|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
24-426 |
2.14e-99 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 301.03 E-value: 2.14e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 24 TWRLLPFLFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWAL 103
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 104 ISTGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMqafngvqGL 183
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL-------LL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 184 ANWQWLFLLEAIPSLILGVVTLMYLPngiraakwltdtekqlledriaqdgagklnakisrvlgngRVWFMAAIYFCCMM 263
Cdd:cd17319 154 FGWRWAFIIEGLLGLLLAVLWWFYLR----------------------------------------QVWGLALGYFGINY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 264 GLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRL--RERRWHFAAAGLMASVGLLTATIFgSNVG 341
Cdd:cd17319 194 ALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLT-TSPV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 342 LAMVALSLGTAGVLATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNSTNAGIYVIAAALFAGA 421
Cdd:cd17319 273 VAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAA 352
|
....*
gi 576733085 422 CLALF 426
Cdd:cd17319 353 LLVLL 357
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
33-426 |
4.82e-90 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 278.45 E-value: 4.82e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 33 LCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYAT 112
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 113 TPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqglaNWQWLFLL 192
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHF-------SWQWAFII 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 193 EAIPSLILGVVTLMYLPNGIRAAKWLTDTEKQLLEDRIAQDGAGKLN-----AKISRVLGNGRVWFMAAIYFCCMMGLYG 267
Cdd:TIGR00893 154 EGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPstpkkYQIKELLKDRRVWGLALGQFLVNIGLGF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 268 VGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMASVGLL---TATIFGSNVGLAM 344
Cdd:TIGR00893 234 FLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLvlsLLMFATNYVNIPY 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 345 VALSLGTAGV--LATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNSTNAGIYVIAAALFAGAC 422
Cdd:TIGR00893 314 AALALVALGFfgLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGAL 393
|
....
gi 576733085 423 LALF 426
Cdd:TIGR00893 394 SYLL 397
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
22-366 |
1.23e-64 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 212.88 E-value: 1.23e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 22 KVTWRLLPFLFLCYVAAYLDRVNVGFAKLQ-MLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMIT 100
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 101 WALISTGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAfNGV 180
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKI-LGV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 181 QGLANWQWLFLLEAIPSLILGVVTLMYLPNGIRAAKWLTDTEKQLLEDRIAQDGAGKLNAKIS-----RVLGNGRVWFMA 255
Cdd:cd17327 160 GGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKwkqikEAFKDPRTWLLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 256 AIYFCCMMGLYGVGFYLPTLIKAAGvKDALDIGMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLtATI 335
Cdd:cd17327 240 LFFFCSQITNNGISNFLPLILKSLG-FYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSI-ILL 317
|
330 340 350
....*....|....*....|....*....|.
gi 576733085 336 FGSNVGLAMVALSLGTAGVLATMPVFWAWPS 366
Cdd:cd17327 318 AAPNPPGAYFAAYILGGGSYAGFPILLSWIS 348
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-431 |
1.88e-64 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 211.27 E-value: 1.88e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 19 AYSKVTWRLLPFLFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIM 98
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 99 ITWALISTGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFn 178
Cdd:COG2271 83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 179 gvqglaNWQWLFLLEAIPSLILGVVtlmylpngiraakwltdtekqlledriaqdgagklnakisrvlgngRVWFMAAIY 258
Cdd:COG2271 162 ------GWRAAFLILGLPGLLLALL----------------------------------------------RFWLLALAY 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 259 FCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLTATIFGS 338
Cdd:COG2271 190 FLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLP 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 339 NVGLAMVALSLGTAGVLATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTnSTNAGIYVIAAALF 418
Cdd:COG2271 270 SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALAL 348
|
410
....*....|...
gi 576733085 419 AGACLALFQPRER 431
Cdd:COG2271 349 LAALLALLLLRET 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
25-426 |
1.24e-45 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 162.36 E-value: 1.24e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 25 WRLLPFLFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALI 104
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 105 STGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqgla 184
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 185 NWQWLFLLEAIPSLILGVVTLMYLPNgirAAKWLTDTEKQLLEDRIAqdgagklnakisrVLGNGRVWFMAAIYFCCMMG 264
Cdd:COG2223 157 GWRNAFLILGILLLVVAVLAWLFLRD---PPAGAAAAAKASLRDQLE-------------ALRDPRFWLLSLLYFGTFGS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 265 LYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMAsVGLLTATIFGSNVGLAM 344
Cdd:COG2223 221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA-LGLLLLALALGSLWLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 345 VALSLGTAGVLATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNSTNAGIYVIAAALFAGACLA 424
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
|
..
gi 576733085 425 LF 426
Cdd:COG2223 380 LL 381
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-364 |
3.15e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 117.00 E-value: 3.15e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 21 SKVTWRLLPFLFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMIT 100
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 101 WALISTGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngv 180
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF--- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 181 qglaNWQWLFLLEAIPSLILGVVTLMYLPNGIRAAKwltdtekqlledriaqdgaGKLNAKISRVLGNGRVWFMAAIYFC 260
Cdd:COG2814 162 ----GWRWVFLVNAVLALLALLLLLRLLPESRPAAR-------------------ARLRGSLRELLRRPRLLLLLLLAFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 261 CMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLTAtiFGSNV 340
Cdd:COG2814 219 LGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLA--LAGSL 296
|
330 340
....*....|....*....|....
gi 576733085 341 GLAMVALSLGTAGVLATMPVFWAW 364
Cdd:COG2814 297 WLLLLALFLLGFGFGLLFPLLQAL 320
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-425 |
2.40e-28 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 114.83 E-value: 2.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 31 LFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLY 110
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 111 ATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqgLANWQWLF 190
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-----GFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 191 LLEAIPSLILGVVtlmylpngirAAKWLTDTEKQLLEDRIAQDGAGKLNAkISRVLGNGRVWFMAAIYFCCMMGLYGVGF 270
Cdd:cd06174 156 LIAAALALLAAIL----------LLLVVPDPPESARAKNEEASSKSVLKL-LKRVLKNPGLWLLLLAIFLVNLAYYSFST 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 271 YLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLtATIFGSNVGLAMVALSLG 350
Cdd:cd06174 225 LLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLA-LLLLAPSLLLLLLLLLLL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 576733085 351 TAGVLATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNSTNAGIYVIAAALFAGACLAL 425
Cdd:cd06174 304 GFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-393 |
2.38e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 108.66 E-value: 2.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 31 LFLCYVAAYLDRVNVGFA-KLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTL 109
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 110 YATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqglaNWQWL 189
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-------GWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 190 FLLEAIPSLILGVVTlmylpngiraakWLTDTEKQLLEDRIAQDGAGKLNAKISRVLGNGRVWFMAAIyFCCMMGLYGVG 269
Cdd:pfam07690 154 FLILAILSLLAAVLL------------LLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 270 FYLPTLIKAAGVkDALDIGMLTAIPYGCAIVAMLLIARSADRL-RERRWHFAAAGLMASVGLLTATIFGSNVGLAMVALS 348
Cdd:pfam07690 221 TYLPLYQEVLGL-SALLAGLLLGLGGLLGAIGRLLLGRLSDRLgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 576733085 349 LGTAGVLATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSP 393
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
31-427 |
2.83e-20 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 91.46 E-value: 2.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 31 LFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALIS--TGT 108
Cdd:cd17380 4 LFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATllTPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 109 LYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqglaNWQW 188
Cdd:cd17380 84 LAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYY-------GWPS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 189 LFLLEAIPSLILGVVTLMYLPNgiraakwltdtekqlledriaqdgagklnakisrvlgngrVWFMAAIYFCCMMGLYGV 268
Cdd:cd17380 157 VFYFFGLLGLLWALVWLIYLPP----------------------------------------VWAIIVAHFCMNWGFYIL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 269 GFYLPTLIKAAGVKDAlDIGMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAA-GLMASVGLLTATIF----------G 337
Cdd:cd17380 197 LSWLPTYFHEVLVPLA-KGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVrKLMQSIGFLGPALFllllshtdsfS 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 338 SNVGLAMVALSLGT---AGVLATMP---------VFwawpsamlgggaaaagiGLINSVGNLAGFVSPAIVGWTKDVTNS 405
Cdd:cd17380 276 LALLCMSVALGLSAfssSGVLVNHQdiapnyagiVF-----------------GISNTAGTIPGIVGVYLTGYILEATGS 338
|
410 420
....*....|....*....|..
