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Conserved domains on  [gi|555697434|gb|ESO00667|]
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hypothetical protein HELRODRAFT_175648 [Helobdella robusta]

Protein Classification

GDNF family receptor( domain architecture ID 10492250)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF; similar to Homo sapiens GDNF family receptor alpha-like

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 167-251 1.96e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 46.37  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555697434  167 CLWRRRWCSRESRCLESLATFRAECRENKNTKRCLPnNWSACHLSLIS-----LRKHSRDLLSCQCGHFKNQQlnKKCHK 241
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP-NPARCLRAYRMtpnyvDNLGTSLLLWCTCKGSGNQD--EECEE 77

                          90
                  ....*....|
gi 555697434  242 FQQNLLSNAC 251
Cdd:pfam02351  78 FRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 390-454 8.48e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 36.08  E-value: 8.48e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555697434   390 CTHLVDRCIDDDVCRQSWYDFNHHCPVETPKYYKTSSFARCQENQKCTA-SIVYLMGTLLSTNCTC 454
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAYCGLAlRPFYDDNSSVLLFCTC 66
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 301-347 9.08e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 36.08  E-value: 9.08e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 555697434   301 CLYVYRRCNLDQQCSSYLESMMHACY-------WESNGDHCNRKSCLTQIRNFF 347
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSpspssscPGENSEACLRAYCGLALRPFY 54
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 167-251 1.96e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 46.37  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555697434  167 CLWRRRWCSRESRCLESLATFRAECRENKNTKRCLPnNWSACHLSLIS-----LRKHSRDLLSCQCGHFKNQQlnKKCHK 241
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP-NPARCLRAYRMtpnyvDNLGTSLLLWCTCKGSGNQD--EECEE 77

                          90
                  ....*....|
gi 555697434  242 FQQNLLSNAC 251
Cdd:pfam02351  78 FRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 390-454 8.48e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 36.08  E-value: 8.48e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555697434   390 CTHLVDRCIDDDVCRQSWYDFNHHCPVETPKYYKTSSFARCQENQKCTA-SIVYLMGTLLSTNCTC 454
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAYCGLAlRPFYDDNSSVLLFCTC 66
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 301-347 9.08e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 36.08  E-value: 9.08e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 555697434   301 CLYVYRRCNLDQQCSSYLESMMHACY-------WESNGDHCNRKSCLTQIRNFF 347
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSpspssscPGENSEACLRAYCGLALRPFY 54
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 167-251 1.96e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 46.37  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555697434  167 CLWRRRWCSRESRCLESLATFRAECRENKNTKRCLPnNWSACHLSLIS-----LRKHSRDLLSCQCGHFKNQQlnKKCHK 241
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP-NPARCLRAYRMtpnyvDNLGTSLLLWCTCKGSGNQD--EECEE 77

                          90
                  ....*....|
gi 555697434  242 FQQNLLSNAC 251
Cdd:pfam02351  78 FRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 390-454 8.48e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 36.08  E-value: 8.48e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555697434   390 CTHLVDRCIDDDVCRQSWYDFNHHCPVETPKYYKTSSFARCQENQKCTA-SIVYLMGTLLSTNCTC 454
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAYCGLAlRPFYDDNSSVLLFCTC 66
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 301-347 9.08e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 36.08  E-value: 9.08e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 555697434   301 CLYVYRRCNLDQQCSSYLESMMHACY-------WESNGDHCNRKSCLTQIRNFF 347
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSpspssscPGENSEACLRAYCGLALRPFY 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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