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Conserved domains on  [gi|1945772487|gb|KAG0265551|]
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Chitin synthase, class 5 [Actinomortierella ambigua]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 12990738)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-5 receptor subunit alpha and interferon gamma receptor 2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chs5_N cd13945
N-terminal dimerization domain of Chs5 and similar proteins; Chs5/6 is a multi-protein complex ...
 22-94 2.19e-42

N-terminal dimerization domain of Chs5 and similar proteins; Chs5/6 is a multi-protein complex conserved in fungi that interacts with chitin synthase III (Chs3p) and is involved in its transport to the cell surface from the trans-Golgi network, functioning as an exomer cargo adapter. Chs5p appears to form a complex with Chs6p and its paralogs Bch1p, Bud7p, and Bch2p. In this complex, Chs5p may act as a central scaffold. The N-terminal domain characterized by this model forms a homodimer and has been shown to interact with Chs6p and Bch1p. It may function as a flexible hinge domain that allows the exomer to interact with both proteins and the Golgi membrane as the latter undergoes changes in curvature during the formation of transport vesicles. The dimerization domain sits N-terminally to a conserved FBE (FN3-BRCT) unit, which binds Arf1 an is involved in the recruitment of the exomer to the membrane.


:

Pssm-ID: 260117  Cd Length: 73  Bit Score: 140.01  E-value: 2.19e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1945772487  22 TSVQFTVGKLDAGMVILLTEDHHLIEFPSLLLPKGVTAGSVVNISVNRNLDEEQRRRDEFWQLQDEILEQFGT 94
Cdd:cd13945     1 VEVSLTVGKLDAGLAILLTSDHHLIEFPSVLLPPGIKAGSIVKITVSRNLEAEKKEEEEFQSLQKEILETYGT 73
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 95-184 5.86e-39

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam16893:

Pssm-ID: 473895  Cd Length: 89  Bit Score: 131.94  E-value: 5.86e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945772487  95 NPPKAPTLRVVTLTQSTCILEWDPLVLNAASLRSLKVFKNGVRHGpPIANPFHVNQVKLSGLDISHEYSFFIELRTSAGT 174
Cdd:pfam16893   1 NSPKAPVLKVRNVTQTSVVLEWDPLELGTAKLKSLDLYRNGQRLG-VIPNPLTNTSTKLSGLSVDTEYTFQLVLRTTAGT 79

                          90
                  ....*....|
gi 1945772487 175 LKSNEVRART 184
Cdd:pfam16893  80 YWSNKIKVRT 89
BRCT_CHS5_like cd17742
BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...
 191-267 3.85e-30

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.


:

Pssm-ID: 349373 [Multi-domain]  Cd Length: 77  Bit Score: 108.57  E-value: 3.85e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1945772487 191 SGINVCFGVFESDKDLDECKQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQQSIPIVKPDWLRACVEQKKLQ 267
Cdd:cd17742     1 SGITVCLGPLDPPESVDELEQCLERIGAKPTDRVAIDTTHFVCTVPSGPEYEKAKEMNIPIVRPEWLRACEVEKKIV 77
 
Name Accession Description Interval E-value
Chs5_N cd13945
N-terminal dimerization domain of Chs5 and similar proteins; Chs5/6 is a multi-protein complex ...
 22-94 2.19e-42

N-terminal dimerization domain of Chs5 and similar proteins; Chs5/6 is a multi-protein complex conserved in fungi that interacts with chitin synthase III (Chs3p) and is involved in its transport to the cell surface from the trans-Golgi network, functioning as an exomer cargo adapter. Chs5p appears to form a complex with Chs6p and its paralogs Bch1p, Bud7p, and Bch2p. In this complex, Chs5p may act as a central scaffold. The N-terminal domain characterized by this model forms a homodimer and has been shown to interact with Chs6p and Bch1p. It may function as a flexible hinge domain that allows the exomer to interact with both proteins and the Golgi membrane as the latter undergoes changes in curvature during the formation of transport vesicles. The dimerization domain sits N-terminally to a conserved FBE (FN3-BRCT) unit, which binds Arf1 an is involved in the recruitment of the exomer to the membrane.


