100
                 ....*....|....*....|....
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRF 157
Cdd:cd15918   85 DLDNFLLAVMAYDRYVAICHPLHY 108
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
50-348 5.88e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 38.08  E-value: 5.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  50 WGIIILYALTFIVglSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLA-----VIIICLPPTLLSDVTETWYFGfamcki 124
Cdd:cd15961    3 WDIVLCTSGTLIS--CENAIVVLIIFQNPSLRAPMFLLIGSLALADLLagiglILNFIFAYLLQSEAAKLVTVG------ 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 125 alfLQTTSVAVSVFTLSAISVERWYAICYPLRFKSTKRRAKIIILVIWIIAFLLALPEVIVADLTRFVKRQYidllifCG 204
Cdd:cd15961   75 ---LIVASFSASVCSLLAITVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLADEST------CS 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 205 PQWSDKTNQVVYQSVIIVLMYLLPLVLmtvtYSMIAVVLwtgkipgaIESANRPMMDGNVNRAEEQLESRKKAAKMLItV 284
Cdd:cd15961  146 VVRPLTKNNAAILSVSFLLMFALMLQL----YIQICKIV--------MRHAHQIALQHHFLATSHYVTTRKGVSTLAI-I 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 405966368 285 VIGFAVCYFPVHLFNILryADalrFVAPRMIQVLSMIShwlPYLNSSINPIIYNFMSVQTKGAF 348
Cdd:cd15961  213 LGTFAACWMPFTLYSLI--AD---YTYPSIYTYATLLP---ATYNSIINPVIYAFRNQEIQKAL 268
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
52-158 6.07e-03

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 38.22  E-value: 6.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15949   19 ISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHS 98
                         90       100
                 ....*....|....*....|....*..
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFK 158
Cdd:cd15949   99 FSAIESGIFLAMAFDRYVAICNPLRHK 125
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
52-159 6.41e-03

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 37.96  E-value: 6.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  52 IIILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTT 131
Cdd:cd15948    4 ISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHS 83
                         90       100
                 ....*....|....*....|....*...
gi 405966368 132 SVAVSVFTLSAISVERWYAICYPLRFKS 159
Cdd:cd15948   84 FSIMESAVLLAMAFDRYVAICNPLRYAT 111
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
54-337 6.80e-03

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 38.24  E-value: 6.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQT--- 130
Cdd:cd14996    5 IIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANFFGTlvi 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 131 -TSVAVSVFTLSAISVERwYAI------------CY----PLRFKSTKRRAKIIILVIWIIAFLLALPEV-IVADLTRFV 192
Cdd:cd14996   85 hVSMCVSILILSWIAISR-YATlmkhdsatqkqsCYekifYGHFLKRFRQPKFARYLCIYIWGVVLCIIIpVVVYYSVRE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368 193 KRQYIDLLIFCGPQWSDKTNQVVYQSVIIVLMYLLPLVLMTVTYSMIAVvLWTGKIPGAIEsanrpmmdgnvnraEEQLE 272
Cdd:cd14996  164 ADEDGESLCYNRQVELGAKGSQIAGLIATTFFFLFFLVVLLSYYSFVNH-LRRIQKNTCIS--------------EKDLI 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405966368 273 SRKKAAKMLITVVIgFAVCYFPVHLFNILRYAdalrFVAPRMIQVLSM------ISHWLPYLNSSINPIIY 337
Cdd:cd14996  229 YRSVKRNILIIQAL-LVVCFLPYHIFKPVFYV----LHQREDCQQLNYlietknILTCLASARSSTDPIMY 294
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
54-157 6.97e-03

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 38.06  E-value: 6.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIAL----FLQ 129
Cdd:cd15915    5 VLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLhffhFLG 84
                         90       100
                 ....*....|....*....|....*...
gi 405966368 130 TTSVAVsvftLSAISVERWYAICYPLRF 157
Cdd:cd15915   85 SSEAML----LAVMAYDRYVAICNPLRY 108
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
54-159 7.47e-03

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 37.76  E-value: 7.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  54 ILYALTFIVGLSGNVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTETWYFGFAMCKIALFLQTTSV 133
Cdd:cd15412    5 VLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALV 84
                         90       100
                 ....*....|....*....|....*.
gi 405966368 134 AVSVFTLSAISVERWYAICYPLRFKS 159
Cdd:cd15412   85 ITEYYMLAVMAYDRYMAICNPLLYSV 110
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
67-162 8.19e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 37.83  E-value: 8.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405966368  67 NVLVCFAVWRNRSMRTVTNIFIVNLAIADLAVIIICLPPTLLSDVTeTWYFGFAMCKIALFLQTTSVAVSVFTLSAISVE 146
Cdd:cd15102   18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGAR-TLRLSPAQWFLREGSMFVALSASVFSLLAIAIE 96
                         90
                 ....*....|....*.
gi 405966368 147 RWYAICYPLRFKSTKR 162
Cdd:cd15102   97 RHLTMAKMKPYGASKT 112
 
Blast search parameters
Data Source: Live blast search RID = KPRTFZNC013
User Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01   Maximum number of hits: 500

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure