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Conserved domains on  [gi|2315513034|dbj|GIU70305|]
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MAG: galactosyl-transferase RfpB-like protein [Candidatus Woesearchaeota archaeon]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 2-361 6.04e-33

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03794:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 391  Bit Score: 126.69  E-value: 6.04e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034   2 NIVMYSaDYFPPKQMNAnHNRLHRLAKGLSKK-HNVVIFCPNKYYcYDESEFDGIKIIR----------IPNINIRFIKR 70
Cdd:cd03794     1 KILLIS-QYYPPPKGAA-AARVYELAKELVRRgHEVTVLTPSPNY-PLGRIFAGATETKdgirvirvklGPIKKNGLIRR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034  71 VFQSITAYIFIKKKLKN----------FSIDIFWYNSAhsFLLSKKFRCLKIFDVMGLiqLESTKKDNSIL-AKLKQTYY 139
Cdd:cd03794    78 LLNYLSFALAALLKLLVreerpdviiaYSPPITLGLAA--LLLKKLRGAPFILDVRDL--WPESLIALGVLkKGSLLKLL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 140 KKIENKVLQNSNYIITVNEAHKKTILKIIKKDI--FVLRDGFDKLFLKPYKK-------KEDNTIRITFVGSL-FKDRLN 209
Cdd:cd03794   154 KKLERKLYRLADAIIVLSPGLKEYLLRKGVPKEkiIVIPNWADLEEFKPPPKdelrkklGLDDKFVVVYAGNIgKAQGLE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 210 GIIEKFStIIKRNNNIYFEIIGDGTYIRKYKEIISKNNcKKNVKFSGYLENNIVYSHLKNSDICF----SDDWSYIGFPT 285
Cdd:cd03794   234 TLLEAAE-RLKRRPDIRFLFVGDGDEKERLKELAKARG-LDNVTFLGRVPKEEVPELLSAADVGLvplkDNPANRGSSPS 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2315513034 286 KVFEYMAMGKAVLVEDTPAVREIVKDGINGIL--YKDPDDFVDKLLMLAKNKKLRKKIGKNAKKDAK-NHTWDVRAKQF 361
Cdd:cd03794   312 KLFEYMAAGKPILASDDGGSDLAVEINGCGLVvePGDPEALADAILELLDDPELRRAMGENGRELAEeKFSREKLADRL 390
 
Name Accession Description Interval E-value
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 2-361 6.04e-33

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 126.69  E-value: 6.04e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034   2 NIVMYSaDYFPPKQMNAnHNRLHRLAKGLSKK-HNVVIFCPNKYYcYDESEFDGIKIIR----------IPNINIRFIKR 70
Cdd:cd03794     1 KILLIS-QYYPPPKGAA-AARVYELAKELVRRgHEVTVLTPSPNY-PLGRIFAGATETKdgirvirvklGPIKKNGLIRR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034  71 VFQSITAYIFIKKKLKN----------FSIDIFWYNSAhsFLLSKKFRCLKIFDVMGLiqLESTKKDNSIL-AKLKQTYY 139
Cdd:cd03794    78 LLNYLSFALAALLKLLVreerpdviiaYSPPITLGLAA--LLLKKLRGAPFILDVRDL--WPESLIALGVLkKGSLLKLL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 140 KKIENKVLQNSNYIITVNEAHKKTILKIIKKDI--FVLRDGFDKLFLKPYKK-------KEDNTIRITFVGSL-FKDRLN 209
Cdd:cd03794   154 KKLERKLYRLADAIIVLSPGLKEYLLRKGVPKEkiIVIPNWADLEEFKPPPKdelrkklGLDDKFVVVYAGNIgKAQGLE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 210 GIIEKFStIIKRNNNIYFEIIGDGTYIRKYKEIISKNNcKKNVKFSGYLENNIVYSHLKNSDICF----SDDWSYIGFPT 285
Cdd:cd03794   234 TLLEAAE-RLKRRPDIRFLFVGDGDEKERLKELAKARG-LDNVTFLGRVPKEEVPELLSAADVGLvplkDNPANRGSSPS 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2315513034 286 KVFEYMAMGKAVLVEDTPAVREIVKDGINGIL--YKDPDDFVDKLLMLAKNKKLRKKIGKNAKKDAK-NHTWDVRAKQF 361
Cdd:cd03794   312 KLFEYMAAGKPILASDDGGSDLAVEINGCGLVvePGDPEALADAILELLDDPELRRAMGENGRELAEeKFSREKLADRL 390
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 197-348 1.79e-26

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 103.51  E-value: 1.79e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 197 ITFVGSLFKD-RLNGIIEKFSTIIKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVKFSGYLENNIVYSHLKNSDI-CF 274
Cdd:pfam00534   5 ILFVGRLEPEkGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVfVL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2315513034 275 SDDWSyiGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYK--DPDDFVDKLLMLAKNKKLRKKIGKNAKKD 348
Cdd:pfam00534  85 PSRYE--GFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKpnNAEALAEAIDKLLEDEELRERLGENARKR 158
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 266-369 1.35e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 88.89  E-value: 1.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 266 HLKNSDICFSDDWsYIGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYK--DPDDFVDKLLMLAKNKKLRKKIGK 343
Cdd:COG0438    17 LLAAADVFVLPSR-SEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPpgDPEALAEAILRLLEDPELRRRLGE 95

