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Conserved domains on  [gi|2116459302|gb|KAH3627691|]
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hypothetical protein KXV56_002152 [Sartorya fumigata]

Protein Classification

exportin family protein( domain architecture ID 12047535)

exportin family protein is involved in the nuclear export of proteins that binds to a nuclear export signal (NES) on the target protein and then interacts with the GTPase RanGTP which allows the protein to be exported out of the nucleus.

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CAS_CSE1 pfam03378
CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are ...
522-960 0e+00

CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein, CSE1. This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation. Like CSE1, it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase), and has been shown to be associated with the microtubule network and the mitotic spindle, as is the protein MEK, which is thought to regulate the intracellular localization (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus, CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors), it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins.


:

Pssm-ID: 367469  Cd Length: 435  Bit Score: 707.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 522 ERVLYLADSQGQPIIAPATVTPLAKDLLQHIFSLIQKDPApekvQENEFLMRCAMRVLIVIKEDVVPYTDIVLQHLINIT 601
Cdd:pfam03378   1 ERLLTLRDEQGQPIFTSADIAPFAKDLLTHLFAAIEKPGS----QENEYLMKCIMRVLIVIQEAVLPVADVVLQHLTNIL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 602 DVISKNPSNPRFYYFHFEAMGAFIRFAAPANPE---KLEQALYPPFANILQGDVQEFMPYVFQLFAALLEANPSGSLPNY 678
Cdd:pfam03378  77 QEVSKNPSNPRFNHYLFEAIGALIRFACKADPAavsKFEEALFPPFQAILQEDVTEFMPYVFQLLAQLLEANPSGTLPDY 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 679 YQNLIAPMLMPVMWESKGNIPALVRLLSSIIPRGSQFILENQQLVPILGIFQKLLSTKANEGFGFDLLESVVENFPPTAL 758
Cdd:pfam03378 157 YMALFPPLLSPALWERRGNVPALVRLLSAFIPKASQEIVANNKLEPVLGIFQKLIASKANDHQGFYLLESVIENFPPEVL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 759 EQYFVSIMQVILTRLQNSKTEHLTLRFVRFYHFISAHddkgYSADYFIQVTDKVQADLFTPIYLNIILPETQKLARPLDR 838
Cdd:pfam03378 237 EPYFKTIFSLLFQRLQNSKTEKFVKRFVIFYHLYSAK----HGADFLIQLIDAIQPGVFGMIYLNVILPETQKLAGPLDR 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 839 KTAVLSFTKTLANSEAFANRYKKGWAFTCEALLKLLELPPLPAS--KDDIIAEHDVEDMAFGVGFTALNTVRPQPRDPWP 916
Cdd:pfam03378 313 KLAAVSYTKLLCESPAFADRYPKGWGFLLQSLLKLLELPPDPAAadEDDIIDEADVDDMGYGVGFTQLNTAGKKERDPFP 392
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2116459302 917 DtGADLKAWVGRYLKEADKKHNGRVSACVQERLGAEARTVLSSY 960
Cdd:pfam03378 393 D-IPDVKQWVGQSLKEASQAHPGRISQIISERLPPEAKQALQKY 435
Cse1 pfam08506
Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the ...
151-521 0e+00

Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the nuclear export of importin alpha. This domain contains HEAT repeats.


:

