BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  34 YTDCELVLSDGHLRASRMVLGMASSFFENIFQATinqpvSGTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDMSSFL 113
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKET-----PPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLL 75

                         90
                 ....*....|
gi 668444266 114 DACYLLHIRG 123
Cdd:cd18315   76 KLAELLQIKG 85

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                          10        20        30
                  ....*....|....*....|....*....|
gi 668444266  404 IEAAQKCLSGSMSLSEAARKYSLPKTTIWR 433
Cdd:pfam05225   6 AEALEAVRNGQMSIRKAARIYGIPYSTLWR 35

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  34 YTDCELVLSDGHLRASRMVLGMASSFFENIFQATinqpvSGTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDMSSFL 113
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKET-----PPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLL 75

                         90
                 ....*....|
gi 668444266 114 DACYLLHIRG 123
Cdd:cd18315   76 KLAELLQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266    36 DCELVLSDGHLRASRMVLGMASSFFENIFqatiNQPVSGTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDMSSFLDA 115
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALF----SSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                   ....*....
gi 668444266   116 CYLLHIRGV 124
Cdd:smart00225  77 ADYLQIPGL 85

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                          10        20        30
                  ....*....|....*....|....*....|
gi 668444266  404 IEAAQKCLSGSMSLSEAARKYSLPKTTIWR 433
Cdd:pfam05225   6 AEALEAVRNGQMSIRKAARIYGIPYSTLWR 35

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  34 YTDCELVLSDGHLRASRMVLGMASSFFENIFQATinqpvSGTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDMSSFL 113
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKET-----PPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLL 75

                         90
                 ....*....|
gi 668444266 114 DACYLLHIRG 123
Cdd:cd18315   76 KLAELLQIKG 85

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266   30 EHLQYTDCELVLSDGHLRASRMVLGMASSFFENIFQATINQPvsgtDLLKVLIPDVTVSSMQYVLQFIYTGEVkLRAEDM 109
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESES----SVSEITLDDVSPEDFEALLEFMYTGKL-ISEENV 80

                          90
                  ....*....|....*
gi 668444266  110 SSFLDACYLLHIRGV 124
Cdd:pfam00651  81 DDLLAAADKLQIPSL 95

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  27 GIYEHLQYTDCELVLSDGH-LRASRMVLGMASSFFENIFqatinqpvsGTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLR 105
Cdd:cd18299    5 NLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLF---------LMMTVVTLDSDITPEAFRRVLEFLYTGVLDEN 75

                 ...
gi 668444266 106 AED 108
Cdd:cd18299   76 EDD 78

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                          10        20        30
                  ....*....|....*....|....*....|
gi 668444266  404 IEAAQKCLSGSMSLSEAARKYSLPKTTIWR 433
Cdd:pfam05225   6 AEALEAVRNGQMSIRKAARIYGIPYSTLWR 35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  30 EHLQYTDCELVLSDGHLRASRMVLGMASSFFENIFqaTINQPVSGTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDM 109
Cdd:cd18245   10 EEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKL--NYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNI 87

                         90
                 ....*....|
gi 668444266 110 SSFLDACYLL 119
Cdd:cd18245   88 QDIVQAADLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  22 LRIYTGIYEHLQYTDCELVLSDGHLRASRMVLGMASSFFENIFQATINQPVSGTDLLKVLIPDVtvssMQYVLQFIYTGE 101
Cdd:cd18237    9 MGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDI----IELLVEFAYTAR 84

                         90
                 ....*....|....
gi 668444266 102 VKLRAEDMSSFLDA 115
Cdd:cd18237   85 ISVNSNNVQSLLDA 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  18 GEHMLRIYTGIYEHLQYTDCELVLSDGHLRASRMVLGMASSFFENIFQATINQPVSGTdllkVLIPDVTVSSMQYVLQFI 97
Cdd:cd18271    8 GQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGS----VTISNLSPKAVKAFLDYA 83

                         90       100
                 ....*....|....*....|....*...
gi 668444266  98 YTGEVKLRAED------MSSFLDACYLL 119
Cdd:cd18271   84 YTGKAEITDDNvemffqMSSFLQVSLLS 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  33 QYTDCELVLSDGHLRASRMVLGMASSFFENIFQATINQpvsgTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDMSSF 112
Cdd:cd18240   16 KLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNE----TEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEEL 91

                         90
                 ....*....|..
gi 668444266 113 LDACYLLHIRGV 124
Cdd:cd18240   92 LPAADQFNIMGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  20 HMLRIYTGIYE---HLQYTDCELVLSDGHLRASRMVLGMASSFFENIFQATINQpvSGTDllKVLIPDVTVSSMQYVLQF 96
Cdd:cd18250    4 HALHLLRGLSElraERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRE--SRAD--RVVLHGVSAEILGLLLDF 79

                         90       100
                 ....*....|....*....|....*...
gi 668444266  97 IYTGEVKLRAEDMSSFLDACYLLHIRGV 124
Cdd:cd18250   80 SYTGRVTVTQDNVEALLRAADLFQFPSV 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  33 QYTDCELVLSDGHLRASRMVLGMASSFFENIFqatiNQPVSGTdllkVLIPDVTVSSMQYVLQFIYTGEVKLRAEDMSSF 112
Cdd:cd18232   17 QYCDATLDVGGRVFKAHWSVLACCSHFFQSLY----GDGTSGS----VVLPESFAEVFGLLLDFFYTGELALTRENRDRV 88