                          90       100
                  ....*....|....*....|....*..
gi 2315513034 344 NAKKDA-KNHTWDVRAKQFNKIIKEIC 369
Cdd:COG0438    96 AARERAeERFSWEAIAERLLALYEELL 122
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
190-344 5.01e-06

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 47.78  E-value: 5.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 190 KEDNTIRITFVGSLFKDRLNGIIEKFSTIIKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVKFSGYLEN--NIVYSHL 267
Cdd:PRK09922  176 ERDKPAVFLYVGRLKFEGQKNVKELFDGLSQTTGEWQLHIIGDGSDFEKCKAYSRELGIEQRIIWHGWQSQpwEVVQQKI 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 268 KNSDICFSDDwSYIGFPTKVFEYMAMGKAVLVEDTP-AVREIVKDGINGILYK--DPDDFVDKL-LMLAKNKKLRKKIGK 343
Cdd:PRK09922  256 KNVSALLLTS-KFEGFPMTLLEAMSYGIPCISSDCMsGPRDIIKPGLNGELYTpgNIDEFVGKLnKVISGEVKYQHDAIP 334


                  .
gi 2315513034 344 N 344
Cdd:PRK09922  335 N 335
 
Name Accession Description Interval E-value
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 2-361 6.04e-33

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 126.69  E-value: 6.04e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034   2 NIVMYSaDYFPPKQMNAnHNRLHRLAKGLSKK-HNVVIFCPNKYYcYDESEFDGIKIIR----------IPNINIRFIKR 70
Cdd:cd03794     1 KILLIS-QYYPPPKGAA-AARVYELAKELVRRgHEVTVLTPSPNY-PLGRIFAGATETKdgirvirvklGPIKKNGLIRR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034  71 VFQSITAYIFIKKKLKN----------FSIDIFWYNSAhsFLLSKKFRCLKIFDVMGLiqLESTKKDNSIL-AKLKQTYY 139
Cdd:cd03794    78 LLNYLSFALAALLKLLVreerpdviiaYSPPITLGLAA--LLLKKLRGAPFILDVRDL--WPESLIALGVLkKGSLLKLL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 140 KKIENKVLQNSNYIITVNEAHKKTILKIIKKDI--FVLRDGFDKLFLKPYKK-------KEDNTIRITFVGSL-FKDRLN 209
Cdd:cd03794   154 KKLERKLYRLADAIIVLSPGLKEYLLRKGVPKEkiIVIPNWADLEEFKPPPKdelrkklGLDDKFVVVYAGNIgKAQGLE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 210 GIIEKFStIIKRNNNIYFEIIGDGTYIRKYKEIISKNNcKKNVKFSGYLENNIVYSHLKNSDICF----SDDWSYIGFPT 285
Cdd:cd03794   234 TLLEAAE-RLKRRPDIRFLFVGDGDEKERLKELAKARG-LDNVTFLGRVPKEEVPELLSAADVGLvplkDNPANRGSSPS 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2315513034 286 KVFEYMAMGKAVLVEDTPAVREIVKDGINGIL--YKDPDDFVDKLLMLAKNKKLRKKIGKNAKKDAK-NHTWDVRAKQF 361
Cdd:cd03794   312 KLFEYMAAGKPILASDDGGSDLAVEINGCGLVvePGDPEALADAILELLDDPELRRAMGENGRELAEeKFSREKLADRL 390
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 2-366 7.85e-33

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 126.11  E-value: 7.85e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034   2 NIVMYSADYFPPkqMNANHNRLHRLAKGLSKK-HNVVIFCPNKYYCYDESEFDGIKIIRIPNINirFIKRVFQSITAyif 80
Cdd:cd03801     1 KILLLSPELPPP--VGGAERHVRELARALAARgHDVTVLTPADPGEPPEELEDGVIVPLLPSLA--ALLRARRLLRE--- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034  81 IKKKLKNFSIDIFWYNSAHSFLLskkFRCLKIFDVMGLIQL--ESTKKDNSILAKLKQTYYKKIENkVLQNSNYIITVNE 158
Cdd:cd03801    74 LRPLLRLRKFDVVHAHGLLAALL---AALLALLLGAPLVVTlhGAEPGRLLLLLAAERRLLARAEA-LLRRADAVIAVSE 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 159 A---HKKTILKIIKKDIFVLRDGFD-KLFLKPYKKKE---DNTIRITFVGSLFK----DRLngiIEKFSTIIKRNNNIYF 227
Cdd:cd03801   150 AlrdELRALGGIPPEKIVVIPNGVDlERFSPPLRRKLgipPDRPVLLFVGRLSPrkgvDLL---LEALAKLLRRGPDVRL 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 228 EIIG-DGTYIRKYKEIisKNNCKKNVKFSGYLENNIVYSHLKNSDICF--SDdwsYIGFPTKVFEYMAMGKAVLVEDTPA 304
Cdd:cd03801   227 VIVGgDGPLRAELEEL--ELGLGDRVRFLGFVPDEELPALYAAADVFVlpSR---YEGFGLVVLEAMAAGLPVVATDVGG 301

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2315513034 305 VREIVKDGINGILY--KDPDDFVDKLLMLAKNKKLRKKIGKNAKKD-AKNHTWDVRAKQFNKIIK 366
Cdd:cd03801   302 LPEVVEDGEGGLVVppDDVEALADALLRLLADPELRARLGRAARERvAERFSWERVAERLLDLYR 366
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 197-348 1.79e-26

