|
Name |
Accession |
Description |
Interval |
E-value |
| ASKHA_NBD_ROK_BsFRK-like |
cd24067 |
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ... |
2-283 |
1.37e-166 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466917 [Multi-domain] Cd Length: 285 Bit Score: 463.55 E-value: 1.37e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 2 LGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQYFRQF--SLQAIGIGSFGPVDNDKTSQTYGTITATPKA 79
Cdd:cd24067 1 FGGIEAGGTKFVCAVGTGDGNIIERTEFPTTTPEETLQAVIDFFREQeePIDAIGIASFGPIDLNPTSPTYGYITTTPKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 80 GWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRH 159
Cdd:cd24067 81 GWRNFDILGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVHGLLHPEMGHIRVPRH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 160 PDDV-YRGKCPYHGDCFEGLASGPAIEARWGKKAADLSDLTQVWELEGYYIAQALAQYILILAPKKIILGGGVMQQKQVF 238
Cdd:cd24067 161 PDDDgFPGVCPFHGDCLEGLASGPAIAARWGIPAEELPDDHPAWDLEAYYLAQACANLTLTLSPERIVLGGGVMQRPGLF 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 671705950 239 PYIYQYVPKIMNSYFNFSELSENISDYIVPPHLGSNAGIIGTLVL 283
Cdd:cd24067 241 PRIREKFRKLLNGYLEVPRLLPDIDEYIVPPALGNDAGILGALAL 285
|
|
| ROK |
pfam00480 |
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
3-286 |
1.65e-83 |
|
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.
Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 253.03 E-value: 1.65e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 3 GGIEAGGTKFVCAVGREDGTIIDRIEF--PTKMPDETIEKVIQYF-----RQF-SLQAIGIGSFGPVDNDktsqtYGTIT 74
Cdd:pfam00480 1 IGIDIGGTKIAAALFDEEGEILARERVptPTTTTEETLVDAIAFFvdsaqRKFgELIAVGIGSPGLISPK-----YGYIT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 75 ATPKAGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLS--HPEMG 152
Cdd:pfam00480 76 NTPNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNgvAGEIG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 153 HIYIrrhPDDVYRGKCPYHGdCFEGLASGPAIEARWGKKAADLS-------------DLTQVWELEGYYIAQALAQYILI 219
Cdd:pfam00480 156 HIQL---DPNGPKCGCGNHG-CLETIASGRALEKRYQQKGEDLEgkdiivlaeqgdeVAEEAVERLARYLAKAIANLINL 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 671705950 220 LAPKKIILGGGVMQQKQVFPYIYQYVPKIMNSYFnfselsENISDYIVPPHLGSNAGIIGTLVLAQQ 286
Cdd:pfam00480 232 FDPQAIVLGGGVSNADGLLEAIRSLVKKYLNGYL------PVPPVIIVAASLGDNAGALGAAALAKQ 292
|
|
| NagC |
COG1940 |
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
1-286 |
1.34e-74 |
|
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];
Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 230.94 E-value: 1.34e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 1 MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKM---PDETIEKVIQYFRQF---------SLQAIGIGSFGPVDNDKtsq 68
Cdd:COG1940 6 YVIGIDIGGTKIKAALVDLDGEVLARERIPTPAgagPEAVLEAIAELIEELlaeagisrgRILGIGIGVPGPVDPET--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 69 tyGTITATPK-AGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLS 147
Cdd:COG1940 83 --GVVLNAPNlPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 148 --HPEMGHIYIRRHPDDVYRGKcpyHGdCFEGLASGPAIEARWGK-------KAADLSDL--------TQVWELEGYYIA 210
Cdd:COG1940 161 gnAGEIGHMPVDPDGPLCGCGN---RG-CLETYASGPALLRRARElggaeklTAEELFAAaragdplaLEVLDEAARYLG 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 671705950 211 QALAQYILILAPKKIILGGGVMQQkqvFPYIYQYVPKIMNSYfNFSELSENISdyIVPPHLGSNAGIIGTLVLAQQ 286
Cdd:COG1940 237 IGLANLINLLDPEVIVLGGGVSAA---GDLLLEPIREALAKY-ALPPAREDPR--IVPASLGDDAGLLGAAALALE 306
|
|
| ASKHA_ATPase_ROK |
cd23763 |
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ... |
4-283 |
3.44e-50 |
|
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.