Pssm-ID: 430038 [Multi-domain]  Cd Length: 370  Bit Score: 565.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 151 IFKRWRPLFQSNELYTEINHVLNKFGNPFLALFEGLDSFLEENRSNKENLIQGFTQFNLMVKLLFDLSCHDLPPMFEENL 230
Cdd:pfam08506   1 IFKRWRPLFRSDELFLEIKLVLDKFAEPFLTLLQKVDELIEANKNNKASLKILFEVLLLLCKLFYDLNCQDIPEFFEDNM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 231 SGIASLLLKYLTYDNALLHTDDDTEAGQLEFVRAGIFEALTLYVQKYMDVFSSHVGQFVQSSWSFLTTIGQETKYDILVS 310
Cdd:pfam08506  81 KEWMGIFHKYLSYDNPLLETDDDEEATVLEKLKASICELVQLYTLRYEEEFGPMVNDFIQAVWNLLVSTSPQPKYDILVS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 311 KALQFLTSVAGMPEHASVFQAEETLGQIVEKVVLPNVSLRESDEELFEDEPIEFIRRDLEGSDSETRRRAATDFLRRLAE 390
Cdd:pfam08506 161 KALSFLTSVARRPKYAELFNNESVLKQIIEKVVLPNVTLRESDEELFEDDPIEYIRRDLEGSDSDTRRRAATDFLKELKE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 391 QFEGPVTKVVLRYSDHYLAEYSKSPATNWKAKDTAVYLFSAIAAKGvATASHGVTATNPLVSITDFFQKNLAADLVVDES 470
Cdd:pfam08506 241 KFEALVTNVVLEYIQRLLEKYSANPSLNWKAKDTAIYLFTSIAAKG-AVTKSGVTSTNPLVDVVDFFQQQIAPDLMANVN 319
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2116459302 471 AHPILKVDAIKYLYLFRSIITKDQWQEVLPLLVKHLGSPNFVVYTYAAIAV 521
Cdd:pfam08506 320 QHPILKADAIKYIYTFRNQLTKEQLIEIFPLLINFLQSSSYVVYTYAAITI 370
IBN_N pfam03810
Importin-beta N-terminal domain;
24-97 9.87e-12

Importin-beta N-terminal domain;


:

Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 61.10  E-value: 9.87e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2116459302  24 AEATLRQEEQKPGFSLQLLQITASTSYPYNTRLASALCFKNFIKRNWTDEDGnyKLQLDEVATIKRELISLMIS 97
Cdd:pfam03810   1 AEKQLEQFEKSPGFWSKLLQILSNSENPLEVRQLAALYLKNLITRHWEEEKN--SLPPEEKEQIKNNLLNLLGS 72
 
Name Accession Description Interval E-value
CAS_CSE1 pfam03378
CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are ...
522-960 0e+00

CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein, CSE1. This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation. Like CSE1, it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase), and has been shown to be associated with the microtubule network and the mitotic spindle, as is the protein MEK, which is thought to regulate the intracellular localization (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus, CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors), it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins.


Pssm-ID: 367469  Cd Length: 435  Bit Score: 707.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 522 ERVLYLADSQGQPIIAPATVTPLAKDLLQHIFSLIQKDPApekvQENEFLMRCAMRVLIVIKEDVVPYTDIVLQHLINIT 601
Cdd:pfam03378   1 ERLLTLRDEQGQPIFTSADIAPFAKDLLTHLFAAIEKPGS----QENEYLMKCIMRVLIVIQEAVLPVADVVLQHLTNIL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 602 DVISKNPSNPRFYYFHFEAMGAFIRFAAPANPE---KLEQALYPPFANILQGDVQEFMPYVFQLFAALLEANPSGSLPNY 678
Cdd:pfam03378  77 QEVSKNPSNPRFNHYLFEAIGALIRFACKADPAavsKFEEALFPPFQAILQEDVTEFMPYVFQLLAQLLEANPSGTLPDY 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 679 YQNLIAPMLMPVMWESKGNIPALVRLLSSIIPRGSQFILENQQLVPILGIFQKLLSTKANEGFGFDLLESVVENFPPTAL 758
Cdd:pfam03378 157 YMALFPPLLSPALWERRGNVPALVRLLSAFIPKASQEIVANNKLEPVLGIFQKLIASKANDHQGFYLLESVIENFPPEVL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 759 EQYFVSIMQVILTRLQNSKTEHLTLRFVRFYHFISAHddkgYSADYFIQVTDKVQADLFTPIYLNIILPETQKLARPLDR 838
Cdd:pfam03378 237 EPYFKTIFSLLFQRLQNSKTEKFVKRFVIFYHLYSAK----HGADFLIQLIDAIQPGVFGMIYLNVILPETQKLAGPLDR 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 839 KTAVLSFTKTLANSEAFANRYKKGWAFTCEALLKLLELPPLPAS--KDDIIAEHDVEDMAFGVGFTALNTVRPQPRDPWP 916
Cdd:pfam03378 313 KLAAVSYTKLLCESPAFADRYPKGWGFLLQSLLKLLELPPDPAAadEDDIIDEADVDDMGYGVGFTQLNTAGKKERDPFP 392
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2116459302 917 DtGADLKAWVGRYLKEADKKHNGRVSACVQERLGAEARTVLSSY 960
Cdd:pfam03378 393 D-IPDVKQWVGQSLKEASQAHPGRISQIISERLPPEAKQALQKY 435
Cse1 pfam08506
Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the ...
151-521 0e+00

Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the nuclear export of importin alpha. This domain contains HEAT repeats.


Pssm-ID: 430038 [Multi-domain]  Cd Length: 370  Bit Score: 565.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 151 IFKRWRPLFQSNELYTEINHVLNKFGNPFLALFEGLDSFLEENRSNKENLIQGFTQFNLMVKLLFDLSCHDLPPMFEENL 230
Cdd:pfam08506   1 IFKRWRPLFRSDELFLEIKLVLDKFAEPFLTLLQKVDELIEANKNNKASLKILFEVLLLLCKLFYDLNCQDIPEFFEDNM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 231 SGIASLLLKYLTYDNALLHTDDDTEAGQLEFVRAGIFEALTLYVQKYMDVFSSHVGQFVQSSWSFLTTIGQETKYDILVS 310
Cdd:pfam08506  81 KEWMGIFHKYLSYDNPLLETDDDEEATVLEKLKASICELVQLYTLRYEEEFGPMVNDFIQAVWNLLVSTSPQPKYDILVS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 311 KALQFLTSVAGMPEHASVFQAEETLGQIVEKVVLPNVSLRESDEELFEDEPIEFIRRDLEGSDSETRRRAATDFLRRLAE 390
Cdd:pfam08506 161 KALSFLTSVARRPKYAELFNNESVLKQIIEKVVLPNVTLRESDEELFEDDPIEYIRRDLEGSDSDTRRRAATDFLKELKE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 391 QFEGPVTKVVLRYSDHYLAEYSKSPATNWKAKDTAVYLFSAIAAKGvATASHGVTATNPLVSITDFFQKNLAADLVVDES 470
Cdd:pfam08506 241 KFEALVTNVVLEYIQRLLEKYSANPSLNWKAKDTAIYLFTSIAAKG-AVTKSGVTSTNPLVDVVDFFQQQIAPDLMANVN 319
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2116459302 471 AHPILKVDAIKYLYLFRSIITKDQWQEVLPLLVKHLGSPNFVVYTYAAIAV 521
Cdd:pfam08506 320 QHPILKADAIKYIYTFRNQLTKEQLIEIFPLLINFLQSSSYVVYTYAAITI 370
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
4-844 1.62e-157