gi 576733085 406 TNAGIYVIAAALFAGACLALFQ 427
Cdd:cd17380 339 WSLVFVLAAVVNLVGAVVFLLF 360
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
32-404 |
3.84e-19 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 88.59 E-value: 3.84e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 32 FLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYA 111
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 112 TTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNGvqglanWQWLFL 191
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYS------WHWVFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 192 LEAIPSLILGVVTLMYLPNGiRAAKWLTDTEKQLLED-----RIAQDGAGKLNAKISRVLGNGRVWFMAAIYFCCMMGLY 266
Cdd:TIGR00881 155 VPGIIAIIVSLICFLLLRDS-PQSCGLPPAEEMPNEEpdgdaEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 267 GVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLRERRWH----FAAAGLMASVGLLTATIFGSNVgl 342
Cdd:TIGR00881 234 GILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGplavFFMALIIVSLLVYWLNPAANPL-- 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 576733085 343 aMVALSLGTAGVLATMPVFWAW--PSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTN 404
Cdd:TIGR00881 312 -MDLICLFALGFLVYGPQMLIGviASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
51-432 |
4.32e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 88.39 E-value: 4.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 51 QMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVwisRIMITWALISTGTL---YATTPTAFYVLRFLLGVA 127
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLER---TLLLALLLLAAGLLlrsLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 128 EAGFFPGIVLYLTYWYPaERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNgvqglanWQWLFLLEAIPSLILGVVTLMY 207
Cdd:COG2807 120 IAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALG-------WRGALAVWALLALLALLLWLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 208 LPNGIRAAkwltdtekqlledriaqdGAGKLNAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVkDALDI 287
Cdd:COG2807 192 LRRRPAAA------------------AAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGL-SAATA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 288 GMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLTATIF-GSNVGLAMVALSLGTAGVLATMPVFWAWps 366
Cdd:COG2807 253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLApGSLPWLWAVLLGLGQGGLFPLALTLIGL-- 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 576733085 367 AMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNSTNAGIYVIAAALFAGACLALFQPRERV 432
Cdd:COG2807 331 RARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPYV 396
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
51-364 |
6.54e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 87.60 E-value: 6.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 51 QMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAG 130
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 131 FFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqglaNWQWLFLLEAIPSLILGVVTLMYLPN 210
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-------GWRAAFLAIAVLALLAALLLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 211 giraakwltdtekqlleDRIAQDGAGKLNAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGML 290
Cdd:cd17324 177 -----------------LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 576733085 291 TAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLTAtiFGSNVGLAMVALSLGTAGVLATMPVFWAW 364
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTL--LGPSPLLLLVGLVLWGLGFFAAHSALQTR 311
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-426 |
4.91e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.32 E-value: 4.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 53 LSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAGFF 132
Cdd:cd17325 23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 133 PGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqglaNWQWLFLLEAIPSLILGVVTLMYLPNGI 212
Cdd:cd17325 103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-------GYRAPFLVCAALALLALVLALLLLPEPR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 213 RAAKWltdtekqlledriAQDGAGKLNAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTA 292
Cdd:cd17325 176 PPPNK-------------RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 293 IPYGCAIVAMLLIARSADRLRERRWhfAAAGLMASVGLLTATIFGSNVGLAMVALSLGTAGVLATMPVFWAWPSAMLGGG 372
Cdd:cd17325 243 AQGLASALSQPPAGKLSDRIGRKPL--ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 576733085 373 AAAAGIGLINSVGNLAGFVSPAIVGWTKDvTNSTNAGIYVIAAALFAGACLALF 426
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
75-428 |
6.82e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 81.85 E-value: 6.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 75 IFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNAL 154
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 155 FMMGIPVAGVIGGPLSGWImqafngvqGLANWQWLFLLEAIpSLILGVVTLMYLPngiraakwltdtekqllEDRIAQDG 234
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGAL--------AEIGWRAPFLVYLL-ALPVLILVLLFLP-----------------EPARKSKS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 235 AGKLNAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLRE 314
Cdd:cd17473 183 AASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 315 RRWHFAAAGLMAsVGLLTATIfGSNVGLAMVALSLGTAGVLATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSPA 394
Cdd:cd17473 263 RRLLAIGFALMA-LGFLLLAL-ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
|
330 340 350
....*....|....*....|....*....|....
gi 576733085 395 IVGWTKDVTNSTNAGIYVIAAALFAGACLALFQP 428
Cdd:cd17473 341 VLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
87-425 |
1.50e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 74.56 E-value: 1.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 87 RFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIG 166
Cdd:cd17316 62 RIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 167 GPLSGWIMQAFNGVQGlanWQWLFLLEAIPSLILgvvtlmylpngiraakwltdtekqlledriaqdgagklnakisrVL 246
Cdd:cd17316 142 ALVASLLIPLLSGDWG---WRILFLIGALPALLA--------------------------------------------LL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 247 GNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMA 326
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 327 SVGLLTATIFGSNVGLAMVALSLGTAGVLATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNST 406
Cdd:cd17316 255 ILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGT 334
|
330
....*....|....*....
