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Conserved domains on  [gi|2095537676|gb|KAH0504282|]
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Clathrin heavy chain 1 [Microtus ochrogaster]

Protein Classification

clathrin heavy chain( domain architecture ID 12019188)

clathrin heavy chain is a component of clathrin, the major protein of the polyhedral coat of coated pits and vesicles

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1275-1417 7.15e-41

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 147.42  E-value: 7.15e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1275 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1354
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2095537676  1355 QAHLWAELVFLYDKYEEYDNAIITMMNHPTDAwkeGQFKDIITKVANVELYYRAIQFYLEFKP 1417
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
980-1119 1.87e-35

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 132.01  E-value: 1.87e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676   980 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYI-NRLDNYDAPDIAN 1058
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095537676  1059 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQK 1119
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
1129-1266 2.79e-34

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 128.93  E-value: 2.79e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1129 YIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARE-SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCY 1207
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1208 DEKMYDAAKLLYNNVSNFGRLASTLV-HLGEYQAAVDGARKANSTRTWKEVCFACVDGKE 1266
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
775-913 1.86e-33

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 126.23  E-value: 1.86e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676   775 ASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNF-SQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLK 853
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095537676   854 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 913
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 445-510 6.94e-32

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


:

Pssm-ID: 463995  Cd Length: 66  Bit Score: 119.24  E-value: 6.94e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2095537676  445 NLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 510
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
CLH smart00299
Clathrin heavy chain repeat homology;
630-763 1.60e-30

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 118.15  E-value: 1.60e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676   630 EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNrPSEGPLQTRLLEMNLMHAPQVADAILGNqMFTHYDRAHIAQLCEKA 709
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2095537676   710 GLLQRALEHFTDLYDIKRAVVHT--HLLNPEWLVNYFGS-LSVEDSLECLRAMLSAN 763
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1428-1592 1.41e-26

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 106.96  E-value: 1.41e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1428 SPRLDHTRAVNYFSKVKQLPLVKPYLRSVQN---HNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHE 1504
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1505 LIEFRRiaaYLFKGNNRWKQSVELCKKDSLYKvdkvgvgclsnsdgiftsdviellvpwDAMQYASESKDTELAEELLQW 1584
Cdd:pfam00637   85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYK---------------------------DAIEYAVKSSNPELWEELLEA 134


                   ....*...
gi 2095537676 1585 FLQEEKRE 1592
Cdd:pfam00637  135 LLDNGRFE 142
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 420-443 3.35e-10

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


:

Pssm-ID: 462732  Cd Length: 24  Bit Score: 56.30  E-value: 3.35e-10
                           10        20
                   ....*....|....*....|....
gi 2095537676  420 EENIIPYITNVLQNPDLALRMAVR 443
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 287-323 2.32e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 48.57  E-value: 2.32e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2095537676  287 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 323
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 108-145 3.84e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 3.84e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2095537676  108 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 145
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 345-377 3.99e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 3.99e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2095537676  345 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 377
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 385-419 1.56e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.48  E-value: 1.56e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2095537676  385 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 419
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 237-276 1.36e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.78  E-value: 1.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2095537676  237 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 276
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1275-1417 7.15e-41

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 147.42  E-value: 7.15e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1275 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1354
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2095537676  1355 QAHLWAELVFLYDKYEEYDNAIITMMNHPTDAwkeGQFKDIITKVANVELYYRAIQFYLEFKP 1417
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
980-1119 1.87e-35

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 132.01  E-value: 1.87e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676   980 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYI-NRLDNYDAPDIAN 1058
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095537676  1059 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQK 1119
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
1129-1266 2.79e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 128.93  E-value: 2.79e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1129 YIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARE-SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCY 1207
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1208 DEKMYDAAKLLYNNVSNFGRLASTLV-HLGEYQAAVDGARKANSTRTWKEVCFACVDGKE 1266
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
775-913 1.86e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 126.23  E-value: 1.86e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676   775 ASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNF-SQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLK 853
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095537676   854 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 913
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 980-1120 1.95e-32