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 103.51  E-value: 1.79e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 197 ITFVGSLFKD-RLNGIIEKFSTIIKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVKFSGYLENNIVYSHLKNSDI-CF 274
Cdd:pfam00534   5 ILFVGRLEPEkGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVfVL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2315513034 275 SDDWSyiGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYK--DPDDFVDKLLMLAKNKKLRKKIGKNAKKD 348
Cdd:pfam00534  85 PSRYE--GFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKpnNAEALAEAIDKLLEDEELRERLGENARKR 158
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 26-352 1.24e-21

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 94.58  E-value: 1.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034  26 LAKGLSKK-HNVVIFCPnkYYCYDESEFDGIKIIRIPNINIRFIKRVFQSITAYIFIKKKLKNFSIDIFWYNSAHSFLLS 104
Cdd:cd03808    19 LIKALVKKgYEVHVIAP--DGDKLSDELKELGVKVIDIPILRRGINPLKDLKALFKLYKLLKKEKPDIVHCHTPKPGILG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 105 -----KKFRCLKIFDVMGLiqlESTKKDNSILAKLkqtyYKKIENKVLQNSNYIITVNEA--HKKTILKIIKKDIFVLRD 177
Cdd:cd03808    97 rlaarLAGVPKVIYTVHGL---GFVFTEGKLLRLL----YLLLEKLALLFTDKVIFVNEDdrDLAIKKGIIKKKKTVLIP 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 178 G--FDKLFLKP-YKKKEDNTIRITFVGSLFKD-RLNGIIEKFSTIIKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVK 253
Cdd:cd03808   170 GsgVDLDRFQYsPESLPSEKVVFLFVARLLKDkGIDELIEAAKILKKKGPNVRFLLVGDGELENPSEILIEKLGLEGRIE 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 254 FSGYLENniVYSHLKNSDIC--FSDdwsYIGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILY--KDPDDFVDKLL 329
Cdd:cd03808   250 FLGFRSD--VPELLAESDVFvlPSY---REGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLVppGDVEALADAIE 324

                         330       340
                  ....*....|....*....|...
gi 2315513034 330 MLAKNKKLRKKIGKNAKKDAKNH 352
Cdd:cd03808   325 KLIEDPELRKEMGEAARKRVEEK 347
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 266-369 1.35e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 88.89  E-value: 1.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 266 HLKNSDICFSDDWsYIGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYK--DPDDFVDKLLMLAKNKKLRKKIGK 343
Cdd:COG0438    17 LLAAADVFVLPSR-SEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPpgDPEALAEAILRLLEDPELRRRLGE 95

                          90       100
                  ....*....|....*....|....*..
gi 2315513034 344 NAKKDA-KNHTWDVRAKQFNKIIKEIC 369
Cdd:COG0438    96 AARERAeERFSWEAIAERLLALYEELL 122
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
196-334 5.13e-21

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 87.95  E-value: 5.13e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 196 RITFVGSLFK--DRLNGIIEKFSTIIKRNNNIYFEIIGDGTYiRKYKEIIskNNCKKNVKFSGYLENniVYSHLKNSDI- 272
Cdd:pfam13692   3 VILFVGRLHPnvKGVDYLLEAVPLLRKRDNDVRLVIVGDGPE-EELEELA--AGLEDRVIFTGFVED--LAELLAAADVf 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2315513034 273 CFSDDWSyiGFPTKVFEYMAMGKAVLVEDTPAVREIVkDGINGIL--YKDPDDFVDKLLMLAKN 334
Cdd:pfam13692  78 VLPSLYE--GFGLKLLEAMAAGLPVVATDVGGIPELV-DGENGLLvpPGDPEALAEAILRLLED 138
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 2-368 4.63e-20

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 90.42  E-value: 4.63e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034   2 NIVMYSADYFPpkQMNANHNRLHRLAKGLSKK-HNVVIFCPNkyycYDESEFD-GIKIIRIPNINIRFIKRVFQSITAYI 79
Cdd:cd03817     1 KIAIFTDTYLP--QVNGVATSVRNLARALEKRgHEVYVITPS----DPGAEDEeEVVRYRSFSIPIRKYHRQHIPFPFKK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034  80 FIKKKLKNFSIDIfwynsAHS---FLLSKKfrCLKIFDVMGL-------IQLESTKKDNSILAKLKQTYYKKIENKVLQN 149
Cdd:cd03817    75 AVIDRIKELGPDI-----IHThtpFSLGKL--GLRIARKLKIpivhtyhTMYEDYLHYIPKGKLLVKAVVRKLVRRFYNH 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 150 SNYIITVNEAHKKT-ILKIIKKDIFVLRDGFD-KLFLKPYKKKE-------DNTIRITFVGSLFKD-RLNGIIEKFsTII 219
Cdd:cd03817   148 TDAVIAPSEKIKDTlREYGVKGPIEVIPNGIDlDKFEKPLNTEErrklglpPDEPILLYVGRLAKEkNIDFLLRAF-AEL 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 220 KRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVKFSGYLENNIVYSHLKNSDI-CFSDDwsYIGFPTKVFEYMAMGKAVL 298
Cdd:cd03817   227 KKEPNIKLVIVGDGPEREELKELARELGLADKVIFTGFVPREELPEYYKAADLfVFAST--TETQGLVYLEAMAAGLPVV 304