Pssm-ID: 260117  Cd Length: 73  Bit Score: 140.01  E-value: 2.19e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1945772487  22 TSVQFTVGKLDAGMVILLTEDHHLIEFPSLLLPKGVTAGSVVNISVNRNLDEEQRRRDEFWQLQDEILEQFGT 94
Cdd:cd13945     1 VEVSLTVGKLDAGLAILLTSDHHLIEFPSVLLPPGIKAGSIVKITVSRNLEAEKKEEEEFQSLQKEILETYGT 73
fn3_2 pfam16893
Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin ...
 95-184 5.86e-39

Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin biosynthesis protein CHS5 where, together with the neighbouring BRCT domain (pfam00533), it binds to the Arf1 GTPase.


Pssm-ID: 435634  Cd Length: 89  Bit Score: 131.94  E-value: 5.86e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945772487  95 NPPKAPTLRVVTLTQSTCILEWDPLVLNAASLRSLKVFKNGVRHGpPIANPFHVNQVKLSGLDISHEYSFFIELRTSAGT 174
Cdd:pfam16893   1 NSPKAPVLKVRNVTQTSVVLEWDPLELGTAKLKSLDLYRNGQRLG-VIPNPLTNTSTKLSGLSVDTEYTFQLVLRTTAGT 79

                          90
                  ....*....|
gi 1945772487 175 LKSNEVRART 184
Cdd:pfam16893  80 YWSNKIKVRT 89
BRCT_CHS5_like cd17742
BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...
 191-267 3.85e-30

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.


Pssm-ID: 349373 [Multi-domain]  Cd Length: 77  Bit Score: 108.57  E-value: 3.85e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1945772487 191 SGINVCFGVFESDKDLDECKQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQQSIPIVKPDWLRACVEQKKLQ 267
Cdd:cd17742     1 SGITVCLGPLDPPESVDELEQCLERIGAKPTDRVAIDTTHFVCTVPSGPEYEKAKEMNIPIVRPEWLRACEVEKKIV 77
CHS5_N pfam16892
Chitin biosynthesis protein CHS5 N-terminus; This domain is found at the N-terminus of fungal ...
 23-70 2.39e-27

Chitin biosynthesis protein CHS5 N-terminus; This domain is found at the N-terminus of fungal chitin biosynthesis protein CHS5. It functions as a dimerization domain.


Pssm-ID: 407128  Cd Length: 48  Bit Score: 100.43  E-value: 2.39e-27
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1945772487  23 SVQFTVGKLDAGMVILLTEDHHLIEFPSLLLPKGVTAGSVVNISVNRN 70
Cdd:pfam16892   1 EVTFTVGKLDAGMAILLTSDHHLIEFPSVLLPPGVTAGSIVDISVSRN 48
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 190-261 2.61e-09

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 52.68  E-value: 2.61e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1945772487 190 LSGINVCFGVFeSDKDLDECKQLVEQIGGHWTDEVGIETTHLLCHvQGGYNYEAALQQSIPIVKPDWLRACV 261
Cdd:pfam00533   6 FSGKTFVITGL-DGLERDELKELIEKLGGKVTDSLSKKTTHVIVE-ARTKKYLKAKELGIPIVTEEWLLDCI 75
BRCT smart00292
breast cancer carboxy-terminal domain;
190-261 2.81e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 50.07  E-value: 2.81e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1945772487  190 LSGINVCFGVFESDKDLDECKQLVEQIGGHWTDEV-GIETTHLLCHVQGG--YNYEAALQQSIPIVKPDWLRACV 261
Cdd:smart00292   4 FKGKTFYITGSFDKEERDELKELIEALGGKVTSSLsSKTTTHVIVGSPEGgkLELLKAIALGIPIVKEEWLLDCL 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 97-184 3.95e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 35.94  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945772487  97 PKAPT-LRVVTLTQSTCILEWDPLVLNAASLRSLKVFKNGVRHGPPI---ANPFHVNQVKLSGLDISHEYSFFIELRTSA 172
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 1945772487 173 GT-LKSNEVRART 184
Cdd:cd00063    81 GEsPPSESVTVTT 93
PLN03122 PLN03122
Poly [ADP-ribose] polymerase; Provisional
 236-285 6.32e-03

Poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 178669 [Multi-domain]  Cd Length: 815  Bit Score: 38.24  E-value: 6.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1945772487 236 QGGYNYEA-ALQQSIPIVKPDWLRACVEQKKLQAASPYYLVQPASSNQSDI 285
Cdd:PLN03122  238 RGGSSKIAeAMERGIPVVREAWLIDSIEKQEAQPLEAYDVVSDLSVEGRGI 288
 