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 488.17  E-value: 1.62e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302   4 DLGAVAQLLEA-SLDPRQNKQAEATLRQEEQKPGFSLQLLQITASTSYPYNTRLASALCFKNFIKRNWTDEDGNyKLQLD 82
Cdd:COG5657     3 DLPVVKQLDLAqSPDPPSVKCAEERLRQWEKQHGFALKLLSINLSAFNSMSLRWAALIQFKNYIDKHWREENGN-SILPD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302  83 EVATIKRELISLMISVPAGIQSQLGEAVSVIADSDFWERWDTLVDDLVSRLQPKNPAANIGVLQVAHSIFKRWRPLFQSN 162
Cdd:COG5657    82 ENVLIRDELFSLIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLRRLFRSD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 163 ELYTEINHVLNKFGNPFLALFEGLDSFLEenrSNKENLIQGFTQFNLMVKLLFDLSCHDLPPMFEENLSGIASLLLKYLT 242
Cdd:COG5657   162 ALFLEIAPVLLSILCPFLFSSAYFWSMSE---NLDESLLSLFQVCLKLIRRYYDLGFQDIPEFFEDNLDKFMEHFCKLLS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 243 YDNALLHtDDDTEAGQLEFVRAGIFEALTLYVQKYMDVFSSHVGQFVQSSWSFLTTIGQETKYDILVSKALQFLTSV--A 320
Cdd:COG5657   239 YSNPVLQ-KDCLEDCVYFKLKGSICEIFNLYTTKYPEVITYLIYDFVEIVWNLLTTITRPYIRDYLVSKSLTVLINVikY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 321 GMPEHASVFQ--AEETLGQIVEKVVLPNVSLRESDEELFEDEPIEFIRrdlEGSDSETRRRAATDFLRRLAEQFegpvtK 398
Cdd:COG5657   318 PIRKTAEVLSnvSENLINNLVDLLILPNLILREEDLEEWEDDPLEYIR---EQSKTDYEVNVRPCIENELKDLF-----D 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 399 VVLRYSDHYLAEYSKSPATNWKAKDTAVYLFSAIAAKGVatashGVTATNPLVSITDFFQKNLAADLV-VDESAHPILKV 477
Cdd:COG5657   390 VFGRIAVGHELTVIESEATTPNILDEARQLFAAYASFGL-----GVEAVNRMVDFVKFLGSIIYPDLLsPNEIIHLRILR 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 478 DAIKYLYLFRSIITKDQWQEvlpllVKHLGSPNFVVYTYAAIAVERVLYLADSQGQPI----IAPATVTPLAKDLLQHIF 553
Cdd:COG5657   465 SRIAYILTFRNQLDSSELSE-----SKFLASQFFVNYTTACIDAVVLLTTREAYSTIFddwnFSVCSKIGLLENLILLVL 539
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 554 SLIqkdPAPEKVQENEFLMRCAMRVLIVIKEDVVPYTDIVLQHLINITDVISKNPSNPRFYYFHFEAMGAFIRF---AAP 630
Cdd:COG5657   540 SLM---ASPSSLEEREFLLQLISRIIIIDPELIAPLGSEILQLLDNLVEINAKNPSNPQFAHYTFEDIGALVFLksgMCE 616
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 631 ANPEKLEQALYPPFANILQGDVQEFMPYVFQLFAALLEANPSGSLPNYYQNLIAPMLMPVMWESKGNIPALVRLLSSIIP 710
Cdd:COG5657   617 ITIPTLVLALVPEFPVLLSEDATELWSYVLQLLSILPEHFSGDVLPSVVKILRQPSLATELLPTKLEILKSYRLLDNPIL 696
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 711 RGSQfILENQQLVPILGIFQKLLSTKANEGFGFDLLESVVENFPPTALEQYFVSIMQVILTRLQNSKTEHLTLRFVRFYH 790
Cdd:COG5657   697 TTGY-IFKSSGFQPVLGILQYLLGSEPHDALCFLNLTVVETLYLENIYEPYVNLIFVLLLSRLKNSKTERFVIKIIHVFS 775
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2116459302 791 FISAHDDKGYSADYFIQVTDKVQADLFTPIYLNIILPeTQKLARPLDRKTAVLS 844
Cdd:COG5657   776 LVSFKDSLTVGCDNLISKINQTKNILIVQLYGNWILG-FDEIHDSKDRKIHLIG 828
IBN_N pfam03810
Importin-beta N-terminal domain;
24-97 9.87e-12