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2315513034 299 VEDTPAVREIVKDGINGILYK-DPDDFVDKLLMLAKNKKLRKKIGKNAKKDAKNHTwdvRAKQFNKIIKEI 368
Cdd:cd03817   305 AAKDPAASELVEDGENGFLFEpNDETLAEKLLHLRENLELLRKLSKNAEISAREFA---FAKSVEKLYEEV 372
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 25-347 7.49e-20

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 89.34  E-value: 7.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034  25 RLAKGLSK-KHNVVIFCPNKYYCYDESEFDGIKIIRIPNINIRFIKRVFqsITAYIFIKKKLKNFSID-IFWYNSAHSFL 102
Cdd:cd03811    20 NLANALDKrGYDVTLVLLRDEGDLDKQLNGDVKLIRLLIRVLKLIKLGL--LKAILKLKRILKRAKPDvVISFLGFATYI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 103 LSKKF-RCLKIFDVMGLIQLESTKKDNSILAKLKqtYYKKienkvlqnSNYIITVNEA---HKKTILKIIKKDIFVLRDG 178
Cdd:cd03811    98 VAKLAaARSKVIAWIHSSLSKLYYLKKKLLLKLK--LYKK--------ADKIVCVSKGikeDLIRLGPSPPEKIEVIYNP 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 179 FD-----KLFLKPYKKKEDNTIRITFVGSLFKD-RLNGIIEKFSTIIKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNV 252
Cdd:cd03811   168 IDidrirALAKEPILNEPEDGPVILAVGRLDPQkGHDLLIEAFAKLRKKYPDVKLVILGDGPLREELEKLAKELGLAERV 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 253 KFSGYLENniVYSHLKNSD--ICFSDdwsYIGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYKDPD-DFVDKLL 329
Cdd:cd03811   248 IFLGFQSN--PYPYLKKADlfVLSSR---YEGFPNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVPDGDaAALAGIL 322

                         330
                  ....*....|....*...
gi 2315513034 330 MLAKNKKLRKKIGKNAKK 347
Cdd:cd03811   323 AALLQKKLDAALRERLAK 340
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
282-361 9.31e-17

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 74.56  E-value: 9.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 282 GFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYKDPDDFVDKLLMLAKNKKLRKKIGKNAKKDA-KNHTWDVRAKQ 360
Cdd:pfam13524  11 SPNMRVFEAAACGAPLLTDRTPGLEELFEPGEEILLYRDPEELAEKIRYLLEHPEERRAIAAAGRERVlAEHTYAHRAEQ 90


                  .
gi 2315513034 361 F 361
Cdd:pfam13524  91 L 91
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 26-360 3.54e-16

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 78.94  E-value: 3.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034  26 LAKGLSKKHNVVIFcpnKYYCYDESEFDGIKIIRIPNINIRFIKRVFQSITAYIFIKKKL-KNFSIDIFWynSAHSFLLS 104
Cdd:cd03809    23 LLKALAKNDPDESV---LAVPPLPGELLRLLREYPELSLGVIKIKLWRELALLRWLQILLpKKDKPDLLH--SPHNTAPL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 105 KKFRCLKIFDVMGLIQLESTKkdnsILAKLKQTYYKKIENKVLQNSNYIITVNEA---HKKTILKIIKKDIFVLRDGFDK 181
Cdd:cd03809    98 LLKGCPQVVTIHDLIPLRYPE----FFPKRFRLYYRLLLPISLRRADAIITVSEAtrdDIIKFYGVPPEKIVVIPLGVDP 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 182 LFLKPYKKKEDNTIR------ITFVGSL--FKDrLNGIIEKFSTIIKRNNNIYFEIIG-DGTYIRKYKEIISKNNCKKNV 252
Cdd:cd03809   174 SFFPPESAAVLIAKYllpepyFLYVGTLepRKN-HERLLKAFALLKKQGGDLKLVIVGgKGWEDEELLDLVKKLGLGGRV 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 253 KFSGYLENNIVYSHLKNSDI-CF-SddwSYIGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYKDPDDFVDKLLM 330
Cdd:cd03809   253 RFLGYVSDEDLPALYRGARAfVFpS---LYEGFGLPVLEAMACGTPVIASNISVLPEVAGDAALYFDPLDPESIADAILR 329

                         330       340       350
                  ....*....|....*....|....*....|
gi 2315513034 331 LAKNKKLRKKIGKNAKKDAKNHTWDVRAKQ 360
Cdd:cd03809   330 LLEDPSLREELIRKGLERAKKFSWEKTAEK 359
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 196-363 2.06e-15

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 76.51  E-value: 2.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 196 RITFVGSLFK----DRLngiIEKFSTIIKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVKFSGYLENniVYSHLKNSD 271
Cdd:cd03820   183 RILAVGRLTYqkgfDLL---IEAWALIAKKHPDWKLRIYGDGPEREELEKLIDKLGLEDRVKLLGPTKN--IAEEYANSS 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 272 I-CFSDDWSyiGFPTKVFEYMAMGKAVLVED-TPAVREIVKDGINGIL--YKDPDDFVDKLLMLAKNKKLRKKIGKNAKK 347
Cdd:cd03820   258 IfVLSSRYE--GFPMVLLEAMAYGLPIISFDcPTGPSEIIEDGENGLLvpNGDVDALAEALLRLMEDEELRKKMGKNARK 335