Name Accession Description Interval E-value
Chs5_N cd13945
N-terminal dimerization domain of Chs5 and similar proteins; Chs5/6 is a multi-protein complex ...
 22-94 2.19e-42

N-terminal dimerization domain of Chs5 and similar proteins; Chs5/6 is a multi-protein complex conserved in fungi that interacts with chitin synthase III (Chs3p) and is involved in its transport to the cell surface from the trans-Golgi network, functioning as an exomer cargo adapter. Chs5p appears to form a complex with Chs6p and its paralogs Bch1p, Bud7p, and Bch2p. In this complex, Chs5p may act as a central scaffold. The N-terminal domain characterized by this model forms a homodimer and has been shown to interact with Chs6p and Bch1p. It may function as a flexible hinge domain that allows the exomer to interact with both proteins and the Golgi membrane as the latter undergoes changes in curvature during the formation of transport vesicles. The dimerization domain sits N-terminally to a conserved FBE (FN3-BRCT) unit, which binds Arf1 an is involved in the recruitment of the exomer to the membrane.


Pssm-ID: 260117  Cd Length: 73  Bit Score: 140.01  E-value: 2.19e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1945772487  22 TSVQFTVGKLDAGMVILLTEDHHLIEFPSLLLPKGVTAGSVVNISVNRNLDEEQRRRDEFWQLQDEILEQFGT 94
Cdd:cd13945     1 VEVSLTVGKLDAGLAILLTSDHHLIEFPSVLLPPGIKAGSIVKITVSRNLEAEKKEEEEFQSLQKEILETYGT 73
fn3_2 pfam16893
Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin ...
 95-184 5.86e-39

Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin biosynthesis protein CHS5 where, together with the neighbouring BRCT domain (pfam00533), it binds to the Arf1 GTPase.


Pssm-ID: 435634  Cd Length: 89  Bit Score: 131.94  E-value: 5.86e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945772487  95 NPPKAPTLRVVTLTQSTCILEWDPLVLNAASLRSLKVFKNGVRHGpPIANPFHVNQVKLSGLDISHEYSFFIELRTSAGT 174
Cdd:pfam16893   1 NSPKAPVLKVRNVTQTSVVLEWDPLELGTAKLKSLDLYRNGQRLG-VIPNPLTNTSTKLSGLSVDTEYTFQLVLRTTAGT 79

                          90
                  ....*....|
gi 1945772487 175 LKSNEVRART 184
Cdd:pfam16893  80 YWSNKIKVRT 89
BRCT_CHS5_like cd17742
BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...
 191-267 3.85e-30

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.


Pssm-ID: 349373 [Multi-domain]  Cd Length: 77  Bit Score: 108.57  E-value: 3.85e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1945772487 191 SGINVCFGVFESDKDLDECKQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQQSIPIVKPDWLRACVEQKKLQ 267
Cdd:cd17742     1 SGITVCLGPLDPPESVDELEQCLERIGAKPTDRVAIDTTHFVCTVPSGPEYEKAKEMNIPIVRPEWLRACEVEKKIV 77
CHS5_N pfam16892
Chitin biosynthesis protein CHS5 N-terminus; This domain is found at the N-terminus of fungal ...
 23-70 2.39e-27

Chitin biosynthesis protein CHS5 N-terminus; This domain is found at the N-terminus of fungal chitin biosynthesis protein CHS5. It functions as a dimerization domain.


Pssm-ID: 407128  Cd Length: 48  Bit Score: 100.43  E-value: 2.39e-27
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1945772487  23 SVQFTVGKLDAGMVILLTEDHHLIEFPSLLLPKGVTAGSVVNISVNRN 70
Cdd:pfam16892   1 EVTFTVGKLDAGMAILLTSDHHLIEFPSVLLPPGVTAGSIVDISVSRN 48
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 190-264 6.65e-11

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 57.16  E-value: 6.65e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1945772487 190 LSGINVCFGVFESDkDLDECKQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQ-QSIPIVKPDWLRACVEQK 264
Cdd:cd17731     3 FKGLVICVTGFDSE-ERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKwNSIHIVTPEWLYDSIEAG 77
BRCT_CTDP1 cd17729
BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ...
 178-263 3.03e-10

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.


Pssm-ID: 349361 [Multi-domain]  Cd Length: 97  Bit Score: 56.00  E-value: 3.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945772487 178 NEVRARThtldnLSGINVCF-GVFESDKDLDEC--KQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQQ-SIPIVK 253
Cdd:cd17729     7 PELRSKV-----LKGCVIVFsGVIPTGIDPERSrlWKLAESLGAKVVTDLSPRTTHLVAAKLGTEKVKQALKMpGIHVVH 81

                          90
                  ....*....|
gi 1945772487 254 PDWLRACVEQ 263
Cdd:cd17729    82 PDWLWACAER 91
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 193-260 3.07e-10

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 55.06  E-value: 3.07e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1945772487 193 INVCFGVFeSDKDLDECKQLVEQIGGHWTDEVGIETTHLLC-HVQGGYNYEAALQQSIPIVKPDWLRAC 260
Cdd:cd00027     1 LVICFSGL-DDEEREELKKLIEALGGKVSESLSSKVTHLIAkSPSGEKYYLAALAWGIPIVSPEWLLDC 68
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 190-261 2.61e-09

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 52.68  E-value: 2.61e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1945772487 190 LSGINVCFGVFeSDKDLDECKQLVEQIGGHWTDEVGIETTHLLCHvQGGYNYEAALQQSIPIVKPDWLRACV 261
Cdd:pfam00533   6 FSGKTFVITGL-DGLERDELKELIEKLGGKVTDSLSKKTTHVIVE-ARTKKYLKAKELGIPIVTEEWLLDCI 75
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 195-256 1.11e-08

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 50.66  E-value: 1.11e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1945772487 195 VCFGVFeSDKDLDECKQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQQSIPIVKPDW 256
Cdd:pfam12738   3 ICVTGF-DGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT smart00292
breast cancer carboxy-terminal domain;
190-261 2.81e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 50.07  E-value: 2.81e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1945772487  190 LSGINVCFGVFESDKDLDECKQLVEQIGGHWTDEV-GIETTHLLCHVQGG--YNYEAALQQSIPIVKPDWLRACV 261
Cdd:smart00292   4 FKGKTFYITGSFDKEERDELKELIEALGGKVTSSLsSKTTTHVIVGSPEGgkLELLKAIALGIPIVKEEWLLDCL 78
BRCT_Ect2_rpt1 cd17733
first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar ...
 190-264 3.60e-07

first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins; ECT2 is a guanine nucleotide exchange factor (GEF) for Rho GTPases, phosphorylated in G2/M phases, and is involved in the regulation of cytokinesis. It contains two tandem BRCT domains. The family corresponds to the first BRCT domain.


Pssm-ID: 349365 [Multi-domain]  Cd Length: 76  Bit Score: 46.94  E-value: 3.60e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1945772487 190 LSGINVCFGVFESDKDLDECKQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQQSIPIVKPDWLRACVEQK 264
Cdd:cd17733     1 MENLVLCFTGFRKKEELSRLVNLVHHMGGSIRKDFSSKVTHLVANSTQGEKYRVAVSLGTPIMTEDWIYKAWEKR 75
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 190-267 3.77e-07

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 46.84  E-value: 3.77e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1945772487 190 LSGINVCFGVFeSDKDLDECKQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQ-QSIPIVKPDWLRACVEQKKLQ 267
Cdd:cd17710     2 FSGVVVCPSQI-SAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECALKhEGIKIVTPDWVTDCIKAKTLL 79
BRCT_PAXIP1_rpt4 cd17730
fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 202-261 4.00e-07

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain.


Pssm-ID: 349362 [Multi-domain]  Cd Length: 73  Bit Score: 46.47  E-value: 4.00e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945772487 202 SDKDLDECKQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQQSIPIVKPDWLRACV 261
Cdd:cd17730     9 DGSEREDIKRMIELMGAKYTGYLTRSNTHLICKRPEGEKYEKAKEWRIPVVNAQWLEDIL 68
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 207-272 5.04e-06

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 43.89  E-value: 5.04e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1945772487 207 DECKQLVEQIGGHWTDEVGIETTHLLCHVqgGYNYEAALQQSIPIVKPDWLRACVEQKKLQAASPY 272
Cdd:pfam16589  21 SKLKRLIEANGGTVVDNINPAVYIVIAPY--NKTDKLAENTKLGVVSPQWIFDCVKKGKLLPLENY 84
BRCT_BRC1_like_rpt4 cd18438
fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 210-261 4.81e-05

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.