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 61.10  E-value: 9.87e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2116459302  24 AEATLRQEEQKPGFSLQLLQITASTSYPYNTRLASALCFKNFIKRNWTDEDGnyKLQLDEVATIKRELISLMIS 97
Cdd:pfam03810   1 AEKQLEQFEKSPGFWSKLLQILSNSENPLEVRQLAALYLKNLITRHWEEEKN--SLPPEEKEQIKNNLLNLLGS 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
24-97 1.70e-11

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 60.33  E-value: 1.70e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2116459302   24 AEATLRQEEQKPGFSLQLLQITASTSYPYnTRLASALCFKNFIKRNWtdedgnYKLQLDEVATIKRELISLMIS 97
Cdd:smart00913   1 AEKQLEQFQKSPGFWLLLLEILANSEDQY-VRQLAAITLKNKITRRW------SSLPEEEKEEIKNSLLELLLS 67
 
Name Accession Description Interval E-value
CAS_CSE1 pfam03378
CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are ...
522-960 0e+00

CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein, CSE1. This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation. Like CSE1, it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase), and has been shown to be associated with the microtubule network and the mitotic spindle, as is the protein MEK, which is thought to regulate the intracellular localization (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus, CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors), it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins.


Pssm-ID: 367469  Cd Length: 435  Bit Score: 707.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 522 ERVLYLADSQGQPIIAPATVTPLAKDLLQHIFSLIQKDPApekvQENEFLMRCAMRVLIVIKEDVVPYTDIVLQHLINIT 601
Cdd:pfam03378   1 ERLLTLRDEQGQPIFTSADIAPFAKDLLTHLFAAIEKPGS----QENEYLMKCIMRVLIVIQEAVLPVADVVLQHLTNIL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 602 DVISKNPSNPRFYYFHFEAMGAFIRFAAPANPE---KLEQALYPPFANILQGDVQEFMPYVFQLFAALLEANPSGSLPNY 678
Cdd:pfam03378  77 QEVSKNPSNPRFNHYLFEAIGALIRFACKADPAavsKFEEALFPPFQAILQEDVTEFMPYVFQLLAQLLEANPSGTLPDY 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 679 YQNLIAPMLMPVMWESKGNIPALVRLLSSIIPRGSQFILENQQLVPILGIFQKLLSTKANEGFGFDLLESVVENFPPTAL 758
Cdd:pfam03378 157 YMALFPPLLSPALWERRGNVPALVRLLSAFIPKASQEIVANNKLEPVLGIFQKLIASKANDHQGFYLLESVIENFPPEVL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 759 EQYFVSIMQVILTRLQNSKTEHLTLRFVRFYHFISAHddkgYSADYFIQVTDKVQADLFTPIYLNIILPETQKLARPLDR 838
Cdd:pfam03378 237 EPYFKTIFSLLFQRLQNSKTEKFVKRFVIFYHLYSAK----HGADFLIQLIDAIQPGVFGMIYLNVILPETQKLAGPLDR 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 839 KTAVLSFTKTLANSEAFANRYKKGWAFTCEALLKLLELPPLPAS--KDDIIAEHDVEDMAFGVGFTALNTVRPQPRDPWP 916
Cdd:pfam03378 313 KLAAVSYTKLLCESPAFADRYPKGWGFLLQSLLKLLELPPDPAAadEDDIIDEADVDDMGYGVGFTQLNTAGKKERDPFP 392
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2116459302 917 DtGADLKAWVGRYLKEADKKHNGRVSACVQERLGAEARTVLSSY 960
Cdd:pfam03378 393 D-IPDVKQWVGQSLKEASQAHPGRISQIISERLPPEAKQALQKY 435
Cse1 pfam08506
Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the ...
151-521 0e+00

Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the nuclear export of importin alpha. This domain contains HEAT repeats.