                         170
                  ....*....|....*.
gi 2315513034 348 DAKNHTWDVRAKQFNK 363
Cdd:cd03820   336 NAERFSIEKIIKQWEE 351
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 132-355 1.81e-12

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 67.71  E-value: 1.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 132 AKLKQTYYKKIENkvLQNSNYIITVNEA--HKKTILKIIKKDIFVLRDGFDKLFLKPYKKKEDNTIRITFVGSLFKD-RL 208
Cdd:cd04949    98 SLIKNFYKYVFEN--LNKYDAIIVSTEQqkQDLSERFNKYPPIFTIPVGYVDQLDTAESNHERKSNKIITISRLAPEkQL 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 209 NGIIEKFSTIIKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVKFSGYlennivyshLKNSDICFSDDWSYI------G 282
Cdd:cd04949   176 DHLIEAVAKAVKKVPEITLDIYGYGEEREKLKKLIEELHLEDNVFLKGY---------HSNLDQEYQDAYLSLltsqmeG 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 283 FPTKVFEYMAMGKAVLVEDTP-AVREIVKDGINGIL--YKDPDDFVDKLLMLAKNKKLRKKIG----KNAKKDAKNHTWD 355
Cdd:cd04949   247 FGLTLMEAIGHGLPVVSYDVKyGPSELIEDGENGYLieKNNIDALADKIIELLNDPEKLQQFSeesyKIAEKYSTENVME 326
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 174-352 5.12e-11

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 63.49  E-value: 5.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 174 VLRDGFDKLFLKPYKKK----------EDNTIRITFVGSLFKD-RLNGIIEKFSTIIKRNNNIYFEIIGDGTyIRKYKEI 242
Cdd:cd03807   160 VIYNGIDLFKLSPDDASrararrrlglAEDRRVIGIVGRLHPVkDHSDLLRAAALLVETHPDLRLLLVGRGP-ERPNLER 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 243 ISKNNC-KKNVKFSGYLENniVYSHLKNSDI-CFSDDwsYIGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGiNGILY-- 318
Cdd:cd03807   239 LLLELGlEDRVHLLGERSD--VPALLPAMDIfVLSSR--TEGFPNALLEAMACGLPVVATDVGGAAELVDDG-TGFLVpa 313

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2315513034 319 KDPDDFVDKLLMLAKNKKLRKKIGKNAKKDAKNH 352
Cdd:cd03807   314 GDPQALADAIRALLEDPEKRARLGRAARERIANE 347
COG4641 COG4641
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
178-368 5.26e-11

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 63.03  E-value: 5.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 178 GFDKLFLKPYKKKEDNTIRITFVGSLFKDRlngiIEKFSTIIKRNNNIYFEIIGDGtYIRKYKEiisknnckKNVKFSGY 257
Cdd:COG4641   121 AADPELHRPVPPEARFRYDVAFVGNYYPDR----RARLEELLLAPAGLRLKIYGPG-WPKLALP--------ANVRRGGH 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 258 LENNIVYSHLKNSDIC---FSDDWSYIGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYKDPDDFVDKLLMLAKN 334
Cdd:COG4641   188 LPGEEHPAAYASSKITlnvNRMAASPDSPTRRTFEAAACGAFLLSDPWEGLEELFEPGEEVLVFRDGEELAEKLRYLLAD 267

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2315513034 335 KKLRKKIGKNA-KKDAKNHTWDVRAKQFNKIIKEI 368
Cdd:COG4641   268 PEERRAIAEAGrRRVLAEHTYAHRARELLAILEEL 302
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 173-322 6.51e-10

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 60.09  E-value: 6.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 173 FVLRDGFDKLFLKP---YKKKEDNTIRITFVGSLFKD-RLNGIIEKFSTIIKRNNNIYFEIIGDGTYIRKYKEIISKNNC 248
Cdd:cd03798   176 DVIPNGVDPARFQPedrGLGLPLDAFVILFVGRLIPRkGIDLLLEAFARLAKARPDVVLLIVGDGPLREALRALAEDLGL 255

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2315513034 249 KKNVKFSGYLENNIVYSHLKNSDI-CFSddwSYI-GFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYKDPD 322
Cdd:cd03798   256 GDRVTFTGRLPHEQVPAYYRACDVfVLP---SRHeGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETGLLVPPGD 328
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 71-318 2.68e-09

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 57.03  E-value: 2.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034  71 VFQSITAYIFIKKKLKNFSIDIFWYNSAHSFLLSKKFRCLKifdvmgliqlestkKDNSILAklkqtyykkienkvlqns 150
Cdd:cd01635    36 LALLLLALRRILKKLLELKPDVVHAHSPHAAALAALLAARL--------------LGIPIVV------------------ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 151 nYIITVNEAHKKTILKIIKKDIFVLRDGFDKLFlkpykkkedntiritfVGSLFKDRLNGI-IEKFSTIIKRNNNIYFEI 229
Cdd:cd01635    84 -TVHGPDSLESTRSELLALARLLVSLPLADKVS----------------VGRLVPEKGIDLlLEALALLKARLPDLVLVL 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 230 IGDGTYIRKYKEIISKNNCKKNVKF-SGYLENNIVYSHLKNSDICFSDDWsYIGFPTKVFEYMAMGKAVLVEDTPAVREI 308
Cdd:cd01635   147 VGGGGEREEEEALAAALGLLERVVIiGGLVDDEVLELLLAAADVFVLPSR-SEGFGLVLLEAMAAGKPVIATDVGGIPEF 225