gi 576733085 407 NAGIYVIAAALFAGACLAL 425
Cdd:cd17316 335 GVPALILALLAIVALIVAL 353
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
58-398 |
1.10e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 72.39 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 58 FSDTVYGLGAGIFFIGYiffevpsnvLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAGFFP-GIV 136
Cdd:TIGR00895 58 FSAGLIGMAFGALFFGP---------LADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPnLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 137 LYLTYWyPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqglaNWQWLFLLEAIPSLILGVVTLMYLPNGIR-AA 215
Cdd:TIGR00895 129 LVSEYA-PKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF-------GWRSLFYVGGIAPLLLLLLLMRFLPESIDfLV 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 216 KWLTDTEKQLLEDRIAQDGAGKLNA--KISRVLGNGRVWFMA--------------AIYFCCMMGLYGVGFYLPTLIKAA 279
Cdd:TIGR00895 201 SKRPETVRRIVNAIAPQMQAEAQSAlpEQKSTQGTKRSVFKAlfqgktaritvllwLLYFMLLVGVYFLTNWLPKLMVEL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 280 GVKDALDIGMLTAIPYGcAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLTATIFGSNVGLAMVAL-----SLGTAGV 354
Cdd:TIGR00895 281 GFSLSLAATGGALFNFG-GVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIagffvNGGQSGL 359
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 576733085 355 LATMPVFWAwpsamlgGGAAAAGIGLINSVGNLAGFVSPAIVGW 398
Cdd:TIGR00895 360 YALMALFYP-------TAIRATGVGWAIGIGRLGAIIGPILAGY 396
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
50-426 |
1.47e-13 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 71.90 E-value: 1.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 50 LQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVW--ISRIMITWALISTGtLYATTPTAFYVLRFLLGVA 127
Cdd:cd17341 23 PVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVfiASLLLLLIPLLALA-LAVSSYWGLLVLGFLLGFA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 128 EAGFFPGIVlYLTYWYPAERRSRVNalfmMGIPVAGVIGGPLSG----WIMQAFNGVQGLANWQWLFLLEAIPSLILGVV 203
Cdd:cd17341 102 GANFASGQP-WASFWFPKEKIGGAA----GGIAGAGNMGVAVSQllapLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 204 TLMylpngiraakWLTDTEKQLledriaqDGAGKLNAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKD 283
Cdd:cd17341 177 VLL----------FGDDLPTGK-------ASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 284 ALDIGMLTAIPYGCAIVAMLLIARSADRLRERR---WHFAAAGLMASVGLLTATIFGSNVGLA---MVALSLGTAGVLAT 357
Cdd:cd17341 240 LVTAGILAALFPLAGALARPAGGWLSDRFGGRRrlwWLFIVMTIGAALLSLSLPTSGTNLVLFlalFVALGLGAGAGNGS 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 576733085 358 mpVFWAWPSAMLGGGAAAAGIGLinSVGNLAGFVSPAIVGWTKDVTNSTNAGIYVIAAALFAGACLALF 426
Cdd:cd17341 320 --VFRMVPFIFRRELGAVTGLVG--AIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
51-431 |
4.79e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 70.27 E-value: 4.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 51 QMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAG 130
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 131 FFPGIVLYLTYWYPAERRSRVNaLFMMGIPVAGVIGGplsgWIMQAFNGVQGLANWQWLFLLEAIPSLILGVVTLMYlpn 210
Cdd:COG0738 113 LDVAANPYVAALGPETAASRLN-LLHAFFSLGALLGP----LLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRS--- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 211 giraakwltdtekQLLEDRIAQDGAGKLNAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGML 290
Cdd:COG0738 185 -------------KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 291 TAIPYGCAIVAMLLIARSADRLRERRWhFAAAGLMASVGLLTAtIFGSNVGLAMVALSLGTAGVLATMPVFWAWpSAMLG 370
Cdd:COG0738 252 LSLFWGGMTIGRFLGGFLLKRFGPVRL-LRLSALLAAVGLLLA-LLAPGPWLALIGLALVGLGLSLMFPTIFSL-ALDGL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 576733085 371 GGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTnSTNAGIYVIAAALFAGACLALFQPRER 431
Cdd:COG0738 329 GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLLILLLALALKRKR 388
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
31-419 |
5.97e-13 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 69.96 E-value: 5.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 31 LFLCYVAAYLDRVNVGFAKLQM-----------LSDLKFSDTVY-----------GLGAGIFFIGYIFFEVPSNVLMHRF 88
Cdd:cd17318 4 LFLGFAVVYAMRVNLSVAIVAMvnstathdnnnTSTDKDTLPVEapefdwsektqGIILSSFFYGYILTQIPGGYLAEKY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 89 GARvwisrIMITWALISTGTLYATTP-------TAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPV 161
Cdd:cd17318 84 GAK-----RVLGYSILITALLTLLTPlaarggyGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 162 AGVIGGPLSGWIMQAFngvqglaNWQWLFLLEAIPSLILGVVTLMYLPngiraakwltdtekqlledriaqdgagklnak 241
Cdd:cd17318 159 GTVIAMPLSGFLCESL-------GWPSIFYIFGGLGLLWCLLWFFLVL-------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 242 isrvlgngRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLReRRWHF-- 319
Cdd:cd17318 200 --------PVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLR-SRGILst 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 320 --------AAAGLMASVGLLTATIFGSNVGLAMVALSLG-------TAGVLATM----PVFwawpsamlgggaAAAGIGL 380
Cdd:cd17318 271 ttvrklftSIGFLGPGVFLIALGYLGSNATLAVVFLTLSvglsgacYSGFLVNHldlaPNY------------AGTLMGI 338
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 576733085 381 INSVGNLAGFVSPAIVGW-TKDVTNSTN--------AGIYVIAAALFA 419
Cdd:cd17318 339 TNTAATIAGIISPLIVGAiVKNDQTIGQwrivffisAAIYILGAIFYL 386
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
28-357 |
6.45e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 66.88 E-value: 6.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 28 LPFLFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGaRVWISRIMIT-WALIST 106
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVGILiWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 107 GTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNGvqglanW 186
Cdd:cd17328 80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGG------W 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 187 QWLFLLEAIPSLILGVVTLMYLPNGIRAAkwltdtekqlledriAQDGAGKLNAKIS------RVLGNGRVWFMAAIYFC 260
Cdd:cd17328 154 RWAFRVTGVLGVLLAILLLLFVREPPRGA---------------AEGGVMAKSTATSfladlkALAKNPSFILSTLGFTA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 261 CMMGLYGVGFYLPTLIK---AAGVKDALDIGM-LTAIPYGCAIVAMLLIARSADRLRERRWH----FAAAGLMASVGLLT 332
Cdd:cd17328 219 VSFVTGALAFWAPTFFLrafGVGDLSSADVGLiFGAITCIAGVLGVLLGGILADRLRRKTPRadplVCAVGLLAAAPFLF 298
|
330 340
....*....|....*....|....*..