Pssm-ID: 430038 [Multi-domain]  Cd Length: 370  Bit Score: 565.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 151 IFKRWRPLFQSNELYTEINHVLNKFGNPFLALFEGLDSFLEENRSNKENLIQGFTQFNLMVKLLFDLSCHDLPPMFEENL 230
Cdd:pfam08506   1 IFKRWRPLFRSDELFLEIKLVLDKFAEPFLTLLQKVDELIEANKNNKASLKILFEVLLLLCKLFYDLNCQDIPEFFEDNM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 231 SGIASLLLKYLTYDNALLHTDDDTEAGQLEFVRAGIFEALTLYVQKYMDVFSSHVGQFVQSSWSFLTTIGQETKYDILVS 310
Cdd:pfam08506  81 KEWMGIFHKYLSYDNPLLETDDDEEATVLEKLKASICELVQLYTLRYEEEFGPMVNDFIQAVWNLLVSTSPQPKYDILVS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 311 KALQFLTSVAGMPEHASVFQAEETLGQIVEKVVLPNVSLRESDEELFEDEPIEFIRRDLEGSDSETRRRAATDFLRRLAE 390
Cdd:pfam08506 161 KALSFLTSVARRPKYAELFNNESVLKQIIEKVVLPNVTLRESDEELFEDDPIEYIRRDLEGSDSDTRRRAATDFLKELKE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 391 QFEGPVTKVVLRYSDHYLAEYSKSPATNWKAKDTAVYLFSAIAAKGvATASHGVTATNPLVSITDFFQKNLAADLVVDES 470
Cdd:pfam08506 241 KFEALVTNVVLEYIQRLLEKYSANPSLNWKAKDTAIYLFTSIAAKG-AVTKSGVTSTNPLVDVVDFFQQQIAPDLMANVN 319
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2116459302 471 AHPILKVDAIKYLYLFRSIITKDQWQEVLPLLVKHLGSPNFVVYTYAAIAV 521
Cdd:pfam08506 320 QHPILKADAIKYIYTFRNQLTKEQLIEIFPLLINFLQSSSYVVYTYAAITI 370
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
4-844 1.62e-157