                         250
                  ....*....|
gi 2315513034 309 VKDGINGILY 318
Cdd:cd01635   226 VVDGENGLLV 235
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 174-352 3.33e-09

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 57.85  E-value: 3.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 174 VLRDGFD--KLFLKPYKKKEDNTIRITFVGSLF-KDRLNGIIEKFSTIIKRNNNIYFEIIGDGTYIRKYKEIISKNNCKK 250
Cdd:cd03799   152 VHRSGIDcnKFRFKPRYLPLDGKIRILTVGRLTeKKGLEYAIEAVAKLAQKYPNIEYQIIGDGDLKEQLQQLIQELNIGD 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 251 NVKFSGYLENNIVYSHLKNSDICF-----SDDWSYIGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILY--KDPDD 323
Cdd:cd03799   232 CVKLLGWKPQEEIIEILDEADIFIapsvtAADGDQDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVpeRDAEA 311

                         170       180
                  ....*....|....*....|....*....
gi 2315513034 324 FVDKLLMLAKNKKLRKKIGKNAKKDAKNH 352
Cdd:cd03799   312 IAEKLTYLIEHPAIWPEMGKAGRARVEEE 340
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 278-346 5.56e-09

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 57.37  E-value: 5.56e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2315513034 278 WSyigfptkVFEYMAMGKAVLVEDTPAVREIVKDGINGIL--YKDPDDFVDKLLMLAKNKKLRKKIGKNAK 346
Cdd:cd03818   315 WS-------LLEAMACGCPVIGSDTAPVREVIRDGRNGLLvdFFDPDALAAAVLELLEDPDRAAALRRAAR 378
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 188-351 3.33e-07

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 51.69  E-value: 3.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 188 KKKEDNTIRITFVGSLFK-DRLNGIIEKFSTI--IKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVKFSGYLENNIVY 264
Cdd:cd04946   218 KVKKEGDLRLVSCSSIVPvKRIDLIIETLNSLcvAHPSICISWTHIGGGPLKERLEKLAENKLENVKVNFTGEVSNKEVK 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 265 SHLKNSDICFSDDWSYI-GFPTKVFEYMAMGKAVLVEDTPAVREIVKDGING-ILYKD--PDDFVDKLLMLAKNKKLRKK 340
Cdd:cd04946   298 QLYKENDVDVFVNVSESeGIPVSIMEAISFGIPVIATNVGGTREIVENETNGlLLDKDptPNEIVSSIMKFYLDGGDYKT 377

                         170
                  ....*....|.
gi 2315513034 341 IGKNAKKDAKN 351
Cdd:cd04946   378 MKISARECWEE 388
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 188-350 3.72e-07

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 51.95  E-value: 3.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 188 KKKEDNTIRITFVGSL--FKDrLNGIIEKFSTIIKRNNNIYFEIIG----DGTYIRKYKEIISKNNCKKNVKFSGYLENN 261
Cdd:cd03813   287 ERPEKEPPVVGLVGRVvpIKD-VKTFIRAFKLVRRAMPDAEGWLIGpedeDPEYAQECKRLVASLGLENKVKFLGFQNIK 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 262 IVYSHLknsDICFSDDWSYiGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILY-------KDPDDFVDKLLMLAKN 334
Cdd:cd03813   366 EYYPKL---GLLVLTSISE-GQPLVILEAMASGVPVVATDVGSCRELIYGADDALGQaglvvppADPEALAEALIKLLRD 441

                         170
                  ....*....|....*.
gi 2315513034 335 KKLRKKIGKNAKKDAK 350
Cdd:cd03813   442 PELRQAFGEAGRKRVE 457
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 221-347 5.10e-07

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 51.12  E-value: 5.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 221 RNNNIYFEIIGDGTYIRKYKEIISKNNcKKNVKFSGYLENNIVYSHLKNSDI-CFSDDWSYIGFPTKVFEYMAMGKAVLV 299
Cdd:cd03795   214 QYLNYPIVIGGEGPLKPDLEAQIELNL-LDNVKFLGRVDDEEKVIYLHLCDVfVFPSVLRSEAFGIVLLEAMMCGKPVIS 292

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2315513034 300 EDTP-AVREIVKDGINGILY--KDPDDFVDKLLMLAKNKKLRKKIGKNAKK 347
Cdd:cd03795   293 TNIGtGVPYVNNNGETGLVVppKDPDALAEAIDKLLSDEELRESYGENAKK 343
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 183-366 2.92e-06

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 48.92  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 183 FLKPYKKKEDntiritfvgslfkdrlngIIEKFSTIIKRNNNIYFEIIG-------DGTYIRKYKEIISKNNCKKNVKF- 254
Cdd:cd03822   195 FIGPGKGLEI------------------LLEALPELKAEFPDVRLVIAGelhpslaRYEGERYRKAAIEELGLQDHVDFh 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 255 SGYLENNIVYSHLKNSDIcfsddwsYIgFP--------TKVFEY-MAMGKAVLVEDTPAVREIVKDGiNGILYK--DPDD 323
Cdd:cd03822   257 NNFLPEEEVPRYISAADV-------VV-LPylnteqssSGTLSYaIACGKPVISTPLRHAEELLADG-RGVLVPfdDPSA 327