gi 576733085 333 ATIFG--SNVGLAMVALSLGTAGVLAT 357
Cdd:cd17328 299 LALVLalSNLLLAWVLLFLGEFLLSLN 325
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
25-306 |
9.99e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 65.22 E-value: 9.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 25 WRLLPFLFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALI 104
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 105 STGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqgla 184
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 185 NWQWLFLLEAIPSLILGVVTLMYLPNGIRAAKWLTDTEKQLLEDRIAQDGAGKLNAKISRVLGNGRVWFMAAIYFCCMMG 264
Cdd:COG0477 166 GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 576733085 265 LYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIA 306
Cdd:COG0477 246 LLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
31-421 |
1.09e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 65.68 E-value: 1.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 31 LFLCYVAAYLDRVNV---GFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTG 107
Cdd:cd17365 1 LALCFLIIVLDGFDLavmGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 108 TLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqglaNWQ 187
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF-------GWR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 188 WLFLLEAIPSLILGV---VTLMylpngiraakwltdtekqlledriaqdgagklnakisrvlgngrvwfMAAIYFCCMMG 264
Cdd:cd17365 154 SVFLLGGVPPLILLPllrGTLL-----------------------------------------------LWVTFFMGLLL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 265 LYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGcAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLTATIFGSNVGLAM 344
Cdd:cd17365 187 VYLLNSWLPKLMVEAGYSLSQALTITLLLNIG-GVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYV 265
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 576733085 345 VALSLGtAGVLATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNSTNAGIYVIAAALFAGA 421
Cdd:cd17365 266 LVFLAG-ACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGA 341
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
51-428 |
1.77e-10 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 62.32 E-value: 1.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 51 QMLSDLKFSDTVYGLGAGIFFIGYIffevpSNVLMHRFGARVWISRIMITWALISTGTL-----YATTPTAFYVLRFLLG 125
Cdd:cd06180 24 LMLAELGLSYAQAGWIATANYAGYL-----VGALLASFLRRRGRARRLIRGGLLLTVLLlaamaLTSGFAALLALRFLAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 126 VAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLsgwimqAFNGVQGLANWQWLFLLEAIPSLILGVVTL 205
Cdd:cd06180 99 AASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLL------VPAGLGGGLSWRAGWLALALLSAVLLLLSF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 206 MYLPNGIRAAkwltdTEKQLLEDRIAQdgagklnakisrvlgNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKdAL 285
Cdd:cd06180 173 LLLRRGPSAP-----TEASAAESAPGL---------------NRPLWRLALAYGLFGFGYIITATFLPLIARETGAG-SL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 286 DIGMLTAIPYGCAIVAMLLIARSADRLRERRWhFAAAGLMASVGLLTATIFGSNVGLAMVALSLG---TAGVLATMP-VF 361
Cdd:cd06180 232 LAGLLWSLFGLAAVPSCFLWGALSDRWGTRRA-LAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGgtfMAITALVMAlAR 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 576733085 362 WAWPSAMLGGGAAAAGIGlinSVGNLAGfvsPAIVGWTKDVTNSTNAGIYVIAAALFAGACLALFQP 428
Cdd:cd06180 311 ELAPPAAPRALALMTASF---GVGQILG---PLLAGWLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
52-364 |
2.33e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.84 E-value: 2.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 52 MLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAGF 131
Cdd:cd17489 22 YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 132 FPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNGvqglanwQWLFLLEAIPSLiLGVVTLMYLPNG 211
Cdd:cd17489 102 TTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGF-------AVLFIVAAVLAL-LALLLVFLVKDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 212 IRAAKWLTDTEKQLLEDRIaqdgagklnakisrvlgNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLT 291
Cdd:cd17489 174 PPVAAEEAEAGTRAFRRLV-----------------EKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVY 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 576733085 292 AIpygCAIVAMLLIARSADRLRERRwhFAAAGLMASVGLLTATIFGSNVGLAMVALSLGTAGVLATMPVFWAW 364
Cdd:cd17489 237 AI---ALLLSRPFSGKLSDRKGPKT--VIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQAL 304
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
146-363 |
5.91e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.07 E-value: 5.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 146 ERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNGVQGlANWQWLFLLEAIPSLILGVVTLMYLPngiraakwltdtekql 225
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAA-LGYRLTALIFAVLGLLAFLLTFFGTK---------------- 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 226 lEDRIAQDGAGKLNAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLI 305
Cdd:COG2211 206 -ERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLW 284
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 576733085 306 ARSADRLRERRWHFAAAGLMASVGLLTATIFGSNVGLAMVALSLGTAGVLATMPVFWA 363
Cdd:COG2211 285 PRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWA 342
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
24-427 |
9.30e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 56.90 E-value: 9.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 24 TWRLLPFLFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWAL 103
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 104 ISTGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqgl 183
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 184 aNWQWLFLLEAIPSLILGVVTLmylpngiraaKWLTDTEKqlledriaqdgagklnakisrvlgngRVWFMAAIYFCCMM 263
Cdd:cd17312 155 -GWRAAFLVPGIVGLVVAIILF----------FFLRDSPP--------------------------YVWVLSLAYAFVYI 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 264 GLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLTATIFGSNVGLA 343
Cdd:cd17312 198 VRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 344 MVALSLGTAGVLATMPV-FW--AWPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNSTNAGIYVIAAALFAG 420
Cdd:cd17312 278 LSIVLLFLIGFFVGGPInLIggAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSV 357
|
....*..
gi 576733085 421 ACLALFQ 427
Cdd:cd17312 358 LLLLSLW 364
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
25-426 |
2.14e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 55.74 E-value: 2.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 25 WRLLPFLFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARvwisRIMITWALI 104
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPR----RVMLLGLLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 105 STGTL----YATTPTAFYVLRFLLGVAEAG-FFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNg 179
Cdd:cd17355 78 LAAGLvllaLATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 180 vqglanWQWLFLLEAIpsLILGVVTLMYLpngiRAAKWLTDTEKQLLEDRIAQDGAGKLNAkisrVLGNGRVWFMAAIYF 259
Cdd:cd17355 157 ------WRTALLVLAL--LALLVLVPVLL----LLRRRPADLALRAYDDASPASPGSTLKE----ALRSASFWLLALAFF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 260 CCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIpYGCAIVAMLLIARSADRLrERRWHFAAAGLMASVGLLTATIFGSN 339
Cdd:cd17355 221 LCGFAVVGLIVHLVPYLADRGISPAAAAVALALI-GLFNIVGRLLSGWLGDRY-SPRRLLAASYALRALGLALLLLLPFP 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 340 VGLAMVALSLGTAGVLATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNSTNAGIYVIAAALFA 419
Cdd:cd17355 299 PLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLI 378
|
....*..
