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Conserved domains on  [gi|1886500574|gb|KAF6326072|]
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zinc finger protein 408 [Myotis myotis]

Protein Classification

SET domain-containing protein( domain architecture ID 1562517)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 52-170 1.06e-46

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd10520:

Pssm-ID: 394802  Cd Length: 121  Bit Score: 148.72  E-value: 1.06e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886500574  52 ALKTLPQGLALGPSLVEKQRLGVWCVGKPLQPGLLWGPLGEEAASEQKDEGVQPRQEEDvslGLWGDVCACERSSGWTSL 131
Cdd:cd10520     1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEES---GQSGDVLACEQSSKWMRF 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1886500574 132 VQRGRLEGEGNVAPVWISERLHLQVYRVVLPGFELLLWP 170
Cdd:cd10520    78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWP 116
 
Name Accession Description Interval E-value
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 52-170 1.06e-46

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 148.72  E-value: 1.06e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886500574  52 ALKTLPQGLALGPSLVEKQRLGVWCVGKPLQPGLLWGPLGEEAASEQKDEGVQPRQEEDvslGLWGDVCACERSSGWTSL 131
Cdd:cd10520     1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEES---GQSGDVLACEQSSKWMRF 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1886500574 132 VQRGRLEGEGNVAPVWISERLHLQVYRVVLPGFELLLWP 170
Cdd:cd10520    78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWP 116
 
Name Accession Description Interval E-value
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 52-170 1.06e-46

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 148.72  E-value: 1.06e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886500574  52 ALKTLPQGLALGPSLVEKQRLGVWCVGKPLQPGLLWGPLGEEAASEQKDEGVQPRQEEDvslGLWGDVCACERSSGWTSL 131
Cdd:cd10520     1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEES---GQSGDVLACEQSSKWMRF 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1886500574 132 VQRGRLEGEGNVAPVWISERLHLQVYRVVLPGFELLLWP 170
Cdd:cd10520    78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWP 116
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 56-169 3.84e-11

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 56.44  E-value: 3.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886500574  56 LPQGLALGPSLVEKQRLGVWCVgKPLQPGLLWGPLgeeaaseqkdEGVQprqeedvslglwgdvcacerssGWTSLVQRG 135
Cdd:cd10534     1 LPAGLELVLSSIPEGGLGVFAR-RTIPAGTRFGPL----------EGVV----------------------NWMRFVRPA 47

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1886500574 136 RLEGEGNVAPVWISERLHLQVYRVVLPGFELLLW 169
Cdd:cd10534    48 RNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVW 81
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 53-169 2.52e-08

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 49.75  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886500574  53 LKTLPQGLALGPSLVEKQRLGVWCVgKPLQPGLLWGPLGEEaaSEQKDEGVQPRQEEDVSLGLWGDVC--ACERSSG-WT 129
Cdd:cd19188     1 LMGLPEELELKPSAVDKTRIGVWAK-KSIPKGRKFGPFVGE--KKKRSQVKNNVYMWEIYGPKRGWMCvdASDPTKGnWL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1886500574 130 SLVQRGRLEGEGNVAPVWISERLHLQVYRVVLPGFELLLW 169
Cdd:cd19188    78 RYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCW 117
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 54-169 1.19e-03

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 37.21  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886500574  54 KTLPQGLALGPSLVEKQRLGVWCvGKPLQPGLLWGP-----LGEEAASE-----QKDEGVQPRQEEDVSLglwgdvcacE 123
Cdd:cd19193     2 LTLPPGLSIKRSSIPGAGLGVWA-EAPIPKGMVFGPyegeiVEDEEAADsgyswQIYKGGKLSHYIDAKD---------E 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1886500574 124 RSSGWTSLVQRGRLEGEGNVAPVWISERLHLQVYRVVLPGFELLLW 169
Cdd:cd19193    72 SKSNWMRYVNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVW 117
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 80-170 1.45e-03

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 36.94  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886500574  80 PLQPGLLWGP----LGEEAASEQKDEGVQPRQeedvSLGLWGDVCACERSSGWTSLVQRGRLEGEGNVAPVWISERLHLQ 155
Cdd:cd19201    27 PLPEGTRFGPypgkLVKEPLDPSYEWKVEAQG----SKGGEGLLLLTEDSGTWLKLVRSADDEDEANLILYFKGGQIWCE 102

                          90
                  ....*....|....*
gi 1886500574 156 VYRVVLPGFELLLWP 170
Cdd:cd19201   103 VTKDIPPGEELILVL 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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