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Conserved domains on  [gi|511487106|gb|EPD12106|]
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Drug resistance transporter EmrB/QacA subfamily protein, partial [Lacticaseibacillus paracasei subsp. paracasei Lpp48]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 13-129 2.66e-27

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17321:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 370  Bit Score: 103.41  E-value: 2.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 511487106  93 ATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGER 117
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 13-129 2.66e-27

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 103.41  E-value: 2.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 511487106  93 ATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGER 117
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 8-129 1.85e-20

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 85.51  E-value: 1.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106    8 LCFIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFS 87
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 511487106   88 AACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEK 123
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 10-129 2.27e-20

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 83.71  E-value: 2.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAA 89
Cdd:COG0477   16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 511487106  90 CMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:COG0477   96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARE 135
PRK10504 PRK10504
putative transporter; Provisional
 18-116 1.11e-11

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 60.52  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  18 FMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLS 97
Cdd:PRK10504  20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99

                         90
                 ....*....|....*....
gi 511487106  98 MLITFRFFQGLGGAIITPI 116
Cdd:PRK10504 100 ELLLARVLQGVGGAMMVPV 118
MFS_1 pfam07690
Major Facilitator Superfamily;
13-129 1.06e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.73  E-value: 1.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   13 LTIAMFMGTLDTTIVNIAIPK-IMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACM 91
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 511487106   92 TATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE 118
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 13-129 2.66e-27

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 103.41  E-value: 2.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 511487106  93 ATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGER 117
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 13-129 5.97e-23

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 91.87  E-value: 5.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 511487106  93 ATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEK 117
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 8-129 1.85e-20

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 85.51  E-value: 1.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106    8 LCFIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFS 87
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 511487106   88 AACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEK 123
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 10-129 2.27e-20

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 83.71  E-value: 2.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAA 89
Cdd:COG0477   16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 511487106  90 CMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:COG0477   96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARE 135
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 13-118 8.48e-19

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 79.91  E-value: 8.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLnGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEF-GGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79

                         90       100
                 ....*....|....*....|....*.
gi 511487106  93 ATSLSMLITFRFFQGLGGAIITPIVL 118
Cdd:cd17502   80 APNMTMLIVGRAIQGIGGGGLMSLAF 105
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-129 1.20e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 79.63  E-value: 1.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   2 TRFTKALCFIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLL 81
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 511487106  82 LFGGFSAACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:COG2814   84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER 131
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 10-120 8.40e-16

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 71.83  E-value: 8.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAA 89
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 511487106  90 CMTATSLSMLITFRFFQGLGGAIITPIVLPM 120
Cdd:cd17474   81 CGLSDSFALLLAGRALQGIGAAGLGPLALTL 111
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
10-129 1.80e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 62.58  E-value: 1.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAA 89
Cdd:COG2271   12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 511487106  90 CMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:COG2271   92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKE 131
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 17-111 2.71e-12

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 62.21  E-value: 2.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  17 MFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSL 96
Cdd:cd17320    8 VALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSI 87

                         90
                 ....*....|....*
gi 511487106  97 SMLITFRFFQGLGGA 111
Cdd:cd17320   88 EQLLIARFLQGLGAA 102
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 13-130 5.04e-12

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 61.44  E-value: 5.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 511487106  93 ATSLSMLITFRFFQGLGGAIItPIVLPMGIEVFGKEKI 130
Cdd:cd17504   81 APNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERV 117
PRK10504 PRK10504
putative transporter; Provisional
 18-116 1.11e-11

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 60.52  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  18 FMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLS 97
Cdd:PRK10504  20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99

                         90
                 ....*....|....*....
gi 511487106  98 MLITFRFFQGLGGAIITPI 116
Cdd:PRK10504 100 ELLLARVLQGVGGAMMVPV 118
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 13-129 1.73e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.90  E-value: 1.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 511487106  93 ATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE 117
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 13-115 1.41e-10

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 57.27  E-value: 1.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17476    3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82

