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Conserved domains on  [gi|1886485994|gb|KAF6311505|]
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zinc finger protein 502 [Myotis myotis]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
39-442 1.97e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 1.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994  39 HTNEISNQSKCSTLSIRKKSWKCNKCGKTFTQSSSLTQHQITHTGERPYVC--EECGKAFSCSSFLVQHQRIHTEVKPYR 116
Cdd:COG5048    14 SVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 117 CEQCGKTfrCRSFLTQHQRIHTGEKPYKCN-----ECGNSFRSHSHLTEHQRIHTGEKPYK-CNRCGKAFNQNTHLIH-- 188
Cdd:COG5048    94 NSKSLPL--SNSKASSSSLSSSSSNSNDNNllsshSLPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPpl 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 189 -----------------HQRIHTGEKPYSCNECGSSFRKHSNLIQHQRIHTGEKPHKCDDCGKTFQTKANLSQHQRIHTG 251
Cdd:COG5048   172 panslskdpssnlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 252 EKPYKCKEC-----GKAFCQSPSLIKHL-RIHTG-EKPYKCKECGKAFTQSTPLTKHQR--IHTGE--RPYKCSE--CGK 318
Cdd:COG5048   252 DSSSSASESprsslPTASSQSSSPNESDsSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 319 AFIQSICLIRHQRSHTGEKPYKC--NECGKGFNQ--NTCLTQHMRIHTGEKPYKCKE-----CGKAFAHSSSLTEHHRTH 389
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllNNEPPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITH 411

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1886485994 390 T--GEKLFKCSECEKTFRKYAHLSEHYRIHTGEKPYECIECGKFFRHSSVLFRHQ 442
Cdd:COG5048   412 LsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
39-442 1.97e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 1.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994  39 HTNEISNQSKCSTLSIRKKSWKCNKCGKTFTQSSSLTQHQITHTGERPYVC--EECGKAFSCSSFLVQHQRIHTEVKPYR 116
Cdd:COG5048    14 SVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 117 CEQCGKTfrCRSFLTQHQRIHTGEKPYKCN-----ECGNSFRSHSHLTEHQRIHTGEKPYK-CNRCGKAFNQNTHLIH-- 188
Cdd:COG5048    94 NSKSLPL--SNSKASSSSLSSSSSNSNDNNllsshSLPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPpl 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 189 -----------------HQRIHTGEKPYSCNECGSSFRKHSNLIQHQRIHTGEKPHKCDDCGKTFQTKANLSQHQRIHTG 251
Cdd:COG5048   172 panslskdpssnlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 252 EKPYKCKEC-----GKAFCQSPSLIKHL-RIHTG-EKPYKCKECGKAFTQSTPLTKHQR--IHTGE--RPYKCSE--CGK 318
Cdd:COG5048   252 DSSSSASESprsslPTASSQSSSPNESDsSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 319 AFIQSICLIRHQRSHTGEKPYKC--NECGKGFNQ--NTCLTQHMRIHTGEKPYKCKE-----CGKAFAHSSSLTEHHRTH 389
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllNNEPPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITH 411

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1886485994 390 T--GEKLFKCSECEKTFRKYAHLSEHYRIHTGEKPYECIECGKFFRHSSVLFRHQ 442
Cdd:COG5048   412 LsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-378 2.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.40e-04
                          10        20
                  ....*....|....*....|....*
gi 1886485994 354 LTQHMRIHTGEKPYKCKECGKAFAH 378
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 197-249 6.01e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 6.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1886485994 197 KPYsCNECGSSFRKHSNLIQHQRIHtgekpH-KCDDCGKTFQTKANLSQH-QRIH 249
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAK-----HfKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
39-442 1.97e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 1.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994  39 HTNEISNQSKCSTLSIRKKSWKCNKCGKTFTQSSSLTQHQITHTGERPYVC--EECGKAFSCSSFLVQHQRIHTEVKPYR 116
Cdd:COG5048    14 SVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 117 CEQCGKTfrCRSFLTQHQRIHTGEKPYKCN-----ECGNSFRSHSHLTEHQRIHTGEKPYK-CNRCGKAFNQNTHLIH-- 188
Cdd:COG5048    94 NSKSLPL--SNSKASSSSLSSSSSNSNDNNllsshSLPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPpl 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 189 -----------------HQRIHTGEKPYSCNECGSSFRKHSNLIQHQRIHTGEKPHKCDDCGKTFQTKANLSQHQRIHTG 251
Cdd:COG5048   172 panslskdpssnlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 252 EKPYKCKEC-----GKAFCQSPSLIKHL-RIHTG-EKPYKCKECGKAFTQSTPLTKHQR--IHTGE--RPYKCSE--CGK 318
Cdd:COG5048   252 DSSSSASESprsslPTASSQSSSPNESDsSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 319 AFIQSICLIRHQRSHTGEKPYKC--NECGKGFNQ--NTCLTQHMRIHTGEKPYKCKE-----CGKAFAHSSSLTEHHRTH 389
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllNNEPPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITH 411