gi 576733085 420 GACLALF 426
Cdd:cd17355 379 AALLVLP 385
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
52-425 |
3.87e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.94 E-value: 3.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 52 MLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAGF 131
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 132 FPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNgvqglanWQWLFLLEAIPSLILGVVTLMYLPNg 211
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG-------WRAAFVVAGLVSILAAVLFWLFYRE- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 212 IRAAKWLTDTEKQLLedriaqdgagklnAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLT 291
Cdd:cd17475 174 PPAASAATESASTLL-------------RSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 292 AIPYGCAIVAMLLIARSADRLRERRWH-------FAAAGLMASVGLLTAtifGSNVGLAMVALSLGTAGVLATMPVFWAW 364
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSDRVFGGRRRpvlvitaAIAAAALLVLSLLSP---GTPLWLLVLLLILLGLFAIGWNGLYLTL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 576733085 365 PSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNSTNAGIYVIAAALFAGACLAL 425
Cdd:cd17475 318 VAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
47-361 |
4.50e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.46 E-value: 4.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 47 FAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGV 126
Cdd:cd17329 21 FMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 127 AEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWImqafngvqGLANWQWLFLLEAIPSLILGVVTLM 206
Cdd:cd17329 101 GGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL--------LLYSFRLLFLAAAVLFLLAALVLLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 207 YLPNGIraakwLTDTEKQLLEDRIAqdgagklnakISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALD 286
Cdd:cd17329 173 LLPETR-----PKRRAAEKTEILRG----------YKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 576733085 287 IGMLTAIPYGCAIVAMLLIARSADRLRERRWhFAAAGLMASVGLLTATIFGSNVGL--AMVALSLGTAGVLATMPVF 361
Cdd:cd17329 238 LGLLLALNALLIVLLQFPVARLVERFRLRKI-LMIGILLFAIGFAVLAFANTLAVLilAMIVLTLGEMLVFPAVQTL 313
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
54-332 |
5.05e-07 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 51.53 E-value: 5.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 54 SDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTP-TAFYVLRFLLGVAEAGFF 132
Cdd:TIGR00886 30 DDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSySVLLLIRLFIGIAGGSFA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 133 PGIVLyLTYWYPAERRSRVNALFM----MGIPVAGVIGGPLSGWIMQAfNGVQGLANWQWLFLLeaIPSLILGVVTLMYL 208
Cdd:TIGR00886 110 SCMPW-ISFFFPKKIQGTALGLAAgwgnMGGGVAQFVMPPIIGSLIFG-GGQPAHLAWGWAFVI--VPAGILLLPALLIF 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 209 PNGIraakwltDTEKQLLEDRIAQDGAGKlnakisRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIG 288
Cdd:TIGR00886 186 FVGA-------DTPPGKPATGKLSFKEAL------KVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAG 252
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 576733085 289 MLTAIPYGCAIVAMLLIARSADRL-RERRWHFAAAGLMASVGLLT 332
Cdd:TIGR00886 253 AYASLGGFLGSLARPAGGAISDRLgGARKLLMNFLGVAMGAFLVV 297
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
51-426 |
6.07e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 6.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 51 QMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARvwisRIMITWALI----STGTLYATTPTAFYVLRFLLGV 126
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRK----KVLLPGLLLfgigGLLCGLSDSFALLLAGRALQGI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 127 AEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWImqafngvqGLANWQWLFLLEAIPSLILGVVTLM 206
Cdd:cd17474 100 GAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL--------AAISWRYPFFLLAALIPVAFLAILF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 207 YLPNgiraakwltdtekqllEDRIAQDGAGKLNAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALD 286
Cdd:cd17474 172 LLPE----------------PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPII 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 287 IGMLTAIPygcaIVAMLLIARSADRLRERRWHFA---AAGLMASVGLLTATIFGSNVGLAMVALSLGTAGVLATMPVFWA 363
Cdd:cd17474 236 IGLLFAGW----SVLLALGSLFVGRLLKKRFGARrilVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 576733085 364 WPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNSTnaGIYVIAAALFAGACLALF 426
Cdd:cd17474 312 LVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLS--APFLVGAAIALAAAVLLA 372
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
69-351 |
6.27e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.17 E-value: 6.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 69 IFFIGYIFFEVPSNVLMHRFGarvwiSRIMITWALISTGTLYATTPTA-----FYVLRFLLGVAEAGFFPGIVLYLTYWY 143
Cdd:cd17333 39 SQNAGYLIGSLLAGFLMKRLG-----RRRTLILGLLLISLALALIFATpsiylFVVLMFLAGLGAGILDTGANTFVGALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 144 P---AERRSRVNALFMMGIPVAGVIGGPLsgwimqafngVQGLANWQWLFLLEAIPSLILGVVTLMylpngiraAKWltd 220
Cdd:cd17333 114 EessATRLNVLHGFFGLGALIGPLIATSL----------LTSELSWSWAYLIIGLIYLLLAILILL--------TLF--- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 221 teKQLLEDRIAQDGAGKLNAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIV 300
Cdd:cd17333 173 --PELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITI 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 576733085 301 AMLLIARSADRLRERRWHFAAAGLmASVGLLTATIFGSNVGLAMVALSLGT 351
Cdd:cd17333 251 GRLLGGPISRRIKPHTLLVLSGSG-ALLGLLILLLAPTLVVGLVATALLGL 300
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
102-354 |
9.26e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.63 E-value: 9.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 102 ALISTGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvq 181
Cdd:cd17321 72 GLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF---- 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 182 glaNWQWLFLLeaipSLILGVVTLmylpngiraakwltdtekqlledriaqdgagklnakisrVLGNGRVWFMAAIyFCC 261
Cdd:cd17321 148 ---GWRWIFLI----NVPIGLVAL---------------------------------------LLARTFSGAVLAA-FLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 262 MMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLRERRwhFAAAGL-MASVGLLTATIFGSNV 340
Cdd:cd17321 181 GAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRL--VLVAGLlLTAVGLLLLALLGADS 258
|
250
....*....|....
gi 576733085 341 GLAMVALSLGTAGV 354
Cdd:cd17321 259 SVWLLLPGLVLLGL 272
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
25-361 |
9.30e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 50.70 E-value: 9.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 25 WRLLPFLFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALI 104
Cdd:cd17345 2 WQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 105 StgTLYATTPTA------FYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFn 178
Cdd:cd17345 82 N--ILIGFVPSAtssvglMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIF- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 179 gvqGLANWQWLFLLEAIPSLILGVVTLMY---------LPngiRAAKWLTDTEKQLLEDRIAQDgagkLNAK---ISRVL 246
Cdd:cd17345 159 ---GDGWWRGAFIFPAIIAIIVAVIVLFLgkdtpesegLP---PIEEYKGDYPEEADGEEEEQE----LSAWeifVKYVL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 247 GNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRL-RERRwhfAAAGLM 325
Cdd:cd17345 229 KNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfKGRR---APTGII 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 576733085 326 ASVGLLTATI---FGSNVGLAMVALSLgtAGVLATMPVF 361
Cdd:cd17345 306 FMILVIVALIvywLAPNVLVDLIALIA--LGFLIYGPVM 342
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
53-358 |
2.20e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.53 E-value: 2.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 53 LSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGAR--VWISRIMITwALISTGTLYATTPTAFYVLRFLLGVAEAG 130
Cdd:cd17490 23 AESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRklFIIIGLLFT-VLASLIMILFPSPWGLLIARFLSGIAAAT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 131 FFPGIVLYLTYwYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqglaNWQWLFLLEAIPSLILGVVTLMylpn 210
Cdd:cd17490 102 WVSFTVLYASY-FPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHF-------GMRAPFLLAALAGVLGFILSLF---- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 211 giraakwltdtekqLLEDRIAQDGAGKLNAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGML 290
Cdd:cd17490 170 --------------IKEERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLL 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 576733085 291 TAIPYGCAIVAMLLIARSA-DRLRERRWHFAAAGLMASVGLLTATIFGSNVGLAMVALSLGTAGVLATM 358
Cdd:cd17490 236 SIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPL 304
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
52-208 |
3.47e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 48.73 E-value: 3.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 52 MLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAGF 131
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 576733085 132 FPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqglaNWQWLFLLEAIPSLILGVVTLMYL 208
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-------GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
87-428 |
3.56e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 48.84 E-value: 3.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 87 RFGaRVWISRIMITWALISTGTL-YATTPTAFYVLRFLLGVAEAGFFP-GIVLYLTYWyPAERRSRVNALFMMGIPVAGV 164
Cdd:cd17371 60 RFG-RVRVLVITILLFAVFTLLCgFAQNYWQLLILRALAGLGFGGEWAaGAALMAEYV-PARHRGKALGYVQSGWAVGWL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 165 IGGPLSGWIMQAFNGVQGlanWQWLFLLEAIPSLILGVVtlmylpngiraAKWLTDTE---KQLLEDRIAQDGAGKLNAK 241
Cdd:cd17371 138 LATLLAALLFPLLPPEIA---WRVLFLLGALPALLVLFI-----------RRFVKEPPqwqAARAARRHFADRPSLRELF 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 242 ISRVLGNGRVWFMAAIyfCCMMGLYGVGFYLPTLIKaaGVKDALDIGMLT--AIPYGCAIVAMLLIARSADRLrERRWHF 319
Cdd:cd17371 204 SPPLLRTTLLASLLAT--GALGGYYGITTWLPSYLT--GERGLSFEGSAGylVVTILGGFLGYLAGGFLADRI-GRRNNF 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 320 AAAGLMASVGLLTATIFGSNVGLAMVALSLGTAGVLATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWT 399
Cdd:cd17371 279 ALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFL 358
|
330 340
....*....|....*....|....*....
gi 576733085 400 KDVTNSTNAGIYVIAAALFAGACLALFQP 428
Cdd:cd17371 359 ATSGSLGTAIAVFAAVYYIAGLVLALLLP 387
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
84-349 |
4.04e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.73 E-value: 4.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 84 LMHRFGARvwisRIMITWALISTGTLY----ATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGI 159
Cdd:cd17503 54 LADRFGTR----RLFLTALALFTLGSLlcglAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVI 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 160 PVAGVIGGPLSGWIMQAFngvqglaNWQWLFLLeaipSLILGVVTLMYLPngiraakwltdtekqLLEDRIAQDgagkln 239
Cdd:cd17503 130 LLAPAIGPTLGGWLTDNL-------SWRWIFYI----NLPIGILALLLAP---------------LLDLRLFKD------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 240 akisRVLGNGrvwfmAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTaIPYGCA-IVAMLLIARSADRLRERRWH 318
Cdd:cd17503 178 ----RNFTLG-----LLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVL-APGGLAsAILSPLVGRLLDKFGPRLLL 247
|
250 260 270
....*....|....*....|....*....|.
gi 576733085 319 FAAAGLMAsVGLLTATIFGSNVGLAMVALSL 349
Cdd:cd17503 248 LAGLLLLA-LGTLLLAFLTPDTSLWLIILPL 277
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
130-216 |
1.20e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 47.37 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 130 GFFPGIVLYLTYW-----YPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqglaNWQWLFLLEAIPSLILGVVT 204
Cdd:TIGR00711 101 GFGGGPLIPLSFStllniYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENY-------HWRWIFLINVPIGIIVVVVA 173
|
90
....*....|..
gi 576733085 205 LMYLPNGIRAAK 216
Cdd:TIGR00711 174 FFILPRDKPAAS 185
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
26-208 |
1.20e-05 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 47.02 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 26 RLLPFLFLCYVAAYLDRVNVGFAKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALIS 105
Cdd:cd17488 3 HILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 106 TGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFngvqglaN 185
Cdd:cd17488 83 ILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTY-------G 155
|
170 180
....*....|....*....|...
gi 576733085 186 WQWLFLLEAIPSLILGVVTLMYL 208
Cdd:cd17488 156 WRAGMYVPGIIAILMGIVLCWRL 178
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
68-352 |
1.53e-05 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 47.08 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 68 GIFFIGYIFFEVPSNVLMHRFGARvwisrIMITWALISTGTLYATTPTA-------FYVLRFLLGVAEAGFFPGIVLYLT 140
Cdd:cd17381 72 GSFFYGYIITQIPGGYLASKIGGK-----LLLGFGILGTAVFTLLTPLAadlgagyLIAVRALEGLGEGVTFPAMHAMWA 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 141 YWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNgvqglanWQWLFLleaipslILGVVTLMYLPNGIraakWLTD 220
Cdd:cd17381 147 SWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLD-------WTYVFY-------IFGAVGLLWFFLWI----WLVM 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 221 TekqlledriaqdgagklnakisrvlgngrVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIV 300
Cdd:cd17381 209 P-----------------------------LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWL 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 576733085 301 AMLLIARSADRLRER--------RWHFAAAGLMA-SVGLLTATIFGSNVGLAMVALSLGTA 352
Cdd:cd17381 260 FMILSGQIADNLREKqnfstvcvRKIFTLIGMIGpAVFLLAAGFTGCNYSLAVAFLTISST 320
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
59-361 |
2.48e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 59 SDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVW-----ISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAGFFP 133
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 134 GIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNGVqglanwqWLFLLEAIpSLILGVVTLMYLPNgir 213
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPG-------GAFAINAL-SFLLSALLLLFIRR--- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 214 aakwltdtEKQLLEDRIAQDGAGKLNAKISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAI 293
Cdd:cd06173 181 --------PPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAA 252
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 576733085 294 PYGCAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLTATIFGSNVGLAMVALsLGTAGVLATMPVF 361
Cdd:cd06173 253 FGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFL-LGLAGGLFNVPLN 319
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
54-362 |
4.56e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 45.34 E-value: 4.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 54 SDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWI---SRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAG 130
Cdd:pfam00083 39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLliaNVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 131 FFPGIVLYLTYWYPAERRSRVNALFMMGIpvagVIGGPLSGWIMQAFNGVQGLANWQWLFLLEAIPSLILgVVTLMYLPN 210
Cdd:pfam00083 119 ASVLAPMYISEIAPKKLRGALGSLYQLAI----TFGILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLL-IIGLLFLPE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 211 GIR----------AAKWLTDTEKQLLEDRIAQDGAGKLNAKISR--------VLGNGRVW--FMAAIYFC--CMMGLYGV 268
Cdd:pfam00083 194 SPRwlvekgrleeAREVLAKLRGVPDVDRELDEIKDSLEAGQEAekaswkelFSTKTRRQrlLIGVMLQIfqQLTGINAI 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 269 GFYLPTLIKAAGVKDaldiGMLTAIPYGCAIVAMLLIA-RSADRLRERRWH-------FAAAGLMASVGLLTATIFGSNV 340
Cdd:pfam00083 274 FYYSTTIFENLGLSD----SFLVTIIVGVVNFVFTFIAiFLVDRFGRRPLLllgaagmAICFVILGIVALLGVSKSDWAG 349
|
330 340
....*....|....*....|...