                         90       100
                 ....*....|....*....|...
gi 511487106  93 ATSLSMLITFRFFQGLGGAIITP 115
Cdd:cd17476   83 SPNFIFFIICRALQGLGPAFLLP 105
MFS_1 pfam07690
Major Facilitator Superfamily;
13-129 1.06e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.73  E-value: 1.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   13 LTIAMFMGTLDTTIVNIAIPK-IMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACM 91
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 511487106   92 TATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE 118
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 13-129 3.32e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 53.32  E-value: 3.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17324    4 LALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 511487106  93 ATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:cd17324   84 APSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
10-129 3.45e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 53.35  E-value: 3.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAA 89
Cdd:COG2223    7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 511487106  90 CMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:COG2223   87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR 126
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 1-117 6.48e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 52.36  E-value: 6.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106    1 MTRFTKALcFIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGL 80
Cdd:TIGR00895  11 LSRYQWRA-IILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSI 89

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 511487106   81 LLFGGFSAACMTATSLSMLITFRFFQGLGGAIITPIV 117
Cdd:TIGR00895  90 LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNL 126
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 7-109 3.98e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 50.28  E-value: 3.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   7 ALCFIgltIAMFMGtLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGF 86
Cdd:cd17365    2 ALCFL---IIVLDG-FDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLF 77

                         90       100
                 ....*....|....*....|...
gi 511487106  87 SAACMTATSLSMLITFRFFQGLG 109
Cdd:cd17365   78 TLLTAFAQSVLQLALLRFLTGLG 100
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 13-128 4.51e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.12  E-value: 4.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 511487106  93 ATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKE 128
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPER 116
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 13-111 9.65e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 49.11  E-value: 9.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17319    8 LFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF 87

                         90
                 ....*....|....*....
gi 511487106  93 ATSLSMLITFRFFQGLGGA 111
Cdd:cd17319   88 ATSLTSLYVLRFLLGVAEA 106
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-129 2.42e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.93  E-value: 2.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   1 MTRFTKALCFIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGL 80
Cdd:COG0738    1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 511487106  81 LLFGGFSAACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:COG0738   81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA 129
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
29-109 6.22e-07

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 46.94  E-value: 6.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  29 IAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLSMLITFRFFQGL 108
Cdd:PRK10473  24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103


                 .
gi 511487106 109 G 109
Cdd:PRK10473 104 G 104
PRK14995 PRK14995
SmvA family efflux MFS transporter;
21-118 7.05e-07

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 46.64  E-value: 7.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  21 TLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLSMLI 100
Cdd:PRK14995  19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI 98

                         90
                 ....*....|....*...
gi 511487106 101 TFRFFQGLGGAIITPIVL 118
Cdd:PRK14995  99 ATRALLAIGAAMIVPATL 116
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 10-115 7.36e-07

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 46.67  E-value: 7.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAA 89
Cdd:pfam05977  12 FRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTL 91

                          90       100       110
                  ....*....|....*....|....*....|.
gi 511487106   90 CMTAT-----SLSMLITFRFFQGLGGAIITP 115
Cdd:pfam05977  92 LTLLAglgllSPWLLLGLTFLGGIGTALMDP 122
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 11-112 2.44e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 45.31  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  11 IGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSlANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAAC 90
Cdd:cd06179    1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                         90       100
                 ....*....|....*....|..
gi 511487106  91 MTATSLSMLITFRFFQGLGGAI 112
Cdd:cd06179   80 GTAKSVNMLIGGQALIGIGAGT 101
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 5-109 3.60e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 44.57  E-value: 3.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   5 TKALCFIgltIAMFMGtLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFG 84
Cdd:PRK11551  16 TIGLCFL---VALLEG-LDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFG 91

                         90       100
                 ....*....|....*....|....*
gi 511487106  85 GFSAACMTATSLSMLITFRFFQGLG 109
Cdd:PRK11551  92 LFSLATAQAWDFPSLLVARLLTGVG 116
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 10-109 3.69e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.60  E-value: 3.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAA 89
Cdd:cd17371    1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80