Pssm-ID: 466849 [Multi-domain] Cd Length: 239 Bit Score: 166.10 E-value: 3.44e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGTKFVCAVGREDGTIIDRIEFPT---KMPDETIEKVIQYFRQF--------SLQAIGIGSFGPVDNDKtsqtyGT 72
Cdd:cd23763 2 GIDIGGTKIRAALVDLDGEILARERVPTpaeEGPEAVLDRIAELIEELlaeagvreRILGIGIGVPGPVDPET-----GI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 73 ITATPK-AGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLS--HP 149
Cdd:cd23763 77 VLFAPNlPWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANgaAG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 150 EMGHIyirrhpddvyrgkcpyhgdcfeglasgpaiearwgkkaadlsdltQVWELEGYYIAQALAQYILILAPKKIILGG 229
Cdd:cd23763 157 EIGHI---------------------------------------------TVLEEAARYLGIGLANLINLLNPELIVLGG 191
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 671705950 230 GVMQQkqvFPYIYQYVPKIMNSYFnFSELSENISdyIVPPHLGSNAGIIGTLVL 283
Cdd:cd23763 192 GVAEA---GDLLLEPIREAVRRRA-LPPLRRRVR--IVPSELGDDAGLLGAAAL 239
|
|
| ASKHA_NBD_ROK_FnNanK-like |
cd24068 |
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ... |
4-283 |
7.59e-43 |
|
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466918 [Multi-domain] Cd Length: 294 Bit Score: 148.47 E-value: 7.59e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGTKFVCAVGREDGTIIDRIEFPT---KMPDETIEKVIQYFRQFS----LQAIGIGSFGPVDNDKTSQTYGTitAT 76
Cdd:cd24068 4 GIDIGGTKIKYGLVDADGEILEKDSVPTpasKGGDAILERLLEIIAELKekydIEGIGISSAGQVDPKTGEVIYAT--DN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 77 PKaGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHP--EMGHI 154
Cdd:cd24068 82 LP-GWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSagELGHM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 155 YIrrhPDDVYRGKCPYHGdCFEGLASGPAI----EARWGKKAADLSDLTQVWElEG------------YYIAQALAQYIL 218
Cdd:cd24068 161 VV---DPGGRPCCCGGKG-CLEQYASGTALvrrvAEALGEPGIDGREIFDLAD-AGdplakevveefaEDLATGLANLVH 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 671705950 219 ILAPKKIILGGGVMQQKQVFpyiyqyVPKIMNSYFNFSELSENISDYIVPPHLGSNAGIIGTLVL 283
Cdd:cd24068 236 IFDPEVIVIGGGISAQGELF------LEELREELRKLLMPPLLDATKIEPAKLGNDAGLLGAAYL 294
|
|
| ASKHA_NBD_ROK_TtHK-like |
cd24065 |
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ... |
4-279 |
1.38e-36 |
|
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466915 [Multi-domain] Cd Length: 289 Bit Score: 132.07 E-value: 1.38e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGTKFVCAVGReDGTIIDRIEFPTkmPDETIEKVIQYFRQFSLQ---------AIGIGSFGPVDNDKtsqtyGTIT 74
Cdd:cd24065 4 GLDLGGTKIAAGVVD-GGRILSRLVVPT--PREGGEAVLDALARAVEAlqaeapgveAVGLGVPGPLDFRR-----GRVR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 75 ATPK-AGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGlSH---PE 150
Cdd:cd24065 76 FAPNiPGLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRG-RHgqaGE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 151 MGHIYIRRH-PDDvyrgKCPYHGdCFEGLASGPAI--EARWG-KKAADLSDLTQVWElEG------------YYIAQALA 214
Cdd:cd24065 155 IGHTTVLPGgPMC----GCGLVG-CLEALASGRALarDASFAyGRPMSTAELFELAQ-QGepkalriveqaaAHLGIGLA 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 671705950 215 QYILILAPKKIILGGGVMqqkQVFPYIYQyvpKIMNSYFNFSELSENISdyIVPPHLGSNAGIIG 279
Cdd:cd24065 229 NLQKALDPEVFVLGGGVA---QVGDYYLL---PVQEAARRYTEGWHAPP--LRLAHLGTDAGVIG 285
|
|
| ASKHA_NBD_ROK_ApGLK-like |
cd24063 |
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ... |
4-283 |
1.78e-36 |
|
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466913 [Multi-domain] Cd Length: 308 Bit Score: 132.46 E-value: 1.78e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGTKFVCAVGREDGTIIDRIEFPT---KMPDETIEKVIQYFRQF-------SLQAIGIGSFGPVDNDKtsqtyGTI 73
Cdd:cd24063 4 AVDIGGTWIRAGLVDEDGRILLKIRQPTpktGDPGTVSEQVLGLIETLlskagkdSIEGIGVSSAGPLDLRK-----GTI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 74 TATPKAGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLL---QGLSHpE 150
Cdd:cd24063 79 VNSPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLlgkNGNAA-E 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 151 MGHIYIRrhPDDVYRGKCPYHGdCFEGLASGPAIE--ARWGKKAADLSDLTQVWELEGYYI------------------- 209
Cdd:cd24063 158 VGHLVVD--TESGLKCGCGGYG-HWEAFASGRGIPrfAREWAEGFSSRTSLKLRNPGGEGItakevfsaarkgdplalki 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 210 --------AQALAQYILILAPKKIILGGGVMQQKQVFpyiyqYVPKIMN--SYFNFSELSEnisdyIVPPHLGSNAGIIG 279
Cdd:cd24063 235 ieklarynGRGIANVINAYDPELIVIGGSVFNNNKDI-----LDPLIEYleKNPAISKGPE-----IVLSELGDDVGLIG 304
|
....
gi 671705950 280 TLVL 283
Cdd:cd24063 305 ALAL 308
|
|
| ASKHA_NBD_ROK_SgGLK-like |
cd24061 |
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ... |
4-284 |
5.24e-34 |
|
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466911 [Multi-domain] Cd Length: 306 Bit Score: 125.93 E-value: 5.24e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGTKFVCAVGREDGTIIDRIEFPT-KMPDETIEKVIQ----YFRQFSLQAIGIGSFGPVDNDKtsqtyGTITATPK 78
Cdd:cd24061 3 GVDIGGTKIAAGVVDEEGEILATERVPTpPTADGIVDAIVEaveeLREGHDVSAVGVAAAGFVDADR-----ATVLFAPN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 79 AGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGL--SHPEMGHiyI 156
Cdd:cd24061 78 IAWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAfgIAGEFGH--I 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 157 RRHPDDVYRGkCPYHGdCFEGLASGPAIEaRWGKKAAD--------LSDLTQVWELEGYYI------------------A 210
Cdd:cd24061 156 RVVPDGLLCG-CGSRG-CWEQYASGRALV-RYAKEAANatpegaavLLADGSVDGITGKHIseaaragdpvaldalrelA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 211 QALAQYILILA----PKKIILGGGVMQQKQVFpyiyqyVPKIMNSYfnfsELSENISDY-----IVPPHLGSNAGIIGTL 281
Cdd:cd24061 233 RWLGAGLASLAalldPELFVIGGGVSDAGDLL------LDPIREAF----ERWLPGRGWrpiprLRTAQLGNDAGLIGAA 302
|
...
