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Conserved domains on  [gi|671705952|gb|KFF57868|]
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hypothetical protein CM50_16990 [Bacillus subtilis]

Protein Classification

HNH/ENDO VII family nuclease( domain architecture ID 10627612)

HNH/ENDO VII family nuclease with a conserved LHH motif

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LHH pfam14411
A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of ...
 154-235 2.44e-32

A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif, LHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. Like WHH and AHH, LHH nuclease contain 4 conserved histidines of which, the first one is predicted to bind metal-ion and other three ones are involved in activation of water molecule for hydrolysis.


:

Pssm-ID: 433940  Cd Length: 76  Bit Score: 112.83  E-value: 2.44e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705952  154 TNLQLMKLGNAPFAKDGTQINLHHLIQEEPGTMVEVPESLHKKYHNILHGLKENGQSFRNnpelsaQYDSFRKRYWKWRA 233
Cdd:pfam14411   1 TNLELMEKGNAPIDNDGKPINLHHIGQKEDGPLAELTKSEHKDNHKILHESFRPSQIDRK------EFEKFRRAYWKWRA 74


                  ..
gi 671705952  234 QQ 235
Cdd:pfam14411  75 ED 76
 
Name Accession Description Interval E-value
LHH pfam14411
A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of ...
 154-235 2.44e-32

A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif, LHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. Like WHH and AHH, LHH nuclease contain 4 conserved histidines of which, the first one is predicted to bind metal-ion and other three ones are involved in activation of water molecule for hydrolysis.


Pssm-ID: 433940  Cd Length: 76  Bit Score: 112.83  E-value: 2.44e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705952  154 TNLQLMKLGNAPFAKDGTQINLHHLIQEEPGTMVEVPESLHKKYHNILHGLKENGQSFRNnpelsaQYDSFRKRYWKWRA 233
Cdd:pfam14411   1 TNLELMEKGNAPIDNDGKPINLHHIGQKEDGPLAELTKSEHKDNHKILHESFRPSQIDRK------EFEKFRRAYWKWRA 74


                  ..
gi 671705952  234 QQ 235
Cdd:pfam14411  75 ED 76
 
Name Accession Description Interval E-value
LHH pfam14411
A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of ...
 154-235 2.44e-32

A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif, LHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. Like WHH and AHH, LHH nuclease contain 4 conserved histidines of which, the first one is predicted to bind metal-ion and other three ones are involved in activation of water molecule for hydrolysis.


Pssm-ID: 433940  Cd Length: 76  Bit Score: 112.83  E-value: 2.44e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671705952  154 TNLQLMKLGNAPFAKDGTQINLHHLIQEEPGTMVEVPESLHKKYHNILHGLKENGQSFRNnpelsaQYDSFRKRYWKWRA 233
Cdd:pfam14411   1 TNLELMEKGNAPIDNDGKPINLHHIGQKEDGPLAELTKSEHKDNHKILHESFRPSQIDRK------EFEKFRRAYWKWRA 74


                  ..
gi 671705952  234 QQ 235
Cdd:pfam14411  75 ED 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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