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Conserved domains on  [gi|2222389694|gb|KAI2516622|]
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MPL proto-oncogene, thrombopoietin receptor [Homo sapiens]

Protein Classification

EpoR_lig-bind and FN3 domain-containing protein( domain architecture ID 10557304)

EpoR_lig-bind and FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 25-128 1.03e-41

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


:

Pssm-ID: 401127  Cd Length: 104  Bit Score: 146.41  E-value: 1.03e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222389694  25 SQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGT-YQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQeEVRL 103
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTtYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKN-DVSL 79

                          90       100
                  ....*....|....*....|....*
gi 2222389694 104 FFPLHLWVKNVFLNQTRTQRVLFVD 128
Cdd:pfam09067  80 FVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 395-485 4.80e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 4.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222389694 395 NLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTL--ELRPRSRYRLQLRARlngptYQG 472
Cdd:cd00063     6 NLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTltGLKPGTEYEFRVRAV-----NGG 80

                          90
                  ....*....|...
gi 2222389694 473 PWSSWSDPTRVET 485
Cdd:cd00063    81 GESPPSESVTVTT 93
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 25-128 1.03e-41

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 146.41  E-value: 1.03e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222389694  25 SQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGT-YQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQeEVRL 103
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTtYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKN-DVSL 79

                          90       100
                  ....*....|....*....|....*
gi 2222389694 104 FFPLHLWVKNVFLNQTRTQRVLFVD 128
Cdd:pfam09067  80 FVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 395-485 4.80e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 4.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222389694 395 NLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTL--ELRPRSRYRLQLRARlngptYQG 472
Cdd:cd00063     6 NLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTltGLKPGTEYEFRVRAV-----NGG 80

                          90
                  ....*....|...
gi 2222389694 473 PWSSWSDPTRVET 485
Cdd:cd00063    81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
395-475 9.39e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 9.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222389694 395 NLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQD-WKVLEPPLGARGGTLE-LRPRSRYRLQLRARlNGpTYQG 472
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTgLKPGTEYEVRVQAV-NG-GGEG 82


                  ...
gi 2222389694 473 PWS 475
Cdd:pfam00041  83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 392-464 3.69e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 3.69e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2222389694  392 PTPNLHWREISSGHLELEWQHPSSWaaQETCYQLRYT---GEGHQDWKVLEPPLGARGGTLE-LRPRSRYRLQLRAR 464
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDD--GITGYIVGYRveyREEGSEWKEVNVTPSSTSYTLTgLKPGTEYEFRVRAV 77
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 25-128 1.03e-41

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 146.41  E-value: 1.03e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222389694  25 SQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGT-YQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQeEVRL 103
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTtYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKN-DVSL 79

                          90       100
                  ....*....|....*....|....*
gi 2222389694 104 FFPLHLWVKNVFLNQTRTQRVLFVD 128
Cdd:pfam09067  80 FVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 395-485 4.80e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 4.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222389694 395 NLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTL--ELRPRSRYRLQLRARlngptYQG 472
Cdd:cd00063     6 NLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTltGLKPGTEYEFRVRAV-----NGG 80

                          90
                  ....*....|...
gi 2222389694 473 PWSSWSDPTRVET 485
Cdd:cd00063    81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
395-475 9.39e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 9.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222389694 395 NLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQD-WKVLEPPLGARGGTLE-LRPRSRYRLQLRARlNGpTYQG 472
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTgLKPGTEYEVRVQAV-NG-GGEG 82


                  ...
gi 2222389694 473 PWS 475
Cdd:pfam00041  83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 392-464 3.69e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 3.69e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2222389694  392 PTPNLHWREISSGHLELEWQHPSSWaaQETCYQLRYT---GEGHQDWKVLEPPLGARGGTLE-LRPRSRYRLQLRAR 464
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDD--GITGYIVGYRveyREEGSEWKEVNVTPSSTSYTLTgLKPGTEYEFRVRAV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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