                         90       100
                 ....*....|....*....|
gi 511487106  90 CMTATSLSMLITFRFFQGLG 109
Cdd:cd17371   81 CGFAQNYWQLLILRALAGLG 100
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
30-111 5.48e-06

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 44.14  E-value: 5.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  30 AIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLSMLITFRFFQGLG 109
Cdd:PRK11102  13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92


                 ..
gi 511487106 110 GA 111
Cdd:PRK11102  93 AA 94
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 10-129 7.16e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 43.74  E-value: 7.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLAN--TSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFS 87
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLlqTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 511487106  88 AACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKR 122
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 11-118 7.55e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 43.72  E-value: 7.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  11 IGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANT-SWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAA 89
Cdd:cd17473    2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81

                         90       100
                 ....*....|....*....|....*....
gi 511487106  90 CMTATSLSMLITFRFFQGLGGAIITPIVL 118
Cdd:cd17473   82 GLFLDSLYALLASRALLGIGVAGIMTLAT 110
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 13-111 8.47e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 43.33  E-value: 8.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17323    4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL 83

                         90
                 ....*....|....*....
gi 511487106  93 ATSLSMLITFRFFQGLGGA 111
Cdd:cd17323   84 APNIAMLIILRFLQGFFGS 102
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
10-120 1.04e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 43.32  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIA--IPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFS 87
Cdd:COG2807   18 LLLLAIVLVALNLRPAITSVGplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97

                         90       100       110
                 ....*....|....*....|....*....|...
gi 511487106  88 AACMTATSLSMLITFRFFQGLGGAIITPIVLPM 120
Cdd:COG2807   98 LLRSLAPSVALLLAGTALIGAGIAVGNVLLPGL 130
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 13-130 1.26e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.97  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  13 LTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMT 92
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 511487106  93 ATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEKI 130
Cdd:cd17489   81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRR 118
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 8-109 2.18e-05

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 42.17  E-value: 2.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   8 LCFIGlTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFS 87
Cdd:cd17359    2 ISLVA-ALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80

                         90       100
                 ....*....|....*....|..
gi 511487106  88 AACMTATSLSMLITFRFFQGLG 109
Cdd:cd17359   81 LGSAFSPNFTIFIIARIIGGLA 102
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 30-122 2.77e-05

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 42.18  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  30 AIPKIMTD----LNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLSMLITFRFF 105
Cdd:cd17358   24 ALPSLMSDnslsLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFL 103

                         90
                 ....*....|....*..
gi 511487106 106 QGLGGAIITpIVLPMGI 122
Cdd:cd17358  104 AGFGGGAAS-VVVPVYI 119
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 3-129 3.43e-05

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 41.89  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106    3 RFTKALCFIgLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLglll 82
Cdd:TIGR01299 163 RFQWALFFV-LGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLI---- 237

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   83 fggfsaaCMTATSL-----SMLITFRFFQ--------GLGGAIitPIVLPMGIEVFGKEK 129
Cdd:TIGR01299 238 -------CLSVNGFfaffsSFVQGYGFFLfcrllsgfGIGGAI--PIVFSYFAEFLAQEK 288
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 5-131 3.82e-05

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 41.60  E-value: 3.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106    5 TKALCFIGLTIAMfMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFG 84
Cdd:TIGR00710   3 AKAFALLLGCLSI-LGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 511487106   85 GFSAACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEKIN 131
Cdd:TIGR00710  82 LSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELS 128
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
10-128 4.09e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.50  E-value: 4.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNG-SLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSA 88
Cdd:COG2814  209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 511487106  89 ACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKE 128
Cdd:COG2814  289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPE 328
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 3-129 4.39e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.41  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   3 RFTKALCFIGLTIAMFMGTLDTTIvniaiPKIMTDLNG-SLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLL 81
Cdd:cd17325  199 RRLLALFLAIFVLAFAFGALEPFL-----PLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 511487106  82 LFGGFSAACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:cd17325  274 LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
10-120 6.53e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.04  E-value: 6.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTD-LNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSA 88
Cdd:COG2211  230 FLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309