gi 671705950 282 VLA 284
Cdd:cd24061 303 DLA 305
|
|
| ASKHA_NBD_ROK_TM1224-like |
cd24059 |
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ... |
14-284 |
2.18e-33 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466909 [Multi-domain] Cd Length: 305 Bit Score: 124.24 E-value: 2.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 14 CAVGRED--GTIIDRIEFPTKM---PDETIEKVI--------QYFRQFSLQAIGIGSFGPVDNDKtsqtyGTITATPKA- 79
Cdd:cd24059 13 LSAVLCDlsGNILAREKYPLDEkenPEEVLEKLYelidrlleKENIKSKILGIGIGAPGPLDVEK-----GIILNPPNFp 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 80 GWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLS--HPEMGHIYIr 157
Cdd:cd24059 88 GWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDgyAGEIGHTSI- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 158 rhpddVYRGK---CPYHGdCFEGLASGPAIEARwgKKAADLSDLT-----------------QVWELEGYYIAQALAQYI 217
Cdd:cd24059 167 -----DINGPrcsCGNRG-CLELYASIPAIEKK--ARSALGSGRSfqldivealqkgdpiadEVIEEAAKYLGIGLVNLI 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 671705950 218 LILAPKKIILGGGVMQQKQVFpyiYQYVPKIMNSYFnFSELSENISdyIVPPHLGSNAGIIGTLVLA 284
Cdd:cd24059 239 NLLNPEAIIIGGELIYLGERY---LEPIEKEVNSRL-FGRNAREVR--ILKSSLGEDAPLLGAAALV 299
|
|
| ASKHA_NBD_ROK_BsGLK-like |
cd24062 |
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ... |
4-279 |
1.54e-31 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466912 [Multi-domain] Cd Length: 311 Bit Score: 119.32 E-value: 1.54e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGTKFVCAVGREDGTIIDRIEFPT--------------KMPDETIEKVIQYFRQFslQAIGIGSFGPVDNDKtsqt 69
Cdd:cd24062 4 GIDVGGTTIKMAFLTQEGEIVQKWEIPTnkleggeniitdiaESIQQLLEELGYSKEDL--IGIGVGVPGPVDVET---- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 70 yGTITATPKAGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHP 149
Cdd:cd24062 78 -GTVEVAVNLGWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 150 --EMGHIYIRrhPDDVYRGKCPYHGdCFEGLASGPAI--------EARWGKKAADLSDLTQ------VWELE-------- 205
Cdd:cd24062 157 agEIGHITVN--PEGGAPCNCGKTG-CLETVASATGIvriareelEEGKGSSALRILALGGeltakdVFEAAkagdelal 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 206 ------GYYIAQALAQYILILAPKKIILGGGVMQQKQ-VFPYIYQYVPKimnsyFNFSELSENISdyIVPPHLGSNAGII 278
Cdd:cd24062 234 avvdtvARYLGLALANLANTLNPEKIVIGGGVSAAGEfLLSPVKEYFDR-----FTFPRVRQDTE--IVLATLGNDAGVI 306
|
.
gi 671705950 279 G 279
Cdd:cd24062 307 G 307
|
|
| ROK_glcA_fam |
TIGR00744 |
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ... |
4-284 |
3.42e-31 |
|
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]
Pssm-ID: 273246 [Multi-domain] Cd Length: 318 Bit Score: 118.46 E-value: 3.42e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDET----IEKVIQYFRQF------SLQAIGIGSFGPVDNDKtsqtyGTI 73
Cdd:TIGR00744 2 GVDIGGTTIKLGVVDEEGNILSKWKVPTDTTPETivdaIASAVDSFIQHiakvghEIVAIGIGAPGPVNRQR-----GTV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 74 TATPKAGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGL--SHPEM 151
Cdd:TIGR00744 77 YFAVNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHngVGAEI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 152 GHiyIRRHPDDVYRGKCPYHGdCFEGLASGPAI---EARWGKKAADLSDLTQVWELEGY--------------------- 207
Cdd:TIGR00744 157 GH--IRMVPDGRLLCNCGKQG-CIETYASATGLvryAKRANAKPERAEVLLALGDGDGIsakhvfvaarqgdpvavdsyr 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 208 YIAQALAQYILILA----PKKIILGGGVMQQKQVFpyiyqyVPKIMNSYFNFSELSENISDYIVPPHLGSNAGIIGTLVL 283
Cdd:TIGR00744 234 EVARWAGAGLADLAslfnPSAIVLGGGLSDAGDLL------LDPIRKSYKRWLFGGARQVADIIAAQLGNDAGLVGAADL 307
|
.