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 123.52  E-value: 1.95e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  980 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYINRLDNYDAPDIAN 1058
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095537676 1059 IAISNELFEEAFAIFRKFDVNTSAVqVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKG 1120
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1129-1268 2.91e-32

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 123.14  E-value: 2.91e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1129 YIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARE--SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRC 1206
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095537676 1207 YDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFR 1268
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 445-510 6.94e-32

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 119.24  E-value: 6.94e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2095537676  445 NLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 510
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
CLH smart00299
Clathrin heavy chain repeat homology;
630-763 1.60e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 118.15  E-value: 1.60e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676   630 EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNrPSEGPLQTRLLEMNLMHAPQVADAILGNqMFTHYDRAHIAQLCEKA 709
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2095537676   710 GLLQRALEHFTDLYDIKRAVVHT--HLLNPEWLVNYFGS-LSVEDSLECLRAMLSAN 763
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1275-1417 9.34e-28

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 110.04  E-value: 9.34e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1275 LHIVVHADELEELINYYQDRGYFEELITMLEAALGL-ERAHMGMFTELAILYSKF-KPQKMREHLELFWSrVNIPKVLRA 1352
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2095537676 1353 AEQAHLWAELVFLYDKYEEYDNAIitMMNHPTDAWKEGQfkDIITKVANVELYYRAIQFYLEFKP 1417
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 777-915 2.01e-27

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 109.27  E-value: 2.01e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  777 KYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFS--QDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKE 854
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095537676  855 AKLTDQLPLIIVCdrFDFVHDLV-LYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSE 915
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1428-1592 1.41e-26

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 106.96  E-value: 1.41e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1428 SPRLDHTRAVNYFSKVKQLPLVKPYLRSVQN---HNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHE 1504
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1505 LIEFRRiaaYLFKGNNRWKQSVELCKKDSLYKvdkvgvgclsnsdgiftsdviellvpwDAMQYASESKDTELAEELLQW 1584
Cdd:pfam00637   85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYK---------------------------DAIEYAVKSSNPELWEELLEA 134


                   ....*...
gi 2095537676 1585 FLQEEKRE 1592
Cdd:pfam00637  135 LLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 630-767 1.03e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 101.56  E-value: 1.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  630 EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAP-QVADAILgnQMFTHYDRAHIAQLCEK 708
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  709 AGLLQRALEHFTDLYDIKRAV-VHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQN 767
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1428-1606 2.49e-18

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 83.09  E-value: 2.49e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1428 SPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNnkSVNESLNNLFITEEDYQALRTSIDAYDNFdnislaqrlekHELIE 1507
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1508 FRRIAAYLFKGNNrWKQSVELCKKDSLYKvdkvgvgclsnsdgiftsDVIELLVpwdamqyasesKDTELAEELLQWFLQ 1587
Cdd:smart00299   72 IEKVGKLCEKAKL-YEEAVELYKKDGNFK------------------DAIVTLI-----------EHLGNYEKAIEYFVK 121

                           170
                    ....*....|....*....
gi 2095537676  1588 EEKRECFGACLFTCYDLLR 1606
Cdd:smart00299  122 QNNPELWAEVLKALLDKPR 140
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 420-443 3.35e-10

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 56.30  E-value: 3.35e-10
                           10        20
                   ....*....|....*....|....
gi 2095537676  420 EENIIPYITNVLQNPDLALRMAVR 443
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 287-323 2.32e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 48.57  E-value: 2.32e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2095537676  287 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 323
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1056-1220 4.06e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.58  E-value: 4.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1056 IANIAISNELFEEAFAIFRKF----DVNTSAVQVLI---EHIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMVK 1123
Cdd:COG2956     82 LAQDYLKAGLLDRAEELLEKLleldPDDAEALRLLAeiyEQEGDWEKAIEVLERLlklgpENAHAYCELAELYLEQGDYD 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1124 EAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESY-VETELIFALAKTNRLAELEEFI-----N 1192
Cdd:COG2956    162 EAIEALEKAlkldpDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLpALPRLAELYEKLGDPEEALELLrkaleL 241