                 ....*....
gi 668444266 113 LDACYLLHI 121
Cdd:cd18232   89 LLAAKELRV 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  30 EHLQYTDCELVLSDGHLRASRMVLGMASSFFENIFQATINQPVSGTDLLKvlipDVTVSSMQYVLQFIYTGEVKLRAEDM 109
Cdd:cd18272   28 EDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELK----DVSESVFQLLVDYIYHGTVKLRVEEL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  36 DCELVLSDGHLRASRMVLGMASSFFENIFQATINQpvsgTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDMSSFLDA 115
Cdd:cd18251   25 DVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLRE----MQQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTA 100

                 ....*....
gi 668444266 116 CYLLHIRGV 124
Cdd:cd18251  101 ACQLQIPEV 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  36 DCELVLSDGHLRASRMVLGMASSFFENIFQATINQpvsgTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDMSSFLDA 115
Cdd:cd18324   25 DCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDK----RDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAA 100

                 ....*.
gi 668444266 116 CYLLHI 121
Cdd:cd18324  101 ASYLHM 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  30 EHLQYTDCELVLSDGHLRASRMVLGMASSFFENIFQATINQPVSGTDLLKVLIPDVtvssMQYVLQFIYTGEVKLRAEDM 109
Cdd:cd18340   23 DHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDV----MGKILHYIYTSEIEITEQNV 98

                         90
                 ....*....|..
gi 668444266 110 SSFLDACYLLHI 121
Cdd:cd18340   99 QDIFAAANMFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  36 DCELVLSDGHLRASRMVLGMASSFFENIFQatiNQPVSGTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDMSSFLDA 115
Cdd:cd18956   25 DCTVLVGDARFPAHRAVLAACSVYFHLFYR---DRPAGGRDTVRLNGDIVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAA 101

                 ....*.
gi 668444266 116 CYLLHI 121
Cdd:cd18956  102 ASYLHM 107

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  34 YTDCELVLsDGH-LRASRMVLGMASSFFENIFQATInqPVSGTdlLKVLIPDvTVSSMQ---YVLQFIYTGEVKLRAEDM 109
Cdd:cd18309   20 FCDITLLL-DGHpIPAHKAILAARCSYFEAMFRSFM--PEDNT--VNISIGE-MVPSRQafdSLLRYIYYGDVTMPPEDS 93

                 ....*...
gi 668444266 110 SSFLDACY 117
Cdd:cd18309   94 LYLFSAPY 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  33 QYTDCELVLSDGHLRASRMVLGMASSFFENIFQATINQpvSGTDllKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDMSSF 112
Cdd:cd18287   21 EYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRE--SQQS--EIELKDTNAEAFKALLKYIYTGRLTLTDLKEDVL 96

                 ....*...
gi 668444266 113 LDACYLLH 120
Cdd:cd18287   97 LDVLGLAH 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  30 EHLQYTDCELVLSDGHLRASRMVLGMASSFFENIFQATINQpvSGTDLlkVLIPDVTVSSMQYVLQFIYTGEVKLRAEDM 109
Cdd:cd18256   16 GQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSE--SSKDV--VQIHGVEPDIFHILLDFIYTGVVEVTVSNV 91

                         90
                 ....*....|....*
gi 668444266 110 SSFLDACYLLHIRGV 124
Cdd:cd18256   92 QELLVAADMLQLTEV 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  37 CELVL--SDGHLRASRMVLGMASSFFENIFQATINQpvsgTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDMSSFLD 114
Cdd:cd18246   40 CDIVLhvGTKEIKAHKVVLASCSPYFHAMFTNEMSE----SRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLP 115

                         90
                 ....*....|
gi 668444266 115 ACYLLHIRGV 124
Cdd:cd18246  116 AASLLQLNGV 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 668444266  36 DCELVLSDGHLRASRMVLGMASSFFenifQATINQPVSGtDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAEDM 109
Cdd:cd18955    3 DVTIVVEDQRFRAHRAVLAACSDYF----LSRVVGQTDG-DLVITLPEEVTVKGFEPLLQFAYTAKLLLSKENV 71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  20 HMLRIYTG-IYEHLQYTDCELVLSDGHLRASRMVLGMASSFFENIFQATINQPVSGTDLLKVLIPDVtvssMQYVLQFIY 98
Cdd:cd18344    8 HMLTDDLGeLWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQV----FKEMMGFIY 83

                         90       100
                 ....*....|....*....|.
gi 668444266  99 TGevklRAEDMSSFLDACYLL 119
Cdd:cd18344   84 TG----KAPHLHSHSMACDVL 100

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 668444266  29 YEHLQYTDCELVLSDGHLRASRMVLGMASSFFENIFQATINQpvsgTDLLKVLIPDVTVSSMQYVLQFIYTGEVKLRAE 107
Cdd:cd18314    1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIE----SNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEE 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668444266  26 TGIYEHLQYTDCELVLSDGH-----------LRASRMVLGMASSFFENIFqatiNQPVSGTDLlKVLIPDVTVSSMQYVL 94
Cdd:cd18281    7 TTVKERFAFLFNNETLSDVHfivgkgdneqrIPAHKFVLSIGSAVFDAMF----NGGMATTSA-EIELPDVEPAAFLALL 81

                         90
                 ....*....|....*....
gi 668444266  95 QFIYTGEVKLRAEDMSSFL 113
Cdd:cd18281   82 RFLYSDEVQIGPETVMTTL 100