gi 671705950 284 A 284
Cdd:TIGR00744 308 A 308
|
|
| ASKHA_ATPase_ROK_Lmo0178-like |
cd24071 |
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ... |
20-288 |
6.46e-31 |
|
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466921 [Multi-domain] Cd Length: 312 Bit Score: 117.77 E-value: 6.46e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 20 DGTIIDRIEFPTKM---PDETIEKVIQYFRQFSLQA--------IGIGSFGPVDNDKtsqtyGTITATPKAGWRHYPFLQ 88
Cdd:cd24071 21 KGKILEKTRIPFDHetdPEKVIELIAENIKKLIKNKhvekkllgIGIAVSGLVDSKK-----GIVIRSTILGWENVELKK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 89 TVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGL--SHPEMGHIYIrrHPDDvYRG 166
Cdd:cd24071 96 ILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNfgGAGEIGHMTI--QPDG-RKC 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 167 KCPYHGdCFEGLASGPAIEARwGKKAADLSDLTQVWELE-------------------------GYYIAQALAQYILILA 221
Cdd:cd24071 173 YCGQKG-CLEAYASFEALVNE-IKELTESYPLSLLKELEdfeiekvreaaeegdsvatelfkkaGEYLGIGIKNLINIFN 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 671705950 222 PKKIILGGGVMQQKQVF-PYIYQYVPKimNSyfnFSELSENISdyIVPPHLGSNAGIIGTLVLAQQAL 288
Cdd:cd24071 251 PEAIIIGGEGLEFKDYFlPKIIEIAKE--NF---FGKAGRNVI--ILVDSLGEDAWVLGAALLVIDHL 311
|
|
| ASKHA_NBD_ROK_TmGLK-like |
cd24064 |
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ... |
4-279 |
1.28e-29 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466914 [Multi-domain] Cd Length: 301 Bit Score: 114.13 E-value: 1.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGTKFVCAVGREDGTIIDRIEFPTKMpDETIEKVIQYFRQ--------FSLQAIGIGSFGPVDNDKtsqtyGTITA 75
Cdd:cd24064 3 GIDLGGTDTKIGIVDENGDILKKKTIDTKV-ENGKEDVINRIAEtvnelieeMELLGIGIGSPGSIDREN-----GIVRF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 76 TPK-AGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLS--HPEMG 152
Cdd:cd24064 77 SPNfPDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDgiAAELG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 153 HIYIrrHPDDvYRGKCPYHGdCFEGLASGPAI--EARWGKK--------------------AADLSDL--TQVWELEGYY 208
Cdd:cd24064 157 HVIV--EPNG-PICGCGNRG-CVEAFASATAIirYARESRKrypdslagesekinakhvfdAARKNDPlaTMVFRRVVDA 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 671705950 209 IAQALAQYILILAPKKIILGGGVMQQKQVF--PYIYQYVPKIMNSYFNFSElsenisdyIVPPHLGSNAGIIG 279
Cdd:cd24064 233 LAIAIGGFVHIFNPEIIIIGGGISRAGSFLldPIREKTKKYVMLSFQDTYS--------IELSNLVEDAGILG 297
|
|
| ASKHA_ATPase_ROK_BsXylR-like |
cd24076 |
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ... |
20-285 |
3.89e-29 |
|
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.
Pssm-ID: 466926 [Multi-domain] Cd Length: 303 Bit Score: 112.66 E-value: 3.89e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 20 DGTIIDRIEFPTKM---PDETIEKVIQYFRQF---------SLQAIGIGSFGPVDNDKtsqtyGTITATPKAGWRHYPFL 87
Cdd:cd24076 21 AGEVLWRREVPLPAsddPDEVLAQLAALIREAlaaapdsplGILGIGVGVPGLVDSED-----GVVLLAPNLGWRDVPLR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 88 QTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLS--HPEMGHIYIRRHpddvyr 165
Cdd:cd24076 96 DLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASgfAGEIGHMTVDPD------ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 166 GK---CPYHGdCFEGLASGPAIEARWGKK-----AADLSDLTQVWELE-----------GYYIAQALAQYILILAPKKII 226
Cdd:cd24076 170 GPpcsCGNRG-CWETYASERALLRAAGRLgaggePLSLAELVEAARAGdpaalaaleevGEYLGIGLANLVNTFNPELVV 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 671705950 227 LGGGVMqqkQVFPYIYQYVPKIMNSYfNFSELSENISdyIVPPHLGSNAGIIG--TLVLAQ 285
Cdd:cd24076 249 LGGALA---PLGPWLLPPLRAEVARR-ALPAPARDVR--IVVSRLGEDAAALGaaALAIDH 303
|
|
| ASKHA_ATPase_ROK_CYANR |
cd24073 |
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ... |
20-238 |
1.06e-24 |
|
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466923 [Multi-domain] Cd Length: 304 Bit Score: 100.70 E-value: 1.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 20 DGTII--DRIEFPTKMPD---ETIEKVIQYFRQFS------LQAIGIGSFGPVDndktSQTyGTITATPKAGWRHYPFLQ 88
Cdd:cd24073 21 RGNVLasHTLPLDSGDPEavaEAIAEAVAELLAQAglspdrLLGIGVGLPGLVD----AET-GICRWSPLLGWRDVPLAE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 89 TVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGlSH---PEMGHIYIRrhPDdvyr 165
Cdd:cd24073 96 LLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRG-AHggaGEIGHTTVD--PD---- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 166 GK---CPYHGdCFEGLASGPAIEARWGKKAADLSDLT----------------QVWELEGYYIAQALAQYILILAPKKII 226
Cdd:cd24073 169 GPpcrCGKRG-CLEAYASDPAILRQAREAGLRGEPLTiedllaaaragdpaarAILRRAGRALGLALANLVNLLDPELII 247
|
250
....*....|..