                          170       180
                   ....*....|....*....|....*...
gi 2095537676 1193 GPNNAHIQQVGDRCYDEKMYDAAKLLYN 1220
Cdd:COG2956    242 DPSDDLLLALADLLERKEGLEAALALLE 269
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1062-1186 3.95e-06

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 51.31  E-value: 3.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1062 SNELFEEAFAIFR----KFDVntsAVQvliehIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSS 1137
Cdd:cd22947    324 SQGLKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSG 395

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2095537676 1138 YMEVVQAantSGNWEELVKYLQMARKK-----ARESYVET----ELIFALAKTNRLAE 1186
Cdd:cd22947    396 LLLLYSS---TGDKEGLEELAELAEAAgknniAFLAYFLLgdldKCVDLLIKTGRLPE 450
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 108-145 3.84e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 3.84e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2095537676  108 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 145
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 345-377 3.99e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 3.99e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2095537676  345 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 377
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 385-419 1.56e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.48  E-value: 1.56e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2095537676  385 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 419
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 237-276 1.36e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.78  E-value: 1.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2095537676  237 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 276
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1055-1165 1.53e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1055 DIANIAISNELFEEAFAIFRKF----DVNTSAVQVLIE---HIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMV 1122
Cdd:COG4783      9 ALAQALLLAGDYDEAEALLEKAleldPDNPEAFALLGEillQLGDLDEAIVLLHEAleldpDEPEARLNLGLALLKAGDY 88

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2095537676 1123 KEAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKA 1165
Cdd:COG4783     89 DEALALLEKAlkldpEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1055-1187 8.11e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 8.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1055 DIANIAISNELFEEAFAIFRKF-DVNTSAVQVLI------EHIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMV 1122
Cdd:COG3914    117 NLGNLLLALGRLEEALAALRRAlALNPDFAEAYLnlgealRRLGRLEEAIAALRRAleldpDNAEALNNLGNALQDLGRL 196

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1123 KEAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAEL 1187
Cdd:COG3914    197 EEAIAAYRRAleldpDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAEL 266
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1275-1417 7.15e-41

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 147.42  E-value: 7.15e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1275 LHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAE 1354
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2095537676  1355 QAHLWAELVFLYDKYEEYDNAIITMMNHPTDAwkeGQFKDIITKVANVELYYRAIQFYLEFKP 1417
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
980-1119 1.87e-35

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 132.01  E-value: 1.87e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676   980 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYI-NRLDNYDAPDIAN 1058
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095537676  1059 IAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQK 1119
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
CLH smart00299
Clathrin heavy chain repeat homology;
1129-1266 2.79e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 128.93  E-value: 2.79e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1129 YIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARE-SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCY 1207
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1208 DEKMYDAAKLLYNNVSNFGRLASTLV-HLGEYQAAVDGARKANSTRTWKEVCFACVDGKE 1266
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
775-913 1.86e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 126.23  E-value: 1.86e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676   775 ASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNF-SQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLK 853
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095537676   854 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRLPVVIGGLLDVDC 913
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 980-1120 1.95e-32

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 123.52  E-value: 1.95e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  980 LSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYINRLDNYDAPDIAN 1058
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095537676 1059 IAISNELFEEAFAIFRKFDVNTSAVqVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKG 1120
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1129-1268 2.91e-32

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 123.14  E-value: 2.91e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1129 YIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARE--SYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRC 1206
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095537676 1207 YDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFR 1268
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 445-510 6.94e-32

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 119.24  E-value: 6.94e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2095537676  445 NLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGIL 510
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
CLH smart00299
Clathrin heavy chain repeat homology;
630-763 1.60e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 118.15  E-value: 1.60e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676   630 EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNrPSEGPLQTRLLEMNLMHAPQVADAILGNqMFTHYDRAHIAQLCEKA 709
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2095537676   710 GLLQRALEHFTDLYDIKRAVVHT--HLLNPEWLVNYFGS-LSVEDSLECLRAMLSAN 763
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1275-1417 9.34e-28