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1886485994 390 T--GEKLFKCSECEKTFRKYAHLSEHYRIHTGEKPYECIECGKFFRHSSVLFRHQ 442
Cdd:COG5048   412 LsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
141-446 6.79e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 6.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 141 KPYKCNECGNSFRSHSHLTEHQRIHTGEKPYKCNR--CGKAFNQNTHLIHHQRIHTGEKP-------------------- 198
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSdlnskslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 199 ----------------------------------YSCNECGSSFRKHSNLIQ-------------------------HQR 219
Cdd:COG5048   112 ssssnsndnnllsshslppssrdpqlpdllsisnLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlslliSSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 220 IHTGEKPHKCDDCGKTFQTKANLSQHQRIHTGEKPYKCKECGKAFCQSPSLIKHLRIHTGEKPYKCKECGKAFTQSTPLT 299
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 300 KHQRIHTGER-------PYKCSECGKAFIQSICLIRHQRS--HTGE--KPYKCNE--CGKGFNQNTCLTQHMRIHTGEKP 366
Cdd:COG5048   272 SSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 367 YKCKECGKAFAHSSSLTE-------HHRTHTGEKLFKC--SECEKTFRKYAHLSEHYRIHTGEKPYEC--IECGKFFRHS 435
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRH 431

                         410
                  ....*....|.
gi 1886485994 436 SVLFRHQKLHS 446
Cdd:COG5048   432 YNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-447 3.05e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 169 KPYKCNRCGKAFNQNTHLIHHQRIHTGEKPYSCN--ECGSSFRKHSNLIQHQRIHTGEKPHKCDDCGKTFQTKANLSQHQ 246
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 247 RIHTGE-KPYKCKECGKAFCQSPSLIKHLRIHTGEKPYKCKECGKAFTQS-----------------------TPLTKHQ 302
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnlSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 303 RIHTGERPYKCSECGKAFIQSIcLIRHQRSHTGEKPYKCNECGKGFNQNTCLTQHMRIHTGEKPYKCKEC-----GKAFA 377
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPS-SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESprsslPTASS 270

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1886485994 378 HSSSLTEHH-RTHTGEKL-FKCSECEKTFRKYAHLSEHYR--IHTGE--KPYEC--IECGKFFRHSSVLFRHQKLHSG 447
Cdd:COG5048   271 QSSSPNESDsSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-378 2.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.40e-04
                          10        20
                  ....*....|....*....|....*
gi 1886485994 354 LTQHMRIHTGEKPYKCKECGKAFAH 378
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-264 7.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.73e-04
                          10        20
                  ....*....|....*....|....
gi 1886485994 241 NLSQHQRIHTGEKPYKCKECGKAF 264
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-294 1.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 1886485994 269 SLIKHLRIHTGEKPYKCKECGKAFTQ 294
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-350 2.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|....*
gi 1886485994 326 LIRHQRSHTGEKPYKCNECGKGFNQ 350
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
213-236 3.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....
gi 1886485994 213 NLIQHQRIHTGEKPHKCDDCGKTF 236
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
157-182 4.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.18e-03
                          10        20
                  ....*....|....*....|....*.
gi 1886485994 157 HLTEHQRIHTGEKPYKCNRCGKAFNQ 182
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 279-357 4.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 4.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 279 GEKPYKCK--ECGKAFTQSTPLtKHQRIHtgerpykcSECGKAFIQSICLIRHQRSHTGEKPYKCNECGKGFNQNTCLTQ 356
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1886485994 357 H 357
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-322 4.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.66e-03
                          10        20
                  ....*....|....*....|....*
gi 1886485994 298 LTKHQRIHTGERPYKCSECGKAFIQ 322
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-434 5.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.67e-03
                          10        20
                  ....*....|....*....|....*.
gi 1886485994 409 HLSEHYRIHTGEKPYECIECGKFFRH 434
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 197-249 6.01e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 6.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1886485994 197 KPYsCNECGSSFRKHSNLIQHQRIHtgekpH-KCDDCGKTFQTKANLSQH-QRIH 249
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAK-----HfKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
130-154 7.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.11e-03
                          10        20
                  ....*....|....*....|....*
gi 1886485994 130 LTQHQRIHTGEKPYKCNECGNSFRS 154
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 223-306 7.30e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 7.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886485994 223 GEKPHKCD--DCGKTFQTKANLSQHqRIHtgekpykcKECGKAFCQSPSLIKHLRIHTGEKPYKCKECGKAFTQSTPLtK 300
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                  ....*.
gi 1886485994 301 HQRIHT 306
Cdd:COG5189   416 YHRKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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