gi 671705950 227 LGGGVMQQKQVF 238
Cdd:cd24073 248 ISGEGVRAGDLL 259
|
|
| ASKHA_NBD_ROK-like |
cd24152 |
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ... |
8-283 |
1.49e-24 |
|
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466988 [Multi-domain] Cd Length: 286 Bit Score: 99.95 E-value: 1.49e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 8 GGTKFVCAVGREDGTIIDRIEFPTKMPD-----ETIEKVIQYFRQfSLQAIGIGSFGPVDnDKTSQTYGtITATPKAgwR 82
Cdd:cd24152 8 GGTFIKYALVDENGNIIKKGKIPTPKDSleeflDYIKKIIKRYDE-EIDGIAISAPGVID-PETGIIYG-GGALPYL--K 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 83 HYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQG--LSHPEMGHIYIrrHP 160
Cdd:cd24152 83 GFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGshFFAGEFSYLLT--DD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 161 DDVYrgkcpyhGDCFEGLASGPAIEARWGKKAAD-LSDLTQVWEL--EG------------YYIAQALAQYILILAPKKI 225
Cdd:cd24152 161 DDKD-------LLFFSGLASMFGLVKRYNKAKGLePLDGEEIFEKyaKGdeaakkildeyiRNLAKLIYNIQYILDPEVI 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 671705950 226 ILGGGVMQQkqvfPYIYQYVPKIMNSYFnfselsENISDYIVPP-----HLGSNAGIIGTLVL 283
Cdd:cd24152 234 VIGGGISEQ----PLFIEDLKKEVNEIL------ANRPGSIPKPeikacKFGNDANLLGALYN 286
|
|
| ASKHA_ATPase_ROK_Mlc |
cd24074 |
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ... |
25-288 |
2.57e-23 |
|
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466924 [Multi-domain] Cd Length: 322 Bit Score: 97.38 E-value: 2.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 25 DRIEFPTKMPDE----TIEKVIQYFRQFS-----LQAIGIGSFGPVDndkTSQtyGTITATPKAGWRHYPFLQTVKNEMK 95
Cdd:cd24074 29 ERYPLPAKDNDPfldrLLESISEFFSRHQkklerLTAIAITLPGIID---PES--GIVHRLPFYDIKNLPLGEALEQHTG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 96 IPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQ-GLSHP-EMGHIYIRRHPDDVYrgkCPYHGd 173
Cdd:cd24074 104 LPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHaGSSRLgELGHTQIDPYGKRCY---CGNHG- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 174 CFEGLASGPAIEARWGKKAADLSD-LTQVWELE----------------------GYYIAQALAQYILILAPKKIILGGG 230
Cdd:cd24074 180 CLETVASIPAILEQANQLLEQSPDsMLHGQPISieslcqaalagdplaqdiiiqvGRHLGRILAILVNLFNPEKILIGSP 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 671705950 231 VMQQK-QVFPYIYQY-----VPkimnsyfnfsELSENISdyIVPPHLgSNAGIIGTLVLAQQAL 288
Cdd:cd24074 260 LNNAAeILFPALSQSirqqsLP----------AYSQHLQ--IESTKF-YNDGTMPGAALIKDAL 310
|
|
| ASKHA_NBD_ROK_AlsK |
cd24070 |
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ... |
4-284 |
4.95e-23 |
|
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466920 [Multi-domain] Cd Length: 293 Bit Score: 96.08 E-value: 4.95e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGTKFVCAVGREDGTIIDRIEFPTKMP---DETIEKVIQYFRQF------SLQAIGIGSFGPVDNDKTsqtygTIT 74
Cdd:cd24070 5 GIDIGGTNIRIGLVDEDGKLLDFEKVPSKDLlraGDPVEVLADLIREYieeaglKPAAIVIGVPGTVDKDRR-----TVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 75 ATPK-AGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGlSH---PE 150
Cdd:cd24070 80 STPNiPGLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDDEGVVLGFYIGTGIGNAILINGKPLRG-KNgvaGE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 151 MGHIYIRRHpddvyRGKCPYHG-DCFEGLASGPAIEA------------RWGKKAADLSDLTQVWELEGYYIAQAlaqyI 217
Cdd:cd24070 159 LGHIPVYGN-----GKPCGCGNtGCLETYASGRALEEiaeehypdtpilDIFVDHGDEPELDEFVEDLALAIATE----I 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 671705950 218 LILAPKKIILGGGVMQQKQvFP------YIYQYVPKimnsyfnfSELSENISdyIVPPHLGSNAGIIGTLVLA 284
Cdd:cd24070 230 NILDPDAVILGGGVIDMKG-FPretleeYIRKHLRK--------PYPADNLK--IIYAELGPEAGVIGAAIYA 291
|
|
| ASKHA_NBD_ROK_EcNanK-like |
cd24069 |
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ... |
5-283 |
2.35e-22 |
|
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466919 [Multi-domain] Cd Length: 283 Bit Score: 93.89 E-value: 2.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 5 IEAGGTKfVCAVGREDGTIIDRIEFPTKMPD--ETIEKVIQ-----YFRQFslQAIGIGSFGPVDNdktsqtyGTITAT- 76
Cdd:cd24069 3 IDIGGTK-IAAALIGNGQIIDRRQIPTPRSGtpEALADALAslladYQGQF--DRVAVASTGIIRD-------GVLTALn 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 77 PK--AGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGL----SHpe 150
Cdd:cd24069 73 PKnlGGLSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPnglaGH-- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 151 MGHIYIRrhPDDVyRGKCPYHGdCFEGLASGPAIEA---RWGKKAADLSDL-----------TQVWELEGYYIAQALAQY 216
Cdd:cd24069 151 IGHTLAD--PPGP-VCGCGRRG-CVEAIASGTAIAAaasEILGEPVDAKDVferarsgdeeaARLIDRAARALADLIADL 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 671705950 217 ILILAPKKIILGGGV----------MQQKQVFPYIYQYVpkimnsyfnfselsenisdyIVPPHLGSNAGIIGTLVL 283
Cdd:cd24069 227 KATLDLDCVVIGGSVglaegflervEQYLADEPAIFRVS--------------------LEPARLGQDAGLLGAALL 283
|
|
| ASKHA_ATPase_ROK_NagC |
cd24075 |
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ... |
36-241 |
8.74e-20 |
|
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466925 [Multi-domain] Cd Length: 315 Bit Score: 87.42 E-value: 8.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 36 ETIEKVIQYFRQFS-----LQAIGIGSFGPVDNDKtsqtyGTITATPKAGWRHYPFLQTVKNEMKIPVGFSTDVNAAALG 110
Cdd:cd24075 43 QLIEEIAQFLKSHRrktqrLIAISITLPGLINPKT-----GVVHYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 111 EFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLL--QGLSHPEMGHIYI-----RRHpddvyrgkCPYHGdCFEGLASGPA 183
Cdd:cd24075 118 EHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFlgQNGNAGEIGHIQIeplgeRCH--------CGNFG-CLETVASNAA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 184 IEARWGK---------------------KAADLSD--LTQVWELEGYYIAQALAQYILILAPKKIILGGGVMQ-QKQVFP 239
Cdd:cd24075 189 IEQRVKKllkqgyasqltlqdctikdicQAALNGDqlAQDVIKRAGRYLGKVIAILINLLNPQKIIIAGEITQaDKVLLP 268
|
..