gi 576733085 341 GLAMVALSLGTAGVLATM-PVFW 362
Cdd:pfam00083 350 IVAIVFIALFIAFFAMGWgPVPW 372
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
52-428 |
5.10e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 5.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 52 MLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVwisrIMITWALISTGTLYATTP-TAFYVLRFLLGVAeAG 130
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRP----VAIAGGLLAALGLLLSSFaTSLWQLYLTYGVL-GG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 131 F-----FPGIVLYLTYWYpAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNgvqglanWQWLFLLEAIPSLILGVVTL 205
Cdd:cd17352 104 LglgliYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG-------WRGALLILGGLCLNLCVCGL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 206 MYlpngiraakwltdtekqlledriaqdgagklnakisRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVkDAL 285
Cdd:cd17352 176 LL------------------------------------RLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGI-DES 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 286 DIGMLTAIPYGCAIVAMLLIARSADRLRERRWH-FAAAGLMASVGLLTATIFGSNVGLAMVALSLG--TAGVLATMPVFW 362
Cdd:cd17352 219 DAAFLLSIIGISDIVGRILLGLLADKPRIGRLYlYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGfcSGSYSSLTPVIL 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 576733085 363 AWPSAMLGGGAAAAGIGLINSVGNLAGfvsPAIVGWTKDVTNSTNAGIYVIAAALFAGACLALFQP 428
Cdd:cd17352 299 ADLVGLEKLSNAYGLVLLFQGLAALVG---PPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
69-332 |
6.73e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 45.01 E-value: 6.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 69 IFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERR 148
Cdd:TIGR00898 135 CFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQR 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 149 SRVNALFMMGIPVaGVIGGPLSGWIMQafngvqglaNWQWLFLLEAIPSlILGVVTLMYLPNGIRaakWL------TDTE 222
Cdd:TIGR00898 215 AIVGTLIQVFFSL-GLVLLPLVAYFIP---------DWRWLQLAVSLPT-FLFFLLSWFVPESPR---WLisqgriEEAL 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 223 KQLleDRIAQDGAGKLNAKISRV---------------LGNGRVWFMAAIYFCCMMGLYGVGFY---LPTLIKAAGVKDA 284
Cdd:TIGR00898 281 KIL--QRIAKINGKKLPAEVLSLslekdlssskkqysfLDLFRTPNLRKTTLCLMMLWFTTAFSyygLVLDLGNLGGNIY 358
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 576733085 285 LDIGMLTAIPYGCAIVAMLLIarsaDRLrERRWHFAAAGLMASVGLLT 332
Cdd:TIGR00898 359 LDLFISGLVELPAKLITLLLI----DRL-GRRYTMAASLLLAGVALLL 401
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
42-177 |
1.89e-04 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 43.48 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 42 RVNVGFAKLQMLS---DLKFSDTVY------------GLGAGIFFIGYIFFEVPSNVLMHRFGARvwisrIMITWALIST 106
Cdd:cd17382 15 RCNLGVAIVRMVNnftDAYGGKVIVhkaefnwtpetvGLIESSFFWGYLVTQIPGGFIAAKFAAN-----RVFGLAIFVT 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 576733085 107 GTLYATTPTAFYV-------LRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAF 177
Cdd:cd17382 90 STLNMLIPIAARVhygcvifVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYV 167
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
48-205 |
3.38e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.55 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 48 AKLQMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARvwisRIMITWALI----STGTLYATTPTAFYVLRFL 123
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRR----KTLLISAVLffisALGSAFSPNFTIFIIARII 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 124 LGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIpVAGVIGGPLSGWIMQAF--NGVQGLANWQWLFLLEAIPSLILG 201
Cdd:cd17359 99 GGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMI-VFGQLLAYIVNYLIANAggADWLGAEGWRWMLGLEAIPAILFL 177
|
....
gi 576733085 202 VVTL 205
Cdd:cd17359 178 LGML 181
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
51-425 |
4.08e-04 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 42.36 E-value: 4.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 51 QMLSDLKFSDTVYGLGAGIFFIGYIffeVPSNVLMHRFGARVWISRIMITWALISTGTLYATT-----PTAFYVLRFLLG 125
Cdd:pfam06779 18 VMIAEGQFSLSQAGLLAAANYAGYL---AGALLASFAWRHGASRLRPALLAGLLATVLLLLAMaatssFWAVLLIRFLAG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 126 VAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGiPVAGVIGGPLSGWIMQAFnGVQGLANWQWLFLLEAIPSLILGVVTL 205
Cdd:pfam06779 95 VASAAVMIFGSSLILGHATAARRAFVGALLFAG-VGIGIALSGLLVPLGLQL-GLGGSSLWYGAGVLSAVLTLAVFPLLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 206 MYLPNGIRAAKWLTDTEKQLLEdriaqdgagklnakisrvlgngrVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDAL 285
Cdd:pfam06779 173 RRAPRHASAPAPAAKPLQRSLP-----------------------LWILTLAYGLAGFGYIITATFLPAMARDGFGGPAA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 286 diGMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLTATIFGSNVGLAMVALSLG---TAGVLATMPV-- 360
Cdd:pfam06779 230 --AALFWSLFGLAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGgtfMAITSLVMQLar 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 576733085 361 FWAWPSAMLGGGAAAAGIglinSVGNLAGfvsPAIVGWTKDVTNSTNAGIYVIAAALFAGACLAL 425
Cdd:pfam06779 308 ELAPPAPRRLLGLMTASF----GIGQILG---PLLASLLTAATGGLTPALLLAAAALVLAALIVL 365
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
58-209 |
1.08e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 58 FSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARvwisRIMITWALISTGTL----YATTPTAFYVLRFLLGVAEAGFFP 133
Cdd:cd17477 28 VSTALIGLVASAYYLGILLGSPLVPRLIRRVGHI----RAFAAGAAITAVSVlllaLTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 576733085 134 GIVLYLTYWYPAERRSRVNALFMMGIpVAGVIGGPLSGWIMqafngvqGLANWQWLFLLEAIPSLILGVVTLMYLP 209
Cdd:cd17477 104 VSESWLNALATNENRGRVLGLYSTVL-GLGFALGPLLLALV-------GTAGALPFLIAAVLLLLALVPLLLTRRA 171
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
257-434 |
1.23e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 257 IYFCCMMGLYGVGFYLPTLIKAAGVkDALDIGMLTAIPYGCAIVAMLLIARSADRLRERRWHFAAAGLMASVGLLTAtiF 336
Cdd:cd06174 4 GFFLTGLARGLISPLLPALLQSFGL-SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA--F 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 337 GSNVGLAMVALSLGTAGVLATMPVFWAWPSAMLGGGAAAAGIGLINSVGNLAGFVSPAIVGWTKDVTNSTNAGIYVIAAA 416
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170
....*....|....*...