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 110.04  E-value: 9.34e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1275 LHIVVHADELEELINYYQDRGYFEELITMLEAALGL-ERAHMGMFTELAILYSKF-KPQKMREHLELFWSrVNIPKVLRA 1352
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2095537676 1353 AEQAHLWAELVFLYDKYEEYDNAIitMMNHPTDAWKEGQfkDIITKVANVELYYRAIQFYLEFKP 1417
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 777-915 2.01e-27

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 109.27  E-value: 2.01e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  777 KYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFS--QDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKE 854
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095537676  855 AKLTDQLPLIIVCdrFDFVHDLV-LYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSE 915
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1428-1592 1.41e-26

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 106.96  E-value: 1.41e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1428 SPRLDHTRAVNYFSKVKQLPLVKPYLRSVQN---HNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHE 1504
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKedsRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1505 LIEFRRiaaYLFKGNNRWKQSVELCKKDSLYKvdkvgvgclsnsdgiftsdviellvpwDAMQYASESKDTELAEELLQW 1584
Cdd:pfam00637   85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYK---------------------------DAIEYAVKSSNPELWEELLEA 134


                   ....*...
gi 2095537676 1585 FLQEEKRE 1592
Cdd:pfam00637  135 LLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 630-767 1.03e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 101.56  E-value: 1.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  630 EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAP-QVADAILgnQMFTHYDRAHIAQLCEK 708
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  709 AGLLQRALEHFTDLYDIKRAV-VHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQN 767
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1428-1606 2.49e-18

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 83.09  E-value: 2.49e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1428 SPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNnkSVNESLNNLFITEEDYQALRTSIDAYDNFdnislaqrlekHELIE 1507
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676  1508 FRRIAAYLFKGNNrWKQSVELCKKDSLYKvdkvgvgclsnsdgiftsDVIELLVpwdamqyasesKDTELAEELLQWFLQ 1587
Cdd:smart00299   72 IEKVGKLCEKAKL-YEEAVELYKKDGNFK------------------DAIVTLI-----------EHLGNYEKAIEYFVK 121

                           170
                    ....*....|....*....
gi 2095537676  1588 EEKRECFGACLFTCYDLLR 1606
Cdd:smart00299  122 QNNPELWAEVLKALLDKPR 140
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 420-443 3.35e-10

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 56.30  E-value: 3.35e-10
                           10        20
                   ....*....|....*....|....
gi 2095537676  420 EENIIPYITNVLQNPDLALRMAVR 443
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 287-323 2.32e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 48.57  E-value: 2.32e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2095537676  287 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 323
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1056-1220 4.06e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.58  E-value: 4.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1056 IANIAISNELFEEAFAIFRKF----DVNTSAVQVLI---EHIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMVK 1123
Cdd:COG2956     82 LAQDYLKAGLLDRAEELLEKLleldPDDAEALRLLAeiyEQEGDWEKAIEVLERLlklgpENAHAYCELAELYLEQGDYD 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1124 EAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESY-VETELIFALAKTNRLAELEEFI-----N 1192
Cdd:COG2956    162 EAIEALEKAlkldpDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLpALPRLAELYEKLGDPEEALELLrkaleL 241

                          170       180
                   ....*....|....*....|....*...
gi 2095537676 1193 GPNNAHIQQVGDRCYDEKMYDAAKLLYN 1220
Cdd:COG2956    242 DPSDDLLLALADLLERKEGLEAALALLE 269
Coatomer_WDAD pfam04053
Coatomer WD associated region; This region is composed of WD40 repeats.
 1075-1186 3.63e-06

Coatomer WD associated region; This region is composed of WD40 repeats.