gi 671705950 240 YI 241
Cdd:cd24075 269 VI 270
|
|
| ASKHA_NBD_ROK_NAGK |
cd24057 |
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ... |
1-279 |
3.24e-17 |
|
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466907 [Multi-domain] Cd Length: 298 Bit Score: 79.97 E-value: 3.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 1 MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPD-----ETI-EKVIQYFRQFSLQA-IGIGSFGPVDNDKtsqtyGTI 73
Cdd:cd24057 1 MYYGFDIGGTKIEFAVFDEALQLVWTKRVPTPTDDyaaflAAIaELVAEADARFGVKGpVGIGIPGVIDPED-----GTL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 74 TATPKAGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSH--PEM 151
Cdd:cd24057 76 ITANIPAAKGRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLILGTGVGGGLVVNGRLVGGRSGiaGEW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 152 GH----IYIRRHPDD--VYRGKCPYHGdCFEGLASGP-----------------AIEARWgkkAADLSDLTQVWELEGYY 208
Cdd:cd24057 156 GHgplpADALLLGYDlpVLRCGCGQTG-CLETYLSGRglerlyahlygeeldapEIIAAW---AAGDPQAVAHVDRWLDL 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 671705950 209 IAQALAQYILILAPKKIILGGGVMQqkqvFPYIYQYVPKIMNSYFnfseLSENISDYIVPPHLGSNAGIIG 279
Cdd:cd24057 232 LAGCLANILTALDPDVVVLGGGLSN----FPALIAELPAALPAHL----LSGARTPRIVPARHGDAGGVRG 294
|
|
| ASKHA_NBD_ROK_EcFRK-like |
cd24066 |
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ... |
4-279 |
3.99e-17 |
|
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466916 [Multi-domain] Cd Length: 294 Bit Score: 79.56 E-value: 3.99e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGTKFVCAVGREDGTIIDRIEFPTKMPD-----ETIEKVIQYFRQFSLQA--IGIGSFGPVDndktsqtygtitat 76
Cdd:cd24066 3 GIDLGGTKIEGIALDRAGRELLRRRVPTPRGDyeatlDAIADLVEEAEEELGAPatVGIGTPGSIS-------------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 77 PKAG--------W--RHyPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGL 146
Cdd:cd24066 69 PRTGlvknanstWlnGK-PLKADLEARLGRPVRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 147 SH--PEMGHIYIRRHPDDVYRGK---CPYHGdCFEGLASGPAIEARW----GKK--------AADLSDLTQVWELEGY-- 207
Cdd:cd24066 148 NGiaGEWGHNPLPWPDEDELPGPpcyCGKRG-CVETFLSGPALERDYarltGKTlsaeeivaLARAGDAAAVATLDRFld 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 671705950 208 YIAQALAQYILILAPKKIILGGGVMQqkqvFPYIYQYVPKIMNSYFnFSELSENisdYIVPPHLGSNAGIIG 279
Cdd:cd24066 227 RLGRALANVINILDPDVIVLGGGLSN----IDELYTEGPAALARYV-FSDEVET---PIVKNKHGDSSGVRG 290
|
|
| PRK05082 |
PRK05082 |
N-acetylmannosamine kinase; Provisional |
5-289 |
8.35e-17 |
|
N-acetylmannosamine kinase; Provisional
Pssm-ID: 235338 [Multi-domain] Cd Length: 291 Bit Score: 78.80 E-value: 8.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 5 IEAGGTKFVCAVGREDGTIIDRIEFPT-------KMPDETIEKVIQYFRQFslQAIGIGSFGPVDNdktsqtyGTITA-T 76
Cdd:PRK05082 6 IDIGGTKIAAALVGEDGQIRQRRQIPTpasqtpeALRQALSALVSPLQAQA--DRVAVASTGIIND-------GILTAlN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 77 PK--AGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDsCLYITIGTGIGAGAIVEGRLLQGlSHPEMGHI 154
Cdd:PRK05082 77 PHnlGGLLHFPLVQTLEQLTDLPTIALNDAQAAAWAEYQALPDDIRN-MVFITVSTGVGGGIVLNGKLLTG-PGGLAGHI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 155 -YIRRHPDDVYRGkCPYHGdCFEGLASGPAIEARwGKKAADLSDLTQVWEL--EGYYIAQAL----AQYI--LILAPK-- 223
Cdd:PRK05082 155 gHTLADPHGPVCG-CGRRG-CVEAIASGRAIAAA-AQGWLAGCDAKTIFERagQGDEQAQALinrsAQAIarLIADLKat 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 224 ----KIILGGGV------MQQKQVF----PYIYQyVPkimnsyfnfselsenisdyIVPPHLGSNAGIIGTLVLAQQALQ 289
Cdd:PRK05082 232 ldcqCVVLGGSVglaegyLELVQAYlaqePAIYH-VP-------------------LLAAHYRHDAGLLGAALWAQGEKL 291
|
|
| PRK09698 |
PRK09698 |
D-allose kinase; Provisional |
4-292 |
3.24e-14 |
|
D-allose kinase; Provisional
Pssm-ID: 182034 [Multi-domain] Cd Length: 302 Bit Score: 71.55 E-value: 3.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGTKFVCAVGREDGTIIDRIEFPTK--MPDETIEKVIQYFRQF------SLQAIGIGSFGPVDNDKTsqtygTITA 75
Cdd:PRK09698 8 GIDMGGTHIRFCLVDAEGEILHCEKKRTAevIAPDLVSGLGEMIDEYlrrfnaRCHGIVMGFPALVSKDRR-----TVIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 76 TP---KAGWRHYPFLQTVKNEMKIPVGFSTDVNAaalgeFLFGEAKGL----DSCLYITIGTGIGAGAIVEGRLLQGLsH 148
Cdd:PRK09698 83 TPnlpLTALDLYDLADKLENTLNCPVFFSRDVNL-----QLLWDVKENnltqQLVLGAYLGTGMGFAVWMNGAPWTGA-H 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 149 ---PEMGHIYIrrhPDDVYRGKCPYHGdCFEGLASGPAIEARWGKKAAD--LSDLTQVW----ELEGYYI--AQALAQYI 217
Cdd:PRK09698 157 gvaGELGHIPL---GDMTQHCGCGNPG-CLETNCSGMALRRWYEQQPRDypLSDLFVHAgdhpFIQSLLEnlARAIATSI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 218 LILAPKKIILGGGVMQQKQvFPY------IYQYVPKIMnSYFNFSelsenisdyIVPPHLGSNAGIIGTLVLAQQALQVE 291
Cdd:PRK09698 233 NLFDPDAIILGGGVMDMPA-FPRetliamIQKYLRKPL-PYEVVR---------FIYASSSDFNGAQGAAILAHQRFLPQ 301
|
.
gi 671705950 292 S 292
Cdd:PRK09698 302 S 302
|
|
| ASKHA_ATPase_ROK_SaXylR-like |
cd24077 |
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ... |
20-288 |
1.15e-13 |
|
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466927 [Multi-domain] Cd Length: 295 Bit Score: 69.88 E-value: 1.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 20 DGTIIDR--IEFPTKMPDETIEKVIQYFRQFSLQA---------IGIGSFGPVDNDktsqtygTITATPKAGWRHYPFLQ 88
Cdd:cd24077 21 DGEIISSkqIKLLDISFENILEILKSIIQELISQApktpyglvgIGIGIHGIVDEN-------EIIFTPYYDLEDIDLKE 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 89 TVKNEMKIPVGFSTDVNAAALGEFLFGEakGLDSCLYITIGTGIGAGAIVEGRL---LQGLSHpEMGHIYIrrhpddVYR 165
Cdd:cd24077 94 KLEEKFNVPVYLENEANLSALAERTFSE--DYDNLISISIHSGIGAGIIINNQLyrgYNGFAG-EIGHMII------VPN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 166 GK-CP--YHGdCFEGLASGPAIE----ARWGKKAADLSDLTQvWELEG------------YYIAQALAQYILILAPKKII 226
Cdd:cd24077 165 GKpCPcgNKG-CLEQYASEKALLkelsEKKGLETLTFDDLIQ-LYNEGdpealelidqfiKYLAIGINNIINTFNPEIII 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 671705950 227 LGGgvmqqkQVFPYIYQYVPKIMNSYFNFselsenISDY--IVPPHLGSNAGIIG-TLVLAQQAL 288
Cdd:cd24077 243 INS------SLINEIPELLEKIKEQLSSS------FNKYveILISTLGKNATLLGgAAVAIKNFL 295
|
|
| ASKHA_NBD_ROK_GNE |
cd24060 |
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ... |
8-201 |
1.36e-13 |
|
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.
Pssm-ID: 466910 [Multi-domain] Cd Length: 305 Bit Score: 69.75 E-value: 1.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 8 GGTKFVCAVGREDGTII------------DRIEFPTKMPDETIEKVIQyfRQFSLQAIGIGSFGPVDNDKtsqtyGTITA 75
Cdd:cd24060 8 GGTNLRVAIVSMKGEIVkkytqpnpktyeERIDLILQMCVEAASEAVK--LNCRILGVGISTGGRVNPRE-----GIVLH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 76 TPK--AGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSH--PEM 151
Cdd:cd24060 81 STKliQEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGGIILNHELIHGSSFcaAEL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 671705950 152 GHIYIRrhpddvYRG---KCPYHGdCFEGLASGPAIeARWGKKAADlSDLTQV 201
Cdd:cd24060 161 GHIVVS------LDGpdcMCGSHG-CVEAYASGMAL-QREAKKLHD-EDLLLV 204
|
|
| ASKHA_NBD_ROK_PPGK |
cd24058 |
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ... |
4-284 |
4.43e-13 |
|
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466908 [Multi-domain] Cd Length: 239 Bit Score: 67.21 E-value: 4.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 4 GIEAGGT--KfVCAVGREDGTII-DRIEFPTKMPD------ETIEKVIQYFRQFSlqAIGIGSFGPVDNDKTsqtygtIT 74
Cdd:cd24058 3 GIDIGGSgiK-GAIVDTDTGELLsERIRIPTPQPAtpeavaDVVAELVAHFPWFG--PVGVGFPGVVRRGVV------RT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 75 ATP-KAGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLD-SCLYITIGTGIGAGAIVEGRLLQGLshpEMG 152
Cdd:cd24058 74 AANlDKSWIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKgVVLVLTLGTGIGSALFVDGHLVPNT---ELG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 153 HIYIRrhpddvyrgkcpyhGDCFEGLASgpaiearwgKKAADLSDLTqvWELEGYYIAQALAQYILILAPKKIILGGGVM 232
Cdd:cd24058 151 HLEIR--------------GKDAEERAS---------LGVRAREDLG--WKRWAKRVNKYLQYLERLFNPDLFIIGGGNS 205
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 671705950 233 QqkqvfpYIYQYVPKIMNSYfnfselsenisdYIVPPHLGSNAGIIGTLVLA 284
Cdd:cd24058 206 K------KADKFLPLLDVKT------------PVVPAVLRNDAGIVGAALLA 239
|
|
| ASKHA_ATPase_ROK_YphH-like |
cd24072 |
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ... |
53-262 |
9.89e-13 |
|
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466922 [Multi-domain] Cd Length: 308 Bit Score: 67.44 E-value: 9.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 53 IGIGSFGPVDNDKtsqtyGTITATPKAGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGI 132
Cdd:cd24072 63 IALAIQGLVDSHK-----GVSLWSPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGI 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 133 GAGAIVEGRLLQGLSHP--EMGHIYIrrHPDDVyRGKCPYHGdCFEGLASGPAIEARWGK------KAADLSDL------ 198
Cdd:cd24072 138 GSAIVIDNKLYIGASSGsgEIGHTKV--NPDGA-RCDCGRRG-CLETVASNSALKRNARVtlklgpVSADPEKLtmeqli 213
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 671705950 199 ----------TQVWELEGYYIAQALAQYILILAPKKIILGGGVMqqkQVFPYIYQYVPKIMNSYFnFSELSENI 262
Cdd:cd24072 214 ealeegepiaTQIFDRAANAIGRSLANILNLLNPEQVLLYGRGC---RAGDLLLPAIRRAIAENP-FSQHATQI 283
|
|
| PRK13310 |
PRK13310 |
N-acetyl-D-glucosamine kinase; Provisional |
1-247 |
6.01e-08 |
|
N-acetyl-D-glucosamine kinase; Provisional
Pssm-ID: 183967 [Multi-domain] Cd Length: 303 Bit Score: 53.07 E-value: 6.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 1 MLGGIEAGGTKFVCAVGREDGTII--DRIEFPTKMPDE---TIEKVIQ-YFRQFSLQ-AIGIGSFGPVDNDKtsqtyGTI 73
Cdd:PRK13310 1 MYYGFDIGGTKIELGVFNEKLELQweERVPTPRDSYDAfldAVCELVAeADQRFGCKgSVGIGIPGMPETED-----GTL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 74 TATPKAGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSH--PEM 151
Cdd:PRK13310 76 YAANVPAASGKPLRADLSARLGRDVRLDNDANCFALSEAWDDEFTQYPLVMGLILGTGVGGGLVFNGKPISGRSYitGEF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 152 GHIyirRHPDD----------VYRGKCPYHGdCFEGLASGPAIEARW------GKKAADL------SDLTQVWELEGY-- 207
Cdd:PRK13310 156 GHM---RLPVDaltllgwdapLRRCGCGQKG-CIENYLSGRGFEWLYqhyygePLQAPEIialyyqGDEQAVAHVERYld 231
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 671705950 208 YIAQALAQYILILAPKKIILGGGVMQqkqvFPYIYQYVPK 247
Cdd:PRK13310 232 LLAICLGNILTIVDPHLVVLGGGLSN----FDAIYEQLPK 267
|
|
| PRK09557 |
PRK09557 |
fructokinase; Reviewed |
97-252 |
2.03e-06 |
|
fructokinase; Reviewed
Pssm-ID: 236565 [Multi-domain] Cd Length: 301 Bit Score: 48.48 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 97 PVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLS--HPEMGHIYIRRHPDDVYRGK------C 168
Cdd:PRK09557 99 EVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAINGRVHIGGNgiAGEWGHNPLPWMDEDELRYRnevpcyC 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705950 169 PYHgDCFEGLASGPAI----EARWGKKA--------ADLSDLTQVWELEGYY--IAQALAQYILILAPKKIILGGGVMQQ 234
Cdd:PRK09557 179 GKQ-GCIETFISGTGFatdyRRLSGKALkgseiirlVEEGDPVAELAFRRYEdrLAKSLAHVINILDPDVIVLGGGMSNV 257
|
170
....*....|....*...
gi 671705950 235 KQvfpyIYQYVPKIMNSY 252
Cdd:PRK09557 258 DR----LYPTLPALLKQY 271
|
|
| |