gi 576733085 417 LFAGACLALFQPRERVNN 434
Cdd:cd06174 161 LALLAAILLLLVVPDPPE 178
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
102-358 |
1.24e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.02 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 102 ALISTGTLYATTPTAFYVLRFLLGVAEAGffpGIVLYLTY---WYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFn 178
Cdd:cd17320 75 ILASLLCALASSIEQLLIARFLQGLGAAA---GSVVARAIvrdLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 179 gvqglaNWQWLFLLEAIPSLILGVVTLMYLPngiraakwltdtEKQLLEDRIAQdgAGKLNAKISRVLGNGRVWFMAAIY 258
Cdd:cd17320 151 ------GWRAIFVFLALLGLLLLLLVLLFLP------------ETLPEEKRKPL--LSSLLRAYKRVLKNRRFLGYALAL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 259 FCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPYGCAIVAMLLIARSADRLRERR-WHFAAAGLMAS-VGLLTATIF 336
Cdd:cd17320 211 GLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRlLRLGLLLLLAAaLVLLLAALL 290
|
250 260
....*....|....*....|..
gi 576733085 337 GSNVGLAMVALSLGTAGVLATM 358
Cdd:cd17320 291 GGLSLWPLVAPLFLIFFGFGLI 312
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
25-204 |
1.60e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.62 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 25 WRLLPFLFL-CYVAAYLDRVNVGFAKLQMLSdLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARvwisRIMITWAL 103
Cdd:cd17477 187 LRIAPLALLgAFVAGFLEGAFYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRR----RVLLGCAL 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 104 ISTG-----TLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFN 178
Cdd:cd17477 262 LGALaalllPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG 341
|
170 180
....*....|....*....|....*.
gi 576733085 179 GvqglanwQWLFLLEAIPSLILGVVT 204
Cdd:cd17477 342 P-------HGLFLFLAAVALLFLLFL 360
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
148-363 |
1.71e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.67 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 148 RSRVNALFMMGIPVAGVIGGPLSGWIMQAFNGVQGLANWQWLFLLEAipslILGVVTLMYLPNGIRAAKWLTDTEKQLLE 227
Cdd:cd17332 134 RTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIG----IIGIILLLICFFGTRERVVPPEEEKSKLP 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 228 DRIAqdgagklnakISRVLGNGRVWFMAAIYFCCMMGLYGVGFYLPTLIKAAGVKDALDIGMLTAIPyGCAIVAMLLIAR 307
Cdd:cd17332 210 LLKS----------LKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLIL-SGALLALLPWPP 278
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 576733085 308 SADRLRERRWHFAAAGLMASVGLLTATIFGSNVGLAMVALSLGTAGVLATMPVFWA 363
Cdd:cd17332 279 LKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWA 334
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
56-207 |
4.57e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.12 E-value: 4.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 56 LKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWAL--ISTGTLYATTPTAFYVLRFLLGVAEAGFF- 132
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALglLLLFFLGPGNLWLLLVLAALAGIGLGAILv 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 133 ------PGIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNGVQGLAN--------WQWLFLLEAIPSL 198
Cdd:COG2211 339 lpwamlADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQspsaltgiRLLFFLLPAVLLL 418
|
....*....
gi 576733085 199 ILGVVTLMY 207
Cdd:COG2211 419 LAALLLLFY 427
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
69-209 |
5.03e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.72 E-value: 5.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 69 IFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAGFFPGIVLYLTYWYPAERR 148
Cdd:cd17317 33 IFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYR 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 576733085 149 SRVNALFMMGIPVAGVIGGPLSGWImqafngvqglANWQWLFLLEAIPSLILgVVTLMYLP 209
Cdd:cd17317 113 SFVGILFGLFWALGYMLLALLAYLI----------RDWRWLQLAISLPGLLF-LLLLWWLP 162
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
70-352 |
8.40e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 38.19 E-value: 8.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 70 FFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYV--LRFLLGVAEAGFFPGIVLYLTYWYPAER 147
Cdd:TIGR00894 85 HFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVvfCRVIQGLAQGSVSPATHKIIVKWAPPKE 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 148 RSRVNALFMMGIPVAGVIGGPLSGWIMQAFNGvqglanWQWLFLLEAIPSLILGVVTLMYLPNGIRAAKWLTDTEKQLLE 227
Cdd:TIGR00894 165 RSRLLGMSTSGFQLGTFIFLPISGWLCESWGG------WPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYIN 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 228 DRI-AQDGAGKLNAKISRVLGNGRVWfmaAIYFCCMMGLYGVGF---YLPTLIKAAGVKDALDIGMLTAIPYGCAIVAML 303
Cdd:TIGR00894 239 SSLqGQKGSTRQSLPIKAIPKSLPVW---AIWFAIFGHFWLYTIlptYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSI 315
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 576733085 304 LIARSADRLRERRWH--FAAAGLMASVGLLTATIF-------GSNVGLAMVALSLGTA 352
Cdd:TIGR00894 316 FAGYLADFLKSSKTLslTAARKIFNGIGGLGPGIFayalpylSAAFYLTIIILTLANA 373
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
51-215 |
8.96e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 38.32 E-value: 8.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 51 QMLSDLKFSDTVYGLGAGIFFIGYIFFEVPSNVLMHRFGARVWISRIMITWALISTGTLYATTPTAFYVLRFLLGVAEAG 130
Cdd:COG2807 240 PILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGG 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576733085 131 FFP-GIVLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSGWIMQAFNGvqglanWQWLFLLEAIPSLILGVVTLMYLP 209
Cdd:COG2807 320 LFPlALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGS------WTAALLLLAALAVLMLVAGLLAGR 393
|
....*.
gi 576733085 210 NGIRAA 215
Cdd:COG2807 394 PYVEDA 399
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
60-205 |
9.83e-03 |
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Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.01 E-value: 9.83e-03
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gi 576733085 60 DTVYGLGAGIFFIGYIFFEVPSNVLMHRFGaRVWISRIMITWALISTGTLY----ATTPTAFYVLRFLLGVAEAGFFPGI 135
Cdd:cd17357 48 DLLWSLIVSIFFIGGAIGSFISAFLANRFG-RKNGLLISNALLVVSSLLMFlsksAKSPELLIFGRFLVGIACGLSTGFV 126
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gi 576733085 136 VLYLTYWYPAERRSRVNALFMMGIPVAGVIGGPLSgwiMQAFNGVQglANWQWLFLLEAIPSLILGVVTL 205
Cdd:cd17357 127 PMYLQEISPSELRGALGSLTQIGVTLGILLGQVFG---LPSVLGTE--TLWPYLLFFPGIPALLQLAALP 191
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