Pssm-ID: 427679  Cd Length: 439  Bit Score: 51.47  E-value: 3.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1075 KFDVntsAVQvliehIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSS----YMevvqaanTSGN 1150
Cdd:pfam04053  320 RFDL---ALE-----LGNLDVALEIAKELDDPAKWKRLGDAALSQGNIKLAEEAYQKAKDFDKllllYL-------STGN 384

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2095537676 1151 WEELVKYLQMARKKARES-------YVE--TELIFALAKTNRLAE 1186
Cdd:pfam04053  385 MEKLKKLAKIAEKRGDYNsafqnalYLGdvEKCVDILIKTGRLPE 429
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1062-1186 3.95e-06

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 51.31  E-value: 3.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1062 SNELFEEAFAIFR----KFDVntsAVQvliehIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSS 1137
Cdd:cd22947    324 SQGLKELALEVSTdpdhKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSG 395

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2095537676 1138 YMEVVQAantSGNWEELVKYLQMARKK-----ARESYVET----ELIFALAKTNRLAE 1186
Cdd:cd22947    396 LLLLYSS---TGDKEGLEELAELAEAAgknniAFLAYFLLgdldKCVDLLIKTGRLPE 450
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1057-1248 8.86e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.34  E-value: 8.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1057 ANIAISNELFEEAFAIFRK-FDVNTSAVQVLI------EHIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMVKE 1124
Cdd:COG2956     15 GLNYLLNGQPDKAIDLLEEaLELDPETVEAHLalgnlyRRRGEYDRAIRIHQKLlerdpDRAEALLELAQDYLKAGLLDR 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1125 AIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARES-YVETELIFALAKTNRLAE----LEEFING- 1193
Cdd:COG2956     95 AEELLEKLleldpDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEaieaLEKALKLd 174

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095537676 1194 PNNAHIQ-QVGDRCYDEKMYDAAKLLY--------NNVSNFGRLASTLVHLGEYQAAVDGARKA 1248
Cdd:COG2956    175 PDCARALlLLAELYLEQGDYEEAIAALeraleqdpDYLPALPRLAELYEKLGDPEEALELLRKA 238
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 108-145 3.84e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 3.84e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2095537676  108 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 145
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 345-377 3.99e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 42.02  E-value: 3.99e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2095537676  345 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 377
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1109-1376 4.53e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 4.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1109 WSQLAKAQLQKGMVKEAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESY-VETELIFALAKTN 1182
Cdd:COG2956     11 WYFKGLNYLLNGQPDKAIDLLEEAleldpETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAeALLELAQDYLKAG 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1183 RLAE----LEEFIN-GPNNAH-IQQVGDRCYDEKMYDAAKLLYNNVSNFG--------RLASTLVHLGEYQAAVDGARKA 1248
Cdd:COG2956     91 LLDRaeelLEKLLElDPDDAEaLRLLAEIYEQEGDWEKAIEVLERLLKLGpenahaycELAELYLEQGDYDEAIEALEKA 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1249 NSTRtwkevcfacvdgKEFRLAQMcglhivvhadeleELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKF 1328
Cdd:COG2956    171 LKLD------------PDCARALL-------------LLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKL 225

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2095537676 1329 -KPQKMREHLElfwsrvnipKVLRAAEQAHLWAELVFLYDKYEEYDNAI 1376
Cdd:COG2956    226 gDPEEALELLR---------KALELDPSDDLLLALADLLERKEGLEAAL 265
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 385-419 1.56e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.48  E-value: 1.56e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2095537676  385 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 419
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 237-276 1.36e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.78  E-value: 1.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2095537676  237 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 276
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1055-1165 1.53e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1055 DIANIAISNELFEEAFAIFRKF----DVNTSAVQVLIE---HIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMV 1122
Cdd:COG4783      9 ALAQALLLAGDYDEAEALLEKAleldPDNPEAFALLGEillQLGDLDEAIVLLHEAleldpDEPEARLNLGLALLKAGDY 88

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2095537676 1123 KEAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKA 1165
Cdd:COG4783     89 DEALALLEKAlkldpEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1055-1187 8.11e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 8.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1055 DIANIAISNELFEEAFAIFRKF-DVNTSAVQVLI------EHIGNLDRAYEFAERC-----NEPAVWSQLAKAQLQKGMV 1122
Cdd:COG3914    117 NLGNLLLALGRLEEALAALRRAlALNPDFAEAYLnlgealRRLGRLEEAIAALRRAleldpDNAEALNNLGNALQDLGRL 196

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095537676 1123 KEAIDSYIKA-----DDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAEL 1187
Cdd:COG3914    197 EEAIAAYRRAleldpDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAEL 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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