Pssm-ID: 349391 [Multi-domain]  Cd Length: 68  Bit Score: 40.83  E-value: 4.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1945772487 210 KQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQQSIPIVKPDWLRACV 261
Cdd:cd18438    17 EKLILALGATYTKNLKPDNTHLITASPEGEKYEAAKEWNIPIVNHLWLYDSY 68
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
 202-274 2.74e-04

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 39.09  E-value: 2.74e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1945772487 202 SDKDLDECKQLVEQIGGHWTD-EVGIETTHLLC-HVQGGYNYEAALQQSIPIVKPDWLRACVEQKKLQAASPYYL 274
Cdd:cd17719    13 TDPSADELKRLILLHGGQYEHyYSRSRVTHIIAtNLPGSKIKKLKKARNYKVVRPEWIVDSIKAGRLLPEAPYLL 87
BRCT_TopBP1_rpt5 cd18434
fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 228-265 3.71e-04

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fifth BRCT domain.


Pssm-ID: 349387  Cd Length: 89  Bit Score: 38.82  E-value: 3.71e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1945772487 228 TTHLLCHVQGGYNYEAALQQSIPIVKPDWLRACVEQKK 265
Cdd:cd18434    48 STHLVLKEPEGSKYEAAKKWNLPAVTKSWLFECARTGK 85
BRCT_nibrin cd17741
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...
 202-262 4.18e-04

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.


Pssm-ID: 349372 [Multi-domain]  Cd Length: 74  Bit Score: 38.35  E-value: 4.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1945772487 202 SDKDLDECKQLVEQIGGHWTDEVGIETTHL-----------LChvqggynyeaALQQSIPIVKPDWLRACVE 262
Cdd:cd17741    11 DSEEKKKLKQIIAKLGGKVVNEWTEECTHLvmskikvtvkvIC----------ALISGKPIVTPEYLDALLE 72
BRCT_BRC1_like_rpt2 cd18436
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 213-261 4.91e-04

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.


Pssm-ID: 349389 [Multi-domain]  Cd Length: 75  Bit Score: 37.98  E-value: 4.91e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1945772487 213 VEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQQS---IPIVKPDWLRACV 261
Cdd:cd18436    23 VLALGGQYSDELTRDVTHLIALSPDGDKYKTALKRPelnIKIVLPHWFDDCF 74
BRCT_MDC1_rpt1 cd17744
first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
 204-267 6.65e-04

first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the first BRCT domain.


Pssm-ID: 349375 [Multi-domain]  Cd Length: 72  Bit Score: 37.60  E-value: 6.65e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1945772487 204 KDLDECKQLVEQIGGHWTDEVgIETTHL-----------LChvqggynyeaALQQSIPIVKPDWLRACVEQKKLQ 267
Cdd:cd17744     9 SDKEEGEKIIKKLGGSVVDSV-EDCTHLvtdkvrrtvkfLC----------ALARGIPIVSPDWLEASIKANKFL 72
BRCT_Rad4_rpt2 cd17746
second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 208-267 6.92e-04

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.


Pssm-ID: 349377 [Multi-domain]  Cd Length: 91  Bit Score: 37.99  E-value: 6.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1945772487 208 ECKQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQQSIPIVKPDWL------RACVEQKKLQ 267
Cdd:cd17746    24 RIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKWKINVVCVEWLwqsiqrNAVLEPQYFQ 89
DUF3006 pfam11213
Protein of unknown function (DUF3006); This family of proteins has no known function.
 34-87 1.07e-03

Protein of unknown function (DUF3006); This family of proteins has no known function.


Pssm-ID: 463240  Cd Length: 67  Bit Score: 36.71  E-value: 1.07e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1945772487  34 GMVILLTEDHHLIEFPSLLLPKGVTAGSVVNIS---VNRNLDEEQRRRDEFWQLQDE 87
Cdd:pfam11213   9 DYAVLELEDGEMINIPRSLLPEGAKEGDVLEIEndkIEIDPEETEKRKERIEELLDR 65
BRCT_PARP4_like cd17726
BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins; PARP-4, also ...
 208-266 1.59e-03

BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins; PARP-4, also termed 193 kDa vault protein, or ADP-ribosyltransferase diphtheria toxin-like 4 (ARTD4), or PARP-related/IalphaI-related H5/proline-rich (PH5P), or vault poly(ADP-ribose) polymerase (VPARP), shows poly(ADP-ribosyl)ation activity that catalyzes the formation of ADP-ribose polymers in response to DNA damage. PARP-4 is a component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group.


