NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2247850870|gb|KAI4062754|]
View 

tubulin epsilon and delta complex 1, partial [Homo sapiens]

Protein Classification

DUF4509 domain-containing protein( domain architecture ID 10633163)

DUF4509 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TEDC1 pfam14970
Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and ...
 49-221 1.30e-71

Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and delta complex protein 1 (TEDC1). This complex is required for centriole maintenance and it is a component of several ciliary structures. It acts as a positive regulator of hedgehog signalling, which play key roles in embryonic development and in cancers. Additionally, this protein may play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F.


:

Pssm-ID: 464414  Cd Length: 161  Bit Score: 218.36  E-value: 1.30e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2247850870  49 GYPRLALAQLPEDGSQGSRELLLALSWLLARGPVPEQMLAQARVPLGDEMTVCQCEALaspgPPAPhmeaegpvDVRHVQ 128
Cdd:pfam14970   1 GYPRLEFYQLPEDGSFGSRELLLALGWLLARGNLLEKLLALKRLPLGDESSVCECESS----PSAP--------DIRYLQ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2247850870 129 WLMGKLRFRWRQLVSSQQEQCALLSKIHLYTRGCHSDQSLSHLSVTEAEMLRDPEGGQQLLRTLERENQRLEAVLAWRRS 208
Cdd:pfam14970  69 WLNGKLRFQWRSLYSLQQERCKLLHKIHSYTQGCSGLPSLGHLSVSETALLRDPELLKQLLQLLEKENSRLEALLEWKRK 148

                         170
                  ....*....|...
gi 2247850870 209 ELVFWRWMDTVLG 221
Cdd:pfam14970 149 EHVFWQWMESVLD 161
 
Name Accession Description Interval E-value
TEDC1 pfam14970
Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and ...
 49-221 1.30e-71

Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and delta complex protein 1 (TEDC1). This complex is required for centriole maintenance and it is a component of several ciliary structures. It acts as a positive regulator of hedgehog signalling, which play key roles in embryonic development and in cancers. Additionally, this protein may play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F.


Pssm-ID: 464414  Cd Length: 161  Bit Score: 218.36  E-value: 1.30e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2247850870  49 GYPRLALAQLPEDGSQGSRELLLALSWLLARGPVPEQMLAQARVPLGDEMTVCQCEALaspgPPAPhmeaegpvDVRHVQ 128
Cdd:pfam14970   1 GYPRLEFYQLPEDGSFGSRELLLALGWLLARGNLLEKLLALKRLPLGDESSVCECESS----PSAP--------DIRYLQ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2247850870 129 WLMGKLRFRWRQLVSSQQEQCALLSKIHLYTRGCHSDQSLSHLSVTEAEMLRDPEGGQQLLRTLERENQRLEAVLAWRRS 208
Cdd:pfam14970  69 WLNGKLRFQWRSLYSLQQERCKLLHKIHSYTQGCSGLPSLGHLSVSETALLRDPELLKQLLQLLEKENSRLEALLEWKRK 148

                         170
                  ....*....|...
gi 2247850870 209 ELVFWRWMDTVLG 221
Cdd:pfam14970 149 EHVFWQWMESVLD 161
 
Name Accession Description Interval E-value
TEDC1 pfam14970
Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and ...
 49-221 1.30e-71

Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and delta complex protein 1 (TEDC1). This complex is required for centriole maintenance and it is a component of several ciliary structures. It acts as a positive regulator of hedgehog signalling, which play key roles in embryonic development and in cancers. Additionally, this protein may play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F.


Pssm-ID: 464414  Cd Length: 161  Bit Score: 218.36  E-value: 1.30e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2247850870  49 GYPRLALAQLPEDGSQGSRELLLALSWLLARGPVPEQMLAQARVPLGDEMTVCQCEALaspgPPAPhmeaegpvDVRHVQ 128
Cdd:pfam14970   1 GYPRLEFYQLPEDGSFGSRELLLALGWLLARGNLLEKLLALKRLPLGDESSVCECESS----PSAP--------DIRYLQ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2247850870 129 WLMGKLRFRWRQLVSSQQEQCALLSKIHLYTRGCHSDQSLSHLSVTEAEMLRDPEGGQQLLRTLERENQRLEAVLAWRRS 208
Cdd:pfam14970  69 WLNGKLRFQWRSLYSLQQERCKLLHKIHSYTQGCSGLPSLGHLSVSETALLRDPELLKQLLQLLEKENSRLEALLEWKRK 148

                         170
                  ....*....|...
gi 2247850870 209 ELVFWRWMDTVLG 221
Cdd:pfam14970 149 EHVFWQWMESVLD 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH