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Conserved domains on  [gi|2425517891|gb|KAJ3615395|]
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hypothetical protein NHX12_016944 [Muraenolepis orangiensis]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10456837)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  15581578|10940244|9175471|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 88-171 8.44e-16

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 70.07  E-value: 8.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  88 SFPVDTQVAYILSLGVVKEFRKHGIGSLLLDSLKEHIsttAQDHCKAVYLHVLTTNINAIHFYQNRDFRQHHYLPYYYSI 167
Cdd:COG0456     6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERA---RERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGD 82


                  ....
gi 2425517891 168 RGVL 171
Cdd:COG0456    83 DALV 86
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
15-156 8.71e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 49.70  E-value: 8.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  15 LRLLCHDDIDSVKLLCGDWFPIEYPDSWYQDITSNKKF-FSLAATFKGGIMGMIVAEIkgrtkvhkedgdilaSSFPVDT 93
Cdd:COG3153     1 IRPATPEDAEAIAALLRAAFGPGREAELVDRLREDPAAgLSLVAEDDGEIVGHVALSP---------------VDIDGEG 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2425517891  94 QVAYILSLGVVKEFRKHGIGSLLLDSLKEHistTAQDHCKAVYLHvltTNINAIHFYQNRDFR 156
Cdd:COG3153    66 PALLLGPLAVDPEYRGQGIGRALMRAALEA---ARERGARAVVLL---GDPSLLPFYERFGFR 122
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 88-171 8.44e-16

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 70.07  E-value: 8.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  88 SFPVDTQVAYILSLGVVKEFRKHGIGSLLLDSLKEHIsttAQDHCKAVYLHVLTTNINAIHFYQNRDFRQHHYLPYYYSI 167
Cdd:COG0456     6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERA---RERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGD 82


                  ....
gi 2425517891 168 RGVL 171
Cdd:COG0456    83 DALV 86
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 77-155 2.02e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 61.76  E-value: 2.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  77 VHKEDGDILA----SSFPVDTQVAYILSLGVVKEFRKHGIGSLLLDSLKEHIsttAQDHCKAVYLHVLTTNINAIHFYQN 152
Cdd:pfam00583  37 VAEEDGELVGfaslSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWA---RERGCERIFLEVAADNLAAIALYEK 113


                  ...
gi 2425517891 153 RDF 155
Cdd:pfam00583 114 LGF 116
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
15-156 8.71e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 49.70  E-value: 8.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  15 LRLLCHDDIDSVKLLCGDWFPIEYPDSWYQDITSNKKF-FSLAATFKGGIMGMIVAEIkgrtkvhkedgdilaSSFPVDT 93
Cdd:COG3153     1 IRPATPEDAEAIAALLRAAFGPGREAELVDRLREDPAAgLSLVAEDDGEIVGHVALSP---------------VDIDGEG 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2425517891  94 QVAYILSLGVVKEFRKHGIGSLLLDSLKEHistTAQDHCKAVYLHvltTNINAIHFYQNRDFR 156
Cdd:COG3153    66 PALLLGPLAVDPEYRGQGIGRALMRAALEA---ARERGARAVVLL---GDPSLLPFYERFGFR 122
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 84-138 5.55e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 5.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2425517891  84 ILASSFPVDTQVAYILSLGVVKEFRKHGIGSLLLDSLKEHIsttAQDHCKAVYLH 138
Cdd:cd04301    14 ASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEA---RERGAKRLRLE 65
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 88-171 8.44e-16

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 70.07  E-value: 8.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  88 SFPVDTQVAYILSLGVVKEFRKHGIGSLLLDSLKEHIsttAQDHCKAVYLHVLTTNINAIHFYQNRDFRQHHYLPYYYSI 167
Cdd:COG0456     6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERA---RERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGD 82


                  ....
gi 2425517891 168 RGVL 171
Cdd:COG0456    83 DALV 86
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 77-155 2.02e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 61.76  E-value: 2.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  77 VHKEDGDILA----SSFPVDTQVAYILSLGVVKEFRKHGIGSLLLDSLKEHIsttAQDHCKAVYLHVLTTNINAIHFYQN 152
Cdd:pfam00583  37 VAEEDGELVGfaslSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWA---RERGCERIFLEVAADNLAAIALYEK 113


                  ...
gi 2425517891 153 RDF 155
Cdd:pfam00583 114 LGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
67-173 3.36e-10

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 56.93  E-value: 3.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  67 IVAEikgrtkvhkEDGDILA-------SSFPVDTQVAYIlSLGVVKEFRKHGIGSLLLDSLKEHistTAQDHCKAVYLHV 139
Cdd:COG1247    55 LVAE---------EDGEVVGfaslgpfRPRPAYRGTAEE-SIYVDPDARGRGIGRALLEALIER---ARARGYRRLVAVV 121

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2425517891 140 LTTNINAIHFYQNRDFRQHHYLPYYYSIRGVLKD 173
Cdd:COG1247   122 LADNEASIALYEKLGFEEVGTLPEVGFKFGRWLD 155
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 67-163 1.21e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 54.61  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  67 IVAEIKGRTKVHKEDGDILASS--FPVDTQVAYILSLGVVKEFRKHGIGSLLLDSLKEHisttAQDH-CKAVYLHvltTN 143
Cdd:COG1246    22 ALEEEIGEFWVAEEDGEIVGCAalHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAE----ARELgLKRLFLL---TT 94

                          90       100
                  ....*....|....*....|..
gi 2425517891 144 INAIHFYQNRDFRQ--HHYLPY 163
Cdd:COG1246    95 SAAIHFYEKLGFEEidKEDLPY 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 92-157 7.04e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 48.60  E-value: 7.04e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2425517891  92 DTQVAYILSLGVVKEFRKHGIGSLLLDSLKEHIsttaqdHCKAVYLHVLTTNINAIHFYQNRDFRQ 157
Cdd:pfam13508  25 DEGALAELRLAVHPEYRGQGIGRALLEAAEAAA------KEGGIKLLELETTNRAAAFYEKLGFEE 84
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
86-164 8.27e-08

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 48.37  E-value: 8.27e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2425517891  86 ASSFPVDTQVAYILSLGVVKEFRKHGIGSLLLDSLKEHIsttAQDHCKAVYLHVLTTNINAIHFYQNRDFRQHHYLPYY 164
Cdd:COG3393     6 AGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREA---LARGARTPFLYVDADNPAARRLYERLGFRPVGEYATV 81
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
15-156 8.71e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 49.70  E-value: 8.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  15 LRLLCHDDIDSVKLLCGDWFPIEYPDSWYQDITSNKKF-FSLAATFKGGIMGMIVAEIkgrtkvhkedgdilaSSFPVDT 93
Cdd:COG3153     1 IRPATPEDAEAIAALLRAAFGPGREAELVDRLREDPAAgLSLVAEDDGEIVGHVALSP---------------VDIDGEG 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2425517891  94 QVAYILSLGVVKEFRKHGIGSLLLDSLKEHistTAQDHCKAVYLHvltTNINAIHFYQNRDFR 156
Cdd:COG3153    66 PALLLGPLAVDPEYRGQGIGRALMRAALEA---ARERGARAVVLL---GDPSLLPFYERFGFR 122
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 48-164 1.32e-06

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 46.20  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  48 SNKKFFSLAATFKGGIMGMIvAEIKGRTKVHKEDGDIL---ASSFPVDTQVAYILSLGVVKEFRKHGIGSLLLDSLkehI 124
Cdd:COG0454     9 EDINFILLIEALDAELKAME-GSLAGAEFIAVDDKGEPigfAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEAL---L 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2425517891 125 STTAQDHCKAVYLHVLTTNINAIHFYQNRDFRQHHYLPYY 164
Cdd:COG0454    85 EWARERGCTALELDTLDGNPAAIRFYERLGFKEIERYVAY 124
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 84-138 5.55e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 5.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2425517891  84 ILASSFPVDTQVAYILSLGVVKEFRKHGIGSLLLDSLKEHIsttAQDHCKAVYLH 138
Cdd:cd04301    14 ASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEA---RERGAKRLRLE 65
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 94-156 1.74e-04

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 39.24  E-value: 1.74e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2425517891  94 QVAYILSLGVVKEFRKHGIGSLLLDSLKEHISTTAQDhckaVYLHVLTTNINAIHFYQNRDFR 156
Cdd:pfam08445  20 PGGELGALQTLPEHRRRGLGSRLVAALARGIAERGIT----PFAVVVAGNTPSRRLYEKLGFR 78
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
80-158 6.86e-04

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 38.63  E-value: 6.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  80 EDGDILASS--FPVDTQVAYIlslG---VVKEFRKHGIGSLLLDSLKEHIsttAQDHCKAVYLHVLTTninAIHFYQNRD 154
Cdd:COG2153    41 DDGELVATArlLPPGDGEAKI---GrvaVLPEYRGQGLGRALMEAAIEEA---RERGARRIVLSAQAH---AVGFYEKLG 111


                  ....
gi 2425517891 155 FRQH 158
Cdd:COG2153   112 FVPV 115
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 33-158 4.96e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 36.09  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2425517891  33 WFPIEYPDSWYQDITSNKKFFsLAATFKGGIMGMIvaEIKGRTKVHkedgdilassfpvdtqvayilSLGVVKEFRKHGI 112
Cdd:pfam13673  13 FYEFISPEALRERIDQGEYFF-FVAFEGGQIVGVI--ALRDRGHIS---------------------LLFVDPDYQGQGI 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2425517891 113 GSLLLDSLKEHISttaQDHCKAVYLhVLTTNINAIHFYQNRDFRQH 158
Cdd:pfam13673  69 GKALLEAVEDYAE---KDGIKLSEL-TVNASPYAVPFYEKLGFRAT 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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