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2315513034 324 FVDKLLMLAKNKKLRKKIGKNAKKDAKNHTWDVRAKQFNKIIK 366
Cdd:cd03822   328 IAEAILRLLEDDERRQAIAERAYAYARAMTWESIADRYLRLFN 370
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
190-344 5.01e-06

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 47.78  E-value: 5.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 190 KEDNTIRITFVGSLFKDRLNGIIEKFSTIIKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVKFSGYLEN--NIVYSHL 267
Cdd:PRK09922  176 ERDKPAVFLYVGRLKFEGQKNVKELFDGLSQTTGEWQLHIIGDGSDFEKCKAYSRELGIEQRIIWHGWQSQpwEVVQQKI 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 268 KNSDICFSDDwSYIGFPTKVFEYMAMGKAVLVEDTP-AVREIVKDGINGILYK--DPDDFVDKL-LMLAKNKKLRKKIGK 343
Cdd:PRK09922  256 KNVSALLLTS-KFEGFPMTLLEAMSYGIPCISSDCMsGPRDIIKPGLNGELYTpgNIDEFVGKLnKVISGEVKYQHDAIP 334


                  .
gi 2315513034 344 N 344
Cdd:PRK09922  335 N 335
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 218-345 5.86e-06

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 47.73  E-value: 5.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 218 IIKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVKFSGYLENniVYSHLKNSDICFSDDwSYIGFPTKVFEYMAMGKAV 297
Cdd:cd03819   206 ELKDEPDFRLLVAGDGPERDEIRRLVERLGLRDRVTFTGFRED--VPAALAASDVVVLPS-LHEEFGRVALEAMACGTPV 282

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2315513034 298 LVEDTPAVREIVKDGINGILYKDPDD--FVDKLLMLAKNKKLRKKIGKNA 345
Cdd:cd03819   283 VATDVGGAREIVVHGRTGLLVPPGDAeaLADAIRAAKLLPEAREKLQAAA 332
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 283-368 7.67e-06

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 47.33  E-value: 7.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 283 FPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYK--DPDDFVDKLLMLAKNKKLRKKIGKNAKKDAKNH-TWDVRAK 359
Cdd:cd03825   276 LPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLVPpgDVQALAEAIEWLLANPKERESLGERARALAENHfDQRVQAQ 355


                  ....*....
gi 2315513034 360 QFNKIIKEI 368
Cdd:cd03825   356 RYLELYKDL 364
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 196-362 1.09e-05

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 46.98  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 196 RITFVGSL-FKDRLNGIIEKFSTIIKRNNNIYFEIIG-DGTYIRKYKEIISKNNCKKNVKFSGYLENNIVYSHLKNSDI- 272
Cdd:cd03821   206 IILFLGRIhPKKGLDLLIRAARKLAEQGRDWHLVIAGpDDGAYPAFLQLQSSLGLGDRVTFTGPLYGEAKWALYASADLf 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 273 CFSddwSYI-GFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYKDPDDFVDKLLMLAKNKKLRKKIGKNAKKDA-- 349
Cdd:cd03821   286 VLP---SYSeNFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDPNVSSLAEALAEALRDPADRKRLGEMARRARqv 362

                         170
                  ....*....|....
gi 2315513034 350 -KNHTWDVRAKQFN 362
Cdd:cd03821   363 eENFSWEAVAGQLG 376
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 282-352 2.86e-05

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 45.77  E-value: 2.86e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2315513034 282 GFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYKDPDDFVDKLLMLAKNKKLRKKIGKNAKKDAKNH 352
Cdd:cd03792   291 GFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGAAVRILRLLTDPELRRKMGLAAREHVRDN 361
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 207-322 3.96e-05

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 44.97  E-value: 3.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 207 RLNGIIEKFSTIIKRnnniyFEIIGDGTYIRKYKEIISKNnckknVKFSGYLENNIVYSHLKNSDicfsddwSYIgFPTK 286
Cdd:cd03804   213 RIDLAVEAFNELPKR-----LVVIGDGPDLDRLRAMASPN-----VEFLGYQPDEVLKELLSKAR-------AFV-FAAE 274

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2315513034 287 ------VFEYMAMGKAVLVEDTPAVREIVKDGINGILYKDPD 322
Cdd:cd03804   275 edfgivPVEAQACGTPVIAFGKGGALETVRPGPTGILFGEQT 316
GT4_TuaH-like cd04950
teichuronic acid biosynthesis glycosyltransferase TuaH and similar proteins; Members of this ...
 283-367 6.14e-05

teichuronic acid biosynthesis glycosyltransferase TuaH and similar proteins; Members of this family may function in teichuronic acid biosynthesis/cell wall biogenesis. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340856 [Multi-domain]  Cd Length: 373  Bit Score: 44.67  E-value: 6.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 283 FPTKVFEYMAMGKAVLvedTPAVREIVK-DGINGILYKDPDDFV---DKLLMLAKNKKLRKKigknAKKDAKNHTWDVRA 358
Cdd:cd04950   290 SPLKLFEYLAAGKPVV---ATSIPSVVRfYGEAVLCGDDPDEFSaaiEKALALKGDARDKRL----ARALARQESWDERA 362


                  ....*....
gi 2315513034 359 KQFNKIIKE 367
Cdd:cd04950   363 RAMEEALQE 371
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 289-355 1.41e-04

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 43.38  E-value: 1.41e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 289 EYMAMGKAVLVEDTPAVREIVKDGINGILY--KDPDDFVDKLLMLAKNKKLRKKIGKNAKKDAKNH-TWD 355
Cdd:cd03800   321 EAMACGTPVVATAVGGLQDIVRDGRTGLLVdpHDPEALAAALRRLLDDPALWQRLSRAGLERARAHyTWE 390
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 218-366 2.47e-04

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 42.78  E-value: 2.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 218 IIKRNNNIYFEIIGDGTYIRKYKEIISKnnckKNVKFSGYLENNIVYSHLKNSDI-CFSDDWSYIGFptKVFEYMAMGKA 296
Cdd:PLN02871  284 VMERLPGARLAFVGDGPYREELEKMFAG----TPTVFTGMLQGDELSQAYASGDVfVMPSESETLGF--VVLEAMASGVP 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 297 VLVEDTPAVREIV---KDGINGILYK--DPDDFVDKLLMLAKNKKLRKKIGKNAKKDAKNHTWD-----VRAKQFNKIIK 366
Cdd:PLN02871  358 VVAARAGGIPDIIppdQEGKTGFLYTpgDVDDCVEKLETLLADPELRERMGAAAREEVEKWDWRaatrkLRNEQYSAAIW 437
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
21-159 3.25e-04

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 40.98  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034  21 NRLHRLAKGLSKK-HNVVIFCPNKyycYDESEFDGIKIIRIPNINIRFIKRVFQSITAYIFIKKKLKNFSIDIFWYNSAH 99
Cdd:pfam13439   5 RYVLELARALARRgHEVTVVTPGG---PGPLAEEVVRVVRVPRVPLPLPPRLLRSLAFLRRLRRLLRRERPDVVHAHSPF 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2315513034 100 SFLLSkKFRCLKIFDVmGLIQ----LESTKKDNSILAKLKQTYYKKIENKVLQNSNYIITVNEA 159
Cdd:pfam13439  82 PLGLA-ALAARLRLGI-PLVVtyhgLFPDYKRLGARLSPLRRLLRRLERRLLRRADRVIAVSEA 143
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 191-364 3.98e-04

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 42.05  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 191 EDNTIRITFVGSLF--KDRLNgIIEKFSTIIKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVKFSGYLENnivYSHLK 268
Cdd:cd04951   185 KNDEFVILNVGRLTeaKDYPN-LLLAISELILSKNDFKLLIAGDGPLRNELERLICNLNLVDRVILLGQISN---ISEYY 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 269 NSDICFSDDWSYIGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYKDPDDFVDKLL-MLAKNKKLRKKIGKNAKK 347
Cdd:cd04951   261 NAADLFVLSSEWEGFGLVVAEAMACERPVVATDAGGVAEVVGDHNYVVPVSDPQLLAEKIKeIFDMSDEERDILGNKNEY 340

                         170
                  ....*....|....*..
gi 2315513034 348 DAKNHTWDVRAKQFNKI 364
Cdd:cd04951   341 IAKNFSINTIVNEWERL 357
GT33_ALG1-like cd03816
chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is ...
 284-355 4.38e-04

chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is most closely related to the GT33 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.


Pssm-ID: 340843 [Multi-domain]  Cd Length: 411  Bit Score: 41.87  E-value: 4.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2315513034 284 PTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYKDPDDFVDKLLMLAKNKK--LRKKIGKNAKKDAKNhTWD 355
Cdd:cd03816   328 PMKVVDMFGCGLPVCAMDFKCIGELVKHGVNGLVFGDSEELAEQLIDLLSDFDrgKLNVLKKGAQEESEN-RWD 400
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 207-352 7.09e-04

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 41.18  E-value: 7.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 207 RLNGIIEKFSTIiKRNNNIYFEIIGDGTYIRKYKEIISKNNCKKNVKFSGYLENniVYSHLKNSDiCFSDDWSYIGFPTK 286
Cdd:cd04962   210 RIDDVVRVFARV-RRKIPAKLLLVGDGPERVPAEELARELGVEDRVLFLGKQDD--VEELLSIAD-LFLLPSEKESFGLA 285

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2315513034 287 VFEYMAMGKAVLVEDTPAVREIVKDGINGILYK--DPDDFVDKLLMLAKNKKLRKKIGKNAKKDAKNH 352
Cdd:cd04962   286 ALEAMACGVPVVSSNAGGIPEVVKHGETGFLSDvgDVDAMAKSALSILEDDELYNRMGRAARKRAAER 353
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 185-331 3.64e-03

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 38.85  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315513034 185 KPYKKKEDNTIRITFVGSL--FKdrlnGI---IEKFSTIikRNNNIYFEIIGDGTyirkyKEIISKNNCKKNVKFSGYLE 259
Cdd:cd03823   182 PPRRRPGTERLRFGYIGRLteEK----GIdllVEAFKRL--PREDIELVIAGHGP-----LSDERQIEGGRRIAFLGRVP 250

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2315513034 260 NNIVYSHLKNSDIC-FSDDWsYIGFPTKVFEYMAMGKAVLVEDTPAVREIVKDGINGILYK--DPDDFVDKLLML 331
Cdd:cd03823   251 TDDIKDFYEKIDVLvVPSIW-PEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVNGLLFApgDAEDLAAAMRRL 324
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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