                         90       100       110
                 ....*....|....*....|....*....|....
gi 511487106  89 AC--MTATSLSMLITFRFFQGLGGAIITPIVLPM 120
Cdd:COG2211  310 LLffLGPGNLWLLLVLAALAGIGLGAILVLPWAM 343
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 54-128 7.76e-05

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 40.77  E-value: 7.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   54 LAMSVFMI-------TASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFG 126
Cdd:TIGR00898 131 LTQSCFFVgvllgsfVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLP 210


                  ..
gi 511487106  127 KE 128
Cdd:TIGR00898 211 KK 212
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 10-115 2.35e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAA 89
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 511487106  90 CMTAT-----SLSMLITFRFFQGLGGAIITP 115
Cdd:cd06173   81 LALLAllgslSLWLLLVLAFLLGIASAFFGP 111
2_A_01_02 TIGR00880
Multidrug resistance protein;
46-129 4.75e-04

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 37.63  E-value: 4.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   46 SWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVF 125
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80


                  ....
gi 511487106  126 GKEK 129
Cdd:TIGR00880  81 PPEE 84
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 23-117 4.78e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 38.32  E-value: 4.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  23 DTTIVNIAIPKIMTDLNGSLANT--SWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLSMLI 100
Cdd:cd17315   12 DLGVINGALLYIAKDLGFGLSTSlqGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLI 91

                         90
                 ....*....|....*..
gi 511487106 101 TFRFFQGLGGAIITPIV 117
Cdd:cd17315   92 VGRFLLGLGVGLASVLV 108
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 51-116 6.52e-04

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 37.97  E-value: 6.52e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 511487106  51 IYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLSMLITFRFFQGLgGAIITPI 116
Cdd:cd17472   40 IYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS-GAISSVV 104
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 46-129 8.18e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 37.56  E-value: 8.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  46 SWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVF 125
Cdd:cd17317   28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107


                 ....
gi 511487106 126 GKEK 129
Cdd:cd17317  108 GPKY 111
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 8-116 1.11e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 37.60  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106   8 LCFIGLtiamfMGTLDTTIVNIAIPKIMTDLNgslANTSWVMTIYTLAMSVFMITA---SKIADRFGRKKIMLLGLLLFG 84
Cdd:cd17328    4 LFLINL-----LNYMDRFTIAGVLPDIQSDFL---IDDSLAGLLQTVFIISYMVLSpifGYLGDRYNRKWILAVGILIWS 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 511487106  85 GFSAACMTATSLSMLITFRFFQGLGGAIITPI 116
Cdd:cd17328   76 AATLLSSFAPNFWQLLLFRALVGIGEASYSPI 107
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
10-127 3.49e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 35.99  E-value: 3.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNG-SLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSA 88
Cdd:COG0738  212 LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGlSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL 291

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 511487106  89 ACMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGK 127
Cdd:COG0738  292 LALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGK 330
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 10-129 4.02e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 36.05  E-value: 4.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAA 89
Cdd:cd17438    1 FFVLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 511487106  90 CMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:cd17438   81 SSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREK 120
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 31-115 4.55e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 35.68  E-value: 4.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  31 IPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLSMLITFRFFQGLGG 110
Cdd:cd17475   19 APFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGY 98


                 ....*
gi 511487106 111 AIITP 115
Cdd:cd17475   99 GSVQP 103
emrD PRK11652
multidrug transporter EmrD;
25-109 4.94e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 35.65  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  25 TIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAACMTATSLSMLITFRF 104
Cdd:PRK11652  25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104


                 ....*
gi 511487106 105 FQGLG 109
Cdd:PRK11652 105 IQGLG 109
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 10-129 8.40e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 34.77  E-value: 8.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511487106  10 FIGLTIAMFMGTLDTTIVNIAIPKIMTDLNGSLANTSWVMTIYTLAMSVFMITASKIADRFGRKKIMLLGLLLFGGFSAA 89
Cdd:cd17363    1 FFVLGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 511487106  90 CMTATSLSMLITFRFFQGLGGAIITPIVLPMGIEVFGKEK 129
Cdd:cd17363   81 SSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREK 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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