amylo-alpha-1,6-glucosidase catalyzes the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin and with 4-alpha-D-glucanotransferase, constitute a glycogen debranching enzyme
N-terminal domain of (some) glycogen debranching enzymes; This domain is found on the ...
32-229
8.52e-56
N-terminal domain of (some) glycogen debranching enzymes; This domain is found on the N-terminal of some glycogen debranching enzymes and is usually followed by the GDE_C (PF06202) and in this sense it is analogous (but probably not homologous) to the GDE_N (PF12439). Its exact function is unknown
:
Pssm-ID: 434175 Cd Length: 193 Bit Score: 188.95 E-value: 8.52e-56
N-terminal domain of (some) glycogen debranching enzymes; This domain is found on the ...
32-229
8.52e-56
N-terminal domain of (some) glycogen debranching enzymes; This domain is found on the N-terminal of some glycogen debranching enzymes and is usually followed by the GDE_C (PF06202) and in this sense it is analogous (but probably not homologous) to the GDE_N (PF12439). Its exact function is unknown
Pssm-ID: 434175 Cd Length: 193 Bit Score: 188.95 E-value: 8.52e-56
Amylo-alpha-1,6-glucosidase; This family includes human glycogen branching enzyme Swiss:P35573. ...
369-653
7.64e-20
Amylo-alpha-1,6-glucosidase; This family includes human glycogen branching enzyme Swiss:P35573. This enzyme contains a number of distinct catalytic activities. It has been shown for the yeast homolog Swiss:O93808 that mutations in this region disrupt the enzymes Amylo-alpha-1,6-glucosidase (EC:3.2.1.33).
Pssm-ID: 428822 Cd Length: 370 Bit Score: 92.01 E-value: 7.64e-20
N-terminal domain of (some) glycogen debranching enzymes; This domain is found on the ...
32-229
8.52e-56
N-terminal domain of (some) glycogen debranching enzymes; This domain is found on the N-terminal of some glycogen debranching enzymes and is usually followed by the GDE_C (PF06202) and in this sense it is analogous (but probably not homologous) to the GDE_N (PF12439). Its exact function is unknown
Pssm-ID: 434175 Cd Length: 193 Bit Score: 188.95 E-value: 8.52e-56
Amylo-alpha-1,6-glucosidase; This family includes human glycogen branching enzyme Swiss:P35573. ...
369-653
7.64e-20
Amylo-alpha-1,6-glucosidase; This family includes human glycogen branching enzyme Swiss:P35573. This enzyme contains a number of distinct catalytic activities. It has been shown for the yeast homolog Swiss:O93808 that mutations in this region disrupt the enzymes Amylo-alpha-1,6-glucosidase (EC:3.2.1.33).
Pssm-ID: 428822 Cd Length: 370 Bit Score: 92.01 E-value: 7.64e-20
Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain; This family consists of bacterial ...
365-555
3.04e-14
Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain; This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.
Pssm-ID: 407469 Cd Length: 340 Bit Score: 74.66 E-value: 3.04e-14
Glycosyl-hydrolase family 116, catalytic region; This represents a family of archaeal, ...
374-612
2.53e-06
Glycosyl-hydrolase family 116, catalytic region; This represents a family of archaeal, bacterial and eukaryotic glycosyl hydrolases, that belong to superfamily GH116. The primary catabolic pathway for glucosylceramide is catalysis by the lysosomal enzyme glucocerebrosidase. In higher eukaryotes, glucosylceramide is the precursor of glycosphingolipids, a complex group of ubiquitous membrane lipids. Mutations in the human protein cause motor-neurone defects in hereditary spastic paraplegia. The catalytic nucleophile, identified in UniProtKB:Q97YG8_SULSO, is a glutamine-335, with the likely acid/base at Asp-442 and the aspartates at Asp-406 and Asp-458 residues also playing a role in the catalysis of glucosides and xylosides that are beta-bound to hydrophobic groups. The family is defined as GH116, which presently includes enzymes with beta-glucosidase, EC:3.2.1.21, beta-xylosidase, EC:3.2.1.37, and glucocerebrosidase EC:3.2.1.45 activity.
Pssm-ID: 461391 Cd Length: 362 Bit Score: 50.33 E-value: 2.53e-06
Trehalase; Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a ...
473-605
6.49e-03
Trehalase; Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a physiological hallmark of heat-shock response in yeast and protects of proteins and membranes against a variety of stresses. This family is found in conjunction with pfam07492 in fungi.
Pssm-ID: 395961 [Multi-domain] Cd Length: 509 Bit Score: 39.62 E-value: 6.49e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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