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 488.17  E-value: 1.62e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302   4 DLGAVAQLLEA-SLDPRQNKQAEATLRQEEQKPGFSLQLLQITASTSYPYNTRLASALCFKNFIKRNWTDEDGNyKLQLD 82
Cdd:COG5657     3 DLPVVKQLDLAqSPDPPSVKCAEERLRQWEKQHGFALKLLSINLSAFNSMSLRWAALIQFKNYIDKHWREENGN-SILPD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302  83 EVATIKRELISLMISVPAGIQSQLGEAVSVIADSDFWERWDTLVDDLVSRLQPKNPAANIGVLQVAHSIFKRWRPLFQSN 162
Cdd:COG5657    82 ENVLIRDELFSLIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLRRLFRSD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 163 ELYTEINHVLNKFGNPFLALFEGLDSFLEenrSNKENLIQGFTQFNLMVKLLFDLSCHDLPPMFEENLSGIASLLLKYLT 242
Cdd:COG5657   162 ALFLEIAPVLLSILCPFLFSSAYFWSMSE---NLDESLLSLFQVCLKLIRRYYDLGFQDIPEFFEDNLDKFMEHFCKLLS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 243 YDNALLHtDDDTEAGQLEFVRAGIFEALTLYVQKYMDVFSSHVGQFVQSSWSFLTTIGQETKYDILVSKALQFLTSV--A 320
Cdd:COG5657   239 YSNPVLQ-KDCLEDCVYFKLKGSICEIFNLYTTKYPEVITYLIYDFVEIVWNLLTTITRPYIRDYLVSKSLTVLINVikY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 321 GMPEHASVFQ--AEETLGQIVEKVVLPNVSLRESDEELFEDEPIEFIRrdlEGSDSETRRRAATDFLRRLAEQFegpvtK 398
Cdd:COG5657   318 PIRKTAEVLSnvSENLINNLVDLLILPNLILREEDLEEWEDDPLEYIR---EQSKTDYEVNVRPCIENELKDLF-----D 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 399 VVLRYSDHYLAEYSKSPATNWKAKDTAVYLFSAIAAKGVatashGVTATNPLVSITDFFQKNLAADLV-VDESAHPILKV 477
Cdd:COG5657   390 VFGRIAVGHELTVIESEATTPNILDEARQLFAAYASFGL-----GVEAVNRMVDFVKFLGSIIYPDLLsPNEIIHLRILR 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 478 DAIKYLYLFRSIITKDQWQEvlpllVKHLGSPNFVVYTYAAIAVERVLYLADSQGQPI----IAPATVTPLAKDLLQHIF 553
Cdd:COG5657   465 SRIAYILTFRNQLDSSELSE-----SKFLASQFFVNYTTACIDAVVLLTTREAYSTIFddwnFSVCSKIGLLENLILLVL 539
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 554 SLIqkdPAPEKVQENEFLMRCAMRVLIVIKEDVVPYTDIVLQHLINITDVISKNPSNPRFYYFHFEAMGAFIRF---AAP 630
Cdd:COG5657   540 SLM---ASPSSLEEREFLLQLISRIIIIDPELIAPLGSEILQLLDNLVEINAKNPSNPQFAHYTFEDIGALVFLksgMCE 616
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 631 ANPEKLEQALYPPFANILQGDVQEFMPYVFQLFAALLEANPSGSLPNYYQNLIAPMLMPVMWESKGNIPALVRLLSSIIP 710
Cdd:COG5657   617 ITIPTLVLALVPEFPVLLSEDATELWSYVLQLLSILPEHFSGDVLPSVVKILRQPSLATELLPTKLEILKSYRLLDNPIL 696
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 711 RGSQfILENQQLVPILGIFQKLLSTKANEGFGFDLLESVVENFPPTALEQYFVSIMQVILTRLQNSKTEHLTLRFVRFYH 790
Cdd:COG5657   697 TTGY-IFKSSGFQPVLGILQYLLGSEPHDALCFLNLTVVETLYLENIYEPYVNLIFVLLLSRLKNSKTERFVIKIIHVFS 775
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2116459302 791 FISAHDDKGYSADYFIQVTDKVQADLFTPIYLNIILPeTQKLARPLDRKTAVLS 844
Cdd:COG5657   776 LVSFKDSLTVGCDNLISKINQTKNILIVQLYGNWILG-FDEIHDSKDRKIHLIG 828
SXM1 COG5656
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, ...
7-771 1.09e-15

Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227943 [Multi-domain]  Cd Length: 970  Bit Score: 82.21  E-value: 1.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302   7 AVAQLLEASL--DPRQNKQAEATLRQEEQKPGFSLQLLQITASTSYPYNTRLASALCFKNFIKRNWTDEDgNYKLQLDEV 84
Cdd:COG5656     4 ELLQCFLQTLdaDAGKRTIAEAMLKDLEKQPGFVMALLHICSKDEGDLNVKLSAAIYFKNKIIRSWSSKR-DDGIKADEK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302  85 ATIKRELISLMISV----PAGIQSQLGEAVSVIADSDFWERWDTLVDDLVSRLQPKNPAANIGVLQVAHSIFK--RWRpl 158
Cdd:COG5656    83 SEAKKYLIENILDVflysPEVTRTALNAILVNIFSEDKPSDLWGLFPKAANLLRSSEANHVYTGLLCLEELFKayRWK-- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 159 fqsnelyteiNHVLNKFGNPF-LALF---EGLDSFLEEnrsnkenliQGFTQFNLMVKLL---FDLSC-HDLPPMFE--E 228
Cdd:COG5656   161 ----------YNDEQVDILMLiTALFpilEKVGGNLES---------QGNYGSVETLMLIlksFKSVCyYSLPDFLSaiE 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 229 NLSGIASLLLKYLTYD--NALLHTD-DDTEAGQLEFVRAGIFEALTLYVQKYMDVFSS-HVGQFVQSSWSFLTTIGQETK 304
Cdd:COG5656   222 TFSSWFQLSLRILQKPlpNEVLSLDpEVRSLSKWVKCKKWAAYNLYRSFQRYIKKSYKkSYLSFYITFMTRVPMILATFF 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 305 YDI---------LVSKALQFLTSVAGMPEHASVFQA--EETLGQIVEKVVLPNVSLRESDEELFEDEPIEFIRRDLEGSD 373
Cdd:COG5656   302 KQIeewgqgqlwLSDIELYFIDFFVELCVDADQTWRlmEPHLQYIISGVIFPLLCLSEEEEELFENDPDEYIRRYYDFFD 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 374 SETRRRAATDFL------RRLAEQFEGpvtkvVLRYSDHYLAEYSKSPAT--NWKAKDTAVYLFSAIaakgvataSHGVT 445
Cdd:COG5656   382 NGLSPDLAALFFliisksKRKEETFQG-----ILSFLLSILGQSAATPSNidNARQAEGALRLLASI--------KSFIT 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 446 ATNPLVSITDFFQKNLAADLVVDESAhpILKVDAIKYLYLFrSIITKDQWQ--EVLPLLVKHLGSPNFVVYTYAAIAVer 523
Cdd:COG5656   449 KMSPAANVMEYFIVNHVIPAFRSNYG--FLKSRACEFISTI-EEDFKDNGIllEAYENTHNCLKNNHLPVMIEAALAL-- 523
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 524 vlyladsqgQPIIAPATVTPLakdLLQHIFSLIQKDPAPEKVQENEFLMRCAMRVLIVIKEDVVPYTDIVLQHLIN---- 599
Cdd:COG5656   524 ---------QFFIFNEQSHEK---FSAHVPETMEKLLSLSNTFEIDPLSMVMESFVEYFSEELSPFAPELAGSLVRqflk 591
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 600 ITDVISKNPsnPRFYYFHFEAMGAFIRF------------AAPANPEKLEQALYPPFANILQGDVQEFMPYVFQLFAALL 667
Cdd:COG5656   592 IAQSLLENS--SDTSSVVDDKQMAASGIlrtiesmilsleNRPLVLKYLEVSLYPVISFILKNEISDFYQEALDILDGYT 669
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116459302 668 eanpsgslpnYYQNLIAPmLMPVMWESKGNIP----------ALVRLLSSIIPRGSQFILENQQLV-PILGIFQKLLSTK 736
Cdd:COG5656   670 ----------FMSKEIEP-IMWGIFELLLNLLideitavyseEVADALDNFITYGKTEFMDAGIYGsICSEISKLCLCSE 738
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|..
gi 2116459302 737 ANEGF----GFDLLESVVENFPPTALEQY---FVSIMQVILT 771
Cdd:COG5656   739 ENFLEdfigVCRIIESLILNIRDELLSQYlplFISVAGSGLK 780
IBN_N pfam03810
Importin-beta N-terminal domain;
24-97 9.87e-12

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 61.10  E-value: 9.87e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2116459302  24 AEATLRQEEQKPGFSLQLLQITASTSYPYNTRLASALCFKNFIKRNWTDEDGnyKLQLDEVATIKRELISLMIS 97
Cdd:pfam03810   1 AEKQLEQFEKSPGFWSKLLQILSNSENPLEVRQLAALYLKNLITRHWEEEKN--SLPPEEKEQIKNNLLNLLGS 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
24-97 1.70e-11

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 60.33  E-value: 1.70e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2116459302   24 AEATLRQEEQKPGFSLQLLQITASTSYPYnTRLASALCFKNFIKRNWtdedgnYKLQLDEVATIKRELISLMIS 97
Cdd:smart00913   1 AEKQLEQFQKSPGFWLLLLEILANSEDQY-VRQLAAITLKNKITRRW------SSLPEEEKEEIKNSLLELLLS 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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