Pssm-ID: 349358 [Multi-domain]  Cd Length: 85  Bit Score: 36.88  E-value: 1.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1945772487 208 ECKQLVEQIGGHWTDEVGIETTHLL---CHVQGGYNYEAALQQSIPIVKPDWLRACVEQKKL 266
Cdd:cd17726    22 KLKKKITENGGIISYIINKKCTHVVvnnAKALSSYKCRMAQKYGIPVVSLDYIWKCVEAGKL 83
BRCT_XRCC1_rpt2 cd17707
Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and ...
 240-275 2.32e-03

Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This model corresponds to the second BRCT domain.


Pssm-ID: 349340  Cd Length: 94  Bit Score: 36.48  E-value: 2.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1945772487 240 NYEAALQ--QSIPIVKPDWLRACVEQKKLQAASPYYLV 275
Cdd:cd17707    56 NFDEALAenPSLAFVRPRWIYACHEKQKLLPCQPYLVV 93
BRCT_DNA_ligase_III cd18431
BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ...
 187-268 3.60e-03

BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ligase III, or polydeoxyribonucleotide synthase [ATP] 3, functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.


Pssm-ID: 349384 [Multi-domain]  Cd Length: 78  Bit Score: 35.75  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945772487 187 LDNLSGINVCFGVfESDKDLDECKQLVEQIGGHWTDEVGIE-TTHLLchvqgGYNYEAALQQSIPIVKPDWLRACVEQKK 265
Cdd:cd18431     2 PDIFTGVKVYLPG-SVEDDYKKLKRYFIAYDGDVVEEYDEEdATHVV-----VDRDDKLGNPSAKVVSPEWLWDCIKKQK 75


                  ...
gi 1945772487 266 LQA 268
Cdd:cd18431    76 LVP 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 97-184 3.95e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 35.94  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945772487  97 PKAPT-LRVVTLTQSTCILEWDPLVLNAASLRSLKVFKNGVRHGPPI---ANPFHVNQVKLSGLDISHEYSFFIELRTSA 172
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 1945772487 173 GT-LKSNEVRART 184
Cdd:cd00063    81 GEsPPSESVTVTT 93
BRCT_PAXIP1_rpt3 cd17711
third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 197-266 5.56e-03

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.


Pssm-ID: 349343  Cd Length: 81  Bit Score: 35.32  E-value: 5.56e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945772487 197 FGVFESDKDLDECKQLVEQIGGHWTDEVGIETTHLLCHVQGGYNYEAALQQSIPIVKPDWLRACVEQKKL 266
Cdd:cd17711     9 YPEQMGDQEIATWKKVIEEHGGEVVDEYSPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKL 78
PLN03122 PLN03122
Poly [ADP-ribose] polymerase; Provisional
 236-285 6.32e-03

Poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 178669 [Multi-domain]  Cd Length: 815  Bit Score: 38.24  E-value: 6.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1945772487 236 QGGYNYEA-ALQQSIPIVKPDWLRACVEQKKLQAASPYYLVQPASSNQSDI 285
Cdd:PLN03122  238 RGGSSKIAeAMERGIPVVREAWLIDSIEKQEAQPLEAYDVVSDLSVEGRGI 288
BRCT_TopBP1_rpt6 cd17727
sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 190-260 7.71e-03

sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the sixth BRCT domain.


Pssm-ID: 349359 [Multi-domain]  Cd Length: 75  Bit Score: 34.49  E-value: 7.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945772487 190 LSGINVCFgvfeSDKDLD---ECKQLVEQIGGH--WT-DEvgiETTHLLChvQGGYN-----YEAALQQSIPIVKPDWLR 258
Cdd:cd17727     1 LKGVVICV----SKKLSKrqgELNKIAASLGAEyrWTyDE---SCTHFIY--QGKANdtnreYKSAKEQGKFIVSPHWLY 71


                  ..
gi 1945772487 259 AC 260
Cdd:cd17727    72 AC 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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